22,456 results match your criteria Insomnia
Sleep Med Rev 2018 Nov 16;43:96-105. Epub 2018 Nov 16.
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine University of Freiburg, Germany.
Previous research has identified insomnia as a predictor for the onset of depression. The aim of this meta-analysis is to investigate whether insomnia also predicts the onset of other mental disorders. Longitudinal studies were eligible for inclusion if they investigated insomnia at baseline (including nighttime- and daytime-symptoms) as a predictor of the later onset of psychopathology within a follow-up time-frame of at least 12 mo. Read More
CNS Drugs 2018 Dec 10. Epub 2018 Dec 10.
Biogen, Cambridge, MA, USA.
Background: Walking impairment is a hallmark of multiple sclerosis (MS). It affects > 90% of individuals over time, reducing independence and negatively impacting health-related quality of life, productivity, and daily activities. Walking impairment is consistently reported as one of the most distressing impairments by individuals with MS. Read More
Sleep 2018 Dec 11. Epub 2018 Dec 11.
AfaSci Research Laboratories, Redwood City, California, USA.
Study Objectives: A major challenge in treating insomnia is to find effective medicines with fewer side effects. Activation of G-protein-gated inward rectifying K+ channels (GIRKs) by GABAB agonists baclofen or γ-hydroxybutyric acid (GHB) promotes non-rapid eye movement (NREM) sleep and consolidates sleep. However, baclofen has poor brain penetration, GHB possesses abuse liability, and in rodents both drugs cause spike-wave discharges (SWDs), an absence seizure activity. Read More
Front Neurosci 2018 23;12:860. Epub 2018 Nov 23.
Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Primary insomnia (PI) is the second most common mental disorder. However, the topologic alterations in structural brain connectome in patients with PI remain largely unknown. A total of 44 PI patients and 46 age-, gender-, and education level matched healthy control (HC) participants were recruited in this study. Read More
J Med Internet Res 2018 Dec 7;20(12):e10124. Epub 2018 Dec 7.
Sleep and Behavioral Neuroscience Center, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Background: Although evidence-based cognitive behavioral sleep treatments have been shown to be safe and effective, these treatments have limited scalability. Mobile health tools can address this scalability challenge. iREST, or interactive Resilience Enhancing Sleep Tactics, is a mobile health platform designed to provide a just-in-time adaptive intervention (JITAI) in the assessment, monitoring, and delivery of evidence-based sleep recommendations in a scalable and personalized manner. Read More
Sleep Med 2018 Oct 25;54:101-112. Epub 2018 Oct 25.
Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Introduction: Clinical research and studies using animal models have revealed a complex and relatively under-explored interaction between prenatal alcohol exposure (PAE) and alterations in sleep-wake behaviors.
Objectives: To utilize a structured naturalistic observation-based methodology, consisting of descriptive elements, to provide insight into possible links between altered sleep and disruptive daytime presentations in children and adolescents with fetal alcohol spectrum disorder (FASD). To apply a similar structured behavioral observation protocol in a PAE animal model to compare outcomes from the experimental and clinical studies utilizing naturalistic observational methodology. Read More
Int Immunopharmacol 2018 Dec 6;67:13-21. Epub 2018 Dec 6.
Provincial Key Lab. of the Conservation and Exploitation Research of Biological Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui 241000, China. Electronic address:
Helicid (4-formylphenyl-β-D-allopyranoside) is a bioactive constituent of Helicid nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat headache, insomnia, and depression. However, the underlying mechanisms of these effects are unclear. We have now investigated the effect of helicid on depression-related behaviors in rats exposed to chronic unpredictable mild stress (CUMS) and have also explored possible underlying mechanisms that involve neurotrophin expression. Read More
Sleep Med 2018 Oct 29;54:86-93. Epub 2018 Oct 29.
Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Introduction: Both guided online and individual face-to-face cognitive behavioral therapy for insomnia (CBT-I) are effective in improving insomnia symptoms and sleep efficiency. Little is known about the underlying mechanisms generating this effect. The present study tests the assumption that pre-sleep arousal, sleep-related worry and dysfunctional beliefs about sleep are mediators in the effect of cognitive behavioral treatment for insomnia. Read More
Sleep Med 2018 Oct 25;54:53-61. Epub 2018 Oct 25.
Brain and Mind Centre, School of Medicine and Health, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia. Electronic address:
Objectives: We evaluated whether insomnia symptoms and short or long sleep duration, alone or in combination, are robustly associated with subsequent trajectory of mental health symptoms.
