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Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):662-667

Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital, Beijing 100123, China.

Objective: To investigate the postoperative anxiety and its relationship with life quality in patients with Ménière's diseases.
 Methods: A total of 68 patients with Ménière's disease, who received the treatment of endolymphatic sac decompression from 2010 to 2016, were enrolled. They finished two scales (the self-rating anxiety scale and the quality of life questionnaire for endolymphatic sac decompression of Ménière's disease) by snail mail. Read More

Am J Otolaryngol 2018 Nov - Dec;39(6):731-736. Epub 2018 Aug 1.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; University of Massachusetts Medical School, Worcester, MA, USA; Department of Otolaryngology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA, USA. Electronic address:

Purpose: Effective operative approaches for the treatment of refractory vertigo in Meniere's disease are invasive. Vestibular neurectomy can preserve hearing and has been shown to be effective; however, current approaches require an extensive craniotomy. Transcanal endoscopic approaches to the internal auditory canal (IAC) with cochlear preservation have been recently described and may offer a minimally invasive approach to selectively sectioning the distal vestibular nerves while preserving residual hearing. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):138-142

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education Beijing,100730,China.

To investigate the long-term efficacy of endolymphatic sac mastoid drainage for Ménière disease.Data from 26 patients diagnosed with MD strictly meeting the criteria issued by " Guideline of diagnosis and treatment of Meniere disease(2017)" from 2006 to 2015 were analyzed in this study.Endolymphatic sac mastoid shunt surgery was performed for each patient. Read More

Acta Otolaryngol 2018 Mar;138(3):304-309

J Multidiscip Healthc 2018 22;11:1-11. Epub 2017 Dec 22.

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. Read More

Otol Neurotol 2017 12;38(10):1484-1489

*Department of Otolaryngology-Head and Neck Surgery †Department of General Surgery, Detroit Medical Center, Michigan State University, Detroit ‡Department of Radiology, Michigan State University, East Lansing §Department of Otology, Neurotology, and Skull Base Surgery, Michigan Ear Institute, Farmington Hills, Michigan.

Objective: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls.

Study Design: Retrospective chart review.

Setting: Two tertiary referral centers. Read More

Auris Nasus Larynx 2018 Jun 31;45(3):427-432. Epub 2017 Jul 31.

Department of Otolaryngology, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Objective: To evaluate the histopathologic changes in tympanic membranes (TMs) with ventilation tubes (VTs).

Methods: In this retrospective human temporal bone study our overall study group included 4 subgroups of TMs from deceased donors as follows: 24 with a history of VT insertion for chronic otitis media with effusion (COME-VT); 5 with a history of VT insertion for Meniere's disease (MD-VT); 33 without a history of VT insertion for chronic otitis media with effusion (COME); and 14 without a history of VT insertion for Meniere's disease (MD). We classified the extent of migration of the outer keratinized squamous epithelium onto the inner surface of TM perforations and noted the presence and location of tympanosclerosis, of atrophy, of perforation, and/or of cholesteatoma formation. Read More

Auris Nasus Larynx 2018 Jun 29;45(3):393-398. Epub 2017 Jul 29.

Department of Otolaryngology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, Japan. Electronic address:

Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. Read More

Neurol Sci 2017 May;38(Suppl 1):193-196

Department of Neurosciences, Reproductive Sciences and Odontostomatology, Headache Centre, University of Naples "Federico II", Via Pansini, 5, 80131, Naples, Italy.

Idiopathic intracranial hypertension is characterized by raised intracranial pressure (ICP) without any underlying pathology, presenting with (IIH) or without papilledema (IIHWOP). Headache, often on daily basis, is the most frequent symptom. Among audiovestibular symptoms, tinnitus and dizziness are commonly reported, while vertigo and hearing impairment are infrequent reports. Read More

Laryngorhinootologie 2017 Apr 12;96(S 01):S209-S229. Epub 2017 May 12.

Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum am St. Elisabeth-Hospital Bochum.

