24,924 results match your criteria Innovations Philadelphia Pa.[Journal]


"Platelet-rich plasma and its utility in medical dermatology - A systematic review".

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Johns Hopkins University, Baltimore, Maryland.

The field of dermatology has seen numerous therapeutic innovations in the past decade with platelet-rich plasma (PRP) recently garnering significant interest particularly in alopecia, acne scarring and skin rejuvenation. In other conditions of dermatology, such as chronic wounds and vitiligo, PRP has been investigated but has received less attention. The objective of this literature review was to focus on conditions of medical dermatology and to consolidate the available evidence of platelet-rich plasma for the practicing dermatologist. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.037DOI Listing

Modified GoPro Hero 6 and 7 for Intraoperative Surgical Recording-Transformation Into a Surgeon-Perspective Professional Quality Recording System.

J Oral Maxillofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Chief, Division of Head and Neck Surgery; Program Director, Head and Neck Oncologic Surgery and Microvascular Fellowship; Associate Department Chair and Professor, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Recent innovations in wearable action cameras with high-definition video recording enable surgeons to use cameras for their surgical procedures. In this study, the GoPro HERO 6 (and 7) Black edition camera was modified step by step to allow for a completely wireless surgeon-perspective recording with a battery life and memory capacity never previously obtained with such a high level of digital video quality. With this system, a surgeon can record for more than 14 hours 26 minutes in 1,080 pixels at 60 frames per second without breaking scrub and capture the operating surgeon's direct view of the field. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.026DOI Listing

Tissue Clearing and Its Application to Bone and Dental Tissues.

J Dent Res 2019 Apr 22:22034519844510. Epub 2019 Apr 22.

1 Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.

Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Read More

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http://dx.doi.org/10.1177/0022034519844510DOI Listing

Machine Learning and Deep Neural Networks in Thoracic and Cardiovascular Imaging.

J Thorac Imaging 2019 May;34(3):192-201

Department of Radiology, University of California San Diego.

Advances in technology have always had the potential and opportunity to shape the practice of medicine, and in no medical specialty has technology been more rapidly embraced and adopted than radiology. Machine learning and deep neural networks promise to transform the practice of medicine, and, in particular, the practice of diagnostic radiology. These technologies are evolving at a rapid pace due to innovations in computational hardware and novel neural network architectures. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000385DOI Listing

Standing on the Shoulders of Giants: Innovations in Dialysis.

Nephrol Nurs J 2019 Mar-Apr;46(2):223-233

Renal and Transplant Clinical Nurse Specialist, the University of Washington Medical Center, Seattle, WA.

Prior to the 1960s, chronic hemodialysis was limited by vascular access. Pioneers in dialysis technology created the first artificial kidney, chronic vascular access for hemodialysis, and peritoneal dialysis access. Now it is estimated that 600,000 people in the United States and over 2 million people worldwide receive renal replacement therapy. Read More

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iCanCope PostOp: User-Centered Design of a Smartphone-Based App for Self-Management of Postoperative Pain in Children and Adolescents.

JMIR Form Res 2019 Apr 22;3(2):e12028. Epub 2019 Apr 22.

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Moderate to severe postoperative pain in children is common. Increased pediatric day surgeries have shifted postoperative pain management predominantly to the home setting. Mobile health technology has the potential to overcome barriers to pain care by improving access to self-management resources. Read More

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http://dx.doi.org/10.2196/12028DOI Listing

Introduction to the JPO special issue: Innovations and real world applications of relationship research in cancer.

J Psychosoc Oncol 2019 Mar-Apr;37(2):127-130

b Cancer Prevention and Control Program , Fox Chase Cancer Center , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/07347332.2019.1579887DOI Listing

A History of Innovations in the Diagnosis and Treatment of Oral and Head and Neck Cancer.

J Dent Res 2019 May;98(5):489-497

4 Department of Pathology, University of Chicago, Chicago, IL, USA.

Historical records as far back as 3000 BCE show that oral and head and neck cancer was a disease process well known to Egyptian physicians. Luminaries such as Hippocrates, Galen, Pott, and Virchow were instrumental in shaping our understanding of the etiology and pathogenesis of cancer. During the 20th century, evidence-based medicine catalyzed the development of rigorous science-based diagnostic and treatment protocols. Read More

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http://dx.doi.org/10.1177/0022034519833645DOI Listing

Overreliance on Cost Reduction as a Featured Element of Sensor Design.

