22,800 results match your criteria Insomnia


Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education.

Sleep Med 2018 Dec 28;55:124-134. Epub 2018 Dec 28.

Thomas Roth Sleep Disorders & Research Center, Henry Ford Health System, Detroit, MI, USA. Electronic address:

Introduction: Depression increases during menopause, and subclinical depressive symptoms increase risk for major depression. Insomnia is common among postmenopausal women and increases depression-risk in this already-vulnerable population. Recent evidence supports the efficacy of cognitive-behavioral therapy for insomnia (CBTI) to treat menopausal insomnia, but it remains unclear whether treating insomnia also alleviates co-occurring depressive symptoms and depressogenic features. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.019DOI Listing
December 2018

Assessment of the anti-inflammatory, analgesic and sedative effects of oleuropein from Olea europaea L.

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):52-55. Epub 2019 Jan 31.

Department of Anesthesiology, The Third Xiangya Hospital of South Central University, Hunan Province, China.

More and more studies show that inflammation, pain and insomnia have become the main common diseases. Effective treatments of inflammation, pain and insomnia have become an issue of primary concern in clinical practice. Oleuropein (OLE), the main phenolic component of Mediterranean extra virgin olive oil, has shown many pharmacological properties. Read More

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January 2019

A Randomized Trial of a Self-Administered Parenting Intervention for Infant and Toddler Insomnia.

Clin Pediatr (Phila) 2019 Feb 19:9922819832030. Epub 2019 Feb 19.

1 Nationwide Children's Hospital, Columbus, OH, USA.

Self-administered treatments may overcome access barriers to evidence-based care for pediatric sleep problems. Two hundred thirty-nine families participated in a randomized controlled trial with 3 study arms: a DVD intervention condition (the Sleep Easy Solution), a Website comparison condition, and a Wait-List comparison condition. The primary outcome was trichotomous-Do you consider your child's sleep a problem? (not a problem at all, a small problem, a very serious problem). Read More

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http://dx.doi.org/10.1177/0009922819832030DOI Listing
February 2019

Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer's Disease.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-8502, Japan.

Sleep disturbance is a common symptom in patients with various neurodegenerative diseases, including Alzheimer's disease (AD), and it can manifest in the early stages of the disease. Impaired sleep in patients with AD has been attributed to AD pathology that affects brain regions regulating the sleep⁻wake or circadian rhythm. However, recent epidemiological and experimental studies have demonstrated an association between impaired sleep and an increased risk of AD. Read More

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http://dx.doi.org/10.3390/ijms20040803DOI Listing
February 2019

Network Analysis of Behaviors in the Depression and Autism Realms: Inter-Relationships and Clinical Implications.

J Autism Dev Disord 2019 Feb 18. Epub 2019 Feb 18.

Child Study Center, Yale University School of Medicine, 230 S. Frontage Rd, New Haven, CT, 06519, USA.

Depression-, anxiety-, OCD- and autism-related behaviors were assessed in 118 high-functioning individuals with autism spectrum disorders (ASD) and in 2016 controls. The ASD group had a higher rate of clinical depression and markedly higher "insomnia" and "restlessness" scores. Network analysis and hierarchical cluster analysis in the ASD group revealed that depression and anxiety items clustered together, but separately from autism-related items. Read More

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http://dx.doi.org/10.1007/s10803-019-03914-4DOI Listing
February 2019

Polychromatic Light Exposure as a Therapeutic in the Treatment and Management of Parkinson's Disease: A Controlled Exploratory Trial.

Front Neurol 2018 19;9:741. Epub 2018 Sep 19.

The Bronowski Institute of Behavioural Neuroscience, The Bronowski Clinic, Coliban Medical Centre, Kyneton, VIC, Australia.

Parkinson's disease (PD) is a disorder characterized by loss of dopamine (DA) in the nigro-striatal dopamine (NSD) system with the primary symptoms of bradykinaesia, rigidity, tremor, and altered gate. Secondary symptoms including depression, insomnia, involuntary movement, and psychiatric side effects are also commonly observed. While the treatment focus for the past 50 years has been aimed at replacing deficient DA, to relieve the primary symptoms, more recent studies have suggested that the circadian system plays a critical role in the etiology and treatment of this disorder. Read More

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http://dx.doi.org/10.3389/fneur.2018.00741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156259PMC
September 2018

Insomnia and its associated factors in incarcerated adults: A cross-sectional study.

