1,231 results match your criteria Inner Ear Sudden Hearing Loss


Video Head Impulse Test Findings in Patients With Benign Paroxysmal Positional Vertigo Secondary to Idiopathic Sudden Sensorineural Hearing Loss.

Front Neurol 2022 2;13:877777. Epub 2022 Jun 2.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Benign paroxysmal positional vertigo (BPPV) is amongst the most common causes of episodic vestibular syndrome. It can be classified as idiopathic and secondary types according to the causative factors, and the underlying mechanism between idiopathic (i-BPPV) and secondary BPPV (s-BPPV) may differ. Idiopathic sudden sensorineural hearing loss (ISSNHL) has been considered as a common inner ear disease that precipitates s-BPPV. Read More

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Tinnitus and Mild Hearing Loss From a Kiss.

Cureus 2022 May 12;14(5):e24955. Epub 2022 May 12.

Hospital Medicine, CHRISTUS Spohn Hospital Corpus Christi - Shoreline, Corpus Christi, USA.

Hearing loss is a common problem that everyone faces at some point in their life. There are three main types of hearing loss: conductive, sensorineural, and mixed. Conductive hearing loss occurs when an external sound is not able to gain access to the inner ear because of some type of obstruction, e. Read More

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The protective effects of systemic dexamethasone on sensory epithelial damage and hearing loss in targeted Cx26-null mice.

Cell Death Dis 2022 Jun 10;13(6):545. Epub 2022 Jun 10.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Mutations in the GJB2 gene (encoding Connexin26(Cx26)) are the most common cause of hereditary deafness, accounting for about a quarter of all cases. Sensory epithelial damage is considered to be one of the main causes of deafness caused by GJB2 gene mutation. Dexamethasone (DEX) is widely used in the treatment of a variety of inner ear diseases including sudden sensorineural hearing loss (SSNHL), noise-induced hearing loss (NIHL), and deafness caused by ototoxic drugs. Read More

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Traumatic Stapes Luxation into the Vestibule.

Ear Nose Throat J 2022 May 31:1455613221106215. Epub 2022 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, 183696Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

We report a rare case of traumatic stapes luxation into the vestibule. A 31-year-old female visited an emergency room with sudden onset of vertigo and conductive hearing loss after accidental penetrating injury to the right ear. Temporal bone computed tomography detected pneumolabyrinth, with a shade of whole intact stapes in the vestibule. Read More

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Investigational Medicinal Products for the Inner Ear: Review of Clinical Trial Characteristics in ClinicalTrials.gov.

J Am Acad Audiol 2021 11 24;32(10):670-694. Epub 2022 May 24.

Department of Speech, Language, and Hearing, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.

Background: The previous 30 years have provided information on the mechanisms of cell death in the inner ear after noise exposure, ototoxic drug injury, and during aging, and clinical trials have emerged for all of these acquired forms of hearing loss. Sudden hearing loss is less well understood, but restoration of hearing after sudden hearing loss is also a long-standing drug target, typically using steroids as an intervention but with other agents of interest as well.

Purpose: The purpose of this review was to describe the state of the science regarding clinical testing of investigational medicinal products for the inner ear with respect to treatment or prevention of acquired hearing loss. Read More

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November 2021

COVID-19 and Sudden Sensorineural Hearing Loss: A Systematic Review.

Front Neurol 2022 28;13:883749. Epub 2022 Apr 28.

Department of Otolaryngology, Wuxi Huishan District People's Hospital, Wuxi, China.

A growing body of evidence suggests that patients with the 2019 Coronavirus disease (COVID-19) have a risk of developing sudden sensorineural hearing loss (SSNHL). The pathogenesis of COVID-19-related SSNHL remains unclear. This systematic review examined whether COVID-19 causes an increased incidence of SSNHL and the clinical characteristics of patients with COVID-19-related SSNHL according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Read More

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Autoimmune thyroiditis in patients with sudden sensorineural hearing loss.

Laryngoscope Investig Otolaryngol 2022 Apr 10;7(2):571-577. Epub 2022 Feb 10.

Department of Otolaryngology Head and Neck Surgery The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou China.

Objective: This study aims to evaluate the association between autoimmune thyroiditis and Sudden Sensorineural Hearing Loss (SSNHL).

Methods: Hundred and five patients with SSNHL were enrolled. Audiometric tests, serum thyroid autoantibodies (TPOAb, TgAb) were studied. Read More

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Idiopathic Sudden Sensorineural Hearing Loss in Different Ages: Prognosis of Patients With Initial Total Hearing Loss.

