1,065 results match your criteria Inner Ear Sudden Hearing Loss


Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1312-1320

a Department of Otolaryngology, Hearing Research Laboratory , University of Miami Miller School of Medicine , Miami , FL, USA.

Hearing loss is the most common neurosensory impairment worldwide. While conductive hearing loss can be managed by surgery, the management of sensorineural hearing loss (SNHL), related to the damage of sensory cells of the inner ear is more challenging to manage medically. Many causes of SNHL such as sudden idiopathic SNHL, Meniere's disease, noise-induced hearing loss, autoimmune hearing loss or hearing loss from exposure to ototoxic substances can benefit from delivery of otoprotective drugs to the inner ear. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573182DOI Listing
December 2019
1 Read

The Natural History of Labyrinthine Hemorrhage in Patients With Sudden Sensorineural Hearing Loss.

Ear Nose Throat J 2019 Mar 26:145561319834862. Epub 2019 Mar 26.

1 Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Taijiang District, Fuzhou, China.

To investigate the application of inner ear 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) in patients with sudden sensorineural hearing loss (SSNHL) accompanied by inner ear hemorrhage. A total of 1252 SSNHL patients who were admitted from January 2010 to April 2018 were included in the study. The patients' clinical features, complete blood counts, coagulation profiles, audiometry data, and MRI scans were retrospectively reviewed. Read More

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http://dx.doi.org/10.1177/0145561319834862DOI Listing

Intratympanic steroid therapy for refractory sudden sensory hearing loss: a 12-year experience with the Silverstein catheter.

Acta Otolaryngol 2019 Feb 22;139(2):111-116. Epub 2019 Feb 22.

a Department of Otorhinolaryngology , CHU Liege , Liège , Belgium.

Background: Sudden sensorineural hearing loss (SSNHL) is commonly encountered in clinical practice.

Aim/objective: Determine if local administration of corticosteroids to the inner ear can improve hearing and speech intelligibility after the failure of conventional treatment for SSNHL loss when administered for 10 days after the onset of the hearing loss in a large cohort of 77 patients.

Materials And Methods: A Silverstein MicroWick™ was placed under local anesthesia and endoscopic control in the round window niche, allowing self-administration of methylprednisolone twice daily for four weeks. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532107DOI Listing
February 2019

Post-contrast 3D-FLAIR in idiopathic sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol 2019 May 12;276(5):1291-1299. Epub 2019 Feb 12.

NHC Key Laboratory of Hearing Medicine (Fudan University), Fudan University, No. 83 Fenyang Road, Xuhui District, Shanghai, 200031, People's Republic of China.

Purpose: Our study investigated correlations between clinical characteristics, particularly hearing recovery, interval time between onset and three-dimensional fluid attenuation inversion recovery magnetic resonance imaging (3D-FLAIR MRI), and the signal intensity of post-contrast 3D-FLAIR MRI in patients with idiopathic sudden sensorineural hearing loss (SSNHL).

Methods: The study enrolled 100 SSNHL patients. The signal intensities and asymmetry ratios of the inner ear structures, including the cochleae, vestibules and vestibulocochlear nerve, were evaluated and calculated. Read More

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http://link.springer.com/10.1007/s00405-019-05285-z
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http://dx.doi.org/10.1007/s00405-019-05285-zDOI Listing
May 2019
1 Read

The clinical value of 4-hour delayed-enhanced 3D-FLAIR MR images in sudden hearing loss.

Clin Otolaryngol 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiology, College of Medicine, Hanyang University, Seoul, Korea.

Objective: The aim of this study was to investigate the clinical significance of 4-hour delayed-enhanced 3.0 Tesla (3T) 3D-fluid-attenuated inversion recovery (FLAIR) MR imaging in sudden sensorineural hearing loss (SSNHL).

Study Design: Case series with comparisons. Read More

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http://dx.doi.org/10.1111/coa.13305DOI Listing
February 2019

Disruption of Gap Junction-Mediated Intercellular Communication in the Spiral Ligament Causes Hearing and Outer Hair Cell Loss in the Cochlea of Mice.

Biol Pharm Bull 2019 ;42(1):73-80

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University.

