335 results match your criteria Inner Ear Meniere Disease Medical Treatment


Therapeutic strategies in the treatment of Menière's disease: the Italian experience.

Eur Arch Otorhinolaryngol 2019 Apr 11. Epub 2019 Apr 11.

UOSD "Vestibologia E Otorinolaringoiatria" Presidio Ospedaliero "Giovanni Paolo II", Policoro, Italy.

Purpose: Ménière's disease (MD) is an inner ear disorder of unknown etiology, whose pathological substrate is the endolymphatic hydrops. Different treatments have been proposed; however, evidence of their effectiveness is lacking. The aim of this study was to evaluate by a questionnaire which medical and surgical treatments are used in Italy for the treatment of MD and to compare them with those proposed in other countries. Read More

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http://dx.doi.org/10.1007/s00405-019-05423-7DOI Listing
April 2019
2 Reads

Three-Dimensional Magnetic Resonance Imaging Reveals the Relationship Between the Control of Vertigo and Decreases in Endolymphatic Hydrops After Endolymphatic Sac Drainage With Steroids for Meniere's Disease.

Front Neurol 2019 4;10:46. Epub 2019 Feb 4.

Department of Otolaryngology- Head and Neck Surgery, Nara Medical University, Kashihara, Japan.

Meniere's disease is a common disease, that presents with recurrent vertigo and cochlear symptoms. The pathology of Meniere's disease was first reported to involve endolymphatic hydrops in 1938. The endolymphatic sac is thought to have a role to keep the hydrostatic pressure and endolymph homeostasis for the inner ear. Read More

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http://dx.doi.org/10.3389/fneur.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369164PMC
February 2019
14 Reads

[Possible effect of diabetes and hypertension on the quality of life of patients suffering from Ménière's disease].

Orv Hetil 2019 Jan;160(4):144-150

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Semmelweis Egyetem Budapest, Szigony u. 36., 1083.

Introduction: Ménière's disease is a disorder of the inner ear, characterized by episodic rotational vertigo, sensorineural hearing loss, tinnitus, aural pressure and vegetative symptoms. Since the improvement of these symptoms exerts an influence on the patients' quality of life and the condition seems to be incurable, the symptomatic treatment suggests an important question.

Aim: Our study's aim is to evaluate how hypertension and diabetes exert influence on the patients' quality of life and how effective conservative pharmacologic treatment is. Read More

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http://dx.doi.org/10.1556/650.2019.31256DOI Listing
January 2019
5 Reads

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237362PMC
April 2019
18 Reads

[Non-drug therapy of vertigo].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(8):38-42

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To study the efficacy of various methods of non-drug therapy of diseases manifested by vertigo and dizziness in neurological practice.

Material And Methods: Referral and final diagnoses were compared after neurovestibular examination of 599 patients (177 men and 422 women), aged 25 to 79 years (mean age 55 years), with various causes of vertigo. Patients underwent vestibular rehabilitation, trainings on the stabiloplatform with biological feedback (biofeedback), repositioning maneuvers in patients with benign paroxysmal positional vertigo (BPPV). Read More

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http://dx.doi.org/10.17116/jnevro201811808138DOI Listing
March 2019
6 Reads

[Postoperative anxiety and its relationship with life quality in patients with Ménière's diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):662-667

Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital, Beijing 100123, China.

Objective: To investigate the postoperative anxiety and its relationship with life quality in patients with Ménière's diseases.
 Methods: A total of 68 patients with Ménière's disease, who received the treatment of endolymphatic sac decompression from 2010 to 2016, were enrolled. They finished two scales (the self-rating anxiety scale and the quality of life questionnaire for endolymphatic sac decompression of Ménière's disease) by snail mail. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.06.014DOI Listing
June 2018
9 Reads

Transcanal endoscopic infracochlear vestibular neurectomy: A pilot cadaveric study.

