1,122 results match your criteria Inner Ear Sudden Hearing Loss


Cochlear Implantation as a Treatment for Sudden Autoimmune Sensorineural Hearing Loss in a Patient Affected by Eosinophilic Granulomatosis with Polyangiitis: A Case Report and A Review of Literature.

Ann Otol Rhinol Laryngol 2020 Jul 2:3489420938827. Epub 2020 Jul 2.

Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

Objective: To report presentation, diagnostic process, management and outcome of a case of autoimmune inner ear disease (AIED) related with Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), treated with cochlear implantation, and review of relevant literature.

Case Presentation And Management: A retrospective case report of AIED associated with EGPA treated with cochlear implantation was described. A multi-step approach for diagnosis and confirmation of AIED and hearing rehabilitation was conducted, eventually leading to left cochlear implantation. Read More

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http://dx.doi.org/10.1177/0003489420938827DOI Listing

Sphenoid sinus mucocele as an unusual differential diagnosis in diving injuries.

Diving Hyperb Med 2020 Jun;50(2):168-172

Underwater and Hyperbaric Medicine Department, Istanbul Faculty of Medicine, Istanbul, Turkey.

Sphenoid sinus mucocele is a rare cystic lesion. It grows gradually and causes visual disturbances, ocular motility abnormalities and headache due to cavernous sinus compression. Sudden change in sinus cavity volume by a barotrauma may compress a mucocele and precipitate symptoms that may easily be confused with decompression sickness. Read More

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http://dx.doi.org/10.28920/dhm50.2.168-172DOI Listing

Pediatric sudden sensorineural hearing loss: Experience in a pediatric ENT emergency care center.

Int J Pediatr Otorhinolaryngol 2020 Apr 24;135:110067. Epub 2020 Apr 24.

ENT Department, Hôpital Necker-Enfants Malades, AP-HP, 149 Rue de Sèvres, 75015, Paris, France; Université de Paris, Paris, France.

Objectives: Sudden sensorineural hearing loss (SSNHL) is relatively rare and its physiopathology remains unclear, particularly in children. Our goal was to evaluate clinical characteristics, etiologies, management, treatment outcomes and prognostic factors in the pediatric population.

Methods: We performed a retrospective chart review of all children registered for SSNHL between August 2004 and September 2017 in a tertiary care pediatric hospital. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110067DOI Listing

Silk-coated dexamethasone non-spherical microcrystals for local drug delivery to inner ear.

Eur J Pharm Sci 2020 Jul 29;150:105336. Epub 2020 Apr 29.

Tianjin First Center Hospital, Tianjin 300192, China. Electronic address:

The local drug delivery systems play an important role in treating sudden sensorineural hearing loss. In this work, we synthesized dexamethasone microcrystals (DEX MCs) using precipitation technique followed by silk coating via layer-by-layer assembly. Compared to raw DEX, the physicochemical properties including shape, crystal form, dispersity, dissolution or sustained release, of DEX MCs or poly-l-lysine/silk fibroin (PLL/SF) multilayers-coated DEX MCs (DEX-(PLL/SF)) were investigated. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105336DOI Listing

A Case of Perilymphatic Fistula with Inner Ear Anomaly Diagnosed Preoperatively by the Cochlin-Tomoprotein Detection Test.

Case Rep Otolaryngol 2020 9;2020:9476915. Epub 2020 Mar 9.

Department of Otolaryngology, Saitama Medical University, Saitama, Japan.

We present a case of perilymphatic fistula (PLF) with inner ear anomalies having sudden, progressive sensorineural hearing loss and describe the fistula repair surgeries. We focus on the diagnosis methods of PLF and clinical course of PLF with inner ear anomaly. The cochlin-tomoprotein (CTP) detection test is very useful for the surgeons to encourage the earlier operation to sudden hearing loss cases. Read More

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http://dx.doi.org/10.1155/2020/9476915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085362PMC

Investigating Facial Nerve Stimulation After Cochlear Implantation in Adult and Pediatric Recipients.

Laryngoscope 2020 Mar 28. Epub 2020 Mar 28.

