Search Our Scientific Publications & Authors

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacy, National University of Singapore, Singapore.

Cancer-related fatigue (CRF) is subjective and has wide inter-individual variability. Given that leptin is commonly associated with fatigue syndrome, its use as a potential biomarker for CRF is being investigated. The primary objective of this study was to evaluate the association between leptin and CRF in early-stage breast cancer patients receiving chemotherapy. Read More

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

1 Beijing University of Chinese Medicine, Beijing, China.

Acupuncture as one of the alternative therapies for insomnia is widely used in Asia and increasingly employed in western countries. To provide updated evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture for primary insomnia. A comprehensive literature search in 11 databases was conducted from January 2008 to October 2017. Read More

Brain Imaging Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305#, Eastern Zhongshan Rd, Nanjing, 210002, Jiangsu, People's Republic of China.

To identify altered inter-hemispheric communication between patients with primary insomnia (PIs) and good sleepers (GSs), and their relationships with sleep and emotion-related parameters. Forty-eight PIs and 48 status-matched GSs were asked to complete a number of sleep and emotion-related questionnaires. Voxel-mirrored homotopic connectivity(VMHC) and seed-based functional connectivity were used to characterize the inter-hemispheric coordination. Read More

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):199-202

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: A large proportion of the population suffers from disturbed sleep and a majority of these present to clinicians with the complaint of insomnia. Many of these people possibly suffer from other primary sleep disorders such as sleep apnea; however, insomnia disorder also remains an extremely common condition directly impacting the quality of life and work efficiency of affected people. While a number of approaches are used for treatment by many clinicians, a much smaller percentage can seek help from specialty sleep clinics. Read More

Behav Sleep Med 2019 Apr 21:1-14. Epub 2019 Apr 21.

a Division of cardiac prevention and rehabilitation , University of Ottawa Heart Institute , Ottawa , ON , Canada.

Objective: There is little research assessing the use of cognitive-behavioral therapy for insomnia (CBT-I) among patients with cardiovascular disease (CVD), even less on the effects of CBT-I on CVD risk factors such as anxiety and depression, and to our knowledge, only limited studies of the efficacy of CBT-I protocols with cardiac disease-specific modifications. The objective of this study is to evaluate a group-based CBT-I intervention tailored to patients with CVD on sleep quality, duration, and mental health.

Participants: A sample of 47 participants (25 men) diagnosed with primary insomnia were included in this study. Read More

Am J Cardiol 2019 Mar 18. Epub 2019 Mar 18.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.

Female cardiac patients are at greater risk for mental health disorders than their male counterparts, and these mental health disorders have been associated with increased cardiac morbidity and mortality. However, few studies have closely examined the mental health disorders found among the female cardiac population. The primary aim of this study was to examine the prevalence of psychological distress in a sample of female cardiac outpatients at an academic medical center. Read More

BMJ Open 2019 Apr 20;9(4):e021484. Epub 2019 Apr 20.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: Sleep disorders including insomnia occur frequently in depressive patients. Acupuncture is a widely recognised therapy to treat depression and sleep disorders in clinical practice. This multicentre randomised controlled trial (RCT) is aimed to investigate the efficacy and safety of electroacupuncture (EA) in the treatment of depression patients with insomnia. Read More

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

J Palliat Med 2019 Apr 17. Epub 2019 Apr 17.

1 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

Therapeutic cannabis is being more widely used by patients to manage multiple symptoms, but the patterns of use in the palliative care population are not well defined. The primary aim of this pilot study was to describe the use of cannabis among patients attending a palliative care clinic (PCC). The study was a retrospective chart review of patients seen at four different interval points during 2017 and 2018 in an ambulatory palliative care setting. Read More

Cochrane Database Syst Rev 2019 Apr 12;4:CD012680. Epub 2019 Apr 12.

School of Psychology, Deakin University Geelong, 221 Burwood Highway, Burwood, VIC, Victoria, Australia, 3025.

