24,338 results match your criteria Innovations Philadelphia Pa.[Journal]


Potential ecotoxicological effects of antimicrobial surface coatings: a literature survey backed up by analysis of market reports.

PeerJ 2019 11;7:e6315. Epub 2019 Feb 11.

Laboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.

This review was initiated by the COST action CA15114 AMICI "Anti-Microbial Coating Innovations to prevent infectious diseases," where one important aspect is to analyze ecotoxicological impacts of antimicrobial coatings (AMCs) to ensure their sustainable use. Scopus database was used to collect scientific literature on the types and uses of AMCs, while market reports were used to collect data on production volumes. Special attention was paid on data obtained for the release of the most prevalent ingredients of AMCs into the aqueous phase that was used as the proxy for their possible ecotoxicological effects. Read More

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http://dx.doi.org/10.7717/peerj.6315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375256PMC
February 2019

Recent advances in proximity-based labeling methods for interactome mapping.

F1000Res 2019 31;8. Epub 2019 Jan 31.

Department of Cellular and Molecular Medicine and Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Proximity-based labeling has emerged as a powerful complementary approach to classic affinity purification of multiprotein complexes in the mapping of protein-protein interactions. Ongoing optimization of enzyme tags and delivery methods has improved both temporal and spatial resolution, and the technique has been successfully employed in numerous small-scale (single complex mapping) and large-scale (network mapping) initiatives. When paired with quantitative proteomic approaches, the ability of these assays to provide snapshots of stable and transient interactions over time greatly facilitates the mapping of dynamic interactomes. Read More

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http://dx.doi.org/10.12688/f1000research.16903.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357996PMC
January 2019

Breakthroughs and new horizons in reproductive biology of rare and endangered animal species.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield S10 2SF, UK.

Because of higher extinction rates due to human and natural factors, more basic and applied research in reproductive biology is required to preserve wild species and design proper strategies leading to sustainable populations. The objective of the review is to highlight recent, inspiring breakthroughs in wildlife reproduction science that will set directions for future research and lead to more successes in conservation biology. Despite new tools and approaches allowing a better and faster understanding of key mechanisms, we still know little about reproduction in endangered species. Read More

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http://dx.doi.org/10.1093/biolre/ioz031DOI Listing
February 2019

Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Background & Aims: The optimal training method for endoscopic characterization of colorectal polyps using narrow-band imaging is uncertain, and sessile serrated lesions (SSLs) optical diagnosis data are lacking. We aimed to evaluate a comprehensive training program for real-time optical diagnosis of colorectal polyps, including SSLs.

Methods: We performed a single-institution prospective study of 15 endoscopists trained with the Workgroup Serrated Polyps and Polyposis classification system. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.019DOI Listing
February 2019

IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy.

Placenta 2019 Feb 10. Epub 2019 Feb 10.

Mother Infant Research Institute, Tufts Medical Center, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, four of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) viviparity in ocean-living species; 2) placental imaging; 3) epigenetics; and 4) extracellular vesicles in pregnancy. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.003DOI Listing
February 2019

Grading venous stenosis is different from arterial lesions.

J Vasc Surg Venous Lymphat Disord 2019 Mar;7(2):151-152

The Rane Center at St. Dominic Hospital, Jackson, Miss. Electronic address:

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http://dx.doi.org/10.1016/j.jvsv.2018.07.020DOI Listing

Current Treatment Options for Breast Cancer Brain Metastases.

Curr Treat Options Oncol 2019 Feb 15;20(3):19. Epub 2019 Feb 15.

Department of Medicine, Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S73, Cleveland, OH, 44195, USA.

Opinion Statement: In the past, the standard of care for treatment of BM was whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), and surgery. There has been a greater role for medical therapies in the last two decades due to the discovery of driver mutations and corresponding targeted therapies. These innovations have dramatically altered the approach to treating these patients. Read More

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http://dx.doi.org/10.1007/s11864-019-0618-5DOI Listing
February 2019

Which flexible ureteroscope is the best for upper tract urothelial carcinoma treatment?

World J Urol 2019 Feb 15. Epub 2019 Feb 15.

