209,342 results match your criteria Insights into imaging[Journal]


MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.

Biomed Pharmacother 2018 Dec 14;110:850-856. Epub 2018 Dec 14.

Department of Gynaecology and Obstetrics, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China. Electronic address:

MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. Read More

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December 2018

Ambient PM air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study.

Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More

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December 2018

Gaze allocation in face-to-face communication is affected primarily by task structure and social context, not stimulus-driven factors.

Cognition 2018 Dec 14;184:28-43. Epub 2018 Dec 14.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; Developmental Psychology, Utrecht University, Utrecht, the Netherlands; Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands.

Gaze allocation to human faces has recently been shown to be greatly dependent on the social context. However, what has not been considered explicitly here, is how gaze allocation may be supportive of the specific task that individuals carry out. In the present study, we combined these two insights. Read More

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December 2018

Construct validity of six sentiment analysis methods in the text of encounter notes of patients with critical illness.

J Biomed Inform 2018 Dec 14. Epub 2018 Dec 14.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Sentiment analysis may offer insights into patient outcomes through the subjective expressions made by clinicians in the text of encounter notes. We analyzed the predictive, concurrent, convergent, and content validity of six sentiment methods in a sample of 793,725 multidisciplinary clinical notes among 41,283 hospitalizations associated with an intensive care unit stay. None of these approaches improved early prediction of in-hospital mortality using logistic regression models, but did improve both discrimination and calibration when using random forests. Read More

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December 2018

Understanding the transition from water to land: Insights from multi-omic analyses of the perivitelline fluid of apple snail eggs.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Hong Kong Baptist University, Hong Kong, China; HKBU Institute of Research and Continuing Education, Shenzhen, China. Electronic address:

Most gastropods deposit their eggs either on land or underwater, but the family Ampullariidae includes members that exhibit both underwater and aerial oviposition, making it an ideal model for understanding mechanisms underlying the evolutionary transition from water to land. We applied SDS-PAGE and LC-MS/MS to analyse the proteome of the egg perivitelline fluid (PVF) of Marisa cornuarietis - an aquatic ovipositing ampullariid. Comparison with the reported PVF proteomes of two aerial ovipositing ampullariids (Pomacea canaliculata and P. Read More

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December 2018

Macromolecular crowding and membrane binding proteins: the case of phospholipase A.

Chem Phys Lipids 2018 Dec 14. Epub 2018 Dec 14.

Division of Chemistry, School of Pharmacy and Biological Sciences, University of Brighton, BN2 4GL, United Kingdom. Electronic address:

Cells contain high levels of macromolecular crowding; understanding how macromolecular crowding impacts the behaviour of biological systems can give new insights into biological phenomena and disease pathologies. In this study, we assess the effect of macromolecular crowding on the catalytic activity of the biomembrane binding protein phospholipase A (PLA). Using 3D-printed equilibrium dialysis chambers we show that macromolecular crowding increases the binding of PLA to lipid vesicles. Read More

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December 2018

An Approach for Guiding the Development and Assessing the Interdisciplinarity of New Methodologies for Community Disaster Resilience.

Authors:
Elaina J Sutley

Risk Anal 2018 Dec 17. Epub 2018 Dec 17.

There are critical and preventable inequalities in disaster impacts and postdisaster recovery. To formulate solutions for minimizing or preventing these unequal impacts, there is a great need for interdisciplinary methodologies that use social factors to set project scopes and drive engineering analyses and designs. At present time, however, limited guidance exists on how to develop and execute interdisciplinary methodologies, especially related to the study of community disaster resilience. Read More

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December 2018

EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.

PLoS Pathog 2018 Dec 17;14(12):e1007484. Epub 2018 Dec 17.

Shenzhen Key Laboratory of Viral Oncology, the Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Read More

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December 2018

The CbrB Regulon: Promoter dissection reveals novel insights into the CbrAB expression network in Pseudomonas putida.

PLoS One 2018 17;13(12):e0209191. Epub 2018 Dec 17.

Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo/ Consejo Superior de Investigaciones Científicas/ Junta de Andalucía, Seville, Spain.

