140,410 results match your criteria Inner Ear Meniere Disease Surgical Treatment


Proteomic analysis for phenanthrene-elicited wheat chloroplast deformation.

Environ Int 2018 Dec 11;123:273-281. Epub 2018 Dec 11.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.

The exposure of polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis. Thus, we hypothesize that chloroplast inner structure damage is the reason for leaf chlorosis. This study was conducted with the wheat seedlings exposed to Hoagland nutrient solution containing 1. Read More

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December 2018
2 Reads

Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

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December 2018

Alternative Type II NAD(P)H Dehydrogenases in the Mitochondria of Protists and Fungi.

Protist 2018 Nov 10;170(1):21-37. Epub 2018 Nov 10.

Department of Bioenergetics, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland.

Plants, fungi, and some protists possess a more branched electron transport chain in their mitochondria compared to canonical one. In these organisms, the electron transport chain contains several rotenone-insensitive NAD(P)H dehydrogenases. Some are located on the outer surface, and others are located on the inner surface of the inner mitochondrial membrane. Read More

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November 2018

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology and Biotechnology "Charles Darwin", La Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; Pasteur Institute-Cenci Bolognetti Foundation, Viale Regina Elena, 291, 00100 Rome, Italy.. Electronic address:

Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. Read More

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December 2018

How many cadherins do human endothelial cells express?

Cell Mol Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, C/Nicolás Cabrera 1, Cantoblanco, 28049, Madrid, Spain.

The vasculature is the paradigm of a compartment generated by parallel cellular barriers that aims to transport oxygen, nutrients and immune cells in complex organisms. Vascular barrier dysfunction leads to fatal acute and chronic inflammatory diseases. The endothelial barrier lines the inner side of vessels and is the main regulator of vascular permeability. Read More

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December 2018

Translational research on clinically failed zirconia implants.

Dent Mater 2018 Dec 11. Epub 2018 Dec 11.

HEPIA, University of Applied Sciences - Western Switzerland (HES-SO), Geneva, Switzerland. Electronic address:

Objectives: To provide fractographic analysis of clinically fractured zirconia implants recovered with their cemented crown. To calculate bending moments, corresponding stress and crack onset location on the implant's fracture surface using a mathematical model integrating spatial coordinates of the crown-implant part and occlusal loading obtained from 2D and 3D images.

Methods: 15 fractured zirconia implants parts (11 posterior and 4 anterior) with their all- ceramic crowns still cemented on it were recovered. Read More

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December 2018

Geometric Effect for Biological Reactors and Biological Fluids.

Bioengineering (Basel) 2018 Dec 13;5(4). Epub 2018 Dec 13.

Department of Physics, Kyushu University, Fukuoka 819-0395, Japan.

As expressed "God made the bulk; the surface was invented by the devil" by W. Pauli, the surface has remarkable properties because broken symmetry in surface alters the material properties. In biological systems, the smallest functional and structural unit, which has a functional bulk space enclosed by a thin interface, is a cell. Read More

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December 2018

Effects of 5-Aza on p-Y1472 NR2B related to learning and memory in the mouse hippocampus.

Biomed Pharmacother 2019 Jan 5;109:701-707. Epub 2018 Nov 5.

Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Inner Mongolia, People's Republic of China; Biomedicine Research Center, Basic Medical College and Baotou Medical College of Neuroscience Institute, Baotou Medical College, Inner Mongolia, People's Republic of China; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:

Background: We have previously reported that 5-Aza-2-deoxycytidine (5-Aza-cdR) can repress protein serine/threonine phosphatase-1γ (PP1γ) expression and activity in the mouse hippocampus and affect the behaviour of mice in a water maze. It is well known that the phosphorylation of N-methyl-d-aspartate receptor 2B subunit (NR2B) plays a role in behaviour. In this study, we examined whether 5-Aza-cdR affects NR2B phosphorylation at tyrosine 1472 (p-Y1472 NR2B) and whether it affected the responses of the mice in a passive avoidance test. Read More

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January 2019

In vitro breeding: application of embryonic stem cells to animal production.

Biol Reprod 2018 Dec 14. Epub 2018 Dec 14.

Department of Animal Science, University of California, Davis, CA.

Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation blastocysts. For decades, attempts to efficiently derive ESCs in animal livestock species have been unsuccessful, but this goal has recently been achieved in cattle. Together with the recent reconstitution of the germ cell differentiation processes from ESCs in mice, these achievements open new avenues for the development of promising technologies oriented toward improving health, animal production and the environment. Read More

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December 2018
1 Read

Competitive adsorption of heavy metals in aqueous solution onto biochar derived from anaerobically digested sludge.

Chemosphere 2018 Dec 7;219:351-357. Epub 2018 Dec 7.

State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China. Electronic address:

Heavy metals often coexist in contaminated wastewater systems and their competitive behavior could affect the adsorption capacity of biochar. Till now, the competitive adsorption of heavy metals by biochar derived from anaerobically digested sludge has never been reported. In this work, biochar from anaerobically digested sludge was synthesized and characterized to explore the competitive behavior of widely co-existed Pb(II) and Cd(II). Read More

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December 2018
1 Read

Prolonging food shelf-life by dual actives release from multi-layered polymer particles.

Colloids Surf B Biointerfaces 2018 Dec 4;175:281-290. Epub 2018 Dec 4.

Department of Materials Science and Engineering, Indian Institute of Technology, Delhi, 110016, India. Electronic address:

Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. Read More

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December 2018
1 Read

A modified QWASI model for fate and transport modeling of Zn and Pb in a shallow lake during the ice-free period.

Sci Total Environ 2018 Dec 3;657:577-584. Epub 2018 Dec 3.

Water Conservancy and Civil Engineering College, Inner Mongolia Agricultural University, Hohhot 010018, China.

Heavy metal pollution in lakes is becoming increasingly of interest to researchers. Because heavy metals have high mobility and do not degrade, they migrate easily between different environmental mediums through processes such as suspended solids deposition, sediment resuspension, and diffusion, among others. These processes are particularly pronounced in shallow lakes since the hydrodynamism is higher in bodies of water with minimal depth. Read More

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December 2018

Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos.

Cell 2018 Dec;175(7):1887-1901.e18

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China; University of Chinese Academy of Sciences, 100049 Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101 Beijing, China. Electronic address:

In early mammalian embryos, it remains unclear how the first cell fate bias is initially triggered and amplified toward cell fate segregation. Here, we report that a long noncoding RNA, LincGET, is transiently and asymmetrically expressed in the nucleus of two- to four-cell mouse embryos. Overexpression of LincGET in one of the two-cell blastomeres biases its progeny predominantly toward the inner cell mass (ICM) fate. Read More

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December 2018
3 Reads

3D simulation of solutes concentration in urinary concentration mechanism in rat renal medulla.

Math Biosci 2018 Dec 11. Epub 2018 Dec 11.

Division of General Internal Medicine, Department of Medicine, Toronto General Hospital, Toronto.

In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Read More

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December 2018

Enhancing Electrochemical Efficiency of Hydroxyl Radical Formation on Diamond Electrodes by Functionalization with Hydrophobic Monolayers.

Langmuir 2018 Dec 14. Epub 2018 Dec 14.

Electrochemical formation of high-energy species such as hydroxyl radical in aqueous media is inefficient because oxidation of HO to form O is a more thermodynamically favorable reaction. Boron-doped diamond (BDD) is widely used as an electrode material for generating ∙OH radicals because it has a very large kinetic overpotential for O production, thus increasing electrochemical efficiency for ∙OH production. Yet, the underlying mechanisms of O and ∙OH production at diamond electrodes are not well understood. Read More

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December 2018

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5893-5903

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To investigate the nonperfused areas (NPAs) in each subfield segmented by large arterioles on wide-field swept-source optical coherence tomography angiography (SS-OCTA) images in diabetic retinopathy.

Methods: We retrospectively reviewed 101 consecutive eyes of 67 patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), for whom 12 × 12-mm SS-OCTA images centered on the optic disc were acquired. Both eyes were included in 34 patients. Read More

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December 2018

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.

PLoS One 2018 14;13(12):e0208782. Epub 2018 Dec 14.

Institute of Systems Biology, Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain.

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made possible to know where, in the metabolic network, adaptive selection has acted and where purifying selection is more or less strong and efficient. Read More

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December 2018

[Observation on pollinosis with vegetable food allergy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1779-1783

Department of Allergy, Beijing Shijitan Hospital, Affiliated to Capital Medical University, Beijing, 100038, China.

