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Orv Hetil 2020 Feb;161(5):177-182

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szigony u 36., 1083.

Tenotomy of the tendon of the stapedius and tensor tympani (TT) muscles is a minimal-invasive surgical therapeutic procedure in Ménière's disease (MD). It has been assumed that the TT medializes the stapes into the oval window, resulting in changes in perilymphatic pressures of the inner ear. By cutting the tendons of both middle ear muscles, they affect the pressure dynamics by not augmenting this pressure even further. Read More

Braz J Otorhinolaryngol 2019 Nov - Dec;85(6):788-798. Epub 2019 Sep 20.

Universidade de Brasília (UnB), Faculdade de Ciências de Saúde, Programa de Pós-Graduação em Ciências da Saúde, Brasília, DF, Brazil; Faculdade de Ciências de Saúde ‒ Asa Norte, Brasília, DF, Brazil; Hospital Universitário de Brasília, Brasília, DF, Brazil. Electronic address:

Introduction: People with vestibular loss present a deficit in the vestibular system, which is primarily responsible for promoting postural control, gaze stabilization, and spatial orientation while the head moves. There is no effective treatment for a bilateral loss of vestibular function. Recently, a vestibular implant was developed for people with bilateral loss of vestibular function to improve this function and, consequently, the quality of life of these patients. Read More

Clin Neurophysiol 2019 09 31;130(9):1539-1556. Epub 2019 May 31.

Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland.

Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs respectively) are now used by an increasing number of laboratories to evaluate otolith inner ear function and their pathways through the central nervous system. However, the literature is incomplete or unclear as to what information both c- and oVEMPs can add beyond what a good clinical examination can provide, and what other paramedical tests can provide also, and the present review aims to clarify what is known so far. The following review will describe what is known with regards to both c- and oVEMPs and their use. Read More

Acta Otolaryngol 2019 Sep 5;139(9):739-746. Epub 2019 Jul 5.

a Department of Otolaryngology - Head and Neck Surgery, Nara Medical University , Kashihara , Japan.

Endolymphatic sac drainage (ELSD) may have a positive effect on endolymphatic hydrops (EH) and may help to preserve inner ear function. However, the relationship between changes in EH volumes and hearing function after ELSD has not been described. We aimed to reveal the factors related to changes in hearing and EH following ELSD. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jun;33(6):501-504

Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine.

To compare functional outcomes after different surgical procedures in treatment of patients with Meniere's disease. Patients with Meniere's disease were categorized into different groups mainly based on pure-tone average and functional level scale. Individualized surgical procedure was provided including endolymphatic sac shunt or decompression (ELSS), vestibular neurectomy (VN), labyrinthectomy (LC), semicircular canals plugging (SCP) and endolymphatic duct blockage (EDB). Read More

J Int Adv Otol 2019 Apr;15(1):121-129

Department of Neurology, Hubei University of Medicine, Taihe Hospital, Shiyan, China.

Objectives: This study aimed to assess the clinical benefit of device therapy on controlling the symptoms of Meniere's disease (MD).

Materials And Methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Internet, and Wanfang Data before January 13, 2018. We selected randomized controlled clinical trials, case-controlled studies, and cohort studies that dealt with outcomes of device therapy for the treatment of MD. Read More

Eur Arch Otorhinolaryngol 2019 Jul 11;276(7):1943-1950. Epub 2019 Apr 11.

UOSD "Vestibologia E Otorinolaringoiatria" Presidio Ospedaliero "Giovanni Paolo II", Policoro, Italy.

Purpose: Ménière's disease (MD) is an inner ear disorder of unknown etiology, whose pathological substrate is the endolymphatic hydrops. Different treatments have been proposed; however, evidence of their effectiveness is lacking. The aim of this study was to evaluate by a questionnaire which medical and surgical treatments are used in Italy for the treatment of MD and to compare them with those proposed in other countries. Read More

Eur Arch Otorhinolaryngol 2019 Jun 30;276(6):1617-1624. Epub 2019 Mar 30.

Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan.

