392,140 results match your criteria Insulin [Journal]


Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Cardiology Department, University Hospital Center Dijon Bourgogne, France.

Background: - In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD).

Objectives: - The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admitted for acute myocardial infarction (AMI).

Methods: - All patients with T2D admitted to our university hospital for AMI from March 2015 to February 2017 who received intravenous (IV) insulin therapy and underwent coronary angiography were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12623636193002
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http://dx.doi.org/10.1016/j.diabet.2019.01.012DOI Listing
February 2019
1 Read

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

The effects of roux en y gastric bypass surgery on neurobehavioral symptom domains associated with severe obesity.

Physiol Behav 2019 Feb 11. Epub 2019 Feb 11.

Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States. Electronic address:

Background: Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery.

Methods: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obese women (body mass index > 35 kg/m; N = 19). Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.013DOI Listing
February 2019

[The prospective of using plant polyphenols as functional food ingredients].

Vopr Pitan 2018 13;87(6):57-66. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10067DOI Listing
November 2018

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Mol Nutr Food Res 2019 Feb 14:e1800967. Epub 2019 Feb 14.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Introduction: Few data exist examining the effects of whole grain (WG) versus refined grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function.

Methods: In a double-blind crossover randomized controlled trial, 13 sedentary prediabetic adults (37.2±1. Read More

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http://dx.doi.org/10.1002/mnfr.201800967DOI Listing
February 2019

Molecular dynamic (MD) studies on Gln233Arg (rs1137101) polymorphism of leptin receptor gene and associated variations in the anthropometric and metabolic profiles of Saudi women.

PLoS One 2019 14;14(2):e0211381. Epub 2019 Feb 14.

Central Laboratory, Female Center for Scientific & Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

The Gln233Arg (A>G; rs1137101) polymorphism of the leptin receptor gene (LEPR) has been investigated extensively and is reported to be associated with different metabolic states. In this investigation, we aimed to study the frequency of Gln233Arg genotypes and alleles in a group of Saudi women stratified by their body mass index (BMI), to correlate the LEPR genotypes with variations in anthropometric, lipid and hormonal parameters and to investigate conformational and structural variations in the mutant LEPR using molecular dynamic (MD) investigations. The study group included 122 Saudi women (normal weight = 60; obese = 62) attending the clinics for a routine checkup. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211381PLOS
February 2019

Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

H Teede, Monash Centre for Health Research and Implementation, Monash University, Clayton, Australia.

Objective: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-050
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http://dx.doi.org/10.1530/EC-18-0502DOI Listing
February 2019
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Detection and Control of Unannounced Exercise in the Artificial Pancreas without Additional Physiological Signals.

IEEE J Biomed Health Inform 2019 Feb 11. Epub 2019 Feb 11.

The purpose of this study was to develop an algorithm that detects aerobic exercise and triggers disturbance rejection actions to prevent exercise-induced hypoglycemia. This approach can provide a solution to poor glycemic control during and after aerobic exercise, a major hindrance in the participation of exercise by patients with type 1 diabetes. This novel exercise-induced hypoglycemia reduction algorithm (EHRA) detects exercise using a threshold on a disturbance term, a parameter estimated from an augmented minimal model using an Unscented Kalman Filter. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2898558DOI Listing
February 2019

Inactivity Induces Resistance to the Metabolic Benefits Following Acute Exercise.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Kinesiology and Health Education, University of Texas at Austin, United States.

Acute exercise improves postprandial lipemia, glucose tolerance, and insulin sensitivity, all of which are risk factors for cardiovascular disease. However, recent research suggests that prolonged sedentary behavior might abolish these healthy metabolic benefits. Accordingly, this study aimed to elucidate the impact of an acute bout of exercise on postprandial plasma triglyceride, glucose, and insulin concentrations after four days of prolonged sitting (~13. Read More

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http://dx.doi.org/10.1152/japplphysiol.00968.2018DOI Listing
February 2019

Disuse-induced insulin resistance susceptibility coincides with a dysregulated skeletal muscle metabolic transcriptome.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Department of Physical Therapy, University of Utah, United States.

