386 results match your criteria Inner Ear Meniere Disease Medical Treatment


Investigation of endolymphatic hydrops positivity rates in patients with recurrent audiovestibular symptoms using inner ear magnetic resonance imaging.

Auris Nasus Larynx 2021 Jun 17. Epub 2021 Jun 17.

Department of Otolaryngology, Takai Hospital, Nara, Japan.

Objectives: This study aimed to investigate the endolymphatic hydrops (EH)-positivity rates among patients with recurrent audiovestibular symptoms using intravenous injection of gadolinium-enhanced inner ear magnetic resonance imaging (ieMRI).

Methods: We reviewed 710 successive patients with recurrent audiovestibular symptoms at the Vertigo/Dizziness Center of Nara Medical University and other related hospitals, between May 2014 and April 2020. We performed ieMRI on 153 patients with unilateral recurrent cochleovestibular symptoms (rCV), 51 with recurrent vertigo symptoms (rVO), and 84 with unilateral recurrent cochlear symptoms (rCO). Read More

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First-in-human intracochlear application of human stromal cell-derived extracellular vesicles.

J Extracell Vesicles 2021 Jun 4;10(8):e12094. Epub 2021 Jun 4.

Department of Transfusion Medicine University Hospital Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU) Salzburg Austria.

Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti-inflammatory effects. MSC-EVs may serve as promising cell-based therapeutics for the inner ear to attenuate inflammation-based side effects from cochlear implantation which represents an unmet clinical need. In an individual treatment performed on a 'named patient basis', we intraoperatively applied allogeneic umbilical cord-derived MSC-EVs (UC-MSC-EVs) produced according to good manufacturing practice. Read More

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Magnetic resonance imaging of the inner ear in the diagnostics of Ménière's disease.

Otolaryngol Pol 2020 Dec;75(2):1-8

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD.

Ménière's disease is characterized by sudden episodes of vertigo accompanied by tinnitus and/or feeling of fullness in the ear as well as fluctuating sensorineural hearing loss. Despite numerous studies, the etiology of this disease remains unknown. However, the enlargement of the inner ear's endolymphatic spaces, referred to as endolymphatic hydrops, is considered the underlying condition. Read More

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December 2020

Correlation between magnetic resonance imaging classification of endolymphatic hydrops and clinical manifestations and audiovestibular test results in patients with definite Ménière's disease.

Auris Nasus Larynx 2021 Apr 14. Epub 2021 Apr 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland.

Objectives: The purpose was to evaluate magnetic resonance imaging (MRI) classification of endolymphatic hydrops with clinical features, audiological and vestibular tests in patients with definite unilateral Ménière's disease (MD).

Methods: Thirty-eight patients were enrolled in this study. The severity of the main clinical symptoms, audiovestibular tests, and MRI, performed 4 hours after intravenous injection of gadobutrol to visualize inner ear compartments, were evaluated. Read More

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Effectiveness of intratympanic dexamethasone for the treatment of vertigo attacks in patients with Ménière's disease compared with betahistine pharmacotherapy.

J Int Med Res 2021 Apr;49(4):300060520985647

37637Semmelweis University, Department of Otolaryngology and Head and Neck Surgery, Budapest, Hungary.

Objective: This study analyzed the possible effects of intratympanic steroid (ITS) therapy in the symptomatic treatment of vertigo attacks in patients with Ménière's disease.

Methods: Thirty-five patients treated with ITS (dexamethasone) plus betahistine (Group A) and 35 patients treated with betahistine alone (Group B) were enrolled in this investigation. Complaints were analyzed using medical records and vertigo diaries. Read More

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Comparison of inner ear MRI enhancement in patients with Meniere's disease after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Eur J Radiol 2021 Jun 26;139:109682. Epub 2021 Mar 26.

Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China. Electronic address:

Purpose: To compare the enhancement results of three gadolinium contrast agents in the inner ear of patients with Meniere's disease 4 h after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Methods: We enrolled 60 patients with a definitive diagnosis of unilateral Meniere's disease and divided them into three groups of 20 patients; each group received a double dose of gadobutrol, gadoterate meglumine, or gadodiamide. The postcontrast signal intensity of the basal cochlear turn was scored quantitatively, and qualitative visual evaluation of the cochlea, vestibule and semi-circular canals was also performed. Read More

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[Various types of vertigo and balance disorders in patients with Meniere's disease].

