23,847 results match your criteria Innovations in Cardiac Rhythm Management [Journal]


Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology.

J Natl Cancer Inst 2018 Dec 17. Epub 2018 Dec 17.

Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins, Baltimore, MD.

Traditionally, drug development has evaluated dose, safety, activity, and comparative benefit in a sequence of phases using trial designs and endpoints specifically devised for each phase. Innovations in drug development seek to consolidate the phases and rapidly expand accrual with "seamless" trial designs. Although consolidation and rapid accrual may yield efficiencies, widespread use of seamless first-in-human (FiH) trials without careful consideration of objectives, statistical analysis plans, or trial oversight raises concerns. Read More

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http://dx.doi.org/10.1093/jnci/djy196DOI Listing
December 2018

Perceptions of a longitudinal standardized patient experience by standardized patients, medical students, and faculty.

Med Educ Online 2018 Dec;23(1):1548244

d Department of Medicine , Northwell Health, Center for Health Innovations & Outcomes Research , Manhasset , NY , USA.

Background: Longitudinal standardized patient (LSP) experiences mimic clinical practice by allowing students to interact with standardized patients (SPs) over time. LSP cases facilitate practice, assessment, and feedback in clinical skills and foster an appreciation for the continuum of care.

Objective: We sought to characterize the nature of relationship-building, feedback, and continuity among all stakeholders participating in a single LSP program. Read More

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http://dx.doi.org/10.1080/10872981.2018.1548244DOI Listing
December 2018

Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry.

J Endocr Soc 2019 Jan 26;3(1):42-51. Epub 2018 Oct 26.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Context: Accurate glucagon level measurements are necessary for investigation of mechanisms for postprandial hyperglycemia in type 2 diabetes.

Objective: To evaluate the accuracy of postprandial glucagon level measurements using a sandwich ELISA vs a recently established liquid chromatography-high resolution mass spectrometry (LC-HRMS) method in type 2 diabetes mellitus.

Design And Participants: Twenty patients with type 2 diabetes treated with insulin underwent a meal test before and after administration of the dipeptidyl peptidase-4 inhibitor anagliptin for 4 weeks. Read More

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http://dx.doi.org/10.1210/js.2018-00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293234PMC
January 2019

CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success.

Front Immunol 2018 3;9:2740. Epub 2018 Dec 3.

Center for Cellular Immunotherapies, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States.

Chimeric antigen receptor (CAR)-engineered T cells represent a breakthrough in personalized medicine. In this strategy, a patient's own T lymphocytes are genetically reprogrammed to encode a synthetic receptor that binds a tumor antigen, allowing T cells to recognize and kill antigen-expressing cancer cells. As a result of complete and durable responses in individuals who are refractory to standard of care therapy, CAR T cells directed against the CD19 protein have been granted United States Food and Drug Administration (FDA) approval as a therapy for treatment of pediatric and young adult acute lymphoblastic leukemia and diffuse large B cell lymphoma. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287001PMC
December 2018

Neoadjuvant FOLFIRINOX for Patients with Borderline Resectable or Locally Advanced Pancreatic Cancer: Results of a Decision Analysis.

Oncologist 2018 Dec 17. Epub 2018 Dec 17.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: The effectiveness and cost-effectiveness of using neoadjuvant FOLFIRINOX (nFOLFIRINOX) for patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA PDAC) are unknown. Our objective was to determine whether nFOLFIRINOX is more effective or cost-effective for patients with BR/LA PDAC compared with upfront resection surgery and adjuvant gemcitabine plus capecitabine (GEM/CAPE) or gemcitabine monotherapy (GEM).

Materials And Methods: We performed a decision-analysis to assess the value of nFOLFIRINOX versus GEM/CAPE or GEM using a mathematical simulation model. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0114DOI Listing
December 2018

GPs' attitudes towards digital technologies for depression: an online survey in primary care.

Br J Gen Pract 2018 Dec 17. Epub 2018 Dec 17.

Psychiatry, and licensed clinical psychologist, Amsterdam UMC, Department of Psychiatry, University of Amsterdam, Amsterdam, the Netherlands.

