182,583 results match your criteria Insight: The Journal of the American Society of Ophthalmic Registered Nurses [Journal]


Describing How School-Based SLPs Determine Eligibility for Children with Speech Sound Disorders.

Semin Speech Lang 2019 Mar 22;40(2):105-112. Epub 2019 Feb 22.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, Ohio.

The purpose of this study was to explore how school-based speech-language pathologists (SLPs) determine eligibility for children with speech sound disorders (SSDs). Presently, there is substantial variability nationwide with respect to if or how children with SSDs receive speech therapy in public schools. We report the results of a nation-wide survey of school-based SLPs, which further underscore this variability. Read More

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http://dx.doi.org/10.1055/s-0039-1677761DOI Listing

Age differences in specific neural connections within the Default Mode Network underlie theory of mind.

Neuroimage 2019 Feb 19. Epub 2019 Feb 19.

Indiana University, Bloomington, USA.

Theory of mind (i.e., the ability to infer others' mental states) - a fundamental social cognitive ability - declines with increasing age. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.024DOI Listing
February 2019

Impact, Insight, and Innovation: Our Legacy of Learning.

Authors:
Mark S Talamonti

J Am Coll Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, NorthShore University HealthSystem, Evanston, IL. Electronic address:

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.02.041DOI Listing
February 2019

Visual attention and neural oscillations in reading and dyslexia: are they possible targets for remediation?

Neuropsychologia 2019 Feb 19. Epub 2019 Feb 19.

Visual and Cognitive Neuroscience Unit, Department of Optometry & Vision Sciences and Melbourne Neuroscience Institute, University of Melbourne, Parkville, Vic 3010, Australia. Electronic address:

After decades of finding a range of cognitive functions both in visual and phonological domains that correlate with reading performance, there are in recent years attempts to solve the causation versus correlation dilemma in finding a core deficit in developmental dyslexia (DD). Thus, longitudinal studies that aim to predict reading difficulties from studies done in pre-reading years and reading-level matched studies that try to factor out the effect due to lack of reading in DD cohorts, have helped identify two possible candidates to be added to the classical phonological suspect. One is a deficit in visuo-spatial attention that underpins our ability to selectively attend to individual objects in a cluttered world, which is fundamental in being able to identify letters and words in a text such as the one you are reading now. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.02.009DOI Listing
February 2019

Transcriptomic insight into antimicrobial peptide factors involved in the prophylactic immunity of crowded Mythimna separata larvae.

Dev Comp Immunol 2019 Feb 19. Epub 2019 Feb 19.

College of Horticulture and Plant Protection, Yangzhou University, Wenhui East Road, NO. 48, Yangzhou, Jiangsu Province, 225009, China.

Similar to pathogenic infection, a high population density alters insect prophylactic immunity. Antimicrobial peptides (AMPs) are known to play critical roles in an insect's humoral immune response to microbial infection. We applied RNA sequencing to investigate differential gene expression levels in fat body and hemocyte samples from larvae reared in high- (10 larvae per jar) and low-density (1 larva per jar) conditions; the samples exhibited density-dependent prophylaxis. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.009DOI Listing
February 2019

The Classification of Minor Gait Alterations Using Wearable Sensors and Deep Learning.

IEEE Trans Biomed Eng 2019 Feb 21. Epub 2019 Feb 21.

Objective: This paper describes how non-invasive wearable sensors can be used in combination with deep learn- ing to classify artificially induced gait alterations without the requirement for a medical professional or gait analyst to be present. This approach is motivated by the goal of diagnosing gait abnormalities on a symptom by symptom basis, irrespective of other neuromuscular movement disorders patients may be affected by. This could lead to improvements in treatment and offer a greater insight into movement disorders. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900863DOI Listing
February 2019

Overview of Leafy Greens-Related Food Safety Incidents with a California Link: 1996 to 2016.

J Food Prot 2019 Feb 21:405-414. Epub 2019 Feb 21.