King Abdullah Ear Specialist Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Objectives/hypothesis: Facial nerve stimulation (FNS) can occur after cochlear implantation for a small number of recipients. This study aimed to investigate if a correlation exists between the variables involved in FNS.

Study Design: Retrospective cohort review. Read More

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http://dx.doi.org/10.1002/lary.28632DOI Listing

Intratympanic application of triamcinolone in sudden hearing loss-radiologic anatomy in cone beam CT and its' correlation to clinical outcome.

Eur Arch Otorhinolaryngol 2020 Jul 23;277(7):1931-1937. Epub 2020 Mar 23.

Department of Otorhinolaryngology, Hannover Medical University, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To evaluate temporal bone cone-beam CT in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) being treated with primary and secondary intratympanic (IT) triamcinolone and to possibly correlate these results to the clinical outcome.

Methods: Retrospective analysis of patients treated with IT triamcinolone for ISSNHL at our department in 2018. Pre- and post-therapeutic audiologic examinations included four-tone average (FTA) at 0. Read More

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http://dx.doi.org/10.1007/s00405-020-05920-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286852PMC

Steroid Nomenclature in Inner Ear Therapy.

Otol Neurotol 2020 Jul;41(6):722-726

Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

: Local glucocorticosteroid ("steroid") therapy is widely used to treat the inner ears of patients with Menière's disease, idiopathic sudden sensorineural hearing loss and in combination with cochlear implants. Applied steroids have included dexamethasone, methylprednisolone, and triamcinolone. In reality, however, this is often not true and the steroid forms commonly applied are dexamethasone-phosphate, methylprednisolone-hemisuccinate, or triamcinolone-acetonide. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002624DOI Listing

Clinical efficacy of hyperbaric oxygen therapy on idiopathic sudden sensorineural hearing loss.

Undersea Hyperb Med 2020 First Quarter;47(1):51-56

Department of Underwater and Hyperbaric Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, Yildirim, Bursa, Turkey.

Idiopathic sudden sensorineural hearing loss (ISSHL) is defined as unexplained hearing loss of at least 30 decibels (dB) occurring within 72 hours over at least three contiguous frequencies. ISSHL is common and has a significant effect on quality of life. Hyperbaric oxygen (HBO2) therapy is a medical treatment method that aims to increase the level of dissolved oxygen in the tissues. Read More

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Clinical and radiological characteristics of patients with collapse or fistula of the saccule as evaluated by inner ear MRI.

Acta Otolaryngol 2020 Apr 21;140(4):262-269. Epub 2020 Jan 21.

Department of Head and Neck Surgery, Lariboisière University Hospital, Paris, France.

Delayed 3D-FLAIR sequences enable the distinction between the utricle and the saccule. We sought to evaluate the clinical and radiological findings in patients with no visible saccule (NVS) on 4-hour post-contrast MRI. We retrospectively assessed the presence of NVS signs in 400 patients who underwent delayed inner ear MRI. Read More

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http://dx.doi.org/10.1080/00016489.2020.1713396DOI Listing

Inner ear disorders.

Cas Lek Cesk 2019 ;158(6):216-220

Auditory part of the inner ear transforms mechanic energy to the electric energy. The key component of this process are hair cells, which damage leads to often irreversible hearing impairment. The damage can occur due to several external and internal causes and the treatment focuses mainly onto the mitigation of the consequences. Read More

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January 2020

Review of the pathology underlying benign paroxysmal positional vertigo.

Authors:
Sertac Yetiser

J Int Med Res 2019 Dec 29:300060519892370. Epub 2019 Dec 29.

Department of Otolaryngology-Head and Neck Surgery, Anadolu Medical Center, Gebze, Kocaeli, Turkey.

The pathophysiological mechanism underlying benign paroxysmal positional vertigo (BPPV) is related to free-floating debris/otoliths in the semicircular canal (canalolithiasis) or debris/otoliths attached to the cupula (cupulolithiasis). These debris/otoliths are considered to originally accumulate after detachment from the neuroepithelium of the utricular macula secondary to a type of degeneration. An idiopathic form, which is assumed to occur spontaneously, is diagnosed when the causative pathology is obscure. Read More

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http://dx.doi.org/10.1177/0300060519892370DOI Listing
December 2019

The Role of Endolymphatic Hydrops in Patients with Pantonal Idiopathic Sudden Sensorineural Hearing Loss: A Cause or Secondary Reaction.

