31,045 results match your criteria Insomnia


Association between sleep disorder and atrial fibrillation: A nationwide population-based cohort study.

Sleep Med 2022 May 10;96:50-56. Epub 2022 May 10.

Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: Sleep disorder (SD), especially sleep apnea, and its effect on atrial fibrillation (AF) are gathering attention. However, other SDs may also play an essential role in AF. The aim of the study is to investigate the effects of other SDs on the risk of atrial fibrillation development. Read More

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Network analysis of depression, anxiety, insomnia and quality of life among Macau residents during the COVID-19 pandemic.

J Affect Disord 2022 May 17. Epub 2022 May 17.

Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao; Centre for Cognitive and Brain Sciences, University of Macau, Macao; Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao. Electronic address:

Background: Although the Coronavirus Disease 2019 (COVID-19) has greatly impacted individuals' mental health and quality of life, network analysis studies of associations between symptoms of common syndromes during the pandemic are lacking, particularly among Macau residents. This study investigated the network structure of insomnia, anxiety, and depression and explored their associations with quality of life in this population.

Method: This online survey was conducted in Macau between August 18 and November 9, 2020. Read More

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Changes in sleep following internet-delivered cognitive-behavioral therapy for insomnia in women treated for breast cancer: A 3-year follow-up assessment.

Sleep Med 2022 Apr 30;96:35-41. Epub 2022 Apr 30.

Unit for Psychooncology & Health Psychology, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

Background: Sleep disturbances are common in women treated for breast cancer. We have previously shown that internet-delivered cognitive-behavioral therapy for insomnia (e-CBT-I) is an efficacious, low-cost treatment approach. Furthermore, research has shown that e-CBT-I can result in sustained improvements at 12 months post-treatment. Read More

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Sleep disturbances and sleep disorders as risk factors for chronic postsurgical pain: A systematic review and meta-analysis.

Sleep Med Rev 2022 Apr 7;63:101630. Epub 2022 Apr 7.

IRCCS Istituto Delle Scienze Neurologiche di Bologna (ISNB), 40139, Bologna, Italy; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy. Electronic address:

This systematic review and meta-analysis aimed at evaluating the role of sleep disturbances and sleep disorders in influencing presence and intensity of chronic postsurgical pain (CPSP). We included cohort studies which enrolled adults, assessed sleep disturbances or disorders before surgery, measured pain intensity, presence of pain, or opioid use at least three months after surgery. Eighteen studies were included in a narrative synthesis and 12 in a meta-analysis. Read More

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Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App-Based Integrated Mental Health Care Model: Cohort Study.

J Med Internet Res 2022 May 20;24(5):e30907. Epub 2022 May 20.

Mood Disorders Psychopharmacology Unit, University Health Network, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Background: Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms and timely depressive disorder case identification and intervention may improve health outcomes and cost-effectiveness among affected individuals. China's public and academic communities have reached a consensus on the need to improve access to early screening, diagnosis, and treatment of depression. Read More

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seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism.

Pharm Biol 2022 Dec;60(1):810-824

College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.

Context: Lam. (Moringaceae) (MO) is an important food plant that has high nutritional and medical value. However, there is limited information on whether its seeds can improve sleep. Read More

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December 2022

The impact of Micro RNA-320a serum level on severity of symptoms and cerebral processing of pain in patients with fibromyalgia.

Pain Med 2022 May 19. Epub 2022 May 19.

Lecturer of Clinical Neurophysiology, Neuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.

Objectives: The aim of this work was to explore the expression of miR-320a level in fibromyalgia patients in comparison to healthy controls, and to clarify its impact on the severity of symptoms and the cerebral processing of pain assessed by middle latency somatosensory evoked potentials (SSEPs).

Design: Case-control study.

Setting: Rheumatology and Neurology outpatient clinics. Read More

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Probiotic Properties and Optimization of Gamma-aminobutyric Acid Production by FBT215.

J Microbiol Biotechnol 2022 May 13;32(6):1-10. Epub 2022 May 13.

Department of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea.

Gamma-aminobutyric acid (GABA) improves various physiological illnesses, including diabetes, hypertension, depression, memory lapse, and insomnia in humans. Therefore, interest in the commercial production of GABA is steadily increasing. Lactic acid bacteria (LAB) have widely been reported as a GABA producer and are safe for human consumption. Read More

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Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study.