Purpose: Identification of the endolymphatic sac has failed occasionally. Postoperative complications have also rarely been reported. Given a safer and more reliable surgery, preoperative anatomical assessments are valuable, however, the vestibular aqueduct has seldom been seen with multi-planar reconstruction (MPR) computed tomography (CT) images yet. Read More

Auris Nasus Larynx 2019 Jun 27;46(3):335-345. Epub 2018 Nov 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This study was performed to determine whether endolymphatic sac surgery improves vestibular and cochlear endolymphatic hydrops 2 years after sac surgery and to elucidate the relationship between the degree of improvement of endolymphatic hydrops and the changes in vertigo symptoms, the hearing level, and the summating potential/action potential ratio (-SP/AP ratio) by electrocochleography (ECochG) in patients with Ménière's disease (MD).

Methods: Twenty-one patients with unilateral MD who underwent sac surgery were included in this study. All patients underwent gadolinium-enhanced magnetic resonance imaging (Gd-MRI) before and 2 years after sac surgery. Read More

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

Wien Klin Wochenschr 2019 Feb 12;131(3-4):87-91. Epub 2018 Nov 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung Teaching Hospital, Juchgasse 25, 1030, Vienna, Austria.

Tenotomy of the tendon of the stapedius and tensor tympani muscles is a relatively unknown therapeutic procedure in Menière's disease. Widespread approaches include medicinal treatment with betahistine or diuretics as well as interventional procedures, such as intratympanic gentamicin or glucocorticoid injection, vestibular neurectomy, labyrinthectomy or endolymphatic sac surgery. The exact pathomechanism of this approach is not fully known. Read More

J Int Adv Otol 2018 Aug;14(2):334-336

Department of Otorhinolaryngology, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain.

Different types of otic capsule dehiscence restricted to the cochlea have been described. Here we describe the case of a patient with a cochlear-internal auditory canal dehiscence associated with a cochlear-facial dehiscence not reported before. A 53-year-old patient with severe to profound sensorineural hearing loss due to bilateral Meniere's disease underwent a cochlear implant surgery on the right ear. Read More

J Int Adv Otol 2018 Aug;14(2):317-321

Universita degli Studi di Siena, Siena, Italy.

Meniere Disease keeps challenges in its diagnosis and treatment since was defined by Prosper Meniere at the beginning of 19th Century. Several classifications and definition were made until now and speculations still exist on its etiology. As the etiology remains speculative the treatment models remain in discussion also. Read More

Audiol Neurootol 2018 31;23(2):98-104. Epub 2018 Aug 31.

Background: Patients with a superior canal dehiscence syndrome display symptoms of the vestibular disorder except that of hearing loss. Therefore, any type of surgery should treat those symptoms without affecting the hearing threshold. The aim of this study was to evaluate the extent to which the hearing threshold has been affected; the evaluation process was carried out by a transmastoid plugging of the superior canal. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):662-667

Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital, Beijing 100123, China.

Objective: To investigate the postoperative anxiety and its relationship with life quality in patients with Ménière's diseases.
 Methods: A total of 68 patients with Ménière's disease, who received the treatment of endolymphatic sac decompression from 2010 to 2016, were enrolled. They finished two scales (the self-rating anxiety scale and the quality of life questionnaire for endolymphatic sac decompression of Ménière's disease) by snail mail. Read More

Am J Otolaryngol 2018 Nov - Dec;39(6):731-736. Epub 2018 Aug 1.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; University of Massachusetts Medical School, Worcester, MA, USA; Department of Otolaryngology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA, USA. Electronic address:

Purpose: Effective operative approaches for the treatment of refractory vertigo in Meniere's disease are invasive. Vestibular neurectomy can preserve hearing and has been shown to be effective; however, current approaches require an extensive craniotomy. Transcanal endoscopic approaches to the internal auditory canal (IAC) with cochlear preservation have been recently described and may offer a minimally invasive approach to selectively sectioning the distal vestibular nerves while preserving residual hearing. Read More

Acta Otolaryngol 2018 Oct 17;138(10):886-892. Epub 2018 Jul 17.

b Department of Otolaryngology-Head & Neck Surgery , University of Montreal Hospital Centre Research Centre (CRCHUM) , Montreal , Canada.