Short-term muscle disuse is characterized by skeletal muscle insulin resistance, though this response is divergent across subjects. The mechanisms regulating inactivity-induced insulin resistance between populations that are more or less susceptibile to disuse-induced insulin resistance are not known. RNA sequencing was conducted on vastus lateralis muscle biopsies from subjects before and after bed rest (n=26) to describe the transcriptome of inactivity-induced insulin resistance. Read More

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http://dx.doi.org/10.1152/japplphysiol.01093.2018DOI Listing
February 2019

DYSGLYCEMIA-BASED CHRONIC DISEASE: AN AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS POSITION STATEMENT.

Endocr Pract 2018 Nov;24(11):995-1011

The American Association of Clinical Endocrinologists (AACE) has created a dysglycemia-based chronic disease (DBCD) multimorbidity care model consisting of four distinct stages along the insulin resistance-prediabetes-type 2 diabetes (T2D) spectrum that are actionable in a preventive care paradigm to reduce the potential impact of T2D, cardiometabolic risk, and cardiovascular events. The controversy of whether there is value, cost-effectiveness, or clinical benefit of diagnosing and/or managing the prediabetes state is resolved by regarding the problem, not in isolation, but as an intermediate stage in the continuum of a progressive chronic disease with opportunities for multiple concurrent prevention strategies. In this context, stage 1 represents "insulin resistance," stage 2 "prediabetes," stage 3 "type 2 diabetes," and stage 4 "vascular complications. Read More

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http://dx.doi.org/10.4158/PS-2018-0139DOI Listing
November 2018

Molecular control of protein synthesis, glucose metabolism, and apoptosis in the brain of hibernating thirteen-lined ground squirrels.

Biochem Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

Carleton University, 6339, Biology , 1125 Colonel By Drive , Ottawa, Ontario, Canada , K1S 5B6 ;

Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) are excellent models for studying acute brain ischemia since they show high resistance to reductions in blood flow and oxygen delivery without evidence of neurological damage. In the present study, we analyzed the insulin signaling pathway and regulation of mitochondrial substrate oxidation in three regions of ground squirrel brain (forebrain, cerebellum, and brainstem), comparing summer, late torpor, and interbout arousal conditions. We found select decreases in phospho-Akt in the cerebellum during torpor as compared to summer animals, as well as select increases in the forebrain during interbout arousal, suggesting that Akt may influence either metabolism or cytoprotective pathways. Read More

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http://dx.doi.org/10.1139/bcb-2018-0256DOI Listing
February 2019

3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signalling pathways.

Mol Pharm 2019 Feb 14. Epub 2019 Feb 14.

3β,23,28-Trihydroxy-12-oleanene 3β-caffeate (compound 1) is a neuritogenic pentacyclic triterpenoid, which was isolated from Desmodium sambuense based on a PC12 cell bioassay system. Compound 1 induced neurite outgrowth dose-dependently in PC12 cells and primary cortical neurons at doses of 0.1, 0. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00939DOI Listing
February 2019

Multifocal fatty liver disease, insulin resistance and carotid atherosclerosis: exploring the interrelated relationship.

J Ultrason 2018 ;18(75):302-309

Diagnostic Radiology Department, Tanta University , Tanta , Egypt.

Multifocal fatty liver infiltrations are not uncommon ultrasonographic finding; they are explained by the presence of aberrant vascular supply independent of the portal circulation or insulin resistance. To study the significance of this ultrasonographic finding. A study group ( = 96) with multifocal fatty liver and two control groups: healthy subjects ( = 100) and patients with diffuse fatty liver disease ( = 100) were enrolled. Read More

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http://dx.doi.org/10.15557/JoU.2018.0044DOI Listing
January 2018

[Exposure of beta-cells to chronic fructose potentiates glucose-stimulated insulin secretion through ATP signaling].

Rev Med Suisse 2019 Feb;15(638):390-392

Département de physiologie cellulaire et métabolisme et Centre facultaire du diabète, Université de Genève, CMU, 1211 Genève 4.