2 Food and Drug Branch, California Department of Public Health, 1500 Capitol Avenue, Sacramento, California 95814.

An increase in the number of foodborne illness outbreaks associated with produce has been noted in the literature, and leafy greens have been the most common produce category associated with these outbreaks. California is the largest leafy greens producer in the United States, and many related foodborne illness incidents were traced to this state. A systematic overview of leafy greens incidents linked to California was conducted by the California Department of Public Health, Food and Drug Branch through analysis of complaints, routine surveillance sampling, disease outbreaks, and investigations covering 1996 to 2016. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-316DOI Listing
February 2019

Ab Initio Probing of the Ground State of Tetraradicals: Inattention to the Strictest Form of Hund's Rule.

J Phys Chem A 2019 Feb 22. Epub 2019 Feb 22.

The electronic structure of organic $\sigma$-type polyradical including 2,4,6-tridehydropyridine radical cation (246-TDHP) and three isomers of tetradehydrobenzene(TDHB) have been studied using a computationally robust and cost-effective second-order multireference perturbative model which provides a balanced treatment of nondynamic and dynamic contributions to the electron correlation problem in the ground or excited electronic states which are imperative for predicting structural properties (e.g., ground state multiplicity, energy gaps between high-spin and low-spin states, etc. Read More

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http://dx.doi.org/10.1021/acs.jpca.8b10514DOI Listing
February 2019

Patterning Multicolor Hybrid Perovskite Films via Top-Down Lithography.

ACS Nano 2019 Feb 22. Epub 2019 Feb 22.

Lead halide perovskites have attracted great attention due to their excellent optoelectronic properties, with great progress being made in their performance as light emitting diodes (LEDs), photodiodes, and solar cells. Demonstrating large scale, high-resolution patterning of perovskites is a key enabling step to unlock their full potential for a range of optoelectronic applications. However, the development of a successful top-down lithography fabrication procedure has so far been hampered by the incompatibility of perovskite films with the solvents used during lithographic processes. Read More

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http://dx.doi.org/10.1021/acsnano.8b09592DOI Listing
February 2019

Interactions of an Anti-sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Bioconjug Chem 2019 Feb 22. Epub 2019 Feb 22.

The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the polymerization of deoxygenated hemoglobin S (HbS) into long fibers and sickling of red blood cells (RBCs). One approach toward mitigating HbS polymerization is to pharmacologically stabilize the oxygenated (R) con-formation of HbS and thereby reduce sickling frequency and SCD pathology. GBT440 is an α subunit specific modifying agent that has recently been reported to increase HbS oxygen binding affinity and consequently delay in vitro polymerization. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00130DOI Listing
February 2019

SLAMCast: Large-Scale, Real-Time 3D Reconstruction and Streaming for Immersive Multi-Client Live Telepresence.

IEEE Trans Vis Comput Graph 2019 Feb 18. Epub 2019 Feb 18.

Real-time 3D scene reconstruction from RGB-D sensor data, as well as the exploration of such data in VR/AR settings, has seen tremendous progress in recent years. The combination of both these components into telepresence systems, however, comes with significant technical challenges. All approaches proposed so far are extremely demanding on input and output devices, compute resources and transmission bandwidth, and they do not reach the level of immediacy required for applications such as remote collaboration. Read More

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http://dx.doi.org/10.1109/TVCG.2019.2899231DOI Listing
February 2019

Fast and Robust Symmetric Image Registration Based on Distances Combining Intensity and Spatial Information.

IEEE Trans Image Process 2019 Feb 18. Epub 2019 Feb 18.

Intensity-based image registration approaches rely on similarity measures to guide the search for geometric correspondences with high affinity between images. The properties of the used measure are vital for the robustness and accuracy of the registration. In this study a symmetric, intensity interpolationfree, affine registration framework based on a combination of intensity and spatial information is proposed. Read More

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http://dx.doi.org/10.1109/TIP.2019.2899947DOI Listing
February 2019

Direct Automatic Coronary Calcium Scoring in Cardiac and Chest CT.

IEEE Trans Med Imaging 2019 Feb 18. Epub 2019 Feb 18.

Cardiovascular disease (CVD) is the global leading cause of death. A strong risk factor for CVD events is the amount of coronary artery calcium (CAC). To meet demands of the increasing interest in quantification of CAC, i. Read More

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http://dx.doi.org/10.1109/TMI.2019.2899534DOI Listing
February 2019

The impact of racial and ethnic disparities in inhaled corticosteroid adherence on healthcare expenditures in adults with asthma.