Nurs Health Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Nursing, Tzu Chi University, Hualien, Taiwan.

No evidence exists in the literature concerning the prevalence of insomnia and its associated risk factors among prison inmates in Taiwan. The aim of the present study was to determine the prevalence and factors associated with insomnia among inmates in a large prison in Taiwan. A cross-sectional anonymous questionnaire survey was conducted at a prison. Read More

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http://dx.doi.org/10.1111/nhs.12600DOI Listing
February 2019
2 Reads

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Neurobiol Aging 2019 Jan 26;77:37-43. Epub 2019 Jan 26.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. Electronic address:

There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast administration (100, 250, 1000 μg) in a double-blind, placebo-controlled, 4-way crossover design. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.014DOI Listing
January 2019

[The sleep in children with neurodevelopmental disorders].

Medicina (B Aires) 2019 ;79 Suppl 1:44-50

Unidad de Pediatría Integral y Sueño, Hospital Quirónsalud, Valencia, Grupo de Sueño de la Sociedad Española de Pediatría Extrahospitalaria y Atención Primaria (SEPEAP), España. E-mail:

Adequate sleep is of critical need for a typical synaptic development and brain maturation, a poor quality sleep can have detrimental effects on children's' cognitive attention, memory, mood regulation, and behavior functions. Great concern has been voiced out regarding the high prevalence of poor sleep in children worldwide, the effects of poor sleep may be even more pronounced in children with neurodevelopmental disorders; these children often have difficulties with falling and staying asleep and with night awakenings, this has a strong association with daytime behavior problems. The purpose of this article is to provide an overview of the state of the science of sleep in children with a neurodevelopmental disorder. Read More

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January 2019

Higher Physical Activity Is Associated With Less Fatigue and Insomnia Among Patients on Hemodialysis.

Kidney Int Rep 2019 Feb 1;4(2):285-292. Epub 2018 Nov 1.

Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.

Introduction: Patients on hemodialysis experience a heavy burden of symptoms that may be related to the low levels of physical activity reported in this population. We hypothesized that physical activity would be inversely related to symptom severity and that depression might mediate this association.

Methods: We designed a cross-sectional study of 48 patients receiving hemodialysis at 3 San Francisco dialysis clinics. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365400PMC
February 2019

Psychomotor Performance Decrements following a Successful Physical Activity Intervention for Insomnia.

Behav Sleep Med 2019 Feb 17:1-11. Epub 2019 Feb 17.

b School of Sport, Exercise and Health Sciences , Loughborough University , Loughborough , UK.

Objectives: Evidence supports the view that reductions in cognitive hyperarousal contribute substantially to improved sleep outcomes following cognitive and behavioral interventions for insomnia disorder. Assuming an inverted-u relationship between arousal and performance, a theoretical possibility, supported by limited empirical data, is that the same mediating processes could negatively impact aspects of psychomotor performance, reducing speed on tests of reaction time.

Participants: Sedentary participants (mean age = 59. Read More

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http://dx.doi.org/10.1080/15402002.2019.1578774DOI Listing
February 2019

Effect of diabetes on neurological adverse effects and chemotherapy induced peripheral neuropathy in advanced colorectal cancer patients treated with different FOLFOX regimens.

Pak J Pharm Sci 2019 Jan;32(1):125-130

Department Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

This retrospective study reports impact of diabetes on incidence rate of dose limiting symptoms of neurological toxicity and chemotherapy induced peripheral neuropathy (CIPN). Post-surgical colorectal cancer (CRC) patients with metastatic disease, treated with four different schedules of FOLFOX were included in this study. Neurological adverse effects were assessed by CTC v2. Read More

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January 2019
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Impact of acute sleep restriction on cerebral glucose metabolism during recovery non-rapid eye movement sleep among individuals with primary insomnia and good sleeper controls.

Sleep Med 2019 Jan 4;55:81-91. Epub 2019 Jan 4.

Department of Psychiatry, Center for Sleep and Circadian Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background: Restricting time in bed improves insomnia symptoms, but the neural mechanisms for this effect are unknown. Total and partial acute sleep restriction may be useful paradigms for elucidating these effects. We examined the impact of acute sleep restriction on cerebral glucose metabolism during non-rapid eye movement (NREM) sleep in individuals with primary insomnia (n = 17) and good sleep (n = 19). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.007DOI Listing
January 2019
1 Read

Sleep and sleep disorders in Franz Kafka's narrative works.