Background: Digital or electronic mental health (e-mental health) interventions can be useful approaches in reducing the burden of depression, with tools available for use in prevention, treatment, or relapse prevention. They may have specific benefit for primary care, as depression is often managed in this setting. However, little is known about attitudes and barriers among GPs towards e-mental health interventions for depression. Read More

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http://dx.doi.org/10.3399/bjgp18X700721DOI Listing
December 2018

iPSCs and aging.

Nihon Rinsho 2016 Sep;74(9):1560-1564

In addition to the discovery that mature cells can be reprogrammed to become pluripotent stem cells(iPS cells), the technical innovations of big-data analyses as well as the cutting- edge technologies such as nuclear reprogramming technique and genome-editing system are emerging a big paradigm shift in the field of regenerative medicine and aging. This is bonafide a kind of the molecular biological movement of the Renaissance to answer the question of 120 years ago "D'ofi Venons Nous Que Sommes Nous Oi Allons Nous", a testament of Paul Gauguin. These technologies enable us, particularly inexhaustible researchers with challenging spirits, not only to dynamically, qualitatively and visually systematically understand underling mechanisms of single gene, single molecule, single cell and their complicated networks in vivo with broadly combining them from cells to organs and individuals', but also to pursue the mechanistic insight into "Life, Aging, Disease, and Death" and thereby con- trol them. Read More

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September 2016

Cultural Perspectives on Tobacco Use and Cessation Among Chinese American Immigrants: A Community-Engaged Qualitative Study.

J Transcult Nurs 2018 Dec 17:1043659618817583. Epub 2018 Dec 17.

3 Chinese Consolidated Benevolent Association of New England, Boston, MA, USA.

Introduction: Tobacco use is a preventable cause of death among ethnic minorities. Chinese Americans have high smoking rates and underutilize evidence-based cessation therapies. Community members' perspectives on tobacco use and cessation may help bridge treatment gaps and ensure that cessation approaches are aligned with cultural values. Read More

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http://dx.doi.org/10.1177/1043659618817583DOI Listing
December 2018

Using a cross-contextual reciprocal learning approach in a multisite implementation research project to improve self-management for type 2 diabetes.

BMJ Glob Health 2018 26;3(6):e001068. Epub 2018 Nov 26.

Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

This paper reports on the use of reciprocal learning for identifying, adopting and adapting a type 2 diabetes self-management support intervention in a multisite implementation trial conducted in a rural setting in a low-income country (Uganda), a periurban township in a middle-income country (South Africa) and socioeconomically disadvantaged suburbs in a high-income country (Sweden). The learning process was guided by a framework for knowledge translation and structured into three learning cycles, allowing for a balance between evidence, stakeholder interaction and contextual adaptation. Key factors included commitment, common goals, leadership and partnerships. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267315PMC
November 2018

Around the clock: gradient shape and noise impact the evolution of oscillatory segmentation dynamics.

Evodevo 2018 10;9:24. Epub 2018 Dec 10.

2Theoretical Biology, Utrecht University, Padualaan 8, 3584CH Utrecht, Netherlands.

Background: Segmentation, the subdivision of the major body axis into repeated elements, is considered one of the major evolutionary innovations in bilaterian animals. In all three segmented animal clades, the predominant segmentation mechanism is sequential segmentation, where segments are generated one by one in anterior-posterior order from a posterior undifferentiated zone. In vertebrates and arthropods, sequential segmentation is thought to arise from a clock-and-wavefront-type mechanism, where oscillations in the posterior growth zone are transformed into a segmental prepattern in the anterior by a receding wavefront. Read More

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http://dx.doi.org/10.1186/s13227-018-0113-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288972PMC
December 2018

Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP/PSEN1 transgenic mice.

EBioMedicine 2018 Dec 13. Epub 2018 Dec 13.

Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.. Electronic address:

Background: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP/PSEN1) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are detected. Recently, the importance of microglia has become apparent in the human disease. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.12.006DOI Listing
December 2018

Guidelines, good practices and best clinical health practices: valuable guidance for physicians and judges?