ACS Sens 2019 Apr 22. Epub 2019 Apr 22.

In this perspective, we examine the role of cost in sensor design, its meaning within the context of converting academic prototypes into commercial products, and the importance of these issues to clear scientific communication. The possible motivations to consider the cost of a technology, sensor, or assay are both numerous and apparent. However, the idea that the cost of reagents and materials at the laboratory scale will directly translate to the purchase price for a user is inaccurate. Read More

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http://dx.doi.org/10.1021/acssensors.9b00260DOI Listing

Expert Group Meeting on Aphasia: A Report.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):137-146

Aphasia Research Center, Maryland, USA.

A multidisciplinary team of experts took stock of the current state of affairs about many aspects of aphasia in India, including community burden, diagnostic assessment, therapy, rehabilitation, research, education, and advocacy. The broad spectrum of aphasiology was matched by the types of participants ranging from neurologists, speech-language pathologists, clinical psychologists, linguists, to experts in neuroimaging and computer sciences. Threadbare discussion in 16 sessions over 3 days leads to the identification of pressing problems and possible solutions. Read More

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http://dx.doi.org/10.4103/aian.AIAN_330_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472241PMC

Energy and environmental assessment of a traction lithium-ion battery pack for plug-in hybrid electric vehicles.

J Clean Prod 2019 Apr;215:634-649

European Commission, Joint Research Centre, Directorate for Energy, Transport and Climate, Energy Storage Unit, Westerduinweg 3, NL-1755 LE, Petten, the Netherlands.

Traction batteries are a key factor in the environmental sustainability of electric mobility and, therefore, it is necessary to evaluate their environmental performance to allow a comprehensive sustainability assessment of electric mobility. This article presents an environmental assessment of a lithium-ion traction battery for plug-in hybrid electric vehicles, characterized by a composite cathode material of lithium manganese oxide (LiMnO) and lithium nickel manganese cobalt oxide Li(NiCoMn)O. Composite cathode material is an emerging technology that promises to combine the merits of several active materials into a hybrid electrode to optimize performance and reduce costs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09596526193006
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http://dx.doi.org/10.1016/j.jclepro.2019.01.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472661PMC
April 2019
1 Read

Temperature-dependent irreversible conformational change of recombinant ADAMTS13 upon metal ion chelation.

J Thromb Haemost 2019 Apr 21. Epub 2019 Apr 21.

Baxalta Innovations GmbH, a member of the Takeda group of companies, Vienna, Austria.

Background: The catalytic domain of ADAMTS13 possesses one Zn and up to three putative Ca binding sites and can be inactivated by chelating agents. Although replenishment with an appropriate metallic cation is thought to restore the enzyme's proteolytic activity fully, ADAMTS13 stability in a metal ion-depleting environment has not been explored.

Objectives: To address the stability of ADAMTS13 in citrated human plasma. Read More

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http://dx.doi.org/10.1111/jth.14440DOI Listing

School-Age Children Can Recall Some Foods and Beverages Consumed the Prior Day Using the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) without Assistance.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

School of Public Health and Health Systems, University of Waterloo, Waterloo, ON, Canada.

Background: Technological innovations allow for collection of 24-h recalls (24HRs) in a broader range of studies than previously possible. The web-based Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) has been shown to be feasible and to perform well in capturing true intake among adults. However, data to inform use with children are limited. Read More

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http://dx.doi.org/10.1093/jn/nxz013DOI Listing

Where Do Ultrafine Particles and Nano-Sized Particles Come From?

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Agricultural, Environmental and Food Sciences (DiAAA), University of Molise, Campobasso, Italy.

This paper presents an overview of the literature studies on the sources of ultrafine particles (UFPs), nanomaterials (NMs), and nanoparticles (NPs) occurring in indoor (occupational and residential) and outdoor environments. Information on the relevant emission factors, particle concentrations, size, and compositions is provided, and health relevance of UFPs and NPs is discussed. Particular attention is focused on the fraction of particles that upon inhalation deposit on the olfactory bulb, because these particles can possibly translocate to brain and their possible role in neurodegenerative diseases is an important issue emerging in the recent literature. Read More

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http://dx.doi.org/10.3233/JAD-181266DOI Listing

Applying Interdisciplinary Innovations to Advance Theories of Social Behavior: Response to Van Dessel and Colleagues.