Curr Med Sci 2019 Dec 16;39(6):972-977. Epub 2019 Dec 16.

Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and technology, Wuhan, 430030, China.

The purpose of this study was to investigate the presence of endolymphatic hydrops (EH) in both affected and unaffected ears of patients with pantonal unilateral idiopathic sudden sensorineural hearing loss (ISSNHL) using three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) and further evaluate the significance of EH in this disorder. Twenty-seven ISSHL patients were enrolled in this study. 3D-FLAIR MRI was performed 24 h after intratympanic injection of gadolinium-diethylenetriaminepentaacetic acid (Gd-DPTA). Read More

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http://dx.doi.org/10.1007/s11596-019-2130-3DOI Listing
December 2019

Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.

Authors:
Yi-Ho Young

Int J Audiol 2020 Apr 12;59(4):243-253. Epub 2019 Nov 12.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

This article provides an overview of the causes and differential diagnosis of sudden deafness (SD) and sudden sensorineural hearing loss (SSHL). Contemporary review. This review is based on peer-reviewed articles published in those journals listed on journal of citation reports. Read More

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http://dx.doi.org/10.1080/14992027.2019.1689432DOI Listing

Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing.

Theranostics 2019 23;9(24):7184-7199. Epub 2019 Sep 23.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.

: Mutations of that abrogate pendrin, expressed in endolymphatic sac, cochlea and vestibule, are known to cause autosomal recessive sensorineural hearing loss with enlargement of the membranous labyrinth. This is the first study to demonstrate the feasibility of gene therapy for pendrin-related hearing loss. We used a recombinant viral vector to transfect cDNA into embryonic day 12. Read More

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http://dx.doi.org/10.7150/thno.38032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831294PMC
September 2019

Hearing loss after radiosurgery-blame it on Cochlear dose or the radiation tool!

Radiat Oncol 2019 Oct 30;14(1):186. Epub 2019 Oct 30.

Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

While sudden hearing loss after stereotactic radiosurgery has been demonstrated in some cases a recent article by Linge et al. and have demonstrated the need for further discussion on this topic. We attempt to delineate the fact that the type of dosing regimen or technology used will not affect the hearing or radio-graphical control outcomes and thus should not be a consideration while administering treatment. Read More

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http://dx.doi.org/10.1186/s13014-019-1390-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822357PMC
October 2019
2.546 Impact Factor

Pediatric Autoimmune Inner Ear Disease: A Rare, But Treatable Condition.

Pediatr Ann 2019 Oct;48(10):e391-e394

Autoimmune inner ear disease (AIED) is a rare, but treatable cause of sudden sensorineural hearing loss in children. Most cases present acutely and involve both ears. The precise mechanism of hearing loss in AIED is not known. Read More

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http://dx.doi.org/10.3928/19382359-20190923-01DOI Listing
October 2019
2 Reads

Optimal Head Position Following Intratympanic Injections of Steroids, As Determined by Virtual Reality.

Otolaryngol Head Neck Surg 2019 12 24;161(6):1012-1017. Epub 2019 Sep 24.

Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: To study optimal head position after intratympanic steroid injections to enhance drug bioavailability.

Study Design: Application of virtual and in vitro models of the intratympanic anatomy.

Setting: The surgical 3-dimensional printing laboratory of a tertiary academic medical center. Read More

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http://dx.doi.org/10.1177/0194599819878699DOI Listing
December 2019

[Vestibular function test in patients sudden sensorineural hearing loss patients with vertigoand its clinical significance].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Aug;33(8):749-752

College of Medical Technology,Zhejiang Chinese Medical University,Hangzhou,310053,China.

The aim of this study is to analyze the results of vestibular function tests and clinical value of patients with sudden sensorineural hearing loss (SSHL) and vertigo. Twelve cases(24 ears) of unilateral SSHL with vertigo were included in the study group. 11 age and sex matched normal subjects(22 ears) were recruited as the normal control group. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.08.016DOI Listing

[Clinical characteristics and etiological analysis of sudden deafness patients with vertigo].