CbrAB is a high ranked global regulatory system exclusive of the Pseudomonads that responds to carbon limiting conditions. It has become necessary to define the particular regulon of CbrB and discriminate it from the downstream cascades through other regulatory components. We have performed in vivo binding analysis of CbrB in P. Read More

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December 2018

Insights into life after sport for Spanish Olympians: Gender and career path perspectives.

PLoS One 2018 17;13(12):e0209433. Epub 2018 Dec 17.

Department of Social Sciences Applied to Sport, Physical Activity and Leisure, Sport Sciences Faculty, Universidad Politécnica de Madrid, Madrid, Spain.

The aims of this study were: i) to examine if Dual Career (DC) pathways are independent of gender, ii) to evaluate whether those athletes who followed a DC experienced less difficulty in their integration into the labor force than the athletes devoted entirely to sport regardless of gender, as well as iii) to analyze whether the type of career path chosen was related with the current labor status, and if differences exist between men and women athletes. A quantitative, cross-sectional, and descriptive study was used based on an ad hoc questionnaire. Two-hundred and twenty-eight retired Olympic athletes completed a questionnaire. Read More

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December 2018

Health seeking for chronic lung disease in central Malawi: Adapting existing models using insights from a qualitative study.

PLoS One 2018 17;13(12):e0208188. Epub 2018 Dec 17.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

Background: Chronic lung diseases contribute to the growing non-communicable disease (NCD) burden and are increasing, particularly in many low and middle-income countries (LMIC) in sub-Saharan African. Early engagement with health systems in chronic lung disease management is critical to maintain quality of life and prevent further damage. Our study sought to understand health seeking behaviour in relation to chronic lung disease and TB in a rural district in Malawi. Read More

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December 2018
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Adapted Dance Improves Motor Abilities and Participation in Children With Down Syndrome: A Pilot Study.

Pediatr Phys Ther 2019 Jan;31(1):76-82

Division of Occupational Therapy and Physical Therapy (Ms McGuire and Drs Long and Bailes) and Division of Developmental and Behavioral Pediatrics (Dr Esbensen), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Purpose: This pilot study measured effects of an adapted dance program on motor abilities and participation in children with Down syndrome (DS) and explored caregivers' qualitative feedback regarding its benefits.

Methods: Children with DS participated in 20 weekly 1-hour adapted dance sessions. The Canadian Occupational Performance Measure (COPM) and Gross Motor Function Measure (GMFM) Dimensions D and E were administered before and after the program. Read More

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January 2019

The Transcriptional Signature of a Runner's High.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

SUNY Upstate Medical University, Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology, Pediatrics, and Psychiatry & Behavioral Sciences, Syracuse NY.

Introduction: Endorphins, endocannabinoids, monoamines, and neurotrophins have all been implicated in the euphoric response to endurance running, known as a runner's high. The epi-transcriptional mechanisms regulating this effect have not been defined. Here, we investigate peripheral micro-ribonucleic acid (miRNA) changes unique to athletes experiencing post-run euphoria, yielding insights about gene networks that control a runner's high. Read More

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December 2018

New insights into the pathophysiology of IgG4-related disease and markers of disease activity.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

a Division of Rheumatology, Department of Internal Medicine , Kanazawa University Graduate School of Medicine , Kanazawa , Japan.

Introduction: Recently, IgG4-related disease (IgG4-RD) has become a well-recognized clinical entity, although its causes are still not well understood. The pathophysiology of IgG4-RD has been reported from a variety of aspects. Areas covered: In this review, we outline a number of recent advances in our understanding of the pathogenesis of IgG4-RD, divided according to acquired immunology and innate immunology and other topics. Read More

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December 2018

The mA writer: Rise of a machine for growing tasks.

Biochemistry 2018 Dec 17. Epub 2018 Dec 17.

The central dogma of molecular biology introduced by Crick describes a linear flow of information from DNA to mRNA to protein. Since then it has become evident that RNA undergoes several maturation steps such as capping, splicing, 3'-end processing and editing. Likewise, nucleotide modifications are common in mRNA and are present in all organisms impacting on the regulation of gene expression. Read More

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December 2018

Structural basis for the interaction and processing of β-lactam antibiotics by L,D- transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis.

ACS Infect Dis 2018 Dec 17. Epub 2018 Dec 17.

