23,783 results match your criteria Innovations Philadelphia Pa.[Journal]


Differences in perceptions of e-cigarettes across daily and non-daily users.

Addict Behav 2018 Dec 5;90:415-420. Epub 2018 Dec 5.

Department of Psychology, University of Houston, Houston, TX, United States; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Health Institute, University of Houston, Houston, TX, United States. Electronic address:

Objective: E-cigarette use has increased significantly over the past decade. Among the growing population of e-cigarette users, several pattern-based subgroups have emerged, including daily and non-daily users. Daily users are at greater risk for experiencing negative health consequences from use. Read More

View Article
December 2018
1 Read

Adjuvant Therapy for Biliary Tract Cancers: Desperately Seeking Data.

J Oncol Pract 2018 Dec;14(12):719-720

Center for Innovations in Quality, Effectiveness, and Safety at the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX.

View Article
December 2018

Remodeling Medicaid.

Authors:
Joey Berlin

Tex Med 2018 Jul 1;114(7):16-21. Epub 2018 Jul 1.

House calls, yoga classes, and community networks are among the value-based innovations making Medicaid more patient-centered and more penny-wise. Read More

View Article

Factor Analysis of Negative Symptom Items in the Structured Interview for Prodromal Syndromes.

Schizophr Bull 2018 Dec 8. Epub 2018 Dec 8.

Department of Psychology, Department of Psychiatry, Department of Medical Social Sciences, Institute for Policy Research, Institute for Innovations in Developmental Sciences, Northwestern University, Evanston, IL.

Background: Negative symptoms occur early in the clinical high risk (CHR) state and indicate increased risk of conversion to psychotic disorder and poor functional outcome. However, while the negative symptom domain has shown to be parsimoniously explained by a 2-factor construct in schizophrenia, there has yet to be an established factor structure of negative symptoms in CHR.

Methods: 214 individuals meeting the Structured Interview for Psychosis-Risk Syndromes (SIPS) criteria for CHR were recruited through 3 active research programs in the United States. Read More

View Article
December 2018

Multimodal Intravascular Photoacoustic and Ultrasound Imaging.

Biomed Eng Lett 2018 May 26;8(2):193-201. Epub 2018 Mar 26.

Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA 92617 USA.

The rupture of atherosclerotic plaques is the leading cause of death in developed countries. Early identification of vulnerable plaque is the essential step in preventing acute coronary events. Intravascular photoacoustic (IVPA) technology is able to visualize chemical composition of atherosclerotic plaque with high specificity and sensitivity. Read More

View Article

Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation.

J Transplant 2018 8;2018:9205083. Epub 2018 Nov 8.

Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada.

Background: Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes.

Methods: Three hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011. Read More

View Article
November 2018

Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil.

World J Hepatol 2018 Nov;10(11):867-876

Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21040360, Brazil.

Aim: To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.

Methods: A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory ( = 100), South ( = 89) and Northeast ( = 114) Health Center, Southeast ( = 77) and Northeast ( = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. Read More

View Article
November 2018
1 Read

Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment.

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Section of Plastic and Reconstructive Surgery, Michigan Medicine, Ann Arbor, MI.

Nonvascularized bone grafts (NBGs) represent a practical method of mandibular reconstruction that is precluded in head and neck cancer patients by the destructive effects of radiotherapy. Advances in tissue-engineering may restore NBGs as a viable surgical technique, but expeditious translation demands a small-animal model that approximates clinical practice. This study establishes a murine model of irradiated mandibular reconstruction using a segmental iliac crest NBG for the investigation of imperative bone healing strategies. Read More

View Article
December 2018

Opportunities to observe and measure intangible inputs to innovation: Definitions, operationalization, and examples.

Proc Natl Acad Sci U S A 2018 Dec;115(50):12638-12645

Social and Decision Analytics Laboratory, Biocomplexity Institute of Virginia Tech, Arlington, VA 22203.

Measuring the value of intangibles is not easy, because they are critical but usually invisible components of the innovation process. Today, access to nonsurvey data sources, such as administrative data and repositories captured on web pages, opens opportunities to create intangibles based on new sources of information and capture intangible innovations in new ways. Intangibles include ownership of innovative property and human resources that make a company unique but are currently unmeasured. Read More

View Article
December 2018

How science and technology developments impact employment and education.