Methods: Participants were 2598 individuals (15 to 94 years of age) with elevated mental health symptoms at baseline (2013-14). Associations of baseline insomnia symptoms and sleep duration with two-year trajectory of mental health were estimated and adjusted for multiple potential confounders. Read More
Sleep Med Rev 2018 Nov 11;43:71-83. Epub 2018 Nov 11.
Adelaide Institute for Sleep Health, A Flinders Centre of Research Excellence, Flinders University of South Australia, Australia; School of Psychology, Flinders University of South Australia, Australia.
The purpose of this review was to evaluate the strength of evidence for a relationship between risk of mortality and frequent and ongoing insomnia using a meta-analytic strategy. Seventeen studies, including a total of 36,938,981 individuals followed up for a mean of 11.6 y, reporting the investigation of the association between mortality and frequent (≥3 nights/wk), ongoing (≥1 mo) insomnia were identified. Read More
J Pediatr (Rio J) 2018 Dec 7. Epub 2018 Dec 7.
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola de Medicina, Departamento de Neurociências, Porto Alegre, RS, Brazil; Instituto do Cérebro do Rio Grande do Sul (InsCer), Porto Alegre, RS, Brazil. Electronic address:
Objectives: To describe the association between sleep duration and weight-height development in children and adolescents.
Source Of Data: A non-systematic search in the MEDLINE database was performed using the terms anthropometry, body composition, overweight, obesity, body mass index, growth, length, short stature, sleep, children, and infants and adolescents, limited to the last 5 years. The references cited in the revised articles were also reviewed, when relevant. Read More
PLoS One 2018 6;13(12):e0207392. Epub 2018 Dec 6.
Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Background: Insomnia is one of the main symptoms of sleep disorders. Previous studies have suggested that alcohol intake is associated with several adverse health outcomes. The association between alcohol consumption and insomnia has been addressed in several studies with different results. Read More
Sleep 2018 Dec 5. Epub 2018 Dec 5.
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.
Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.
Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More
Sleep 2018 Dec 5. Epub 2018 Dec 5.
CRUK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow.
Study Objectives: Insomnia in cancer patients is prevalent, persistent and confers risk for physical and psychological disorder. We must better understand how insomnia develops in cancer patients and explore the main contributors to its chronicity so that insomnia management protocols can be integrated more effectively within cancer care. This study monitors the etiology of insomnia in breast cancer patients and identifies risk factors for its persistence. Read More
Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.
Department of Pediatrics, USF Health South Tampa Center for Advanced Healthcare, Tampa, FL 33606, USA.
Clonazepam undergoes nitroreduction to 7-amino-clonazepam via CYP3A4/5, followed by acetylation to 7-acetamido-clonazepam via N-acetyltransferase-2 (NAT2) enzyme. While no pharmacological activity is attributed to the metabolites of clonazepam, 7-amino-clonazepam has some affinity for the benzodiazepine receptor as a partial agonist for the gamma aminobutyric acid-A receptor and can compete with clonazepam. Interindividual variability in the incidence of adverse events in patients may, in part, be attributable to differences in clonazepam metabolism. Read More
J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.
J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.
Study Objectives: To investigate the association between non-apnea sleep disorders (NSD) and subsequent benign paroxysmal positional vertigo (BPPV) risk.
Methods: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database from 2000 to 2013. We established an NSD group (n = 24,624) and an age-, sex- and index year-matched comparison group (n = 98,496). Read More
J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.
Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample.
Methods: As part of the EPISONO cohort (São Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. Read More
J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.
Study Objectives: We investigated the interaction between objective sleep disturbance and obesity, sedentary lifestyle, and lung dysfunction and whether it is negatively associated with cardiorespiratory fitness.
Methods: In this community cohort study of 521 men (age 46.6 ± 7. Read More
Sleep Med 2018 Oct 4;53:115-123. Epub 2018 Oct 4.
Erasme Hospital, Department of Psychiatry and Sleep Laboratory, Université Libre de Bruxelles, ULB, Brussels, Belgium.
Introduction: Given conflicting data in the literature, the aim of this study was to examine the risk of high blood pressure (HBP) associated with sleep alterations, measured during polysomnography, and long-term use of benzodiazepine receptor agonists in a large sample of individuals with insomnia.
Methods: Demographic and polysomnographic data from 1272 individuals with insomnia recruited from the research database of the sleep laboratory of Erasme Hospital were analyzed. HBP status was defined by the presence of one of the following: self-report at interview of either a physician's diagnosis or taking antihypertensive medication; or an average systolic blood pressure ≥140 mm Hg or an average diastolic blood pressure ≥90 mm Hg at the medical examination. Read More
J Thorac Oncol 2018 Nov 30. Epub 2018 Nov 30.