Front Neurol 2022 2;13:765321. Epub 2022 May 2.

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.

Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry. We selected five neurodegenerative disorders, namely, age-related macular degeneration (AMD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Parkinson's disease (PD). Sleep duration (SD), short sleep (SS), long sleep (LS), chronotype (CHR), morning person (MP), insomnia (INS), and multisite chronic pain (MCP) were considered as exposures. Read More

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The Involvement of Melatonin and Tasimelteon against Alzheimer's Disease.

Curr Drug Saf 2022 May 17. Epub 2022 May 17.

Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India.

Background: Alzheimer's disease is an age-dependent neurodegenerative disease with a progressive cognition and memory loss, insomnia and other abnormal behavioral changes. Amongst various hypothesis for the AD pathophysiology, the occupational stress-induced Alzheimer's has recently caught up an escalation in AD cases.

Objective: Studies pertaining to the same suggests that stress leads to insomnia or sleep disruption, which further leads to neuroinflammation cum oxidative stress, both of which are major harbingers towards AD. Read More

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Discrepancy between subjective and objective sleep duration among dementia caregivers and non-caregivers.

J Clin Sleep Med 2022 May 19. Epub 2022 May 19.

Department of Psychiatry, University of California San Diego, California.

Study Objectives: Poor sleep, including short sleep duration, is common among caregivers of persons with dementia. However, it is unclear whether poor sleep is consistent across both self-reported and objective measures of sleep in caregivers. This study aimed to test the role of caregiving status (caregivers vs. Read More

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Attitudes, beliefs and knowledge about medical cannabis among nurses and midwives in Cyprus: a cross-sectional descriptive correlational study.

BMC Nurs 2022 May 19;21(1):120. Epub 2022 May 19.

Associate Professor, Department of Nursing, School of Health Sciences, Faculty of Health Sciences, Mental Health Studies & Research Cyprus University of Technology Chair Cyprus University of Technology Vragadinou Street, Limassol, Cyprus.

Background: There is a lack of evidence on healthcare professionals' attitudes, knowledge, and beliefs about medical cannabis in Cyprus and across the world. Therefore, the present study aimed to explore the attitudes, beliefs, and knowledge about MC use among nurses and midwives in Cyprus. Special focus was given to differences across gender, age, religion, marital status, and years of work experience. Read More

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A Systematic Review of the Impact of Select Mindfulness Interventions on Psychological Outcomes among Older Adults with Chronic Health Conditions.

Clin Gerontol 2022 May 18:1-13. Epub 2022 May 18.

School of Social Work, University of Michigan, Ann Arbor, Michigan, USA.

Objectives: Chronic medical conditions can increase the likelihood of experiencing psychological distress and mental health problems among older adults. Mindfulness interventions (MIs) are evidence-based treatment approaches that can improve psychological outcomes. This systematic literature review examines MI studies that focused on older adults (≥60 years old) with chronic health conditions. Read More

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Dose adjustments of Elexacaftor/Tezacaftor/Ivacaftor in response to mental health side effects in adults with cystic fibrosis.

J Cyst Fibros 2022 May 15. Epub 2022 May 15.

Regional Adult CF Centre, St James's University Hospital, Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom; Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom. Electronic address:

Introduction: Deterioration in mental health has been reported in a minority of individuals with cystic fibrosis starting elexacafor/tezacaftor/ivacaftor (ELX/TEZ/IVA). We report our experience of using sweat chloride and markers of clinical stability to titrate dose reduction with the aim of minimising adverse events and maintaining clinical stability.

Method: Adults (n = 266) prescribed ELX/TEZ/IVA, were included. Read More

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Relationship between perceived stress and depression in Chinese front-line medical staff during COVID-19: A conditional process model.

J Affect Disord 2022 May 15;311:40-46. Epub 2022 May 15.

Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen, China. Electronic address:

Background: Sustained stress during COVID-19 may be associated with depression in front-line medical staff, which would expose them to severe threats. This study aimed to examine whether the relationship between perceived stress and depression is mediated by insomnia, and whether this mediation is moderated by resilience.