To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Read More

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December 2018
2 Reads

[MicroRNA and sensorineural hearing loss].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1523-1526

Hearing loss caused by disorders throughout the cochlea or auditory pathway called sensorineural hearing loss. The etiology of sensorineural deafness is complex and diverse, and the sensory epithelial cell damage of the inner ear spiral is the main pathological change. MicroRNAs play a role in the regulation of gene expression by inhibiting or degrading the mRNA of target genes. Read More

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October 2018

Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography.

Korean J Ophthalmol 2018 Dec;32(6):506-516

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.

Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More

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December 2018
3 Reads

MMP-14 single-nucleotide polymorphisms are related to steroid-induced osteonecrosis of the femoral head in the population of northern China.

Mol Genet Genomic Med 2018 Dec 12. Epub 2018 Dec 12.

The 2nd Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Background: Osteonecrosis of the femoral head (ONFH) is a refractory disease which frequently occurs in young and middle-aged people. Recent studies indicated that MMP-14 played an important role in the development of chondrocytes, metabolism of osteoblasts as well as fate decision of hypertrophic chondrocytes. The aim of this study was to investigate the association between polymorphisms of MMP-14 and steroid-induced osteonecrosis of the femoral head in the Chinese population. Read More

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December 2018

PLGA/PLCA casting and PLGA/PDPA electrospinning bilayer film for prevention of postoperative adhesion.

J Biomed Mater Res B Appl Biomater 2018 Dec 13. Epub 2018 Dec 13.

Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Postoperative adhesion is a common complication and preventing adhesions during or immediately after operation is particularly important. The application of solid barrier materials represents the most successful clinical strategy to prevent postoperative adhesion. However, a simple physical barrier effect might be insufficient in preventing adhesion satisfactorily. Read More

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December 2018

Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle.

Photochem Photobiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Engineering, Muroran Institute of Technology, Muroran, 050-8585, Japan.

Archaerhodopsins (ARs) is one of the members of microbial rhodopsins. Threonine 164 (T164) and serine 165 (S165) residues of the AR from Halorubrum sp. ejinoor (HeAR) are fully conserved in ARs, although they are far from the proton transfer channel and the retinal Schiff base, and are likely involved in a hydrogen bonding network at the end of the Helix E where most microbial rhodopsins assume a "bent structure". Read More

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December 2018

Tmem30a deficiency leads to retinal rod bipolar cell degeneration.

J Neurochem 2018 Dec 12. Epub 2018 Dec 12.

Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine (PE) concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPases called PS flippases. The proper transport and function of PS flippases require a β-subunit transmembrane protein 30A (TMEM30A). Read More

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December 2018
1 Read

Long-term changes in vocal function after supracricoid partial laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan.

Background: The purpose of this study was to assess changes in vocal function over time following supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP).

Methods: A total of 17 patients who underwent SCL-CHEP for laryngeal squamous cell carcinoma between 2007 and 2015 were reviewed. We examined maximum phonation time (MPT), mean airflow rate (MFR), voice intensity, the grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, Voice Handicap Index-10 (VHI-10), and voice-related quality of life (V-RQOL) scores. Read More

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December 2018

A long noncoding RNAs signature to improve survival prediction in endometrioid endometrial cancer.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: The dysregulation of long noncoding RNAs (lncRNAs) has been reported to be correlated to carcinogenesis and cancer progression. Endometrial cancer (EC), arising from the endometrium or the inner lining of the uterus, is one of the most common gynecological malignancies. We aim to explore the prognostic value of the lncRNAs in patients with endometrioid endometrial cancer (EEC) and to identify the potential lncRNA signature for predicting survival of patients with EEC. Read More

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December 2018

Z-scores of the fetal trachea and bronchial dimension.

Prenat Diagn 2018 Dec 12. Epub 2018 Dec 12.

Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Objective: To develop Z-scores for the trachea and main bronchi in normal fetuses.

Methods: This was a prospective cross-sectional study in 823 normal singleton fetuses. The tracheal diameter immediately proximal to the bifurcation as well as the left and right main bronchial diameters were measured from their inner to inner edge in the coronal view. Read More

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December 2018

Genetic variants in COL11A2 of lumbar disk degeneration among Chinese Han population.