Clin Ter 2018 Nov-Dec;169(6):e292-e296

Dipartimento di Scienze anatomiche, istologiche, medico-legali e dell'apparato locomotore, Sezione di Medicina legale, Università "Sapienza" di Roma.

Enactment of law n. 24, 8th March 2017, (so-called "Gelli-Bianco" law), has given rise to substantial innovations in the realm of medical liability: on the one hand, an attempt has been made towards redefining the boundaries of professional liability, for the purpose of curbing the use of "defensive medicine"; on the other hand, there is the effort to delineate good medical conduct by means of "institutionalization" and a greater degree of consistency of guidelines and good clinical health care practices. There are, however, thought-provoking cues concerning the relationship between the two concepts, which can be sensibly developed, even in light of international scientific literature. Read More

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December 2018

Miniaturised 'antibody'-drug conjugates for solid tumours?

Drug Discov Today Technol 2018 Dec 17;30:47-53. Epub 2018 Oct 17.

Antikor Biopharma Ltd, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, UK; Dept. of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK. Electronic address:

With Antibody-Drug Conjugate strategies firmly focussed on the precise conjugation to the large protein Immunoglobulin-G format, it is easy to miss the more recent technological innovations in small-format drug conjugates. Here, the targeting ligand can be at 50-95% reduced in size, or even smaller if peptidic in nature. Antibody domains or alternative binding scaffolds, chemically-modified with ultra-potent cytotoxic payloads offer an alternative approach for oncology therapeutics, promising a wider therapeutic window by virtue of superior solid tumour penetration properties and more rapid system clearance. Read More

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http://dx.doi.org/10.1016/j.ddtec.2018.09.006DOI Listing
December 2018
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A decade of Nucleic Acid Programmable Protein Arrays (NAPPA) availability: News, actors, progress, prospects and access.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:

Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More

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http://dx.doi.org/10.1016/j.jprot.2018.12.007DOI Listing
December 2018

[Radiological imaging to assess individual cardiovascular risk].

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Clinical/methodical Issue: Radiologic imaging for the assessment of individual cardiovascular risk.

Standard Radiological Methods: The correct estimation of the individual cardiovascular risk is prerequisite for the prevention of cardiovascular diseases. Here, extensive evidence is available for coronary calcium scans as well as coronary CT angiography (CTA). Read More

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http://dx.doi.org/10.1007/s00117-018-0480-7DOI Listing
December 2018
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Evaluation of stakeholder views on peer review of NIHR applications for funding: a qualitative study.

BMJ Open 2018 Dec 14;8(12):e022548. Epub 2018 Dec 14.

Wessex Institute, University of Southampton, Southampton, UK.

Objectives: Innovations resulting from research have both national and global impact, so selecting the most promising research studies to fund is crucial. Peer review of research funding applications is part of the selection process, and requires considerable resources. This study aimed to elicit stakeholder opinions about which factors contribute to and influence effective peer review of funding applications to the UK National Institute for Health Research (NIHR), and to identify possible minor improvements to current processes and any major changes or potential innovations to achieve a more efficient peer review process. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022548DOI Listing
December 2018

Redesigning primary care in the safety net: A qualitative analysis of team-based care implementation.

Healthc (Amst) 2018 Dec 11. Epub 2018 Dec 11.

University of California San Francisco, Center for Vulnerable Populations, Division of General Internal Medicine, United States.

Background: Team-based care is an innovative approach to primary care in which groups of health care professionals work collaboratively to manage care for groups of patients. Safety-net organizations face specific barriers to implementing health care innovations. More research is needed that documents the dynamics that inform implementation and sustainment of innovative practices in the safety net. Read More

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http://dx.doi.org/10.1016/j.hjdsi.2018.09.004DOI Listing
December 2018

International priorities for home care education, research, practice, and management: Qualitative content analysis.

Nurse Educ Today 2018 Dec 7;73:83-87. Epub 2018 Dec 7.

Case Western Reserve University, United States of America. Electronic address:

Background: Despite growing demand for home care nursing, there is a growing home care workforce shortage, due in part to hospital-centric nursing curricula that lead students to undervalue of home care and community practice setting (Van Iersel et al., 2018a, 2018b).