Zhonghua Yi Xue Za Zhi 2019 Jul;99(28):2197-2202

Department of Otolaryngology, First Affiliated Hospital of Sun Yat-sen University, Institute of Otolaryngology, Sun Yat-sen University, Guangzhou 510080, China.

To explore the possible causes and mechanisms of sudden deafness with vertigo. Between August 2016 and December 2017, 74 patients with sudden deafness and vertigo were hospitalized in the Department of Otolaryngology, First Affiliated Hospital of Sun Yat-sen University. Among them, 36 were male and 38 were female, aged 18-75 (40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.28.009DOI Listing
July 2019
4 Reads

Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear.

Front Cell Neurosci 2019 30;13:347. Epub 2019 Jul 30.

Otonomy Inc., San Diego, CA, United States.

Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each delivered as crystalline suspensions to guinea pigs. Triamcinolone-acetonide is a widely used form of the drug with molecular properties that allow it to readily permeate biological barriers. Read More

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http://dx.doi.org/10.3389/fncel.2019.00347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689996PMC

Magnetic resonance imaging findings in idiopathic sudden sensorineural hearing loss.

Acta Radiol 2019 Sep 8;60(9):1167-1174. Epub 2019 Jan 8.

2 Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1177/0284185118820053DOI Listing
September 2019
2 Reads

MicroRNAs in acquired sensorineural hearing loss.

J Laryngol Otol 2019 Aug 30;133(8):650-657. Epub 2019 Jul 30.

Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, Canada.

Objective: This review summarises the current literature on the role of microRNAs in presbyacusis (age-related hearing loss) and sudden sensorineural hearing loss.

Methods: Medline, PubMed, Web of Science and Embase databases were searched for primary English-language studies, published between 2000 and 2017, which investigated the role of microRNAs in the pathogenesis of presbyacusis or sudden sensorineural hearing loss. Quality of evidence was assessed using the National Institutes of Health quality assessment tool. Read More

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http://dx.doi.org/10.1017/S0022215119001439DOI Listing

[Clinical study of inner ear hemorrhage-associated sudden deafness and vertigo].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jul;54(7):495-500

Department of Otorhinolaryngology, the First Affiliated Hospital, Sun Yat-sen University and Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou 510080, China.

To analyze the clinical features and possible pathogenesis of sudden deafenss and vertigo induced by inner ear hemorrhage. Clinical data of 30 patients with inner ear hemorrhage, from the first affiliated hospital of Sun Yat-sen university during Jan 2016 to May 2017, were retrospectively analyzed. Vergito and profound deafness were seen in all patients. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.07.003DOI Listing
July 2019
4 Reads

Poly-Lactic Acid-Based Biopolymer Formulations Are Safe for Sustained Intratympanic Dexamethasone Delivery.

Otol Neurotol 2019 08;40(7):e739-e746

Department of Clinical Neurosciences, Service of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Geneva (HUG).

Hypothesis And Background: The clinical treatment of sudden sensorineural hearing loss currently relies on the administration of steroids, either systemically or via intratympanic injections. Intratympanic injections bypass the hemato-cochlear barrier, reducing its systemic side effects. The efficacy of the injections is limited through rapid drug clearance via the Eustachian tube, and through nonoptimal properties of slow-release drug carriers. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002305DOI Listing
August 2019
2 Reads

Comparison of inner ear drug availability of combined treatment with systemic or local drug injections alone.

Neurosci Res 2020 Jun 3;155:27-33. Epub 2019 Jul 3.

Department of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Combination of systemic and local drug therapy has been proved more effective and safer for idiopathic sudden sensorineural hearing loss by some clinical trials, and there are few laboratory researches on its pharmacokinetic behaviors in the inner ear. In the present study, we use a new in vivo imaging system to compare the pharmacokinetics of combined therapy (CT), with intravenous (IV) or transtympanic (TT) injection alone in both ears of transgenic GFAP-Luc mice. Biological half-life, total photon counts and the area under the curve (AUC) value significantly increased after CT. Read More

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http://dx.doi.org/10.1016/j.neures.2019.07.001DOI Listing
June 2020
1 Read
1.937 Impact Factor

Abnormal Tectorial Membranes in Sensorineural Hearing Loss: A Human Temporal Bone Study.