Am J Otolaryngol 2018 Nov - Dec;39(6):731-736. Epub 2018 Aug 1.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; University of Massachusetts Medical School, Worcester, MA, USA; Department of Otolaryngology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA, USA. Electronic address:

Purpose: Effective operative approaches for the treatment of refractory vertigo in Meniere's disease are invasive. Vestibular neurectomy can preserve hearing and has been shown to be effective; however, current approaches require an extensive craniotomy. Transcanal endoscopic approaches to the internal auditory canal (IAC) with cochlear preservation have been recently described and may offer a minimally invasive approach to selectively sectioning the distal vestibular nerves while preserving residual hearing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183047
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http://dx.doi.org/10.1016/j.amjoto.2018.07.024DOI Listing
February 2019
14 Reads

[Bilateral vestibulopathy].

Authors:
R Huang G R Bi

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(24):1937-1939

Department of Neurology, Shengjing Hospital of China Medical University.

The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait, deficits of spatial memory and navigation. The etiology of BVP remains unclear in more than 50% of patients: in these cases neurodegeneration is assumed. Frequent known causes are ototoxicity mainly due to gentamicin, bilateral Menière's disease, autoimmune diseases, meningitis and bilateral vestibular schwannoma, as well as an association with cerebellar degeneration. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.24.018DOI Listing
December 2017
5 Reads

[Long-term results of endolymphatic sac mastoid drainage for Ménière disease].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):138-142

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education Beijing,100730,China.

To investigate the long-term efficacy of endolymphatic sac mastoid drainage for Ménière disease.Data from 26 patients diagnosed with MD strictly meeting the criteria issued by " Guideline of diagnosis and treatment of Meniere disease(2017)" from 2006 to 2015 were analyzed in this study.Endolymphatic sac mastoid shunt surgery was performed for each patient. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.02.015DOI Listing
January 2018
17 Reads

Effects of combined oral contraception containing drospirenone on premenstrual exacerbation of Meniere's disease: Preliminary study.

Eur J Obstet Gynecol Reprod Biol 2018 May 10;224:102-107. Epub 2018 Mar 10.

Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic, Research Group for Sexology, University of Catania, Via Santa Sofia 78, PC 95124, Catania, Italy.

Objectives: Meniere's disease is caused by an augmented endolymph pressure in the inner ear; symptoms are vertigo, fluctuating hearing loss and tinnitus. Exacerbations has been noted during premenstrual phase. The study aims to evaluate the effects of a 20 μm Ethinylestradiol (EE) and 3 mg Drospirenone (DRSP) oral contraceptive (20 μmEE/3mgDRSP) in continuous regimen, associated with rehabilitation therapy on Meniere's disease. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.03.015DOI Listing
May 2018
7 Reads

Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment.

Laryngoscope Investig Otolaryngol 2017 12 31;2(6):344-350. Epub 2017 Oct 31.

Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan.

Objective/hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Read More

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http://dx.doi.org/10.1002/lio2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743151PMC
December 2017
24 Reads

Signs of electrocochleography on endolymphatic sac decompression for patients with Ménière's Disease: Our experience in 12 patients.

Clin Otolaryngol 2018 06 25;43(3):920-923. Epub 2018 Mar 25.

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/coa.13047DOI Listing
June 2018
7 Reads

Mastoid and Inner Ear Measurements in Patients With Menière's Disease.

Otol Neurotol 2017 12;38(10):1484-1489

*Department of Otolaryngology-Head and Neck Surgery †Department of General Surgery, Detroit Medical Center, Michigan State University, Detroit ‡Department of Radiology, Michigan State University, East Lansing §Department of Otology, Neurotology, and Skull Base Surgery, Michigan Ear Institute, Farmington Hills, Michigan.

Objective: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls.

Study Design: Retrospective chart review.

Setting: Two tertiary referral centers. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001576DOI Listing
December 2017
7 Reads

Evaluation of endolymphatic hydrops using 3-T MRI after intravenous gadolinium injection.

Eur Arch Otorhinolaryngol 2017 Dec 25;274(12):4103-4111. Epub 2017 Sep 25.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.

Aim of this work is to establish evaluation criteria for identifying endolymphatic hydrops in the vestibule and cochlea using a magnetic resonance imaging (MRI) scanner. This is a retrospective diagnostic study. We evaluated 70 ears of 35 unilateral Ménière's disease patients. Read More

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http://dx.doi.org/10.1007/s00405-017-4739-9DOI Listing
December 2017
43 Reads

Evidence of surgical treatments for intractable Meniere's disease.