Curr Med Res Opin 2019 Feb 22. Epub 2019 Feb 22.

c Sanofi Health Economics and Value Assessment , USA.

Purpose: The purpose of this study is to determine racial and ethnic disparities with the adherence to inhaled corticosteroids (ICSs) in adults with persistent asthma, and its association with healthcare expenditures.

Methods: A retrospective, cross-sectional study using the Medical Expenditure Panel Survey (MEPS) 2013-2014 data included patients ≥18 years with persistent asthma. Median medication possession ratio (MPR) was used to dichotomize adherence levels. Read More

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http://dx.doi.org/10.1080/03007995.2019.1586221DOI Listing
February 2019

A membership categorization analysis of roles, activities and relationships in inclusive research conducted by co-researchers with intellectual disabilities.

J Appl Res Intellect Disabil 2019 Feb 22. Epub 2019 Feb 22.

Chair Disability Studies: Diversity in Participation, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands.

Background: Inclusive research is studied mainly in short-term collaborations between researchers with and without intellectual disabilities focusing on practicalities. Structural study of long-term collaborations can provide insight into different roles of inclusive researchers, thereby contributing to a collective approach.

Method: Interviews with inclusive research team members (n = 3), colleagues (n = 8), and managers (n = 2) and three group discussions within the inclusive research team were held. Read More

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http://dx.doi.org/10.1111/jar.12567DOI Listing
February 2019

Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT.

Health Technol Assess 2019 Feb;23(5):1-148

Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK.

Background: Fever accelerates host immune system control of pathogens but at a high metabolic cost. The optimal approach to fever management and the optimal temperature thresholds used for treatment in critically ill children are unknown.

Objectives: To determine the feasibility of conducting a definitive randomised controlled trial (RCT) to evaluate the clinical effectiveness and cost-effectiveness of different temperature thresholds for antipyretic management. Read More

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http://dx.doi.org/10.3310/hta23050DOI Listing
February 2019

Enhancing governance and strengthening advocacy for policy change of large Collective Impact initiatives.

Matern Child Nutr 2019 Feb;15 Suppl 2:e12728

Division of Nutritional Sciences, Cornell University, Ithaca, New York.

Nutrition issues are increasingly being addressed through global partnerships and multi-sectoral initiatives. Ensuring effective governance of these initiatives is instrumental for achieving large-scale impact. The Collective Impact (CI) approach is an insightful framework that can be used to guide and assess the effectiveness of this governance. Read More

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http://dx.doi.org/10.1111/mcn.12728DOI Listing
February 2019

Recent progress in development of molecular catalyst-based anodes for water oxidation toward artificial photosynthesis.

ChemSusChem 2019 Feb 21. Epub 2019 Feb 21.

Niigata University, Materials Science and Technology, 8050 Ikarashi-2, 950-2181, Niigata, JAPAN.

Catalytic water oxidation represents the bottleneck for developing artificial photosynthetic systems that store solar energy as renewable fuels. A variety of molecular water oxidation catalysts (WOCs) were reported over the last two decades. In view of their applications to artificial photosynthetic devices, it is essential to immobilize molecular catalysts onto surfaces of conducting/semiconducting supports for fabricating efficient and stable water oxidation anodes/photoanodes. Read More

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http://dx.doi.org/10.1002/cssc.201802795DOI Listing
February 2019

Insight into salivary gland proteomes of two polyphagous stink bugs: Nezara viridula L. and Halyomorpha halys Stål.

Proteomics 2019 Feb 21:e1800436. Epub 2019 Feb 21.

Functional and Evolutionary Entomology, Terra Research & Teaching Center, Gembloux Agro-Bio Tech, University of Liege, Gembloux, Belgium.

The invasive Brown Marmorated Stink Bug (BMSB), Halyomorpha halys Stål, and the Southern Green Stink Bugs (SGSB), Nezara viridula L., are widely distributed in Europe, even if the date of introduction and the diet differ. Saliva of Hemipteran pests plays essential roles in the interaction between insects and their host plants. Read More

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http://dx.doi.org/10.1002/pmic.201800436DOI Listing
February 2019

De-legitimising complementary medicine: framings of the Friends of Science in Medicine-CAM debate in Australian media reports.

Authors:
Monique Lewis

Sociol Health Illn 2019 Feb 21. Epub 2019 Feb 21.

