140,312 results match your criteria Inner Ear Sudden Hearing Loss


Characterization of the Inner and Outer Fiber Layers in the Developing Cerebral Cortex of Gyrencephalic Ferrets.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.

Changes in the cerebral cortex of mammals during evolution have been of great interest. Ferrets, monkeys, and humans have more developed cerebral cortices compared with mice. Although the features of progenitors in the developing cortices of these animals have been intensively investigated, those of the fiber layers are still largely elusive. Read More

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December 2018

There Is No Significant Difference in Fretting and Corrosion at the Trunnion of Metal and Ceramic Heads.

Orthopedics 2018 Dec 11:1-5. Epub 2018 Dec 11.

No study has compared the prevalence of fretting and corrosion at the trunnion of cobalt-chrome (Co-Cr) and zirconia ceramic heads in the same patients. The authors sought to compare the prevalence of fretting and corrosion at the trunnion after total hip arthroplasty with a 32-mm Co-Cr or a 32-mm zirconia ceramic head-on-polyethylene bearing. Isolated revision of the ace-tabular components was performed in 78 patients (156 hips) for polyethylene wear and osteolysis of the acetabulum. Read More

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December 2018

Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

PLoS One 2018 12;13(12):e0207140. Epub 2018 Dec 12.

R&D Alternative Discovery and Development, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestinal crypt cell regeneration. Motivated by the observations that the upregulation of Atoh1 gene expression, through genetic manipulation or pharmacological inhibition of Notch signaling (e.g. Read More

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December 2018

Spatial Patterns and Risk Factors of Bluetongue Virus Infection in Inner Mongolia, China.

Vector Borne Zoonotic Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University , Harbin, PR China .

Bluetongue (BT) is a noncontagious disease affecting domestic and wild ruminants. Outbreaks of BT can cause serious economic losses. Although the causative agent, BT virus (BTV) is endemic in China, a comprehensive analysis has yet to be conducted examining the spatial distribution and risk factors of the virus throughout the Inner Mongolia province. Read More

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December 2018

Vacuum Steam Treatment Eradicates Viable Bretziella fagacearum from Logs Cut from Wilted Quercus rubra.

Plant Dis 2018 Dec 10:PDIS07181252RE. Epub 2018 Dec 10.

Otis Laboratory, USDA Animal and Plant Health Inspection Service, Plant Protection and Quarantine, Buzzards Bay, MA.

Methyl bromide (MB) fumigation is required for U.S. Quercus log exports due to concern over unintentional spread of Bretziella fagacearum. Read More

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December 2018

ICTV Virus Taxonomy Profile: Tristromaviridae.

J Gen Virol 2018 Dec 12. Epub 2018 Dec 12.

1​Department of Microbiology, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris, France.

Tristromaviridae is a family of viruses with linear, double-stranded DNA genomes of 16-18 kbp. The flexible, filamentous virions (400±20 nm×30±3 nm) consist of an envelope and an inner core constructed from two structural units: a rod-shaped helical nucleocapsid and a nucleocapsid-encompassing matrix protein layer. Tristromaviruses are lytic and infect hyperthermophilic archaea of the order Thermoproteales. Read More

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December 2018

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Emory University School of Medicine, United States.

While the role of urea in urine concentration is known, the effect of urea handling by the urea transporters, UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacking both UT-A1 and UT-A3 (UT-A1/A3 KO) have significantly lower serum sodium and higher urinary sodium. Protein expression of renal sodium transporters is unchanged among all three genotypes. Read More

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December 2018

Autism and Religious Beliefs: Clues from Kafka Research.

Authors:
Jerry Stuger

J Autism Dev Disord 2018 Dec 11. Epub 2018 Dec 11.

Independent Researcher, Overvoorde 19, 1082GA, Amsterdam, The Netherlands.

Religious beliefs and faith in high-functioning autistic persons are analyzed by discussing the work and biography of Franz Kafka. It enables researchers to differentiate between how autistic and non-autistic persons experience and express religious beliefs and spiritual issues because Kafka as an autistic person also wrote about these topics in his philosophical-religious writings. This Franz Kafka case study provides additional inner (cognitive) state input to better understand high-functioning autism. Read More

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December 2018

Whole-body low-dose CT recognizes two distinct patterns of lytic lesions in multiple myeloma patients with different disease metabolism at PET/MRI.