Authors:
David M Amodio

Trends Cogn Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychology, New York University, New York, NY 10003, USA; Department of Psychology, University of Amsterdam, Nieuwe Achtergracht 129B, 1018, WT, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tics.2019.03.004DOI Listing

The role of renewable energy, immigration and real income in environmental sustainability target. Evidence from Europe largest states.

Sci Total Environ 2019 Apr 13;674:307-315. Epub 2019 Apr 13.

Faculty of Business and Economics, Department of Economics, Eastern Mediterranean University, via Mersin 10, Famagusta, North Cyprus, Turkey. Electronic address:

In spite of the continued deployment of technologies, innovations toward addressing the challenges of global warming, forecasting and sustaining quality environment have remained the herculean endeavour of the advanced states. Also, being migrants' destinations, resulting from the availability of economic opportunities, the target of attaining low-carbon, energy efficiency, and the cleaner atmospheric environment by these advanced economies is further bewildered. In that light, we investigate the impact of renewable energy consumption and migration on the carbon dioxide emissions of the panel of European Union's largest economies of France, Germany, and the United Kingdom over the period of 1990-2016. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.163DOI Listing

Can innovations in traditional pork products help thriving EU untapped pig breeds? A non-hypothetical discrete choice experiment with hedonic evaluation.

Meat Sci 2019 Apr 11;154:75-85. Epub 2019 Apr 11.

CREDA-UPC-IRTA, Centre for Agro-food Economy & Development, Castelldefels, Spain.

The EU is supporting measures that stimulate enhanced value-added products in order to conserve local and threatened livestock breeds. Several Traditional Pork Products (TPP) and Innovative Traditional Pork Products (ITPP) with health innovations from four untapped pig breeds in Spain (Porc Negre Mallorquí), Croatia (Turopolje), Italy (Cinta Senese) and Slovenia (Krškopolje) were analysed. Consumers' "Non-hypothetical" willingness to pay (WTP) and hedonic evaluation were investigated. Read More

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http://dx.doi.org/10.1016/j.meatsci.2019.04.011DOI Listing

Integration of biological systems with electronic-mechanical assemblies.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA; Department of Engineering Science and Mechanics, and Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. Electronic address:

Biological systems continuously interact with the surrounding environment because they are dynamically evolving. The interaction is achieved through mechanical, electrical, chemical, biological, thermal, optical, or a synergistic combination of these cues. To provide a fundamental understanding of the interaction, recent efforts that integrate biological systems with the electronic-mechanical assemblies create unique opportunities for simultaneous monitoring and eliciting the responses to the biological system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.032DOI Listing
April 2019
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Statistical optimization of glyphosate adsorption by biochar and activated carbon with response surface methodology.

Chemosphere 2019 Apr 11;227:533-540. Epub 2019 Apr 11.

Environmental Bio-innovations Group (EBiG), School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. Electronic address:

The introduction of glyphosate, found in herbicides, to waterbodies is of concern due to its toxicity and hence potential threat to public health and ecological systems. The present study has compared glyphosate removal from aqueous solution with activated carbon and biochar. Box-Behnken design, and percent contribution with Pareto analysis techniques were used in surface response and efficiency calculations modelled the process conditions and their effects. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.078DOI Listing

Come Dance With Me: Transformative Changes in the Science and Practice of Drug-Drug Interactions.

Clin Pharmacol Ther 2019 Apr 20. Epub 2019 Apr 20.

Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.

The past 2 decades have witnessed transformative changes in our approach to drug-drug interactions (DDIs) from scientific research to clinical practice. Collaborative cooperation across the sectors of academia, pharmaceutical industry, providers of translational research tools and services, global regulatory agencies, and healthcare providers has created and galvanized a science-informed and patient-centered approach. Multidisciplinary innovations in mechanistic assessment of absorption, distribution, metabolism, and excretion (ADME), population pharmacology and pharmacogenetics, physiologically based modeling, and regulatory science have enabled a profound shift in mindset from risk aversion to informative prescribing guidance for optimal risk management. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1433
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http://dx.doi.org/10.1002/cpt.1433DOI Listing
April 2019
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Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non-Small Cell Lung Cancer.