Sorbonne Université, Service d'Urologie, Assistance-Publique Hôpitaux de Paris, Hôpital Tenon, 4 Rue de la Chine, 75020, Paris, France.

Purpose: To present attributes of currently available flexible ureteroscopes to define the best flexible ureteroscope for upper tract urothelial carcinoma (UTUC) treatment.

Materials And Methods: Scopus and Medline databases were searched for articles relating to performance of flexible ureteroscopes. A consensus for final inclusion of articles judged to be relevant for UTUC treatment was reached between the authors. Read More

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http://dx.doi.org/10.1007/s00345-019-02675-0DOI Listing
February 2019

Micron resolution, high-fidelity three-dimensional vascular optical imaging phantoms.

J Biomed Opt 2019 Feb;24(2):1-4

Wellcome Trust-EPSRC Centre for Interventional and Surgical Sciences, London, United Kingdom.

Microscopic and mesoscale optical imaging techniques allow for three-dimensional (3-D) imaging of biological tissue across millimeter-scale regions, and imaging phantom models are invaluable for system characterization and clinical training. Phantom models that replicate complex 3-D geometries with both structural and molecular contrast, with resolution and lateral dimensions equivalent to those of imaging techniques (<20  μm), have proven elusive. We present a method for fabricating phantom models using a combination of two-photon polymerization (2PP) to print scaffolds, and microinjection of tailored tissue-mimicking materials to simulate healthy and diseased tissue. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.020502DOI Listing
February 2019

Percutaneous pulmonary valve implantation: It's not like the aortic valve.

Catheter Cardiovasc Interv 2019 Feb;93(3):464-465

Department of Cardiology, Texas Heart Institute, Houston, Texas.

The Edwards Sapien S3 demonstrated clinical and technical feasibility in this cohort undergoing percutaneous pulmonary valve implantation. Traversing the tricuspid apparatus with an unsheathed delivery system continues to pose a risk for tricuspid valve injury. Future design innovations need to accommodate for large outflow tracts without adjacent aortic or coronary compression and allow for safe device delivery with minimal trauma to the tricuspid apparatus. Read More

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http://dx.doi.org/10.1002/ccd.28141DOI Listing
February 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2018 Dec 19. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: KRAS and TP53 are common mutations in non-small-cell lung cancer (NSCLC). The Lung Adjuvant Cisplatin Evaluation Biological Program group found adjuvant chemotherapy to be deleterious in patients with coexisting KRAS/TP53 mutations.

Patients And Methods: To validate these results, patients with NSCLC tested for KRAS and TP53 mutations and receiving chemotherapy for any stage NSCLC were selected. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
December 2018

Microgels: Modular, Tunable Constructs for Tissue Regeneration.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, United States. Electronic address:

Biopolymer microgels are emerging as a versatile tool for aiding in the regeneration of damaged tissues due to their biocompatible nature, tunable microporous structure, ability to encapsulate bioactive factors, and tailorable properties such as stiffness and composition. These properties of microgels, along with their injectability, have allowed for their utilization in a multitude of different tissue engineering applications. Controlled release of growth factors, antibodies, and other bioactive factors from microgels have demonstrated their capabilities as transporters for essential bioactive molecules necessary for guiding tissue reconstruction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.011DOI Listing
February 2019

[The development and application of reagents kit for detection RNA of the causative agents of melioidosis and glanders by transcription-based amplification (NASBA) in real-time.]

Klin Lab Diagn 2018 ;63(10):651-657

Volgograd Anti-Plague Institute of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 40013, Volgograd, Russia.

The polymorphism of clinical manifestations of melioidosis and glanders and their high mortality require improvement of diagnostics for detection of this agents. The perspectivity of development of transcription-based amplification real-time NASBA diagnostic kits is determined by high analytical sensitivity and the opportunity to perfom the verification of the results of other methods for pathogenic Burkholderia species detection. The fragment of 23S rRNA gene was selected as the target for development of real-time NASBA kit. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-651-657DOI Listing
January 2018

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals.

JAMA Netw Open 2019 Feb 1;2(2):e187571. Epub 2019 Feb 1.

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, is unknown.

Objective: To estimate the prevalence, underlying causes, and preventability of sepsis-associated mortality in acute care hospitals. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7571DOI Listing
February 2019

Household saving during pregnancy and facility delivery in Zambia: a cross-sectional study.