Background: Endolymphatic sac decompression has shown limited success for the treatment of Ménière's disease (MD). We have published a novel technique with very promising results for the treatment of refractory MD: the Endolymphatic Duct Blockage (EDB) with two titanium clips. One of the challenges of this technique was an increased incidence of intraoperative Cerebrospinal Fluid (CSF) Leak. Read More

J Int Adv Otol 2018 Apr;14(1):18-21

Department of Otorhinolaryngology, University of Navarra Clinic, Pamplona/Navarra, Spain.

Objectives: To measure the auditory (pure tone audiometry and word recognition scores) and vestibular (video head impulse test and vestibular myogenic potentials) outcomes in patients diagnosed with Meniere's disease (MD) who underwent cochlear implantation.

Material And Methods: This prospective study included 23 cochlear implant users with MD and 29 patients diagnosed with far-advanced otosclerosis (the control group).

Results: The preoperative mean pure tone average thresholds were 99 and 122. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):138-142

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education Beijing,100730,China.

To investigate the long-term efficacy of endolymphatic sac mastoid drainage for Ménière disease.Data from 26 patients diagnosed with MD strictly meeting the criteria issued by " Guideline of diagnosis and treatment of Meniere disease(2017)" from 2006 to 2015 were analyzed in this study.Endolymphatic sac mastoid shunt surgery was performed for each patient. Read More

Otol Neurotol 2018 06;39(5):616-621

Wayne State University, Detroit.

Objective: Endolymphatic sac decompression surgery (ELSD) may be used to treat patients who have Menière's 's disease refractory to medical therapy. In this study, we investigated whether or not the injection of steroid into the endolymphatic sac at the time of ELSD provides additional benefit to patient outcomes.

Study Design: Randomized prospective single-blinded placebo-controlled study. Read More

Acta Otolaryngol 2018 Mar;138(3):304-309

Otolaryngol Head Neck Surg 2018 04 13;158(4):721-728. Epub 2018 Feb 13.

1 University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, QC, Canada.

Objectives Endolymphatic sac (ELS) pathophysiology in Ménière's disease (MD) remains poorly understood. We identified from the literature a group of proteins expressed on the ELS and involved in endolymph volume regulation: aquaporin-2 (AQP2), vasopressin receptor V2R, sodium potassium chloride cotransporter 2 (NKCC2), and transient receptor potential cation channel V4 (TRPV4). Our objective was to determine whether their ELS expression was altered in MD, to better understand the pathophysiology of endolymphatic hydrops. Read More

J Multidiscip Healthc 2018 22;11:1-11. Epub 2017 Dec 22.

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. Read More

Clin Otolaryngol 2018 06 25;43(3):920-923. Epub 2018 Mar 25.

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Otol Neurotol 2017 12;38(10):1484-1489

*Department of Otolaryngology-Head and Neck Surgery †Department of General Surgery, Detroit Medical Center, Michigan State University, Detroit ‡Department of Radiology, Michigan State University, East Lansing §Department of Otology, Neurotology, and Skull Base Surgery, Michigan Ear Institute, Farmington Hills, Michigan.

Objective: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls.

Study Design: Retrospective chart review.

Setting: Two tertiary referral centers. Read More

Auris Nasus Larynx 2018 Jun 31;45(3):427-432. Epub 2017 Jul 31.

Department of Otolaryngology, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Objective: To evaluate the histopathologic changes in tympanic membranes (TMs) with ventilation tubes (VTs).