Authors:
Tadashi Kitahara

Auris Nasus Larynx 2018 Jun 29;45(3):393-398. Epub 2017 Jul 29.

Department of Otolaryngology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, Japan. Electronic address:

Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. Read More

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http://dx.doi.org/10.1016/j.anl.2017.07.016DOI Listing
June 2018
3 Reads

Association between ambient particulate matter and disorders of vestibular function.

Environ Res 2017 05 10;155:242-248. Epub 2017 Mar 10.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, South Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

Background: Exposure to environmental chemicals has been suggested to alter the physiologic state of the inner and middle ear. However, it is unknown if particulate matter exposure is associated with acute vestibular dysfunction.

Objectives: To estimate the effects of particulate matter exposure on the number of hospital visits related to three major diseases of vestibular dysfunction, Meniere's disease (MD), benign paroxysmal positional vertigo (BPPV), and vestibular neuronitis (VN). Read More

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http://dx.doi.org/10.1016/j.envres.2017.02.013DOI Listing
May 2017
5 Reads
2 Citations
4.373 Impact Factor

Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Am J Otolaryngol 2017 May - Jun;38(3):285-290. Epub 2017 Jan 20.

Ear, Nose, and Throat Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Objectives: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration.

Study Design: Retrospective case series and patient survey.

Setting: Tertiary university hospital. Read More

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http://dx.doi.org/10.1016/j.amjoto.2017.01.023DOI Listing
April 2018
31 Reads

The Effect of Vestibular Rehabilitation in Patients with Ménière's Disease.

Otolaryngol Head Neck Surg 2017 03 14;156(3):426-434. Epub 2016 Nov 14.

2 Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Centre, The Netherlands.

Objective To systematically review the evidence on the effect of vestibular rehabilitation in patients with Ménière's disease (MD) on balance and dizziness-related quality of life. Data Sources A literature search was conducted in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Web of Science, and CINAHL databases. Review Methods Articles were reviewed by 2 independent authors and data were compiled in tables for analysis regarding balance (ie, posturography) and dizziness-specific quality of life in patients with MD. Read More

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http://dx.doi.org/10.1177/0194599816678386DOI Listing
March 2017
26 Reads

Intraoperative Electrocochleography: A Window Into Endolymphatic Hydrops in a Patient With an Endolymphatic Sac Tumor.

Otol Neurotol 2017 04;38(4):547-550

*Department of Otolaryngology, The Ohio State University Wexner Medical Center, Ohio †Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Objectives: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops.

Patients: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. Read More

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http://Insights.ovid.com/crossref?an=00129492-201704000-0001
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http://dx.doi.org/10.1097/MAO.0000000000001340DOI Listing
April 2017
10 Reads

Diagnostic and therapeutic strategy in Menière's disease. Guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (SFORL).

Eur Ann Otorhinolaryngol Head Neck Dis 2017 Dec 3;134(6):441-444. Epub 2017 Jan 3.

Inserm UMR 1107, service ORL, laboratoire de biophysique neurosensorielle, université d'Auvergne, CHU Gabriel-Montpied, Clermont-Ferrand, France. Electronic address:

Objectives: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou: SFORL) for diagnostic and therapeutic strategy in Menière's disease.

Methods: A work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, then read over by an editorial group independent of the work group. Read More

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http://dx.doi.org/10.1016/j.anorl.2016.12.003DOI Listing
December 2017
5 Reads

Intratympanic steroids injection is effective for the treatment of drop attacks with Ménière's disease and delayed endolymphatic hydrops: A retrospective study.

Medicine (Baltimore) 2016 Dec;95(52):e5767

Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, PR China.

Drop attack (DA) associated with Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is not common and may cause life-threatening clinical problems. The intratympanic dexamethasone (ITD) is one of primary treatments for MD or DEH. Our study investigated the effect of ITD on the DA associated with endolymphatic hydrops (EH). Read More

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http://dx.doi.org/10.1097/MD.0000000000005767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207592PMC
December 2016
10 Reads

Endolymphatic Duct Blockage for Refractory Ménière's Disease: Assessment of Endolymphatic Sac Biopsy on Short-Term Surgical Outcomes.

J Int Adv Otol 2016 Dec;12(3):310-315

Division of Otolaryngology-Head-Neck Surgery, University of Montreal Hospital Centre (CHUM), Montreal, QC, Canada.

