23,117 results match your criteria Insomnia


Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations.

J Affect Disord 2019 Apr 9;252:350-357. Epub 2019 Apr 9.

Research and Knowledge Center, The Danish Veteran Center, Garnisonen 1, 4100 Ringsted, Denmark.

Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder that occurs with relatively high frequency after deployment to warzones (∼10%). While twin studies have estimated the heritability to be up to 40%, thus indicating a considerable genetic component in the etiology, the biological mechanisms underlying risk and development of PTSD remain unknown.

Methods: Here, we conduct a genome-wide association study (GWAS; N = 2,481) to identify genome regions that associate with PTSD in a highly homogenous, trauma-exposed sample of Danish soldiers deployed to war and conflict zones. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.070DOI Listing

Seasonal changes in sleep duration and sleep problems: A prospective study in Japanese community residents.

PLoS One 2019 18;14(4):e0215345. Epub 2019 Apr 18.

Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.

Background: A scientific understanding of the effects of seasonal changes on sleep duration and sleep problems such as insomnia and hypersomnia has yet to be elucidated; however, such an understanding could aid the establishment of an optimal sleep hygiene program to treat such problems.

Methods: We investigated the effects of seasonal changes on sleep duration and sleep problems in Japanese community residents. Data on 1,388 individuals aged 15-89 years who participated in the Survey of Seasonal Variations in Food Intakes conducted by the National Institute of Health and Nutrition of Japan (2004-2007) were analyzed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215345PLOS

Concomitant use of alcohol and benzodiazepine hypnotics in psychiatric outpatients: a cross-sectional survey.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Concomitant use of benzodiazepines and alcohol appears prevalent in a clinical setting. The objectives of this study were as follows: (1) to investigate the prevalence of concomitant use of benzodiazepine hypnotics and alcohol in psychiatric outpatients, (2) to examine the clinical characteristics and factors associated with the concomitant use, and (3) to investigate the awareness of the psychiatrists-in-charge about the concomitant use. Outpatients with schizophrenia, depression, and insomnia who were receiving benzodiazepine hypnotics were asked to fill in a sleeping diary for seven consecutive days in which use of hypnotics and alcohol was also recorded. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000264DOI Listing
April 2019
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The effects of aerobic exercise training on mental health and self-esteem of type 2 diabetes mellitus patients.

Health Psychol Res 2019 Mar 11;7(1):6576. Epub 2019 Mar 11.

Department of English, Zahedan University of Medical Sciences, Zahedan, Iran.

Physical and mental health are very closely tied and either of them can exert a significant effect on the other. The aim of the present study was to examine the effects of aerobic exercise training on mental health and self-esteem of type 2 diabetes mellitus patients. 60 participants, aged 40 to 55 years, with blood sugar ranging between 150 to 250 mg/dL participated in the study. Read More

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http://dx.doi.org/10.4081/hpr.2019.6576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441819PMC

A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager.

Authors:
Sergio U Dani

Swiss Med Wkly 2019 Apr 17;149:w20071. Epub 2019 Apr 17.

Medawar Institute for Medical and Environmental Research, Acangau Foundation, Paracatu, MG, Brazil, and PizolCare Praxis Sargans, Switzerland.

Arsenic is a toxicant that has no dose threshold below which exposures are not harmful. Here I report a curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. For about 4 years she had taken globules of a freely purchasable homeopathic remedy containing inorganic arsenic (iAs), infinitesimally diluted to D6 (average arsenic content per single globule: 0. Read More

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https://doi.emh.ch/smw.2019.20071
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http://dx.doi.org/10.4414/smw.2019.20071DOI Listing
April 2019
1 Read

Insomnia and the level of stress among students in Krakow, Poland.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):60-68. Epub 2019 Feb 4.

Department of Family Medicine, Jagiellonian University Medical College, Cracow, Poland.

Introduction: Stress and insomnia are increasing problems in young people in highly developed countries. They influence both the physical and psychological aspects of life and seem to be related to each other. Various strategies to cope with stress exist and can be used to reduce its level. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2237-6089-2017-0154DOI Listing
February 2019
2 Reads

Confirmatory factor analysis of the Insomnia Severity Index (ISI) and invariance across race: a pooled analysis of MsFLASH data.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

School of Nursing, Indiana University, Indianapolis, IN.