Health Policy Plan 2019 Feb 14. Epub 2019 Feb 14.

Department of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA, USA.

Financial barriers cause many women in low- and middle-income countries to deliver outside of a health facility, contributing to maternal and neonatal mortality. Savings accrued during pregnancy can increase access to safe delivery services. We investigated the relationship between household saving during pregnancy and facility delivery. Read More

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http://dx.doi.org/10.1093/heapol/czz005DOI Listing
February 2019

Victoriomyces antarcticus gen. nov., sp. nov., a distinct evolutionary lineage of the Cephalothecaceae (Ascomycota) based on sequence-based phylogeny and morphology.

Int J Syst Evol Microbiol 2019 Feb 15. Epub 2019 Feb 15.

2​Department of Environmental Biology, Sapienza University of Rome, Piazzale A. Moro, 5 -00185 Rome, Italy.

In this study, we propose a new genus, Victoriomyces, with a new species, Victoriomyces antarcticus, isolated from soil samples collected in Victoria Land, Antarctica. To determine its taxonomic status and evolutionary relationships, phylogenetic analysis was performed on DNA sequences from the nuclear 18S rRNA, 28S rRNA and the second largest subunit of RNA polymerase II (RPB2) genes. Victoriomyces antarcticus constitutes one well-supported distinct lineage within the Cephalothecaceae (family incertae sedis in Sordariomycetes), in which the only recognised asexual morphs belong to the genus Phialemonium and to Acremonium thermophilum. Read More

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http://dx.doi.org/10.1099/ijsem.0.003275DOI Listing
February 2019

Use of online opioid overdose prevention training for first-year medical students: A comparative analysis of online versus in-person training.

Subst Abus 2019 Feb 15:1-7. Epub 2019 Feb 15.

f Department of Medicine , New York University School of Medicine , New York , New York , USA.

Purpose: In response to the opioid epidemic and efforts to expand substance use education in medical school, the authors introduced opioid overdose prevention training (OOPT) with naloxone for all first-year medical students (MS1s) as an adjunct to required basic life support training (BLST). The authors previously demonstrated improved knowledge and preparedness following in-person OOPT with BLST; however, it remains unclear whether online-administered OOPT would produce comparable results. In this study, the authors perform a retrospective comparison of online-administered OOPT with in-person-administered OOPT. Read More

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http://dx.doi.org/10.1080/08897077.2019.1572048DOI Listing
February 2019

[Chapter 3. The moral economy of the availability of therapeutic innovations for neglected diseases].

J Int Bioethique Ethique Sci 2018 Jul;29(2):53-67

The main problems of the system governing the development and dissemination of innovative medicines are known. Despite relatively low manufacturing costs, patented drugs are unduly expensive, and neglected diseases attract little pharmaceutical research. Both problems are compounded by patients who, discouraged by high prices, lack of access to competent medical services and low quality medicines, do not complete their treatment. Read More

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http://dx.doi.org/10.3917/jibes.292.0053DOI Listing

[Chapter 6. Legal issues and for the health system of the development of a new class of innovative therapy in oncoimmunology: the “Car-T CellS”].

J Int Bioethique Ethique Sci 2018 07;29(2):113-128

Car-T Cells are autologous or allogeneic lymphocytes cells, genetically engineered to express a transmembrane receptor called ?chimeric? because it consists of the assembly of different parts of molecules. These new techniques using biotechnologies (cellular engineering and genetic modifications) are developing in a complex legal context integrating the rules of the European Union (EU) and national rules, aiming to guarantee a high level of security for products and techniques but also for patients. This framework can be either considered as a guaranty for the use of new molecules in a highly secure environment or as an impediment, on the one hand regarding those who want to develop them because of a great complexity in identifying the adequate procedures and regarding the scientific prerequisites expected by the control agencies, and on the other hand by patients who have to wait many years for these innovations to be made available. Read More

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http://dx.doi.org/10.3917/jibes.292.0113DOI Listing

Grow with the Flow: When Morphogenesis Meets Microfluidics.

Adv Mater 2019 Feb 14:e1805764. Epub 2019 Feb 14.