Authors:
Wendy Martinez

Proc Natl Acad Sci U S A 2018 Dec;115(50):12624-12629

Office of Survey Methods Research, US Bureau of Labor Statistics, Washington, DC 20212

A better understanding of how developments in science and technology influence the creation of new occupations and subsequent changes in educational programs can help decision makers at all levels of our society. As a result of research and development efforts, innovations are achieved, resulting in the creation of new occupations and the demand for employees with expertise in these new areas. To fulfill the demand, universities and colleges often revise their programs to address these needs. Read More

View Article
December 2018

Forecasting innovations in science, technology, and education.

Proc Natl Acad Sci U S A 2018 Dec;115(50):12573-12581

Center for Polymer Studies, Boston University, Boston, MA 02215.

View Article
December 2018

Twin-Win Model: A human-centered approach to research success.

Authors:
Ben Shneiderman

Proc Natl Acad Sci U S A 2018 Dec;115(50):12590-12594

Department of Computer Science & Human-Computer Interaction Lab, University of Maryland, College Park, MD 20814

A 70-year-old simmering debate has erupted into vigorous battles over the most effective ways to conduct research. Well-established beliefs are being forcefully challenged by advocates of new research models. While there can be no final resolution to this battle, this paper offers the Twin-Win Model to guide teams of researchers, academic leaders, business managers, and government funding policymakers. Read More

View Article
December 2018

What's happening in Innovations in Care Delivery.

Authors:

Neurology 2018 Dec;91(24):1091

View Article
December 2018

Ecotoxicoproteomics: A decade of progress in our understanding of anthropogenic impact on the environment.

J Proteomics 2018 Dec 6. Epub 2018 Dec 6.

Laboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, F-30207 Bagnols-sur-Cèze, France. Electronic address:

Anthropogenic pollutants are found worldwide. Their fate and effects on human and ecosystem health must be appropriately monitored. Today, ecotoxicology is focused on the development of new methods to assess the impact of pollutant toxicity on living organisms and ecosystems. Read More

View Article
December 2018
2 Reads

A bright future: optogenetics to dissect the spatiotemporal control of cell behavior.

Curr Opin Chem Biol 2018 Dec 4;48:106-113. Epub 2018 Dec 4.

Department of Molecular Biology, Princeton University, Princeton NJ 08544, United States. Electronic address:

Cells sense, process, and respond to extracellular information using signaling networks: collections of proteins that act as precise biochemical sensors. These protein networks are characterized by both complex temporal organization, such as pulses of signaling activity, and by complex spatial organization, where proteins assemble structures at particular locations and times within the cell. Yet despite their ubiquity, studying these spatial and temporal properties has remained challenging because they emerge from the entire protein network rather than a single node, and cannot be easily tuned by drugs or mutations. Read More

View Article
December 2018

Characterization of Neurite Dystrophy After Trauma by High Speed Structured Illumination Microscopy and Lattice Light Sheet Microscopy.

J Neurosci Methods 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, NorthShore University HealthSystem, Evanston, Illinois, USA. Electronic address:

Background: Unbiased screening studies have repeatedly identified actin-related proteins as one of the families of proteins most influenced by neurotrauma. Nevertheless, the status quo model of cytoskeletal reorganization after neurotrauma excludes actin and incorporates only changes in microtubules and intermediate filaments. Actin is excluded in part because it is difficult to image with conventional techniques. Read More

View Article
December 2018

Bullying victimization in typically developing and clinical high risk (CHR) adolescents: A multimodal imaging study.

Schizophr Res 2018 Dec 7. Epub 2018 Dec 7.

Northwestern University, Department of Psychology, USA; Northwestern University, Department of Psychiatry, USA; Northwestern University, Department of Medical Social Sciences, USA; Northwestern University, Institute for Policy Research, USA; Northwestern University, Institute for Innovations in Developmental Sciences, USA.