Objective: Women's sleep at menopause is widely reported to be problematic. The Insomnia Severity Index (ISI) is a commonly used tool for quantifying sleep problems in clinical and research settings, but psychometric properties in postmenopausal women have not been reported. Our study aim was to examine the factor structure of the ISI in a large and diverse sample of midlife women with hot flashes. Read More

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http://dx.doi.org/10.1097/GME.0000000000001343DOI Listing

Cannabis Use among Patients in a Rural Academic Palliative Care Clinic.

J Palliat Med 2019 Apr 17. Epub 2019 Apr 17.

1 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

Therapeutic cannabis is being more widely used by patients to manage multiple symptoms, but the patterns of use in the palliative care population are not well defined. The primary aim of this pilot study was to describe the use of cannabis among patients attending a palliative care clinic (PCC). The study was a retrospective chart review of patients seen at four different interval points during 2017 and 2018 in an ambulatory palliative care setting. Read More

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http://dx.doi.org/10.1089/jpm.2018.0534DOI Listing
April 2019
2 Reads

Higher amounts of Sedentary Time are Associated with Short Sleep Duration and Poor Sleep Quality in Postmenopausal Women.

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Study Objectives: To evaluate the associations between sedentary time, total (total-PA), light (light-PA), moderate (MOD-PA), and vigorous (VIG-PA) physical activity with indices of sleep in postmenopausal women.

Methods: Baseline self-reported data from the Women's Health Initiative Observational Study (n=75,074) were used in this cross-sectional analysis. Total-PA, light-PA, MOD-PA, and VIG-PA were categorized by metabolic equivalents of the activity [MET-hour (hr)/week (wk)] and were estimated using validated questionnaires. Read More

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http://dx.doi.org/10.1093/sleep/zsz093DOI Listing

Anti--methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Clinic for Geriatric Psychiatry, Psychiatric University Clinic, Zurich, Switzerland.

We present the case of a 77-year-old patient with a rapid onset of delusions, amnesia, agitation, insomnia and no previous psychiatric history, who was diagnosed with anti--methyl-d-aspartate receptor encephalitis. This case report highlights the importance of including autoimmune encephalitis in the differential diagnosis of older patients presenting with rapid onset psychiatric episodes. Read More

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http://dx.doi.org/10.1136/bcr-2018-228512DOI Listing

Tasimelteon for treating non-24-h sleep-wake rhythm disorder.

Expert Opin Pharmacother 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Sleep and Circadian Neurobiology Laboratory, Psychiatry and Behavior Sciences , Stanford University School of Medicine , Palo Alto , CA , USA.

Introduction: Non-24-h sleep-wake rhythm disorder (non-24) is observed in approximately half of totally blind individuals, a condition caused by their circadian pacemaker in the suprachiasmatic nucleus not being entrained to 24 h due to a lack of light perceptions. These subjects have a progressively delayed circadian cycle each day, non-24 periodically inducing nighttime insomnia and daytime sleepiness. Tasimelteon is a dual melatonin receptor agonist with high affinity for the melatonin 2 receptor, and it entrains endogenous melatonin rhythms and sleep-wake cycles in individuals with non-24. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1
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http://dx.doi.org/10.1080/14656566.2019.1603293DOI Listing
April 2019
1 Read

Pathogenesis and clinical features of the acute hepatic porphyrias (AHPs).

Mol Genet Metab 2019 Mar 6. Epub 2019 Mar 6.

Section on Gastroenterology & Hepatology, Wake Forest University School of Medicine/NC Baptist Hospital, Winston-Salem, NC 27157, United States of America.

The acute hepatic porphyrias include four disorders: acute intermittent porphyria [AIP], hereditary coproporphyria [HCP], variegate porphyria [VP], and the rare porphyria due to severe deficiency of ALA dehydratase [ADP]. In the USA, AIP is the most severe and most often symptomatic. AIP, HCP, and VP are due to autosomal dominant genetic abnormalities, in which missense, nonsense, or other mutations of genes of normal hepatic heme biosynthesis, in concert with other environmental, nutritional, hormonal and genetic factors, may lead to a critical deficiency of heme, the end-product of the pathway, in a small but critical 'regulatory pool' within hepatocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192193008
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http://dx.doi.org/10.1016/j.ymgme.2019.03.002DOI Listing
March 2019
1 Read

Neurobiological Mechanisms In Chronic Insomnia.

