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    Botanical essential oils and uses as mosquitocides and repellents against dengue.
    Environ Int 2018 Feb 13;113:214-230. Epub 2018 Feb 13.
    United States Department of Agriculture, Agricultural Research Service, U.S. Horticultural Research Laboratory, 2001 South Rock Road, Fort Pierce, FL 34945, USA.
    Plants naturally produce bioactive compounds along with many secondary metabolites which serve as defensive chemical against herbivorers including insect pests. One group of these phytochemicals are the 'Essential Oils' (EO's), which possess an extensive range of biological activity especially insecticidal and insect repellents. This review provides a comprehensive viewpoint on potential modes of action of biosafety plant derived Essential Oils (EO's) along with their principal chemical derivatives against larvae and adult mosquito vectors of dengue virus. Read More

    Urinary concentrations of benzophenone-type ultra violet light filters and reproductive parameters in young men.
    Int J Hyg Environ Health 2018 Feb 9. Epub 2018 Feb 9.
    Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, 30100 Murcia, Spain; Health Research Methodology Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 El Palmar, Murcia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Preventive Medicine, "Virgen de la Arrixaca" University Clinical Hospital, 30120 El Palmar, Murcia, Spain.
    Background: Benzophenone (BP)-type ultraviolet (UV) light filters are chemicals frequently added to personal care products, insect repellents, sunscreens, and beverage and food packaging to diminish the harmful effects of UV sunlight on human skin or foodstuffs. BP-type UV filters have shown negative effects on male reproduction function in in vitro and animal models, but human epidemiologic studies are limited. The goal of this study was to examine associations between urinary concentrations of BP-type UV filters and semen quality and reproductive hormone levels. Read More

    Deltamethrin-resistant German Cockroaches Are Less Sensitive to the Insect Repellents DEET and IR3535 than Non-resistant Individuals.
    J Econ Entomol 2018 Feb 5. Epub 2018 Feb 5.
    UNIDEF-CITEDEF-CONICET-CIPEIN, J.B. de La Salle,Villa Martelli, Buenos Aires, Argentina.
    The German cockroach, Blattella germanica (L.) (Blattodea: Blattellidae), is a serious worldwide pest with a considerable economical and sanitary impact. It is mainly controlled by the application of synthetic insecticides, but repeated use of these substances has promoted the appearance of resistance in cockroach populations throughout the world. Read More

    Trends in insect repellent formulations: a review.
    Int J Pharm 2018 Feb 2. Epub 2018 Feb 2.
    Federal University of Rio de Janeiro, Faculty of Pharmacy, Department of Medicines, Laboratório de Desenvolvimento Galênico (LADEG), Carlos Chagas Filho Avenue, Ilha do Fundão, Rio de Janeiro 21941-590, Brazil.
    The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn). The most used repellents are DEET, IR3535 (Ethyl Butylacetylaminopropionate) (EB), Icaridin (Picaridin) and essential oils, each of them presenting advantages and disadvantages. Read More

    Sustainable manufacture of insect repellents derived from Nepeta cataria.
    Sci Rep 2018 Feb 2;8(1):2235. Epub 2018 Feb 2.
    Département de Génie Chimique, École Polytechnique de Montréal, 2900, boul. Édouard-Montpetit, H3C 3A7, Montréal, QC, Canada.
    Malaria devastates sub-Saharan Africa; the World Health Organization (WHO) estimates that 212 million people contract malaria annually and that the plasmodium virus will kill 419 000 in 2017. The disease affects rural populations who have the least economic means to fight it. Impregnated mosquito nets have reduced the mortality rate but the Anopheles mosquitoes are changing their feeding patterns and have become more active at dusk and early morning rather than after 22h00 as an adaptation to the nets. Read More