Methods: For front-line medical staff, this study used online questionnaire to evaluate their perceived stress, depression, insomnia and resilience. Read More

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Brazilian descriptive study of 104 consecutive real-world migraine patients treated with monoclonal antibodies.

Postgrad Med 2022 May 18. Epub 2022 May 18.

Headache Center of Rio, Brazil.

Background: Migraine is a highly disabling and prevalent neurological disorder. A peptide, calcitonin gene-related peptide, was identified as involved in migraine pathophysiology and monoclonal anti-CGRP antibodies have been developed.

Aim: To describe the clinical characteristics and therapeutic response of migraine patients treated with monoclonal antibodies. Read More

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"With insomnia, nothing is real": The Role of Gender and Cognitive Restructuring in Stress Induced Insomnia and Burnout.

Psychiatr Hung 2022 ;37(2):166-174

University of Pécs, Faculty of Humanities and Social Sciences, Institute of Psychology, Pecs, Hungary, E-mail:

Introduction: The aim of our study is to provide a theoretical and practical framework to the better under standing of insomnia and its relationship with perceived stress, burnout, cognitive restructuring and gender. The prior findings supported the integration of these constructs into a comprehensive model that helps us identify their complex system.

Methods: In our cross-sectional self-report study, 216 responders participated. Read More

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Effects of mindfulness-based intervention programs on sleep among people with common mental disorders: A systematic review and meta-analysis.

World J Psychiatry 2022 Apr 19;12(4):636-650. Epub 2022 Apr 19.

School of Behavioral and Applied Science, Azusa Pacific University, Azusa, CA 91702, United States.

Background: Sleep problems are particularly prevalent in people with depression or anxiety disorder. Although mindfulness has been suggested as an important component in alleviating insomnia, no comprehensive review and meta-analysis has been conducted to evaluate the effects of different mindfulness-based intervention (MBI) programs on sleep among people with depression or anxiety disorder.

Aim: To compare the effects of different MBI programs on sleep among people with depression or anxiety disorder. Read More

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Insomnia disorders are associated with increased cardiometabolic disturbances and death risks from cardiovascular diseases in psychiatric patients treated with weight-gain-inducing psychotropic drugs: results from a Swiss cohort.

BMC Psychiatry 2022 May 17;22(1):342. Epub 2022 May 17.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, University of Lausanne, 1008 Prilly, Prilly, Switzerland.

Study Objectives: Insomnia disorders as well as cardiometabolic disorders are highly prevalent in the psychiatric population compared to the general population. We aimed to investigate their association and evolution over time in a Swiss psychiatric cohort.

Methods: Data for 2861 patients (8954 observations) were obtained from two prospective cohorts (PsyMetab and PsyClin) with metabolic parameters monitored routinely during psychotropic treatment. Read More

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Under-graduate nursing students working during the first outbreak of the COVID-19 pandemic: A qualitative study of psychosocial effects and coping strategies.

Int J Nurs Pract 2022 May 17:e13065. Epub 2022 May 17.

Department of Nursing, Red Cross College of Nursing, Universidad Autónoma de Madrid, Madrid, Spain.

Background: The first wave of the COVID-19 pandemic caused a shortage of health care staff, forcing the hiring of senior nursing students.

Aims: To describe the psychosocial impact and coping strategies used by nursing students during the first outbreak of the COVID-19 pandemic and to understand the coping strategies they employed.

Method: A qualitative exploratory study was conducted, based on Sandelowski's proposal. Read More

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Effectiveness of cognitive behavioral therapy in improving functional health in cancer survivors: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2022 May 14;175:103709. Epub 2022 May 14.

University of Michigan School of Social Work, United States; Adolescent and Young Adult Oncology Program, University of Michigan Health, United States.

Background: Cancer survivors suffer from health deficits caused by their disease and treatment. This study conducted a systematic review and meta-analysis on how, and to what extent, cognitive-behavioral therapy (CBT) impacts functional health outcomes in cancer survivors.

Methods: We searched 7 electronic databases, 91 published review articles, and 4 professional websites for eligible randomized and non-randomized controlled trials focusing on cancer survivors. Read More

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Depressive Symptoms, Subjective Cognitive Decline, and Subjective Sleep Quality Are Associated with Slips and Falls: Data from the Community Health Survey in Korean Adults.