Ann Hematol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Institute of Radiology, Padua University School of Medicine, Padua, Italy.

We evaluated differences in density and F-FDG PET/MRI features of lytic bone lesions (LBLs) identified by whole-body low-dose CT (WB-LDCT) in patients affected by newly diagnosed multiple myeloma (MM). In 18 MM patients, 135 unequivocal LBLs identified by WB-LDCT were characterized for inner density (negative or positive Hounsfield unit (HU)), where negative density (HU < 0) characterizes normal yellow marrow whereas positive HU correlates with tissue-like infiltrative pattern. The same LBLs were analyzed by F-FDG PET/DWI-MRI, registering DWI signal with ADC and SUV max values. Read More

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December 2018

Assessing photoreceptor structure in patients with traumatic head injury.

BMJ Open Ophthalmol 2018 24;3(1):e000104. Epub 2018 Nov 24.

Department of Ophthalmology and Visual Sciences, University of WI - Madison, Madison, Wisconsin, USA.

Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally.

Methods And Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure. Read More

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November 2018

Digital Design of Medical Replicas via Desktop Systems: Shape Evaluation of Colon Parts.

J Healthc Eng 2018 14;2018:3272596. Epub 2018 Nov 14.

Dipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università di Roma, via Eudossiana 18, Roma 00184, Italy.

In this paper, we aim at providing results concerning the application of desktop systems for rapid prototyping of medical replicas that involve complex shapes, as, for example, folds of a colon. Medical replicas may assist preoperative planning or tutoring in surgery to better understand the interaction among pathology and organs. Major goals of the paper concern with guiding the digital design workflow of the replicas and understanding their final performance, according to the requirements asked by the medics (shape accuracy, capability of seeing both inner and outer details, and support and possible interfacing with other organs). Read More

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November 2018

Membrane-Located Expression of Thioesterase From Enhances Free Fatty Acid Production With Decreased Toxicity in sp. PCC6803.

Front Microbiol 2018 27;9:2842. Epub 2018 Nov 27.

Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

It has been previously reported that photosynthetic production of extracellular free fatty acids (FFAs) in cyanobacteria was realized by thioesterases (TesA) mediated hydrolysis of fatty acyl-ACP in cytosol and excretion of the FFA outside of the cell. However, two major issues related to the genetically modified strains need to be addressed before the scale-up commercial application becomes possible: namely, the toxicity of FFAs, and the diversity of carbon lengths of fatty acids that could mimic the fossil fuel. To address those issues, we hypothesized that generating FFAs near membrane could facilitate rapid excretion of the FFA outside of the cell and thus decrease toxicity caused by intracellular FFAs in the cytosolic expression of thioesterase. Read More

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November 2018

Not All Green Space Is Created Equal: Biodiversity Predicts Psychological Restorative Benefits From Urban Green Space.

Front Psychol 2018 27;9:2320. Epub 2018 Nov 27.

School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

Contemporary epidemiological methods testing the associations between green space and psychological well-being treat all vegetation cover as equal. However, there is very good reason to expect that variations in ecological "quality" (number of species, integrity of ecological processes) may influence the link between access to green space and benefits to human health and well-being. We test the relationship between green space quality and restorative benefit in an inner city urban population in Bradford, United Kingdom. Read More

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November 2018

Sound Change Integration Error: An Explanatory Model of Tinnitus.

Front Neurosci 2018 27;12:831. Epub 2018 Nov 27.

Department of Otolaryngology, Faculty of Medicine, Kindai University, Osakasayama, Japan.

A growing body of research is focused on identifying and understanding the neurophysiological mechanisms that underlie tinnitus. Unfortunately, however, most current models cannot adequately explain the majority of tinnitus features. For instance, although tinnitus generally appears within minutes after entering a silent environment, most models postulate that tinnitus emerges over a much larger timescale (days). Read More

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November 2018

New roles of NO TRANSMITTING TRACT and SEEDSTICK during medial domain development in Arabidopsis fruits.

Development 2018 Dec 11. Epub 2018 Dec 11.