Otol Neurotol 2019 08;40(7):e732-e738

Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

Hypothesis: This study evaluates the morphological changes of the tectorial membrane (TM) in conjunction with degeneration of hair cells, interdental cells, and presence of endolymphatic hydrops (EH) in sensorineural hearing loss (HL) in the human using histopathology techniques.

Background: The TM plays an important role in mechanical transduction of acoustic energy, and pathology of the TM may result in HL.

Methods: All temporal bone (TB) specimens from the Massachusetts Eye and Ear Otopathology Laboratory from patients with various causes of sensorineural HL and morphological abnormalities of the TM were evaluated. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002286DOI Listing
August 2019
10 Reads

Rosiglitazone Improves Glucocorticoid Resistance in a Sudden Sensorineural Hearing Loss by Promoting MAP Kinase Phosphatase-1 Expression.

Mediators Inflamm 2019 14;2019:7915730. Epub 2019 May 14.

Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Xuhui District, 200233 Shanghai, China.

In this study, we investigated the role of MAP kinase phosphatase-1 (MKP-1) and rosiglitazone (RSG) in glucocorticoid resistance and glucocorticoid sensitivity, respectively, using a guinea pig model of lipopolysaccharide- (LPS-) induced sudden sensorineural hearing loss (SSHL). The pigs were divided into control, LPS, LPS+dexamethasone (DEX), LPS+RSG, and LPS+DEX+RSG groups. Their hearing was screened by auditory brainstem response measurement. Read More

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http://dx.doi.org/10.1155/2019/7915730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537012PMC
January 2020
5 Reads

A sudden bilateral hearing loss caused by inner ear hemorrhage.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Jan 6;137(1):65-67. Epub 2019 Jun 6.

Department of otorhinolaryngology, head and neck surgery, university hospital Center, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France.

Introduction: Labyrinthine hemorrhage is a rare cause of sudden deafness and generally concerns only on one side.

Case Summary: An 84-year-old man with a past medical history of myelomonocytic chronic leukemia (CMML) suffered from sudden bilateral hearing loss associated with vertigo. The audiogram revealed a left cophosis and a right profound deafness. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.05.021DOI Listing
January 2020
3 Reads

Predicting cochlear dead regions in patients with hearing loss through a machine learning-based approach: A preliminary study.

PLoS One 2019 3;14(6):e0217790. Epub 2019 Jun 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

We propose a machine learning (ML)-based model for predicting cochlear dead regions (DRs) in patients with hearing loss of various etiologies. Five hundred and fifty-five ears from 380 patients (3,770 test samples) diagnosed with sensorineural hearing loss (SNHL) were analyzed. A threshold-equalizing noise (TEN) test was applied to detect the presence of DRs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217790PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546232PMC
February 2020
13 Reads

Magnetic resonance imaging of the endolymphatic space in patients with acute low-tone sensorineural hearing loss.

Auris Nasus Larynx 2019 Dec 7;46(6):859-865. Epub 2019 May 7.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan.

Objective: The aim of this study was to measure the volume of the endolymphatic space (ELS) and to investigate prognosis in patients with acute low-tone sensorineural hearing loss (ALHL).

Methods: A total of 61 ALHL patients participated; 47 were definite while 14 were probable ALHL cases. The definite ALHL patients were classified into three groups: A, "Cure"; B, "No cure"; and C, "Recurrence. Read More

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http://dx.doi.org/10.1016/j.anl.2019.04.003DOI Listing
December 2019
8 Reads

Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases.

Int J Neurosci 2019 Oct 9;129(10):1004-1012. Epub 2019 May 9.

Department of Otorhinolaryngology - Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine , Xi'an , People's Republic of China.