Front Psychol 2022 24;13:818967. Epub 2022 Mar 24.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: This study aimed to analyze the hearing improvement and prognosis factors of idiopathic sudden sensorineural hearing loss (ISSNHL) in different ages with initial total hearing loss.

Methods: We reviewed the medical records of 5,711 hospitalized patients with ISSNHL from 2016 to 2021 in our center. All of the patients had been treated with uniform combination drug therapy. Read More

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Injected 3T-3D-FLAIR-MRI labyrinthine patterns match with the severity and tonotopic alteration in sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol 2022 Mar 14. Epub 2022 Mar 14.

Department of Radiology, CHU Gabriel Montpied, Clermont-Ferrand, France.

Purpose: The aim of the study was to assess a correlation between MRI labyrinthine changes detected with IV-gadolinium optimized high-resolution 3D-FLAIR sequences 4 h after injection (OPT4-3DFLAIR) and the type of SSNHL, in terms of frequency alteration and severity.

Methods: This was a prospective monocentric study achieved from July 2019 to December 2020. The inclusion criterion was acute hearing loss of at least 30 dB over three contiguous frequencies occurring within a 72-h period, documented by a pure-tone audiometry (PTA). Read More

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Sudden Sensorineural Hearing Loss and Why It's an Emergency.

Cureus 2022 Jan 19;14(1):e21418. Epub 2022 Jan 19.

Neurology, Centra Health System, Lynchburg, USA.

This review shows the importance of sudden sensorineural hearing loss (SSNHL) as a significant cause of hearing loss that often goes under-recognized, especially by primary care physicians. Contrasted with conductive hearing loss, SSNHL involves inner ear damage. This work reviewed the diagnostic methods and treatments of SSNHL in the U. Read More

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January 2022

[Analysis of coagulation state in sudden deafness patients with total deafness and vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;36(3):172-176

Department of Otolaryngology Head and Neck Surgery,Hebei General Hospital.

To analyze the coagulation status and prognosis of sudden deafness patients with total deafness accompanied by vertigo, and to provide basis for improving the treatment of this disease. From January 2017 to December 2020, 33 patients with total deafness and vertigo sudden deafness who were hospitalized in the Department of Otolaryngology Head and Neck Surgery, Hebei Provincial People's Hospital were selected as the research group. During the same period, 33 cases of low frequency type, full frequency type, total deafness and 26 cases of high frequency type were treated as control group. Read More

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Single-Cell Analysis of Steroid-Responsive Gene Targets in the Mammalian Cochlea.

Front Neurol 2021 25;12:818157. Epub 2022 Jan 25.

Department of Otolaryngology-Head and Neck Surgery, Georgetown University School of Medicine, Washington, DC, United States.

Background: Treatment of many types of hearing instability in humans, including sudden sensorineural hearing loss, Meniere's disease, and autoimmune inner ear disease, rely heavily on the utilization of corticosteroids delivered both by oral and transtympanic routes. Despite this use, there is heterogeneity in the response to treatment with corticosteroids in humans with these diseases. The mechanisms by which corticosteroids exert their effect and the cell types in which they exert their effects in the inner ear remain poorly characterized. Read More

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January 2022

Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss-A Retrospective Study.

Life (Basel) 2022 Jan 10;12(1). Epub 2022 Jan 10.

Institute of Sensory Organs, Nadarzyn, 05830 Warsaw, Poland.

(1) Background: A retrospective clinical study was conducted to compare the effectiveness of different pharmacological and non-pharmacological regimens for treating sudden sensorineural hearing loss (SSNHL). (2) Methods: Adult patients ( = 130) diagnosed with sudden sensorineural hearing loss (SSNHL) and hospitalized between 2015 and 2020 were enrolled in this study. Depending on the treatment regimen applied, patients were divided into five groups. Read More

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January 2022

Association of αENaC p. Ala663Thr Gene Polymorphism With Sudden Sensorineural Hearing Loss.

Front Genet 2021 22;12:659517. Epub 2021 Dec 22.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The etiology of sudden sensorineural hearing loss (SSNHL) is still unknown. It has been demonstrated that normal endolymph metabolism is essential for inner ear function and that epithelial sodium channels (ENaC) may play an important role in the regulation of endolymphatic Na. This study aimed to explore the potential association between αENaC p. Read More

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December 2021

Round window membrane rupture following blunt force trauma.

Ann R Coll Surg Engl 2022 Jan;104(1):e12-e13

The Ear Centre, Green Pastures Hospital, Nepal.

Round window rupture following barotrauma such as diving and air travel is well documented. However, we describe a case of round window rupture following a slap to the ear, which has not been described previously. A 12-year-old boy was slapped by his teacher in rural Nepal over his left ear and immediately noted hearing loss. Read More

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January 2022

Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness.