Objectives: Articulate an international vision for the future of home care education, research, practice, and management shared by experienced home care nurses working in leadership roles. Read More

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http://dx.doi.org/10.1016/j.nedt.2018.11.020DOI Listing
December 2018

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020.

BJOG 2019 Jan;126(2):237-243

The Royal Hospital for Women, Randwick, NSW, Australia.

Over 8 million babies have been born following IVF (in vitro fertilisation) and other artificial reproductive technology (ART) procedures since Louise Brown's birth 40 years ago. New innovations have added much complexity to both clinical and laboratory procedures over the last four decades. Translation of novel approaches from basic science into clinical practice continues unabated, widening the applicability of ART to new groups of people and helping improve both chances of healthy live birth and patient acceptability. Read More

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http://dx.doi.org/10.1111/1471-0528.15526DOI Listing
January 2019

Targeted Minimally Invasive Parathyroidectomy for Ectopic Aortopulmonary Adenoma Under Gamma Probe Guidance.

Innovations (Phila) 2018 Nov/Dec;13(6):451-454

Department of Cardiovascular Surgery, Heart Center, Cebeci Hospitals, Ankara University School of Medicine, Ankara, Turkey.

We report a case of 53-year-old woman with the parathyroid adenoma (PA) located in the aortopulmonary window with an aberrant right subclavian artery. Her preoperative calcium level was 11.3 mg/dL (reference range = 8. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000562DOI Listing
December 2018
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Minimally Invasive Periareolar Approach to Cor Triatriatum Repair.

Innovations (Phila) 2018 Nov/Dec;13(6):445-447

From the Division of Cardiac Surgery.

Cor triatriatum sinister is an uncommon cardiac abnormality characterized by a membrane that divides the left atrium into two chambers. Definitive management requires surgical resection, traditionally through sternotomy. Minimally invasive reparative techniques are associated with reduced blood loss, shorter hospitalization, faster recovery time, and improved cosmesis with excellent patient satisfaction. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000565DOI Listing
December 2018

Can Robotic-Assisted Surgery Overcome the Risk of Mortality in Cardiac Reoperation?

Innovations (Phila) 2018 Nov/Dec;13(6):438-444

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD USA.

Objective: A robotic-assisted approach potentially has many advantages for cardiac reoperation, which include sternum-sparing and three-dimensional visualization leading to precise adhesiolysis and excellent exposure in a limited field.

Methods: We retrospectively reviewed our patients undergoing robotic cardiac reoperation (redo group) from July 2013 to April 2017 at our institution and compared with our patients undergoing standard robotic surgery (nonredo group). In the reoperative cases, a thoracoscope was inserted through a 5-mm port placed away from the previous scar. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000567DOI Listing
December 2018

Right Mini-Thoracotomy Subaortic Membrane Resection.

Innovations (Phila) 2018 Nov/Dec;13(6):428-432

From the Division of Cardiac Surgery, University of Rochester Medical Center, Rochester, NY USA.

Objective: Subaortic membrane is an anatomical intracardiac anomaly that may cause discrete subaortic stenosis and aortic insufficiency. Patients requiring subaortic membrane resection may benefit from a minimally invasive approach; however, subaortic membranes are typically resected through a median sternotomy. We present our initial clinical experience of adult patients who have undergone a mini-thoracotomy subaortic membrane resection. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000564DOI Listing
December 2018

Economic evaluations in community aged care: a systematic review.

BMC Health Serv Res 2018 Dec 14;18(1):967. Epub 2018 Dec 14.

Institute for Choice, University of South Australia Business School, Adelaide, SA, Australia.

Background: This paper reports the methods and findings from a systematic review of economic evaluations conducted in the community aged care sector between 2000 and 2016.

Methods: Online databases searched were PubMed, Medline, Scopus, and web of science, CINAHL and informit. Studies were included if they 1) were full economic evaluations that compared both the costs and outcomes of two or more interventions 2) in study population of people aged 65 years and over 3) dependent older people living in the community 4) alternatives being compared were care models or service delivery interventions in the community aged care sector (a group of programs that have been established as a support system to allow older people to remain living in their own homes for as long as possible, as an alternative to institutional or residential care) and 5) published in the English language between 2000 and November 2016. Read More

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http://dx.doi.org/10.1186/s12913-018-3785-3DOI Listing
December 2018
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Prevalence of geophagy and knowledge about its health effects among native Sub-Saharan Africa, Caribbean and South America healthy adults living in France.