Objective: Endolymphatic sac decompression (ESD) for the treatment of Ménière's disease (MD) has had limited success and variable results in the literature. We have devised a novel technique that involves blocking the endolymphatic duct with surgical clips. In a separate effort to study the endolymphatic sac (ELS), we have sectioned the lateral part of the main body of the ELS as biopsies from a subset of patients. Read More

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http://dx.doi.org/10.5152/iao.2016.3069DOI Listing
December 2016
38 Reads

Endolymphatic sac drainage for the treatment of Ménière's disease.

J Laryngol Otol 2017 Feb 15;131(2):144-149. Epub 2016 Dec 15.

Otorhinolaryngology Department,Faculty of Medicine,Hospital das Clínicas,University of São Paulo,Brazil.

Objective: To describe the results obtained with endolymphatic sac drainage in patients with Ménière's disease.

Method: A retrospective case review study was conducted of 95 Ménière's disease patients who underwent endolymphatic sac drainage in a tertiary care referral centre, after failing a long course of medical management. The main outcome measures were vertigo control and hearing preservation. Read More

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http://dx.doi.org/10.1017/S0022215116009713DOI Listing
February 2017
7 Reads

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015).

Expert Opin Ther Pat 2017 Feb 18;27(2):191-202. Epub 2016 Nov 18.

a Department of Chemistry , University of Southern California , Los Angeles , CA , USA.

Introduction: Inner ear disorders such as hearing loss, tinnitus, and Ménière's disease significantly impact the quality of life of affected individuals. Treatment of such disorders is an ongoing challenge. Current clinical approaches relieve symptoms but do not fully restore hearing, and the search for more effective therapeutic methods represents an area of urgent current interest. Read More

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http://dx.doi.org/10.1080/13543776.2017.1252751DOI Listing
February 2017
11 Reads

Changes in endolymphatic hydrops visualized by magnetic resonance imaging after sac surgery.

J Huazhong Univ Sci Technolog Med Sci 2016 Oct 18;36(5):736-740. Epub 2016 Oct 18.

Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China.

The purpose of the study was to observe changes in endolymphatic hydrops by using intratympanic injection of gadolinium and magnetic resonance imaging (MRI) before and after endolymphatic sac surgery in patients with unilateral Meniere's disease. Thirteen patients with unilateral Meniere's disease undergoing endolymphatic sac surgery were retrospectively and prospectively analyzed. Three-dimensional fluid-attenuated inversion recovery or three-dimensional real inversion recovery MRI was performed 24 h after an intratympanic injection of gadolinium to grade the presence of endolymphatic hydrops. Read More

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http://dx.doi.org/10.1007/s11596-016-1654-zDOI Listing
October 2016
21 Reads
0.780 Impact Factor

Meniett device in meniere disease: Randomized, double-blind, placebo-controlled multicenter trial.

Laryngoscope 2017 02 12;127(2):470-475. Epub 2016 Aug 12.

Department of Otology Auditory Implants and Skull Base Surgery, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.

Objective: To evaluate the efficacy of portable Meniett low-pressure pulse generator (Medtronic Xomed, Jacksonville, FL) in Meniere disease.

Study Design: Randomized, double-blind, placebo-controlled, multicenter trial carried out in 17 academic medical centers.

Methods: One hundred twenty-nine adults presenting Meniere disease (American Academy of Otolaryngology-Head and Neck Surgery criteria) not controlled by conventional medical treatment were included. Read More

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http://dx.doi.org/10.1002/lary.26197DOI Listing
February 2017
17 Reads

Incidence of Hypothyroidism in Meniere's Disease.

J Clin Diagn Res 2016 May 1;10(5):MC01-3. Epub 2016 May 1.

Post Graduate Student, Department of ENT, JJM Medical College , Davanagere, Karnataka, India .

Introduction: Meniere's disease is a disorder of the membranous labyrinth of the inner ear manifesting as vertigo, tinnitus, sensory neural hearing loss and aural fullness of known or unknown origin. Some patients may present after years into typical forms. The endocrine disorders, especially hypothyroidism and the factors like inflammation, trauma, otosclerosis, autoimmunity explains the multifactorial causation for the basis of Meniere's disease. Read More

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http://dx.doi.org/10.7860/JCDR/2016/17587.7759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948427PMC
May 2016
5 Reads

Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease.