Am J Otolaryngol 2022 Mar-Apr;43(2):103331. Epub 2021 Dec 16.

Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University and Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Purpose: Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects.

Methods: Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests were included. Read More

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Clinical Value of 3D-FLAIR MRI in Idiopathic Sudden Sensorineural Hearing Loss.

ACS Chem Neurosci 2022 01 17;13(1):151-157. Epub 2021 Dec 17.

Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, 4# Duanxing West Road, Jinan 250022, China.

Background: Three-dimensional fluid-attenuated inversion recovery sequence magnetic resonance imaging (3D-FLAIR MRI) has been used in the diagnosis of inner ear diseases. However, the relevance of 3D-FLAIR MRI appearances with multiple features and prognosis of patients with idiopathic sudden sensorineural hearing loss (ISSNHL) remains unclear.

Methods: This study was a retrospective trial. Read More

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January 2022

Staged surgical management of idiopathic sudden sensorineural hearing loss refractory to medical treatment

Orv Hetil 2021 12 19;162(51):2055-2060. Epub 2021 Dec 19.

1 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ, Fül- Orr-Gégészeti és Fej-Nyaksebészeti Klinika Pécs, Munkácsy M. u. 2., 7621.

Összefoglaló. A hirtelen halláscsökkenés patofiziológiája még nagyrészt tisztázatlan, így oki terápia nem lehetséges. Az elsődleges kezelést a helyileg vagy szisztémásan adott kortikoszteroid jelenti, egységes protokoll azonban nem áll rendelkezésre. Read More

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December 2021

Hearing improvement after vestibular schwannoma surgery in the era of the hearing preservation rule - case report and literature review.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Dec 9. Epub 2021 Dec 9.

Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, V Uvalu 84, 150 06, Prague 5, Czech Republic.

Objectives: Hearing preservation after vestibular schwannoma (VS) surgery remains a surgical challenge. In some patients with preserved inner ear function, hearing improvement is achievable. As it is currently impossible to determine which patients will present this outcome, predictions must rely on previously published reports. Read More

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December 2021

Vestibular and auditory manifestations of migraine.

Curr Opin Neurol 2022 02;35(1):84-89

University of California, San Francisco (UCSF) Department of Otolaryngology - Head and Neck Surgery, San Francisco.

Purpose Of Review: The purpose of this narrative review is to discuss current literature about vestibular migraine and other cochleovestibular symptoms related to migraine.

Recent Findings: Vestibular migraine affects 2.7% of the US population. Read More

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February 2022

Triamcinolone acetonide can be detected in cerebrospinal fluid after intratympanic injection.

Eur J Pharm Biopharm 2022 Jan 2;170:52-58. Epub 2021 Dec 2.

Medical University of Vienna, Vienna, Austria, Department of Otorhinolaryngology, Head and Neck Surgery, Austria. Electronic address:

Intratympanically applied treatments are of increasing interest to the otologic community to treat sudden sensorineural hearing loss or vestibular disorders but also to deliver gene therapy agents, or biologics to the inner ear. Further diversion from the middle ear and perilymph to blood circulation and cerebrospinal fluid via the cochlear aqueduct are one of the limiting factors and so far not understood well enough. In this study, intratympanically applied triamcinolone acetonide was determined in cerebrospinal fluid. Read More

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January 2022

Intracochlear Hemorrhage: A Rare Cause of Sudden Sensorineural Hearing Loss.

Case Rep Radiol 2021 22;2021:1072047. Epub 2021 Nov 22.

Department of Radiology, Charles Nicolle University Hospital, Tunis, Tunisia.

Inner ear hemorrhage is an extremely rare cause of sudden sensorineural hearing loss with few cases reported in the literature. We report the case of a 30-year-old male who presented with a sudden left ear hearing loss, with no tinnitus nor vertigo. The audiogram revealed a profound left sensorineural hearing loss. Read More

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November 2021

Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis.

PLoS One 2021 29;16(11):e0260443. Epub 2021 Nov 29.

Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.

Although sensorineural hearing loss (SHL) is relatively common, its cause has not been identified in most cases. Previous studies have suggested that viral infection is a major cause of SHL, especially sudden SHL, but the system that protects against pathogens in the inner ear, which is isolated by the blood-labyrinthine barrier, remains poorly understood. We recently showed that, as audiosensory receptor cells, cochlear hair cells (HCs) are protected by surrounding accessory supporting cells (SCs) and greater epithelial ridge (GER or Kölliker's organ) cells (GERCs) against viral infections. Read More

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January 2022

Vestibular function of pediatric patients with sudden sensorineural hearing loss: based on vertigo symptom and vestibular function testing.