Methods: In this retrospective human temporal bone study our overall study group included 4 subgroups of TMs from deceased donors as follows: 24 with a history of VT insertion for chronic otitis media with effusion (COME-VT); 5 with a history of VT insertion for Meniere's disease (MD-VT); 33 without a history of VT insertion for chronic otitis media with effusion (COME); and 14 without a history of VT insertion for Meniere's disease (MD). We classified the extent of migration of the outer keratinized squamous epithelium onto the inner surface of TM perforations and noted the presence and location of tympanosclerosis, of atrophy, of perforation, and/or of cholesteatoma formation. Read More

Auris Nasus Larynx 2018 Jun 29;45(3):393-398. Epub 2017 Jul 29.

Department of Otolaryngology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, Japan. Electronic address:

Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. Read More

Neurol Sci 2017 May;38(Suppl 1):193-196

Department of Neurosciences, Reproductive Sciences and Odontostomatology, Headache Centre, University of Naples "Federico II", Via Pansini, 5, 80131, Naples, Italy.

Idiopathic intracranial hypertension is characterized by raised intracranial pressure (ICP) without any underlying pathology, presenting with (IIH) or without papilledema (IIHWOP). Headache, often on daily basis, is the most frequent symptom. Among audiovestibular symptoms, tinnitus and dizziness are commonly reported, while vertigo and hearing impairment are infrequent reports. Read More

Laryngorhinootologie 2017 Apr 12;96(S 01):S209-S229. Epub 2017 May 12.

Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum am St. Elisabeth-Hospital Bochum.

Vertigo is not a well defined symptom but a heterogenous entity diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine and primary care physicians. Most vertigo syndroms have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe the development of surgical therapy for hydropic inner ear diseases, Menière disease, dehiscence syndroms, perilymphatic fistulas, and benign paroxysmal vertigo. Read More

Int Arch Otorhinolaryngol 2017 Apr;21(2):179-183

Otorhinolaryngology and Neurotology, Grupo Otológico Médica Sur, Neurociencias Clínicas e Investigación, Ciudad de México, DF, Mexico.

 The endolymphatic sac is thought to maintain the hydrostatic pressure and endolymph homeostasis for the inner ear, and its dysfunction may contribute to the pathophysiology of Ménière's disease. Throughout the years, different surgical procedures for intractable vertigo secondary to Ménière's disease have been described, and though many authors consider these procedures as effective, there are some who question its long-term efficacy and even those who think that vertigo control is achieved more due to a placebo effect than because of the procedure itself.  To review the different surgical procedures performed in the endolymphatic sac for the treatment of Ménière's disease. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;31(4):272-276

Department of Otolaryngology Head and Neck Surgery, General Hospital of Armed Police Forces, Institute of Dizziness, General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, China.

To investigate the efficacy of semicircular canal occlusion in the treatment of intractable Ménière's disease in stage 3 or 4.Retrospective analysis of clincal date of twenty-nine patients who were referred to our institute and diagonsed with Ménière's disease. According to the preoperative staging of hearing, there were 12 cases in stage 3 and 17 cases in stage 4, and all patients underwent semicircular canal occlusion. Read More

Am J Otolaryngol 2017 May - Jun;38(3):285-290. Epub 2017 Jan 20.

Ear, Nose, and Throat Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Objectives: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration.

Study Design: Retrospective case series and patient survey.

Setting: Tertiary university hospital. Read More

Otol Neurotol 2017 04;38(4):547-550

*Department of Otolaryngology, The Ohio State University Wexner Medical Center, Ohio †Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Objectives: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops.

Patients: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jan;52(1):25-30

Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Eey and Ear Infirmary, Shandong Provincial Hospital Group, Shandong Provincial Key Laboratory of Hearing Reconstruction, Ji'nan 250021, China.

To evaluate the feasibility of combining simultaneous triple semicircular canal plugging (TSCP) and cochlear implantation (CI) to treat vertigo and hearing loss in advanced Meniere's disease(MD) patients, so as to provide an alternative surgical procedure for treating this disorder. Data from seven patients, who were referred to our hospital and diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006), from Jan. 2015 to Jan. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jan;31(2):127-129

Department of Otorhinolaryngology Head and Neck Surgery, Navy General Hospital.

