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PLoS One 2022 26;17(5):e0268801. Epub 2022 May 26.

Faculty of Biological Sciences, Department of Zoology, Kohat University of Science and Technology, Khyber Pakhtunkhwa, Pakistan.

Background: Cutaneous leishmaniasis is a neglected tropical disease caused by Leishmania spp. and transmitted by female sandflies. Terrorism and counter-insurgency military operations in Federally Administered Tribal Areas (FATA) lead to a large-scale migration of internally displaced persons (IDPs) in Khyber Pakhtunkhwa and thus, new outbreaks of several infectious diseases such as cutaneous leishmaniasis occurred. Read More

Colloids Surf B Biointerfaces 2022 May 13;216:112564. Epub 2022 May 13.

Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials, University of Sorocaba (UNISO), Sorocaba, SP, Brazil. Electronic address:

After the latest dengue and Zika outbreaks, the fight against mosquito vectors has become an emerging area of research. One tool for this combat is repellents; however, these products are composed of different toxic agents. Botanical compounds with repellent potential are an alternative; however these compounds are highly volatile. Read More

PLoS One 2022 23;17(5):e0267987. Epub 2022 May 23.

Department of Stored Product Pests, Plant Protection Institute, Agriculture Research Center (ARC), Sabahia, Alexandria, Egypt.

Cowpea (Vigna unguiculata) is an important legume which is consumed globally for protein intake, particularly in Asian states. It is a well-known source of dietary fiber, protein, minerals, and vitamins. The cowpea grains are stored after harvest and used till the next harvest. Read More

Pest Manag Sci 2022 May 21. Epub 2022 May 21.

Department of Entomology, Institute of Plant Protection, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel.

Background: Push-pull with semiochemicals in pest management uses repellents to reduce response of pests to food-mate resources (push) and attractive traps to reduce populations (pull). Simulation models of push-pull can aid understanding of plant-insect interactions in nature and suggest hypotheses for field tests that improve management. A previous model indicated advantages of push-pull for controlling ambrosia beetle, Euwallacea fornicatus, pest of avocado trees. Read More

J Am Mosq Control Assoc 2022 Jun;38(2):99-103

As part of an arbovirus vector control strategy, chemical control continues to be a mainstay in mitigating the burden of disease. The current arsenal of chemicals used for this purpose, however, are becoming challenged rapidly because of issues of insecticide resistance and environmental pressure. Newer, environmentally friendly actives are of interest to supplement aging chemistries; therefore efforts to screen compounds for insecticidal activity are warranted. Read More

J Agric Food Chem 2022 May 16;70(20):5982-5992. Epub 2022 May 16.

College of Plant Protection, Shanxi Agricultural University, Taigu 030801, PR China.

The diamondback moth (DBM), (Lepidoptera: Plutellidae), is a notorious cruciferous vegetable pest globally. Mechanically damaged geranium () can strongly repel DBM, but specific plant bioactive compounds responsible for such effects have not been identified. The headspace volatiles from wounded geranium were analyzed using gas chromatography-electroantennographic detection and gas chromatography-mass spectrometry. Read More

Molecules 2022 May 3;27(9). Epub 2022 May 3.

Laboratory of Applied Organic Chemistry, Faculty of Sciences and Techniques, University Sidi Mohammed Ben Abdellah, B.P. 2202, Fes 30000, Morocco.

To ensure the better production and sustainable management of natural resources, a chemometric investigation was conducted to examine the effect of cooperative and harvesting periods on the crop yields and chemical compositions of Spenn essential oils in the Oriental region of Morocco. The samples were collected from three cooperatives over nine time periods from January 2018 to April 2019. The chemical composition of Spenn essential oils was analyzed by gas chromatography coupled with mass spectrometry. Read More

Molecules 2022 Apr 22;27(9). Epub 2022 Apr 22.

Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Korea.

Background: () is known to exhibit a beneficial effect for anti-inflammatory, anti-oxidant, and anti-hyperlipidemic effects. However, no sufficient research data are available on the cardiovascular effect of . Thus, in this study, we investigate whether extract has direct effects on vascular reactivity. Read More

Int J Mol Sci 2022 May 2;23(9). Epub 2022 May 2.

State Key Laboratory of Silkworm Genome Biology, Medical Research Institute, Southwest University, Chongqing 400715, China.

Colon cancer (CC) is one of the major causes of cancer death in humans. Despite recent advances in the management of CC, the prognosis is still poor and a new strategy for effective therapy is imperative. Deoxyelephantopin (DET), extracted from an important medicinal plant, L. Read More

Carbohydr Polym 2022 Aug 6;290:119466. Epub 2022 Apr 6.