Sleep Med Clin 2009 Dec;4(4):549-558

Laboratory of Sleep & Behavioral Neuroscience, UCSD and VA San Diego Healthcare System, 3350 La Jolla Village Dr., MC 151B, Building 13, 3rd floor, San Diego, CA 92161.

This article grapples with the notion that insomnia can or should be defined in physiologic terms. It is proposed that insomnia is better understood from a neurobiological perspective. A review of the neurobiology of sleep and wakefulness is provided with a special emphasis on the implications for insomnia. Read More

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http://dx.doi.org/10.1016/j.jsmc.2009.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457449PMC
December 2009

Associations Between Lower Back Pain and Job Types in South Korean Male Firefighters.

Int J Occup Saf Ergon 2019 Apr 15:1-19. Epub 2019 Apr 15.

b Departments of Occupational and Environmental Medicine , Yonsei Wonju University College of Medicine Won-ju , Republic of Korea.

The aims of this study were to (1) compare the prevalence of LBP in firefighters according to job type and (2) identify the risk factors of LBP. A random sample of 277 male firefighters and 72 hospital office workers completed questionnaires and underwent lumbar spine MRI. The prevalence of LBP in firefighters (85. Read More

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http://dx.doi.org/10.1080/10803548.2019.1608061DOI Listing

Is work-associated stress converted into psychological distress among the staff nurses: A hospital-based study.

J Family Med Prim Care 2019 Feb;8(2):511-516

Department of Community Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut, India.

Introduction: "Stress is the subjective feeling produced by events that are uncontrollable." Constant stress brings about changes in the balance of hormones in the body which may lead to thoughts that make us feel frustrated, angry, nervous, anxious, etc., The aims of the study are (1) to find out the level of stress among staff nurses; (2) the association between sociodemographic determinants and working environment and stress; and (3) impact on their mental well-being in terms of somatic symptoms, anxiety/insomnia, social dysfunction, severe depression, and on work productivity. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_419_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436296PMC
February 2019

Editorial: Neuroimaging Findings in Sleep Disorders and Circadian Disruption.

Front Neurol 2019 21;10:249. Epub 2019 Mar 21.

Department of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

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https://www.frontiersin.org/article/10.3389/fneur.2019.00249
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http://dx.doi.org/10.3389/fneur.2019.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448031PMC
March 2019
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Effects of Insomnia and Depression on CPAP Adherence in a Military Population.

Fed Pract 2019 Mar;36(3):134-139

is a Clinical Nurse Specialist and is Chair of Pulmonary and Sleep Medicine, both in the Department of Pulmonary, Critical Care, and Sleep Medicine at the Naval Medical Center San Diego in California. is a Senior Scientist, Leidos and is a Sleep Research Physiologist, both in the Warfighter Performance Department of the Naval Health Research Center in San Diego.

Initial self-reported depression and insomnia prior to the diagnosis and treatment of obstructive sleep apnea with continuous positive airway pressure therapy did not reliably predict short- and long-term adherence in a sample of active-duty military and veteran patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453608PMC
March 2019
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Correlates of benzodiazepine dependence in patients with depression followed up in a psychiatric outpatient unit in Tunisia.

J Ethn Subst Abuse 2019 Apr 14:1-13. Epub 2019 Apr 14.

a Faculty of Medicine of Tunis , University of Tunis el Manar , Tunis , Tunisia.

Benzodiazepines may be prescribed to manage anxiety and insomnia in patients with depression. However, as noticed during our daily practice, a considerable proportion of patients treated for depression and receiving benzodiazepines developed a dependence to these medicines. Our aims were to estimate the proportion of patients with depression who develop a benzodiazepine dependence and to identify its correlates. Read More

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https://www.tandfonline.com/doi/full/10.1080/15332640.2019.1
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http://dx.doi.org/10.1080/15332640.2019.1589611DOI Listing
April 2019
3 Reads

Link between insomnia and perinatal depressive symptoms: A meta-analysis.