Unidad de Genómica Avanzada (LANGEBIO), Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Irapuato 36824, Guanajuato, México

The gynoecium, the female reproductive part of the flower, is key for plant sexual reproduction. During its development, inner tissues such as the septum and the transmitting tract tissue, important for pollen germination and guidance, are formed. In Arabidopsis, several transcription factors are known to be involved in the development of these tissues. Read More

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December 2018

Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy.

Bioorg Chem 2018 Dec 4. Epub 2018 Dec 4.

Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 10, Lavrentyev Ave., 630090 Novosibirsk, Russia; Novosibirsk State University, 2, Pirogov Street, 630090 Novosibirsk, Russia.

Fluorescent labeling is a widely-used approach in the study of intracellular processes. This method is becoming increasingly popular for studying small bioactive molecules of natural origin; it allows us to estimate the vital intracellular changes which occur under their influence. We propose a new approach for visualization of the intracellular distribution of triterpene acids, based on fluorescent labeling by fluoresceine isothiocyanate. Read More

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December 2018

Comparison of Pure-Tone Average Methods for Estimation of Hearing Loss Caused by Environmental Exposure to Lead and Cadmium: Does the Pure-Tone Average Method Which Uses Low-Frequency Ranges Underestimate the Actual Hearing Loss Caused by Environmental Lead and Cadmium Exposure?

Audiol Neurootol 2018 Dec 11;23(5):259-269. Epub 2018 Dec 11.

BK21 PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea.

Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. Read More

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December 2018

Adsorption and mechanistic study for phosphate removal by magnetic FeO-doped spent FCC catalysts adsorbent.

Chemosphere 2018 Nov 21;219:183-190. Epub 2018 Nov 21.

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai, 200237, China.

The waste materials utilization has attained increasing attention due to the generation of a large number of spent materials. In the current study, a practical magnetic adsorbent (FeO-doped spent Fluid Catalytic Cracking catalysts, abbreviated as FCC@(Fe)-O) was prepared, liable to be separated. The batch experiments were employed to investigate the phosphate removal behavior. Read More

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November 2018

What's going on at the entrance? A characterisation of the social interface in ant nests.

Behav Processes 2018 Dec 8. Epub 2018 Dec 8.

Unit of Social Ecology, Université libre de Bruxelles, CP231, Bd du Triomphe, 1050, Brussels, Belgium.

Nest entrances are key locations where information about environmental opportunities and constraints are shared between foragers and inner-nest workers. However, despite its functional value, we still lack a detailed characterisation of the interface between the nest and the environment. Here, we identified the social interface in the ant Myrmica rubra as being the population of ants that faced the nest entrance and that received significantly more contacts from returning foragers than other nearby ants. Read More

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December 2018
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Methicillin-resistant Staphylococcus aureus in urban Norway rat (Rattus norvegicus) populations: Epidemiology and the impacts of kill-trapping.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.

Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More

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December 2018

Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China.

Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA was linked to the accumulation of SCFAs. However, the mechanism of SCFAs transport is unknown. Read More

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December 2018
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Moisture-Resistant Mn4+-Doped Core-Shell Structured Fluoride Red Phosphor Exhibiting High Luminous Efficacy for Warm White LEDs.

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 West Yangqiao Road, CHINA.

K2TiF6:Mn4+ is a highly efficient narrow-band emission red phosphor with promising applications in white LEDs and wide-gamut displays. Nevertheless, the poor moisture-resistant property of this material hinders its further commercialization. Herein, we introduce a convenient reverse cation exchange strategy to construct a core-shell structured K2TiF6:Mn4+@K2TiF6 phosphor. Read More

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December 2018

Determining the motivations of family members to undertake cardiopulmonary resuscitation training through grounded theory.

J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.

Capital Medical University, School of Nursing.

Aims: To explore the motivation of family members of patients at high risk for sudden cardiac death for undertaking cardiopulmonary resuscitation (CPR) training.

Background: Home cardiac arrests are associated with poor outcomes because few family members learn CPR. Little is known about factors that motivate family members to participate in CPR training. Read More

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December 2018

The golden paradox - a new heterokont lineage with chloroplasts surrounded by two membranes.