Targeting Mycobacterium tuberculosis peptidoglycans with β-lactam antibiotics represents a strategy to address increasing resistance to anti-tubercular drugs. β-Lactams inhibit peptidoglycan synthases such as L,D-transpeptidases, a group of carbapenem-sensitive enzymes that stabilize peptidoglycans through 3→3 cross-links. M. Read More

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December 2018

A Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines.

ACS Chem Biol 2018 Dec 17. Epub 2018 Dec 17.

The cyanobacterial genus Microcystis is known to produce an elaborate array of structurally unique and biologically active natural products including hazardous cyanotoxins. Cytotoxic aeruginoguanidines represent a yet unexplored family of peptides featuring a trisubstituted benzene unit and farnesylated arginine derivatives. In this study, we aimed at assigning these compounds to a biosynthetic gene cluster by utilizing biosynthetic attributes deduced from public genomes of Microcystis and the sporadic distribution of the metabolite in axenic strains of the Pasteur Culture Collection of Cyanobacteria. Read More

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December 2018

Using OmicsNet for Network Integration and 3D Visualization.

Curr Protoc Bioinformatics 2018 Dec 17:e69. Epub 2018 Dec 17.

Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada.

OmicsNet is a novel web-based tool for creating and visualizing complex biological networks in 3D space. By coupling a comprehensive knowledgebase with the powerful WebGL technology, OmicsNet allows researchers to intuitively explore molecular interactions and regulatory relationships among genes, transcription factors, microRNAs, and metabolites. OmicsNet fills an important gap by facilitating multi-omics integration and systems biology. Read More

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December 2018
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Gene networks orchestrated by MeGI: a single-factor mechanism underlying sex determination in persimmon.

Plant J 2018 Dec 17. Epub 2018 Dec 17.

Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.

Separating male and female sex organs is one of the main strategies used to maintain genetic diversity within a species. However, the genetic determinants and their regulatory mechanisms have been identified in only a few species. In dioecious persimmons, the homeodomain transcription factor, MeGI, which is the target of a Y chromosome-encoded small-RNA, OGI, can determine floral sexuality. Read More

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December 2018
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Overexpression of miR-3196 suppresses cell proliferation and induces cell apoptosis through targeting ERBB3 in breast cancer.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8383-8390

Department of General Surgery, Changji Huizu People's Hospital of Xinjiang, Xinjiang, China.

Objective: Breast cancer is one of the most common malignancies worldwide. MicroRNAs (MiRNAs) have been identified to influence cell behaviors through epigenetic post-transcriptional gene regulation. Therefore, the aim of this study was to determine the role of miR-3196 in the proliferation and apoptosis of breast cancer. Read More

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December 2018

Rational chemical doping of metal halide perovskites.

Chem Soc Rev 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Metal halide perovskites benefit from the combination of wide absorption, high carrier mobility, defect tolerance, moderate exciton binding energies, and versatility of solution processes, showing great promise in photovoltaics and optoelectronics. However, the issues of long-term instability and toxicity of lead are supposed to limit their further practical applications. Chemical doping of an impurity into metal halide perovskites was reported to be a relatively effective approach to solving these issues while providing additional tunable physical and chemical properties. Read More

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December 2018

Theoretical insights into photo-induced electron transfer at BiOX (X = F, Cl, Br, I) (001) surfaces and interfaces.

Phys Chem Chem Phys 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, China.

The electron transfer process (ETP) of a photocatalyst plays a crucial role in clarifying its photoelectrochemical catalytic mechanism. BiOX (X = F, Cl, Br, I) (001) surfaces display excellent photocatalytic performance due to the high separation efficiency of photogenerated electron-hole (e--h+) pairs in their own efficient internal electric field (IEF). The oxygen vacancies (OVs) on the surfaces could cause a change in localized electronic states, then improve the photocatalytic activity of BiOX. Read More

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December 2018

Measurement of patient-reported outcomes. 1: The search for the Holy Grail.

J Med Econ 2018 Dec 17. Epub 2018 Dec 17.

c MetaMetrics Inc , Durham NC , USA.

Patient-reported outcome measures (PROMs) are used to collect information directly from patients. They may cover several different types of outcomes ranging from symptoms, functioning, utility, satisfaction through to quality of life (QoL). They generally consist of self-completed questionnaires that can be administered by means of hard copies or in a range of electronic formats. Read More

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December 2018

Patterns of positive and negative work reflection during leisure time: A latent profile analysis.