Sleep Med 2018 Dec 31;55:69-73. Epub 2018 Dec 31.

Neurology Service, Multidisciplinary Sleep Unit, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.

Objective: As Franz Kafka, one of the most important writers of the 20th century, suffered from severe chronic insomnia disorder and inadequate sleep hygiene that impaired his quality of life, we speculated that sleep disorders would be found in his narrative works.

Methods: We read Kafka's complete literary works looking for references to sleep and sleep disorders, excluding insomnia.

Results: In Kafka's works, sleeping well and for a long time was used as an allegory of having a pleasant life. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.015DOI Listing
December 2018
1 Read

Older ovarian cancer survivors report lower long-term health-related quality of life than younger survivors: A study from the population-based profiles registry.

Gynecol Oncol 2019 Feb 13. Epub 2019 Feb 13.

CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, the Netherlands; Netherlands Comprehensive Cancer Organisation, the Netherlands.

Objective: To assess long-term differences in health-related quality of life (HRQoL) of older ovarian cancer survivors compared to both an age-matched normative population and to younger survivors. In addition, the differential effect of chemotherapy on HRQoL between older and younger survivors was compared.

Methods: Ovarian cancer survivors (n = 348) diagnosed between 2000 and 2010, as registered by the Dutch population-based Eindhoven Cancer Registry, were invited to complete the EORTC QLQ-C30 HRQoL questionnaire in 2012. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.001DOI Listing
February 2019
1 Read

Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan).

Int J Pharm Pract 2019 Feb 15. Epub 2019 Feb 15.

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy.

Objectives: Our main aim was to investigate the short-term therapeutic effects, safety/tolerability and potential side effects of the cannabis galenical preparation (Bedrocan) in patients with a range of chronic conditions unresponsive to other treatments.

Methods: In this retrospective, 'compassionate use', observational, open-label study, 20 patients (age 18-80 years) who had appealed to our 'Second Opinion Medical Consulting Network' (Modena, Italy), were instructed to take sublingually the galenical oil twice a day for 3 months of treatment. The usual starting dose was low (0. Read More

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http://dx.doi.org/10.1111/ijpp.12514DOI Listing
February 2019
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Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019
1 Read

Prevalence and Correlates of Hypersomnolence Symptoms in US Teens.

J Am Acad Child Adolesc Psychiatry 2018 Oct 30. Epub 2018 Oct 30.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD.

Objective: Recent attention to pervasive sleep deficits in U.S. adolescents has focused on sleep patterns and insomnia, but there are limited data on the prevalence and correlates of hypersomnolence symptoms. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.435DOI Listing
October 2018
1 Read

Nonrestorative sleep scale: reliable and valid for the Chinese population.

Qual Life Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.

Purpose: To conduct a linguistic and psychometric evaluation of a Chinese version of the Nonrestorative Sleep Scale (NRSS).

Methods: The Chinese NRSS was created from a standard forward-backward translation and trialed on 10 Chinese adults. Telephone interviews were then conducted with 100 adults, who completed the Chinese NRSS, the Pittsburgh Sleep Quality Index (PSQI), the Athens Insomnia Scale (AIS), the Center for Epidemiological Studies Depression Scale (CES-D), and the Toronto Hospital Alertness Test (THAT). Read More

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http://dx.doi.org/10.1007/s11136-019-02134-8DOI Listing
February 2019
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2.486 Impact Factor

Auricular Plaster Therapy for Comorbid Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Evid Based Complement Alternat Med 2019 15;2019:7120169. Epub 2019 Jan 15.

School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Qiaokou District, Wuhan 430030, China.

Background: Although the effectiveness of auricular plaster therapy (APT) on primary insomnia has been systematically reviewed, no systematic review of studies has focused on the effect on comorbid insomnia.

Objective: To evaluate the efficacy and safety of APT for comorbid insomnia.

Methods: Fifteen databases were searched from inception to July 2018. Read More

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http://dx.doi.org/10.1155/2019/7120169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350581PMC
January 2019
1 Read

Wake-Up Sleepyhead: Unilateral Diencephalic Stroke Presenting with Excessive Sleepiness.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):145-147

Department of Neurology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.