Department of Complex Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER, Maastricht, The Netherlands.

Developmental biology has advanced the understanding of the intricate and dynamic processes involved in the formation of an organism from a single cell. However, many gaps remain in the knowledge of embryonic development, especially regarding tissue morphogenesis. A possible approach to mimic such phenomena uses pluripotent stem cells in in vitro morphogenetic models. Read More

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http://dx.doi.org/10.1002/adma.201805764DOI Listing
February 2019

Recent Innovations in Diagnosis and Treatment of Pediatric Tuberculosis.

Curr Infect Dis Rep 2019 Feb 15;21(1). Epub 2019 Feb 15.

Medicine-Pediatric Residency Training Program, University of Colorado School of Medicine, Aurora, CO, USA.

Purpose Of Review: Tuberculosis is leading cause of global morbidity and mortality and a significant proportion of the burden of disease occurs in children. In the past 5 years, a number of innovations have improved the diagnosis and treatment for children with both latent tuberculosis infection and active disease.

Recent Findings: This review discusses three key areas of innovation. Read More

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http://link.springer.com/10.1007/s11908-019-0662-0
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http://dx.doi.org/10.1007/s11908-019-0662-0DOI Listing
February 2019
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Parasite loss or parasite gain? Story of nematodes in antipodean waters.

Authors:
Shokoofeh Shamsi

Parasite Epidemiol Control 2019 Feb 25;4:e00087. Epub 2019 Jan 25.

School of Animal and Veterinary Sciences, Graham Centre for Agricultural Innovations, Charles Sturt University, Australia.

spp. are parasitic nematodes belonging to the family Anisakidae. They are known to be able to have highly pathogenic impacts on both wildlife (fish, birds, marine mammals) and humans. Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360457PMC
February 2019

Anesthesia Care Practice Models in the Veterans Health Administration.

Fed Pract 2018 Dec;35(12):22-26

and are Research Health Science Specialists, is a Research Scientist at the Center for Clinical Management Research, and is the Chief of Staff, all at VA Ann Arbor Healthcare System in Michigan. is a Statistician at the W.K. Kellogg Eye Center, University of Michigan, in Ann Arbor. is Research Evidence-Based Practice & Analytics Director and is Liaison for National APRN Policy at the US Department of Veteran Affairs Office of Nursing Services in Washington, DC. Anne Sales is a Professor and the Associate Chair for Educational Programs and Health System Innovations, and Health Infrastructures and Learning Systems, and MS and PhD Programs Director; and Mark Hausman is an Assistant Professor in the Department of Anesthesiology Division of Critical Care Medicine, both at University of Michigan Medical School in Ann Arbor.

Although the VHA primarily relies on teams for anesthesia care, unsupervised certified registered nurse anesthetists also are used to meet veterans' surgical care needs. Read More

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December 2018

The effect of block and traditional periodization training models on jump and sprint performance in collegiate basketball players.

Biol Sport 2018 Dec 31;35(4):373-382. Epub 2018 Aug 31.

Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.

This study investigated the effect of block periodization (BP) and traditional periodization (TP) approaches on jumping and sprinting performance in collegiate basketball players during an 8-week pre-season period. Ten collegiate male basketball players (mean±SD; age: 21.5±1. Read More

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http://dx.doi.org/10.5114/biolsport.2018.78058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358525PMC
December 2018

Molecular mechanism and history of non-sense to sense evolution of antifreeze glycoprotein gene in northern gadids.

Proc Natl Acad Sci U S A 2019 Feb 14. Epub 2019 Feb 14.

School of Integrative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801

A fundamental question in evolutionary biology is how genetic novelty arises. De novo gene birth is a recently recognized mechanism, but the evolutionary process and function of putative de novo genes remain largely obscure. With a clear life-saving function, the diverse antifreeze proteins of polar fishes are exemplary adaptive innovations and models for investigating new gene evolution. Read More

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http://dx.doi.org/10.1073/pnas.1817138116DOI Listing
February 2019

Mobile platform for rapid sub-picogram-per-milliliter, multiplexed, digital droplet detection of proteins.

Proc Natl Acad Sci U S A 2019 Feb 14. Epub 2019 Feb 14.