Vestn Otorinolaringol 2021 ;86(1):90-95

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Vertigo and balance disorders in Meniere's disease (MD) may have various etiology. The aim of the review is discussing pathogenetic mechanisms of the typical vertiginous paroxysms in MD, resulting from endolymphatic hydrops as well as analysis of etiology, pathogenesis, clinical course and basic treatment of paroxysmal and permanent forms of vertigo and balance disorders, caused by other conditions, associated with MD. We discussed the course of MD complicated by vestibular migraine, benign positional paroxysmal vertigo, functional dizziness, bilateral vestibulopathy and vestibular drop-attacks. Read More

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Effects of Glucocorticoids on the Inner Ear.

Front Surg 2020 11;7:596383. Epub 2021 Jan 11.

Department of Otorhinolaryngology Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.

Recently, several lines of evidence have suggested that the inner ear is under hormonal control. It is likely that steroids have some influence on the inner ear. Many clinicians have been empirically using steroids for the treatment of diseases associated with endolymphatic hydrops. Read More

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January 2021

Frequency-specific Electrocochleography and Traveling Wave Time as a Clinical Test for Menière's Disease.

Otol Neurotol 2021 02;42(2):290-293

Michigan Ear Institute, Farmington Hills, Michigan.

Introduction: Menière's disease is a clinical entity with no definitive objective testing. It has been hypothesized that underlying endolymphatic hydrops stiffens the basilar membrane leading to increased speed of the acoustic stimulus, therefore traveling wave velocity has been proposed as an objective test to aid in the diagnosis. The objective of this study is to compare electrocochleography frequency-specific action potential latency, basilar membrane traveling wave time, and summation to action potential (SP/AP) ratio in Menière's and non-Menière's patients. Read More

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February 2021

Meniere's disease: Medical management, rationale for vestibular preservation and suggested protocol in medical failure.

Am J Otolaryngol 2021 Jan - Feb;42(1):102817. Epub 2020 Nov 2.

House Ear Clinic, House Institute Foundation, United States of America. Electronic address:

Meniere's disease is a peripheral audiovestibular disorder characterized by vertigo, hearing loss, tinnitus, and aural fullness. Management of these symptoms includes medical and surgical treatment. Many patients with Meniere's disease can be managed using nonablative therapy, such as intratympanic steroids and endolymphatic shunt surgery, prior to ablative techniques such as intratympanic gentamicin. Read More

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Triple Canal Occlusion for the Treatment of Intractable Menière's Disease.

Otol Neurotol 2021 01;42(1):116-120

Department of Otolaryngology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Objective: Menière's disease can be a debilitating condition but in most cases the symptoms are controlled by lifestyle changes and medical management. However, some patients remain symptomatic despite medical treatment and have the option of more invasive surgical treatments. Surgical intervention for Menière's includes a range of interventions from grommet insertion, intratympanic steroids/Gentamicin, endolymphatic sac decompression, labyrinthectomy, and vestibular neurectomy. Read More

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January 2021

[Benign paroxysmal positional vertigo associated with trauma, middle and inner ear diseases].

Vestn Otorinolaringol 2020 ;85(5):12-17

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: The aim of the study is to compare clinical symptoms and treatment of posttraumatic benign paroxysmal positional vertigo (BPPV), BPPV associated with middle and inner ear diseases and idiopathic BPPV (iBPPV).

Patients And Methods: 640 patients with BPPV of various canals were enrolled in the study. 455 (71. Read More

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November 2020

[Efficacy of semicircular canal occlusion in the treatment of fifteen pateints with Meniere's disease].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Apr;34(4):337-339

Department of Otolaryngology Head and Neck Surgery,the Third Medical Center of PLA General Hospital,Beijing,100039,China.

To investigate the long-term efficacy of semicircular canal occlusion in the treatment of refractory Meniere's disease. Fifteen patients with Meniere's disease who underwent semicircular canal occlusion were reviewed. The preoperative and postoperative frequency of vertigo ,quality of life, hearing and tinnitus level were compared. Read More

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Transmastoid Labyrinthectomy for Menière's Disease: Experience and Outcomes.

Otol Neurotol 2020 12;41(10):1413-1418

Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School.

Objective: To characterize presurgical symptoms and treatment history and postoperative course in patients with medically recalcitrant Menière's disease undergoing transmastoid labyrinthectomy in the post-intratympanic gentamicin era.

Study Design: Retrospective case series.