School of Humanities, Languages and Social Science, Griffith University, Brisbane , Australia.

Complementary and alternative medicine (CAM) has developed into a complex and formidable commercial, sociocultural and political force in Australia, and given its influence, it is a relevant subject for scholars, health practitioners, health communicators, journalists, policy-makers, and consumers of healthcare products and services. This research will consider a relative newcomer to the claims-making space about CAM in the Australian health media-scape; the Friends of Science in Medicine (FSM), an activist group of medical practitioners, researchers, and scientists, founded in late 2011. Using content analysis supported by NVivo, I searched for articles specifically referring to FSM and measured the patterns and frequencies of media frames, intonation and sources that are featured in Australian mainstream news reports between December 2011 and April 2017. Read More

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http://dx.doi.org/10.1111/1467-9566.12865DOI Listing
February 2019

Trabecular architecture of the great ape and human femoral head.

J Anat 2019 Feb 21. Epub 2019 Feb 21.

Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK.

Studies of femoral trabecular structure have shown that the orientation and volume of bone are associated with variation in loading and could be informative about individual joint positioning during locomotion. In this study, we analyse for the first time trabecular bone patterns throughout the femoral head using a whole-epiphysis approach to investigate how potential trabecular variation in humans and great apes relates to differences in locomotor modes. Trabecular architecture was analysed using microCT scans of Pan troglodytes (n = 20), Gorilla gorilla (n = 14), Pongo sp. Read More

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http://dx.doi.org/10.1111/joa.12957DOI Listing
February 2019
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uMUC1-Targeting Magnetic Resonance Imaging of Therapeutic Response in an Orthotropic Mouse Model of Colon Cancer.

Mol Imaging Biol 2019 Feb 21. Epub 2019 Feb 21.

Precision Health Program, Department of Radiology, College of Human Medicine, Michigan State University, 775 Woodlot Dr., Rm. 3.111, East Lansing, MI, 48823, USA.

Purpose: Noninvasive assessment of chemotherapeutic response in colon cancer would tremendously aid in therapeutic intervention of cancer patients and improve outcomes. The aim of the study was to evaluate the feasibility of a noninvasive assessment of chemotherapeutic response by magnetic resonance imaging utilizing underglycosylated mucin 1 (uMUC1) tumor antigen as a biomarker of therapeutic response in a colon cancer mouse model.

Procedures: The study was performed by applying molecular imaging approach based on targeting uMUC1 with specific dual-modality imaging probe (MN-EPPT). Read More

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http://dx.doi.org/10.1007/s11307-019-01326-5DOI Listing
February 2019

Does co-transcriptional regulation of alternative splicing mediate plant stress responses?

Nucleic Acids Res 2019 Feb 22. Epub 2019 Feb 22.

School of Human and Life Sciences, Canterbury Christ Church University, Canterbury, CT1 1QU, UK.

Plants display exquisite control over gene expression to elicit appropriate responses under normal and stress conditions. Alternative splicing (AS) of pre-mRNAs, a process that generates two or more transcripts from multi-exon genes, adds another layer of regulation to fine-tune condition-specific gene expression in animals and plants. However, exactly how plants control splice isoform ratios and the timing of this regulation in response to environmental signals remains elusive. Read More

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http://dx.doi.org/10.1093/nar/gkz121DOI Listing
February 2019

Deep core photoionization of iodine in CHI and CFI molecules: how deep down does the chemical shift reach?

Phys Chem Chem Phys 2019 Feb 22. Epub 2019 Feb 22.

RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.

Hard X-ray electron spectroscopic study of iodine 1s and 2s photoionization of iodomethane (CH3I) and trifluoroiodomethane (CF3I) molecules is presented. The experiment was carried out at the SPring-8 synchrotron radiation facility in Japan. The results are analyzed with the aid of relativistic molecular and atomic calculations. Read More

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http://dx.doi.org/10.1039/c8cp07307dDOI Listing
February 2019

Total Adipose Retinol Concentrations Are Correlated with Total Liver Retinol Concentrations in Male Mongolian Gerbils, but Only Partially Explained by Chylomicron Deposition Assessed with Total α-Retinol.

Curr Dev Nutr 2019 Feb 8;3(2):nzy096. Epub 2019 Feb 8.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.