Vertigo is not a well defined symptom but a heterogenous entity diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine and primary care physicians. Most vertigo syndroms have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe the development of surgical therapy for hydropic inner ear diseases, Menière disease, dehiscence syndroms, perilymphatic fistulas, and benign paroxysmal vertigo. Read More

Int Arch Otorhinolaryngol 2017 Apr;21(2):179-183

Otorhinolaryngology and Neurotology, Grupo Otológico Médica Sur, Neurociencias Clínicas e Investigación, Ciudad de México, DF, Mexico.

 The endolymphatic sac is thought to maintain the hydrostatic pressure and endolymph homeostasis for the inner ear, and its dysfunction may contribute to the pathophysiology of Ménière's disease. Throughout the years, different surgical procedures for intractable vertigo secondary to Ménière's disease have been described, and though many authors consider these procedures as effective, there are some who question its long-term efficacy and even those who think that vertigo control is achieved more due to a placebo effect than because of the procedure itself.  To review the different surgical procedures performed in the endolymphatic sac for the treatment of Ménière's disease. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;31(4):272-276

Department of Otolaryngology Head and Neck Surgery, General Hospital of Armed Police Forces, Institute of Dizziness, General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, China.

To investigate the efficacy of semicircular canal occlusion in the treatment of intractable Ménière's disease in stage 3 or 4.Retrospective analysis of clincal date of twenty-nine patients who were referred to our institute and diagonsed with Ménière's disease. According to the preoperative staging of hearing, there were 12 cases in stage 3 and 17 cases in stage 4, and all patients underwent semicircular canal occlusion. Read More

Am J Otolaryngol 2017 May - Jun;38(3):285-290. Epub 2017 Jan 20.

Ear, Nose, and Throat Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Objectives: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration.

Study Design: Retrospective case series and patient survey.

Setting: Tertiary university hospital. Read More

Otol Neurotol 2017 04;38(4):547-550

*Department of Otolaryngology, The Ohio State University Wexner Medical Center, Ohio †Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Objectives: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops.

Patients: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jan;52(1):25-30

Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Eey and Ear Infirmary, Shandong Provincial Hospital Group, Shandong Provincial Key Laboratory of Hearing Reconstruction, Ji'nan 250021, China.

To evaluate the feasibility of combining simultaneous triple semicircular canal plugging (TSCP) and cochlear implantation (CI) to treat vertigo and hearing loss in advanced Meniere's disease(MD) patients, so as to provide an alternative surgical procedure for treating this disorder. Data from seven patients, who were referred to our hospital and diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006), from Jan. 2015 to Jan. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jan;31(2):127-129

Department of Otorhinolaryngology Head and Neck Surgery, Navy General Hospital.

To introduce and discuss a surgical technique, i.e. lateral and posterior semicircular canal plugging with endolymphatic sac decompression, to treat intractable Meniere's disease. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2017 Dec 3;134(6):441-444. Epub 2017 Jan 3.

Inserm UMR 1107, service ORL, laboratoire de biophysique neurosensorielle, université d'Auvergne, CHU Gabriel-Montpied, Clermont-Ferrand, France. Electronic address:

Objectives: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou: SFORL) for diagnostic and therapeutic strategy in Menière's disease.

Methods: A work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, then read over by an editorial group independent of the work group. Read More

J Int Adv Otol 2016 Dec;12(3):310-315

Division of Otolaryngology-Head-Neck Surgery, University of Montreal Hospital Centre (CHUM), Montreal, QC, Canada.

Objective: Endolymphatic sac decompression (ESD) for the treatment of Ménière's disease (MD) has had limited success and variable results in the literature. We have devised a novel technique that involves blocking the endolymphatic duct with surgical clips. In a separate effort to study the endolymphatic sac (ELS), we have sectioned the lateral part of the main body of the ELS as biopsies from a subset of patients. Read More

J Laryngol Otol 2017 Feb 15;131(2):144-149. Epub 2016 Dec 15.

Otorhinolaryngology Department,Faculty of Medicine,Hospital das Clínicas,University of São Paulo,Brazil.

Objective: To describe the results obtained with endolymphatic sac drainage in patients with Ménière's disease.