It is well-known that outer hair cell (OHC) loss occurs in the cochlea of animal models of permanent hearing loss induced by intense noise exposure. Our earlier studies demonstrated the production of hydroxynonenal and peroxynitrite, as well as the disruption of gap junction-mediated intercellular communication (GJIC), in the cochlear spiral ligament prior to noise-induced sudden hearing loss. The goal of the present study was to evaluate the mechanism underlying cochlear OHC loss after sudden hearing loss induced by intense noise exposure. Read More

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http://dx.doi.org/10.1248/bpb.b18-00559DOI Listing

Three-Tesla magnetic resonance imaging of the vestibular endolymphatic space: A systematic qualitative description in healthy ears.

Eur J Radiol 2018 Dec 24;109:77-82. Epub 2018 Oct 24.

Neuroradiology Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy; Postgraduate School of Radiodiagnostics, Università degli Studi di Milano, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Background And Purpose: A detailed knowledge of the normal Magnetic Resonance (MR) anatomy of the vestibular endolymphatic space (ES) could be useful to understand the linkage between endolymphatic hydrops (EH) and Ménière's disease (MD). Our aim was to describe the MR anatomy of the vestibular ES as depicted by MR imaging in healthy ears.

Methods: This report describes a single-center retrospective study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183037
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http://dx.doi.org/10.1016/j.ejrad.2018.10.023DOI Listing
December 2018
14 Reads

Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere's disease and other endolymphatic hydrops-related diseases.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, Japan.

Objective: To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.

Methods: Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Read More

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http://dx.doi.org/10.1016/j.anl.2018.11.008DOI Listing
November 2018
13 Reads

Inner ear and retrocochlear pathology on magnetic resonance imaging for sudden and progressive asymmetrical sensorineural hearing loss.

ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.

Background: In sudden and asymmetrical progressive sensorineural hearing loss (SNHL), magnetic resonance imaging (MRI) is required to evaluate retrocochlear pathology and, with recent advances in MRI techniques, inner ear pathology. Given the limited literature regarding inner ear pathology associated with SNHL, we aimed to assess the incidence of retrocochlear and inner ear pathology, and congenital malformation on MRI in sudden SNHL (SSNHL) and progressive SNHL.

Methods: A total of 987 acoustic neuroma (AN) protocol MRI internal acoustic meatus studies performed at our institution to investigate SNHL between January 2013 and December 2015 inclusive were identified. Read More

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http://dx.doi.org/10.1111/ans.14957DOI Listing
November 2018
1 Read

Disorders of the inner-ear balance organs and their pathways.

Handb Clin Neurol 2018 ;159:385-401

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia; Neurology Department, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Disorders of the inner-ear balance organs can be grouped by their manner of presentation into acute, episodic, or chronic vestibular syndromes. A sudden unilateral vestibular injury produces severe vertigo, nausea, and imbalance lasting days, known as the acute vestibular syndrome (AVS). A bedside head impulse and oculomotor examination helps separate vestibular neuritis, the more common and innocuous cause of AVS, from stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446391650
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http://dx.doi.org/10.1016/B978-0-444-63916-5.00025-2DOI Listing
March 2019
18 Reads

Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage.

Am J Otolaryngol 2019 Mar - Apr;40(2):274-278. Epub 2018 Sep 26.

Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University and Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address:

Objective: To explore the hearing outcomes and prognostic factors in patients with sudden sensorineural hearing loss resulting from inner ear hemorrhage.

Methods: 42 patients (22 male and 20 female) were recruited from January 2016 to December 2017. Intravenous methylprednisolone and/or intratympanic corticosteroid were used as salvage therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183074
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http://dx.doi.org/10.1016/j.amjoto.2018.09.017DOI Listing
September 2018
3 Reads

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques.

MBio 2018 10 30;9(5). Epub 2018 Oct 30.

Office of the Chief Scientists, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. The causal mechanism of hearing loss in LASV-infected patients remains elusive. Here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to LASV exposure control groups in two different studies. Read More

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http://dx.doi.org/10.1128/mBio.01896-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212830PMC
October 2018
8 Reads

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance.

Authors:
Sho Kanzaki

Molecules 2018 Sep 30;23(10). Epub 2018 Sep 30.

Department of Otolaryngology Head and Neck Surgery, School of Medicine, KEIO University, Tokyo 160-8582, Japan.