Eur Arch Otorhinolaryngol 2017 Jan 15;274(1):85-93. Epub 2016 Jul 15.

German Center for Vertigo and Balance Disorders and Department of Otorhinolaryngology-Head and Neck Surgery, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

To determine whether vestibular evoked myogenic potential (VEMP) measurements that combine the VEMP 500/1000 Hz frequency tuning ratio and the inter-aural asymmetry ratio can reliably detect unilateral Meniere's disease ears as compared to healthy controls. Forty-two consecutive patients with certain unilateral Meniere's disease (as confirmed using a locally enhanced inner ear MRI (LEIM)) were assessed. Cervical vestibular evoked myogenic potentials (cVEMP) and ocular vestibular evoked myogenic potentials (oVEMP) were recorded at 500 and 1000 Hz. Read More

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http://dx.doi.org/10.1007/s00405-016-4206-zDOI Listing
January 2017
7 Reads

A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere's Disease-A Pilot Study.

PLoS One 2016 30;11(6):e0158309. Epub 2016 Jun 30.

Department of Otolaryngology, Nara Medical University, Kashihara-city, Nara, Japan.

Unlabelled: Meniere's disease, a common inner ear condition, has an incidence of 15-50 per 100,000. Because mental/physical stress and subsequent increase in the stress hormone vasopressin supposedly trigger Meniere's disease, we set a pilot study to seek new therapeutic interventions, namely management of vasopressin secretion, to treat this disease. We enrolled 297 definite Meniere's patients from 2010 to 2012 in a randomized-controlled and open-label trial, assigning Group-I (control) traditional oral medication, Group-II abundant water intake, Group-III tympanic ventilation tubes and Group-IV sleeping in darkness. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928871PMC
July 2017
18 Reads

Cochlear Patency After Transmastoid Labyrinthectomy for Ménière's Syndrome.

Otol Neurotol 2016 08;37(7):937-9

*Michigan Ear Institute, Wayne State University School of Medicine, and Providence Hospital and Medical Center †Department of Radiology, Providence Hospital and Medical Center, Farmington Hills, Michigan.

Objective: Labyrinthectomy is considered the "gold standard" in the treatment of intractable vertigo attacks because of Ménière's Disease (MD) but sacrifices all residual hearing. Interest in auditory rehabilitation has lead to cochlear implantation in some patients. Concern remains that the cochlear lumen may fill with tissue or bone after surgery. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001105DOI Listing
August 2016
1 Read

The physiologic role of corticosteroids in Ménière's disease.

Am J Otolaryngol 2016 Sep-Oct;37(5):455-8. Epub 2016 May 4.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Multiple options exist to manage Ménière's disease (MD), ranging from dietary modifications to ablative surgery. Corticosteroids (CS) have long been used to manage MD, but their exact mechanism for disease alleviation is relatively uncertain. Glucocorticoid receptors have been shown to exist in the human inner ear and several studies propose they influence mechanisms of blood flow, fluid regulation, and ion regulation, with recent evidence describing the latter two. Read More

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http://dx.doi.org/10.1016/j.amjoto.2016.04.004DOI Listing
March 2017
4 Reads

Meniere's disease.

Nat Rev Dis Primers 2016 05 12;2:16028. Epub 2016 May 12.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Meniere's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiology of MD is multifactorial. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. Read More

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http://dx.doi.org/10.1038/nrdp.2016.28DOI Listing
May 2016
18 Reads

Endolymphatic space size in patients with Meniere's disease and healthy controls.

Acta Otolaryngol 2016 Sep 15;136(9):879-82. Epub 2016 Apr 15.

a Department of Otolaryngology - Head and Neck Surgery , Nara Medical University , Sakurai , Nara , Japan ;

Conclusions: The incident ratios of cochlear and/or vestibular endolymphatic hydrops (EH) were significantly higher in the affected ears of patients with Meniere's disease (MD) than in the ears of healthy controls. There were no significant differences between controls and the contralateral ears of MDs.