J Sleep Res 2019 Apr 14:e12858. Epub 2019 Apr 14.

Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Evidence shows the possible link between insomnia and perinatal depressive symptoms. In order to find a convergent quantitative answer, we collected data via the search of Medline, EMBASE and reference tracking, which included nine studies (a total sample of 1,922 women). An aggregate effect size estimate (correlation coefficient) was generated using the comprehensive meta-analysis software. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12858
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http://dx.doi.org/10.1111/jsr.12858DOI Listing
April 2019
1 Read

Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey - Adolescent Supplement (NCS-A).

Cephalalgia 2019 Apr 13:333102419835466. Epub 2019 Apr 13.

1 Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

Background: There is limited research on the association of sleep problems with International Classification of Headache Disorders (ICHD-II)-defined headache subtypes in youth, particularly from community-based samples. This cross-sectional study examines the associations of sleep patterns, symptoms and disorders with specific headache subtypes among adolescents from the general population of the United States.

Methods: The sample includes 10,123 adolescents in the National Comorbidity Survey - Adolescent Supplement, a face-to-face survey of adolescents aged 13-18 years in the continental USA. Read More

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http://dx.doi.org/10.1177/0333102419835466DOI Listing
April 2019
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Midazolam: Safety of use in palliative care: A systematic critical review.

Biomed Pharmacother 2019 Apr 10;114:108838. Epub 2019 Apr 10.

Department of Palliative Medicine, Poznan University of Medical Sciences, Poland.

Purpose: The undesired effects of midazolam can be life-threatening. This paper delineates the findings related to the pharmacokinetics, adverse effects and drug-drug interactions as well as associated therapeutic implications for safe midazolam use.

Methods: A systematic review of literature was conducted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322193059
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http://dx.doi.org/10.1016/j.biopha.2019.108838DOI Listing
April 2019
3 Reads

Depression in adolescent girls: Relationship to serum vitamins a and E, immune response to heat shock protein 27 and systemic inflammation.

J Affect Disord 2019 Apr 8;252:68-73. Epub 2019 Apr 8.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: The inflammation and oxidative stress are thought to play an important role in the etiopathogenesis of some psychological disorders. We aimed to assess the potential relationships between serum fat soluble vitamins (Vitamins A and E), antibody titers to Hsp27 (anti-Hsp27) and hematological markers of inflammation, with mood disorders in a population of adolescent girls.

Methods: A total of 563 adolescent girls (Age 12-18 years) were included in the study. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.048DOI Listing
April 2019
1 Read

Prospective associations between insomnia symptoms and alcohol use problems among former and current military service personnel.

Drug Alcohol Depend 2019 Apr 6;199:35-41. Epub 2019 Apr 6.

College of Nursing, Medical University of South Carolina, 99 Jonathan Lucas St, Charleston, SC, 29425, USA.

Background: Despite evidence that insomnia symptoms exacerbate alcohol use disorder symptoms, there is a dearth of prospective research testing bidirectional associations between these variables. Furthermore, no studies have prospectively examined these associations among military personnel, a vulnerable population for sleep- and alcohol-related problems. Thus, the current study examined whether insomnia symptoms prospectively predicted increased alcohol use disorder symptoms among a sample of military service members and veterans over a 6-month follow-up period, as well as whether alcohol use disorder symptoms led to increases in insomnia. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.02.018DOI Listing

Quality of life assessment for patients undergoing irreversible electroporation (IRE) for treatment of locally advanced pancreatic cancer (LAPC).

Am J Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY, USA. Electronic address:

Background: IRE is a non-thermal ablative modality that has been shown to be safe and efficacious in LAPC and liver tumors, but few studies have shown its effects on patients' (QOL). The goal of this study is to evaluate quality-of-life (QOL) before and after irreversible electroporation (IRE) therapy for treatment of locally advanced pancreatic carcinoma (LAPC).

Methods: Between 11/2014 and 12/2016, patients scheduled for IRE therapy for LAPC were offered QOL questionnaires (EORTC QLQ-C30 V2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029610183140
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http://dx.doi.org/10.1016/j.amjsurg.2019.03.020DOI Listing
April 2019
2 Reads

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

Cochrane Database Syst Rev 2019 Apr 12;4:CD012680. Epub 2019 Apr 12.