Altered sleep architecture and stroke share a reciprocal relationship. More than half of the stroke patients display sleep abnormalities including hypersomnia, insomnia, parasomnia, periodic limb movements, or sleep-disordered breathing. Conversely, one of the major causes of severe organic hypersomnia is acute brainstem strokes, involving thalamic infarctions, which may be reversible over 6-12 months. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_258_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337964PMC
February 2019
1 Read

Insomnia symptoms and short sleep predict anxiety and worry in response to stress exposure: a prospective cohort study of medical interns.

Sleep Med 2018 Dec 14;55:40-47. Epub 2018 Dec 14.

Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

Study Objectives: While anxiety rates are alarmingly high in short sleeping insomniacs, the relationship between insomnia and anxiety symptoms has not been extensively studied, especially in comparison to the relationship between insomnia and depressive symptoms. Using residency training as a naturalistic stress exposure, we prospectively assessed the role of sleep disturbance and duration on anxiety-risk in response to stress.

Methods: Web-based survey data from 1336 first-year training physicians (interns) prior to and then quarterly across medical internship. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.001DOI Listing
December 2018
1 Read

Effectiveness and safety of fire-needle moxibustion on insomnia: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Feb;98(7):e14509

Baoan Hospital of Traditional Chinese Medicine in Shenzhen, Shenzhen.

Background: Fire-needle moxibustion (FNM) is an ancient method of external therapy that combines acupuncture with moxibustion, and has the property of high temperature resistance. Insomnia is a major public health problem and strongly associated with a high prevalence, impact on daily life, comorbidity with other disorders, and societal costs. The clinical practice demonstrates that FNM has a therapeutic effect on insomnia. Read More

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http://dx.doi.org/10.1097/MD.0000000000014509DOI Listing
February 2019
1 Read

Secondary outcomes of a behavioral sleep intervention: A randomized clinical trial.

Health Psychol 2019 Mar;38(3):196-205

James P. Wilmot Cancer Institute, Department of Surgery University of Rochester Medical Center.

Objective: Nearly 80% of cancer patients struggle with insomnia, which is associated with decreased heart rate variability (HRV) and quality of life (QOL). The aim of this secondary analysis was to evaluate the possible effects of Brief Behavioral Therapy for Cancer-Related Insomnia (BBT-CI), delivered during chemotherapy visits, on QOL and HRV in patients with breast cancer (BC).

Method: QOL and HRV data were obtained during a pilot clinical trial assessing the feasibility and effects of BBT-CI on insomnia. Read More

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http://dx.doi.org/10.1037/hea0000700DOI Listing
March 2019
1 Read

Paramedic and Emergency Medical Technician Reflections on the Ongoing Impact of the 9/11 Terrorist Attacks.

Prehosp Disaster Med 2019 Feb;34(1):56-61

3Harvard Humanitarian Initiative,Harvard University and Harvard T.C. Chan School of Public Health,Cambridge,MassachusettsUSA.

IntroductionIn the years following the September 11, 2001 terrorist attacks in New York City (New York USA), otherwise known as 9/11, first responders began experiencing a range of health and psychosocial impacts. Publications documenting these largely focus on firefighters. This research explores paramedic and emergency medical technician (EMT) reflections on the long-term impact of responding to the 9/11 terrorist attacks. Read More

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https://www.cambridge.org/core/product/identifier/S1049023X1
Publisher Site
http://dx.doi.org/10.1017/S1049023X18001255DOI Listing
February 2019
2 Reads

Executive Functions in Insomnia Disorder: A Systematic Review and Exploratory Meta-Analysis.

Front Psychol 2019 30;10:101. Epub 2019 Jan 30.

Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Executive functions (EFs) are involved in the control of basic psychological processes such as attention and memory and also contribute to emotion regulation. Research on the presence of EFs impairments in insomnia yielded inconsistent results. Therefore, we performed a systematic review of the literature on three EFs: inhibitory control, working memory, and cognitive flexibility in adults with insomnia in order to investigate the presence and magnitude of insomnia-related EFs impairments. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363670PMC
January 2019
5 Reads

Self-Regulation of Breathing as an Adjunctive Treatment of Insomnia.

Front Psychiatry 2018 29;9:780. Epub 2019 Jan 29.

Department of Pediatrics, Georgia Prevention Institute, Augusta University, Augusta, GA, United States.

Sleep is a quiescent behavioral state during which complex homeostatic functions essential to health and well-being occur. Insomnia is a very common psychiatric disorder leading to a myriad of detrimental effects including loss of concentration, memory, and performance as well as disease. Current pharmaceutical treatments can be expensive, impairing, unhealthy, and habit-forming. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361823PMC
January 2019
1 Read

[Insomnia and Hypersomnia among Children and Adolescents with Psychiatric Disorders].