Mol Genet Genomic Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Spine (Thoracic and Vertebra), The Second Affiliated Hospital of Inner Mongolia University, Hohhot, China.

Background: Lumbar disk disease (LDD) is a common musculoskeletal disorder. Several predisposing genetic and environmental risk factors have been established for symptomatic LDD.

Methods: We conducted a case-control association study to investigate the role of the COL11A2 gene in LDD. Read More

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December 2018
1 Read

LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.

J Exp Clin Cancer Res 2018 Dec 14;37(1):316. Epub 2018 Dec 14.

College of Laboratory Medicine, Dalian Medical University, 9 Lushunnan Road Xiduan, Dalian, 116044, Liaoning Province, China.

Background: Long non-coding RNAs (LncRNAs) emerging as pivotal marker in the procession of cancer, including colorectal cancer (CRC). Abnormal O-glycosylation is a crucial modification during cancer malignancy. The aim of this work is to analyze the alteration of O-glycosylation involved in CRC progression. Read More

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December 2018

Gatekeeper Improves Voluntary Contractility in Patients With Fecal Incontinence.

Surg Innov 2018 Dec 14:1553350618818924. Epub 2018 Dec 14.

1 Proctology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Gatekeeper (GK) has shown to be safe and effective in patients with fecal incontinence (FI). We aimed to understand its mechanism of action by comparing pre- and post-implant change in the external anal sphincter (EAS) contractility.

Methods: Study of EAS contractility was conducted in 16 FI females (median age = 69 years) before and after implant of 6 GK prostheses. Read More

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December 2018

A stakeholder analysis of community-led collaboration to reduce health inequity in a deprived neighbourhood in South Korea.

Glob Health Promot 2018 Dec 14:1757975918791517. Epub 2018 Dec 14.

3 BK21PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, South Korea.

Intersectoral collaboration amongst health and other sectors, as well as between government and non-governmental organisations, has been highlighted as a way to improve health equity. We used a mixed-methods approach to assess collaborative relationships between multiple government sectors and civil society and to suggest possible health promotion interventions and policy alternatives for the urban poor in deprived neighborhoods. A total of 18 participants involved in health promotion interventions and policy processes related to the inner-city area of Seoul were recruited using purposive sampling methods. Read More

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December 2018

Punctate Inner Choroidopathy and Choroidal Neovascularization in Korean Patients.

Ocul Immunol Inflamm 2018 Dec 14:1-6. Epub 2018 Dec 14.

a Department of Ophthalmology, The Institute of Vision Research , Yonsei University College of Medicine , Seoul , South Korea.

Purpose: To describe the clinical features and outcomes of punctate inner choroidopathy (PIC) in Korean patients Methods: We retrospectively reviewed the medical records of patients with PIC between 2004 and 2015. The main outcome measures included best-corrected visual acuity (BCVA), presence of choroidal neovascularization (CNV), and optical coherence tomography findings. Patients with and without CNV were compared. Read More

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December 2018

Measurement of Nanoparticle-Induced Mitochondrial Membrane Potential Alterations.

Authors:
Salik Hussain

Methods Mol Biol 2019 ;1894:123-131

Department of Physiology and Pharmacology, Robert C. Byrd Health Science Center, School of Medicine,, West Virginia University, Morgantown, WV, USA.

Mitochondria hold a critical role in cell metabolism and homeostasis. Mitochondrial injury plays central part in deciding cell fate especially in programmed cell death pathways. Various nanomaterials lead to different cell death modalities by inducing mitochondrial injury. Read More

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January 2019

A pentadentate member of the picolinate family for Mn(ii) complexation and an amphiphilic derivative.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

Universidade da Coruña, Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Facultade de Ciencias, 15071, A Coruña, Galicia, Spain.

We report a pentadentate ligand containing a 2,2'-azanediyldiacetic acid moiety functionalized with a picolinate group at the nitrogen atom (H3paada), as well as a lipophylic derivative functionalized with a dodecyloxy group at position 4 of the pyridyl ring (H3C12Opaada). The protonation constants of the paada3- ligand and the stability constant of the Mn(ii) complex were determined using a combination of potentiometric and spectrophotometric titrations (25 °C, 0.15 M NaCl). Read More

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December 2018

Application in the World of Understanding: Researchers' Experiences of Participation in Reflective Dialogues.