This study aimed to assess the clinical value of ocular vestibular evoked myogenic potential (oVEMP) and cervical vestibular evoked myogenic potential (cVEMP) for monitoring the rehabilitation of vestibular function in patients treated for peripheral vertigo. Fifteen patients who had been diagnosed with peripheral vertigo and showed no VEMP response on the affected side but exhibited symptom alleviation and VEMP responses after therapies were retrospectively enrolled. We analyzed the restoration and parameters of their VEMP response. Read More

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http://dx.doi.org/10.1080/00207454.2019.1608201DOI Listing
October 2019
8 Reads
1.528 Impact Factor

Use of Gases to Treat Cochlear Conditions.

Authors:
Jay C Buckey

Front Cell Neurosci 2019 24;13:155. Epub 2019 Apr 24.

Space Medicine Innovations Laboratory, Center for Hyperbaric Medicine, Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.

Although the cochlear vascular supply (stria vascularis) is designed to block to certain compounds and molecules, it must enable gas exchange to survive. The inner ear capillaries must deliver oxygen and remove carbon dioxide for the cochlea to function. These gases diffuse through tissues across a concentration gradient to reach the desired target. Read More

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http://dx.doi.org/10.3389/fncel.2019.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491859PMC
April 2019
2 Reads

Different prognoses in patients with profound sudden sensorineural hearing loss.

Acta Otolaryngol 2019 Jul 3;139(7):598-603. Epub 2019 May 3.

a Department of Otorhinolaryngology Head and Neck Surgery , the First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Inner ear hemorrhage is increasingly recognized as a cochlear lesion that can cause profound sudden sensorineural hearing loss (SSNHL). To investigate changes of cochlear and vestibular function and to compare therapeutic recovery from profound SSNHL induced by different etiologies. Eighty patients with profound SSNHL (≥90 dB) were divided into an inner ear hemorrhage group and a non-inner ear hemorrhage group by MRI. Read More

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http://dx.doi.org/10.1080/00016489.2019.1605195DOI Listing
July 2019
8 Reads

[Analysis of prognostic factors influencing the effectiveness of treatment in sudden sensorineural hearing loss].

Orv Hetil 2019 May;160(18):687-693

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Munkácsy M. utca 2., 7621.

Sudden sensorineural hearing loss is defined as a greater than 30 dB deterioration in at least 3 consecutive frequencies occurring within 72 hours. The disease is mostly idiopathic and needs an urgent treatment. Between 01. Read More

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http://dx.doi.org/10.1556/650.2019.31368DOI Listing
May 2019
6 Reads

Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1312-1320

a Department of Otolaryngology, Hearing Research Laboratory , University of Miami Miller School of Medicine , Miami , FL, USA.

Hearing loss is the most common neurosensory impairment worldwide. While conductive hearing loss can be managed by surgery, the management of sensorineural hearing loss (SNHL), related to the damage of sensory cells of the inner ear is more challenging to manage medically. Many causes of SNHL such as sudden idiopathic SNHL, Meniere's disease, noise-induced hearing loss, autoimmune hearing loss or hearing loss from exposure to ototoxic substances can benefit from delivery of otoprotective drugs to the inner ear. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573182DOI Listing
December 2019
10 Reads

Cochlear Capillary Pericytes.

Adv Exp Med Biol 2019 ;1122:115-123

The Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Munich, Germany.

Capillary pericytes in the cochlea of mammals are-compared to pericytes in other tissues, like the CNS-relatively poorly researched. To begin with, there is still a considerable debate as to whether the very last precapillary arterioles should-due to their contractile properties-may be considered to be pericytes.However, cochlear capillary pericytes have shifted into the center of attention in the past decade. Read More

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http://dx.doi.org/10.1007/978-3-030-11093-2_7DOI Listing
August 2019
1 Read

The Natural History of Labyrinthine Hemorrhage in Patients With Sudden Sensorineural Hearing Loss.

Ear Nose Throat J 2019 Jun 26;98(5):E13-E20. Epub 2019 Mar 26.

1 Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China.