The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies. Read More

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http://dx.doi.org/10.3390/molecules23102507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222543PMC
September 2018
5 Reads

Audiovestibular Symptoms in Systemic Autoimmune Diseases.

J Immunol Res 2018 19;2018:5798103. Epub 2018 Aug 19.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Read More

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https://www.hindawi.com/journals/jir/2018/5798103/
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http://dx.doi.org/10.1155/2018/5798103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292PMC
November 2018
23 Reads

Sudden hearing loss after cialis (tadalafil) use: A unique case of cochlear hydrops.

Laryngoscope 2018 11 12;128(11):2615-2618. Epub 2018 Sep 12.

Department of Head and Neck Surgery, Los Angeles, California, U.S.A.

We discuss a unique case of sudden sensorineural hearing loss after Cialis (tadalafil) use, a phosphodiesterase 5 (PDE5) inhibitor, and the implication of ipsilateral cochlear hydrops seen on magnetic resonance imaging (MRI). We report a case of a 53-year-old male with unilateral low-frequency sudden sensorineural hearing loss (SSNHL) after ingestion of tadalafil. The SSNHL occurred 1 day after ingestion and was associated with aural fullness and tinnitus. Read More

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http://doi.wiley.com/10.1002/lary.27428
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http://dx.doi.org/10.1002/lary.27428DOI Listing
November 2018
15 Reads

Inner ear barotrauma in divers: an evidence-based tool for evaluation and treatment.

Diving Hyperb Med 2018 Sep;48(3):186-193

Corresponding author: Otolaryngology-Head and Neck Surgery, 1 Jarrett White Road, Tripler Army Medical Center, Hawaii, USA,

Objective: To systematically search the literature for studies evaluating the typical presentation and testing that is performed for divers with inner ear symptoms and then to create a tool for clinicians when evaluating a diver with inner ear symptoms.

Methods: Nine databases, including PubMed/MEDLINE were systematically searched through 31 January 2018. The PRISMA statement was followed. Read More

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http://dx.doi.org/10.28920/dhm48.3.186-193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205852PMC
September 2018
20 Reads

l-Thyroxine does not prevent immunemediated sensorineural hearing loss in autoimmune thyroid diseases.

Acta Otorrinolaringol Esp 2018 Aug 11. Epub 2018 Aug 11.

Department of Otorhinolaryngology, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.

Objective: This is the first report dealing with immune-mediated inner ear disease (IMIED) hearing loss in a group of patients affected with autoimmune thyroid disease (AITD), whose treatment required corticosteroids, despite being treated with levothyroxine. Immunopathology linking the inner ear and the thyroid gland is also presented.

Patients: A total of 220 patients were selected with sensorineural hearing loss (SNHL) of causes other than presbycusis. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.06.001DOI Listing
August 2018
3 Reads

Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols.

Otol Neurotol 2018 Aug;39(7):803-815

Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Germany.

Objective: The use of glucocorticoids for secondary (salvage/rescue) therapy of idiopathic sudden hearing loss (ISSHL), including controlled and uncontrolled studies with intratympanic injections or continuous, catheter mediated applications, were evaluated by means of a meta-analysis in an attempt to define optimal local drug delivery protocols for ISSHL.

Study Design: A total of 30 studies with 33 treatment groups between January 2000 and June 2014 were selected based on sufficiently detailed description of application protocols. Cochlear drug levels were calculated by a validated computer model of drug dispersion in the inner ear fluids based on the concentration and volume of glucocorticoids applied, the time drug remained in the middle ear, and on the specific timing of injections. Read More

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http://Insights.ovid.com/crossref?an=00129492-201808000-0000
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http://dx.doi.org/10.1097/MAO.0000000000001872DOI Listing
August 2018
7 Reads

Spontaneous Labyrinthine Hemorrhage: A Case Series.

Otolaryngol Head Neck Surg 2018 Nov 3;159(5):908-913. Epub 2018 Jul 3.

2 Department of Radiology, Emory University, Atlanta, Georgia, USA.

Objectives: To describe patient characteristics, audiometric outcomes, and magnetic resonance imaging (MRI) signal patterns in patients with suspected labyrinthine hemorrhage.

Study Design: Retrospective review.