Method: A retrospective case review study was conducted of 95 Ménière's disease patients who underwent endolymphatic sac drainage in a tertiary care referral centre, after failing a long course of medical management. The main outcome measures were vertigo control and hearing preservation. Read More

Otol Neurotol 2017 02;38(2):192-198

*RPA Institute of Academic Surgery †Healthy Hearing and Balance Care ‡Brian and Mind Research Institute §Vestibular Research Laboratory, School of Psychology, The University of Sydney ||St. Vincent's Hospital ¶Sydney Cochlear Implant Centre, Sydney, Australia.

Objective: To investigate outcomes of cochlear implantation (CI) in patients with Ménière's disease (MD) with and without surgical labyrinthectomy.

Study Design: Retrospective study.

Setting: Multiple tertiary referral centers. Read More

HNO 2016 Nov;64(11):790-796

Klinik für Hals-, Nasen- und Ohrenheilkunde, Unfallkrankenhaus Berlin, Warener Str. 7, 12683, Berlin, Deutschland.

Background: Dehiscence syndromes of the semicircular canals are a relatively new group of neurotological disorders. They have a variety of symptoms with hearing/balance involvement. Younger patients have clinically relevant symptoms in only about one third of cases. Read More

Laryngoscope 2017 02 12;127(2):470-475. Epub 2016 Aug 12.

Department of Otology Auditory Implants and Skull Base Surgery, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.

Objective: To evaluate the efficacy of portable Meniett low-pressure pulse generator (Medtronic Xomed, Jacksonville, FL) in Meniere disease.

Study Design: Randomized, double-blind, placebo-controlled, multicenter trial carried out in 17 academic medical centers.

Methods: One hundred twenty-nine adults presenting Meniere disease (American Academy of Otolaryngology-Head and Neck Surgery criteria) not controlled by conventional medical treatment were included. Read More

Acta Otolaryngol 2016 Dec 19;136(12):1230-1235. Epub 2016 Jul 19.

a Department of Otorhinolaryngology-Head and Neck Surgery , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , PR China.

Conclusions: TSCP, which can reduce vertiginous symptoms in patients with intractable MD, represents an effective therapy for this disorder.

Objective: To explore the long-term efficacy of triple semicircular canal plugging (TSCP) in the treatment of intractable Meniere's disease (MD).

Methods: Seventy-nine patients diagnosed with unilateral MD referred to a vertigo clinic of the hospital between December 2010 and December 2013 were included in this study for retrospective analysis. Read More

PLoS One 2016 30;11(6):e0158309. Epub 2016 Jun 30.

Department of Otolaryngology, Nara Medical University, Kashihara-city, Nara, Japan.

Unlabelled: Meniere's disease, a common inner ear condition, has an incidence of 15-50 per 100,000. Because mental/physical stress and subsequent increase in the stress hormone vasopressin supposedly trigger Meniere's disease, we set a pilot study to seek new therapeutic interventions, namely management of vasopressin secretion, to treat this disease. We enrolled 297 definite Meniere's patients from 2010 to 2012 in a randomized-controlled and open-label trial, assigning Group-I (control) traditional oral medication, Group-II abundant water intake, Group-III tympanic ventilation tubes and Group-IV sleeping in darkness. Read More

Otol Neurotol 2016 08;37(7):937-9

*Michigan Ear Institute, Wayne State University School of Medicine, and Providence Hospital and Medical Center †Department of Radiology, Providence Hospital and Medical Center, Farmington Hills, Michigan.

Objective: Labyrinthectomy is considered the "gold standard" in the treatment of intractable vertigo attacks because of Ménière's Disease (MD) but sacrifices all residual hearing. Interest in auditory rehabilitation has lead to cochlear implantation in some patients. Concern remains that the cochlear lumen may fill with tissue or bone after surgery. Read More

Otol Neurotol 2016 08;37(7):873-7

Healthy Hearing and Balance Care, Sydney, NSW, Australia.

Objective: To contribute to the understanding of hearing fluctuation in Ménière's disease (MD) by disseminating a case study of a cochlear implanted ear with ongoing fluctuation of electrode impedances with episodic tinnitus and no associated vestibular symptoms.