Prax Kinderpsychol Kinderpsychiatr 2019 Feb;68(2):110-127

Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters Universitätsklinik Köln Robert-Koch-Str. 10 50931 Köln Kinder- und Jugendpsychiatrie | Kinder-Jugendpsychiatrie Uniklinik Köln.

Insomnia and Hypersomnia among Children and Adolescents with Psychiatric Disorders The common symptom of sleep disorders is non-restorative sleep, which results in daytime sleepiness. Therefore in clinical practice simultaneous complaints of "not enough" and "too much" sleep are very frequent. For the investigation and treatment of organic sleep disorders, available instruments, guidelines and specialised institutions (sleep centres or sleep laboratories) are more advanced than for non-organic sleep disorders. Read More

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https://www.vr-elibrary.de/doi/10.13109/prkk.2019.68.2.110
Publisher Site
http://dx.doi.org/10.13109/prkk.2019.68.2.110DOI Listing
February 2019
1 Read

Scale for retrospective assessment of immediate concussion symptoms.

Ment Illn 2018 Nov 20;10(2):7901. Epub 2018 Dec 20.

University of Western Ontario, London, Ontario, Canada.

The retrospective diagnosis of concussion is often missed by clinicians. We present a brief scale for retrospective assessment of the immediate concussion symptoms (ICS) to facilitate the diagnosis of patients without visible head injury or full loss of consciousness. We administered the scale to 90 survivors of car accidents (mean age 42. Read More

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http://dx.doi.org/10.4081/mi.2018.7901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342027PMC
November 2018
1 Read

The effect of nonbenzodiazepines sedative hypnotics on apnea-hypopnea index: A meta-analysis.

Ann Thorac Med 2019 Jan-Mar;14(1):49-55

Astria Health Center, Euclid, Grandview, Washington, USA.

Introduction: Nonbenzodiazepine (non-BZD) sedative hypnotics (NBSH) refer to non-BZD sedatives that act as BZD receptor agonists such as zolpidem, zaleplon, and eszopiclone. Today, there is a high prevalence of insomnia with or without concurrent obstructive sleep apnea (OSA). Our goal was to study how NBSH use impacts the baseline apnea-hypopnea index (AHI) in patients with or without OSA. Read More

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http://dx.doi.org/10.4103/atm.ATM_198_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341859PMC
February 2019
1 Read

Cognitive behaviour therapy for insomnia and depression: qualitative reflections from older adults who participated in a randomised controlled trial.

Aging Ment Health 2019 Feb 12:1-7. Epub 2019 Feb 12.

a School of Health and Life Sciences , Federation University Australia , Ballarat , Victoria , Australia.

Objectives: To explore the experiences of older adults who participated in a randomised controlled trial (RCT) that tested cognitive behaviour therapy for insomnia and depression.

Methods: Focus groups were conducted post treatment for older adults (M age = 75 years; 61% female) who participated in a RCT that tested two experiential interventions targeting comorbid insomnia and depression (cognitive behaviour therapy for insomnia, CBT-I; cognitive behaviour therapy for insomnia plus positive mood strategies, CBT-I+). Six semi-structured focus group interviews (N = 31) were analysed using a qualitative thematic analysis. Read More

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http://dx.doi.org/10.1080/13607863.2019.1571013DOI Listing
February 2019
1 Read

Sleep disorders and executive function in children and adolescents with chronic kidney disease.

Sleep Med 2018 Dec 14;55:33-39. Epub 2018 Dec 14.

1(st)Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.

Objective: The impact of sleep-related disorders in children and adolescents with chronic kidney disease on executive function performance has been scarcely studied. The aims of the present study were to assess the prevalence of sleep-related disorders in chronic kidney disease pediatric patients, and to examine possible correlations with measures of executive function.

Methods: We performed a case-control study including 51 children with chronic kidney disease stages 2-5, aged 5-18 years, and 51 healthy controls. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.020DOI Listing
December 2018
1 Read
3.154 Impact Factor

Insomnia symptoms predict both future hypertension and depression.

Prev Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. Electronic address:

The prevalence of hypertension and depression is high in older populations. Moreover, their comorbidity may significantly increase morbidity and mortality. However, the risk factors contributing to both health conditions are not well understood. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.001DOI Listing
February 2019
1 Read

Sleep disturbances are common in patients with autoimmune encephalitis.

J Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.

Objectives: Autoimmune encephalitis (AE) is increasingly recognized as an important cause of subacute cognitive decline, seizures, and encephalopathy, with an ever-broadening clinical phenotype. Sleep disturbances are reported in AE patients, including rapid eye movement sleep behavior disorder, hypersomnia, fragmented sleep, and sleep-disordered breathing; however, the prevalence of sleep disturbances and contributions to outcomes in AE patients remain unknown. There is a need to determine the prevalence of sleep disturbances in AE patients, and to clarify the relationship between specific autoantibodies and disruptions in sleep. Read More

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http://dx.doi.org/10.1007/s00415-019-09230-2DOI Listing
February 2019
1 Read

Frequent discussion of insomnia and weight gain with glucocorticoid therapy: An analysis of Twitter posts.

NPJ Digit Med 2018 Feb;1

Arthritis Research UK Centre for Epidemiology, University of Manchester.

In recent years, social media websites have been suggested as a novel, vast source of data which may be useful for deriving drug safety information. Despite this, there are few published reports of drug safety profiles derived in this way. The aims of this study were to detect and quantify glucocorticoid-related adverse events using a computerised system for automated detection of suspected adverse drug reactions (ADR) from narrative text in Twitter, and to compare the frequency of specific ADR mentions within Twitter to the frequency and patterns of spontaneous ADR reporting to a national drug regulatory body. Read More

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http://dx.doi.org/10.1038/s41746-017-0007-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364798PMC
February 2018
1 Read

The prevalence and clinical risk factors of insomnia in the Chinese elderly based on comprehensive geriatric assessment in Chongqing population.

Psychogeriatrics 2019 Feb 10. Epub 2019 Feb 10.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Insomnia is a major public health problem affecting older people. This study aimed to investigate the prevalence and clinical risk factors of insomnia in a representative sample of Chinese elderly (≥ 60 years) in Chongqing.

Methods: A cross-sectional study based on comprehensive geriatric assessment was conducted from January 2013 to February 2014. Read More

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http://dx.doi.org/10.1111/psyg.12402DOI Listing
February 2019
2 Reads
1.219 Impact Factor

[Life Quality and Its Related Factors of Patients with Multiple Myeloma during Maintenance Therapy].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):96-103

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.E-mail:

Objective: To evaluate the quality of life (QOL) on patients with multiple myeloma(MM) during maintenance therapy and to explore the related factors important for QOL.

Methods: The demography, clinical and laboratorial data of 66 MM patients during maintenance therapy were collected and explored by using a cross-sectional question naire(EORTC QLQ C30 V 3.0). Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.016DOI Listing
February 2019
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The Spectrum of Vestibular Migraine: Clinical Features, Triggers, and Examination Findings.

Headache 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA.

Objective: To assess the ictal symptoms, interictal symptoms, psychiatric comorbidities, and interictal neuro-otologic examination findings in vestibular migraine (VM).

Methods: Retrospective chart review of 491 patients seen from August 2014 until March 2018 at a tertiary neurology referral center for vestibular disorders to identify patients fulfilling the 2012 VM criteria.

Results: One hundred and thirty-one patients (105 women) were identified. Read More

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http://dx.doi.org/10.1111/head.13484DOI Listing
February 2019
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Insomnia Severity in Adults with Autism Spectrum Disorder is Associated with sensory Hyper-Reactivity and Social Skill Impairment.

J Autism Dev Disord 2019 Feb 9. Epub 2019 Feb 9.

Section Clinical Developmental Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

Insomnia is a common source of distress in adults with autism spectrum disorder (ASD). Two characteristics of ASD could be relevant to insomnia complaints by hampering the entrainment of a circadian sleep-wake rhythm. First, sensory hyper-reactivity could lead to bright light avoidance and thus affect photoperiodic input to the circadian system. Read More

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http://dx.doi.org/10.1007/s10803-019-03891-8DOI Listing
February 2019
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Effects of suvorexant on sleep apnea in patients with heart failure: A protocol of crossover pilot trial.

J Cardiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Suvorexant, an orexin receptor antagonist, is known as a safe and effective sleep medication. Many patients with heart failure (HF) have sleep-disordered breathing (SDB) and are short sleepers, and it is unknown whether suvorexant is effective in HF patients and can improve insomnia safely. The aim of this study is to examine the effect of suvorexant on SDB in patients with HF. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.12.021DOI Listing
February 2019
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Temporal Analysis of Chronic Musculoskeletal Pain and Sleep in Postmenopausal Women.