Background: Liver vitamin A (VA) concentration is the gold standard for VA status, but is not routinely accessible. Adipose tissue VA concentrations, as retinol and retinyl esters, may be correlated to liver VA. α-VA (as α-retinol) is a cleavage product of α-carotene that traces postprandial VA distribution to tissues but cannot recirculate from hepatic stores, providing insight into tissue VA sources. Read More

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http://dx.doi.org/10.1093/cdn/nzy096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377429PMC
February 2019

A mixed-modeling framework for analyzing multitask whole-brain network data.

Netw Neurosci 2019 1;3(2):307-324. Epub 2019 Feb 1.

Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, NC, USA.

The emerging area of brain network analysis considers the brain as a system, providing profound insight into links between system-level properties and health outcomes. Network science has facilitated these analyses and our understanding of how the brain is organized. While network science has catalyzed a paradigmatic shift in neuroscience, methods for statistically analyzing networks have lagged behind. Read More

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http://dx.doi.org/10.1162/netn_a_00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370463PMC
February 2019

Correlates of sun protection behaviors in racially and ethnically diverse U.S. adults.

Prev Med Rep 2019 Mar 28;13:346-353. Epub 2018 Dec 28.

University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Blockley Hall, Philadelphia, PA 19104, United States of America.

Although skin cancer incidence is highest among non-Hispanic Whites, minority populations are often diagnosed with more advanced stage disease and are more likely to experience poor outcomes. Fewer people of color do not practice primary prevention of skin cancer according to recommendations, but public health education and interventions to promote sun protection behaviors have consistently targeted non-Hispanic Whites. This study examines performance of sun protection behaviors in a multiethnic sample and whether demographic, lifestyle and psychosocial predictors of these behaviors differ by race and ethnicity. Read More

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http://dx.doi.org/10.1016/j.pmedr.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369227PMC

Proteomic and metabolomic analyses provide insight into the off-flavour of fruits from citrus trees infected with ' Liberibacter asiaticus'.

Hortic Res 2019 14;6:31. Epub 2019 Feb 14.

2Citrus Research and Education Center, University of Florida, Lake Alfred, FL 33850 USA.

Orange fruit from trees infected by ' Liberibacter asiaticus' (Las) often do not look fully mature and exhibit off-flavours described as bitter, harsh, and metallic rather than juicy and fruity. Although previous studies have been carried out to understand the effect of Las on the flavour of orange juice using metabolomic methods, the mechanisms leading to the off-flavour that occurs in Huanglongbing (HLB)-symptomatic fruit are not well understood. In this study, fruits were collected from symptomatic and healthy Valencia sweet orange () trees grafted on Swingle ( X ) rootstock. Read More

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http://dx.doi.org/10.1038/s41438-018-0109-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375920PMC
February 2019

The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B.

Authors:
Keith McCormack

Ecancermedicalscience 2018 20;12:889. Epub 2018 Dec 20.

McCormack Pharma, a division of McCormack Ltd, Stirling House, 9 Burroughs Gardens, London NW4 4AU, UK.

Following systematic scrutiny of the evidence in support of the hypothesis that the cardioprotective mechanism of action of dexrazoxane is mediated by a 'depletion' or 'downregulation' of Top2β protein levels in heart tissue, the author concludes that this hypothesis is untenable. In seeking to understand how dexrazoxane protects the heart, the outcomes of a customised association rule learning algorithm incorporating the use of antecedent surrogate variables (CEME, 2017 McCormack Pharma) reveal a previously unknown relationship between dexrazoxane and poly(ADP-ribose) (PAR) polymer. The author shows how this previously unknown relationship explains both acute and long-term cardioprotection in patients receiving anthracyclines. Read More

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http://dx.doi.org/10.3332/ecancer.2018.889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351063PMC
December 2018

Functional Coordination of the Chromatin-Remodeling Factor AtINO80 and the Histone Chaperones NRP1/2 in Inflorescence Meristem and Root Apical Meristem.

Front Plant Sci 2019 7;10:115. Epub 2019 Feb 7.

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.