Study Design: Retrospective case review.

Setting: Tertiary referral audiology clinic. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Jan;30(1):12-4

Objective: To compare the vertigo controlling situation between the endolymphatic sac decompression(ELSD) and semicircular canal occlusion (SCO) in stage 4 Ménière disease.

Method: Fourteen patients who underwent endolymphatic sac decompression and 9 patients who underwent semicircular canal occlusion from 2009 to 2013 were followed. All patients has complete preoperative examination and postoperative follow-up. Read More

Nat Rev Dis Primers 2016 05 12;2:16028. Epub 2016 May 12.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Meniere's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiology of MD is multifactorial. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. Read More

Auris Nasus Larynx 2017 Feb 19;44(1):116-118. Epub 2016 Mar 19.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan.

To increase the accuracy of identification of the endolymphatic sac during endolymphatic sac drainage surgery, we focused on the intra-operative identification of the operculum as a structural marker of the endolymphatic sac and the vestibular aqueduct at the rugose portion. Then, we examined the relationship between identification of the operculum and surgical outcomes. We used 100 cases with intractable Meniere's disease who received endolymphatic sac drainage with local steroid administration, superior to traditional endolymphatic sac drainage surgery and non-surgical medical treatment. Read More

Laryngorhinootologie 2016 Dec 18;95(12):831-836. Epub 2016 Mar 18.

Due to the natural aging and the loosened CI-implantation criteria more formerly operated Meniere's patients will be supplied with a cochlear implant. However, it raises the question whether an implantation in a previously treated ear is promising. Based on 2 cases in which we have carried out a CI-implantation, one of them 10 years after transmastoidal labyrinthectomy, and based on the current literature we draw attention to problems and prospects of success. Read More

Eur Arch Otorhinolaryngol 2016 Oct 8;273(10):2965-73. Epub 2016 Jan 8.

Division of Otolaryngology, Head and Neck Surgery, Montreal University Hospital Center (CHUM), University of Montreal, 1560, rue Sherbrooke East, Montreal, QC, H2L 4M1, Canada.

The aim of this study is to evaluate the quality of life (QOL) of patients treated by endolymphatic duct blockage (EDB) for Ménière's disease with a dedicated questionnaire. This is a retrospective cross-sectional study which included 54 patients diagnosed with severe, refractory Ménière's disease according to the AAO-HNS criteria and treated with EDB between 2010 and 2013. Answers to the first 38 questions have assigned scores from 0 to 4 (0 corresponding to the poorest QOL). Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Sep;50(9):733-7

Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China; Email:

Objective: To explore the long-term efficacy and safety of triple semicircular canal occlusion (TSCO) in the treatment of intractable Meniere's disease (MD) so as to provide an alternative surgical procedure for treating this disorder.

Methods: Data from Forty-nine patients, who were referred to our hospital and diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006) from Dec. 2010 to Jul. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Sep;50(9):729-32

Email:

Objective: To investigate the effect and mechanism of endolymphatic sac-mastoid shunt surgery for intractable Meniere's disease of different stages according to hearing level.

Methods: Data from 240 patients diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006) from January 1983 to January 2012 were analyzed in this study. Endolymphatic sac-mastoid shunt surgery was performed in affected ear for each patient. Read More

J Laryngol Otol 2016 Feb 17;130(2):204-6. Epub 2015 Dec 17.

Sir Charles Gairdner Hospital,Perth,Australia.

Background: Patients with Ménière's disease can develop unaidable sensorineural hearing loss. Cochlear implantation has recently been utilised in this group with favourable results. A more challenging group are those with intractable vertigo, and they have traditionally posed a significant management dilemma. Read More

Singapore Med J 2015 Nov;56(11):593-8

Mount Elizabeth Medical Centre, Singapore.