Setting: Tertiary medical center. Read More

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http://dx.doi.org/10.1177/0194599818785900DOI Listing
November 2018
3 Reads

Hypertrophic Pachymeningitis of the Internal Auditory Canal: A Rare Case of Unilateral Sudden Sensorineural Hearing Loss.

Ann Otol Rhinol Laryngol 2018 Sep 25;127(9):649-652. Epub 2018 Jun 25.

1 University of Kansas Department of Otolaryngology-Head and Neck Surgery, Kansas City, Kansas, USA.

Objectives: To describe and increase awareness of a rare cause of unilateral sudden sensorineural hearing loss.

Methods: Case report and literature review.

Results: We present a 66-year-old female who suffered left-sided sudden sensorineural hearing loss and dizziness. Read More

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http://dx.doi.org/10.1177/0003489418784051DOI Listing
September 2018
19 Reads

[Clinical analysis of idiopathic sudden sensorineural hearing loss with vertigo and without vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;32(12):920-923

Department of Otorhinolaryngology, Otorhinolaryngology Head and Neck Surgery Hospital of Guangzhou(Guangzhou No.12 Hospital), Otorhinolaryngology Head and Neck Surgery Institute of Guangzhou Medical University, Guangzhou,510620,China.

To explore the clinical characteristics and treatments of patients with idiopathic sudden sensorineural hearing loss(ISSHL) with or without vertigo. One hundred and twenty ISSHL cases were divided into vertigo group (=36) , without vertigo group (=84) , and with benign paroxysmal positional vertigo group (=15). All patients were in regular treatment. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.12.009DOI Listing

MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway.

Biochem Biophys Res Commun 2018 09 18;503(2):665-670. Epub 2018 Jun 18.

Department of Otolaryngology Head and Neck Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jinagsu Province, China.

Ischemia and oxidative stress play crucial roles in the pathophysiology of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and serves an important role in hearing function. The present study was designed to evaluate the effect of MIF on oxygen-glucose deprivation (OGD)-induced ototoxicity and to elucidate its molecular mechanism. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.06.058DOI Listing
September 2018
6 Reads

Prognostic factors regarding the hearing outcome in severe to profound sudden sensorineural hearing loss treated by tympanotomy and sealing of labyrinthine windows after ineffective systemic corticosteroid application.

Eur Arch Otorhinolaryngol 2018 Jul 31;275(7):1749-1758. Epub 2018 May 31.

Department of Otolaryngology, Head and Neck Surgery, St. Elisabeth-Hospital, Ruhr University Bochum, Bleichstr. 15, 44787, Bochum, Germany.

Purpose: Tympanotomy and sealing of labyrinthine membranes has become in some centers used to treat severe to profound sudden sensorineural hearing loss refractory to conservative treatment. The aim of this retrospective study was to determine which preoperative factors influence the likelihood of postoperative recovery according to different audiological assessment criteria.

Methods: The mean final hearing threshold, the hearing improvement, the probability of a complete recovery according to two different classifications, and probability of a significant recovery of 136 adult subjects were studied by univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1007/s00405-018-5023-3DOI Listing
July 2018
6 Reads

[The correlation between normal or abnormal vestibule function and prognosis of the low frequency sudden deafness].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(24):1910-1912;1918

Department of Otolaryngology, Chengdu University Affiliated Hospital, Chengdu, 610081, China.

To study the correlation between prognosis and status of the vestibule functions with the patients of the low frequency sudden deafness (SD). Eighty-eight patients with low frequency SD were enrolled in this study, the cervical vestibular evoked myogenic potential (cVEMP), the ocular VEMP (oVEMP) and caloric test were evaluated. Based upon the results of the test, patients were divided into 4 groups. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.24.010DOI Listing
December 2017

Diagnostics and therapy of sudden hearing loss.

Authors:
Stefan K Plontke

GMS Curr Top Otorhinolaryngol Head Neck Surg 2017 19;16:Doc05. Epub 2018 Feb 19.