Gerontology 2022 27;68(5):518-528. Epub 2021 Dec 27.

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea.

Background: Identifying the risk factors for falls among the elderly population is arguably one of the most imperative public health issues in the current aging society.

Objectives: This study aimed to determine the associations between depressive symptoms, subjective cognitive decline (SCD), and poor subjective sleep quality and the risk of slips/falls in a Korean older population.

Methods: This cross-sectional study involved 228,340 elderly individuals living in Korea. Read More

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Psychological responses of medical staff during COVID-19 and the adjustment effect of brief mindfulness meditation.

Complement Ther Clin Pract 2022 May 6;48:101600. Epub 2022 May 6.

Department of Stress Medicine, Faculty of Psychology and Mental Health, Naval Medical University, Shanghai, 200433, China. Electronic address:

Background: COVID-19 has posed an unprecedented threat to public health and remains a critical challenge for medical staff, especially those who have been fighting against the virus in Wuhan, China. Limited data have been reported regarding the psychological status of these medical staff members. Therefore, we conducted this study to explore the mental health status of medical staff and the efficacy of brief mindfulness meditation (BMM) in improving their mental health. Read More

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Mechanisms of Cognitive Behavioral Therapy and Light Therapy for Cancer-Related Insomnia: A Randomized Clinical Trial during Chemotherapy for Breast Cancer.

Behav Sleep Med 2022 May 17:1-15. Epub 2022 May 17.

School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.

Study Objectives: This study aimed to investigate the mechanisms of a combined brief cognitive behavioral plus bright light therapy (CBT-I+Light) in women receiving chemotherapy.

Methods: Women (N = 101) were randomly assigned to CBT-I+Light or treatment as usual plus relaxation audios (TAU+). Participants completed sleep diaries and wore an actigraph during the 6-week intervention period. Read More

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Assessment of Suvorexant and Eszopiclone as Alternatives to Benzodiazepines for Treating Insomnia in Patients With Major Depressive Disorder.

Clin Neuropharmacol 2022 May-Jun 01;45(3):52-60. Epub 2022 Apr 14.

Departments of Clinical Pharmacology and Therapeutics.

Objectives: We investigated the utility of switching from benzodiazepines to suvorexant or eszopiclone to manage benzodiazepine-unresponsive insomnia in patients with major depressive disorder (MDD) in a randomized, open-label study.

Methods: Patients with MDD who have insomnia symptoms (a score of >7 on the Insomnia Severity Index Japanese version [ISI-J]), who had received benzodiazepine treatment for more than 2 weeks (n = 18) were randomized to 4 weeks of suvorexant (20 or 15 mg/d) or eszopiclone (3 or 2 mg/d) treatment. The primary endpoint was an improvement in insomnia severity from baseline assessed by the ISI-J score at 2 and 4 weeks after switching from benzodiazepines. Read More

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An insight through various models being used for Assessment of depression and its management at primary level in current scenario.

CNS Neurol Disord Drug Targets 2022 May 16. Epub 2022 May 16.

Department of Pharmacy, Shri Ram Murti Smarak College of Engineering & Technology, Bareilly (243202), India.

Aim: The main aim of present study to assess the depression and various neurotransmitters involved in it with their evaluating models.

Background: Depression is a common ailment that can be recurrent or even become chronic. According to the National Service Framework for Mental Health (released in 1999 by the Department of Health), people with depression should continue to be treated primarily in primary care settings. Read More

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Presence of a psychiatric patient at home and work fatigue in family caregivers: The moderating effect of spirituality.

Perspect Psychiatr Care 2022 May 16. Epub 2022 May 16.

Department of Social and Education Sciences, School of Arts and Sciences, Lebanese American University, Jbeil, Lebanon.

Objectives: To assess the association between the mental health of caregivers having a psychiatric patient at home and work fatigue, and if this association is moderated by spirituality.

Methods: This case-control study enrolled 600 caregivers (July-September 2019).

Results: Stress, anxiety, insomnia and the presence of a psychiatric patient at home were associated with higher levels of physical, mental, and emotional work fatigue. Read More

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