This paper aims to identify emerging evidence for endolymphatic sac surgery (ESS) in the treatment of Meniere's disease since the landmark study by Thomsen et al, published in 1998 (conducted from 1981 to 1989). Using the MEDLINE database (PubMed), a systematic review of the literature published from January 1990 to June 2014 was performed. We included all English-language, peer-reviewed randomised controlled trials (RCTs) and controlled studies. Read More

Auris Nasus Larynx 2016 Jun;43(3):287-91

Department of Otolaryngology - Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

Objectives: Mental disorder is often one of the causes to make treatments for Ménière's disease more difficult. The aim in the present study is to examine ratios of the neurosis and depression in patients with intractable Ménière's disease and also relationships between the ratios and surgical results after endolymphatic sac drainage with large doses of steroids.

Methods: Between 1998 and 2009, we enrolled 263 intractable Ménière's patients and divided into two groups, 207 in surgical group and 56 in non-surgical group. Read More

Biomed Res Int 2015 24;2015:457318. Epub 2015 Aug 24.

Department of Otolaryngology, Head and Neck Surgery, Unfallkrankenhaus Berlin, 12683 Berlin, Germany.

Objective. To investigate the treatment outcome of a simultaneous labyrinthectomy and cochlear implantation in patients with single-sided Ménière's disease and profound sensorineural hearing loss. Study Design. Read More

Otol Neurotol 2015 Sep;36(8):1328-30

ENT Department, St. Vincent's Public Hospital, Darlinghurst, Sydney, New South Wales, Australia.

Objectives: The aim of this study was to determine the prevalence of cochlear obliteration after labyrinthectomy.

Study Design: Retrospective review of medical records.

Setting: Tertiary referral center. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Feb;29(4):295-7

Objective: To investigate the effecacy of cochlear implantation (CI) improving hearing of Lermoyez's syndrome, we retrospectively analyzed a case of Lermoyez's syndrome whose left ear was extremely severe sensorineural deafness and right ear was severe sensorineural deafness.

Method: The patient had completed preoperative audiological examination , vestibular function and imaging examination, then was carried out bilateral endolymphatic sac decompression and left side CI. Follow up after the surgery. Read More

J Laryngol Otol 2015 Jul 26;129 Suppl 3:S58-60. Epub 2015 Mar 26.

Department of Otolaryngology,Prince of Wales Hospital and Sydney Children's Hospital,New South Wales,Australia.

Background: A dilemma occurs in the treatment of second-sided Ménière's disease in the only hearing ear, particularly in patients with severe symptoms such as 'drop attacks'. This paper describes a patient treated with contralateral cochlear implantation prior to vestibular nerve section of the symptomatic ear.

Case Report: A 53-year-old man, with second-sided Ménière's disease and drop attacks in the only serviceable right ear, underwent successful left cochlear implantation 30 years after hearing loss, followed by right vestibular nerve section. Read More

Acta Otolaryngol 2015 Jul 11;135(7):667-72. Epub 2015 Mar 11.

Department of Otolaryngology - Head and Neck Surgery, Nara Medical University , Nara , Japan.

Conclusions: At the second postoperative year, there were no significant differences between results for vertigo and hearing after endolymphatic sac drainage with steroid instillation surgery (EDSS) and EDSS with posterior tympanotomy with steroids at the round window (EDRW). In particular, as regards hearing recovery to the preoperative level, the periods after EDRW were shorter than those after the second EDSS.

Objectives: Patients sometimes faces recurrent problems years after EDSS due to endolymphatic sac closure and/or disease progression. Read More

Cochrane Database Syst Rev 2015 Mar 10(3):CD008419. Epub 2015 Mar 10.

ENT Surgery, Gelre Hospitals, Apeldoorn, Netherlands.

Background: Ménière's disease is an incapacitating disease in which recurrent attacks of vertigo are accompanied by hearing loss, tinnitus and/or aural fullness, all of which are discontinuous and variable in intensity. A number of different therapies have been identified for patients with this disease, ranging from dietary measures (e.g. Read More

J Neurophysiol 2015 Jun 4;113(10):3866-92. Epub 2015 Feb 4.

Department of Otolaryngology-HNS, University of Washington, Seattle, Washington; Department of Bioengineering, University of Washington, Seattle, Washington; National Primate Research Center, University of Washington, Seattle, Washington; and Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington.