Eat Weight Disord 2018 Dec 13. Epub 2018 Dec 13.

Service de Médecine Interne et des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Reims, 51092, Reims, France.

Geophagy is widespread among women from Sub-Saharan Africa, South America and the Caribbean and may persist in western countries. This practice may be associated with adverse effects such as anaemia, constipation or intestinal occlusion. We aimed to determine the prevalence of geophagy and the level of knowledge about its health effects among healthy adults originating from these countries and attending a travel medicine and international vaccination consultation in France. Read More

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http://link.springer.com/10.1007/s40519-018-0624-9
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http://dx.doi.org/10.1007/s40519-018-0624-9DOI Listing
December 2018
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Glaucoma - Next Generation Therapeutics: Impossible to Possible.

Pharm Res 2018 Dec 13;36(2):25. Epub 2018 Dec 13.

Ophthalmology Research, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts, 02139, USA.

The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administered as topical drops. Read More

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http://link.springer.com/10.1007/s11095-018-2557-4
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http://dx.doi.org/10.1007/s11095-018-2557-4DOI Listing
December 2018
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"Just Carbon": Ideas About Graphene Risks by Graphene Researchers and Innovation Advisors.

Nanoethics 2018 22;12(3):199-210. Epub 2018 Oct 22.

2Gothenburg Research Institute, University of Gothenburg, PO Box 603, 405 30 Gothenburg, Sweden.

Graphene is a nanomaterial with many promising and innovative applications, yet early studies indicate that graphene may pose risks to humans and the environment. According to ideas of responsible research and innovation, all relevant actors should strive to reduce risks related to technological innovations. Through semi-structured interviews, we investigated the idea of graphene as a risk (or not) held by two types of key actors: graphene researchers and innovation advisors at universities, where the latter are facilitating the movement of graphene from the laboratory to the marketplace. Read More

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http://link.springer.com/10.1007/s11569-018-0324-y
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http://dx.doi.org/10.1007/s11569-018-0324-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267168PMC
October 2018
1 Read

Giving Voice to Patients: Developing a Discussion Method to Involve Patients in Translational Research.

Nanoethics 2018 9;12(3):181-197. Epub 2018 Jul 9.

4Wageningen University and Research, Wageningen, The Netherlands.

Biomedical research policy in recent years has often tried to make such research more 'translational', aiming to facilitate the transfer of insights from research and development (R&D) to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. Read More

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http://dx.doi.org/10.1007/s11569-018-0319-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267162PMC

Sustainable food systems-a health perspective.

Sustain Sci 2018 12;13(6):1505-1517. Epub 2018 Jun 12.

7Departments of Population Health and of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.

Malnutrition in all forms, ranging from undernourishment to obesity and associated diet-related diseases, is one of the leading causes of death worldwide, while food systems often have major environmental impacts. Rapid global population growth and increases in demands for food and changes in dietary habits create challenges to provide universal access to healthy food without creating negative environmental, economic, and social impacts. This article discusses opportunities for and challenges to sustainable food systems from a human health perspective by making the case for avoiding the transition to unhealthy less sustainable diets (using India as an exemplar), reducing food waste by changing consumer behaviour (with examples from Japan), and using innovations and new technologies to reduce the environmental impact of healthy food production. Read More

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http://dx.doi.org/10.1007/s11625-018-0586-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267166PMC
June 2018
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REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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http://dx.doi.org/10.1038/s41564-018-0295-3DOI Listing
January 2019