School of Psychology, Deakin University Geelong, 221 Burwood Highway, Burwood, VIC, Victoria, Australia, 3025.

Background: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD. Read More

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http://doi.wiley.com/10.1002/14651858.CD012680.pub2
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http://dx.doi.org/10.1002/14651858.CD012680.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459769PMC
April 2019
2 Reads

Sexual orientation and sleep difficulties: a review of research.

Sleep Health 2019 Apr 8. Epub 2019 Apr 8.

University of Virginia.

Is sexual orientation associated with sleep difficulties? In this article, we review empirical evidence that addresses this question. Stress is associated with sleep difficulties such as insomnia and, because members of sexual minorities experience greater stress, on average, than do others, lesbian, gay, and bisexual (LGB) individuals can be expected to report more sleep difficulties than their heterosexual peers. We reviewed 17 studies published since 1990, with data gathered from more than 600,000 individuals; some included data on both quantity and quality of sleep. Read More

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http://dx.doi.org/10.1016/j.sleh.2019.02.004DOI Listing
April 2019
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Sleep disorders in NiemannPick disease type C, beyond cataplexy.

Sleep Med 2019 Feb 19;57:122-127. Epub 2019 Feb 19.

Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Brazil; Neurology Service, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Purpose: The aim of this study was to clinically characterize sleep disorders in a cohort of Niemann-Pick type C (NPC) patients, correlating these findings with disease features and polysomnographic (PSG) results.

Methods: We evaluated eight consecutive patients with molecular confirmation of NPC followed at the Hospital Geral de Fortaleza. Patients underwent a comprehensive neurological and sleep evaluation. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.02.007DOI Listing
February 2019
2 Reads

Depression and Insomnia Are Closely Associated with Thyroid Hormone Levels in Chronic Hepatitis B.

Med Sci Monit 2019 Apr 11;25:2672-2678. Epub 2019 Apr 11.

Department of Digestive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

BACKGROUND Depression and insomnia in chronic hepatitis B (CHB) patients affect the quality of life, disease diagnosis, and mortality. CHB patients are more likely to have psychological disorders, but the underlying mechanisms have not been elucidated. This study investigated the incidence of depression in patients with CHB and sought to identify risk factors for depression and insomnia in these patients, focusing on changes in liver function and thyroid hormone levels. Read More

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https://www.medscimonit.com/abstract/index/idArt/914444
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http://dx.doi.org/10.12659/MSM.914444DOI Listing
April 2019
3 Reads

Effectiveness of Internet-Delivered Computerized Cognitive Behavioral Therapy for Patients With Insomnia Who Remain Symptomatic Following Pharmacotherapy: Randomized Controlled Exploratory Trial.

J Med Internet Res 2019 Apr 11;21(4):e12686. Epub 2019 Apr 11.

Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: In reality, pharmacotherapy still remains the most common treatment for insomnia.

Objective: This study aimed to examine the effectiveness of our internet-delivered computerized cognitive behavioral therapy (ICBT) program as an adjunct to usual care (UC) compared with UC alone in patients with insomnia who remain symptomatic following hypnotics.

Methods: We recruited 23 patients with insomnia who remained symptomatic following pharmacologic treatment including benzodiazepines, and we conducted an exploratory randomized controlled trial. Read More

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http://dx.doi.org/10.2196/12686DOI Listing
April 2019
2 Reads

Intensive Care Units of a Tertiary Care Hospital: A Detailed Study of Patient Symptomatology.

Cureus 2019 Jan 30;11(1):e3988. Epub 2019 Jan 30.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Introduction Nosocomial infection (NI) is a factor of considerable significance in determining the morbidity and mortality of patients admitted to the intensive care units (ICUs). Our aim was to study the frequencies of various symptoms that might emerge due to nosocomial infection (NI) among ICU patients. Materials and methods This was a cross-sectional study conducted in intensive care units of General Medicine, General Surgery and Paediatric wards in Ruth M. Read More

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https://www.cureus.com/articles/17348-intensive-care-units-o
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http://dx.doi.org/10.7759/cureus.3988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443531PMC
January 2019
6 Reads

Impact of Cognitive Dysfunction in the Middle East Depressed Patients: The ICMED Study.