Chromatin structure requires proper modulation in face of transcriptional reprogramming in the context of organism growth and development. Chromatin-remodeling factors and histone chaperones are considered to intrinsically possess abilities to remodel chromatin structure in single or in combination. Our previous study revealed the functional synergy between the Arabidopsis chromatin-remodeling factor INOSITOL AUXOTROPHY 80 (AtINO80) and the histone chaperone NAP1-RELATED PROTEIN 1 (NRP1) and NRP2 in somatic homologous recombination, one crucial pathway involved in repairing DNA double strand breaks. Read More

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http://dx.doi.org/10.3389/fpls.2019.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374632PMC
February 2019

Plant-Mediated RNAi for Controlling .

Front Plant Sci 2019 6;10:64. Epub 2019 Feb 6.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

The polyphagous mirid bug (Heteroptera: Miridae) is a serious pest of agricultural crops in China, with more than 200 species of host plants including two very important crops, maize and soybean. Currently, prevention and control of rely mainly on chemical pesticides that cause environmental as well as health related problems. Plant-mediated RNAi has proven to offer great potential for pest control in the past decade. Read More

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http://dx.doi.org/10.3389/fpls.2019.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374644PMC
February 2019

Evolutionary Relationships Between the Laccase Genes of Polyporales: Orthology-Based Classification of Laccase Isozymes and Functional Insight From .

Front Microbiol 2019 6;10:152. Epub 2019 Feb 6.

Laboratory of Molecular Aspects of Biotransformations, A. N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.

Laccase is one of the oldest known and intensively studied fungal enzymes capable of oxidizing recalcitrant lignin-resembling phenolic compounds. It is currently well established that fungal genomes almost always contain several non-allelic copies of laccase genes (laccase multigene families); nevertheless, many aspects of laccase multigenicity, for example, their precise biological functions or evolutionary relationships, are mostly unknown. Here, we present a detailed evolutionary analysis of the laccase genes (CAZy - AA1_1) from fungi of the Polyporales order. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374638PMC
February 2019

Gender Identification of Human Cortical 3-D Morphology Using Hierarchical Sparsity.

Front Hum Neurosci 2019 7;13:29. Epub 2019 Feb 7.

College of Mechatronics and Automation, National University of Defense Technology, Changsha, China.

Difference exists widely in cognition, behavior and psychopathology between males and females, while the underlying neurobiology is still unclear. As brain structure is the fundament of its function, getting insight into structural brain may help us to better understand the functional mechanism of gender difference. Previous structural studies of gender difference in Magnetic Resonance Imaging (MRI) usually focused on gray matter (GM) concentration and structural connectivity (SC), leaving cortical morphology not characterized properly. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374327PMC
February 2019

Understanding paediatric patients' attitudes toward obesity and expectations prior to entering a weight management program.

Paediatr Child Health 2019 Feb 24;24(1):e26-e32. Epub 2018 May 24.

Department of Pediatrics, McMaster University, Hamilton, Ontario.

Objective: This qualitative study explored attitudes toward weight management and knowledge of healthy, active living among paediatric patients referred to a weight management program. The objective of this study was to determine the emotional state and attitudes of patients entering into a paediatric weight management program.

Methods: Study participants (aged 7 to 17 years old) were recruited during clinic orientation. Read More

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http://dx.doi.org/10.1093/pch/pxy068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376291PMC
February 2019

Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution.

Sci Rep 2019 Feb 21;9(1):2448. Epub 2019 Feb 21.

Department of Anatomy, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, 105-8461, Japan.

The hatcing enzyme gene (HE) encodes a protease that is indispensable for the hatching process and is conserved during vertebrate evolution. During teleostean evolution, it is known that HE experienced a drastic transfiguration of gene structure, namely, losing all of its introns. However, these facts are contradiction with each other, since intron-less genes typically lose their original promoter because of duplication via mature mRNA, called retrocopy. Read More

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http://dx.doi.org/10.1038/s41598-019-38693-6DOI Listing
February 2019

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Nat Commun 2019 Feb 21;10(1):893. Epub 2019 Feb 21.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2. Read More

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http://dx.doi.org/10.1038/s41467-019-08790-1DOI Listing
February 2019

Kondo-like phonon scattering in thermoelectric clathrates.

Nat Commun 2019 Feb 21;10(1):887. Epub 2019 Feb 21.

Institute of Solid State Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040, Vienna, Austria.