Objectives: The aim was to compare the incidence ratios of EH between unilateral/bilateral MD and controls using 3T magnetic resonance imaging (MRI) with intravenous gadolinium. Read More

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http://dx.doi.org/10.3109/00016489.2016.1169556DOI Listing
September 2016
3 Reads

An approach to vertigo in general practice.

Aust Fam Physician 2016 Apr;45(4):190-4

Background: Dizziness is a common and very distressing presentation in general practice. In more than half of these cases, the dizziness is due to vertigo, which is the illusion of movement of the body or its surroundings. It can have central or peripheral causes, and determining the cause can be difficult. Read More

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April 2016
9 Reads

Hormonal changes following a low-salt diet in patients with Ménière's disease.

Auris Nasus Larynx 2017 Feb 28;44(1):52-57. Epub 2016 Mar 28.

Department of Otolaryngology, Kagawa University, Kagawa, Japan; Osaka Bay Central Hospital, Japan.

Objective: A low-salt diet has been the main treatment modality for Ménière's disease (MD) since the 1930s, although the mechanisms behind this therapy have not yet been elucidated. Salt reduction is associated with a physiological increase in plasma aldosterone concentration. Several experimental reports have suggested that aldosterone may increase endolymph absorption in the inner ear, particularly in the endolymphatic sac. Read More

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http://dx.doi.org/10.1016/j.anl.2016.03.001DOI Listing
February 2017
12 Reads

Identification of operculum and surgical results in endolymphatic sac drainage surgery.

Auris Nasus Larynx 2017 Feb 19;44(1):116-118. Epub 2016 Mar 19.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan.

To increase the accuracy of identification of the endolymphatic sac during endolymphatic sac drainage surgery, we focused on the intra-operative identification of the operculum as a structural marker of the endolymphatic sac and the vestibular aqueduct at the rugose portion. Then, we examined the relationship between identification of the operculum and surgical outcomes. We used 100 cases with intractable Meniere's disease who received endolymphatic sac drainage with local steroid administration, superior to traditional endolymphatic sac drainage surgery and non-surgical medical treatment. Read More

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http://dx.doi.org/10.1016/j.anl.2016.02.017DOI Listing
February 2017
7 Reads

Vestibular results after intratympanic gentamicin therapy in disabling Menière's disease.

Eur Arch Otorhinolaryngol 2016 Oct 16;273(10):3011-8. Epub 2016 Jan 16.

Department of Otolaryngology-Head and Neck Surgery, University of Grenoble, Grenoble, France.

Intratympanic injection of gentamicin is increasingly used in the treatment of unilateral disabling Menière's disease (MD). Several objective functional and subjective tests have been developed to assess the control of vertigo after gentamicin treatment. The aim of this study was to show that subjective results require a vestibular deafferentation as profound as possible, evidenced with multifrequency vestibular assessment. Read More

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http://dx.doi.org/10.1007/s00405-015-3889-xDOI Listing
October 2016
9 Reads

Dehydration effects of a V2 antagonist on endolymphatic hydrops in guinea pigs.

Hear Res 2016 Feb 21;332:151-159. Epub 2015 Dec 21.

Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

We investigated the influence of vasopressin type 2 receptor antagonist (OPC-41061; Tolvaptan) on experimentally induced endolymphatic hydrops (EH) in guinea pigs. In the first series, the endolymphatic sac (ES) of the left ear of all animals was electrocauterized. Four weeks after surgery, the animals were allocated to four groups: three systemic applications groups (saline, OPC 10 and 100 mg/kg) and a local round window (RW) OPC 1 mg/body application group. Read More

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http://dx.doi.org/10.1016/j.heares.2015.12.017DOI Listing
February 2016
12 Reads

Current evidence for endolymphatic sac surgery in the treatment of Meniere's disease: a systematic review.

Singapore Med J 2015 Nov;56(11):593-8

Mount Elizabeth Medical Centre, Singapore.

This paper aims to identify emerging evidence for endolymphatic sac surgery (ESS) in the treatment of Meniere's disease since the landmark study by Thomsen et al, published in 1998 (conducted from 1981 to 1989). Using the MEDLINE database (PubMed), a systematic review of the literature published from January 1990 to June 2014 was performed. We included all English-language, peer-reviewed randomised controlled trials (RCTs) and controlled studies. Read More

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http://dx.doi.org/10.11622/smedj.2015166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656865PMC
November 2015
11 Reads
0.634 Impact Factor

Surgical results and psychological status in patients with intractable Ménière's disease.