CPT Pharmacometrics Syst Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Iowa State University College of Veterinary Medicine, Ames, IA, U.S.A.

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/psp4.12415
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http://dx.doi.org/10.1002/psp4.12415DOI Listing
April 2019
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Discontinuation Rates of Antidepressant Use by Dutch Soldiers.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, PO Box 80082 3508 TB Utrecht, The Netherlands.

Introduction: Soldiers have a higher risk for developing psychiatric disorders that require treatment; often with antidepressants. However, antidepressants as well as the psychiatric disorder, may influence military readiness in several ways. In the general population, early discontinuation of antidepressant treatment is often seen. Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz060DOI Listing
April 2019
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Flow Restrictors and Reduction of Accidental Ingestions of Over-the-Counter Medications.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado; Inflexxion, Inc., Waltham, Massachusetts.

Introduction: Flow restrictors are child-resistant packaging innovations designed to limit the amount of liquid dispensed from a medication bottle. In 2011, flow restrictors were added to pediatric liquid single-ingredient acetaminophen formulations. The hypothesis of this study is that implementation would be associated with reduced volume and severity of pediatric acetaminophen exposures reported to the U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193004
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http://dx.doi.org/10.1016/j.amepre.2018.12.015DOI Listing
April 2019
1 Read

Taking Care of the Dyad: Frequency of Caregiver Assessment Among Veterans with Dementia.

J Am Geriatr Soc 2019 Apr 19. Epub 2019 Apr 19.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.

Objectives: This study assessed frequency of caregiver identification and needs of a sample of persons with dementia (PWDs) and their caregivers to determine whether needs were addressed and whether documentation increased with growing levels of self-reported relationship problems and burden.

Design: Cross-sectional design using data from electronic medical record (EMR) review and baseline research assessments (Burden Interview and Mutuality Scale). Items from a caregiver assessment tool were used to identify documentation of important factors in clinical guidelines. Read More

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http://dx.doi.org/10.1111/jgs.15882DOI Listing
April 2019
2 Reads

Tools and Approaches for Dissecting Protein Bacteriocin Import in Gram-Negative Bacteria.

Front Microbiol 2019 28;10:646. Epub 2019 Mar 28.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

Bacteriocins of Gram-negative bacteria are typically multi-domain proteins that target and kill bacteria of the same or closely related species. There is increasing interest in protein bacteriocin import; from a fundamental perspective to understand how folded proteins are imported into bacteria and from an applications perspective as species-specific antibiotics to combat multidrug resistant bacteria. In order to translocate across the cell envelope and cause cell death, protein bacteriocins hijack nutrient uptake pathways. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00646
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http://dx.doi.org/10.3389/fmicb.2019.00646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455109PMC
March 2019
2 Reads

Motor sequence learning and pattern recognition in youth at clinical high-risk for psychosis.

Schizophr Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychology, Northwestern University, Evanston, IL, USA; Department of Psychiatry, Northwestern University, Chicago, IL, USA; Medical Social Sciences, Northwestern University, Chicago, IL, USA; Institute for Policy Research (IPR), Northwestern University, Chicago, IL, USA; Institute for Innovations in Developmental Sciences (DevSci), Northwestern University, Evanston and Chicago, IL, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193011
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http://dx.doi.org/10.1016/j.schres.2019.03.023DOI Listing
April 2019
1 Read

Health and immunisation services for the urban poor in selected countries of Asia.

Infect Dis Poverty 2019 Apr 18;8(1):26. Epub 2019 Apr 18.

UNICEF Headquarter, New York, USA.

Background: Asia is a region that is rapidly urbanising. While overall urban health is above rural health standards, there are also pockets of deep health and social disadvantage within urban slum and peri-urban areas that represent increased public health risk. With a focus on vaccine preventable disease and immunisation coverage, this commentary describes and analyses strengths and weaknesses of existing urban health and immunisation strategy, with a view to recommending strategic directions for improving access to immunisation and related maternal and child health services in urban areas across the region. Read More

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https://idpjournal.biomedcentral.com/articles/10.1186/s40249
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http://dx.doi.org/10.1186/s40249-019-0538-4DOI Listing
April 2019
1 Read

Novel approaches to estimating abortion incidence.