Department of Otorhinolaryngology, Head & Neck Surgery, University Medicine Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

This article reviews recent aspects of diagnostics, differential diagnostics, and evidence in systemic and local therapy of idiopathic sudden sensorineural hearing loss (ISSHL). Since a number of disorders can be accompanied by sudden hearing loss, a meaningful and targeted diagnostic strategy is of utmost importance. An important differential diagnosis of sudden hearing loss are intralabyrinthine schwannomas (ILS). Read More

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http://dx.doi.org/10.3205/cto000144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818684PMC
February 2018
1 Read

Should children with an enlarged vestibular aqueduct be restricted from playing contact sports?

Laryngoscope 2018 10 26;128(10):2219-2220. Epub 2018 Feb 26.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

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http://dx.doi.org/10.1002/lary.27119DOI Listing
October 2018
1 Read

Cochlear Implantation in Postmeningitic Deafness.

J Craniofac Surg 2018 May;29(3):e245-e248

Department of Otorhinolaryngology, Bozyaka Teaching and Research Hospital.

Purpose: The aim of this study is to evaluate long-term outcomes of cochlear implantation (CI) in patients with postmeningitic deafness.

Methods: Twenty-seven patients with severe to profound hearing loss due to bacterial meningitis and received CI were the subjects of this study. Surgical findings and long-term audiological performances were evaluated. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004265DOI Listing
May 2018
30 Reads

Evaluation of a transtympanic delivery system in Mus musculus for extended release steroids.

Eur J Pharm Sci 2019 Jan 10;126:3-10. Epub 2018 Jan 10.

Orbis Biosciences, 8006 Reeder Street, Lenexa, KS, USA; The University of Kansas Department of Pharmaceutical Chemistry, 2030 Becker Drive, Lawrence, KS, USA.

Objective: The current investigation evaluated a novel extended release delivery system for treating inner ear diseases. The platform technology consists of a film forming agent (FFA) and microsphere component to localize and extend drug delivery within the ear.

Study Design: Studies evaluated dissolution kinetics of microspheres with multiple encapsulates, testing of a variety of FFAs, and ability to localize to the round window membrane in mice in vivo. Read More

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http://dx.doi.org/10.1016/j.ejps.2018.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039288PMC
January 2019
1 Read

MRI screening of the internal auditory canal: Is gadolinium necessary to detect intralabyrinthine schwannomas?

Am J Otolaryngol 2018 Mar - Apr;39(2):133-137. Epub 2017 Dec 13.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: Non-contrast MRI of the internal auditory canal (IAC) using high-resolution T2WI (T2 weighted image) has been proposed as the primary screening study in patients with sudden or asymmetric sensorineural hearing loss (ASNHL). However, there are concerns that non-contrast MRI may not detect labyrinthine pathology, specifically intralabyrinthine schwannomas (ILSs). The purpose of this study was to determine if non-contrast high-resolution T2WI alone are adequate to exclude these uncommon intralabyrinthine tumors. Read More

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http://dx.doi.org/10.1016/j.amjoto.2017.12.009DOI Listing
September 2018
4 Reads

The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis.

Audiol Neurootol 2017 23;22(4-5):205-217. Epub 2017 Nov 23.

Department of Otolaryngology - Head and Neck Surgery, Northwestern University, Chicago, IL, USA.

Background: A rare subset of sarcoidosis, neurosarcoidosis, is reported to occur in 5-7% of sarcoid patients and can manifest in a variety of ways. The most common are facial paralysis and optic neuritis, less commonly causing cochleovestibulopathy, blindness, anosmia, and other cranial nerve (CN) palsies. The sensory deficit may be severe and psychiatric symptoms may result from the effects of the disease or steroid treatment. Read More

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http://dx.doi.org/10.1159/000481681DOI Listing
November 2017
25 Reads

[Enlarged vestibular aqueduct in a ten-year-old girl].

Ugeskr Laeger 2017 Oct;179(44)

Enlarged vestibular aqueduct (EVA) is a malformation in the inner ear and occurs in approximately 1-12% of the hearing-impaired individuals. A ten-year-old girl was seen at the emergency room (ER) because of sudden hearing loss on the right ear. The patient was known with sudden deafness on the left ear. Read More

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October 2017
7 Reads

The Etiological Relationship Between Migraine and Sudden Hearing Loss.

Otol Neurotol 2017 12;38(10):1411-1414

*Izmir Tepecik Education and Research Hospital Neurology Clinic †Izmir Tepecik Education and Research Hospital Head and Neck Surgery Clinic, Izmir ‡Adiyaman University Education and Research Hospital Head and Neck Surgery Clinic, Adiyaman, Turkey.