World J Pediatr 2021 Dec 12;17(6):637-642. Epub 2021 Nov 12.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: This study aimed to evaluate the relationship between vestibular and auditory functions in pediatric patients with sudden sensorineural hearing loss (SSHL).

Methods: A total of 30 pediatric patients experiencing unilateral SSHL between 5.9 and 13. Read More

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December 2021

Bilateral sudden sensorineural hearing loss in patient with Behçet disease.

Ear Nose Throat J 2021 Oct 18:1455613211051660. Epub 2021 Oct 18.

Department of Otolaryngology-Head and Neck Surgery, 63452Tri-Service General Hospital, Taipei, Taiwan.

Approximately 80% to 85% of sudden sensorineural hearing loss (SSNHL) is idiopathic, but immune-mediated mechanisms are thought to be involved. Behçet disease is an autoinflammatory vasculitis that may involve vessels of the inner ear. It can cause sensorineural hearing loss (SNHL) and an increased risk of SSNHL. Read More

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October 2021

Rapidly progressive hearing loss occurring over weeks: review of differential diagnoses.

J Laryngol Otol 2021 Oct 13:1-8. Epub 2021 Oct 13.

Department of Otolaryngology - Head and Neck Surgery, Sunderland Royal Hospital, Sunderland, UK.

Background: Sudden hearing loss, or progressive hearing loss occurring over months to years, are well-established presentations. However, little is described in the medical literature on how to approach patients presenting with a rapidly progressive hearing loss occurring over weeks. This study aimed to evaluate the clinical significance of patients presenting with rapidly progressive hearing loss. Read More

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October 2021

Sudden hearing loss and vestibular disorders during and before COVID-19 pandemic: An audiology tertiary referral centre experience.

Am J Otolaryngol 2022 Jan-Feb;43(1):103241. Epub 2021 Sep 16.

Department of Neuroscience DNS, Audiology Unit at Treviso Hospital, University of Padova, Treviso, Italy.

Purpose: During the Coronavirus disease 2019 (COVID-19) pandemic a reduction in the diagnosis of many otorhinolaryngological and audiological disorders has been widely reported. The main aim of this investigation was to evaluate the impact of COVID-19 outbreak on the incidence of acute hearing and vestibular disorders.

Materials And Methods: A retrospective analysis was performed of all patients evaluated in an audiology tertiary referral centre for acute cochleo-vestibular impairment between March 1st 2020 and February 28th 2021 (Pandemic Year Period, PYP). Read More

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December 2021

Audiological Patterns in Patients with Autoimmune Hearing Loss.

Audiol Neurootol 2021 Sep 10:1-10. Epub 2021 Sep 10.

1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.

Introduction: The aim of this study was to illustrate clinical and audiological patterns of hearing impairment in patients with autoimmune hearing loss (AIHL).

Methods: Fifty-three patients with AIHL were retrospectively recruited, and a tapering schema of steroid treatment was administered in all these patients. The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden (sensorineural hearing loss [SSHL]), fluctuating, or quickly progressing (<12 months) SSHL (uni-/bilateral), in association with the coexistence of autoimmune diseases, high antinuclear antibodies (ANA) and the presence of human leukocyte antigen (HLA) B27, B35, B51, C04, and C07. Read More

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September 2021

Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea.

Otol Neurotol 2021 12;42(10):e1410-e1421

Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, District of Columbia.

Objective: To identify genes implicated in sudden sensorineural hearing loss (SSNHL) and localize their expression in the cochlea to further explore potential pathogenic mechanisms and therapeutic targets.

Study Design: Systematic literature review and bioinformatics analysis.

Data Sources: The following sources were searched from inception through July 2, 2020: PubMed-NCBI, MEDLINE, Embase, CINAHL, Cochrane Library, ClinicalTrials. Read More

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December 2021

Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration.

Front Neurol 2021 19;12:641593. Epub 2021 Aug 19.

Department of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Although combination of oral and transtympanic drug therapy (CT) has been proved more effective and safer for idiopathic sudden sensorineural hearing loss (ISSNHL) by some clinical trials, there are few laboratory researches on the pharmacokinetics in the inner ear following CT on account of structural limitations of the inner ear. The aim of the present study was to investigate the pharmacokinetic behaviors of CT in the inner ear of mice. Eighteen transgenic mice which express luciferase in cochlear spiral ganglion cells were divided into oral administration (OR) group, transtympanic injection route (TT) group and CT group, and luciferin was delivered into the inner ear of these mice through oral, transtympanic or combined routes, respectively. Read More

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