Crystalline solids are generally known as excellent heat conductors, amorphous materials or glasses as thermal insulators. It has thus come as a surprise that certain crystal structures defy this paradigm. A prominent example are type-I clathrates and other materials with guest-host structures. Read More

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http://dx.doi.org/10.1038/s41467-019-08685-1DOI Listing
February 2019

Functional reconstitution of vacuolar H+-ATPase from Vo proton channel and mutant V1-ATPase provides insight into the mechanism of reversible disassembly.

J Biol Chem 2019 Feb 21. Epub 2019 Feb 21.

Biochemistry & Molecular Biology, SUNY Upstate Medical University, United States.

The vacuolar H+-ATPase (V-ATPase; V1Vo-ATPase) is an ATP-dependent proton pump that acidifies subcellular compartments in all eukaryotic organisms. V-ATPase activity is regulated by reversible disassembly into autoinhibited V1-ATPase and Vo proton channel subcomplexes, a process that is poorly understood on the molecular level. V-ATPase is a rotary motor, and recent structural analyses have revealed different rotary states for disassembled V1 and Vo, a mismatch that is likely responsible for their inability to reconstitute into holo V-ATPase in vitro. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007577DOI Listing
February 2019

Stimulation of heat shock protein 90 chaperone function through binding of a novobiocin analog KU-32.

J Biol Chem 2019 Feb 21. Epub 2019 Feb 21.

Indian Institute of Technology Delhi, India.

Heat shock protein 90 (Hsp90) is a eukaryotic chaperone responsible for the folding and functional activation of numerous client proteins, many of which are oncoproteins. Thus, Hsp90 inhibition has been intensely pursued, resulting in the development of many potential Hsp90 inhibitors, not all of which are well characterized. Hsp90 inhibitors not only abrogate its chaperone functions, but also could help us gain insight into the structure-function relationships of this chaperone. Read More

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http://dx.doi.org/10.1074/jbc.RA118.002502DOI Listing
February 2019

Biological treatments for severe asthma: A major advance in asthma care.

Authors:
William W Busse

Allergol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

Asthma is a heterogeneous disease with considerable variability noted in disease severity, patterns of airway inflammation, and achievement of disease control on current medications. An absence of disease control is most frequently noted in patients with severe asthma, and is defined as a lack of control while on high dose inhaled corticosteroids (ICS) plus a second controller medication. In part, this lack of control may relate to a diminished effect of current guideline-directed care on the existing pattern of airway inflammation in severe asthma. Read More

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http://dx.doi.org/10.1016/j.alit.2019.01.004DOI Listing
February 2019

Unique cartilage matrix-associated protein regulates fibrillin-2 expression and directly interacts with fibrillin-2 protein independent of calcium binding.

Biochem Biophys Res Commun 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, South Korea. Electronic address:

Unique cartilage matrix-associated protein (UCMA) is a secretory γ-carboxyglutamate (Gla) containing protein that is mainly expressed in the cartilage. Ucma, a downstream gene of both Runx2 and Osterix, has recently been described to promote osteoblast differentiation and matrix mineralization. However, till date, no studies have focused on the role of downstream target genes of Ucma in osteogenesis. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.128DOI Listing
February 2019

Suppressed Immune-Related Profile Rescues Abortion-Prone Fetuses: A Novel Insight Into the CBA/J × DBA/2J Mouse Model.

Reprod Sci 2019 Feb 21:1933719119828042. Epub 2019 Feb 21.

1 Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

The adverse clinical result and poor treatment outcome in recurrent spontaneous abortion (RSA) make it necessary to understand the pathogenic mechanism. The mating combination CBA/J × DBA/2 has been widely used as an abortion-prone model compared to DBA/2-mated CBA/J mice. Here, we used RNA-seq to get a comprehensive catalogue of genes differentially expressed between survival placenta in abortion-prone model and control. Read More

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http://dx.doi.org/10.1177/1933719119828042DOI Listing
February 2019

Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820402

1 Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood disease affecting 0.2%-2% of the global population. To gain insight into the pathophysiology of ME/CFS in New Zealand, we examined the transcriptomes of peripheral blood mononuclear cells by RNA-seq analysis in a small well-characterized patient group (10 patients), with age/gender-matched healthy controls (10 control subjects). Read More

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http://dx.doi.org/10.1177/2058738418820402DOI Listing
February 2019

Insight into the B3Transcription Factor Superfamily and Expression Profiling of Genes in Axillary Buds after Topping in Tobacco(.).