Objectives: To investigate the relationship between sudden sensorineural hearing loss (SSNHL) and migraine, assess the prevalence of migraine in patients with idiopathic SSNHL, and determine a possible common vascular etiopathogenesis for migraine and SSNHL.

Study Design: Prospective cohort study.

Setting: Tertiary referral center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001617DOI Listing
December 2017
10 Reads

The role of explorative tympanotomy in patients with sudden sensorineural hearing loss with and without perilymphatic fistula.

Am J Otolaryngol 2018 Jan - Feb;39(1):46-49. Epub 2017 Oct 9.

Department of Otolaryngology - Head and Neck Surgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University in the Negev, Beer-Sheva, Israel. Electronic address:

Purpose: The purpose of this study was to describe the role of explorative tympanotomy in patients with Profound Sudden Sensorineural Hearing Loss (SSNHL) without clinical evidence of perilymphatic or labyrinthine fistula and to compare intraoperative findings with the postoperative hearing outcome.

Study Design: Retrospective study of all patients diagnosed with SSNHL who underwent explorative tympanotomy between 2002 and 2005.

Settings: Tertiary care university-affiliated hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709173057
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http://dx.doi.org/10.1016/j.amjoto.2017.10.006DOI Listing
August 2018
9 Reads

The 'full-blown' MRI of sudden hearing loss: 3D FLAIR in a patient with bilateral metastases in the internal auditory canals.

Neuroradiol J 2018 Feb 19;31(1):39-41. Epub 2017 Oct 19.

1 Neuroradiology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Italy.

We report a case of a 57-year-old man with bilateral masses in the internal auditory canal. The peculiar findings at magnetic resonance imaging with tridimensional fluid-attenuated inversion recovery sequence combined with clinical data provided new insights into understanding the pathophysiology of the hearing loss. Read More

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http://dx.doi.org/10.1177/1971400917736927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789998PMC
February 2018
4 Reads

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy.

Pharmacotherapy 2017 12;37(12):1600-1616

Department of Pharmacy Practice & Science, College of Pharmacy, University of Arizona, Tucson, Arizona.

Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric assessment in order to categorize the hearing loss as conductive, sensorineural, or mixed. Sudden sensorineural hearing loss and autoimmune inner ear disease are acute and subacute forms of sensorineural hypoacusia most likely to be reversed with prompt pharmacological intervention. Read More

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http://dx.doi.org/10.1002/phar.2044DOI Listing
December 2017
31 Reads

Sudden Deafness during Antepartum versus Postpartum Periods.

ORL J Otorhinolaryngol Relat Spec 2017 6;79(5):274-281. Epub 2017 Oct 6.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, ROC.

Objective: This study reviewed our experience in treating sudden deafness in antepartum (pregnant) and postpartum women during the past 2 decades.

Methods: From 1997 to 2016, we have recorded sudden deafness in 16 antepartum (mean age, 32 years) and 3 postpartum (mean age, 31 years) women. Sudden deafness occurred during the 1st, 2nd, and 3rd trimesters in 5, 4, and 7 antepartum women, respectively. Read More

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http://dx.doi.org/10.1159/000478936DOI Listing
July 2018
29 Reads

Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging.

PLoS One 2017 4;12(10):e0186038. Epub 2017 Oct 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.

Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627945PMC
November 2017
17 Reads

The protective effect of autophagy on ischemia/reperfusion-induced hearing loss: implications for sudden hearing loss.

Neuroreport 2017 Dec;28(17):1157-1163

Departments of aOtolaryngology bEmergency, Sun Yat-sen Memorial Hospital cInstitute of Hearing and Speech-Language Science dDepartment of Hearing and Speech Science, Xinhua College, Sun Yat-Sen University, Guangzhou, China.

The present study aimed to determine the effects of ischemia/reperfusion (IR) injury for the carotid system on hearing, particularly, the role of autophagy in this process. Sixty-three Sprague-Dawley rats were divided randomly into three groups: sham surgery animals (S), temporary carotid artery occlusion (ischemia) for 30 min (I30), and temporary carotid artery occlusion for 60 min (I60). Auditory brainstem response measurements were performed on mice. Read More

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http://dx.doi.org/10.1097/WNR.0000000000000897DOI Listing
December 2017
7 Reads

[Clinical study of aged patients with secondary benign paroxysmal positional vertigo].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;52(9):670-675

Department of Otorhinolaryngology Head and Neck surgery, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan 250001, China.