School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321;

Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnostics but are currently mainly confined to laboratory settings, due to the instrumentation necessary to serially generate, control, and measure tens of millions of droplets/compartments. To address this challenge, we developed an optofluidic platform that miniaturizes digital assays into a mobile format by parallelizing their operation. Read More

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http://dx.doi.org/10.1073/pnas.1814110116DOI Listing
February 2019

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study.

Lancet 2019 Feb 11. Epub 2019 Feb 11.

AP-HP, Hôpital Cochin, Unité d'Hépatologie, Paris, France; Université Paris Descartes, INSERM U1223 and USM-20, Institut Pasteur, Paris, France.

Background: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort.

Methods: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32111-1DOI Listing
February 2019

Graphene Oxide/Silver Nanoparticle Coating Produced by Electrophoretic Deposition Improved the Mechanical and Tribological Properties of NiTi Alloy for Biomedical Applications.

J Nanosci Nanotechnol 2019 Jul;19(7):3804-3810

College of Advanced Manufacturing Innovations, King Mongkut's Institute of Technology, Ladkrabang, 10520, Thailand.

The aim of this study was to evaluate the mechanical and tribological properties of graphene oxide/silver nanoparticle (GO/AgNP) coated medical grade nickel-titanium (NiTi) alloy. The alloy substrates were coated using electrophoretic deposition at 30 V for 1, 5, and 10 min and were characterized by SEM, Raman spectroscopy, EDS, and surface profilometer. Mechanical and tribological tests were performed for hardness, Young's modulus, and friction coefficient. Read More

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http://dx.doi.org/10.1166/jnn.2019.16327DOI Listing

The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas.

BMC Med 2019 Feb 15;17(1):31. Epub 2019 Feb 15.

Yale University, New Haven, CT, USA.

Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitigate the harmful consequences of health-related stigma (i.e. Read More

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http://dx.doi.org/10.1186/s12916-019-1271-3DOI Listing
February 2019

Realizing the World Health Organization's End TB Strategy (2016⁻2035): How Can Social Approaches to Tuberculosis Elimination Contribute to Progress in Asia and the Pacific?

Trop Med Infect Dis 2019 Feb 5;4(1). Epub 2019 Feb 5.

Melbourne Medical School, The University of Melbourne, Victoria 3010, Australia.

This review article discusses how social approaches to tuberculosis elimination might contribute to realizing the targets stipulated in the World Health Organization's (WHO) End TB Strategy (2016⁻2035), with an emphasis on opportunities for progress in Asia and the Pacific. Many factors known to advance tuberculosis transmission and progression are pervasive in Asia and the Pacific, such as worsening drug resistance, unregulated private sector development, and high population density. This review article argues that social solutions must be revisited and improved upon if current worldwide tuberculosis rates are to be sustainably reduced in the long term. Read More

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http://dx.doi.org/10.3390/tropicalmed4010028DOI Listing
February 2019

Determining Best Practices for Management of Bacteriuria in Spinal Cord Injury: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2019 Feb 14;8(2):e12272. Epub 2019 Feb 14.

Center for Innovations in Quality, Effectiveness and Safety, Houston, TX, United States.

Background: Bacteriuria, either asymptomatic (ASB) or symptomatic, urinary tract infection (UTI), is common in persons with spinal cord injury (SCI). Current Veterans Health Administration (VHA) guidelines recommend a screening urinalysis and urine culture for every veteran with SCI during annual evaluation, even when asymptomatic, which is contrary to other national guidelines. Our preliminary data suggest that a positive urine culture (even without signs or symptoms of infection) drives antibiotic use. Read More

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https://www.researchprotocols.org/2019/2/e12272/
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http://dx.doi.org/10.2196/12272DOI Listing
February 2019
2 Reads

Evaluation of a Bystander-Focused Interpersonal Violence Prevention Program with High School Students.

Prev Sci 2019 Feb 14. Epub 2019 Feb 14.

Tufts Medical Center, Institute for Clinical Research and Health Policy Studies, Boston, MA, USA.