J Occup Health Psychol 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychology, University of Mannheim.

This study examined positive and negative work reflection during leisure time from a person-centered perspective using latent profile analysis. First, we examined whether quantitatively and qualitatively different work reflection profiles exist. Second, we investigated whether persons with different work reflection profiles differ in energetic well-being (i. Read More

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December 2018

National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries.

Pediatr Endocrinol Rev 2018 Dec;16(2):240-255

Genentech, 1 DNA Way, MS #4F, South San Francisco, CA 94080, USA, E-mail:

Background: The National Cooperative Growth Study (NCGS) data are reviewed from 1985-2010 to report on final demographic, efficacy, and safety findings, and to illustrate the value of long-term, real-world follow-up to physicians and patients.

Methods: The NCGS was a multicenter, open-label, observational, postmarketing surveillance study of Genentech growth hormone (GH) products for the treatment of children with growth failure in North America.

Findings: Data from 65,205 patients representing 240,951 patient-years of experience were collected. Read More

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December 2018

Development of a multivariate prediction model for nocturia, based on urinary tract etiologies.

Int J Clin Pract 2018 Dec 16:e13306. Epub 2018 Dec 16.

Universiteit Gent Faculteit Geneeskunde en Gezondheidswetenschappen, Department of Uro-gynaecology, St. Pietersnieuwstraat 33, Gent, 9000, Belgium.

Purpose: The main objective of our study was to determine which combination of modifiable and non-modifiable parameters that could discriminate patients with nocturia from those without nocturia. This will allow to study the etiology of nocturia and to estimate the treatment effect that address bladder capacity or nocturnal urine production on the number of nocturnal voids without need to uniform definitions for nocturnal polyuria or a reduced functional bladder capacity.

Method: This was a post-hoc analysis of 3 prospective, observational studies conducted in Ghent University. Read More

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December 2018

Inhibition of α-amylase activity by Zn2+: insights from spectroscopy and molecular dynamics simulations.

Med Chem 2018 Dec 16. Epub 2018 Dec 16.

College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004 . China.

Background: Inhibition of α-amylase activity is an important strategy in the treatment of diabetes mellitus. An important treatment for diabetes mellitus is to reduce the digestion of carbohydrates and blood glucose concentrations. Inhibiting the activity of carbohydrate-degrading enzymes such as α-amylase and glucosidase significantly decreases the blood glucose level. Read More

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December 2018

Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Division of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. United States.

Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. Read More

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December 2018

Procuring Health: Experiences of Mexican Immigrant Women in Rural Midwestern Communities.

Qual Health Res 2018 Dec 17:1049732318816676. Epub 2018 Dec 17.

2 Tulsa Community College, Tulsa, Oklahoma, USA.

Thematic analysis was used to analyze interview data from 15 first-generation Mexican immigrant women who resided in two rural Midwestern communities. Ten themes were identified and aligned with four thematic areas of interest ( meaning of being healthy, strategies to promote health, challenges to health, and supports for health). This study provides insights into the complexities and realities faced by Mexican immigrant women, as they strove to obtain optimal health in rural America, and contributes to the growing literature focused on health disparities among ethnic and racial minorities. Read More

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December 2018

What Do Medical Students Do and Want When Caring for "Difficult Patients"?

Teach Learn Med 2018 Dec 15:1-12. Epub 2018 Dec 15.

b Department of Medicine , University of California , San Francisco , California , USA.

Phenomenon: Medical students, like physicians, experience negative emotions such as frustration when interacting with some patients, and many of these interactions occur for the first time during clinical clerkships. Students receive preclinical training in the social and behavioral sciences, often including learning about "difficult patient" interactions, yet little is known about their desire for training during clinical education. We explored students' strategies in these difficult clinical interactions, whether they felt prepared by the curriculum, and what support they would have liked. Read More

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December 2018

Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community.

Teach Learn Med 2018 Dec 15:1-10. Epub 2018 Dec 15.

c Department of Medicine , Uniformed Services University , Bethesda , Maryland , USA.