Auris Nasus Larynx 2016 Jun;43(3):287-91

Department of Otolaryngology - Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

Objectives: Mental disorder is often one of the causes to make treatments for Ménière's disease more difficult. The aim in the present study is to examine ratios of the neurosis and depression in patients with intractable Ménière's disease and also relationships between the ratios and surgical results after endolymphatic sac drainage with large doses of steroids.

Methods: Between 1998 and 2009, we enrolled 263 intractable Ménière's patients and divided into two groups, 207 in surgical group and 56 in non-surgical group. Read More

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http://dx.doi.org/10.1016/j.anl.2015.10.007DOI Listing
June 2016
22 Reads

Modified titration intratympanic gentamicin injection for unilateral intractable Ménière's disease.

J Huazhong Univ Sci Technolog Med Sci 2015 Oct 22;35(5):747-751. Epub 2015 Oct 22.

Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

This study looked into the efficacy of a modified titration protocol of intratympanic gentamicin injection (ITG) in the patients with unilateral intractable Ménière's disease (MD). Modified titration protocol of ITG at a low dose (20 mg/mL) was administered to 10 patients with definite unilateral intractable MD. After initial first two fixed ITGs on weekly basis, the patients might or might not be given any more injections, depending on the appearance of unilateral vestibular loss (UVL). Read More

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http://dx.doi.org/10.1007/s11596-015-1501-7DOI Listing
October 2015
15 Reads

Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease.

Laryngoscope 2015 Dec 7;125 Suppl 12:S1-12. Epub 2015 Sep 7.

House Clinic, Los Angeles, California, U.S.A.

Objectives/hypothesis: 1) To establish criteria for significant hearing fluctuation by assessing the range and occurrence of hearing fluctuations over the course of Meniere's disease; 2) to determine if audiometric evidence exists to support the notion that Meniere's disease is a pathophysiologic process involving the whole cochlea; and 3) to suggest prognostic implications for initial hearing fluctuation in patients with Meniere's disease.

Study Design: Retrospective case series review.

Methods: A total of 488 patients diagnosed by 1995 American Academy of Otolaryngology-Head and Neck Surgery Meniere's disease criteria for whom audiometric data were prospectively collected (2 cohorts: 341 and 146 patients initially seen between April 2002 to July 2003 and between January to December 2010, respectively). Read More

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http://dx.doi.org/10.1002/lary.25579DOI Listing
December 2015
16 Reads

Is low-dose intratympanic gentamicin an effective treatment for Ménière's disease: the Birmingham experience.

J Laryngol Otol 2015 Oct 2;129(10):970-3. Epub 2015 Sep 2.

Department of Otolaryngology,Head and Neck Surgery,Queen Elizabeth Hospital,Birmingham,UK.

Background: Since the development of intratympanic aminoglycoside in the 1950s, otologists have been able to chemically ablate the vestibule. We present the results of using low-dose intratympanic gentamicin to treat Ménière's disease.

Method: A retrospective review was performed of all patients who underwent low-dose intratympanic gentamicin therapy over seven years. Read More

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http://dx.doi.org/10.1017/S0022215115002200DOI Listing
October 2015
8 Reads

Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease.

Eur Arch Otorhinolaryngol 2016 Jul 25;273(7):1705-10. Epub 2015 Jul 25.

Department of Oto-rhino-laryngology, Head and Neck Surgery, and Audiology, Coepnhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

The human endolymphatic sac (ES) is situated in a duplicature of the dura in the posterior cranial fossa and constitutes a part of the inner ear. The sac possesses immunological capacities and is responsible for a major part of the trans-epithelial ion transport occurring within the inner ear, via molecular mechanisms similar to that of the kidney collecting duct epithelia. Dysfunction of the trans-epithelial ion transport has been hypothesized as the reason for the endolymphatic hydrops occurring in Menieres diseases. Read More

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http://link.springer.com/content/pdf/10.1007%2Fs00405-015-37
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http://link.springer.com/10.1007/s00405-015-3731-5
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http://dx.doi.org/10.1007/s00405-015-3731-5DOI Listing
July 2016
6 Reads

Some Remarks on Imaging of the Inner Ear: Options and Limitations.