This study evaluated the effectiveness of a seven-session, bystander-focused, classroom-delivered curriculum (i.e., Bringing in the Bystander-High School Curriculum [BITB-HSC]) in reducing rates of interpersonal violence among high school students. Read More

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http://dx.doi.org/10.1007/s11121-019-01000-wDOI Listing
February 2019

A Phylogenetic Study of the ANT Family Points to a preANT Gene as the Ancestor of Basal and euANT Transcription Factors in Land Plants.

Front Plant Sci 2019 29;10:17. Epub 2019 Jan 29.

Molecular and Developmental Complexity Group, Unidad de Genómica Avanzada, Laboratorio Nacional de Genómica para la Biodiversidad, Centro de Investigación y de Estudios Avanzados del IPN, Guanajuato, Mexico.

Comparative genomics has revealed that members of early divergent lineages of land plants share a set of highly conserved transcription factors (TFs) with flowering plants. While gene copy numbers have expanded through time, it has been predicted that diversification, co-option, and reassembly of gene regulatory networks implicated in development are directly related to morphological innovations that led to more complex land plant bodies. Examples of key networks have been deeply studied in , such as those involving the AINTEGUMENTA (ANT) gene family that encodes AP2-type TFs. Read More

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http://dx.doi.org/10.3389/fpls.2019.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361745PMC
January 2019

Auditory Brainstem Implants: Recent Progress and Future Perspectives.

Front Neurosci 2019 29;13:10. Epub 2019 Jan 29.

Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, United States.

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the following review are to describe the history of the ABI and innovations leading up to the modern ABI system, as well as highlight areas of future development in implant design. Read More

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http://dx.doi.org/10.3389/fnins.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361749PMC
January 2019

Rolling of the jaw is essential for mammalian chewing and tribosphenic molar function.

Nature 2019 Feb 13. Epub 2019 Feb 13.

Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA.

Over the past two centuries, mammalian chewing and related anatomical features have been among the most discussed of all vertebrate evolutionary innovations. Chief among these features are two characters: the dentary-only mandible, and the tribosphenic molar with its triangulated upper cusps and lower talonid basin. The flexible mandibular joint and the unfused symphysis of ancestral mammals-in combination with transformations of the adductor musculature and palate-are thought to have permitted greater mobility of each lower jaw, or hemimandible. Read More

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http://dx.doi.org/10.1038/s41586-019-0940-xDOI Listing
February 2019

A 12-kb structural variation in progressive myoclonic epilepsy was newly identified by long-read whole-genome sequencing.

J Hum Genet 2019 Feb 13. Epub 2019 Feb 13.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.

We report a family with progressive myoclonic epilepsy who underwent whole-exome sequencing but was negative for pathogenic variants. Similar clinical courses of a devastating neurodegenerative phenotype of two affected siblings were highly suggestive of a genetic etiology, which indicates that the survey of genetic variation by whole-exome sequencing was not comprehensive. To investigate the presence of a variant that remained unrecognized by standard genetic testing, PacBio long-read sequencing was performed. Read More

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http://dx.doi.org/10.1038/s10038-019-0569-5DOI Listing
February 2019

A Seat at the Table.

J Am Acad Psychiatry Law 2019 Feb 13. Epub 2019 Feb 13.

Dr. Thompson is Associate Clinical Professor of Psychiatry in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA in Los Angeles, California.

Organized medicine and psychiatry have a long tradition of governmental advocacy and public engagement. The American Academy of Psychiatry and the Law (AAPL), since its founding 50 years ago, has made some forays into these fields. However, its involvement has been less substantial than other similarly situated professional organizations. Read More

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http://dx.doi.org/10.29158/JAAPL.003812-19DOI Listing
February 2019

Minimally Invasive Surgical Aortic Valve Replacement: An Overview of Recent Advances.

Can J Cardiol 2019 Feb 4;35(2):225-228. Epub 2018 Dec 4.

Section of Cardiac Surgery, Division of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Aortic valve replacement (AVR) is the only definitive treatment for severe aortic stenosis. Options for valve replacement include surgical AVR (SAVR) and percutaneous transcatheter AVR. Although transcatheter AVR has recently been shown to be the optimal approach for high-risk patients, SAVR is the gold standard for patients with low and intermediate surgical risk. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.027DOI Listing
February 2019

Traveling health-promoting infrastructures: A meta-ethnographic analysis.