Background: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD. Read More

J Med Internet Res 2019 Apr 11;21(4):e12686. Epub 2019 Apr 11.

Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: In reality, pharmacotherapy still remains the most common treatment for insomnia.

Objective: This study aimed to examine the effectiveness of our internet-delivered computerized cognitive behavioral therapy (ICBT) program as an adjunct to usual care (UC) compared with UC alone in patients with insomnia who remain symptomatic following hypnotics.

Methods: We recruited 23 patients with insomnia who remained symptomatic following pharmacologic treatment including benzodiazepines, and we conducted an exploratory randomized controlled trial. Read More

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Stanford University, Stanford, California; Monash University, Melbourne, Australia; and Santa Clara Valley Medical Center, Fruitdale, California.

Objective: To evaluate the effectiveness of cognitive behavioral therapy for insomnia during pregnancy.

Methods: Randomized, unmasked, 3-site controlled trial. Participants were randomly allocated to cognitive behavioral therapy for insomnia (a first-line, empirically supported psychosocial intervention that addresses sleep-related behaviors and cognitions) or a control intervention consisting of imagery exercises that paired patient-identified distressing nighttime experiences with patient-identified neutral images. Read More

Am J Health Promot 2019 Apr 7:890117119841407. Epub 2019 Apr 7.

3 Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.

Objective: Workplace-based employee health promotion programs often target weight loss or physical activity, yet there is growing attention to sleep as it affects employee health and performance. The goal of this review is to systematically examine workplace-based employee health interventions that measure sleep duration as an outcome.

Data Source: We conducted systematic searches in PubMed, Web of Knowledge, EMBASE, Scopus, and PsycINFO (n = 6177 records). Read More

Mil Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Sleep Medicine, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX.

Introduction: Excessive daytime sleepiness affects an estimated 20% of the general population. While the prevalence of sleepiness in the military is largely unknown, it is well established that short sleep duration is endemic. The reasons for this include: the demanding nature of their duties, shift work and 24-hour duty periods, deployments and exigencies of military service as well as sleep disorders. Read More

Internet Interv 2019 Sep 10;17:100236. Epub 2019 Feb 10.

Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.

Background: Internet-delivered interventions can provide remarkable opportunities in addressing breast cancer survivors' unmet support care needs, as they present an effective strategy to improve care coordination and provide access to efficacious, cost-efficient and convenient survivorship care. Nevertheless, research focusing on improving survivors' psychosocial needs using internet-based tools is scarce and its practical implementation is limited.

Objectives: To study the acceptability, feasibility, efficacy and cost-effectiveness of iNNOVBC, a 10 weeks guided internet-delivered individually-tailored Acceptance and Commitment Therapy (ACT)-influenced cognitive behavioural (CBT) intervention developed to improve mild to moderate anxiety and depression in Breast cancer survivors when compared to treatment as usual (TAU) in a waiting list control group (WLC). Read More

Acta Med Port 2019 Mar 29;32(3):189-194. Epub 2019 Mar 29.

Pharmacy and Therapeutics Committee. Centro Hospitalar de Lisboa Ocidental. Lisboa. Portugal.

Introduction: In late 2014, Portugal implemented a national program for the treatment of patients with chronic hepatitis C with directacting antiviral agents. This program has made Portugal one of the first European countries to implement a structured measure of treatment to eliminate this serious public health problem. The aim of this study was to assess the effectiveness of direct-acting antiviral therapy in the treatment of patients with chronic hepatitis C virus infection. Read More

J Clin Psychopharmacol 2019 May/Jun;39(3):203-209

H. Lundbeck A/S, Valby, Denmark.

Background: Long-term treatment is recommended in major depressive disorder (MDD) to prevent relapse and to restore functioning. The aim of this study (Orion; NCT01360866) was to assess the long-term safety, tolerability, and efficacy of open-label treatment with adjunctive brexpiprazole in adult patients with MDD.