    Determining Exposure Factors of Anti-Fogging, Dye, Disinfectant, Repellent, and Preservative Products in Korea.
    Int J Environ Res Public Health 2018 Jan 30;15(2). Epub 2018 Jan 30.
    Division of Risk Assessment, National Institute of Environmental Research, Hwangyeong-ro 42, Seo-gu, Incheon 22689, Korea.
    Reliable exposure factors are essential to determine health risks posed by chemicals in consumer products. We analyzed five risk-concerned product categories (anti-fogging, dye, disinfectant, repellent, and preservative products) for 13 products (three car anti-fogging products, a lens anti-fogging product, two car dye products, two drain disinfectants, an air conditioner disinfectant, a chlorine-based disinfectant, a fabric repellent, an insect repellent for food, and a wood preservative) considered to be of high risk in order to determine exposure factors via web surveys and estimation of amount of product. Among the 3000 participants (1482 (49%) men) aged ≥19 years, drain disinfectants were used most frequently (38. Read More

    Zein Nanoparticles as Eco-Friendly Carrier Systems for Botanical Repellents Aiming Sustainable Agriculture.
    J Agric Food Chem 2018 Feb 1;66(6):1330-1340. Epub 2018 Feb 1.
    Institute of Science and Technology, São Paulo State University (UNESP) , Sorocaba, São Paulo 18087-180, Brazil.
    Botanical repellents represent one of the main ways of reducing the use of synthetic pesticides and the contamination of soil and hydric resources. However, the poor stability and rapid degradation of these compounds in the environment hinder their effective application in the field. Zein nanoparticles can be used as eco-friendly carrier systems to protect these substances against premature degradation, provide desirable release characteristics, and reduce toxicity in the environment and to humans. Read More

    A Pilot Qualitative Investigation of Stakeholders' Experiences and Opinions of Equine Insect Bite Hypersensitivity in England.
    Vet Sci 2018 Jan 9;5(1). Epub 2018 Jan 9.
    Department of Animal Production, Welfare and Veterinary Sciences, Harper Adams University, Newport, Shropshire TF10 8NB, UK.
    Equine insect bite hypersensitivity (IBH), commonly known as sweet itch or summer eczema, is a frustrating recurrent skin disease in the equine industry involving an immune reaction to the bites ofspp. midges. To investigate the impact of IBH in the field, an exploratory pilot study was conducted with equine stakeholders in one region of central England. Read More

    DEET as a feeding deterrent.
    PLoS One 2017 14;12(12):e0189243. Epub 2017 Dec 14.
    Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United States of America.
    The insect repellent N,N-diethyl-3-methylbenzamide (DEET), is a multimodal compound that acts as a spatial repellent as well as an irritant (contact repellent), thus being perceived by the insect's olfactory and gustatory systems as an odorant and a tastant, respectively. Soon after DEET was developed, almost 6 decades ago, it was reported that it reduced mosquito feeding on blood mixed with this repellent. It is now known that the mosquito proboscis senses contact repellents with the tips (labella) of the labium, which remain in direct contact with the outer layers of the skin, while the stylets, including the feeding deterrent sensor (labrum), penetrate the skin. Read More

    Neurotoxic Effects of Linalool and β-Pinene on Tribolium castaneum Herbst.
    Molecules 2017 11 24;22(12). Epub 2017 Nov 24.
    Environmental and Computational Chemistry Group, Zaragocilla Campus, School of Pharmaceutical Sciences, University of Cartagena, Cartagena 130016, Bolivar, Colombia
    Effective, ethical pest control requires the use of chemicals that are highly specific, safe, and ecofriendly. Linalool and β-pinene occur naturally as major constituents of the essential oils of many plant species distributed throughout the world, and thus meet these requirements. These monoterpenes were tested as repellents against, using the area preference method, after four hours of exposure and the effect transcriptional of genes associated with neurotransmission. Read More

    Essential oils and their components as an alternative in the control of mosquito vectors of disease.
    Biomedica 2017 Mar 29;37(0):224-243. Epub 2017 Mar 29.
    Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
    More than half of the human population is exposed to mosquito-borne infections. Climate change and the emergence of strains resistant to traditionally used insecticides have motivated the search of new agents for mosquito population control. Essential oils have been effective repellents and larvicidal agents. Read More

    Characterizing pollutant emissions from mosquito repellents incenses and implications in risk assessment of human health.
    Chemosphere 2018 Jan 22;191:962-970. Epub 2017 Oct 22.
    Shanghai Research Institute of Building Sciences Group, Shanghai, 201108, China. Electronic address:
    Mosquito-repellent incense is one of the most popular products used for dispelling mosquitos during summer in China. It releases large amounts of particulate and gaseous pollutants which constitute a potential hazard to human health. We conducted chamber experiment to characterize major pollutants from three types of mosquito-repellent incenses, further assessed the size-fractionated deposition in human respiratory system, and evaluated the indoor removing efficiency by fresh air. Read More

    Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach.
    Parasit Vectors 2017 Nov 9;10(Suppl 2):525. Epub 2017 Nov 9.
    TRS Labs, Inc., 215 Paradise Boulevard, Athens, GA, 30607, USA.
    Background: This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Interceptor®, Virbac) on transmission of heartworm L3 from mosquitoes to dogs and subsequent development of worms in treated dogs exposed to infected mosquitoes.

    Methods: Thirty-two beagle dogs were allocated to four groups of eight: Group 1, untreated controls; Group 2, treated topically with DPP on Day 0; Group 3, treated orally with MBO on Day 51; and Group 4, treated with DPP on Day 0 and MBO on Day 51. Dogs were exposed under sedation for 1 h to Dirofilaria immitis (JYD-34)-infected Aedes aegypti on Days 21 and 28. Read More

    Toxic effects of Solanum xanthocarpum Sch &Wendle against Helicoverpa armigera (Hub.), Culex quinquefasciatus (Say.) and Eisenia fetida (Savigny, 1826).
    Environ Sci Pollut Res Int 2018 Jan 15;25(3):2774-2782. Epub 2017 Nov 15.
    Entomology Research Institute, Loyola College, Chennai, 600 034, Tamil Nadu, India.
    Many commercially available agro and household chemicals are used as pesticides, repellents, and growth inhibitors against insect pests. The repeated uses of these chemicals against insect pests have caused the development of resistance in them; they also cause ill effects on nontarget organisms. The present study was aimed to evaluate the antifeedant, larvicidal, pupicidal, and biochemical effects of the solvent extracts of Solanum xanthocarpum against third instar larvae of Helicoverpa armigera. Read More

    Seasonal Terpene Variation in Needles of Pinus radiata (Pinales: Pinaceae) Trees Attacked by Tomicus piniperda (Coleoptera: Scolytinae) and the Effect of Limonene on Beetle Aggregation.
    J Insect Sci 2017 Sep;17(5)
    Université catholique de Louvain, ELIB, Earth and Life Institute, Croix du Sud 4-5, 1348 Louvain, Belgium.
    Concentrations of four monoterpenes were determined in needles of Pinus radiata (D.Don) (Pinales: Pinaceae) trees that were attacked or nonattacked by Tomicus piniperda (L.) (Coleoptera: Scolytinae). Read More

    Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center.
    Hum Reprod 2017 Dec;32(12):2532-2539
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA.
    Study Question: Are specific gravity (SG)-adjusted urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA) associated with semen parameters among men attending an academic fertility center?

    Summary Answer: Our study did not demonstrate any association between SG-adjusted urinary DCBA concentrations and semen parameters among men attending an academic fertility center.

    What Is Known Already: N,N-Diethyl-m-toluamide (DEET) is the most common active ingredient in consumer insect repellents. The recent rise in public health concerns regarding mosquito-borne diseases such as Zika, have led to an increased use of DEET insect repellents, especially among couples planning pregnancy. Read More

    Protecting cows in small holder farms in East Africa from tsetse flies by mimicking the odor profile of a non-host bovid.
    PLoS Negl Trop Dis 2017 Oct 17;11(10):e0005977. Epub 2017 Oct 17.
    International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.
    Background: For the first time, differential attraction of pathogen vectors to vertebrate animals is investigated for novel repellents which when applied to preferred host animals turn them into non-hosts thereby providing a new paradigm for innovative vector control. For effectively controlling tsetse flies (Glossina spp.), vectors of African trypanosomosis, causing nagana, repellents more powerful than plant derived, from a non-host animal the waterbuck, Kobus ellipsiprymnus defassa, have recently been identified. Read More

    Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.
    Biochim Biophys Acta 2018 Jan 13;1862(1):40-50. Epub 2017 Oct 13.
    Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA; Center for Molecular Medicine, Old Dominion University, Norfolk, VA, USA. Electronic address:
    Trace elements such as copper and cobalt have been associated with virus-host interactions. However, studies to show the effect of conjugation of copper(II) or cobalt(III) metal centers to thiosemicarbazone ligand(s) derived from either food additives or mosquito repellent such as 2-acetylethiazole or citral, respectively, on Zika virus (ZIKV) or dengue virus (serotype 2; DENV2) infections have not been explored. In this study, we show that four compounds comprising of thiosemicarbazone ligand derived from 2-acetylethiazole viz. Read More

    Evaluation of the Constituents of Vetiver Oil Against Anopheles minimus (Diptera: Culicidae), a Malaria Vector in Thailand.
    J Med Entomol 2018 Jan;55(1):193-199
    Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.
    The development of resistance by mosquitoes to current synthetic compounds has resulted in reduced effectiveness of prevention and control methods worldwide. An alternative nonchemical based control tools are needed to be evaluated particularly plant-derived essential oils. Several components of vetiver oil have been documented as insect repellents. Read More

    Adsorption and desorption of phthalic acid esters on graphene oxide and reduced graphene oxide as affected by humic acid.
    Environ Pollut 2018 Jan 5;232:505-513. Epub 2017 Oct 5.
    Department of Environmental Science, Zhejiang University, Hangzhou 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China. Electronic address:
    The implications of humic acid (HA) regarding surface properties of graphene materials and their interactions with phthalic acid esters (PAEs) are not vivid. We report the role of HA on graphene oxide (GO) and reduced graphene oxide (RGO) for sorption-desorption behavior of PAEs. Besides higher surface area and pore volume, the hydrophobic π-conjugated carbon atoms on RGO ensured prominent adsorption capacity towards PAEs in comparison to hydrophilic GO, highlighting the hydrophobic effect. Read More

    Robust Manipulations of Pest Insect Behavior Using Repellents and Practical Application for Integrated Pest Management.
    Environ Entomol 2017 10;46(5):1041-1050
    Department of Entomology, Cornell University, 630 W. North St., Geneva, NY 14456.
    In agricultural settings, examples of effective control strategies using repellent chemicals in integrated pest management (IPM) are relatively scarce compared to those using attractants. This may be partly due to a poor understanding of how repellents affect insect behavior once they are deployed. Here we attempt to identify potential hallmarks of repellent stimuli that are robust enough for practical use in the field. Read More

    Neem oil nanoemulsions: characterisation and antioxidant activity.
    J Enzyme Inhib Med Chem 2017 Dec;32(1):1265-1273
    b Dipartimento di Chimica e Tecnologie del Farmaco , " Sapienza" University of Rome , Rome , Italy.
    The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Read More

    3-Methylcyclohex-2-en-1-one for area and individual tree protection against spruce beetle (Coleoptera: Curculionidae: Scolytinae) attack in the southern Rocky Mountains.
    J Econ Entomol 2017 Oct;110(5):2140-2148
    US-Forest Service, Rocky Mountain Research Station, 240 West Prospect Street, Fort Collins, CO 80526.
    We tested 3-methylcyclohex-2-en-1-one (MCH) and an Acer kairomone blend (AKB) as repellent semiochemicals for area and single tree protection to prevent spruce beetle (Dendroctonus rufipennis Kirby) attacks at locations in Utah and New Mexico. In the area protection study, we compared host infestation rates of MCH applications at three densities (20, 40, and 80 g MCH ha-1) against a control treatment over 0.64 ha plots centered within ~1. Read More

    No effect of insect repellents on the behaviour of Lymnaea stagnalis at environmentally relevant concentrations.
    Environ Sci Pollut Res Int 2017 Nov 24;24(33):26120-26124. Epub 2017 Sep 24.
    Cologne Biocenter, Workgroup Aquatic Chemical Ecology, University of Cologne, Zülpicher Strasse 47b, 50674, Köln, Germany.
    Insect repellents are widely applied to various materials and to both human and animal skin to deter mosquitoes and ticks. The most common deterrent compounds applied are DEET, EBAAP and icaridin (picaridin, Bayrepel). Due to their extensive application, these repellents are frequently detected in surface waters in considerable concentrations. Read More

    Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves.
    Biomed Chromatogr 2018 Feb 15;32(2). Epub 2017 Oct 15.
    Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil.
    The rise of the mosquitoes-transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased concerns on protection against mosquitoes bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as repellent, which has been reported as quite efficient by the local press. Read More

    Enhanced dimethyl phthalate biodegradation by accelerating phthalic acid di-oxygenation.
    Biodegradation 2017 12 23;28(5-6):413-421. Epub 2017 Aug 23.
    Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ, 85287-5701, USA.
    The aerobic biodegradation of dimethyl phthalate (DMP) is initiated with two hydrolysis reactions that generate an intermediate, phthalic acid (PA), that is further biodegraded through a two-step di-oxygenation reaction. DMP biodegradation is inhibited when PA accumulates, but DMP's biodegradation can be enhanced by adding an exogenous electron donor. We evaluated the effect of adding succinate, acetate, or formate as an exogenous electron donor. Read More

    Elimination and ecotoxicity evaluation of phthalic acid esters from textile-dyeing wastewater.
    Environ Pollut 2017 Dec 8;231(Pt 1):115-122. Epub 2017 Aug 8.
    School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China.
    Phthalic acid esters (PAEs), presented in fabrics, surfactants and detergents, were discharged into the ecosystem during textile-dyeing wastewater treatment and might have adverse effects on water ecosystems. In this study, comprehensive investigations of the content and component distributions of 12 PAEs across different units of four textile-dyeing wastewater plants were carried out in Guangdong Province, China. Ecotoxicity assessments were also conducted based on risk quotients (RQs). Read More

    DBP formation from degradation of DEET and ibuprofen by UV/chlorine process and subsequent post-chlorination.
    J Environ Sci (China) 2017 Aug 23;58:146-154. Epub 2017 Jun 23.
    School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, China.
    The formation of disinfection by-products (DBPs) from the degradation of N,N-diethyl-3-methyl benzoyl amide (DEET) and ibuprofen (IBP) by the ultraviolet irradiation (UV)/chlorine process and subsequent post-chlorination was investigated and compared with the UV/HOprocess. The pseudo first-order rate constants of the degradation of DEET and IBP by the UV/chlorine process were 2 and 3.1 times higher than those by the UV/HOprocess, respectively, under the tested conditions. Read More

    Glucosinolate Profiles in Cabbage Genotypes Influence the Preferential Feeding of Diamondback Moth ().
    Front Plant Sci 2017 18;8:1244. Epub 2017 Jul 18.
    Department of Horticulture, Sunchon National UniversitySuncheon, South Korea.
    Diamondback moth (DBM),L., is a devastating pest of cabbage worldwide whose feeding attributes are influenced by glucosinolate profiles of the plant. Identifying the specific glucosinolates associated with plants' resistance mechanism can provide cues to novel points of intervention in developing resistant cultivars. Read More

    Oliv. essential oil: Chemical composition and antimicrobial, insect-repellent and anticholinesterase activities.
    Saudi Pharm J 2017 Jul 1;25(5):703-708. Epub 2016 Nov 1.
    Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, 26470 Eskisehir, Turkey.
    The essential oil (EO) of the aerial parts ofOliv. (Asteraceae), was obtained by hydrodistillation. The oil was subsequently analyzed by both GC-FID and GC-MS, simultaneously. Read More

    Knowledge and Prevention Practices among U.S. Pregnant Immigrants from Zika Virus Outbreak Areas.
    Am J Trop Med Hyg 2017 Jul;97(1):155-162
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.
    We administered an anonymous survey to assess knowledge, attitudes, and prevention practices related to the Zika virus among pregnant women residing in Texas. Multivariate logistic regression models controlling for age, race/ethnicity, education, and number of years in the United States assessed differences between women born in outbreak areas (= 390) versus those born in the United States (= 249). Results demonstrated that most women wanted more information on the Zika virus and desired to obtain it from their physician. Read More