J Phycol 2018 Dec 9. Epub 2018 Dec 9.

School of BioSciences, University of Melbourne, Victoria, 3010, Australia.

A marine, sand-dwelling, golden-brown alga is described from clonal cultures established from a high intertidal pool in southeastern Australia. This tiny, unicellular species, which we call the "golden paradox" (Chrysoparadoxa australica gen. et sp. Read More

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December 2018

Characterisation of a novel method for the production of single-span membrane proteins in Escherichia coli.

Biotechnol Bioeng 2018 Dec 8. Epub 2018 Dec 8.

School of Biosciences, University of Kent, Canterbury, U.K.

The large-scale production and isolation of recombinant protein is a central element of the biotechnology industry and many of the products have proved extremely beneficial for therapeutic medicine. Escherichia coli is the microorganism of choice for the expression of heterologous proteins for therapeutic application, and a range of high-value proteins have been targeted to the periplasm using the well characterised Sec protein export pathway. More recently, the ability of the second mainstream protein export system, the twin-arginine translocase, to transport fully-folded proteins into the periplasm of not only E. Read More

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December 2018

Sowing social inclusion for marginalised residents of a social housing development through a community garden.

Health Promot J Austr 2018 Dec 7. Epub 2018 Dec 7.

School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Australia.

Aim: In addition to food, physical activity, mental health and environmental benefits, community gardens (CGs) provide opportunities for social inclusion and increased social capital. These are particularly important to the socially isolated residents of Social Housing Developments (SHD). This scoping study explored the feasibility of a CG program for tenants of social housing development in inner eastern Melbourne by assessing their interest in, and requirements for, inclusively designed CGs. Read More

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December 2018
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Prenatal development of retina in buffalo (Bubalus bubalis).

Anat Histol Embryol 2018 Dec 10. Epub 2018 Dec 10.

Department of Veterinary Anatomy, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, India.

The development of retina in Indian buffalo (Bubalus bubalis) has not been reported previously. The aim of the present study was therefore to report the major landmarks and the time course in the development of retina. Serial histological sections of Indian buffalo embryos and foetuses were used as group1 (<20. Read More

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December 2018
1 Read

[Management of vestibular schwannomas].

Laryngorhinootologie 2018 Dec 10;97(12):875-896. Epub 2018 Dec 10.

Vestibular schwannomas are benign neoplasms originating from the Schwann cells of the vestibular vestibular nerve of the vestibulocochlear nerve, and rarely from the pars cochlearis. These are tumors that are in contact with the nerve but do not bind the fibers. Benign neoplasms of the Schwann cells of the auditory and equilibrium nerves can also occur primarily in the inner ear and are referred to as intralabyrinthine schwannomas (ILS). Read More

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December 2018
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Generation of Hepatic Tissue Structures Using Multicellular Spheroid Culture.

Methods Mol Biol 2019 ;1905:157-165

Department of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan.

The hepatic functions of the hepatocytes in multicellular spheroid (MCS) are lower than those in the liver. One of the causes is that conventional hepatic MCSs do not reproduce liver-specific microstructures such as hepatic cord. It is necessary to design the inner structure of hepatic MCSs mimicking a structural feature of hepatic cord to represent further hepatic functions. Read More

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January 2019

Acceptability, Feasibility and Uptake of HPV Self-Sampling Among Immigrant Minority Women: a Focused Literature Review.

J Immigr Minor Health 2018 Dec 7. Epub 2018 Dec 7.

Centre for Research on Inner City Health, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada.

This review uncovers the extent to which immigrant and minority women find HPV self-sampling an acceptable and feasible alternative to PAP testing for screening for cervical cancer. A focused literature review was conducted using CINAHL, Medline, Proquest and Pubmed databases to search for content relating to acceptability or feasibility of HPV self-testing for immigrant populations or minorities. 575 prospective relevant papers were included in the final analysis and 28 selected using the inclusion and exclusion criteria. Read More

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December 2018

"Creative Financing": Funding Evidence-Based Interventions in Human Service Systems.

J Behav Health Serv Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive (8012), La Jolla, CA, 92093-0812, USA.