Background: Bullying has been shown to increase the risk of developing a psychotic disorder. To date, no studies have examined brain behavior relationships within the context of bullying victimization in clinical high-risk (CHR) youth, a group characterized by both gray and white matter abnormalities. The present study employed multimodal neuroimaging to examine possible neural mechanisms associated with bullying victimization. Read More

View Article
December 2018

A population-based analysis of endovascular aortic stent graft therapy in patients with liver cirrhosis.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taipei, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taipei, Taiwan. Electronic address:

Background: Endovascular aneurysm repair (EVAR) and thoracic endovascular aortic repair (TEVAR) are effective and minimally invasive treatments for high-risk surgical candidates. However, information about the management of EVAR and TEVAR in liver cirrhosis (LC) is lacking. The aim of our study was to evaluate outcomes after EVAR and TEVAR in patients with LC. Read More

View Article
October 2018

Haematological immune-related adverse events induced by anti-PD-1 or anti-PD-L1 immunotherapy: a descriptive observational study.

Lancet Haematol 2018 Dec 4. Epub 2018 Dec 4.

Service de Médecine Interne and Immunologie Clinique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France; Université Paris Sud, Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto-Immunes, INSERM, Le Kremlin-Bicêtre, France; Division d'Immunovirologie, Commissariat à l'Energie Atomique et aux Energies Alternatives, Fontenay-aux-Roses, France.

Background: Anti-programmed cell death 1 (PD-1) and anti-programmed cell death ligand 1 (PD-L1) antibodies are novel immunotherapies for cancer that can induce immune-related adverse events (irAEs). These adverse events can involve all organs, including the haemopoietic system. Thus far, haematological irAEs (haem-irAEs) have not been extensively characterised. Read More

View Article
December 2018

AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders.

J Pain 2018 Dec 4. Epub 2018 Dec 4.

Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO.

Peripheral neuropathic pain is among the most prevalent types of neuropathic pain. No comprehensive peripheral neuropathic pain classification system that incorporates contemporary clinical, diagnostic, biological, and psychological information exists. To address this need, this article covers the taxonomy for 4 focal or segmental peripheral neuropathic pain disorders, as part of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS) collaborative to develop a standardized, evidence-based taxonomy initiative: the ACTTION-APS Pain Taxonomy (AAPT). Read More

View Article
December 2018

Surgical Resident Burnout and Job Satisfaction: The Role of Workplace Climate and Perceived Support.

J Surg Res 2019 Feb 27;234:20-25. Epub 2018 Sep 27.

Virginia Commonwealth University, Department of Surgery, Richmond, Virginia.

Background: Surgical residents train under immense stress, often manifesting into poor well-being. While recent research identifies methods of coping with stress, few studies empirically investigate the role of the environment on surgical resident well-being. We aimed to assess surgical resident perceptions of workplace climate, organizational support, burnout, and job satisfaction to test a mediation model identifying antecedents to well-being. Read More

View Article
February 2019

Basics of iterative reconstruction methods in computed tomography: A vendor-independent overview.

Authors:
Wolfram Stiller

Eur J Radiol 2018 Dec 26;109:147-154. Epub 2018 Oct 26.

Diagnostic & Interventional Radiology (DIR), Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Over the past two decades, technical innovations in computed tomography (CT) have constantly extended its spectrum of clinical applications and made new radiodiagnostic applications accessible. At the same time, concerns have arisen with respect to the radiation exposure to the patients caused by CT examinations. In order to address this issue, different strategies for radiation dose reduction in CT have been introduced, spanning technical approaches as well as specific examination techniques applied in clinical practice, such as reduced-dose CT. Read More

View Article
December 2018

Technological innovations in infection control: A rapid review of the acceptance of behavior monitoring systems and their contribution to the improvement of hand hygiene.

Am J Infect Control 2018 Dec 5. Epub 2018 Dec 5.

Institute of Nursing Science, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Hand hygiene is crucial for preventing nosocomial infections; however, adherence rates need further attention. Prevention of nosocomial infections through regular hand hygiene monitoring and feedback is recommended by the World Health Organization. Technology holds the potential for achieving this goal. Read More

View Article
December 2018

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death.

Elife 2018 Dec 7;7. Epub 2018 Dec 7.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, United States.

Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression of some tumors, although the underlying mechanism has remained unknown. Here we show that secretoglobin(SCGB)3A2, a small protein predominantly secreted in airways, chaperones LPS to the cytosol through the cell surface receptor syndecan-1; this leads to pyroptotic cell death driven by caspase-11. Read More

View Article
December 2018

Berberine Effects on NFκB, HIF1A and NFE2L2/AP-1 Pathways in HeLa Cells.

Anticancer Agents Med Chem 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Innovations LLC, 112 Mechnikova st., 344013, Rostov-on-Don. Russian Federation.