Reprod Health 2019 Apr 18;16(1):44. Epub 2019 Apr 18.

Guttmacher Institute, 125 Maiden Lane 7th Floor, New York, NY, 10038, USA.

Background: In countries where abortion is legally restricted or clandestine, estimates of abortion incidence are needed in order to bring attention to the reality of this practice. Innovations in methods for estimating stigmatized behaviors, coupled with changes in the conditions under which women obtain abortions, prompt us to review new approaches to estimating abortion incidence and propose innovations in this field.

Methods: We discuss five approaches for yielding accurate estimates in countries with restrictive abortion laws. Read More

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http://dx.doi.org/10.1186/s12978-019-0702-0DOI Listing

Resilience in the midst of chaos: Socioecological model applied to women with depressive symptoms and socioeconomic disadvantage.

J Community Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York.

Socioeconomic disadvantage is extremely common among women with depressive symptoms presenting for women's health care. While social stressors related to socioeconomic disadvantage can contribute to depression, health care tends to focus on patients' symptoms in isolation of context. Health care providers may be more effective by addressing issues related to socioeconomic disadvantage. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcop.22188
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http://dx.doi.org/10.1002/jcop.22188DOI Listing
April 2019
2 Reads

Dietary inflammatory index is positively associated with serum high-sensitivity C-reactive protein in a Korean adult population.

Nutrition 2018 Nov 23;63-64:155-161. Epub 2018 Nov 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA; Connecting Health Innovations LLC, Columbia, South Carolina, USA.

Objective: To our knowledge, only a few studies have explored the relationship between the inflammatory potential of diet and serum inflammatory markers in Korean adults. The likely novel aim of this study was to examine the association between the dietary inflammatory index (DII) and serum high-sensitivity C-reactive protein (hs-CRP) in a Korean adult population.

Methods: A cross-sectional study was conducted using the data set from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.016DOI Listing
November 2018

SQUIRE-EDU (Standards for QUality Improvement Reporting Excellence in Education): Publication Guidelines for Educational Improvement.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

G. Ogrinc is senior associate dean for medical education, and professor of medicine, the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. G.E. Armstrong is associate professor, University of Colorado College of Nursing, Aurora, Colorado. M.A. Dolansky is associate professor, Case Western Reserve University, Frances Payne Bolton School of Nursing, and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. M.K .Singh is assistant dean, Health Systems Science, and associate professor of medicine, Case Western Reserve University School of Medicine and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. L. Davies is associate professor, Section of Otolaryngology-Head & Neck Surgery, and the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; and associate professor, Department of Veterans Affairs Medical Center, White River Junction, Vermont.

The SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence) guidelines were published in 2015 to increase the completeness, precision, and transparency of published reports about efforts to improve the safety, value, and quality of health care. The principles and methods applied in work to improve health care are often applied in educational improvement as well. Read More

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http://dx.doi.org/10.1097/ACM.0000000000002750DOI Listing
April 2019
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Remote login software and other innovations to enhance scale-up of point-of-care HPV testing in high-burden, low-income settings.

Authors:
Steven Badman

J Virus Erad 2019 Mar 4;5(Suppl 1):4-5. Epub 2019 Mar 4.

Kirby Institute, University of New South Wales, Sydney, Australia.

Molecular diagnosis of HPV at the point of care (POC) is an important technological development because the highest rates of HPV infection are often found in low-resource settings (LRS) or very remote locations in high-resource settings (HRS). The burden of HPV-related morbidity and mortality in LRS is high and requires immediate action in order to be contained or eliminated. However, accurate estimates of prevalence and risk factors are not available in many countries, and current HPV testing capacity varies considerably. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428154PMC

Flow field perception based on the fish lateral line system.

Bioinspir Biomim 2019 Apr 17. Epub 2019 Apr 17.

Beihang University, Beijing, CHINA.

Fish are able to perceive the surrounding weak flow and pressure variations with their mechanosensory lateral line system, which consists of a superficial lateral line for flow velocity detection and a canal lateral line for flow pressure gradient perception. Achieving a better understanding of the flow field perception algorithms of the lateral line can contribute not only to the design of highly sensitive flow sensors, but also to the development of underwater smart skin with good hydrodynamic imaging properties. In this review, we discuss highly sensitive flow-sensing mechanisms for superficial and canal neuromasts and flow field perception algorithms. Read More

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http://dx.doi.org/10.1088/1748-3190/ab1a8dDOI Listing
April 2019
1 Read

Potential Technologies Review - A hybrid information retrieval framework to accelerate demand-pull innovation in biomedical engineering.