Methods: Patients rolled over into this 52-week study (amended to 26 weeks) from 3 randomized, double-blind, placebo-controlled studies. Read More

Complement Ther Med 2019 Apr 9;43:53-59. Epub 2019 Jan 9.

93/2/1, Shibpur Road, PO and PS Shibpur, Howrah 711102, West Bengal, India. Electronic address:

Background: Insomnia is the most common sleep-related complaint associated with impaired day-time functioning, reduced quality of life, increased morbidity and substantial societal cost. We evaluated whether individualized homeopathy (IH) could produce significant effect beyond placebo in treatment of insomnia.

Methods: In this double-blind, randomized, placebo-controlled, two parallel arms trial, 60 patients were randomized to receive either IH/verum or control/placebo (1:1). Read More

J Sleep Res 2019 Mar 31:e12847. Epub 2019 Mar 31.

Normandie Univ, UNICAEN, INSERM, COMETE, 14000, Caen, France.

According to epidemiological studies, insomnia is associated with an increase in risk of traffic accidents. Recent investigations revealed that patients with insomnia had driving performance impairment under monotonous conditions. However, it is unclear whether other driving abilities may be impacted by insomnia, especially those needing more attentional resources than those involved in monotonous driving. Read More

J Psychother Integr 2018 Sep;28(3):292-309

Alabama Neurology and Sleep Medicine, Tuscaloosa, AL.

Background: We examined the effects of integrated cognitive-behavioral therapy for depression and insomnia (CBT-D + CBT-I) delivered via videoconferening in rural, middle aged and older adults with depressive and insomnia symptoms.

Method: Forty patients with depressive and insomnia symptoms were randomized to receive either 10 sessions of CBT-D + CBT-I or usual care (UC). Patients in the integrated CBT condition were engaged in telehealth treatment through Skype at their primary care clinic. Read More

J Affect Disord 2019 Mar 22;251:186-194. Epub 2019 Mar 22.

Departments of Health Promotion and Human Behavior and of Clinical Epidemiology, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan. Electronic address:

Background: The efficacy of the mindfulness-based stress management program for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of the brief mindfulness-based stress management program for hospital nurses.

Methods: In a multi-center randomized trial, 80 junior nurses working in hospitals were randomly allocated either to the brief mindfulness-based stress management program or psychoeducation using a leaflet. Read More

Alcohol Clin Exp Res 2019 Mar 26. Epub 2019 Mar 26.

Cpl. Michael J. Crescenz VA Medical Center, Philadelphia, PA.

Background: Insomnia is highly prevalent in individuals recovering from Alcohol Dependence (AD) and increases their risk of relapse. Two studies evaluating Cognitive Behavioral Therapy for Insomnia (CBT-I) have demonstrated its efficacy in non-Veterans recovering from AD. The aim of this study was to extend these findings in an 8-week trial of CBT-I in Veterans. Read More

Behav Sleep Med 2019 Mar 24:1-14. Epub 2019 Mar 24.

d Jennifer Wisdom Consulting , New York , New York.

Objective/background: Cognitive behavioral therapy for insomnia (CBT-I) is the most effective treatment for insomnia but is severely underutilized. One of the key reasons for underuse is lack of knowledge among patients and primary care providers, but effective methods and materials for increasing knowledge are unknown. This study conducted in-depth interviews with CBT-I patients and their CBT-I providers to explore their perceptions on increasing utilization of CBT-I. Read More

Res Gerontol Nurs 2019 Mar 22:1-7. Epub 2019 Mar 22.

The feasibility and preliminary efficacy of a mobile health self-management intervention aimed at improving sleep among older adults with osteoarthritis and disturbed sleep were evaluated. This was a one-group pre-/posttest pilot study. Feasibility was measured by the number of participants eligible, enrolled, and retained. Read More

Neuroimage Clin 2019 Mar 4;22:101745. Epub 2019 Mar 4.

Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA. Electronic address:

Background: Primary insomnia (PI) is one of the most common complaints among the general population. Both non-pharmacological and pharmacological therapies have proven effective in treating primary insomnia. However, the underlying mechanism of treatment remains unclear, and no studies have compared the underlying mechanisms of different treatments. Read More

J Clin Hypertens (Greenwich) 2019 Mar 15. Epub 2019 Mar 15.

Jichi Medical University School of Medicine, Tochigi, Japan.

Orexins are neuropeptides that play a role in maintaining wakefulness and contribute to central regulation of cardiovascular function. This first multicenter, randomized, double-blind study investigated the effects of suvorexant, a reversible dual orexin receptor antagonist, on nighttime blood pressure (BP) in patients with insomnia and hypertension. After a 4-week run-in period, adult outpatients (n = 82) with treated hypertension (clinic SBP <160 mm Hg) and insomnia were treated with suvorexant 20 mg/d or placebo before bedtime for 2 weeks. Read More

Sleep Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China. Electronic address:

Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method, and its application in the treatment of primary insomnia (PI) is poorly researched. PI is considered to be a functional disorder with abnormal brain network connections. TMS combined electroencephalography (EEG) is a valuable method for directly probing excitability and dynamic connectivity of different regions in the brain. Read More

Sleep Med 2019 Jan 31. Epub 2019 Jan 31.

École de psychologie, Université Laval, Québec, QC, Canada; Centre de recherche CERVO, Québec, QC, Canada. Electronic address:

Objectives: To examine the potential moderating effect of objectively measured sleep duration at baseline on the response to cognitive behavioral therapy for insomnia (CBT-I), administered singly or combined with medication (CBT-I + Med).

Methods: Based on the average PSG-derived sleep duration across two baseline nights and the type of treatment received, 159 adults with insomnia (50.3 ± 10. Read More

J Transl Med 2019 Mar 12;17(1):77. Epub 2019 Mar 12.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129, Perugia, Italy.

Background: There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the efficacy and safety of melatonin in treating pediatric insomnia and sleep disturbances.

Main Body: Sleep disturbances are highly prevalent in children and, without appropriate treatment, can become chronic and last for many years; however, distinguishing sleep disturbances from normal age-related changes can be a challenge for physicians and may delay treatment. Read More

J Food Sci 2019 Apr 13;84(4):904-910. Epub 2019 Mar 13.

Xiangya Hospital, Central South Univ., Changsha, China.

Imatinib, the prototype BCR-ABL tyrosine kinase inhibitor (TKI), is the first-line treatment for Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase. However, a subgroup of patients exhibit poor response or experience relapse. This issue may be overcome by combination therapy using natural compounds. Read More

CNS Spectr 2019 Feb;24(1):219-220

Tris Pharma,Inc.,Monmouth Junction,NJ.

OBJECTIVESTo determine the efficacy and safety of amphetamine extended-release oral suspension (AMPH EROS) in the treatment of attention-deficit/hyperactivity disorder (ADHD) compared with placebo in a dose-optimized, randomized, double-blind study.METHODSThe efficacy of AMPH EROS was evaluated in a laboratory classroom study conducted in 108 pediatric patients (aged 6-12 years) with ADHD. The study began with an open-label dose optimization (5weeks) with an initial AMPH EROS dose of 2. Read More

CNS Spectr 2019 Feb;24(1):218-219

1Meridien Research,Bradenton,FL.

Objectives: Report the efficacy of open-label amphetamine extended-release oral suspension (AMPH EROS) for the treatment of children with ADHD.AMPH EROS has a 1-hr onset of effect and a duration of action of 13hours and was approved by FDA for treatment of ADHD in children aged 6-17 years based on a double-blind, placebo-controlled efficacy and safety study in children aged 6-12 years with ADHD. A significant treatment difference in change from pre-dose SKAMP-combined score was observed at the primary endpoint of 4hours post-dose (p5%) reported during dose optimization were decreased appetite, insomnia, affect lability, upper abdominal pain, mood swings and headache. Read More

Aten Primaria 2019 Mar 8. Epub 2019 Mar 8.