Background: Berberine has multitudinous anti-cancer stem cells effects making it a highly promising candidate substance for the next-generation cancer therapy. However, berberine modes of action predispose it to significant side-effects that probably limit its clinical testing and application.

Materials And Method: HeLa cells were treated with two concentrations of berberine (30 and 100 μM) for 24 hours to asses the functioning of the NFE2L2/AP-1, NFκB and HIF1A pathways using 22 RNAs expression qPCR-based analysis. Read More

View Article
December 2018

Older Adult Preferences of Mobile Application Functionality Supporting Medication Self-Management.

J Health Commun 2018 Dec 10:1-8. Epub 2018 Dec 10.

a Division of General Internal Medicine , Feinberg School of Medicine at Northwestern University , Chicago , IL , USA.

Health systems and insurers alike are increasingly interested in leveraging mHealth (mobile health) tools to support patient health-related behaviors including medication adherence. However, these tools are not widely used by older patients. This study explores patient preferences for functionality in a smartphone application (app) that supports medication self-management among older adults with multiple chronic conditions. Read More

View Article
December 2018

Improving Drug Development and Patient Access With the Right People, Processes, and Culture: What Needs to Happen Right Now to Bring Better Medicines to the Patients Who Need Them.

Ther Innov Regul Sci 2018 Dec 10:2168479018814224. Epub 2018 Dec 10.

1 PAREXEL International Corp, Waltham, MA, USA.

In a global environment where health care costs are soaring, R&D efforts are flatlining. Meanwhile, payers are demanding more value for their money. In this environment, the traditional siloed drug development model is not sustainable. Read More

View Article
December 2018

Distinguished Career Contributions to Education and Training in Psychology Award: Carol A. Falender.

Authors:

Am Psychol 2018 Dec;73(9):1237-1239

The Award for Distinguished Career Contributions to Education and Training in Psychology is given in recognition of the efforts of psychologists who have made distinguished contributions to education and training, who have produced imaginative innovations, or who have been involved in the developmental phases of programs in education and training in psychology. The Career designation is added to the award at the discretion of the Education and Training Awards Committee to recognize continuous significant contributions made over a lifelong career in psychology. The 2018 recipient of this award is Carol A. Read More

View Article
December 2018

Award for Distinguished Contributions to Education and Training in Psychology.

Authors:

Am Psychol 2018 Dec;73(9):1236

This award is given by the Board of Educational Affairs in recognition of the efforts of psychologists who have made distinguished contributions to education and training, who have produced imaginative innovations, or who have been involved in the developmental phases of programs in education and training in psychology. These contributions might include important research on education and training; the development of effective materials for instruction; the establishment of workshops, conferences, or networks of communication for education and training; achievement and leadership in administration that facilitates education and training; or activity in professional organizations that promote excellence. The Award for Distinguished Contributions to Education and Training in psychology recognizes a specific contribution to education and training. Read More

View Article
December 2018

[Journey around the heart in the movies of the last century: from Charlie Chaplin to the present day].

Authors:
Andrea Pozzati

G Ital Cardiol (Rome) 2018 Dec;19(12):664-667

U.O.S. Cardiologia, Ospedale Dossetti di Bazzano (BO), AUSL di Bologna.

Imagine a journey through the cinema's history to recover the figure of the doctor in the last century. At the same time, we have found that the progress of medicine has conditioned the stories told on the big screen. Cardiology has achieved a leading role at the cinema when technological innovations have begun to emerge, from the '60s onwards. Read More

View Article
December 2018
1 Read

Comparative effectiveness of vitamin D supplementation via buccal spray versus oral supplements on serum 25-hydroxyvitamin D concentrations in humans: a systematic review protocol.

JBI Database System Rev Implement Rep 2018 Dec 3. Epub 2018 Dec 3.

The Institute of Health and Community, University of Plymouth and The University of Plymouth Centre for Innovations in Health and Social Care.

REVIEW QUESTION:: the questions of this review are. Read More

View Article
December 2018

Needs-focused interventions for family caregivers of older adults with cancer: a descriptive interpretive study.

Support Care Cancer 2018 Dec 5. Epub 2018 Dec 5.

Faculty of Medicine and Health Sciences, Université de Sherbrooke, Longueuil, QC, Canada.