To investigate the application of inner ear 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) in patients with sudden sensorineural hearing loss (SSNHL) accompanied by inner ear hemorrhage. A total of 1252 SSNHL patients who were admitted from January 2010 to April 2018 were included in the study. The patients' clinical features, complete blood counts, coagulation profiles, audiometry data, and MRI scans were retrospectively reviewed. Read More

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http://journals.sagepub.com/doi/10.1177/0145561319834862
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http://dx.doi.org/10.1177/0145561319834862DOI Listing
June 2019
6 Reads

Perilymphatic fistula and pneumolabyrinth without temporal bone fracture: a rare entity.

BMJ Case Rep 2019 Mar 1;12(3). Epub 2019 Mar 1.

Otorhinolaryngology - Head & Neck Surgery, Hospital de Braga, Braga, Portugal.

Post-traumatic pneumolabyrinth is an uncommon clinical entity, particularly in the absence of temporal bone fracture. We report the case of a patient who presented to our emergency department with a headache, sudden left hearing loss and severe dizziness which began after a traumatic brain injury 3 days earlier. On examination, the patient presented signs of left vestibulopathy, left sensorineural hearing loss and positive fistula test, normal otoscopy and without focal neurological signs. Read More

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http://dx.doi.org/10.1136/bcr-2018-228457DOI Listing
March 2019
8 Reads

[Analysis of clinical features of secondary benign paroxysmal positional vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Mar;33(3):220-224

Center of Vertigo Clinic Research of Aerospace, General Hospital of PLA Air Force, Beijing, 100142, China.

To analyze the clinical features of secondary benign paroxysmal positional vertigo (BPPV) and provide evidence for its precise diagnosis and treatment. There were 942 patients with vertigo related to BPPV, including 204 patients with primary BPPV, 592 patients with vestibular migraine (VM), 83 patients with Meniere's disease (MD), 48 patients with vestibular neuronitis (VN), and 15 patients with sudden sensorineural hearing loss (SSNHL) accompanied by vertigo.There were 127 patients with BPPV secondary to vertigo in MD, VN, VM, and SSNHL. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.03.009DOI Listing
March 2019
8 Reads

Intratympanic steroid therapy for refractory sudden sensory hearing loss: a 12-year experience with the Silverstein catheter.

Acta Otolaryngol 2019 Feb 22;139(2):111-116. Epub 2019 Feb 22.

a Department of Otorhinolaryngology , CHU Liege , Liège , Belgium.

Background: Sudden sensorineural hearing loss (SSNHL) is commonly encountered in clinical practice.

Aim/objective: Determine if local administration of corticosteroids to the inner ear can improve hearing and speech intelligibility after the failure of conventional treatment for SSNHL loss when administered for 10 days after the onset of the hearing loss in a large cohort of 77 patients.

Materials And Methods: A Silverstein MicroWick™ was placed under local anesthesia and endoscopic control in the round window niche, allowing self-administration of methylprednisolone twice daily for four weeks. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532107DOI Listing
February 2019
7 Reads

Post-contrast 3D-FLAIR in idiopathic sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol 2019 May 12;276(5):1291-1299. Epub 2019 Feb 12.

NHC Key Laboratory of Hearing Medicine (Fudan University), Fudan University, No. 83 Fenyang Road, Xuhui District, Shanghai, 200031, People's Republic of China.

Purpose: Our study investigated correlations between clinical characteristics, particularly hearing recovery, interval time between onset and three-dimensional fluid attenuation inversion recovery magnetic resonance imaging (3D-FLAIR MRI), and the signal intensity of post-contrast 3D-FLAIR MRI in patients with idiopathic sudden sensorineural hearing loss (SSNHL).

Methods: The study enrolled 100 SSNHL patients. The signal intensities and asymmetry ratios of the inner ear structures, including the cochleae, vestibules and vestibulocochlear nerve, were evaluated and calculated. Read More

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http://link.springer.com/10.1007/s00405-019-05285-z
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http://dx.doi.org/10.1007/s00405-019-05285-zDOI Listing
May 2019
4 Reads

The clinical value of 4-hour delayed-enhanced 3D-FLAIR MR images in sudden hearing loss.

Clin Otolaryngol 2019 05 22;44(3):336-342. Epub 2019 Feb 22.