Clin Pract Epidemiol Ment Health 2018 31;14:270-283. Epub 2018 Oct 31.

Psychiatric Departments, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

Background: Major depressive disorder is a common condition with a high rate of recurrence, chronicity, and affecting economic burden, including disability in the workplace, which leads to negative consequences on both individuals and society.

Objectives: This study aimed to estimate the impact of cognitive dysfunction, as declared by the patient, on performing daily tasks/activities among patients with major depression disorder (MDD).

Methods: This investigation is based on multinational cross-sectional survey of 499 workers recruited from the Kingdom of Saudi Arabia (KSA) and United Arab Emirates (UAE). Read More

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http://dx.doi.org/10.2174/1745017901814010270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407647PMC
October 2018
1 Read

Cognitive Behavioral Therapy for Prenatal Insomnia: A Randomized Controlled Trial.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Stanford University, Stanford, California; Monash University, Melbourne, Australia; and Santa Clara Valley Medical Center, Fruitdale, California.

Objective: To evaluate the effectiveness of cognitive behavioral therapy for insomnia during pregnancy.

Methods: Randomized, unmasked, 3-site controlled trial. Participants were randomly allocated to cognitive behavioral therapy for insomnia (a first-line, empirically supported psychosocial intervention that addresses sleep-related behaviors and cognitions) or a control intervention consisting of imagery exercises that paired patient-identified distressing nighttime experiences with patient-identified neutral images. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003216DOI Listing
April 2019
1 Read

The key role of insomnia and sleep loss in the dysregulation of multiple systems involved in mood disorders: A proposed model.

J Sleep Res 2019 Apr 10:e12841. Epub 2019 Apr 10.

Department of Clinical Psychology and Psychophysiology/Sleep Medicine, Center for Mental Disorders, University of Freiburg, Freiburg, Germany.

Mood disorders are amongst the most prevalent and severe disorders worldwide, with a tendency to be recurrent and disabling. Although multiple mechanisms have been hypothesized to be involved in their pathogenesis, just a few integrative theoretical frameworks have been proposed and have yet to integrate comprehensively all available findings. As such, a comprehensive framework would be quite useful from a clinical and therapeutic point of view in order to identify elements to evaluate and target in the clinical practice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12841
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http://dx.doi.org/10.1111/jsr.12841DOI Listing
April 2019
2 Reads

Unmasking the True Face of Postural Orthostatic Tachycardia Syndrome.

Authors:
Artur Fedorowski

J Intern Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Clinical Research Center, 214 28, Malmö, Sweden.

Not so long time ago, in 1930s, younger and, in particular, female patients presenting with a myriad of such symptoms as palpitations, non-specific chest pain, weakness, insomnia, faintness, dizziness, irritability and flushes were seen as representative of "cardiac neurosis"[1]. The "cardiac neurosis" was believed to be a psychosomatic disorder but the term is largely forgotten by modern cardiology. And there is a good reason for it. Read More

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http://dx.doi.org/10.1111/joim.12917DOI Listing
April 2019
1 Read

Psychopathological symptoms associated with synthetic cannabinoid use: a comparison with natural cannabis.

Psychopharmacology (Berl) 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Background: Synthetic cannabinoids (SCs) are a class of new psychoactive substances that have been rapidly evolving around the world throughout recent years. Many different synthetic cannabinoid analogues are on the consumer market and sold under misleading names, like "spice" or "incense." A limited number of studies have reported serious health effects associated with SC use. Read More

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http://dx.doi.org/10.1007/s00213-019-05238-8DOI Listing
April 2019
3 Reads

Association between sleep disturbance in Alzheimer's disease patients and burden on and health status of their caregivers.

J Neurol 2019 Apr 9. Epub 2019 Apr 9.

Medical Affairs, MSD K.K., Kitanomaru Square, 1-13-12 Kudan-kita, Chiyoda-ku, Tokyo, 102-8667, Japan.

Background: Sleep disturbance in Alzheimer's disease (AD) patients may have a negative impact not only on patients themselves but also on the physical and mental health of their caregivers. Detailed analysis of these issues is lacking.