While the use of fructose as a sweetener and its consumption are associated with increased fat storage prompted by the action of insulin, fructose alone does not acutely stimulate insulin exocytosis from the pancreatic beta-cell, as opposed to the chief secretagogue glucose. We investigated the effects of chronic exposure to fructose on beta-cell function. Our results reveal that chronic fructose induces extracellular ATP signaling in the beta-cell, resulting in the potentiation of glucose-stimulated insulin secretion. Read More

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February 2019

Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High-Fat Diet-Fed Mice.

Mol Nutr Food Res 2019 Feb 14:e1801307. Epub 2019 Feb 14.

J. Xu, T. Liu, Y. Li, W. Liu, Z. Ding, Y. Mu1, X. Huang, and L. Li, Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110169, P. R. China.

Scope: Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In the current study, we investigated whether a standardized extract from Jamun (Eugenia jambolana), a widely consumed tropical fruit, could alleviate obesity and alter gut microbial community in high-fat diet (HFD)-fed mice.

Methods And Results: C57BL/6 mice were fed either a standard diet (SD) or HFD with or without Jamun fruit extract (JFE; 100 mg/kg/day) by oral gavage for 8 weeks. Read More

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http://dx.doi.org/10.1002/mnfr.201801307DOI Listing
February 2019

IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14587

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.

Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a pathogenic role in insulin resistance and (IR) and type 2 diabetes (T2D).In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement of IR in RA patients with comorbid T2D and the possible effects on selected serum adipokines. RA patients with comorbid T2D were recruited among those undergoing treatment with anakinra (ANA) or with TNF inhibitor (TNFi). Read More

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http://dx.doi.org/10.1097/MD.0000000000014587DOI Listing
February 2019

The correlation between oxidative stress level and intra-abdominal fat in obese males.

Medicine (Baltimore) 2019 Feb;98(7):e14469

Department of Endocrinology.

This study aims to investigate the correlation between oxidative stress and intra-abdominal fat (IAF) in obese young and middle-aged males.The present study included 136 male examinees in the Examination Center of the First Hospital of Qinhuangdao from October 10, 2015 to December 10, 2015. Then, clinical data, oxidative stress indices (8-iso-prostaglandin F2α [8-iso-PGF2α], malondialdehyde [MDA], and superoxide dismutase [SOD]), and IAF area were recorded. Read More

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http://dx.doi.org/10.1097/MD.0000000000014469DOI Listing
February 2019

RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells.

Islets 2019 Feb 14:1-11. Epub 2019 Feb 14.

b Department of Clinical Science, Division of Islet Cell Physiology , Lund University , Malmö , Sweden.

Little is known about the expression and function of Retinoic acid-related orphan receptors (RORA, B, and C) in pancreatic β cells. Here in, we utilized cDNA microarray and RNA sequencing approaches to investigate the expression pattern of ROR receptors in normal and diabetic human pancreatic islets. Possible correlations between RORs expression and HbA levels as well as insulin secretory capacity in isolated human islets were evaluated. Read More

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http://dx.doi.org/10.1080/19382014.2019.1566684DOI Listing
February 2019

Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters

Turk J Med Sci 2019 Feb 11;49(1):110-115. Epub 2019 Feb 11.

Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS).

Materials And Methods: Fifty-three patients and 26 healthy controls were included in this study. Read More

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http://dx.doi.org/10.3906/sag-1712-192DOI Listing
February 2019

Body Weight and eGFR during Dulaglutide Treatment in Type 2 Diabetes and Moderate-to-Severe Chronic Kidney Disease (AWARD-7).

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

Eli Lilly and Company, Indianapolis, IN, USA.

In patients with T2D and moderate-to-severe CKD, dulaglutide treatment led to body weight (BW) loss and lesser eGFR decline compared to insulin glargine. Since BW may affect muscle mass, creatinine-based eGFR can be altered independent of kidney function. Cystatin C-based eGFR is not affected by muscle mass. Read More

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http://dx.doi.org/10.1111/dom.13668DOI Listing
February 2019

Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980.