To investigate the clinical features and evaluate the efficacy of manual reduction in treatment of age patients with secondary benign paroxysmal positional vertigo (s-BPPV). Thirty-two cases of aged patients ( the s-BPPV group: including 19 cases of female and 13 males, age from 60 to 86 years old)with secondary benign paroxysmal positional vertigo from Jul. 2013 to Sep. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2017.09.007DOI Listing
September 2017
1 Read

mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.

Proc Natl Acad Sci U S A 2017 09 28;114(37):E7766-E7775. Epub 2017 Aug 28.

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892;

The NLRP3 inflammasome is an intracellular innate immune sensor that is expressed in immune cells, including monocytes and macrophages. Activation of the NLRP3 inflammasome leads to IL-1β secretion. Gain-of-function mutations of result in abnormal activation of the NLRP3 inflammasome, and cause the autosomal dominant systemic autoinflammatory disease spectrum, termed cryopyrin-associated periodic syndromes (CAPS). Read More

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http://dx.doi.org/10.1073/pnas.1702946114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604003PMC
September 2017
33 Reads

An update on drug design strategies to prevent acquired sensorineural hearing loss.

Authors:
Daniel Bodmer

Expert Opin Drug Discov 2017 11 30;12(11):1161-1167. Epub 2017 Aug 30.

a Department of Biomedicine, Head and Neck Surgery , University of Basel Hospital , Basel , Switzerland.

Introduction: Acute sensorineural hearing loss is a dramatic event for the patient. Different pathologies might result in acute sensorineural hearing loss, such as sudden hearing loss, exposure to medications/drugs or loud sound. Current therapeutic approaches include steroids and hyperbaric oxygen in addition to other methods. Read More

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http://dx.doi.org/10.1080/17460441.2017.1372744DOI Listing
November 2017
30 Reads

Characteristic MR findings suggesting presumed labyrinthine hemorrhage.

Acta Otolaryngol 2017 Dec 21;137(12):1226-1232. Epub 2017 Aug 21.

c Department of Otolaryngology-Head and Neck Surgery , Hanyang University Guri Hospital , Guri , Korea.

Objectives: To evaluate the magnetic resonance imaging (MRI) findings of labyrinthine hemorrhage as a cause of sudden sensorineural hearing loss (SSNHL).

Methods: MRI scans of 59 patients with SSNHL were retrospectively analyzed and compared to clinical features and audiometry data. MR images included pre-enhanced T1-weighted, 3D FLAIR volume isometric turbo spin-echo acquisition (VISTA), post-enhanced T1-weighted and 4-h-delayed enhanced FLAIR VISTA, and 3D thin-section proton density-weighted images. Read More

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http://dx.doi.org/10.1080/00016489.2017.1363911DOI Listing
December 2017
84 Reads

Our experience in the treatment of idiopathic sensorineural hearing loss (ISNHL): Effect of combination therapy with HBO₂ and vasodilator infusion therapy.

Undersea Hyperb Med 2016 Nov-Dec;43(7):771-780

Department of Otorhinolaryngology and Maxillofacial Surgery, Third Faculty of Medicine, Charles University, Prague, Military University Hospital, Prague, Czech Republic.

Idiopathic sensorineural hearing loss (ISNHL) is a hearing impairment that occurs suddenly with onset over a period of 24 to 72 hours, affecting at least three adjacent frequencies with hearing loss of 30 decibels or more, caused by damage to the inner ear or auditory nerve without clear reasons. The treatment of ISNHL is still a hot topic. In a retrospective study, we examined 88 patients with ISNHL (2008-2013). Read More

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December 2017
9 Reads

Sudden Bilateral Sensorineural Hearing Loss Following Postpartum Hemorrhage: A Case Report.