    Anti-feeding and insecticidal efficacy of a topical administration of dinotefuran-pyriproxyfen-permethrin spot-on (Vectra® 3D) on mice against Stegomyia albopicta (= Aedes albopictus).
    Med Vet Entomol 2017 12 17;31(4):351-357. Epub 2017 Jul 17.
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix-Marseille Université, UM63, Centre National de la Recherche Scientifique (CNRS) 7278, Institut de Recherche pour le Développement (IRD) 198 (Dakar), Institut National de la Santé et de la Recherche Médicale (INSERM) 1095, Assistance-Publique Hôpitaux de Marseille (AP-HM) Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
    An ectoparasiticide combining three active ingredients [dinotefuran, permethrin and pyriproxyfen (DPP)] was used in mice in an experiment designed to evaluate its anti-feeding and insecticidal efficacy against Stegomyia albopicta (= Aedes albopictus) (Diptera: Culicidae) mosquitoes. Twenty-two adult mice were randomly allocated into two groups consisting of an untreated control group and a DPP-treated group. Mice were exposed individually for 1 h to a mean ± standard deviation of 27 ± 2 starved female mosquitoes on days 1, 7, 14, 21 and 28 post-treatment. Read More

    Electrochemical Synthesis of Dihydrobenzofurans and Evaluation of Their Insect Antifeedant Activities.
    J Oleo Sci 2017 Aug 12;66(8):857-862. Epub 2017 Jul 12.
    Department of Applied Biological Chemistry, School of Agriculture, Kindai University.
    Electrochemically synthesized dihydrobenzofurans were evaluated for their insect antifeedant activities against phytophagous insects. They were prepared through the coupling reactions of various alkenes with a phenoxy cation generated by oxidation near the cathode in the electrolytic reaction. The insect antifeedant activities of these synthetic dihydrobenzofurans were evaluated in the common cutworm (Spodoptera litura) and diamond back moth (Plutella xylostella) with the dual choice leaf disk bioassay method. Read More

    In vitro assessment of phthalate acid esters-trypsin complex formation.
    Chemosphere 2017 Oct 1;185:29-35. Epub 2017 Jul 1.
    School of Marine Science and Technology, Harbin Institute of Technology, Weihai, 264209, PR China.
    In this work, interactions of three phthalate acid esters (PAEs), including dimethyl phthalate (DMP), diethyl phthalate (DEP) and dibutyl phthalate (DBP), with trypsin have been studied in vitro, under simulated physiological conditions using multi-spectroscopic techniques and molecular modeling. The results show that these PAEs can bind to the trypsin, forming trypsin-PAEs complexes, mainly via hydrophobic interactions, with the affinity order of DMP > DEP > DBP. Binding to the PAEs is found to result in molecular deformation of trypsin. Read More

    Evaluation of Host-Derived Volatiles for Trapping Culicoides Biting Midges (Diptera: Ceratopogonidae).
    J Chem Ecol 2017 Jul 3;43(7):662-669. Epub 2017 Jul 3.
    Unit of Chemical Ecology, Department of Plant Protection Biology Swedish University of Agricultural Sciences, Box 102, 230 53, Alnarp, Sweden.
    Culicoides biting midges (Diptera: Ceratopognidae) cause pain and distress through blood feeding, and transmit viruses that threaten both animal and human health worldwide. There are few effective tools for monitoring and control of biting midges, with semiochemical-based strategies offering the advantage of targeting host-seeking populations. In previous studies, we identified the host preference of multiple Culicoides species, including Culicoides impunctatus, as well as cattle-derived compounds that modulate the behavioral responses of C. Read More

    Protection against mosquito vectors Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus using a novel insect repellent, ethyl anthranilate.
    Acta Trop 2017 Oct 27;174:56-63. Epub 2017 Jun 27.
    Defence Research Laboratory, Tezpur, Assam 784001, India. Electronic address:
    Growing concern on the application of synthetic mosquito repellents in the recent years has instigated the identification and development of better alternatives to control different mosquito-borne diseases. In view of above, present investigation evaluates the repellent activity of ethyl anthranilate (EA), a non-toxic, FDA approved volatile food additive against three known mosquito vectors namely, Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus under laboratory conditions following standard protocols. Three concentration levels (2%, 5% and 10% w/v) of EA were tested against all the three selected mosquito species employing K & D module and arm-in-cage method to determine the effective dose (ED) and complete protection time (CPT), respectively. Read More