Res Synth Methods 2019 Apr 17. Epub 2019 Apr 17.

Science Management, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.

Launching biomedical innovations based on clinical demands instead of translating basic research findings to practice reduces the risk that the results will not fit the clinical routine. To realize this type of innovation, a meta-analysis of the body of research is necessary to reveal demand-matching concepts. However, both the data deluge and the narrow time constraints for innovation make it impossible to perform such reviews manually. Read More

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http://dx.doi.org/10.1002/jrsm.1350DOI Listing

The Status and Impact of Clinical Tumor Genome Sequencing.

Annu Rev Genomics Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

Khalifa Bin Zayed Institute for Personalized Cancer Therapy and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; email:

Since the discovery that DNA alterations initiate tumorigenesis, scientists and clinicians have been exploring ways to counter these changes with targeted therapeutics. The sequencing of tumor DNA was initially limited to highly actionable hot spots-areas of the genome that are frequently altered and have an approved matched therapy in a specific tumor type. Large-scale genome sequencing programs quickly developed technological improvements that enabled the deployment of whole-exome and whole-genome sequencing technologies at scale for pristine sample materials in research environments. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015034DOI Listing

[A strategic roadmap of the Italian Society of Interventional Cardiology (SICI-GISE) to ensure patient's access to appropriate treatment].

G Ital Cardiol (Rome) 2019 Apr;20(4):4-19

A.O. Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna.

In comparison with the international scenario, in Italy the penetration of several important scientific and technological innovations in the field of cardiovascular intervention appears to be inadequate both in terms of number of patients treated with respect to the actual need, and inhomogeneity between the different geographical areas of the country. One of the main institutional objectives of the Italian Society of Interventional Cardiology (SICI-GISE) is to develop a roadmap to guarantee homogeneous access throughout the whole national territory to treatments that are recommended by the major international guidelines. The present document focuses on four main areas of cardiovascular intervention: (i) transcatheter treatment of aortic valve stenosis, (ii) percutaneous mitral valve repair, (iii) prevention of cardioembolic stroke through percutaneous left atrial appendage occlusion in patients with non-valvular atrial fibrillation, (iv) optimization of coronary revascularization with the aid of the functional study of coronary lesions. Read More

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http://dx.doi.org/10.1714/3146.31274DOI Listing
April 2019
3 Reads

An evaluation of an early stage innovation for full-thickness excision of benign colonic polyps using the IDEAL framework.

Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, St Mark's Hospital, Harrow, Middlesex, UK.

Aims: Colectomy is the current approach for patients with endoscopically unresectable benign polyps but risks considerable morbidity. Full-thickness laparoendoscopic excision(FLEX) is a novel, specifically developed procedure which could reduce this treatment burden and improve outcomes. However, traditional evaluations of surgical innovations have lacked methodological rigour. Read More

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http://dx.doi.org/10.1111/codi.14650DOI Listing
April 2019
1 Read

Drafting eligible biotech and immunotherapy claims.

Authors:
Shyh-Jen Wang

Hum Vaccin Immunother 2019 Apr 16. Epub 2019 Apr 16.

a Taipei Veterans General Hospital , Tiapei , Taiwan Taiwan.

The very recent US Supreme Court and Court of Appeals for Federal Circuit (CAFC) cases have dramatically changed the standard of patent eligibility. Several groundbreaking innovations were thus determined to be patent ineligible. The patent ineligibility would impact on the innovation s of the field of biomarkers, diagnostic methods and personalize cancer immunotherapy. Read More

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http://dx.doi.org/10.1080/21645515.2019.1608746DOI Listing

Off-Label High-Dose Secukinumab for the Treatment of Moderate-to-Severe Psoriasis.

J Cutan Med Surg 2019 Apr 16:1203475419843118. Epub 2019 Apr 16.