Catalyzing marketing innovation and competitive advantage in the healthcare industry: the value of thinking like an outsider.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):922. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Marketing arguably is the most critical administrative responsibility associated with the pursuit and realization of growth and prosperity, making prowess in the discipline essential for any healthcare institution, especially given the competitive intensity that characterizes the industry. But in order to truly gain an advantage, healthcare establishments must tap into innovative pathways that their competitors have yet to discover. Here, thinking like an outsider can pay tremendous dividends, as health and medical organizations tend to focus inwardly, limiting their exposure to externally-derived innovations and advancements which often can supply differentiation opportunities. Read More

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http://dx.doi.org/10.1186/s12913-018-3682-9DOI Listing
December 2018

Healthcare establishments as owner-operators of digital billboards: making the most of excellent roadside visibility and high traffic counts to better connect with patients.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):928. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Given the importance of communicating effectively with current and prospective patients, healthcare institutions must direct considerable energies toward achieving associated excellence. Pursuits usually center on addressing the marketing communications mix properly, but in order to maximize communications prowess, attention also should be directed toward incorporating emerging communications innovations, when and where possible, to bolster opportunities to connect with patients.

Discussion: In pursuit of communications excellence, Willis-Knighton Health System's executives reflected on campus dynamics in the context of modern outdoor advertising technologies, namely, digital billboards, which present electronic advertisements on-demand, around-the-clock. Read More

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http://dx.doi.org/10.1186/s12913-018-3680-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293496PMC
December 2018

Engaging patients, enhancing patient experiences: insights, innovations, and applications.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):925. Epub 2018 Dec 14.

Department of Health Services Administration, University of Alabama at Birmingham, School of Health Professions Building, 5th Floor, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.

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https://bmchealthservres.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12913-018-3675-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293485PMC
December 2018
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Environmental and social responsibility of companies cross EU countries - Panel data analysis.

Sci Total Environ 2018 Dec 5;657:287-296. Epub 2018 Dec 5.

University of Belgrade, Technical Faculty Bor, VJ 12, 19210 Bor, Serbia; Mining and Metallurgy Institute Bor, Zeleni Bulevar 35, 19210 Bor, Serbia. Electronic address:

In recent years, the socio-environmental dimension has become a structural and strategic element of successful companies, where it is usually addressed through the concept of Corporate Social Responsibility. The challenge for business is to draft new paradigms for operational procedures and improve the business conditions towards social and environmental responsibilities. Companies focus on eco-innovations and the production of "green products". Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.482DOI Listing
December 2018

Outcomes After the MitraClip Procedure in Patients at Very High Risk for Conventional Mitral Valve Surgery.

Innovations (Phila) 2018 Nov/Dec;13(6):433-437

From the Divisions of Cardiothoracic Surgery and.

Objective: Approximately 50% of patients with severe symptomatic mitral regurgitation are deemed too high risk for surgery. The MitraClip procedure is a viable option for this population. Our goal was to assess outcomes and survival of patients who underwent the MitraClip procedure at an institution where mitral valve surgery is routinely performed. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296819PMC
November 2019

Stented Versus Stentless Aortic Valve Replacement in Patients With Small Aortic Root: A Systematic Review and Meta-Analysis.

Innovations (Phila) 2018 Nov/Dec;13(6):404-416

Manchester Royal Infirmary, Manchester, United Kingdom.

Objective: The aim of the study was to compare hemodynamic and perioperative outcomes of stented against stentless aortic valve replacement in patients with small aortic root (21 mm or less).

Methods: A comprehensive search was undertaken among the four major databases (PubMed, Embase, Scopus, and Ovid) to identify all randomized and nonrandomized controlled trials comparing stentless to stented bioprosthetic valves in small aortic root patients. Odds ratios, weighted mean differences, or standardized mean differences and their 95% confidence intervals were analyzed. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000569DOI Listing
December 2018

Minimally Invasive and Robotic Esophagectomy: A Review.

Innovations (Phila) 2018 Nov/Dec;13(6):391-403

Division of Thoracic Surgery, Robert Tucker Hayes Foundation, University of Texas Southwestern Medical Center, Dallas, TX USA.

Great advances have been made in the surgical management of esophageal disease since the first description of esophageal resection in 1913. We are in the era of minimally invasive esophagectomy. The current three main approaches to an esophagectomy are the Ivor Lewis technique, McKeown technique, and the transhiatal approach to esophagectomy. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000572DOI Listing
December 2018

Heterogeneous Recommendations for Oncology Products Among Different HTA Systems: A Comparative Assessment.