    Evaluation of knowledge and use of the malaria prevention measures among the patients of the Department of Tropical and Parasitic Diseases University Center of Maritime and Tropical Medicine, Gdynia, based on a questionnaire performed in the years 2012-20
    Przegl Epidemiol 2017;71(1):33-44
    Medical University of Gdańsk, Institute of Maritime and Tropical Medicine, Chair of Tropical Medicine and Parasitology – National Center for Tropical Medicine, Department of Tropical Parasitology, Gdynia.
    Introduction: Every year, approximately 125 million travelers visit areas where malaria prevails, located in over 100 countries. Over 10,000 of them suffer from malaria annually. Visitors to these areas may protect themselves against infection by using chemoprophylaxis, insect repellents, appropriate clothing, sleeping in airconditioned and well-screened quarters or using mosquito nets impregnated with insecticides. Read More

    Video Tracking Protocol to Screen Deterrent Chemistries for Honey Bees.
    J Vis Exp 2017 Jun 12(124). Epub 2017 Jun 12.
    Entomology, University of Nebraska-Lincoln.
    The European honey bee, Apis mellifera L., is an economically and agriculturally important pollinator that generates billions of dollars annually. Honey bee colony numbers have been declining in the United States and many European countries since 1947. Read More

    Next generation sequencing of oral microbiota in Type 2 diabetes mellitus prior to and after neem stick usage and correlation with serum monocyte chemoattractant-1.
    Diabetes Res Clin Pract 2017 Aug 13;130:204-210. Epub 2017 Jun 13.
    Shrimpex Biotech Services Private Limited, Sholinganallur, Chennai, Tamil Nadu, India.
    Introduction: Oral microbiome impacts health and disease. T2DM and periodontitis are associated. Neem (Azadiracta indica) has antibacterial activity against oral microbiota. Read More

    Infrared light detection by the haller's organ of adult american dog ticks, Dermacentor variabilis (Ixodida: Ixodidae).
    Ticks Tick Borne Dis 2017 Aug 13;8(5):764-771. Epub 2017 Jun 13.
    Department of Entomology and Plant Pathology, Campus Box 7647, 3230 Ligon Street, North Carolina State University, Raleigh, NC, 27695-7647, USA. Electronic address:
    The Haller's organ (HO), unique to ticks and mites, is found only on the first tarsus of the front pair of legs. The organ has an unusual morphology consisting of an anterior pit (AP) with protruding sensilla and a posterior capsule (Cp). The current thinking is that the HO's main function is chemosensation analogous to the insect antennae, but the functionality of its atypical structure (exclusive to the Acari) is unexplained. Read More

    The seroprevalence of West Nile Virus in Israel: A nationwide cross sectional study.
    PLoS One 2017 16;12(6):e0179774. Epub 2017 Jun 16.
    Central Virology Laboratory, Ministry of Health, Public Health Services, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel.
    West Nile Virus (WNV) is endemic in Israel, affecting yearly 40-160 individuals. Israel is located on a central migratory path between Africa and Eurasia and most West Nile Fever (WNF) cases reported in recent years were among residents of the coastal plain. The aim of the study was to evaluate the seroprevalence of WNV among the Israeli population and to assess correlates for WNV infection. Read More

    Hydronopylformamides: Modification of the Naturally Occurring Compound (-)-β-Pinene to Produce Insect Repellent Candidates against Blattella germanica.
    Molecules 2017 Jun 16;22(6). Epub 2017 Jun 16.
    College of Forestry, Jiangxi Agricultural University, Camphor Tree Engineering and Technology Research Center of State Forestry Administration and Jiangxi Province, Nanchang 330045, Jiangxi, China.
    The development of a novel repellent plays an important role in the integrated control of. A series of novel hydronopylformamides derivatives were synthesized from a naturally occurring compound (-)-β-pinene. The structures of these hydronopylformamides derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (¹H-NMR andC-NMR), and electron impact mass spectrometry (EI-MS). Read More

    Reported community-level indoor residual spray coverage from two-stage cluster surveys in sub-Saharan Africa.
    Malar J 2017 Jun 13;16(1):249. Epub 2017 Jun 13.
    Department of Public Health, Food Studies and Nutrition, Syracuse University, Syracuse, NY, USA.
    Background: Malaria is an important cause of morbidity and mortality in malaria-endemic areas. Indoor residual spray is an effective intervention to control malaria, but high community-level coverage is needed to maximize its impact.