Setting: Tertiary academic medical center. Read More

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December 2020

MicroRNA Profiling as a Methodology to Diagnose Ménière's Disease: Potential Application of Machine Learning.

Otolaryngol Head Neck Surg 2021 02 14;164(2):399-406. Epub 2020 Jul 14.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Kansas, Kansas City, Kansas, USA.

Objective: Diagnosis and treatment of Ménière's disease remains a significant challenge because of our inability to understand what is occurring on a molecular level. MicroRNA (miRNA) perilymph profiling is a safe methodology and may serve as a "liquid biopsy" equivalent. We used machine learning (ML) to evaluate miRNA expression profiles of various inner ear pathologies to predict diagnosis of Ménière's disease. Read More

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February 2021

Assessment of the Progression of Vertical Semicircular Canal Dysfunction and Increased Vestibular Endolymphatic Hydrops in Patients With Early-Stage Ménière Disease.

JAMA Otolaryngol Head Neck Surg 2020 09;146(9):789-800

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

Importance: Vertical semicircular canals and endolymphatic hydrops play important roles in the pathophysiological mechanisms of Ménière disease. However, their characteristics and associations with disease progression during medical treatment have not been determined.

Objective: To examine the function of both the horizontal and vertical semicircular canals in patients with Ménière disease and to evaluate the change in endolymphatic hydrops volume during medical treatment, including treatment with diuretic therapy, over a 2-year period. Read More

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September 2020

Hearing Preservation in Patients Who Undergo Labyrinthectomy and Translabyrinthine Procedures: A Case Report and Systematic Review.

JAMA Otolaryngol Head Neck Surg 2020 08;146(8):741-747

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston.

Importance: Preservation of endolymphatic fluids, maintenance of a fluid-filled vestibule, and preservation of the cochlear nerve and its vasculature are believed to be necessary to retaining hearing after an inner-ear operation. However, some studies have reported no hearing loss despite the violation of the vestibule, questioning the importance of maintaining a fluid-filled vestibule in preserving hearing.

Objective: To report on the preservation of hearing after a complete labyrinthectomy for Meniere disease and after disruption of the vestibule. Read More

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Endolymphatic hydrops mimicking obstructive Eustachian tube dysfunction: preliminary experience and literature review.

Eur Arch Otorhinolaryngol 2021 Feb 24;278(2):561-565. Epub 2020 Jun 24.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.

Purpose: Aural fullness is a common symptom of middle ear diseases, most importantly Eustachian tube dysfunction (ETD). Yet, aural fullness may also be caused by inner ear disorders, such as hydropic ear diseases. Here, we report our experience with endolymphatic hydrops (EH) mimicking ETD. Read More

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February 2021

Current status on researches of Meniere's disease: a review.

Acta Otolaryngol 2020 Oct 21;140(10):808-812. Epub 2020 Jun 21.

Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.

Meniere's disease (MD) is a complex and multifactorial inner ear disease. The etiology of MD is unclear. Significant progress had been made in diagnosis and treatment. Read More

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October 2020

A Micro-CT and Synchrotron Imaging Study of the Human Endolymphatic Duct with Special Reference to Endolymph Outflow and Meniere's Disease.

Sci Rep 2020 05 19;10(1):8295. Epub 2020 May 19.

Department of Surgical Sciences, Head and Neck Surgery, section of Otolaryngology, Uppsala University Hospital, Departments of Otolaryngology, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.

Meniere's disease remains enigmatic, and has no treatment with sufficient evidence. The characteristic histopathological finding is endolymphatic hydrops, suggesting either an overproduction or decreased reabsorption of endolymph in the human inner ear. This study presents the first analysis of the vascular plexus around the human endolymphatic duct using micro computed tomography and coherent synchrotron radiation with phase contrast imaging. Read More

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Automated measurement of hydrops ratio from MRI in patients with Ménière's disease using CNN-based segmentation.

Sci Rep 2020 04 24;10(1):7003. Epub 2020 Apr 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ménière's Disease (MD) is difficult to diagnose and evaluate objectively over the course of treatment. Recently, several studies have reported MD diagnoses by MRI-based endolymphatic hydrops (EH) analysis. However, this method is time-consuming and complicated. Read More

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Clinical Practice Guideline: Ménière's Disease Executive Summary.

Otolaryngol Head Neck Surg 2020 04;162(4):415-434

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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Clinical Practice Guideline: Ménière's Disease.