Recent Results Cancer Res 2019 ;213:39-55

Public Health Department, Research Unit EA 3279, Aix-Marseille University, Marseille, France.

Rising budget constraints and demands for healthcare services create additional complexity within the decision process for resource allocation. Innovations and scientific progress have been shown to be key drivers of the increase in healthcare expenditures (1). In the context of rising medical care costs and limited resources, Health Technology Assessment (HTA) was developed as a tool to inform decision-making and to provide the rationalization behind these decisions driving resource allocation and spending for health technology products. Read More

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http://dx.doi.org/10.1007/978-3-030-01207-6_4DOI Listing
January 2019

"Closing the Gap": Provider Recommendations for Implementing Birth Point of Care HIV Testing.

AIDS Behav 2018 Dec 12. Epub 2018 Dec 12.

Department of Family Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

Delays in traditional HIV DNA PCR testing for early infant diagnosis (EID) at 6 weeks of age result in late antiretroviral treatment (ART). Birth point of care (POC) testing is an emerging strategy with the potential to streamline EID services. We elicited providers' recommendations for introducing birth POC testing to guide strategies in Kenya and similar settings. Read More

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http://dx.doi.org/10.1007/s10461-018-2363-3DOI Listing
December 2018
1 Read

Secular trends in Dietary Inflammatory Index among adults in the United States, 1999-2014.

Eur J Clin Nutr 2018 Dec 12. Epub 2018 Dec 12.

Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, USA.

Objective: The objective of this study was to evaluate secular trends in Dietary Inflammatory Index (DII) scores in the United States between 1999 and 2014.

Methods: Data from adults over 19 years from the 1999 to 2014 National Health and Nutrition Examination Survey (N = 39,191) were used. DII scores, at each 2-year cycle, were evaluated from a 24-h recall, including 26 food parameters for DII calculation. Read More

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http://dx.doi.org/10.1038/s41430-018-0378-5DOI Listing
December 2018

Assessment of unmet needs to address noncompliant households during polio supplemental immunization activities in Kaduna state, 2014-2016.

BMC Public Health 2018 Dec 13;18(Suppl 4):1309. Epub 2018 Dec 13.

World Health Organization Country Office, Abuja, Nigeria.

Background: Despite concerted global efforts being made to eradicate poliomyelitis, the wild poliovirus still circulates in three countries, including Nigeria. In addition, Nigeria experiences occasional outbreaks of the circulating vaccine-derived poliovirus type 2 (cVDPV2). Vaccine rejection by caregivers persists in some parts of northern Nigeria, which compromises the quality of supplemental immunization activities (SIAs). Read More

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http://dx.doi.org/10.1186/s12889-018-6192-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291916PMC
December 2018

Targeting the last polio sanctuaries with Directly Observed Oral Polio Vaccination (DOPV) in northern Nigeria, (2014-2016).

BMC Public Health 2018 Dec 13;18(Suppl 4):1314. Epub 2018 Dec 13.

World Health Organization, Country Representative Office, Abuja, Nigeria.

Background: The declaration of poliomyelitis eradication as a programmatic emergency for global public health by the 65th World Health Assembly in 2012 necessitated innovations and strategies to achieve results. Review of the confirmed polio cases in 2013 showed that most of the cases were from non-compliant households, where parents connived with vaccinators to finger mark the children without actually vaccinating the children with oral polio vaccine or children were absent from home at the time of the visit of vaccinators.

Methods: We used pre-post design to quantify the outcomes of directly observed vaccination in 90 local government areas from 12 northern Nigeria states at very high risk of polio transmission. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-018-6182-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291915PMC
December 2018
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A National Survey of Transplant Surgeons and Nephrologists on Implementing Apolipoprotein L1 ( APOL1) Genetic Testing Into Clinical Practice.

Prog Transplant 2018 Dec 13:1526924818817048. Epub 2018 Dec 13.