Glob Qual Nurs Res 2018 Jan-Dec;5:2333393618815006. Epub 2018 Dec 4.

Åbo Akademi University, Vaasa, Finland.

The aim of this study was to describe researchers' experiences of participation in reflective dialogues through a hermeneutic application research approach. The aim was also to describe their perspectives on application, that is, the inner appropriation and application of theory into practice and vice versa. Twenty-one clinical coresearchers and four scientific researchers participated in reflective dialogues in a project on ethical sustainable caring cultures, in which an application research approach was used. Read More

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December 2018

Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma.

Oncol Lett 2018 Dec 3;16(6):7123-7130. Epub 2018 Oct 3.

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China.

Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. Read More

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December 2018

Single-stage reconstruction of large defect of oral commissure and lips by submental artery island flap.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):222-224

Department of Gynaecology and Obstetrics, Apollo Institute of Medical Sciences, Hyderabad, Telangana, India.

Large defect of the lip and buccal mucosa created due to wide resection of the cancer is difficult to reconstruct and always a challenge. Such defects are complex as there is loss of outer skin, muscle, soft tissue, and inner mucosal lining. We report the use of submental artery island flap (SAIF) in the reconstruction of a large defect of oral commissure and buccal mucosa in a 70-year-old female with the diagnosis of verrucous carcinoma. Read More

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December 2018

Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul 05006, South Korea. Electronic address:

Additional sex comb-like1 (Asxl1) is known as a chromatin modulator that plays dual functions in transcriptional regulation depending on the cell type. Recent studies using Asxl1 knockout mice revealed that Asxl1 is important for the proliferation and differentiation of hematopoietic progenitor cells, and the development of organs. Although we previously reported Asxl1 as a Sox2 target gene, its function in embryonic stem cells (ESCs) remains largely unknown. Read More

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December 2018

UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.

Authors:
Zhi Liu Lijun Xu

BMB Rep 2018 Dec 14. Epub 2018 Dec 14.

Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.

Ubiquitin-conjugating enzyme E2S (UBE2S), a family of E2 protein in the ubiquitination process, is involved in development of various cancers. However, its role in lung adenocarcinoma, has not been well elucidated. In this report, we attempted to investigate expression and function of UBE2S in lung adenocarcinoma. Read More

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December 2018
3 Reads

The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells.

Stem Cell Res Ther 2018 Dec 13;9(1):346. Epub 2018 Dec 13.

Department of Ophthalmology of Shanghai Tenth People's Hospital, and Tongji Eye Institute, Tongji University School of Medicine, Shanghai, 200072, China.

Background: Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underlying regulation mechanisms remain elusive.

Methods: Adult mouse neural RPCs (mNRPCs) were isolated and amplified with the combination of basic fibroblast growth factor (bFGF) and glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021. Read More

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December 2018

Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution.

BMC Struct Biol 2018 Dec 13;18(1):17. Epub 2018 Dec 13.

School of Biology, Faculty of Biology Medicine and Health, Michael Smith Building, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: P-glycoprotein (ABCB1) is an ATP-binding cassette transporter that plays an important role in the clearance of drugs and xenobiotics and is associated with multi-drug resistance in cancer. Although several P-glycoprotein structures are available, these are either at low resolution, or represent mutated and/or quiescent states of the protein.

Results: In the post-hydrolytic state the structure of the wild-type protein has been resolved at about 8 Å resolution. Read More

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December 2018

Comparative evaluation of mesenchymal stromal cells from umbilical cord and amniotic membrane in xeno-free conditions.

BMC Cell Biol 2018 Dec 13;19(1):27. Epub 2018 Dec 13.

Department of Rheumatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Pvovince, China.

Background: Within the past years, umbilical cord (UC) and amniotic membrane (AM) expanded in human platelet lysate (PL) have been found to become increasingly candidate of mesenchymal stromal cells (MSCs) in preclinical and clinical studies. Different sources of MSCs have different properties, and lead to different therapeutic applications. However, the similarity and differences between the AMMSCs and UCMSCs in PL remain unclear. Read More

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December 2018

Plays a Critical Role in Anther Wall Programmed Cell Death and Pollen Development in Rice.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Key Laboratory for Zhejiang Super Rice Research and State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, China.