Arch Womens Ment Health 2019 Feb 14. Epub 2019 Feb 14.

Forensic Psychiatry, Helsinki University and Helsinki University Hospital, Psykiatriakeskus, P.O. Box 590, 00029, HUS, Finland.

To assess psychosocial and somatic risk factors related to pregnancy, and pregnancy-related complications or disorders in women with schizophrenia compared to population controls. In this register-based cohort study, we identified all Finnish women who were born in 1965-1980 and diagnosed with schizophrenia in psychiatric care before 31 December 2013. For each case, five age- and place-of-birth matched controls were randomly selected. Read More

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http://dx.doi.org/10.1007/s00737-019-0948-0DOI Listing
February 2019

Rapid transport of insulin to the brain following intranasal administration in rats.

Neural Regen Res 2019 Jun;14(6):1046-1051

Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.

We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against 6-hydroxydopamine neurotoxicity in rats. This study aimed to assess insulin pharmacokinetics in the rat brain following intranasal application. Recombinant human insulin (rh-Ins) or phosphate buffer solution was administered to both nostrils of rats. Read More

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http://dx.doi.org/10.4103/1673-5374.250624DOI Listing

Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic -infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0982DOI Listing
February 2019

The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Turk J Med Sci 2019 Feb 11;49(1):238-244. Epub 2019 Feb 11.

Background/aim: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels.

Materials And Methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. Read More

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http://dx.doi.org/10.3906/sag-1806-44DOI Listing
February 2019

The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity

Turk J Med Sci 2019 Feb 11;49(1):245-248. Epub 2019 Feb 11.

Background/aim: In this study, our aim was to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity.

Materials And Methods: Ninety-six patients and 40 healthy controls were included in this study. Patients’ blood glucose levels, insulin levels, and hemogram parameters upon 8 h of fasting were determined. Read More

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http://dx.doi.org/10.3906/sag-1804-68DOI Listing
February 2019

Determining the insulin secretion potential for certain specific G-protein coupled receptors in MIN6 pancreatic beta cells

Turk J Med Sci 2019 Feb 11;49(1):403-411. Epub 2019 Feb 11.

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic β-cell function.

Materials And Methods: Insulin secretion from mouse insulinoma β-cell line (MIN6) monolayers was assessed via insulin radioimmu-noassay (RIA). Read More

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http://dx.doi.org/10.3906/sag-1712-147DOI Listing
February 2019

[Vitamin D deficiency, metabolic syndrome, and prostate adenoma: current epidemiological trends and pathophysiological mechanisms of interaction].

Urologiia 2018 Oct(4):179-185

Kursk State Medical University of Minzdrav of Russia, Kursk, Russia.

This review, based on the results of modern epidemiological and clinical-experimental studies, highlights the important pathophysiological role of vitamin D and the disturbances of its metabolism (deficiency/insufficiency) in the pathogenesis of the metabolic syndrome (MS) in men, which according to available literature, is associated with adenoma of the prostate (AP). General information about the endocrinology of vitamin D and its role in maintaining various aspects of mens health is presented. The authors analyze currently known pathophysiological mechanisms involving vitamin D interacting with each other within the framework of the pathogenesis of MS and AP. Read More

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October 2018

Superior Efficacy of Insulin Degludec/Liraglutide versus Insulin Glargine U100 as Add-on to Sodium-Glucose Co-Transporter-2 Inhibitor Therapy: a Randomized Clinical Trial in Patients with Uncontrolled Type 2 Diabetes.

Diabetes Obes Metab 2019 Feb 13. Epub 2019 Feb 13.

Western University, London, Ontario, Canada.