Iran J Med Sci 2017 Jul;42(4):404-406

Department of Obstetrics and Gynecology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The prevalence of bilateral sudden sensorineural hearing loss (SSNHL) is less than 5% and the etiology of most cases is unknown. Due to many structural and functional similarities between the kidney and inner ear, many conditions, diseases, and drugs have both renal and cochlear effects and toxicities. There are several reports of SSNHL in patients with CRF, uraemic patient, hemodialysis treatment, and ARF. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523049PMC
July 2017
5 Reads

Sudden hearing loss: an effectivity comparison of intratympanic and systemic steroid treatments.

Eur Arch Otorhinolaryngol 2017 Oct 29;274(10):3585-3591. Epub 2017 Jul 29.

Department of Otorhinolaryngology and Head and Neck Surgery, Koc University Hospital, İstanbul, Turkey.

Corticosteroid treatment has been considered the most effective treatment modality for sudden sensorineural hearing loss so far. Application route of corticosteroids may vary. We have designed a prospective randomized case-controlled clinical trial to evaluate the effectivenesses of the different application routes of steroids in the treatment of SSHL. Read More

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http://link.springer.com/10.1007/s00405-017-4691-8
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http://dx.doi.org/10.1007/s00405-017-4691-8DOI Listing
October 2017
5 Reads

Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss.

Otol Neurotol 2017 09;38(8):1076-1080

*Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya †Department of Otorhinolaryngology, Aichi Children's Health and Medical Center, Obu ‡Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases.

Study Design: Retrospective study.

Setting: University hospital. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001499DOI Listing
September 2017
11 Reads

Intralabyrinthine schwannomas : Surgical management and hearing rehabilitation with cochlear implants.

HNO 2017 Aug;65(Suppl 2):136-148

Department of Radiology, Martin Luther University Halle-Wittenberg, University Medicine Halle, Halle (Saale), Germany.

Intralabyrinthine schwannomas (ILS) are a rare differential diagnosis of sudden hearing loss and vertigo. In an own case series of 12 patients, 6 tumors showed an intracochlear, 3 an intravestibular, 1 a transmodiolar including the cerebellopontine angle (CPA), 1a transotic including the CPA, and 1 a multilocular location. The tumors were removed surgically in 9 patients, whereas 3 patients decided for a "wait-and-test-and-scan" strategy. Read More

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http://dx.doi.org/10.1007/s00106-017-0364-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554299PMC

Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis.

Clin Immunol 2017 10 23;183:24-35. Epub 2017 Jun 23.

Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea; The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Sudden sensorineural hearing loss (S-SNHL) is an inner ear disorder with an abrupt hearing loss occurring <3days. The pathologic mechanism of the disease remains unclear, although autoimmunity has been regarded as one of the suggested causes, especially in bilateral form. In this study, we aimed to provide evidence for the involvement of autoimmunity in bilateral S-SNHL using proteomic approaches such as ProtoArray®, western blotting, immunoprecipitation, and liquid column mass spectrometry for mass screening of candidate antigens and autoantibodies based on the hypothesis that multiple autoantibodies and target antigens must exist in order for autoimmune bilateral S-SNHL to develop. Read More

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http://dx.doi.org/10.1016/j.clim.2017.06.008DOI Listing
October 2017
34 Reads

Intracochlear schwannoma : Tumor removal via subtotal cochleoectomy and partial cochlear reconstruction with preservation of semicircular canal function.

HNO 2017 Aug;65(Suppl 2):158-162

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital and Medical School, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.

We report about a patient, who in 2005, as a 37-year-old, experienced a sudden, mild to moderate, mid-frequency sensorineural hearing loss in the right ear, along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) enhancing lesion in the second turn of the right cochlea after injection of contrast medium. Hearing gradually deteriorated, with complete hearing loss in 2015. Read More

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http://dx.doi.org/10.1007/s00106-017-0348-6DOI Listing

Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide.

Sci Rep 2017 06 2;7(1):2736. Epub 2017 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.

Glucocorticoids have been used to treat hearing loss and vestibular dysfunction for many years. However, some reports have indicated that a subset of patients with these disorders exhibit glucocorticoid insensitivity or resistance. A reduction in histone deacetylase 2 (HDAC2) activity and expression has been reported to play a critical role in glucocorticoid resistance. Read More

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http://dx.doi.org/10.1038/s41598-017-02956-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457401PMC
June 2017
34 Reads