J Clin Sleep Med 2019 Feb 4. Epub 2019 Feb 4.

Study Objectives: To investigate the temporal association between chronic musculoskeletal pain (CMP) and sleep in women who are postmenopausal in a 10-day actigraphic study. This is a microlongitudinal study in which 52 participants were allocated to 4 groups women who are postmenopausal: control (CTRL, n = 10), chronic musculoskeletal pain (CMP, n = 12), insomnia (INS, n = 15) and chronic musculoskeletal pain+insomnia (CMP+INS, n = 15).

Methods: All volunteers underwent a clinical interview and completed questionnaires, used an actigraph, and kept sleep diaries for 10 consecutive days. Read More

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February 2019
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Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery. J-SUPPORT 1605 (ProD Study): study protocol for a randomized controlled trial.

Trials 2019 Feb 8;20(1):110. Epub 2019 Feb 8.

Department of Psycho-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan.

Background: Preoperative anxiety and postoperative delirium affect both short- and long-term prognoses in patients with cancer; therefore, these conditions require early prevention and treatment. However, no standard preventive or therapeutic methods have been established for them. Yokukansan, a Japanese herbal medicine for the treatment of insomnia and anxiety, causes relatively few adverse drug reactions and effectively improves the behavioral and psychological symptoms of dementia. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3202-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368807PMC
February 2019
3 Reads

Insomnia late in pregnancy is associated with perinatal anxiety: A longitudinal cohort study.

J Affect Disord 2019 Apr 28;248:155-165. Epub 2019 Jan 28.

HØKH, Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway; Department for Infant Mental Health, Regional Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway.

Background: Postpartum anxiety (PPA) affects a substantial number of women. Despite increasing recognition of PPA, few studies have focused on perinatal anxiety and potential PPA triggers. Here we aimed to estimate the prevalence of perinatal anxiety disorders, and to explore the association between insomnia during late pregnancy and anxiety before and after childbirth. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.027DOI Listing
April 2019
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Alerting the illusion of smoking improves quality of life in Chinese male cancer survivors.

Cancer Med 2019 Feb 8. Epub 2019 Feb 8.

Institute of Clinical Epidemiology, Key Laboratory of Public Health Safety, Ministry of Education, Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health, Fudan University, Shanghai, China.

Objective: To examine the association between smoking status and quality of life (QOL) among cancer survivors in China.

Methods: A cross-sectional study was performed in 2725 male cancer survivors who were members of Cancer Rehabilitation Club and completed the questionnaires in 2013. Using linear regression models adjusted for confounders, we measured the association between QOL and former smokers as well as current (occasional, <10 cigarettes/day, and ≥ 10 cigarettes/day) smokers compared with never smokers. Read More

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http://doi.wiley.com/10.1002/cam4.1999
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http://dx.doi.org/10.1002/cam4.1999DOI Listing
February 2019
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Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Second Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, China.

Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle-aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. Read More

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http://dx.doi.org/10.1111/jcmm.14170DOI Listing
February 2019
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The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease.

Front Pharmacol 2019 24;10. Epub 2019 Jan 24.

Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Gachon University, Incheon, South Korea.

Willdenow is a herb known for its therapeutic effects in insomnia, depression, disorientation, and memory impairment. In Alzheimer's disease (AD) animal model, there has been no report on the effects of memory and cognitive impairment. PSM-04, an extract from the root of Willdenow, was developed with improved bioabsorption. Read More

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http://dx.doi.org/10.3389/fphar.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353859PMC
January 2019
2 Reads

Body Silhouette Trajectories Over the Lifespan and Insomnia Symptoms: The Paris Prospective Study 3.

Sci Rep 2019 Feb 7;9(1):1581. Epub 2019 Feb 7.

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.

Insomnia symptoms are highly prevalent and associated with several adverse medical conditions, but only few determinants, including non-modifiable ones, have been highlighted. We investigated associations between body silhouette trajectories over the lifespan and insomnia symptoms in adulthood. From a community-based study, 7 496 men and women aged 50-75 years recalled their body silhouette at age 8, 15, 25, 35 and 45, and rated the frequency of insomnia symptoms on a standardized sleep questionnaire. Read More

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http://dx.doi.org/10.1038/s41598-018-38145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367427PMC
February 2019
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