Aims: Progression of type 2 diabetes (T2D) necessitates intensification, often involving sequential combination of oral antidiabetic drugs (OADs) before initiation of insulin-based therapy. The DUAL IX trial (clinicaltrials.gov: NCT02773368) investigated the efficacy and safety of insulin degludec/liraglutide (IDegLira), vs insulin glargine 100 units/mL (IGlar U100), as add-on to sodium-glucose co-transporter-2 (SGLT2) inhibitor therapy. Read More

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http://dx.doi.org/10.1111/dom.13666DOI Listing
February 2019

Effect of Cilostazol, a Phosphodiesterase-3 Inhibitor, on Coronary Artery Stenosis and Plaque Characteristics in Patients with Type 2 Diabetes (ESCAPE Study).

Diabetes Obes Metab 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.

Aim: Cilostazol is an antiplatelet agent with multiple beneficial metabolic effects via inhibition of phosphodiesterase-3 in vascular smooth muscle cells, cardiomyocytes, adipose tissue, and platelets. We performed a prospective study to evaluate the effect of cilostazol compared with aspirin in Korean diabetic patients with subclinical coronary atherosclerosis.

Materials And Methods: One hundred diabetic patients who had mild-to-moderate coronary atherosclerosis assessed by coronary computed tomographic angiography were randomly assigned to either 200 mg/day cilostazol(CTZ) or 100 mg/day aspirin(ASA) groups (n=50 each). Read More

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http://doi.wiley.com/10.1111/dom.13667
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http://dx.doi.org/10.1111/dom.13667DOI Listing
February 2019

Review of Leipzig protocol for intravenous insulin infusion in pediatric patients with type 1 diabetes during intercurrent illness and surgery.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Diabetology, University of Leipzig, Hospital for Children and Adolescents, 04103 Leipzig, Sachsen, Germany.

Objective: Continuous intravenous (IV) insulin infusion therapy minimizes blood glucose (BG) fluctuations and prevents metabolic deterioration in pediatric patients with type 1 diabetes (T1D) during intercurrent illness and surgery. However, data on the adequate fluid and insulin substitution in this situation is rare. We evaluated the effectiveness and safety of IV insulin therapy according to our local protocol. Read More

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http://dx.doi.org/10.1111/pedi.12830DOI Listing
February 2019

Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.

Respirology 2019 Feb 13. Epub 2019 Feb 13.

Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background And Objective: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. Read More

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http://dx.doi.org/10.1111/resp.13486DOI Listing
February 2019

Insulin-like growth factor-I promotes hepatic differentiation of human adipose tissue-derived stem cells.

Cell Biol Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

There are numerous studies which provide support for the use of human adipose tissue-derived stem cells (hASCs) to generate hepatocyte-like cells. However, the produced cells exhibit only a certain level of differentiation, mainly due to inefficient induction conditions. Therefore, based on the important role of insulin-like growth factor (IGF-I) in hepatic function and development, in the current study we evaluated the differentiation efficacy of the mentioned factor to induce hASCs into functional hepatocyte-like cells. Read More

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http://dx.doi.org/10.1002/cbin.11113DOI Listing
February 2019

Assessing patient-reported outcomes for automated insulin delivery systems: the psychometric properties of the INSPIRE measures.

Diabet Med 2019 Feb 14. Epub 2019 Feb 14.

Bournemouth University, Bournemouth, UK.

Aim: Participants in clinical trials assessing automated insulin delivery systems report perceived benefits and burdens that reflect their experiences and may predict their likelihood of uptake and continued use of this novel technology. Despite the importance of understanding their perspectives, there are no available validated and reliable measures assessing the psychosocial aspects of automated insulin delivery systems. The present study assesses the initial psychometric properties of the INSPIRE measures, which were developed for youth and adults with Type 1 diabetes, as well as parents and partners. Read More

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http://dx.doi.org/10.1111/dme.13930DOI Listing
February 2019

Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3.

AAPS J 2019 Feb 13;21(2):30. Epub 2019 Feb 13.

Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA.

Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body. We earlier established that activation of protein kinase C (PKC) enhances OAT3 ubiquitination, which promotes OAT3 internalization from the cell plasma membrane to intracellular endosomes and consequent degradation. As a result, OAT3 expression and transport activity are reduced. Read More

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http://dx.doi.org/10.1208/s12248-019-0303-4DOI Listing
February 2019

Impact of pituitary dysfunction on cognitive and global outcome after traumatic brain injury and aneurysmal subarachnoid haemorrhage.