Genes (Basel) 2019 Feb 20;10(2). Epub 2019 Feb 20.

Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.

Members of the plant-specific B3 transcription factor superfamily play important roles in various growth and developmental processes in plants. Even though there are many valuable studies on genes in other species, little is known about the B3 superfamily in tobacco. We identified 114 B3 proteins from tobacco using comparative genome analysis. Read More

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http://dx.doi.org/10.3390/genes10020164DOI Listing
February 2019

A Deliberate Choice? Exploring the Decision to Switch from Cigarettes to E-Cigarettes.

Int J Environ Res Public Health 2019 Feb 20;16(4). Epub 2019 Feb 20.

Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, the Netherlands.

E-cigarettes are increasingly popular among both cigarette smokers and non-users. Although smoking cessation yields the most individual and population health benefits, switching to exclusive e-cigarette use offers some individual health benefits for cigarette smokers. However, e-cigarette use is not harmless, and its use among non-cigarette smokers should be prevented. Read More

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http://dx.doi.org/10.3390/ijerph16040624DOI Listing
February 2019

Complexities of Type I Interferon Biology: Lessons from LCMV.

Viruses 2019 Feb 20;11(2). Epub 2019 Feb 20.

School of Life and Environmental Sciences, the Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, and the Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.

Over the past decades, infection of mice with lymphocytic choriomeningitis virus (LCMV) has provided an invaluable insight into our understanding of immune responses to viruses. In particular, this model has clarified the central roles that type I interferons play in initiating and regulating host responses. The use of different strains of LCMV and routes of infection has allowed us to understand how type I interferons are critical in controlling virus replication and fostering effective antiviral immunity, but also how they promote virus persistence and functional exhaustion of the immune response. Read More

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http://dx.doi.org/10.3390/v11020172DOI Listing
February 2019

Untargeted and Targeted Metabolomics and Tryptophan Decarboxylase In Vivo Characterization Provide Novel Insight on the Development of Kiwifruits ().

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.

Kiwifruit ( cv. Hayward) is a commercially important crop with highly nutritional green fleshy fruits. The post-harvest maturation of the fruits is well characterized, but little is known about the metabolic changes that occur during fruit development. Read More

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http://dx.doi.org/10.3390/ijms20040897DOI Listing
February 2019

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Infection.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

College of Agriculture, Ningxia University, Xixia District, Yinchuan 750021, China.

Cyclic GMP-AMP synthase (cGAS) is an important cytosolic DNA sensor that plays a crucial role in triggering STING-dependent signal and inducing type I interferons (IFNs). cGAS is important for intracellular bacterial recognition and innate immune responses. However, the regulating effect of the cGAS pathway for bone marrow-derived dendritic cells (BMDCs) during () infection is still unknown. Read More

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http://dx.doi.org/10.3390/ijms20040895DOI Listing
February 2019

DNA methylation-regulated and tumor-suppressive roles of miR-487b in colorectal cancer via targeting MYC, SUZ12, and KRAS.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.

Human colorectal cancer (CRC), characterized by its high morbidity and lethality, seriously threatens human health and lives. MicroRNA-487b (miR-487b) is currently reported to be aberrantly expressed in several tumors, but the detailed functions and underlying mechanisms of miR-487b in CRC remain unclear. Here, we found that miR-487b is downregulated in CRC cell lines and is markedly decreased in tumor specimens derived from CRC patients. Read More

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http://dx.doi.org/10.1002/cam4.2032DOI Listing
February 2019

Highly selective, high capacity separation of o-xylene from C8 aromatics by a switching adsorbent layered material.

Angew Chem Int Ed Engl 2019 Feb 21. Epub 2019 Feb 21.

IRELAND.

Adsorbent materials that exhibit high selectivity without sacrificing adsorption capacity can significantly reduce energy costs for industrial separation/purification processes and thus facilitate a transition away from energy-intensive processes such as conventional distillation. Purification of the C8 aromatics (xylenes and ethylbenzene) is particularly challenging because of their similar physical properties. It is also relevant because of their industrial utility. Read More

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http://dx.doi.org/10.1002/anie.201901198DOI Listing
February 2019