Dept. of Textile and Fibre Engineering, Indian Institute of Technology, Delhi, India. Electronic address:

With the increasing population of mosquitoes due to urbanisation, requirement for effective mosquito repellent gadgets is rising. To guarantee the security from mosquitoes, dire need is felt to build productive innovations. In the current work, a carbohydrate-based textile fibre was functionalised for imparting colour, mosquito repellency, antibacterial activity and UV protection using a novel polymeric dye. Read More

PLoS One 2022 12;17(5):e0268347. Epub 2022 May 12.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

1,8-Cineole is a naturally occurring compound found in essential oils of different plants and has well-known anti-inflammatory and antimicrobial activities. In the present work, we aimed to investigate its potential antimalarial effect, using the following experimental models: (1) the erythrocytic cycle of Plasmodium falciparum; (2) an adhesion assay using brain microvascular endothelial cells; and (3) an experimental cerebral malaria animal model induced by Plasmodium berghei ANKA infection in susceptible mice. Using the erythrocytic cycle of Plasmodium falciparum, we characterized the schizonticidal effect of 1,8-cineole. Read More

Biosens Bioelectron 2022 Aug 3;210:114337. Epub 2022 May 3.

Department of Chemistry, Technical University of Denmark, Kongens Lyngby, 2800, Denmark. Electronic address:

Direct electron transfer (DET) of enzymes on electrode surfaces is highly desirable both for fundamental mechanistic studies and to achieve membrane- and mediator-less bioenergy harvesting. In this report, we describe the preparation and comprehensive structural and electrochemical characterization of a three-dimensional (3D) graphene-based carbon electrode, onto which the two-domain redox enzyme Myriococcum thermophilum cellobiose dehydrogenase (MtCDH) is immobilized. The electrode is prepared by an entirely novel method, which combines in a single step electrochemical reduction of graphene oxide (GO) and simultaneous electrodeposition of positively charged polyethylenimine (PEI), resulting in a well dispersed MtCDH surface. Read More

Parasit Vectors 2022 May 10;15(1):134. Epub 2022 May 10.

Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Background: There are several screening tools for detecting Leishmania infantum infection in dogs and various preventive measures to protect against it. Some studies have investigated them, but not many have described their current use. The aim of this study was to investigate which preventive measures and serological screening tools for L. Read More

SAR QSAR Environ Res 2022 Apr;33(4):239-257

SPO, Univ Montpellier, INRAE, Institut Agro, Montpellier, France.

Use of protective clothing is a simple and efficient way to reduce the contacts with mosquitoes and consequently the probability of transmission of diseases spread by them. This mechanical barrier can be enhanced by the application of repellents. Unfortunately the number of available repellents is limited. Read More

BMC Complement Med Ther 2022 May 4;22(1):122. Epub 2022 May 4.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Toxoplasmosis is caused by an intracellular zoonotic protozoan, Toxoplasma gondii, which could be lethal in immunocompromised patients. This study aimed to synthesize Neem oil-loaded solid lipid nanoparticles (NeO-SLNs) and to evaluate the anti-Toxoplasma activity of this component.

Methods: The NeO-SLNs were constructed using double emulsification method, and their shape and size distribution were evaluated using transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. Read More

Arch Microbiol 2022 May 4;204(6):295. Epub 2022 May 4.

Department of Parasitology, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.

Oral candidiasis is a fungal infection caused mainly by Candida albicans and it is a major problem among hematologic malignancy patients. Biofilm formation is an attributable factor to both virulence and drug resistance of Candida species. The aim of the study was to evaluate the biofilm-producing ability of oral C. Read More

J Breath Res 2022 May 26;16(3). Epub 2022 May 26.

Centre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, United Kingdom.

Theseeks to inform the standardisation of breath analysis methods. Fivewith gas chromatography-ion mobility spectrometry (GC-IMS), operating in the positive mode with a tritiumH 5.68 keV, 370 MBq ionisation source, were undertaken to provide benchmarkdata for this technique, to support its use in breath-testing, analysis, and research. Read More

Ecotoxicol Environ Saf 2022 Jun 25;237:113558. Epub 2022 Apr 25.

College of Animal Science, Tarim University, Alar, Xinjiang Uygur Autonomous Region 843300, PR China; Key Laboratory of Tarim Animal Husbandry Technology Corps, Tarim University, Alar, Xinjiang Uygur Autonomous Region 843300, PR China. Electronic address:

Bisphenol A (BPA) is an endocrine disruptor, that can cause immune dysfunction. Cineole (CIN) has that effect of regulating immune function and resist oxidation. Neutrophil extracellular traps (NETs) are one of the ways to resist pathogen invasion. Read More

J Med Entomol 2022 Apr 28. Epub 2022 Apr 28.

Centro de Investigaciones de Plagas e Insecticidas (CONICET-UNIDEF), Juan Bautista de Lasalle, 4397 (B1603ALO), Villa Martelli, Buenos Aires, Argentina.

Human head lice Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae) are ectoparasites that cause pediculosis, a global scale disease mainly found in school-age children. Previous works from our laboratory found nonanal, sulcatone, and geranylacetone as the main human scalp volatile components, and individually evaluated their attraction to head lice using an olfactometer. In this work, we compared how their blends at different concentrations attract head lice, and how their blended effect compares to the effect of isolated compounds. Read More

Commun Biol 2022 04 26;5(1):390. Epub 2022 Apr 26.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju, 61005, Republic of Korea.