Implementation and sustainment of evidence-based interventions (EBIs) is influenced by outer (e.g., broader environments in which organizations operate) and inner (e. Read More

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December 2018

De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

Hum Genet 2018 Dec 8. Epub 2018 Dec 8.

Hearing and Genes, Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

ATP2B2 encodes the PMCA2 Ca pump that plays an important role in maintaining ion homeostasis in hair cells among others by extrusion of Ca from the stereocilia to the endolymph. Several mouse models have been described for this gene; mice heterozygous for loss-of-function defects display a rapidly progressive high-frequency hearing impairment. Up to now ATP2B2 has only been reported as a modifier, or in a digenic mechanism with CDH23 for hearing impairment in humans. Read More

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December 2018
1 Read

Identification, sexual dimorphism and aspects of the natural history of Sapria himalayana (Rafflesiaceae) on Vietnam's Lang Biang Plateau.

Bot Stud 2018 Dec 10;59(1):29. Epub 2018 Dec 10.

Singapore Botanic Gardens, National Parks Board, 1 Cluny Road, Singapore, 259569, Singapore.

Background: Sapria is a distinctive and narrowly host-specific holoparasitic genus belonging to the Rafflesiaceae. Sapria himalayana, rare throughout its range from NE India, SW China, Thailand to Vietnam, is a little-understood species first recorded for Vietnam in 1959, and only recollected there over half a century later in February 2017. This has facilitated an assessment of its taxonomic identity and our understanding of its morphology and natural history aspects. Read More

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December 2018

Determination of the activity of alkaline phosphatase based on aggregation-induced quenching of the fluorescence of copper nanoclusters.

Mikrochim Acta 2018 Dec 7;186(1). Epub 2018 Dec 7.

Hubei Province Key Laboratory of Regional Development and Environment Response, Wuhan, 430062, China.

A rapid method is described for synthesis of copper nanoclusters (CuNCs) by utilizing L-histidine as the stabilizer and ascorbic acid (AA) as the reductant. The CuNCs display blue-green fluorescence with excitation/emission peaks at 390/485 nm. A sensitive fluorometric assay was worked out for determination of alkaline phosphatase (ALP) activity. Read More

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December 2018
1 Read

GAG content, fiber stiffness, and fiber angle affect swelling-based residual stress in the intact annulus fibrosus.

Biomech Model Mechanobiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Mechanical Engineering, University of California, Berkeley, 5122 Etcheverry Hall, #1740, Berkeley, CA, 94720, USA.

Biological tissues with a high glycosaminoglycan (GAG) content have an excellent ability to swell by absorbing water molecules from the surrounding environment. Our recent work showed that anisotropy in tissue swelling depends on the fiber-network architecture, including fiber angle, fiber stiffness, and lamellae structure. However, that work did not evaluate the effect of in situ boundary conditions, such as the kidney-bean shape of the annulus fibrosus (AF), on swelling behavior. Read More

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December 2018

Supercooled Liquid Serum Physiologic Solution Instantly Crystallized on the Nurse Table Used for Cooling of Periorbital Region During Rhinoplasty.

Aesthetic Plast Surg 2018 Dec 10. Epub 2018 Dec 10.

Institut de Biologie Paris-Seine (IBPS), CNRS, UMR 8256, Inserm ERL U1164, Biological Adaptation and Ageing, Sorbonne Université, 75005, Paris, France.

Introduction: Formation of less periorbital ecchymosis in post-operative period of rhinoplasty is a popular trend. We present the use of instantly crystallizing supercooled serum physiologic solution for periorbital cooling.

Physics Of Supercooling: There are circumstances in which water temperature drops below its freezing point, but no phase transition happens while water remains in the liquid phase. Read More

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December 2018

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5847-5853

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).

Methods: Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Read More

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December 2018

A glossary of user-centered design strategies for implementation experts.

Transl Behav Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.