Health (London) 2019 Feb 13:1363459319829195. Epub 2019 Feb 13.

University of Copenhagen, Denmark.

In recent years, it has become increasingly important to understand the global circulation of healthcare innovations in nations' attempts to solve contemporary health challenges. This article is a systematic review and meta-ethnography-inspired analysis that explores the global circulation of health-related standards, protocols, procedures, and regulations, or what we term health-promoting infrastructures (HPIs). The notion of HPIs is defined as built networks that allow for the circulation of health expertise with the intention of promoting solutions that address global health problems. Read More

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http://dx.doi.org/10.1177/1363459319829195DOI Listing
February 2019

A Knowledge-Driven Approach for 3D High Temporal-Spatial Measurement of an Arbitrary Contouring Error of CNC Machine Tools Using Monocular Vision.

Sensors (Basel) 2019 Feb 12;19(3). Epub 2019 Feb 12.

Key Laboratory for Precision and Non-traditional Machining Technology of the Ministry of Education, Dalian University of Technology, Dalian 116024, China.

Periodic health checks of contouring errors under unloaded conditions are critical for machine performance evaluation and value-added manufacturing. Aiming at breaking the dimension, range and speed measurement limitations of the existing devices, a cost-effective knowledge-driven approach for detecting error motions of arbitrary paths using a single camera is proposed. In combination with the PNP algorithm, the three-dimensional (3D) evaluation of large-scale contouring error in relatively high feed rate conditions can be deduced from a priori geometrical knowledge. Read More

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http://dx.doi.org/10.3390/s19030744DOI Listing
February 2019

A bibliometric and network analysis of Lean and Clean(er) production research (1990/2017).

Sci Total Environ 2019 Feb 2;653:765-775. Epub 2018 Nov 2.

University of Messina, Department of Economics, Piazza Pugliatti 1, 98122 Messina, Italy.

In recent years, the renewed interest in environmental issues has gradually required manufacturers to simultaneously pursue a more rational use of resources and a reduction in wastes production. New strategies, technologies and organisational innovations must be therefore conceived to "create more value with less impact" (WBCSD, 2010). An interesting and promising perspective for achieving internal efficiency, market effectiveness and environmental eco-efficiency is that of integrating the environmental variable in the Lean Production (LP) paradigm. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.412DOI Listing
February 2019

Evidences of copper nanoparticle exposure in indoor environments: Long-term assessment, high-resolution field emission scanning electron microscopy evaluation, in silico respiratory dosimetry study and possible health implications.

Sci Total Environ 2019 Feb 6;653:1192-1203. Epub 2018 Nov 6.

Department of Chemistry, Sapienza University, P.le Aldo Moro 5, I-00185 Rome, Italy.

A variety of appliances operated by brush electric motors, widely used in indoor environments, emit nanoparticles (NPs). Due to electric arc discharge during the operation of such motors, some NPs contain copper (Cu). Their dimensions are the same of those found in brain tissue samples by other authors who speculated their possible translocation to brain through olfactory bulb. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.044DOI Listing
February 2019

Use of non-insulin diabetes medicines after insulin initiation: A retrospective cohort study.

PLoS One 2019 13;14(2):e0211820. Epub 2019 Feb 13.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Background: Clinical guidelines recommend that metformin be continued after insulin is initiated among patients with type 2 diabetes, yet little is known regarding how often metformin or other non-insulin diabetes medications are continued in this setting.

Methods: We conducted a retrospective cohort study to characterize rates and use patterns of six classes of non-insulin diabetes medications: biguanides (metformin), sulfonylureas, thiazolidinediones (TZDs), glucagon-like peptide 1 receptor agonists (GLP1 receptor agonists), dipeptidyl peptidase 4 inhibitors (DPP4 inhibitors), and sodium-glucose co-transporter inhibitors (SGLT2 inhibitors), among patients with type 2 diabetes initiating insulin. We used the 2010-2015 MarketScan Commercial Claims and Encounters data examining 72,971 patients with type 2 diabetes aged 18-65 years old who initiated insulin and had filled a prescription for a non-insulin diabetes medication in the 90 days prior to insulin initiation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211820PLOS
February 2019