University Medical Center, Johannes Gutenberg University Mainz, Germany; University Cancer Center Mainz, Germany.
Introduction: The objective was to assess quality of life (QoL) in lung cancer survivors, compare it to the general population, and identify factors associated with global QoL, physical functioning, emotional functioning, fatigue, pain, and dyspnea.
Methods: Data from non-small-cell lung cancer (NSCLC) patients who had survived ≥1 year after diagnosis were collected cross-sectionally in a multicenter study. QoL was assessed with the EORTC QLQ-C30 and the lung cancer module QLQ-LC13 across different clinical subgroups and compared to age- and gender-standardized general population reference values. Read More
Nurs Forum 2018 Dec 3. Epub 2018 Dec 3.
Department of Mental Health, Gerontology and Community Nursing, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia.
Objectives: Sleep deprivation can cause serious physical and mental problems. Although sleep deprivation among adolescents is not a new phenomenon, this problem has recently gained more attention due to the frequent use of smartphones. This study aimed to explain the correlations among family support, academic stress, social network site (SNS) use, and insomnia in adolescents. Read More
Crit Care Nurs Q 2019 Jan/Mar;42(1):75-80
Princess Aisha Bint Al-Hussein College of Nursing & Health Sciences, Al-Hussein Bin Talal University, Maan, Jordan (Dr Bani Younis); Faculty of Nursing, University of Jordan, Amman, Jordan (Dr Hayajneh); and Philadelphia University, Amman, Jordan (Dr Batiha).
The general goal of this review is to summarize, clarify, and evaluate what is known about patients' sleep in the intensive care units (ICUs) in terms of sleep measurement and management. In addition, this review focuses on the gap in knowledge in this field. A review of online databases for relevant articles in the period between 2000 and 2017 was conducted. Read More
Neurol Sci 2018 Dec 1. Epub 2018 Dec 1.
Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.
Objectives: This study investigated to identify the clinical significance of allodynia compared with other sensory hypersensitivities (SH) in migraine patients.
Methods: New patients with migraine were recruited from a headache clinic, and we collected data regarding their clinical characteristics and identified SH including photophobia, phonophobia, osmophobia, and allodynia. The patients completed the 12-item Allodynia Symptom Checklist, Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS), and Migraine-Specific Quality of Life Questionnaire Version 2. Read More
Front Psychiatry 2018 16;9:590. Epub 2018 Nov 16.
The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
The psychological and psychiatric literature has seldom appreciated the clinical fact that fears of ghosts and kindred supernatural worries may be a cause of intense discomfort, poor sleep, and socio-occupational impairment. In the present article, this claim is illustrated by the clinical features of six patients who developed intense anxiety when they had to sleep alone at night. The fears were first noticed in childhood and persisted into adolescence and adulthood. Read More
Biol Pharm Bull 2018 ;41(12):1778-1790
Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University.
Melatonin has been suggested to play important roles in lipid metabolism as well as circadian rhythm; however, very few studies explored the effects of ramelteon, a selective melatonin receptor agonist, on serum lipid profiles. In this study effects of ramelteon on serum lipid profiles were explored, comparing to those of other sleep-promoting drugs including benzodiazepines and non-benzodiazepines, in patients with insomnia. We retrospectively reviewed medical charts of outpatients who were treated with ramelteon (8 mg/d) or other sleep-promoting drugs for no less than 8 weeks during the period between October 1st, 2011 and September 30th, 2014, and compared the changes in serum lipid profiles between the two groups. Read More
Am J Geriatr Psychiatry 2018 Nov 2. Epub 2018 Nov 2.
Department of Neurology (SET), Columbia University, New York.
Objective: Insomnia is an important clinical problem affecting the elderly. We examined trends in insomnia diagnosis and treatment among Medicare beneficiaries over an eight-year period.
Methods: This was a time-series analysis of Medicare administrative data for years 2006-2013. Read More
Sleep 2018 Dec 4. Epub 2018 Dec 4.
Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Study Objectives: Patients with chronic obstructive pulmonary disease (COPD) have impaired pulmonary gas exchange near sea level. The purpose of the current study was to investigate whether exposure to hypobaric hypoxia during a stay at altitude affects nocturnal oxygen saturation, breathing pattern, and sleep in patients with moderate to severe COPD.
Methods: Thirty-two patients with COPD, median age 67 years, FEV1 59% predicted, PaO2 68 mmHg, living below 800 m, underwent polysomnography and questionnaire evaluations in Zurich (490 m), and in Swiss Alpine villages at 1650 and 2590 m, for two nights each, in random order. Read More
Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180004. Epub 2018 Nov 29.