Otolaryngol Head Neck Surg 2020 04;162(2_suppl):S1-S55

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid (endolymph) volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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Menière's disease patients improve specific posturographic parameters following diagnostic intratympanic injection.

Am J Otolaryngol 2020 Jul - Aug;41(4):102468. Epub 2020 Mar 24.

Department of Neuroscience, Imaging e Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.

Purpose: Evaluation of specific computerized posturographic parameters in patients with Menière's disease (MD) following the intratympanic injection of gadolinium, a contrast agent, used in radiological diagnosing.

Materials And Methods: We have observed 12 adult patients with unilateral Menière's Disease subjected to inner ear magnetic resonance imaging (MRI) examination after intratympanic gadolinium injection (ITG). The diagnoses have been performed according to the guidelines of the American Academy of otolaryngology. Read More

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October 2020

Pharmacologic and surgical therapies for patients with Meniere's disease: a protocol for a systematic review and meta-analysis.

Syst Rev 2019 12 30;8(1):341. Epub 2019 Dec 30.

Center for Practice Changing Research, Ottawa Hospital Research Institute, 501 Smyth Road, Box 201B, Ottawa, ON, K1H 8 L6, Canada.

Background: Hearing loss is one of the leading causes of disability in Canada and worldwide, with more than one million Canadians enduring a hearing-related disability. Meniere's disease (MD) is a chronic condition of the inner ear, manifesting as a triad of disabling symptoms, including attacks of vertigo, fluctuating sensorineural hearing loss (SNHL), and tinnitus. Impacts on quality of life are severe, particularly with respect to restrictions in social participation and physical activity, fatigue, and reduced capacity to work. Read More

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December 2019

Revision surgery after triple semicircular canal plugging and morphologic changes of vestibular organ.

Sci Rep 2019 12 18;9(1):19397. Epub 2019 Dec 18.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250022, P.R. China.

This study aims to investigate the causes of vertigo relapse in patients with Meniere's disease (MD) who had undergone triple semicircular canal plugging (TSCP) and explore the morphologic changes of vestibular organ through revision surgery. Eleven intractable MD patients who underwent TSCP initially and experienced episodic vertigo recurrence later, were enrolled. All patients accepted revision surgery, including seven cases who underwent labyrinthectomy and four cases who underwent repeat TSCP. Read More

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December 2019

Endolymph magnetic resonance imaging: Contribution of saccule and utricle analysis in the management of patients with sensorineural ear disorders.

Authors:
A Attyé M Eliezer

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Jan 9;137(1):47-51. Epub 2019 Dec 9.

University of Grenoble Alpes, IRMaGe, 38000 Grenoble, France; Department of Neuroradiology, Lariboisière University Hospital, 75010 Paris, France.

Endolymphatic hydrops features excess endolymph in the membranous labyrinth, and is a marker of Menière's disease. Between the early 1980s and late 2000s, MRI in Menière's disease aimed purely to rule out tumor or malformation as differential diagnoses for the pressure disorder. Progress in high-resolution MRI, however, now enables excess endolymph to be visualized in the membranous labyrinth, differentiating saccule and utricle in Menière's disease and in other clinical presentations such as cochleovestibular schwannoma. Read More

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January 2020

The Physiologic Role of Corticosteroids in Menière's Disease: An Update on Glucocorticoid-mediated Pathophysiology and Corticosteroid Inner Ear Distribution.

Otol Neurotol 2020 Feb;41(2):271-276

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.

: There are multiple treatment options for Ménière's disease (MD), including dietary modifications, aminoglycoside therapy, and surgery. All have limitations, ranging from limited effectiveness to permanent hearing loss. Corticosteroids have long been used to manage MD due to their relative efficacy and tolerability, but the exact mechanism for disease alleviation is uncertain. Read More

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February 2020

Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy.

Laryngoscope 2020 08 11;130(8):2040-2046. Epub 2019 Nov 11.

Department of Sense Organs and Ear, Nose, and Throat Department, Sapienza University of Rome, Rome, Italy.

Objectives/hypothesis: To evaluate the incidence of chronic cerebrospinal venous insufficiency in Menière's disease patients and the effect of bilateral percutaneous transluminal angioplasty of the jugular/azygos veins compared to medical therapy.

Study Design: Prospective case-control study.

Methods: Five hundred fourteen subjects were included in the study, 412 affected by definite Menière's disease, and 102 healthy controls. Read More

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