Objective: This study investigated the association between sleep disturbance in AD patients and the burden on, and health status of, their caregivers in Japan. Read More

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http://dx.doi.org/10.1007/s00415-019-09286-0DOI Listing
April 2019
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Hypothalamic-Pituitary-Gonadal Activity in Paradoxical and Psychophysiological Insomnia.

J Med Signals Sens 2019 Jan-Mar;9(1):59-67

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Although insomnia is a sex-dimorphic disorder, there is limited knowledge about the association between sex hormones and insomnia. In the present study, the level of hypothalamus-pituitary-gonadal (HPG) axis activity was investigated in patients with insomnia by measuring serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), 17α-Hydroxyprogesterone, testosterone, progesterone, estradiol, dehydroepiandrosterone sulfate, and sex hormone-binding globulin.

Methods: Numbers of 19 patients; including 13 females (68. Read More

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http://dx.doi.org/10.4103/jmss.JMSS_31_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419559PMC
April 2019
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Secondary Traumatic Stress: Relationship With Symptoms, Exhaustion, and Emotions Among Cemetery Workers.

Front Psychol 2019 22;10:633. Epub 2019 Mar 22.

Carlo A. Ricciardi Department of Business, Law, Economics and Consumer Behaviour, Università IULM, Milan, Italy.

Cemeteries workers are deserving of attention because they are exposed to various psychosocial risks: these workers are subject to painful contacts and daily exposed to a work content linked to death experiences and the emotions associated with them. Secondary trauma develops from this continuous contact with others' suffering; operators working with this type of traumatic content and dynamic could suffer from emotional disorders (Figley, 1995). Therefore, the secondary traumatic stress (STS) is seen as an occupational risk factor (Bride et al. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438950PMC
March 2019
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Stimulant Therapy in Acute Traumatic Brain Injury: Prescribing Patterns and Adverse Event Rates at 2 Level 1 Trauma Centers.

J Intensive Care Med 2019 Apr 9:885066619841603. Epub 2019 Apr 9.

4 Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background/objective: Pharmacological stimulant therapies are routinely administered to promote recovery in patients with subacute and chronic disorders of consciousness (DoC). However, utilization rates and adverse drug event (ADE) rates of stimulant therapies in patients with acute DoC are unknown. We aimed to determine the frequency of stimulant use and associated ADEs in intensive care unit (ICU) patients with acute DoC caused by traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1177/0885066619841603DOI Listing
April 2019
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Combined Program of Cognitive-Behavioral Therapy for Insomnia and Medication Tapering in Cancer Patients: A Clinic-Based Pilot Study.

Behav Sleep Med 2019 Apr 9:1-10. Epub 2019 Apr 9.

b Mental Health Clinic, National Cancer Center , Gyeonggi-do , Republic of Korea.

Objective: This preliminary study aimed to evaluate the efficacy of a combined program of group-based cognitive-behavioral therapy for insomnia (CBT-I) and medication tapering for reducing hypnotic use in cancer patients and to identify predictors of medication continuation.

Participants: This study has a retrospective design and uses archival data from patient's medical records. Forty cancer patients with chronic insomnia received clinic- and group-based CBT-I alongside a medication tapering program. Read More

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http://dx.doi.org/10.1080/15402002.2019.1597718DOI Listing
April 2019
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Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature.

Behav Brain Res 2019 Apr 6;367:215-220. Epub 2019 Apr 6.

Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address:

Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.008DOI Listing
April 2019
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Evaluation of efficacy and safety of apatinib treatment in advanced gastric cancer.

J Cancer Res Ther 2019 ;15(2):365-369

Department of Medical Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230061, China.

Aim: We aimed to evaluate the efficacy and safety of apatinib treatment and its impact on the quality of life (QOL) of patients with advanced gastric cancer (GC) who experienced failure with at least two chemotherapeutic regimens.

Materials And Methods: All patients received apatinib at a daily dose of 500 mg for 4 weeks per cycle until it was stopped due to disease progression, intolerable toxicity. Response Evaluation Criteria in Solid Tumors version 1. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_297_18DOI Listing
January 2019
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Indirect Comparison of Ropinirole and Pramipexole as Levodopa Adjunctive Therapy in Advanced Parkinson's Disease: A Systematic Review and Network Meta-Analysis.