Purpose: Although family caregivers (FCs) of older adults with cancer (OACs) provide invaluable assistance by fulfilling multiple tasks along the cancer trajectory, evidence suggests that their needs are poorly assessed, and there is a scarcity of supportive interventions that influence their well-being. Viewing these issues as opportunities for improvement, we conducted this qualitative study to understand FCs' needs and identify promising needs-focused interventions.

Methods: This descriptive interpretive qualitative study was conducted in Quebec, Canada, in a French Canadian Oncology Clinic. Read More

View Article
December 2018

Advances in coarse-grained modeling of macromolecular complexes.

Curr Opin Struct Biol 2018 Nov 30;52:119-126. Epub 2018 Nov 30.

Department of Chemistry, The University of Chicago, Chicago, IL, USA. Electronic address:

Recent progress in coarse-grained (CG) molecular modeling and simulation has facilitated an influx of computational studies on biological macromolecules and their complexes. Given the large separation of length-scales and time-scales that dictate macromolecular biophysics, CG modeling and simulation are well-suited to bridge the microscopic and mesoscopic or macroscopic details observed from all-atom molecular simulations and experiments, respectively. In this review, we first summarize recent innovations in the development of CG models, which broadly include structure-based, knowledge-based, and dynamics-based approaches. Read More

View Article
November 2018
1 Read

The HEAAL Project: Applying Community-Based Participatory Research (CBPR) Methodology in a Health and Mental Health Needs Assessment With an African Immigrant and Refugee Faith Community in Lowell, Massachusetts.

J Public Health Manag Pract 2019 Jan/Feb;25(1):E1-E6

Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts (Ms Oppenheim and Drs Tam, Henderson, and Borba); Department of Psychiatry, Boston Medical Center, Boston, Massachusetts (Ms Oppenheim and Drs Tam, Henderson, and Borba); Innovations in Healthcare, Duke University, Durham, North Carolina (Ms Axelrod); and Christ Jubilee International Ministries, Lowell, Massachusetts (Mr Menyongai and Ms Chukwuezi).

Community-based participatory research methodology is driven by community interests and rooted in community involvement throughout the research process. This article describes the use of community-based participatory research methodology in the HEAAL project (Health and Mental Health Education and Awareness for Africans in Lowell), a research collaboration between Christ Jubilee International Ministries-a nondenominational Christian church in Lowell, Massachusetts, that serves an African immigrant and refugee congregation-and the Massachusetts General Hospital Department of Psychiatry. The objective of the HEAAL project was to better understand the nature, characteristics, scope, and magnitude of health and mental health issues in this faith community. Read More

View Article
January 2020

Endoscopic management of perforations, leaks and fistulas.

Transl Gastroenterol Hepatol 2018 31;3:85. Epub 2018 Oct 31.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The endoscopic management armamentarium of gastrointestinal disruptions including perforations, leaks, and fistulas has slowly but steadily broadened in recent years. Previously limited to surgical or conservative medical management, innovations in advanced endoscopic techniques like natural orifice transluminal endoscopic surgery (NOTES) have paved the path towards development of endoscopic closure techniques. Early recognition of a gastrointestinal defect is the most important independent variable in determining successful endoscopic closure and patient outcome. Read More

View Article
October 2018
1 Read

Innovations in digital interventions for psychological trauma: harnessing advances in cognitive science.

Mhealth 2018 19;4:47. Epub 2018 Oct 19.

Centre for Children's Health Research, Institute of Health and Biomedical Innovation, and School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.

A range of digital psychological interventions have demonstrated a positive impact on trauma-related problems in controlled trials, but there is room for further improvements in their form, reach and impact. Most to date have been adaptions of established face-to-face treatments. In this paper, we highlight a complementary emerging route to their development, which draws on advances in cognitive science theory and research and applies them to clinical contexts. Read More

View Article
October 2018

The clinical utility of tumor mutational burden in non-small cell lung cancer.

Transl Lung Cancer Res 2018 Dec;7(6):639-646

Aix Marseille University, Assistance Publique Hôpitaux de Marseille, Multidisciplinary Oncology & Therapeutic Innovations department, Marseille, France.