Controlling the orientation of redox enzymes on electrode surfaces is essential in the development of direct electron transfer (DET)-based bioelectrocatalytic systems. The electron transfer (ET) distance varies according to the enzyme orientation when immobilized on an electrode surface, which influences the interfacial ET rate. We report control of the orientation of carbon monoxide dehydrogenase (CODH) as a model enzyme through the fusion of gold-binding peptide (gbp) at either the N- or the C-terminus, and at both termini to strengthen the binding interactions between the fusion enzyme and the gold surface. Read More

Reprod Biol Endocrinol 2022 Apr 22;20(1):71. Epub 2022 Apr 22.

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.

Background: Singleton pregnancy is encouraged to reduce pregnancy complications. In addition to single embryo transfer (SET), selective and spontaneous fetal reduction (SEFR and SPFR) can also achieve singleton pregnancies. After SEFR or SPFR, an inanimate fetus remains in the uterus. Read More

Molecules 2022 Apr 14;27(8). Epub 2022 Apr 14.

Laboratório de Planejamento e Desenvolvimento de Fármacos, Federal University of Pará, Augusto Correa Street, w/n, Guamá, Belém 66075-110, Brazil.

Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alternatives to conventional synthetic repellents due to their interesting residual protection and low toxicity to the environment. Read More

Proc Natl Acad Sci U S A 2022 May 22;119(18):e2118152119. Epub 2022 Apr 22.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Significance Rational control of arthropod pests is important for animal and human health as well as biodiversity preservation. As an alternative to synthetic chemical pesticides, natural repellents represent an ecological method of pest control. Through an exceptional gene library screening in scorpions, we here uncover a transient receptor potential ion channel as the chemosensory sensor for plant-derived repellents. Read More

J Ethnopharmacol 2022 Jul 18;293:115284. Epub 2022 Apr 18.

Universidade de Brasília, Laboratório de Farmacognosia, Campus Universitário Darcy Ribeiro, 70910-900, Brasília, DF, Brazil. Electronic address:

Ethnopharmacological Relevance: Vector-borne diseases represent a huge global burden impacting health systems. Aedes aegypti is the main vector of arboviral diseases including dengue, Zika, chikungunya and urban yellow fever in both tropical and subtropical areas. Ethnopharmacological investigations provide potential avenues for developing new vector control strategies. Read More

J Toxicol Environ Health A 2022 Jul 18;85(14):591-602. Epub 2022 Apr 18.

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University,Tianjin, HE, China.

is one of the most harmful storage pests in the world. The aim of this study was to determine the chemical composition, repellent, and contact activities of Moutan cortex essential oil against this insect pest. In addition, the effects of Moutan cortex were examined on the expressions of three major detoxifying enzyme genes in . Read More

Biochem Biophys Res Commun 2022 06 8;609:156-162. Epub 2022 Apr 8.

Department of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA. Electronic address:

The insect repellent methyl salicylate elicits excitatory responses upon interaction with CquiOR32, an odorant receptor (OR) from the southern house mosquito, Culex quinquefasciatus. By contrast, eucalyptol binds to CquiOR32 to generate electrophysiological and behavioral inhibitory responses. In an attempt to identify CquiOR32 variants displaying more robust inhibitory responses for more accurate current-voltage analysis, we sequenced 31 CquiOR32 clones. Read More

Braz J Biol 2022 8;84:e252990. Epub 2022 Apr 8.

Universidade Comunitária da Região de Chapecó - UNOCHAPECO, Programa de Pós-graduação em Ciências Ambientais, Chapecó, SC, Brasil.

Corn crop, due to its easy adaptation to the most diverse agroecosystems, spreads throughout the different regions of the world, making it one of the most important agricultural crops. In this crop, pest insects stand out for causing losses both in the field and in warehouses. The application of essential oils can be an important technique to be investigated in the management of insects due to its known insecticidal activity and low risk to the environment. Read More

Molecules 2022 Mar 26;27(7). Epub 2022 Mar 26.

Department of Analytical Chemistry, University of Opole, 45-052 Opole, Poland.

New cultivars of lavender adapted to arid steppe conditions were developed by the Institute of Rice of Ukrainian National Academy of Agrarian Sciences (NAAS). This work is a part of the characterization process of the new cultivars. The chemical composition of the essential oil of the seven new and eight new cultivars was investigated and compared. Read More

MMW Fortschr Med 2022 04;164(7):62

Springer Medizin, München, Germany.

Rev Environ Health 2022 Apr 8. Epub 2022 Apr 8.

Department of Environmental Health Engineering, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Over the past few decades, phthalate esters (PAEs) used as additives to improve the persistence and flexibility of polymeric materials. They are also used in cosmetics, insect repellents, and propellants, and their continuous input into drinking waters has constituted a serious risk to human health and the environment. DBPs are compounds classified as hazardous substances and have teratogenic properties. Read More