J Rehabil Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, , Stockholm, Sweden.

Objective: To explore associations between pituitary dysfunction and clinical outcome at 12 months after traumatic brain injury and aneurysmal subarachnoid haemorrhage.

Methods: Prospective cohort study of 82 patients with traumatic brain injury and 45 with aneurysmal subarachnoid haemorrhage, included at 1 neurointensive care unit. Baseline data comprised age, sex, Glasgow Coma Scale (GCS) score, S100B and pupil light reactions. Read More

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http://dx.doi.org/10.2340/16501977-2531DOI Listing
February 2019

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.

FEBS Open Bio 2019 Feb 19;9(2):348-363. Epub 2019 Jan 19.

Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Harvard Medical School Charlestown MA USA.

Mitochondrial dysfunction is associated with metabolic alterations in various disease states, including major trauma (e.g., burn injury). Read More

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http://dx.doi.org/10.1002/2211-5463.12580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356165PMC
February 2019

Impact of Gut Microbiota on Host Glycemic Control.

Front Endocrinol (Lausanne) 2019 30;10:29. Epub 2019 Jan 30.

Univ Lyon, CarMeN Laboratory, INSERM U1060, INRA U1397, INSA Lyon, Université Claude Bernard Lyon1, Oullins, France.

Given that obesity and associated disorder type II diabetes mellitus have reached epidemic proportions worldwide, the development of efficient prevention and therapeutic interventions is a global public health interest. There is now a large body of evidence suggesting that the micro-organisms colonizing the human gut, known as gut microbiota, play a central role in human physiology and metabolism. Understanding how gut microbiota affects and regulates key metabolic functions such as glucose regulation and insulin resistance is an important health issue. Read More

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http://dx.doi.org/10.3389/fendo.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363653PMC
January 2019

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.

Front Endocrinol (Lausanne) 2019 28;10. Epub 2019 Jan 28.

Genetics and Bioinformatics Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.

Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an increased risk for metabolic disorders. Unlike the European population, the Arab population lacks well-established genetic risk determinants for metabolic disorders, and the transferability of established risk loci to this population has not been satisfactorily demonstrated. The most recent findings have identified over 240 genetic risk loci (with ~400 independent association signals) for type 2 diabetes, but thus far only 25 risk loci (, ALX4, , COL8A1, γ, and ) have been replicated in Arab populations. Read More

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http://dx.doi.org/10.3389/fendo.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362414PMC
January 2019

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Nature 2019 Feb 13. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing cells after the ablation of insulin-secreting β-cells, thus promoting diabetes recovery. Whether human islets also display this plasticity, especially in diabetic conditions, remains unknown. Read More

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http://dx.doi.org/10.1038/s41586-019-0942-8DOI Listing
February 2019

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.

Nat Rev Endocrinol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Gut hormones have many key roles in the control of metabolism, as they target diverse tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation and food intake. Produced by scattered cells found along the length of the intestinal epithelium, gut hormones generate signals related to the rate of nutrient absorption, the composition of the luminal milieu and the integrity of the epithelial barrier. Gut hormones already form the basis for existing and developing therapeutics for type 2 diabetes mellitus and obesity, exemplified by the licensed glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl peptidase inhibitors that enhance GLP1 receptor activation. Read More

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http://www.nature.com/articles/s41574-019-0168-8
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http://dx.doi.org/10.1038/s41574-019-0168-8DOI Listing
February 2019
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Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway.

Acta Pharmacol Sin 2019 Feb 13. Epub 2019 Feb 13.

School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.

Microcirculation morphologically refers to the blood flow in vessels of less than 150 μm in diameter, including arterioles, capillaries and venules, which provides nutrients and removes metabolic byproducts within tissues. Microcirculation dysfunction is involved in the pathological progress of many diseases, such as obesity, hypertension, and insulin resistance. In this study we investigated the effects of magnesium lithospermate B (MLB), an active compound of the traditional Chinese medicine Slavia miltiorrhiza, on the microcirculation dysfunction in rats and the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1038/s41401-018-0203-7DOI Listing
February 2019

L-PGDS-produced PGD in premature, but not in mature, adipocytes increases obesity and insulin resistance.