To introduce and discuss a surgical technique, i.e. lateral and posterior semicircular canal plugging with endolymphatic sac decompression, to treat intractable Meniere's disease. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2017 Dec 3;134(6):441-444. Epub 2017 Jan 3.

Inserm UMR 1107, service ORL, laboratoire de biophysique neurosensorielle, université d'Auvergne, CHU Gabriel-Montpied, Clermont-Ferrand, France. Electronic address:

Objectives: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou: SFORL) for diagnostic and therapeutic strategy in Menière's disease.

Methods: A work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, then read over by an editorial group independent of the work group. Read More

J Int Adv Otol 2016 Dec;12(3):310-315

Division of Otolaryngology-Head-Neck Surgery, University of Montreal Hospital Centre (CHUM), Montreal, QC, Canada.

Objective: Endolymphatic sac decompression (ESD) for the treatment of Ménière's disease (MD) has had limited success and variable results in the literature. We have devised a novel technique that involves blocking the endolymphatic duct with surgical clips. In a separate effort to study the endolymphatic sac (ELS), we have sectioned the lateral part of the main body of the ELS as biopsies from a subset of patients. Read More

J Laryngol Otol 2017 Feb 15;131(2):144-149. Epub 2016 Dec 15.

Otorhinolaryngology Department,Faculty of Medicine,Hospital das Clínicas,University of São Paulo,Brazil.

Objective: To describe the results obtained with endolymphatic sac drainage in patients with Ménière's disease.

Method: A retrospective case review study was conducted of 95 Ménière's disease patients who underwent endolymphatic sac drainage in a tertiary care referral centre, after failing a long course of medical management. The main outcome measures were vertigo control and hearing preservation. Read More

Otol Neurotol 2017 02;38(2):192-198

*RPA Institute of Academic Surgery †Healthy Hearing and Balance Care ‡Brian and Mind Research Institute §Vestibular Research Laboratory, School of Psychology, The University of Sydney ||St. Vincent's Hospital ¶Sydney Cochlear Implant Centre, Sydney, Australia.

Objective: To investigate outcomes of cochlear implantation (CI) in patients with Ménière's disease (MD) with and without surgical labyrinthectomy.

Study Design: Retrospective study.

Setting: Multiple tertiary referral centers. Read More

HNO 2016 Nov;64(11):790-796

Klinik für Hals-, Nasen- und Ohrenheilkunde, Unfallkrankenhaus Berlin, Warener Str. 7, 12683, Berlin, Deutschland.

Background: Dehiscence syndromes of the semicircular canals are a relatively new group of neurotological disorders. They have a variety of symptoms with hearing/balance involvement. Younger patients have clinically relevant symptoms in only about one third of cases. Read More

Laryngoscope 2017 02 12;127(2):470-475. Epub 2016 Aug 12.

Department of Otology Auditory Implants and Skull Base Surgery, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.

Objective: To evaluate the efficacy of portable Meniett low-pressure pulse generator (Medtronic Xomed, Jacksonville, FL) in Meniere disease.

Study Design: Randomized, double-blind, placebo-controlled, multicenter trial carried out in 17 academic medical centers.

Methods: One hundred twenty-nine adults presenting Meniere disease (American Academy of Otolaryngology-Head and Neck Surgery criteria) not controlled by conventional medical treatment were included. Read More

Acta Otolaryngol 2016 Dec 19;136(12):1230-1235. Epub 2016 Jul 19.

a Department of Otorhinolaryngology-Head and Neck Surgery , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , PR China.

Conclusions: TSCP, which can reduce vertiginous symptoms in patients with intractable MD, represents an effective therapy for this disorder.

Objective: To explore the long-term efficacy of triple semicircular canal plugging (TSCP) in the treatment of intractable Meniere's disease (MD).

Methods: Seventy-nine patients diagnosed with unilateral MD referred to a vertigo clinic of the hospital between December 2010 and December 2013 were included in this study for retrospective analysis. Read More

PLoS One 2016 30;11(6):e0158309. Epub 2016 Jun 30.

Department of Otolaryngology, Nara Medical University, Kashihara-city, Nara, Japan.