User-centered design (UCD), a discipline that seeks to ground the design of an innovation in information about the people who will ultimately use that innovation, has great potential to improve the translation of evidence-based practices from behavioral medicine research for implementation in health care settings. UCD is a diverse, innovative field that remains highly variable in terms of language and approaches. Ultimately, we produced a glossary of UCD-related strategies specifically for experts in implementation research and practice, with the goal of promoting interdisciplinary collaboration in implementation efforts. Read More

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December 2018

The Ross procedure versus mechanical aortic valve replacement in young patients: a decision analysis.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiac Surgery, Department of Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Objectives: Our goal was to determine the range of perioperative mortality rates associated with the Ross procedure that results in a life expectancy similar to that seen with mechanical aortic valve replacement (mAVR) in young patients with aortic valve disease.

Methods: A fully probabilistic Markov microsimulation model with 1000 outer loops and 10 000 inner loops was constructed to compare gain in life expectancy and quality-adjusted life years between the index treatment with the Ross procedure versus mAVR for a theoretical cohort of young patients with aortic valve disease. Inputs for early deaths and late complications (death, stroke, bleeding, reoperation) were obtained from a single-centre study of 208 propensity score matched patients. Read More

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December 2018
1 Read

Three-dimensional printing of liver tumors using CT data: proof of concept morphological study.

Rom J Morphol Embryol 2018 ;59(3):885-893

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;

Introduction: Hepatocellular carcinoma (HCC) currently represents a major health concern, mainly for its shifting pre-existing conditions that in turn lead to late diagnosis, thus increasing the mortality rate. An improved training of medical personnel involved in diagnosis, staging and the management of treatment is required.

Aim: We thus aimed to transition tumor view from two-dimensional, on-screen, methods to real, palpatory three-dimensional (3D) representations that can be printed using generally available tools, thus approachable in virtually any medical setting worldwide. Read More

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January 2018
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A novel dual response ratiometric fluorescent probe for the determination of HO and glucose via etching of silver nanoparticles.

Analyst 2018 Dec 11. Epub 2018 Dec 11.

School of Materials Science and Engineering, Linyi University, Linyi 276005, China.

Based on the inner filter effect and charge transfer dual response mechanism, a dual response ratiometric fluorescent probe (D-RFP) with two reversible signal changes for sensing H2O2 and glucose was developed. The D-RFP was proposed by embedding glycine-derived carbon dots (CDs) (λem = 400 nm) into silica nanoparticles and covalently linking CdTe quantum dots (QDs) (λem = 600 nm) onto the surface of silica nanoparticles. When silver nanoparticles (Ag NPs) were mixed with D-RFP, the fluorescence intensity of CDs can be quenched by Ag NPs via the inner filter effect. Read More

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December 2018

Influence of molecular weight on PNIPAM brush modified colloidal silica particles.

Soft Matter 2018 Dec 10. Epub 2018 Dec 10.

Priority Research Centre for Advanced Particle Processing and Transport, University of Newcastle, Callaghan, NSW 2308, Australia.

The effect of molecular weight and temperature on the phase transition and internal structure of poly(N-isopropylacrylamide) brush modified colloidal silica particles was investigated using dynamic light scattering (DLS) and small angle neutron scattering (SANS) between 15 and 45 °C. Dry particle analysis utilising transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) all confirmed the thickness of the polymer brush shell increased as a function of polymerisation time. Hydrodynamic diameter and electrophoretic mobility results revealed that the brush modified particles transitioned from swollen shells to a collapsed conformation between 15 and 35 °C. Read More

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December 2018

Anatomically Based Optimization of Outcomes in Middle Eastern Rhinoplasy.

Plast Reconstr Surg Glob Open 2018 Oct 22;6(10):e1862. Epub 2018 Oct 22.

Faculty of Medicine, Menoufia University, Egypt.

Background: The predominant character in the Middle Eastern noses is the thick skin, weak cartilages, amorphous bulbous nasal tip, and high incidence of postoperative supra-tip swelling, compared with the Caucasian noses. The purpose of this study was to describe some anatomical findings and find techniques to improve outcomes in these patients.

Methods: This is retrospective study in 624 patients of Middle Eastern origin, where the characteristic anatomical findings are described and the surgical endeavors to combat their detrimental effect on the outcomes of rhinoplasty are explained. Read More

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October 2018

Sensitive and high throughput quantification of abscisic acid based on quantitative real time immuno-PCR.

Plant Methods 2018 24;14:104. Epub 2018 Nov 24.