Adv Ther 2019 Apr 8. Epub 2019 Apr 8.

GlaxoSmithKline, Collegeville, PA, USA.

Introduction: To evaluate the comparative efficacy and safety of ropinirole and pramipexole as adjunctive therapies to levodopa (L-dopa) for the management of advanced Parkinson's disease (PD), via a systematic review and network meta-analysis.

Methods: Twenty-one double-blind randomised controlled trials of patients with advanced PD with motor fluctuations receiving L-dopa comparing ropinirole or pramipexole with comparators were identified from 2550 publications. Bayesian indirect comparison methods were applied to independently review efficacy outcomes including off-time reduction, Unified Parkinson's Disease Rating Scale-Activity of Daily Living (UPDRS-ADL) and UPDRS-motor scores, and safety outcomes including adverse events (AE) and patient withdrawals, to determine indirect treatment comparison mean differences (MD) or hazard ratios (HR) with 95% confidence intervals (CI). Read More

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http://dx.doi.org/10.1007/s12325-019-00938-1DOI Listing
April 2019
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Digital cognitive behavioral therapy for insomnia - The first Georgian version. Can we use it in practice?

Internet Interv 2019 Sep 9;17:100244. Epub 2019 Mar 9.

Vrije Universiteit Amsterdam, Netherlands.

Insomnia is a common sleep disorder which has a 5-6% prevalence rate and shows high social impact. At least 10% of patients with insomnia will see a medical specialist. Hence, 20,000-40,000 people in Georgia require medical help for insomnia. Read More

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http://dx.doi.org/10.1016/j.invent.2019.100244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434187PMC
September 2019
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Psychiatric symptoms and their association with sleep disturbances in intensive care unit survivors.

Int J Gen Med 2019 22;12:125-130. Epub 2019 Mar 22.

Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN, USA,

Background: Sleep disturbances in critically ill patients are associated with poorer long-term clinical outcomes and quality of life. Studies are needed to better characterize associations and risk factors for persistent sleep disturbances after intensive care unit (ICU) discharge. Psychiatric disorders are frequently associated with sleep disturbances, but the role of psychiatric symptoms in sleep disturbances in ICU survivors has not been well-studied. Read More

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http://dx.doi.org/10.2147/IJGM.S193084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434907PMC
March 2019
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Cardiovascular health and sleep disturbances in two population-based cohort studies.

Heart 2019 Apr 8. Epub 2019 Apr 8.

Universite Paris Descartes, Paris, France.

Objective: We aimed to investigate the association between cardiovascular health (CVH), as defined by the American Heart Association, and several sleep disturbances.

Methods: Two community-based cohorts, the Paris Prospective Study 3 (PPS3, France, n=6441) and the CoLaus study (Switzerland, n=2989) were analysed. CVH includes 7 metrics which all can be classified as poor, intermediate and ideal. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314485DOI Listing
April 2019
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Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact.

Neurologia 2019 Apr 5. Epub 2019 Apr 5.

Departamento de Neurología, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address:

Introduction: Restless legs syndrome (RLS) is a disorder characterised by an irresistible urge to move the legs, usually accompanied by unpleasant sensations. It is more frequent in patients with multiple sclerosis (MS) than in the general population.

Objectives: To evaluate the prevalence of RLS, defined according to the 4 essential requirements included in the diagnostic criteria proposed by the International Restless Leg Syndrome Study Group, in a cohort of patients with MS; and to identify potential risk factors and the clinical impact of RLS. Read More

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http://dx.doi.org/10.1016/j.nrl.2018.12.010DOI Listing
April 2019
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The Association between Health Conditions in World Trade Center Responders and Sleep-Related Quality of Life and Sleep Complaints.

Int J Environ Res Public Health 2019 Apr 6;16(7). Epub 2019 Apr 6.

Division of Pulmonary and Critical Care Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.

World Trade Center (WTC) dust-exposed subjects have multiple comorbidities that affect sleep. These include obstructive sleep apnea (OSA), chronic rhinosinusitis (CRS), gastroesophageal-reflux disorder (GERD) and post-traumatic stress disorder (PTSD). We examined the impact of these conditions to sleep-related outcomes. Read More

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http://dx.doi.org/10.3390/ijerph16071229DOI Listing
April 2019
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