Unlabelled: Meniere's disease, a common inner ear condition, has an incidence of 15-50 per 100,000. Because mental/physical stress and subsequent increase in the stress hormone vasopressin supposedly trigger Meniere's disease, we set a pilot study to seek new therapeutic interventions, namely management of vasopressin secretion, to treat this disease. We enrolled 297 definite Meniere's patients from 2010 to 2012 in a randomized-controlled and open-label trial, assigning Group-I (control) traditional oral medication, Group-II abundant water intake, Group-III tympanic ventilation tubes and Group-IV sleeping in darkness. Read More

Otol Neurotol 2016 08;37(7):937-9

*Michigan Ear Institute, Wayne State University School of Medicine, and Providence Hospital and Medical Center †Department of Radiology, Providence Hospital and Medical Center, Farmington Hills, Michigan.

Objective: Labyrinthectomy is considered the "gold standard" in the treatment of intractable vertigo attacks because of Ménière's Disease (MD) but sacrifices all residual hearing. Interest in auditory rehabilitation has lead to cochlear implantation in some patients. Concern remains that the cochlear lumen may fill with tissue or bone after surgery. Read More

Otol Neurotol 2016 08;37(7):873-7

Healthy Hearing and Balance Care, Sydney, NSW, Australia.

Objective: To contribute to the understanding of hearing fluctuation in Ménière's disease (MD) by disseminating a case study of a cochlear implanted ear with ongoing fluctuation of electrode impedances with episodic tinnitus and no associated vestibular symptoms.

Study Design: Retrospective case review.

Setting: Tertiary referral audiology clinic. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Jan;30(1):12-4

Objective: To compare the vertigo controlling situation between the endolymphatic sac decompression(ELSD) and semicircular canal occlusion (SCO) in stage 4 Ménière disease.

Method: Fourteen patients who underwent endolymphatic sac decompression and 9 patients who underwent semicircular canal occlusion from 2009 to 2013 were followed. All patients has complete preoperative examination and postoperative follow-up. Read More

Nat Rev Dis Primers 2016 05 12;2:16028. Epub 2016 May 12.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Meniere's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiology of MD is multifactorial. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. Read More

Auris Nasus Larynx 2017 Feb 19;44(1):116-118. Epub 2016 Mar 19.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan.

To increase the accuracy of identification of the endolymphatic sac during endolymphatic sac drainage surgery, we focused on the intra-operative identification of the operculum as a structural marker of the endolymphatic sac and the vestibular aqueduct at the rugose portion. Then, we examined the relationship between identification of the operculum and surgical outcomes. We used 100 cases with intractable Meniere's disease who received endolymphatic sac drainage with local steroid administration, superior to traditional endolymphatic sac drainage surgery and non-surgical medical treatment. Read More

Laryngorhinootologie 2016 Dec 18;95(12):831-836. Epub 2016 Mar 18.

Due to the natural aging and the loosened CI-implantation criteria more formerly operated Meniere's patients will be supplied with a cochlear implant. However, it raises the question whether an implantation in a previously treated ear is promising. Based on 2 cases in which we have carried out a CI-implantation, one of them 10 years after transmastoidal labyrinthectomy, and based on the current literature we draw attention to problems and prospects of success. Read More

Eur Arch Otorhinolaryngol 2016 Oct 8;273(10):2965-73. Epub 2016 Jan 8.

Division of Otolaryngology, Head and Neck Surgery, Montreal University Hospital Center (CHUM), University of Montreal, 1560, rue Sherbrooke East, Montreal, QC, H2L 4M1, Canada.

The aim of this study is to evaluate the quality of life (QOL) of patients treated by endolymphatic duct blockage (EDB) for Ménière's disease with a dedicated questionnaire. This is a retrospective cross-sectional study which included 54 patients diagnosed with severe, refractory Ménière's disease according to the AAO-HNS criteria and treated with EDB between 2010 and 2013. Answers to the first 38 questions have assigned scores from 0 to 4 (0 corresponding to the poorest QOL). Read More