Animal experiments and limited data in humans suggest that electrical stimulation of the vestibular end organs could be used to treat loss of vestibular function. In this paper we demonstrate that canal-specific two-dimensionally (2D) measured eye velocities are elicited from intermittent brief 2 s biphasic pulse electrical stimulation in four human subjects implanted with a vestibular prosthesis. The 2D measured direction of the slow phase eye movements changed with the canal stimulated. Read More

J Laryngol Otol 2015 Feb 30;129(2):120-5. Epub 2015 Jan 30.

Department of Otolaryngology,Tokyo Medical University,Japan.

Objective: To evaluate the effectiveness of tympanostomy tube placement in controlling symptoms of intractable Ménière's disease.

Methods: Fifteen patients with intractable Ménière's disease underwent tympanostomy tube placement in the affected ear. Post-operative changes in vertigo attacks and hearing level were recorded, and were evaluated according to American Academy of Otolaryngology-Head and Neck Surgery criteria. Read More

Cochlear Implants Int 2015 Jul 9;16(4):208-12. Epub 2014 Dec 9.

Objectives: Few studies have addressed the benefits of cochlear implantation for the small group of patients with bilateral, end-stage Meniere's disease, or unilateral disease with contralateral hearing loss from another cause. Our retrospective study evaluates the effectiveness and post-operative performance in these Meniere's disease patients and discusses these findings relative to other post-lingually deafened adults.

Methods: Among 456 adults who received cochlear implants, we identified eight (1. Read More

Eur Arch Otorhinolaryngol 2015 Dec 7;272(12):3645-50. Epub 2014 Dec 7.

Otology and Skull Base Surgery Unit, Siena University Hospital, Siena, Italy.

This study aims to compare the outcomes of patients with Meniere's disease submitted to either endolymphatic mastoid shunt (ES) or tenotomy of the stapedius and tensor tympani muscles (TSTM). This is a retrospective chart review of patients treated with ES or TSTM between 2000 and 2010 and followed up for at least 12 months. The main outcomes were represented by: (1) vertigo class, hearing stage and functional level according to the American Academy of Otolaryngology-Head and Neck Surgery criteria; (2) adjustment of dizziness handicap inventory (DHI) and (3) complete and substantial vertigo control using the Kaplan-Meier survival method. Read More

Otolaryngol Head Neck Surg 2015 Jan 17;152(1):122-9. Epub 2014 Nov 17.

Department of Statistics, University of Montreal, Montreal, Quebec, Canada.

Objectives: To compare the effectiveness of the endolymphatic duct blockage (EDB) and the endolymphatic sac decompression (ESD) to control Ménière's disease symptoms and to evaluate their effect on hearing level.

Study Design: Prospective nonblinded randomized study.

Setting: Tertiary medical center. Read More

BMJ 2014 Nov 12;349:g6544. Epub 2014 Nov 12.

Imperial College London, London, UK.

Acta Otolaryngol 2014 Oct 18;134(10):990-1004. Epub 2014 Aug 18.

Department of Otolaryngology, Hiroshima University Faculty of Medicine , Hiroshima , Japan.

Conclusion: A new murine model of Ménière's disease has been developed, based on long-term administration of vasopressin. Induction of vestibular dysfunction in the present animal model can cause additional stress, by reducing inner ear blood flow. Latanoprost, a selective agonist for the FP prostanoid receptor, may become a new remedy for Ménière's disease. Read More

Srp Arh Celok Lek 2014 May-Jun;142(5-6):291-5

Introduction: Over the last two decades the intratympanic perfusion of corticosteroids has been used as a minimally invasive surgical therapy of Meniere's disease. According to experimental studies the antiinflammatory, immunoprotective, antioxidant and neuroprotective role of the locally perfused corticosteroids was noticed in the inner ear structures. The recovery of action potentials in the cells of the Corti organ was confirmed as well as a decreased expression of aquaporine-1, a glycoprotein responsible for labyrinth hydrops and N and K ions derangement. Read More