In flowering plants, ideal male reproductive development requires the systematic coordination of various processes, in which timely differentiation and degradation of the anther wall, especially the tapetum, is essential for both pollen formation and anther dehiscence. Here, we show that , a conserved glycerol-3-phosphate acyltransferase gene, plays a critical role in regulating anther wall degradation and pollen exine formation. The mutant had defective synthesis of Ubisch bodies, delayed programmed cell death (PCD) of the inner three anther layers, and abnormal degradation of micropores/pollen grains, resulting in failure of pollen maturation and complete male sterility. Read More

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December 2018
1 Read

Mitochondrial Membrane Dynamics-Functional Positioning of OPA1.

Antioxidants (Basel) 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion. One of them, optic atrophy 1 (OPA1), is the mitochondrial inner membrane remodeling protein. Read More

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December 2018

Supramolecular Modification of ABC Triblock Terpolymers in Confinement Assembly.

Nanomaterials (Basel) 2018 Dec 10;8(12). Epub 2018 Dec 10.

Physical Chemistry, University of Duisburg-Essen, 47057 Duisburg, Germany.

The self-assembly of AB diblock copolymers in three-dimensional (3D) soft confinement of nanoemulsions has recently become an attractive bottom up route to prepare colloids with controlled inner morphologies. In that regard, ABC triblock terpolymers show a more complex morphological behavior and could thus give access to extensive libraries of multicompartment microparticles. However, knowledge about their self-assembly in confinement is very limited thus far. Read More

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December 2018

Chemical Characterization and Hypoglycaemic Activities In Vitro of Two Polysaccharides from by Submerged Culture.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Polysaccharides from the fungus have been found to be biologically active. In this study, we carried out a preliminary characterisation and assessment of the hypoglycaemic activities of the polysaccharides (IOEP) from obtained by liquid fermentation. Two polysaccharides, IOEP1 and IOEP2, were isolated from IOEP. Read More

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December 2018

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Point mutations in genes encoding isoforms of skeletal muscle tropomyosin may cause nemaline myopathy, cap myopathy (Cap), congenital fiber-type disproportion (CFTD), and distal arthrogryposis. The molecular mechanisms of muscle dysfunction in these diseases remain unclear. We studied the effect of the E173A, R90P, E150A, and A155T myopathy-causing substitutions in γ-tropomyosin (Tpm3. Read More

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December 2018

Bearing Fault Diagnosis Using an Extended Variable Structure Feedback Linearization Observer.

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

Department of Electrical, Electronics and Computer Engineering, University of Ulsan, Ulsan 680⁻749, Korea.

The rolling element bearing is a significant component in rotating machinery. Suitable bearing fault detection and diagnosis (FDD) is vital to maintaining machine operations in a safe and healthy state. To address this issue, an extended observer-based FDD method is proposed, which uses a variable structure feedback linearization observer (FLO). Read More

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December 2018

A New Disturbance Feedforward Control Method for Electro-Optical Tracking System Line-Of-Sight Stabilization on Moving Platform.

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

Institute of Optics and Electronics, Chinese Academy of Science, Chengdu 610209, China.

A feedforward control was proposed based on the decoupling of target movement and disturbance from gyro signals to improve the stabilization precision of line-of-sight (LOS) for an electro-optical tracking system (EOTS) on a moving platform. Signals measured by gyros mounted on gimbal consist of target movement and disturbance. To remove target movement and obtain middle and high frequency disturbance velocity, the gyro signals were filtered by a high pass filter. Read More

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December 2018

Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 12808 Prague, Czech Republic.

Mitochondrial protein quality control is crucial for the maintenance of correct mitochondrial homeostasis. It is ensured by several specific mitochondrial proteases located across the various mitochondrial subcompartments. Here, we focused on characterization of functional overlap and cooperativity of proteolytic subunits AFG3L2 (AFG3 Like Matrix AAA Peptidase Subunit 2) and YME1L (YME1 like ATPase) of mitochondrial inner membrane AAA (ATPases Associated with diverse cellular Activities) complexes in the maintenance of mitochondrial structure and respiratory chain integrity. Read More

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December 2018