5 Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Introduction:: There is debate over whether Apolipoprotein L1 (APOL1) gene risk variants contribute to African American (AA) live donors' (LD) increased risk of kidney failure. Little is known about factors influencing physicians' integration of APOL1 genetic testing of AA LDs into donor evaluation.

Design:: We conducted a cross-sectional survey, informed by Roger's Diffusion of Innovations theory, among nephrology and surgeon members of the American Society of Nephrology, American Society of Transplantation, and American Society of Transplant Surgeons about their practices of and attitudes about APOL1 genetic testing of AA potential LDs. Read More

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http://dx.doi.org/10.1177/1526924818817048DOI Listing
December 2018

Quasi-Experimental Evaluation of LifeCourse on Utilization and Patient and Caregiver Quality of Life and Experience.

Am J Hosp Palliat Care 2018 Dec 13:1049909118817740. Epub 2018 Dec 13.

4 Allina Health, Minneapolis, MN, USA.

Whole-person care is a new paradigm for serious illness, but few programs have been robustly studied. We sought to test the effect of LifeCourse (LC), a person-centered program for patients living with serious illness, on health-care utilization, care experience, and quality of life, employing a quasi-experimental design with a Usual Care (UC) comparison group. The study was conducted 2012 to 2017 at an upper-Midwest not-for-profit health-care system with outcomes measured every 3 months until the end of life. Read More

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http://dx.doi.org/10.1177/1049909118817740DOI Listing
December 2018
2 Reads

Quantitative Genetics and Genomics Converge to Accelerate Forest Tree Breeding.

Front Plant Sci 2018 22;9:1693. Epub 2018 Nov 22.

Department of Forest and Conservation Sciences, Faculty of Forestry, University of British Columbia Vancouver, BC, Canada.

Forest tree breeding has been successful at delivering genetically improved material for multiple traits based on recurrent cycles of selection, mating, and testing. However, long breeding cycles, late flowering, variable juvenile-mature correlations, emerging pests and diseases, climate, and market changes, all pose formidable challenges. Genetic dissection approaches such as quantitative trait mapping and association genetics have been fruitless to effectively drive operational marker-assisted selection (MAS) in forest trees, largely because of the complex multifactorial inheritance of most, if not all traits of interest. Read More

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http://dx.doi.org/10.3389/fpls.2018.01693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262028PMC
November 2018

Needs and Expectations of Patients with Erectile Dysfunction: An Update on Pharmacological Innovations in Phosphodiesterase Type 5 Inhibition with Focus on Sildenafil.

Sex Med 2018 Dec 3. Epub 2018 Dec 3.

Urology and Andrology Department, CHU de Nîmes-Montpellier 1 University School of Medicine, Nîmes, France.

Introduction: Phosphodiesterase type 5 inhibitors (PDE5-Is) have an excellent efficacy and tolerability profile and remain the first-line choice for the treatment of erectile dysfunction (ED). However, ED is still an underdiagnosed and undertreated condition, and many men prematurely discontinue therapy with conventional dosage formulations despite successful intercourse.

Aim: To review the unmet needs and expectations of patients with ED and describe the latest pharmaceutical innovations in the field of PDE5-I formulations designed to address these needs, with particular reference to a new orodispersible film (ODF) formulation of the PDE5-I, sildenafil. Read More

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http://dx.doi.org/10.1016/j.esxm.2018.10.005DOI Listing
December 2018

[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0761-3409
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http://dx.doi.org/10.1055/a-0761-3409DOI Listing
December 2018
2 Reads

Associations between general practice characteristics with use of urgent referrals for suspected cancer and endoscopies: a cross-sectional ecological study.

Fam Pract 2018 Dec 12. Epub 2018 Dec 12.

The Health Improvement Institute (THIS), University of Cambridge, Cambridge, UK.

Background: Large variation in measures of diagnostic activity has been described previously between English general practices, but related predictors remain understudied.

Objective: To examine associations between general practice population and characteristics, with the use of urgent referrals for suspected cancer, and use of endoscopy.

Methods: Cross-sectional observational study of English general practices. Read More

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http://dx.doi.org/10.1093/fampra/cmy118DOI Listing
December 2018
1.842 Impact Factor