Faculdade de Medicina, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brasil.
Aim: To analyze the consumption of tobacco, alcohol and illicit drugs among schoolchildren according to demographic factors, family context and mental health.
Methods: We used data from the National School-based Health Survey 2015 and included in the sample 102,301 schoolchildren in the 9th grade. We estimated the prevalence of tobacco and alcohol use in the last 30 days and drug experimentation according to demographic, mental health and family context variables. Read More
Clin Orthop Relat Res 2018 Nov 13. Epub 2018 Nov 13.
A. Y. L. Wong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China D. Samartzis, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA P. W. H. Cheung, J. P. Y. Cheung, Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.
Background: Adolescent idiopathic scoliosis (AIS) is the most common spine deformity in adolescent patients. Although structural deformity may affect spinal biomechanics of patients with AIS, little is known regarding various period prevalence proportions of back pain and chronic back pain and factors associated with back pain in such patients.
Questions/purposes: (1) What are the period prevalence rates of back pain among teenagers with AIS? (2) Is back pain in patients with AIS associated with curve severity?
Methods: A total of 987 patients with AIS who were treated without surgery were recruited from a single center's scoliosis clinic. Read More
Psychiatr Genet 2018 Dec 3. Epub 2018 Dec 3.
Department of Psychiatry, Center for Circadian Biology, VA San Diego Healthcare System, University of California San Diego, San Diego, California, USA.
Circadian rhythm abnormalities have been recognized as a central feature of bipolar disorder (BD) but a coherent biological explanation for them remains lacking. Using genetic mutation of 'clock genes', robust animal models of mania and depression have been developed that elucidate key aspects of circadian rhythms and the circadian clock-mood connection. However, translation of this knowledge into humans remains incomplete. Read More
Turk Kardiyol Dern Ars 2018 12;46(8):692-701
Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
Objective: This cross-sectional, descriptive study evaluated the relationship between the caregiver burden and the psychosocial adjustment of caregivers to cardiac failure patients.
Methods: Between November 18, 2015 and March 1, 2016, a preliminary information form, the Caregiver Burden Scale, and the Psychosocial Adjustment to Illness Scale were used to assess the caregivers of 200 patients being treated in the cardiology service of a university hospital.
Results: Among the caregivers, 75% were primary or secondary school graduates, 36% were housewives, and 43% were the patients' spouse. Read More
Psychol Health 2018 Dec 5:1-20. Epub 2018 Dec 5.
a School of Psychology , Université Laval , Québec , Canada.
Objectives: This study examined the cross-sectional and prospective relationships between subjective (cognitive reappraisal, expressive suppression and experiential avoidance) and objective (high-frequency heart rate variability [HF-HRV]) measures of emotion regulation (ER) and a set of psychological symptoms (anxiety, depression, fear of cancer recurrence [FCR], insomnia, fatigue, pain, and cognitive impairments) among women receiving radiation therapy for non-metastatic breast cancer.
Design: Eighty-one participants completed a battery of self-report scales within 10 days before the start of radiotherapy (T1) and within 10 days after its end (T2; approximately 6 weeks after T1). HF-HRV at rest was measured at T1. Read More
Brain Behav 2018 Dec 4:e01172. Epub 2018 Dec 4.
Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Introduction: Prior sleep behavior has been shown to correlate with waking resting-state functional connectivity (FC) in the default mode network (DMN). However, the impact of sleep history on FC during sleep has not been investigated. The aim of this study was to establish whether there is an association between intersubject variability in habitual sleep behaviors and the strength of FC within the regions of the DMN during non-rapid eye movement (NREM) sleep. Read More
J Sleep Res 2018 Dec 4:e12790. Epub 2018 Dec 4.
Department of Psychosocial Science, Faculty of Psychology, University of Bergen, Bergen, Norway.
The aim of this study was to describe sleep patterns and rate of insomnia according to diagnostic criteria in college and university students, as well as to examine potential changes in sleep problems from 2010 to 2018. Data stemmed from a national student health survey from 2018 for higher education in Norway (the SHoT study), which invited all 162,512 fulltime students in Norway. A total of 50,054 students (69. Read More
BMC Cancer 2018 Dec 4;18(1):1203. Epub 2018 Dec 4.
Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, 450 Brookline Avenue, LW 518, Boston, MA, 02215, USA.
Background: Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. Read More
J Sport Exerc Psychol 2018 Dec 5:1-13. Epub 2018 Dec 5.