Unidad Docente Multiprofesional de Atención Familiar y Comunitaria, Gerencia de Atención Primaria de Mallorca, Ibsalut, Islas Baleares, España; Instituto de Investigación Sanitaria de las Islas Baleares (idISBA), Palma de Mallorca, Islas Baleares.

Objectives: To estimate insomnia prevalence as well as habits comorbidity, sleep quality of insomnia patients.

Design: Cross sectional descriptive study.

Setting: Calvia health center (Majorca, Spain). Read More

Neurologia 2019 Mar 8. Epub 2019 Mar 8.

Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Motion in Brains Research Group, Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Instituto de Neurociencia y Dolor Craneofacial (INDCRAN), Madrid, España; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, España.

Introduction: One of the factors contributing to transformation of migraine are sleep disorders, which can act as a trigger and/or perpetuating factor in these patients. This study's primary objective was to identify predictive factors related to sleep quality in patients with chronic migraine (CM); the secondary objective was to identify any differences in psychological variables and disability between patients with CM with better or poorer sleep quality.

Methods: A total of 50 patients with CM were included in an observational, cross-sectional study. Read More

Evid Based Complement Alternat Med 2019 3;2019:2543413. Epub 2019 Feb 3.

Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China.

Objectives: This study investigated the distribution of characteristics of traditional Chinese medicine syndromes and their association with symptoms in 1027 patients with chronic heart failure (CHF).

Methods: An observational study was performed by researchers, collecting data from 1036 patients with CHF from 24 Chinese medicine hospitals from May 2009 to December 2014. Due to incomplete information from nine patients, 1027 patients with CHF were analysed. Read More

Psychiatry Res 2019 04 1;274:383-390. Epub 2019 Mar 1.

Birkbeck Centre for Medical Humanities, Birkbeck, University of London, London, UK.

Prevalence studies show high levels of burnout, anxiety, fatigue and other symptoms of distress among medical doctors. However, there are very few randomized controlled trials testing interventions against these problems. This randomized controlled trial (NCT02838290; ClinicalTrials. Read More

Sleep Med 2019 Jan 30. Epub 2019 Jan 30.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

Objective: Little is known about the prevalence and impact of insomnia on clinical outcomes in youth with obsessive-compulsive disorder (OCD). This study aimed to investigate this subject.

Patients/methods: A total of 193 patients from a specialist pediatric OCD clinic completed a range of diagnostic and clinical measures, including the Insomnia Severity Index (ISI). Read More

Brain Behav Immun 2019 Mar 6. Epub 2019 Mar 6.

Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Objective: Circadian dysfunction is a core manifestation and a risk factor for psychiatric disorders. Ramelteon (RMT), a melatonin receptor agonist, has been shown to induce sleep phase shifts and has been used to normalize sleep onset time. RMT has been used in sleep disorders, depression and anxiety. Read More

Sleep Breath 2019 Mar 8. Epub 2019 Mar 8.

Department of Nursing, College of Applied Medical Sciences, Majmaah University, Al Majmaah, 11952, Saudi Arabia.

Background: Insomnia is the most prevalent sleep disorder, but it is widely untreated and under-diagnosed in Saudi Arabia. Moreover, no tool to screen insomnia has been validated in the Saudi population in general or nurses in particular. This study, therefore, assessed the psychometric validity of the Insomnia Severity Index (ISI) in Saudi nurses. Read More

Handb Exp Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

University of Alabama at Birmingham, Birmingham, AL, USA.

This chapter covers antidepressants that fall into the class of serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors. That is, they bind to the 5-HT and NE transporters with varying levels of potency and binding affinity ratios. Unlike the selective serotonin (5-HT) reuptake inhibitors (SSRIs), most of these antidepressants have an ascending rather than a flat dose-response curve. Read More

Contemp Clin Trials 2019 Apr 27;79:73-79. Epub 2019 Feb 27.