Phenomenon: With scholarly collaborations come questions about the order of authorship. Authorship order is an important consideration because it often used as an indicator of seniority, expertise, leadership, and scholarly productivity. As a result, authorship order factors into decisions about hiring, salary, resource allocation, and professional advancement. Read More

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December 2018

Bioacessibility of lipophilic compounds vehiculated in emulsions: choice of lipids and emulsifiers.

J Agric Food Chem 2018 Dec 17. Epub 2018 Dec 17.

Great efforts have been made to design emulsions considering the need to perform an effective encapsulation, protection, vehiculation and bioaccessibility of lipophilic compounds. This task can be achieved by manipulating the structure of the emulsion based on the choice of the processes and ingredients of the aqueous phase, interface and lipid matrix. Thus, the main focus of this manuscript is to provide insights into the use of ingredients engineering in manipulating/building emulsion structures that enhance lipophilic compounds release and bioaccessibility. Read More

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December 2018

Packaging functionally-important plasma proteins into the α-granules of human induced pluripotent stem cell-derived megakaryocytes.

J Tissue Eng Regen Med 2018 Dec 17. Epub 2018 Dec 17.

Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI.

The contents of platelet α-granules arrive via a number of pathways; some are synthesized by megakaryocytes (MKs), e.g., von Willebrand Factor (VWF), while others are endocytosed from plasma, e. Read More

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December 2018

Microbial communities in swine lungs and their association with lung lesions.

Microb Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory for Swine Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, 330045, China.

Under natural farming, environmental pathogenic microorganisms may invade and affect swine lungs, further resulting in lung lesions. However, few studies on swine lung microbiota and their potential relationship with lung lesions were reported. Here, we sampled 20 pigs from a hybrid herd raised under natural conditions; we recorded a lung-lesion phenotype and investigated lung microbial communities by sequencing the V3-V4 region of 16S rRNA gene for each individual. Read More

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December 2018

A case-control genome wide association study of substance use disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE).

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 16. Epub 2018 Dec 16.

School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia.

Genome wide association studies (GWASs) have provided insights into the molecular basis of the disorder in different population. This study presents the first GWAS of substance use disorder (SUD) in patients from the United Arab Emirates (UAE). The aim was to identify genetic association(s) that may provide insights into the molecular basis of the disorder. Read More

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December 2018

Review of future insights of Dragon's Blood in dermatology.

Dermatol Ther 2018 Nov 22:e12786. Epub 2018 Nov 22.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, North Carolina.

To assess the possible clinical implication of Dragon's Blood in dermatology, a PubMed search was conducted using the keyword "Dragon's Blood," "Croton lechleri," and more. Dragon's Blood from C. lechleri is an Amazonian medicinal plant with a characteristic red sap. Read More

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November 2018

Editorial: Medicines pricing, access and safety in Morocco.

Trop Med Int Health 2018 Dec 16. Epub 2018 Dec 16.

Department of Pharmacy, University of Huddersfield, UK.

Unregulated supply of medicines compromises quality assurance and risks patient safety. The emergence of illegal medicines trafficking in Morocco presents a major health threat, which highlights the need for region-wide alignment in policies to drive stringent regulatory enforcement and robust health systems that ensure population wide access to safe medicines. Herein, we draw on insights from a situational analysis in Morocco, as a lower middle income setting, to present access to medicines through regulated supply procedures as a vital prerequisite for quality assurance and patient safety. Read More

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December 2018

MicroRNA-205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Institute of Animal Sciences, Jilin Academy of Agricultural Sciences, Changchun, Jilin, China.

MicroRNA-205 (miR-205) is involved in various physiological and pathological processes, but its biological function in follicular atresia remains unclear. In this study, we investigated miR-205 expression in mouse granulosa cells (mGCs) and analyzed its functions in primary mGCs by performing a series of in vitro experiments. Quantitative real-time polymerase chain reaction showed that miR-205 expression was significantly higher in early atretic follicles and progressively atretic follicles than in healthy follicles. Read More

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December 2018

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics-based approach to understand the mechanism of cancer development.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Protection of telomere 1 (POT1) is one of the key components of shelterin complex, implicated in maintaining the telomere homeostasis, and thus stability of the eukaryotic genome. A large number of non-synonymous single nucleotide polymorphisms (nsSNPs) in the POT1 gene have been reported to cause varieties of human diseases, including cancer. In recent years, a number of mutations in POT1 has been markedly increased, and interpreting the effect of these large numbers of mutations to understand the mechanism of associated diseases seems impossible using experimental approaches. Read More

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December 2018

Pollen tube integrity regulation in flowering plants: insights from molecular assemblies on the pollen tube surface.