1Hunan Provincial Key Laboratory of Phytohormones and Growth Development, Hunan Agricultural University, Changsha, China.

Background: Abscisic acid (ABA) functions as a stress phytohormone in many growth and developmental processes in plants. The ultra-sensitive determination of ABA would help to better understand its vital roles and action mechanisms.

Results: We report a new sensitive and high throughput quantitative real time immuno-PCR (qIPCR) method based on biotin-avidin linkage system for ABA determination in plants. Read More

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November 2018

Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach.

Evid Based Complement Alternat Med 2018 11;2018:7956503. Epub 2018 Nov 11.

School of Basic Medicine, Inner Mongolia Medical University, Huhehot, China.

GuangZao and RouDouKou ( and , FCN) are one of the most common herb pairs in traditional Mongolian medicine for the treatment of coronary heart disease (CHD). However, evidence for the protective effect of FCN is limited, and its underlying mechanism of action remains unclear. The present study employed a network pharmacology approach to identify the potentially active ingredients and synergistic effects of the herb pair FCN as traditional Mongolian medicine. Read More

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November 2018

Isolation and Functional Analysis of Homolog From .

Front Plant Sci 2018 26;9:1743. Epub 2018 Nov 26.

Key Laboratory of Three Gorges Regional Plant Genetics & Germplasm Enhancement (CTGU)/Biotechnology Research Center, China Three Gorges University, Yichang, China.

() homologs are crucial regulators of flower development in angiosperms. In this study, we isolated the homolog from , a basal angiosperm belonging to the Magnoliaceae. Molecular phylogenetic analysis suggested that was grouped into the PI/GLO lineages of B-class MADS-box gene with the distinctive PI motif. Read More

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November 2018

Draft Genome Sequence of Aquincola tertiaricarbonis MIMtkpLc11, an Aerobic Anoxygenic Phototrophic Bacterial Strain Isolated from Biological Soil Crusts.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Institute for Applied and Environmental Microbiology, Life Sciences College, Inner Mongolia Agriculture University, Huhhot, China.

Aquincola tertiaricarbonis strain MIMtkpLc11 was isolated from biological soil crusts in Inner Mongolia, China. The strain contains photosynthesis gene clusters. Here, we report the draft genome sequence of strain MIMtkpLc11, which comprises 98 contigs (, 233,472 bp) and 5,573 protein-coding sequences. Read More

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September 2018

Pericardial Effusion due to Infliximab Therapy for Ulcerative Colitis.

Case Rep Gastrointest Med 2018 6;2018:4324592. Epub 2018 Nov 6.

Department of Internal Medicine, Medstar Washington Hospital Center, USA.

Ulcerative colitis is characterized by ulcers and inflammation of the inner lining of the gastrointestinal tract. Antitumor necrosis factor alpha (anti-TNF alpha) agents such as infliximab are drugs that have been used for the treatment of ulcerative colitis for decades. Infliximab is known to be associated with various adverse effects including anti-TNF alpha induced lupus (ATIL). Read More

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November 2018

Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice.

Oxid Med Cell Longev 2018 8;2018:5489476. Epub 2018 Nov 8.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.

Purpose: Oxidative stress is a common pathological condition for multiple retinal diseases. Hydrogen peroxide (HO) has been applied as an oxidative stress inducer for the studies. Here, we report the effect of HO exposure to the mouse retina and its underlying mechanism. Read More

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November 2018

Auditory Nomenclature: Combining Name Recognition With Anatomical Description.

Front Neuroanat 2018 23;12:99. Epub 2018 Nov 23.

Department of Biology, The University of Iowa, Iowa City, IA, United States.

The inner ear and its two subsystems, the vestibular and the auditory system, exemplify how the identification of distinct cellular or anatomical elements ahead of elucidating their function, leads to a medley of anatomically defined and recognition oriented names that confused generations of students. Past attempts to clarify this unyielding nomenclature had incomplete success, as they could not yet generate an explanatory nomenclature. Building on these past efforts, we propose a somewhat revised nomenclature that keeps most of the past nomenclature as proposed and follows a simple rule: Anatomical and explanatory terms are combined followed, in brackets, by the name of the discoverer (see Table 1). Read More

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November 2018