Sci Rep 2019 Feb 13;9(1):1931. Epub 2019 Feb 13.

The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS and adiponectin (AdipoQ)-Cre/L-PGDS mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. Read More

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http://dx.doi.org/10.1038/s41598-018-38453-yDOI Listing
February 2019

Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals.

Sci Rep 2019 Feb 13;9(1):1959. Epub 2019 Feb 13.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská cesta 9, 94505, Bratislava, Slovakia.

Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75-80% HRmax; maximal heart rate), additional serum was taken at finish-line. Read More

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http://dx.doi.org/10.1038/s41598-018-38201-2DOI Listing
February 2019

[Clinical characteristics of bullous pemphigoid in elderly patients with type 2 diabetes mellitus: The association with the use of dipeptidyl peptidase-4 inhibitors].

Nihon Ronen Igakkai Zasshi 2019 ;56(1):43-50

Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital.

Aim: Bullous pemphigoid (BP) is an autoimmune skin disorder characterized by the production of autoantibodies. Several recent reports have described the occurrence of BP in diabetic patients treated with dipeptidyl peptidase-4 (DPP-4) inhibitors. However, the clinical features of BP in diabetic patients, particularly in those treated with DPP-4 inhibitors, have not yet been examined. Read More

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http://dx.doi.org/10.3143/geriatrics.56.43DOI Listing
January 2019

Body mass index and C-peptide are important for the promptly differential diagnosis of maturity-onset diabetes from familial type 2 diabetes in outpatient clinic.

Endocr J 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Metabolism, Hunan provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Type 2 diabetic patients are becoming younger and having a tendency to family aggregation, they are easily suspected as maturity-onset diabetes of young (MODY) in the outpatient clinic and send to genetic testing. 9 diabetic families were compared in our outpatient clinic who met the primary diagnosis criteria of MODY. Detailed clinical features and laboratory data including gene sequence were collected and analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0560DOI Listing
February 2019

Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia.

Schizophr Res 2019 Feb 11. Epub 2019 Feb 11.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

Memory is robustly impaired in schizophrenia (SZ) and related to functional outcome. Memory dysfunction has been shown to be related to altered brain glucose metabolism and brain insulin resistance in animal models and human studies of Alzheimer's disease. In this study, differences in brain glucose using magnetic resonance spectroscopy (MRS) and blood Extracellular Vesicle (EV) biomarkers of neuronal insulin resistance (i. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.031DOI Listing
February 2019

The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells.

Stem Cell Res Ther 2019 Feb 13;10(1):53. Epub 2019 Feb 13.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include the potential for growing tissues and organs in the laboratory and transplanting them when the body cannot heal itself. However, several obstacles remain to be overcome in order to bring regenerative medicine approach for diabetes closer to its clinical implementation; the cells generated in vitro are typically of heterogenic and immature nature and the site of implantation should be readily vascularized for the implanted cells to survive in vivo. Read More

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http://dx.doi.org/10.1186/s13287-019-1157-5DOI Listing
February 2019

Systematic thyroid screening in myotonic dystrophy: link between thyroid volume and insulin resistance.

Orphanet J Rare Dis 2019 Feb 13;14(1):42. Epub 2019 Feb 13.

CHU Lille, Endocrinology, Diabetology and Metabolism, F-59000, Lille, France.

Background: Myotonic dystrophy (DM1), a neuromuscular disease related to DMPK gene mutations, is associated to endocrine disorders and cancer. A routine endocrine work-up, including thyroid ultrasound (US), was conducted in 115 genetically-proven DM1 patients in a neuromuscular reference center. The aim of this study was to determine the prevalence and the causes of US thyroid abnormalities in DM1. Read More

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http://dx.doi.org/10.1186/s13023-019-1019-3DOI Listing
February 2019