New Phytol 2018 Dec 16. Epub 2018 Dec 16.

State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing, 100871, People's Republic of China.

Unlike in animals, sperm in flowering plants are immotile and they are embraced as passive cargoes by a pollen tube which embarks on a long journey in the pistil to deliver them to the female gametophyte for fertilization. How the pollen tube switches from a rapid polarized growth towards its target to an abrupt disintegration for sperm cell release inside the female gametophyte has been puzzling. Recent studies showed that members of the Catharanthus roseus RLK1-like (CrRLK1L) receptor kinase family and their ligands, 5-kDa cysteine-rich peptides rapid alkalinization factors (RALFs), engage in an intricate balancing act involving autocrine and paracrine signaling to maintain pollen tube growth and induce timely tube rupture at the spatially confined pollen tube-female gametophyte interface. Read More

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December 2018

Parkinson's Disease in the Era of Personalised Medicine: One Size Does Not Fit All.

Drugs Aging 2018 Dec 17. Epub 2018 Dec 17.

Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallett St, Camperdown, NSW, 2050, Australia.

The concept of personalised medicine in Parkinson's disease has arrived where the implications of findings made in research are certain to have an increasing impact upon clinical practice. Disease heterogeneity in Parkinson's disease has been well described and lends itself to the construct of personalised medicine where it is hypothesised that a greater understanding of genetic and pathophysiological contributions may underpin the sub-groups described. This in turn has driven the development of potentially individualised disease-modifying therapies where, for example, we are beginning to see treatments that target patients with Parkinson's disease with specific genetic mutations. Read More

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December 2018

Universal localization transition accompanying glass formation: insights from efficient molecular dynamics simulations of diverse supercooled liquids.

Soft Matter 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemical and Biomedical Engineering, University of South Florida, Tampa, Florida 33612, USA.

The origin of the precipitous dynamic arrest known as the glass transition is a grand open question of soft condensed matter physics. It has long been suspected that this transition is driven by an onset of particle localization and associated emergence of a glassy modulus. However, progress towards an accepted understanding of glass formation has been impeded by an inability to obtain data sufficient in chemical diversity, relaxation timescales, and spatial and temporal resolution to validate or falsify proposed theories for its physics. Read More

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December 2018

Evaluation of the Leaf Essential Oil from and Its Larvicidal and Repellent Activity against Dengue Fever Vector -An Experimental and Molecular Docking Investigation.

ACS Omega 2018 Nov 16;3(11):15657-15665. Epub 2018 Nov 16.

Department of Botany and Theoretical and Computational Chemistry Laboratory, School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India.

is a mosquito vector that spreads dengue fever and yellow fever worldwide in tropical and subtropical countries. Essential oil isolated from is found to have larvicidal and repellent action against this vector. The dried leaves were subjected to hydrodistillation using a clevenger-type apparatus for 4 h. Read More

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November 2018

Stabilization of Liposomes by Perfluorinated Compounds.

ACS Omega 2018 Nov 13;3(11):15353-15360. Epub 2018 Nov 13.

Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

Perfluorinated compounds (PFCs) are emerging persistent environmental contaminants that may be toxic to animals and humans. To gain fundamental insights into the mechanism of their toxicity, the interactions of phosphocholine (PC) liposomes as model membranes were studied with three types of PFCs, including perfluorooctanoic acid, perfluorooctane sulfonate, and perfluorohexanesulfonic acid potassium salt, together with three common surfactants: sodium dodecyl sulfate (SDS), cetyltrimethylammonium bromide (CTAB), and sodium 1-heptanesulfonate (SHS). The interactions were systematically characterized by zeta potential measurement, dynamic light scattering, negative-stain transmission electron microscopy, and fluorescence spectroscopy. Read More

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November 2018

Quantitative Interrelation between Atractylenolide I, II, and III in Koidzumi Rhizomes, and Evaluation of Their Oxidative Transformation Using a Biomimetic Kinetic Model.