Despite advances made during the last two decades, lung cancer remains the leading cause of cancer-related death worldwide. Recently, immune checkpoint inhibitors (ICIs) became available for the treatment of advanced non-small cell lung cancer (NSCLC) patients. Although ICIs showed a survival advantage in comparison with chemotherapy in the second and first-line setting, overall response rate is only around 20% and a large proportion of patients will undergo disease progression within the first weeks of treatment. Read More

View Article
December 2018
1 Read

Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.

Adv Funct Mater 2018 Oct 14;28(44). Epub 2018 Sep 14.

Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69 Street, New York, NY 10021, USA,

An effective tumoral delivery system should show minimal removal by the reticuloendothelial system (RES), promote tumor uptake and penetration, and minimize on-site clearance. This study reports the design and synthesis of advanced self-assembling peptide nanofiber precursor (NFP) analogues. The peptidic nature of NFP offers the design flexibility for on-demand customization with imaging agents and surface charges while maintaining a set size, allowing for real-time monitoring of kinetic and dynamic tumoral delivery by multimodal fluorescence/positron emission tomography/computed tomography (fluo/PET/CT) imaging, for formulation optimization. Read More

View Article
October 2018
1 Read

Evolution of pharmacology education in India: Past and future.

Authors:
Dinesh K Badyal

Indian J Pharmacol 2018 Jul-Aug;50(4):159-168

Department of Pharmacology, Christian Medical College and Hospital, Ludhiana, Punjab, India.

Pharmacology education has passed through various stages in the evolution sequence due to ever-changing type and repository of drugs as well as technological advancements in the educational processes. This article reviews the journey of evolution of pharmacology education. Pharmacology is relevant component of various curricula in medical, dental, and paramedical courses. Read More

View Article
December 2018

The dietary inflammatory index and insulin resistance or metabolic syndrome in young adults.

Nutrition 2018 Aug 23;58:187-193. Epub 2018 Aug 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA; Connecting Health Innovations, Columbia, USA.

Objective: The aim of this study was to assess the association between the inflammatory potential of diet, as measured by the dietary inflammatory index (DII) and insulin resistance (IR) or metabolic syndrome (MetS).

Methods: A cross-sectional study (nested within a cohort) was conducted on 2017 adults 23 to 25 y of age in Ribeirão Preto, Brazil. Food consumption was assessed using a validated food frequency questionnaire. Read More

View Article

Oropouche orthobunyavirus: Genetic characterization of full-length genomes and development of molecular methods to discriminate natural reassortments.

Infect Genet Evol 2018 Nov 29;68:16-22. Epub 2018 Nov 29.

The Center for Genome Science, US Army Medical Research Institute of Infectious Disease at Fort Detrick, MD, USA.

Oropouche orthobunyavirus (OROV) has significant impact in public health in Amazon region. This arbovirus is one of the most common causes of febrile illness in Brazil, and is responsible for several epidemics since 1960's. In this study, we sequenced and characterized the complete coding sequences (S-, M- and L-RNA) of 35 OROV isolates from Brazil. Read More

View Article
November 2018

The effects of alignment of an articulated ankle-foot orthosis on lower limb joint kinematics and kinetics during gait in individuals post-stroke.

J Biomech 2018 Nov 22. Epub 2018 Nov 22.

Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.

Mechanical tuning of an ankle-foot orthosis (AFO) is important in improving gait in individuals post-stroke. Alignment and resistance are two factors that are tunable in articulated AFOs. The aim of this study was to investigate the effects of changing AFO ankle alignment on lower limb joint kinematics and kinetics with constant dorsiflexion and plantarflexion resistance in individuals post-stroke. Read More

View Article
November 2018

Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

Ann Epidemiol 2018 Nov 2. Epub 2018 Nov 2.

Division of Research, Kaiser Permanente Northern California, Oakland.

Purpose: The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk.

Methods: Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9. Read More

View Article
November 2018

The origin and evolution of sewing technologies in Eurasia and North America.

J Hum Evol 2018 Dec 3;125:71-86. Epub 2018 Nov 3.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 142 Xizhimenwai Street, Beijing 100044, China; CAS Center for Excellence in Life and Paleoenvironment, 142 Xizhimenwai Street, Beijing 100044, China. Electronic address:

When, how, and following which paths hominins created the innovations that allowed them to colonize regions of the planet that were not suited to their thermal physiology is still a matter of inquiry. In this paper, we elaborate a theoretical framework to investigate the origin and diversification of bone needles, summarize the evidence for their emergence, create a large database of their morphometric and stylistic characters, and present results of the study of an exceptionally well-preserved collection of needles from Shuidonggou Locality 12 (SDG12), a site located in the Ningxia Hui Autonomous Region, Northern China, dated to ca. 11. Read More

View Article
December 2018

The history of suture anchors in orthopaedic surgery.