1 University of Basel.
Few studies have examined the association between sleep and burnout symptoms in elite athletes. We recruited 257 young elite athletes (M = 16.8 years) from Swiss Olympic partner schools. Read More
Epilepsy Behav 2018 Dec 1;90:61-65. Epub 2018 Dec 1.
Department of Neurology, Gil Medical Center, Gachon Medical School, Incheon, Republic of Korea.
Objectives: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE).
Methods: A total of 147 AWE who had been treated for >1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Read More
Int Arch Occup Environ Health 2018 Dec 3. Epub 2018 Dec 3.
Finnish Institute of Occupational Health, Työterveyslaitos, PO Box 40, 00032, Helsinki, Finland.
Purpose: Although shift work disorder (SWD) affects a major part of the shift working population, little is known about its manifestation in real life. This observational field study aimed to provide a detailed picture of sleep and alertness among shift workers with a questionnaire-based SWD, by comparing them to shift workers without SWD during work shifts and free time.
Methods: SWD was determined by a questionnaire. Read More
Brain Imaging Behav 2018 Dec 4. Epub 2018 Dec 4.
Department of Neurology, Chengdu Second People's Hospital, No. 10 Qingyunnan Road, Chengdu, 610017, Sichuan, China.
Studies have explored brain structural abnormalities in patients with primary insomnia (PI). However, most of them are based on volumetric measures, in a specific region of interest, and have small sample sizes. Here, we investigated changes in cortical morphology (thickness and volume) in PI using an advanced surface-based morphometric method. Read More
Saudi Pharm J 2018 Dec 20;26(8):1204-1207. Epub 2018 Jul 20.
University of Arizona College of Pharmacy, USA.
Background: Hospitalization can contribute to insomnia in many patients and is usually treated symptomatically. However, sedative/hypnotic misuse is associated with complications in this population, especially in the elderly. Such complications include dizziness, falls and over-sedation. Read More
Palliat Support Care 2018 Dec 4:1-5. Epub 2018 Dec 4.
Palliative Care and Rehabilitation Medicine,The University of Texas MD Anderson Cancer Center,Houston,TX.
IntroductionCancer-related drowsiness (CRD) is a distressing symptom in advanced cancer patients (ACP). The aim of this study was to determine the frequency and factors associated with severity of CRD. We also evaluated the screening performance of Edmonton Symptom Assessment Scale-drowsiness (ESAS-D) item against the Epworth Sedation Scale (ESS). Read More
J Psychiatr Res 2018 Nov 22;109:59-67. Epub 2018 Nov 22.
School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Objective: To evaluate the efficacy of using electroacupuncture as an adjunct treatment in enhancing the benzodiazepine cessation rate in long-term benzodiazepine users.
Methods: This was a randomized, assessor- and subject-blinded, controlled trial. One hundred and forty-four long-term benzodiazepine users were randomly assigned to receive either electroacupuncture or placebo acupuncture (a sham itervention using non-invasive placebo needles) combined with a gradual benzodiazepine tapering schedule for 4 weeks. Read More
Mult Scler Relat Disord 2018 Nov 20;27:383-390. Epub 2018 Nov 20.
Department of Neurology, University of Colorado School of Medicine, 12700 East 19th Ave, B182, Aurora, CO 80045, United States. Electronic address:
Background: Studies suggest cannabis may improve symptoms like pain and muscle spasticity in patients with multiple sclerosis (PwMS). Despite cannabis' new-found legality and availability, few studies have explored the profile of PwMS cannabis users and characteristics of their use, particularly in a state where cannabis is legal both for recreational and medicinal use. The purpose of the current study was to evaluate cannabis use among PwMS at a large academic multiple sclerosis (MS) clinic, specifically: (1) prevalence, (2) products used (e. Read More
J Head Trauma Rehabil 2018 Nov 28. Epub 2018 Nov 28.
Murdoch Children's Research Institute, Melbourne, Australia (Ms Botchway and Drs Godfrey, Anderson, and Catroppa); The Royal Children's Hospital, Melbourne, Australia (Ms Botchway and Drs Godfrey, Anderson, and Catroppa); and Departments of Paediatrics (Ms Botchway and Drs Anderson and Catroppa) and Psychology (Drs Anderson and Catroppa), The University of Melbourne, Melbourne, Australia.
Objective: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI).
Methods: MEDLINE, PubMed, PsychInfo, Web of Science, and EMBASE databases were searched, reference lists of retrieved articles were also searched for relevant articles, and study methods were evaluated for risk of bias.
Results: Of the 620 articles assessed, 16 met inclusion criteria. Read More