ACS Omega 2018 Nov 5;3(11):14833-14840. Epub 2018 Nov 5.

Department of Chemistry, The Research Institute of Natural Sciences, Sookmyung Women's University, 04310 Seoul, Republic of Korea.

Analytical methods based on ultraperformance liquid chromatography/ion-trap mass spectrometry (UPLC/ion-trap MS) were developed for quantification of atractylenolide I, II, and III in the methanol extract of rhizomes with a C column in an acidified water/acetonitrile gradient eluent in an LC system, and ion-trap MS coupled with electrospray ionization was employed under positive-ion mode. The three atractylenolides were quantified in all samples, and the content of atractylenolide I, II, and III showed a significant correlation to each other. Such high correlation was explained by the mechanistic insights into the biosynthetic pathway of atractylenoide III and I from atractylenoide II by using the biomimetic cytochrome P450 model, [Fe(tmp)](CFSO) (tmp = -tetramesitylporphyrin). Read More

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November 2018

Content analysis of 50 clinical negligence claims involving test results management systems in general practice.

BMJ Open Qual 2018 22;7(4):e000463. Epub 2018 Nov 22.

Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Background And Aims: Laboratory test results management systems are a complex safety issue in primary care settings worldwide. Related failures lead to avoidable patient harm, medicolegal action, patient complaints and additional workload to problem solve identified issues. We aimed to review and learn from 50 clinical negligence cases involving system failures related to the management of test results. Read More

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November 2018

Why Are Saccharides Dehydrated in the Presence of Electrolytes? Insights from Molecular Modeling and Thermodynamic Measurements.

ACS Cent Sci 2018 Nov 31;4(11):1531-1536. Epub 2018 Oct 31.

Laboratoire de Genie Chimique, Université de Toulouse, CNRS, INP, UPS, Toulouse, France.

The mechanisms governing the interactions of neutral polar solutes with ions in aqueous solutions are still poorly understood, despite the importance of this phenomenon in many fields (chemistry, physicochemistry, biology, food industries). In order to go further through the understanding of the molecular mechanisms governing the ions' specific effects, this paper presents a generic method dealing with the characterization and understanding of interactions between saccharides and ions in aqueous systems. For that, an original approach combining a computational technique and experimental measurements (thermodynamic properties) is proposed to explain and rationalize the relationship between the solute hydration and the physical chemistry of the ions in solution (cation/anion, charge, size, and hydration). Read More

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November 2018

Resilience and learning from insurance firms: Dataset on British long-term insurance market performance.

Data Brief 2018 Dec 24;21:2360-2366. Epub 2018 Nov 24.

Portsmouth Business School, University of Portsmouth, PO1 3DE Portsmouth, UK.

This data article revealed data about the UK long-term insurance market performance for over a decade. The data was acquired from the ABI and contains important trading results (i.e. Read More

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December 2018

Understanding mechanisms underlying the pathology of immune reconstitution inflammatory syndrome (IRIS) by using animal models.

Curr Clin Microbiol Rep 2018 Sep 22;5(3):201-209. Epub 2018 Jun 22.

Duke University School of Medicine, Department of Immunology, Durham, NC, USA.

Purpose Of Review: Despite the increasing number of clinical reports on immune reconstitution inflammatory syndrome (IRIS), mechanistic understanding of IRIS is still largely limited. The main focus of this review is to summarize animal studies, which were performed to better understand the cellular and molecular mechanisms underlying the pathology of IRIS.

Recent Findings: Three IRIS animal models have been reported. Read More

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September 2018

Reversible Restructuring of Silver Particles during Ethylene Epoxidation.

ACS Catal 2018 Dec 8;8(12):11794-11800. Epub 2018 Nov 8.

Laboratory of Inorganic Materials Chemistry, Schuit Institute of Catalysis, Eindhoven University of Technology P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

The restructuring of a silver catalyst during ethylene epoxidation under industrially relevant conditions was investigated without and with vinyl chloride (VC) promotion. During non-VC-promoted ethylene epoxidation, the silver particles grow and voids are formed at the surface and in the bulk. Electron tomography highlighted the presence of voids below the Ag surface. Read More

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December 2018