Clin Biomech (Bristol, Avon) 2018 Nov 23;61:70-78. Epub 2018 Nov 23.

Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba, QLD 4102, Australia; Brisbane Hand and Upper Limb Research Institute, 259 Wickham Terrace, Spring Hill, QLD 4000, Australia; Field Orthopaedics Research Group, 375 Wickham Terrace, Spring Hill, QLD 4000, Australia.

The suture anchor allows secure fixation of soft tissue to bone and has become an invaluable tool for the orthopaedic surgeon. The original suture anchor was developed over 3 decades ago when a suture was bonded to a headless screw. Since then anchors have undergone a wide variety of design modifications to increase strength and allow for new applications based on biomechanical and clinical evidence. Read More

View Article
November 2018

Robust adaptive unscented Kalman filter and its application in initial alignment for body frame velocity aided strapdown inertial navigation system.

Rev Sci Instrum 2018 Nov;89(11):115102

College of Electrical Engineering, Naval University of Engineering, Wuhan 430033, People's Republic of China.

In the in-motion alignment of a strapdown inertial navigation system (SINS), the unscented Kalman filter (UKF) is usually used to solve non-linear problems. The measurement noise covariance has a direct influence on the filtering results of the alignment of the SINS. The measurement noise is assumed to follow Gaussian distribution with a constant covariance . Read More

View Article
November 2018

Sickle Cell and α+-Thalassemia Traits Influence the Association between Ferritin and Hepcidin in Rural Kenyan Children Aged 14-26 Months.

J Nutr 2018 Dec;148(12):1903-1910

Department of Nutrition, University of California, Davis, Davis, CA.

Background: The relation between subclinical hemoglobinopathies and concentrations of the iron-regulatory hormone hepcidin is not well characterized.

Objective: We investigated the relation of hepcidin concentration with hemoglobinopathies among young children in Kenya.

Methods: We quantified serum hepcidin and ferritin in 435 Kenyan children aged 14-20 mo in a subsample of the Water, Sanitation, and Handwashing (WASH) Benefits Trial. Read More

View Article
December 2018
1 Read

Violence against women: historical trajectory of a care program (Curitiba - 1997-2014).

Rev Bras Enferm 2018 Nov-Dec;71(6):2907-2915

Universidade Federal do Paraná. Curitiba, Paraná, Brazil.

Objective: To analyze the historical trajectory and the contributions of the Programa de Atenção às Mulheres em Situação de Violência (Program of Care to Women Victims of Violence) of Curitiba.

Method: Research with documentary and local approach, inspired by the Dimension of Political History, to unveil power relations, political representations, symbols and discourses. Eighty-eight sources were used for the period 1997-2014. Read More

View Article
August 2017
1 Read

The Radiation-Transmission-Reception (RTR) model of propagation: Implications for the effectiveness of network interventions.

PLoS One 2018 5;13(12):e0207865. Epub 2018 Dec 5.

Department of Technology & Operations Management, RSM Erasmus University, Rotterdam, The Netherlands.

Propagating phenomena in networks have received significant amount of attention within various domains, ranging from contagion in epidemiology, to diffusion of innovations and social influence on behavior and communication. Often these studies attempt to model propagation processes in networks to create interventions that steer propagation dynamics towards desired or away from undesired outcomes. Traditionally, studies have used relatively simple models of the propagation mechanism. Read More

View Article
December 2018

Management of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting: Review of the Literature.

Innovations (Phila) 2018 Nov 30. Epub 2018 Nov 30.

From the Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO USA.

Untreated atrial fibrillation is associated with an increased risk of all-cause mortality and morbidity. Despite the current guidelines recommending surgical ablation of atrial fibrillation at the time of coronary artery bypass surgery, most patients with concomitant atrial fibrillation and coronary artery disease do not receive surgical ablation for their atrial fibrillation. This review reports the efficacy of different surgical ablation techniques used for the treatment of atrial fibrillation during coronary artery bypass. Read More

View Article
November 2018