Department of Radiology, College of Medicine, Hanyang University, Seoul, Korea.

Objective: The aim of this study was to investigate the clinical significance of 4-hour delayed-enhanced 3.0 Tesla (3T) 3D-fluid-attenuated inversion recovery (FLAIR) MR imaging in sudden sensorineural hearing loss (SSNHL).

Study Design: Case series with comparisons. Read More

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http://dx.doi.org/10.1111/coa.13305DOI Listing
May 2019
3 Reads

Peripheral Vestibulopathy Presenting as Acute Vertigo and Spontaneous Nystagmus with Negative Video Head Impulse Test.

Otolaryngol Head Neck Surg 2019 05 22;160(5):894-901. Epub 2019 Jan 22.

1 Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: To analyze acute vertigo showing spontaneous nystagmus with negative video head impulse test (vHIT).

Study Design: Retrospective chart analysis.

Setting: Tertiary referral hospital. Read More

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http://dx.doi.org/10.1177/0194599818825458DOI Listing

Round Window Niche Drilling with Intratympanic Steroid Is a Salvage Therapy of Sudden Hearing Loss.

Audiol Neurootol 2018 10;23(6):309-315. Epub 2019 Jan 10.

Department of Otolaryngology, Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China,

Objective: To explore the effectiveness and safety of round window niche drilling combined with intratympanic methylprednisolone injection for the salvage treatment of sudden sensorineural hearing loss (SSNHL) and its associated tinnitus after failed primary treatment.

Method: SSNHL patients who showed a less than 10-dB improvement of pure-tone average after receiving standard systemic treatment and intratympanic steroid injection were enrolled. All included patients were randomly divided into two groups (control and study). Read More

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http://dx.doi.org/10.1159/000493086DOI Listing
September 2019
21 Reads

Disruption of Gap Junction-Mediated Intercellular Communication in the Spiral Ligament Causes Hearing and Outer Hair Cell Loss in the Cochlea of Mice.

Biol Pharm Bull 2019 ;42(1):73-80

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University.

It is well-known that outer hair cell (OHC) loss occurs in the cochlea of animal models of permanent hearing loss induced by intense noise exposure. Our earlier studies demonstrated the production of hydroxynonenal and peroxynitrite, as well as the disruption of gap junction-mediated intercellular communication (GJIC), in the cochlear spiral ligament prior to noise-induced sudden hearing loss. The goal of the present study was to evaluate the mechanism underlying cochlear OHC loss after sudden hearing loss induced by intense noise exposure. Read More

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http://dx.doi.org/10.1248/bpb.b18-00559DOI Listing
April 2019
2 Reads

"Emergency" Cochlear Implantation in Labyrinthitis Ossificans Secondary to Polyarteritis Nodosa: How to Face a Rare Entity.

J Int Adv Otol 2019 Apr;15(1):156-159

Department of Otolaryngology, University of Pavia, IRCCS Policlinico "S. Matteo" Foundation, Pavia, Italy.

Polyarteritis nodosa (PAN) is a systemic vasculitis affecting the small- and medium-sized arteries that may present with hearing impairment. In rare cases, PAN may be associated with progressive labyrinthitis ossificans (LO), an otologic emergency requiring early cochlear implantation (CI) to restore hearing before the complete, irreversible cochlear ossification. We report the first case in the literature of a patient affected by PAN with bilateral sudden sensorineural hearing loss and rapid LO who underwent "emergency" bilateral simultaneous CI. Read More

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http://dx.doi.org/10.5152/iao.2018.5463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483449PMC
April 2019
13 Reads

Otopathology of Unilateral Cochlear Implantation in Patients With Bilateral Temporal Bone Fracture.

Otol Neurotol 2019 01;40(1):e14-e19

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

Objective: Audiometric outcomes following cochlear implantation (CI) in patients with temporal bone fracture (TBF) are variable and the pathophysiology is not well understood. Herein, we describe otopathologic findings in two such cases to provide insight into pathophysiology and outcomes.

Patients: Two patients had a history of head trauma resulting in bilateral TBF and sudden, profound, sensorineural hearing loss. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939457PMC
January 2019
4 Reads