[Evidence-based surgery of rectal cancer].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

Over the past four decades, the treatment algorithms for rectal cancer have fundamentally changed, which resulted in a considerable improvement of oncological outcomes. In this context, the surgical concept of total mesorectal excision and the implementation of multimodal treatment strategies represent key milestones. These improvements were complemented by a standardized histopathological work-up of the surgical specimen and the introduction of high-resolution magnetic resonance imaging (MRI) diagnostics. Read More

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http://dx.doi.org/10.1007/s00104-019-0802-yDOI Listing
February 2019

Multishelled Transition Metal-Based Microspheres: Synthesis and Applications for Batteries and Supercapacitors.

Small 2019 Feb 13:e1804737. Epub 2019 Feb 13.

State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Linggong Road 2#, Dalian, 116024, China.

With the rapid growth of material innovations, multishelled hollow nanostructures are of tremendous interest due to their unique structural features and attractive physicochemical properties. Continued effort has been made in the geometric manipulation, composition complexity, and construction diversity of this material, expanding its applications. Energy storage technology has benefited from the large surface area, short transport path, and excellent buffering ability of the nanostructures. Read More

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http://doi.wiley.com/10.1002/smll.201804737
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http://dx.doi.org/10.1002/smll.201804737DOI Listing
February 2019
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Breath analysis by two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection - Method optimisation and integration within a large-scale clinical study.

J Chromatogr A 2019 Feb 5. Epub 2019 Feb 5.

Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. Electronic address:

Precision medicine has spurred new innovations in molecular pathology leading to recent advances in the analysis of exhaled breath as a non-invasive diagnostic tool. Volatile organic compounds (VOCs) detected in exhaled breath have the potential to reveal a wealth of chemical and metabolomic information. This study describes the development of a method for the analysis of breath, based on automated thermal desorption (TD) combined with flow modulated comprehensive two-dimensional gas chromatography (GC×GC) with dual flame ionisation and quadrupole mass spectrometric detection (FID and qMS). Read More

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http://dx.doi.org/10.1016/j.chroma.2019.02.001DOI Listing
February 2019

The role of scientific evidence in decisions to adopt complex innovations in cancer care settings: a multiple case study in Nova Scotia, Canada.

Implement Sci 2019 Feb 12;14(1):14. Epub 2019 Feb 12.

Department of Surgery, Dalhousie University, Room 8-032, Centennial Building, 1276 South Park Street, Halifax, Nova Scotia, B3H 2Y9, Canada.

Background: Health care delivery and outcomes can be improved by using innovations (i.e., new ideas, technologies, and practices) supported by scientific evidence. Read More

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http://dx.doi.org/10.1186/s13012-019-0859-5DOI Listing
February 2019

Memory B-cells and Long-Lived Plasma Cells.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

University of Alberta.

The importance of B-cell and antibody-mediated immune response in the acute and long-term persistence of transplanted solid organs has become increasingly evident in recent years. A variety of therapeutic innovations target antibodies directed towards human leucocyte antigens (HLA) or blood groups (ABO) in order to allow better allocation and post-transplant longevity of organs. Antibodies originate from plasma cells, which are terminally differentiated B-cells. Read More

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http://dx.doi.org/10.1097/TP.0000000000002594DOI Listing
February 2019

New developments in rabies vaccination.

Rev Sci Tech 2018 Aug;37(2):657-672

Current rabies vaccines are safe and, when administered properly, they are highly effective. In addition, they elicit long-lasting immunity, with virus-neutralising antibody titres persisting for years after vaccination. However, current regimens require multiple doses to achieve high neutralising titres and they are costly, which means that it is difficult for developing countries, where rabies deaths are highest, to implement widespread vaccination. Read More

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http://dx.doi.org/10.20506/rst.37.2.2831DOI Listing

Public health issues in the 21st century: National challenges and shared challenges for the Maghreb countries.

Tunis Med 2018 Oct-Nov;96(10-11):847-857

In the 21st century, public health is not only about fighting infectious diseases, but also contributing to a "multidimensional" well-being of people (health promotion, non-communicable diseases, the role of citizens and people in the health system etc.). Six themes of public health, issues of the 21st century will be addressed. Read More

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February 2019