School of Nursing, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

Background: Chronic insomnia is associated with poor asthma control. Cognitive-behavioral treatment for insomnia (CBT-I) is an efficacious and durable treatment for comorbid insomnia in medical and psychiatric disorders. However, the efficacy and potential accompanying mechanisms of CBT-I have not been examined in asthma. Read More

Neuropsychopharmacology 2019 Mar 1. Epub 2019 Mar 1.

Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, Toulouse, 31000, France.

F17464, a highly potent preferential D3 antagonist, is a novel compound in development for schizophrenia treatment. This phase II, double-blind, randomized, placebo-controlled, parallel-group study in five European countries evaluated the efficacy and safety of F17464, 20 mg twice daily, versus placebo over 6 weeks in patients with acute exacerbation of schizophrenia. Change from baseline to Day 43 of the Positive and Negative Syndrome Scale (PANSS) total score was the primary outcome. Read More

Medicine (Baltimore) 2019 Mar;98(9):e14693

Radiotherapy Center, No. 323 Hospital of People's Liberation Army, Xi'an, China.

An increasingly important concern for clinicians who care for patients with cancers is their psychological problems and quality of life. The present study examined the efficacy of supportive group psychotherapy (SGP) on anxiety, depression and overall quality of life in patients with lung cancer undergoing gamma knife surgery (GKS).160 patients with lung cancer undergoing GKS were randomly divided into SGP group (n = 82) and care as usual (CAU) group (n = 78). Read More

Medicine (Baltimore) 2019 Feb;98(8):e14621

Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Background: Primary insomnia is one of the common sleep disorders. Auriculotherapy originated from traditional Chinese medicine, has been thought as a promising treatment for primary insomnia. We aim to evaluate the efficacy and safety of auriculotherapy for patients with primary insomnia through this systematic review. Read More

J Public Health (Oxf) 2019 Feb 23. Epub 2019 Feb 23.

Department of Psychology, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Background: Sleep health is a relatively new multidimensional concept, however, there is no consensus on its underlying dimensions. A previous study examined potential indicators of sleep health using an aggregated sleep health measure. However, the psychometric properties are yet to be determined. Read More

Behav Sleep Med 2019 Feb 22:1-13. Epub 2019 Feb 22.

a Division of Behavioral Medicine and Clinical Psychology/Pulmonary Medicine , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio.

Objective/background: This study evaluated the overall performance of the Sleep Disorders Inventory for Students (SDIS) in identifying sleep disorders risk and the sensitivity and specificity of specific SDIS subscales in a clinically referred sample of youth with insomnia.

Participants: Youth (N = 1,329, M = 2.5-18. Read More

Brain 2019 Mar;142(3):744-759

Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada.

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially intervene with neuroprotective therapy. For future neuroprotective trials, it is essential to accurately estimate phenoconversion rate and identify potential predictors of phenoconversion. Read More

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):52-55. Epub 2019 Jan 31.

Department of Anesthesiology, The Third Xiangya Hospital of South Central University, Hunan Province, China.

More and more studies show that inflammation, pain and insomnia have become the main common diseases. Effective treatments of inflammation, pain and insomnia have become an issue of primary concern in clinical practice. Oleuropein (OLE), the main phenolic component of Mediterranean extra virgin olive oil, has shown many pharmacological properties. Read More

Clin Pediatr (Phila) 2019 Feb 19:9922819832030. Epub 2019 Feb 19.

1 Nationwide Children's Hospital, Columbus, OH, USA.

Self-administered treatments may overcome access barriers to evidence-based care for pediatric sleep problems. Two hundred thirty-nine families participated in a randomized controlled trial with 3 study arms: a DVD intervention condition (the Sleep Easy Solution), a Website comparison condition, and a Wait-List comparison condition. The primary outcome was trichotomous-Do you consider your child's sleep a problem? (not a problem at all, a small problem, a very serious problem). Read More