7 Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Secukinumab is an anti-IL-17A monoclonal antibody approved for the treatment of moderate-to-severe psoriasis in adult patients. Despite its favourable safety and efficacy profile in clinical trials, some patients in clinical practice fail to respond adequately to the approved maintenance regimen of 300 mg subcutaneous monthly. Some clinicians manage these patients by using off-label high-dose secukinumab regimens, which include shortening the dosing interval to 300 mg every 2 or 3 weeks instead of monthly, or increasing the monthly dose to 450 mg. Read More

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http://dx.doi.org/10.1177/1203475419843118DOI Listing
April 2019
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In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity.

Molecules 2019 Apr 15;24(8). Epub 2019 Apr 15.

Graduate Program of Pharmaceutical Innovation, Federal University of Amapá, Macapá-AP 68902-280, Brazil.

Inflammation is a complex reaction involving cellular and molecular components and an unspecific response to a specific aggression. The use of scientific and technological innovations as a research tool combining multidisciplinary knowledge in informatics, biotechnology, chemistry and biology are essential for optimizing time and reducing costs in the drug design. Thus, the integration of these in silico techniques makes it possible to search for new anti-inflammatory drugs with better pharmacokinetic and toxicological profiles compared to commercially used drugs. Read More

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http://dx.doi.org/10.3390/molecules24081476DOI Listing
April 2019
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Internet of Things (IoT) Operating Systems Management: Opportunities, Challenges, and Solution.

Sensors (Basel) 2019 Apr 15;19(8). Epub 2019 Apr 15.

Department of Computer Networks, Jazan University, Jazan 45142, Saudi Arabia.

Internet of Things (IoT) is rapidly growing and contributing drastically to improve the quality of life. Immense technological innovations and growth is a key factor in IoT advancements. Readily available low cost IoT hardware is essential for continuous adaptation of IoT. Read More

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https://www.mdpi.com/1424-8220/19/8/1793
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http://dx.doi.org/10.3390/s19081793DOI Listing
April 2019
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Ultrasound in the Assessment of Tumor Response in the Age of Targeted and Immuno-Oncology Therapies. Back to the Future.

Ultraschall Med 2019 Apr 16;40(2):129-131. Epub 2019 Apr 16.

UOS Diagnostic an Ultrasound innovations, UOC Head and Neck Radiology, Policlinico Umberto I, Univ. Sapienza, Rome.

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http://dx.doi.org/10.1055/a-0834-8353DOI Listing
April 2019
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PERSPECTIVES: Mental Health Policy in India: Seven Sets of Questions and Some Answers.

J Ment Health Policy Econ 2019 Mar;22(1):25-37

Center for Analytical Finance, 421 E2 Building, University of California, Santa Cruz, CA 95064, USA,

Background: This paper frames the state of mental health policy in India in terms of seven sets of questions, and seeks to provide at least partial answers to these questions, based on a meta-analysis of existing research. The context of the analysis is the arguably poor state of mental health care in India, as well as an unprecedented level of policy attention to the issue.

Aims Of The Study: In brief, the questions we pose pertain to (i) the provision of such care in hospitals, (ii) non-hospital provision, including by non-medical providers, (iii) issues of education and social acceptance, (iv) affordability, (v) within-country variation of care and possibilities for benchmarking, (vi) aggregate resource impacts of a concerted effort to change policies and improve care, and (vii) the shape of a more effective "continuum of care" for mental health issues. Read More

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Improving Operating Room Efficiency.

Curr Urol Rep 2019 Apr 15;20(6):28. Epub 2019 Apr 15.

Division of Urology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Purpose Of Review: Operating rooms are critical financial centers for hospital systems, with surgical care representing about a third of all health care spending. However, not all of the costs are appropriate or necessary, as there are sometimes significant inefficiencies in how operating rooms are utilized.

Recent Findings: Recent innovations utilizing patient-centered data, systems principles from manufacturing industries, and enhanced communication processes have made significant improvements in improving operating room efficiency. Read More

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http://dx.doi.org/10.1007/s11934-019-0895-3DOI Listing

Retrospective Analysis of Indications and Complications Related to Implantation of Permanent Pacemaker: 25 Years of Experience in 31 Dogs.

J Vet Res 2019 Mar 22;63(1):133-140. Epub 2019 Mar 22.

Department of Internal Medicine with Clinic of Diseases of Horses, Dogs, and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-366 Wrocław, Poland.