Clin Neuroradiol 2015 Oct 8;25 Suppl 2:197-203. Epub 2015 Jul 8.

Department of Diagnostic and Interventional Neuroradiology, Klinikum Fulda (University Medicine Marburg, Campus Fulda), Fulda, Germany.

The temporal bone has a highly complex anatomical structure, in which the sensory organs of the cochlea and the vestibular system are contained within a small space together with the sound-conducting system of the middle ear. Detailed imaging is thus required in this anatomical area. There are a great many clinical aims for which the highest-possible spatial resolution is required. Read More

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http://link.springer.com/content/pdf/10.1007/s00062-015-0422
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http://link.springer.com/10.1007/s00062-015-0422-y
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http://dx.doi.org/10.1007/s00062-015-0422-yDOI Listing
October 2015
8 Reads

The Prevalence of Cochlear Obliteration After Labyrinthectomy Using Magnetic Resonance Imaging and the Implications for Cochlear Implantation.

Otol Neurotol 2015 Sep;36(8):1328-30

ENT Department, St. Vincent's Public Hospital, Darlinghurst, Sydney, New South Wales, Australia.

Objectives: The aim of this study was to determine the prevalence of cochlear obliteration after labyrinthectomy.

Study Design: Retrospective review of medical records.

Setting: Tertiary referral center. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MAO.0000000000000803DOI Listing
September 2015
9 Reads

Intratympanic dexamethasone injections for refractory Meniere' s disease.

Int J Clin Exp Med 2015 15;8(4):6016-23. Epub 2015 Apr 15.

Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China.

Intratympanic injections or titration is a potential medical therapeutic strategy for patients with incurable inner ear diseases. Dexamethasone represent an attractive steroid source in intratympanic steroids strategies in the treatment of inner ear disorders. Here, we evaluated the effectiveness of intratympanic dexamethasone injections (IDI) in outpatients with refractory Meniere's disease (MD). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483845PMC
July 2015
9 Reads

Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI.

Hear Res 2015 Dec 3;330(Pt A):119-24. Epub 2015 Jun 3.

Department of Otorhinolaryngology, Clinical Sciences, Lund University & Skåne University Hospital, Lund, Sweden.

From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play a critical role in endolymph homeostasis and may be involved in the development of Ménière's disease. Read More

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http://dx.doi.org/10.1016/j.heares.2015.05.008DOI Listing
December 2015
7 Reads

Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research.

Ann N Y Acad Sci 2015 Apr;1343:27-36

Department of Neurology, German Center for Vertigo and Balance Disorders and Institute for Clinical Neurosciences, University Hospital Munich, Campus Grosshadern, Munich, Germany.

There are currently eight groups of drugs for the pharmacotherapy of vertigo, nystagmus, and cerebellar disorders: antiemetics; anti-inflammatories, antimenieres, and antimigraineous medications; antidepressants, anticonvulsants, aminopyridines, and acetyl-DL-leucine ("the eight A's"). In acute unilateral vestibulopathy, corticosteroids improve the recovery of peripheral vestibular function, but there is not sufficient current evidence for a general recommendation. There is also insufficient evidence that 48 or 144 mg/day betahistine has an effect in Ménière's disease. Read More

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http://dx.doi.org/10.1111/nyas.12774DOI Listing
April 2015
10 Reads

Cell-specific accumulation patterns of gentamicin in the guinea pig cochlea.

Hear Res 2015 Aug 13;326:40-8. Epub 2015 Apr 13.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address:

Intratympanic gentamicin therapy has become a popular treatment modality for Ménière's disease (MD) through controlled elimination of vertigo spells caused by the balance organ. However, the known ototoxic properties of aminoglycosides lead to cochlear damage. In order to gain more information about cellular preferences for aminoglycoside accumulation within the cochlea, gentamicin was immuno histochemically localized by light microscopy in male guinea pigs 1 and 7 days after intratympanic application (n = 8 ears/incubation time). Read More

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http://dx.doi.org/10.1016/j.heares.2015.03.010DOI Listing
August 2015
4 Reads