    Methods And Results: Using thirty-four two-stage cluster surveys (e. Read More

    Ethnobotanical survey of medicinal plants used as insects repellents in six malaria endemic localities of Cameroon.
    J Ethnobiol Ethnomed 2017 Jun 8;13(1):33. Epub 2017 Jun 8.
    Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
    Background: The combined efforts to combat outdoor/indoor transmission of malaria parasites are hampered by the emerging vector resistance in a wide variety of malaria-endemic settings of Africa and the rest of the world, stressing the need for alternative control measures. This study aimed at documenting insect's repellent plant species used by indigenous populations of 6 localities of East, South, West and Centre regions of Cameroon.

    Methods: Information was gathered through face-to-face interviews guided by a semi-structured questionnaire on the knowledge of medicinal plants with insect repellent properties. Read More

    Measures Taken to Prevent Zika Virus Infection During Pregnancy - Puerto Rico, 2016.
    MMWR Morb Mortal Wkly Rep 2017 Jun 9;66(22):574-578. Epub 2017 Jun 9.
    Zika virus infection during pregnancy remains a serious health threat in Puerto Rico. Infection during pregnancy can cause microcephaly, brain abnormalities, and other severe birth defects (1). From January 1, 2016 through March 29, 2017, Puerto Rico reported approximately 3,300 pregnant women with laboratory evidence of possible Zika virus infection (2). Read More

    Sulfate turpentine: a resource of tick repellent compounds.
    Exp Appl Acarol 2017 Jul 6;72(3):291-302. Epub 2017 Jun 6.
    Department of Chemistry, School of Chemical Science and Engineering, Ecological Chemistry Group, KTH, Royal Institute of Technology, 100 44, Stockholm, Sweden.
    Compounds with tick (Ixodes ricinus) repellent properties were isolated from sulfate turpentine consisting of Norway spruce (80%) and Scots pine (20%) from southern Sweden. The turpentine was divided into two fractions by distillation under reduced pressure resulting in one monoterpene hydrocarbon fraction and a residual containing higher boiling terpenoids. The monoterpene fraction was further oxidized with SeOto obtain oxygenated monoterpenes with potential tick repellent properties. Read More

    Effects of sublethal exposure to metofluthrin on the fitness of Aedes aegypti in a domestic setting in Cairns, Queensland.
    Parasit Vectors 2017 May 31;10(1):274. Epub 2017 May 31.
    College of Public Health, Medical and Veterinary Sciences, James Cook University, PO Box 6811, QLD, Cairns, 4870, Australia.
    Background: Metofluthrin is highly effective at reducing biting activity in Aedes aegypti. Its efficacy lies in the rapid onset of confusion, knockdown, and subsequent kill of a mosquito. In the field, there are a variety of scenarios that might result in sublethal exposure to metofluthrin, including mosquitoes that are active at the margins of the chemical's lethal range, brief exposure as mosquitoes fly in and out of treated spaces or decreasing efficacy of the emanators with time. Read More

    Mosquito-Borne Diseases as a Global Health Problem: Implications for Pregnancy and Travel.
    Obstet Gynecol Surv 2017 May;72(5):309-318
    Associate Professor, Obstetrics, Gynecology and Reproductive Health Sciences, Harvard Medical School; and Chair, Division of Global Health, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA.
    Importance: Mosquitoes are the most common disease vectors worldwide. A combination of factors, including changes in public health policy, climate change, and global travel, has led to the resurgence and spread of these diseases in our modern world. Pregnant women are vulnerable to a number of these illnesses, and obstetricians are likely to encounter pregnant travelers who have been exposed. Read More

    A New In Vitro Bioassay System for the Discovery and Quantitative Evaluation of Mosquito Repellents.
    J Med Entomol 2017 Sep;54(5):1328-1336
    National Center for Natural Products Research, The University of Mississippi, University, MS 38677.
    Mosquitoes vector many pathogens that cause human diseases. Repellents play a significant role in reducing the risk of these diseases by preventing mosquito bites. In this paper, we are reporting an Ali and Khan (A & K), large cage in vitro bioassay system that can effectively be used to measure repellency of compounds against mosquitoes. Read More

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