Introduction: Pacemaker implantation is the only effective symptomatic treatment for life-threatening bradyarrhythmias. Major complications observed after implantation of cardiac pacemakers include lead dislocation, loss of pulse generator function, and inadequate stimulation. The aim of this retrospective single-centre study was to analyse the indications for pacemaker implantation and the incidence and types of complications associated with this procedure in dogs treated for symptomatic bradyarrhythmia. Read More

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http://dx.doi.org/10.2478/jvetres-2019-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458549PMC
March 2019
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Sixty years of tracking conservation progress using the World Database on Protected Areas.

Nat Ecol Evol 2019 Apr 15. Epub 2019 Apr 15.

UN Environment World Conservation Monitoring Centre (UNEP-WCMC), Cambridge, UK.

The world's protected area network is constantly changing, and the dynamics of this network are tracked using the World Database on Protected Areas (WDPA). This database evolved from a list of protected areas first mandated by the United Nations in 1959, and it now informs the key indicators that track progress toward area-based conservation targets. In this capacity, the WDPA illuminates the role of protected areas in advancing a range of international objectives and agreements, including the Convention on Biological Diversity and the Sustainable Development Goals. Read More

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http://www.nature.com/articles/s41559-019-0869-3
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http://dx.doi.org/10.1038/s41559-019-0869-3DOI Listing
April 2019
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A Secure Mutual Batch Authentication Scheme for Patient Data Privacy Preserving in WBAN.

Sensors (Basel) 2019 Apr 3;19(7). Epub 2019 Apr 3.

Department of Computer Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 611731, China.

The current advances in cloud-based services have significantly enhanced individual satisfaction in numerous modern life areas. Particularly, the recent spectacular innovations in the wireless body area networks (WBAN) domain have made e-Care services rise as a promising application field, which definitely improves the quality of the medical system. However, the forwarded data from the limited connectivity range of WBAN via a smart device (e. Read More

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http://dx.doi.org/10.3390/s19071608DOI Listing

Experimental Chemistry and Structural Stability of AlNb₃ Enabled by Antisite Defects Formation.

Materials (Basel) 2019 Apr 3;12(7). Epub 2019 Apr 3.

Department of Materials Science, Montanuniversität Leoben, Franz-Josef-Strasse 18, A-8700 Leoben, Austria.

First-principles evolutionary algorithms are employed to shed light on the phase stability of Al⁻Nb intermetallics. While the tetragonal Al₃Nb and AlNb₂ structures are correctly identified as stable, the experimentally reported Laves phase of AlNb₃ yields soft phonon modes implying its dynamical instability at 0 K. The soft phonon modes do not disappear even upon elevating the temperature in the simulation up to 1500 K. Read More

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http://dx.doi.org/10.3390/ma12071104DOI Listing

Stubbing out hypothetical bias: improving tobacco market predictions by combining stated and revealed preference data.

J Health Econ 2019 Apr 2;65:93-102. Epub 2019 Apr 2.

Choice Modelling Centre & Institute for Transport Studies, University of Leeds, United Kingdom.

In health, stated preference data from discrete choice experiments (DCEs) are commonly used to estimate discrete choice models that are then used for forecasting behavioral change, often with the goal of informing policy decisions. Data from DCEs are potentially subject to hypothetical bias. In turn, forecasts may be biased, yielding substandard evidence for policymakers. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2019.03.011DOI Listing

Digital Wings: Innovations in Transplant Readiness for Adolescent and Young Adult Transplant Recipients.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Department of Surgery, Ohio State University, Columbus, OH, USA.

The Johns Hopkins University School of Medicine organized two multi-stakeholder symposia in February 2, 2018 and January 11, 2019 to address the problem of high graft failure in adolescent and young adult (AYA) solid organ transplant (SOT) recipients. Participants included international experts in transplantation, behavioral psychology, patient/parent advocacy, and technology. The objectives of the symposia were to: i), identify and discuss the barriers to and facilitators of effective transfer of care for AYA SOT recipients; ii) actively explore strategies and digital solutions to promote their successful transfer of care; and iii) develop meaningful partnerships for the successful development, evaluation, implementation, and dissemination of these digital solutions. Read More

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http://dx.doi.org/10.1097/TP.0000000000002749DOI Listing
April 2019
1 Read