409 results match your criteria Inner Ear Meniere Disease Medical Treatment


NaCl exposure results in increased expression and processing of IL-1β in Meniere's disease patients.

Sci Rep 2022 03 23;12(1):4957. Epub 2022 Mar 23.

The Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Meniere's disease (MD) is a chronic disease that causes episodic vertigo, fluctuating hearing loss, and aural fullness, initially managed by dietary salt reduction, and use of diuretics. Our prior research in autoimmune inner ear disease (AIED) demonstrated that in peripheral blood mononuclear cell (PBMC) from corticosteroid-resistant AIED patients, increased production, processing and release of interleukin-1β (IL-1β) is observed and hearing could be improved with use of anakinra, an interleukin-1 receptor antagonist. We have further identified that in these AIED patients, IL-1β is uniquely processed to a 28 kDa pro-inflammatory product by caspase-7. Read More

View Article and Full-Text PDF

[The effectiveness of transtympanic use of dexamethasone 4 mg in Meniere's disease, severe and moderate course of the disease].

Vestn Otorinolaringol 2022 ;87(1):21-26

Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia.

The results of transtympanic administration of 4 mg dexamethasone in 37 patients with moderate and severe Meniere's disease are presented. The endolymphatic hydrops was detected in all inner ear structures with predominant accumulation in vestibule and semicircular canals by MRI-visualization before therapy. After 1 month of 4 mg dexamethasone transtympanic therapy the hydrops degree decreased. Read More

View Article and Full-Text PDF

Vestibular Nerve Section via Middle Cranial Fossa Approach.

Otol Neurotol 2022 04;43(4):e529

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Vestibular nerve section (VNS) is a surgical intervention with hearing preservation used for the treatment of Menière's disease after conservative medical therapy has failed (1,2). With the recent rise in less invasive treatments such as intratympanic gentamicin, VNS has been performed less frequently (3). The middle cranial fossa (MCF) approach for VNS is an uncommon approach due to its technical difficulty. Read More

View Article and Full-Text PDF

Pathogenesis and Etiology of Ménière Disease: A Scoping Review of a Century of Evidence.

JAMA Otolaryngol Head Neck Surg 2022 04;148(4):360-368

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston.

Importance: Ménière disease is a rare chronic benign disorder of the inner ear with a natural history of multiple clinical phenotypes of variable severity and a tendency to burnout with time. Although multiple treatment modalities have been shown to improve the disease process-some adversely affecting cochleovestibular function-it remains uncertain whether one, several separate, or a combination of pathophysiologic mechanisms affect the disease process. A scoping review of the evidence underlying proposed pathophysiologic mechanisms of Ménière disease is needed to determine which processes are most likely to be etiopathogenic factors. Read More

View Article and Full-Text PDF

Occlusal splint therapy in patients with Ménière's disease and temporomandibular joint disorder.

Acta Otorhinolaryngol Ital 2022 Feb 7;42(1):89-96. Epub 2022 Feb 7.

Medical Toxicology-headache and Drug Abuse Research Center, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Objective: This retrospective study aimed to verify the outcomes of stabilising occlusal splint therapy prescribed to 22 patients with unilateral definite Ménière's disease and comorbid temporomandibular joint disorder.

Methods: The results of a battery of audiometric and vestibular tests were recorded before and after 6 months of treatment, as well as the scores of disease-specific questionnaires.

Results: The average hearing threshold in the affected ear and the acoustic immittance were unchanged. Read More

View Article and Full-Text PDF
February 2022

Meniere disease subtyping: the direction of diagnosis and treatment in the future.

Expert Rev Neurother 2022 Feb 22;22(2):115-127. Epub 2022 Feb 22.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: Meniere's disease (MD) is a chronic disorder of inner ear, characterized by audial and vestibular symptoms. It presents a great variability among patients in terms of clinical features, etiology, pathology, and response to the same therapy. It's challenging to diagnose and manage for its heterogeneity. Read More

View Article and Full-Text PDF
February 2022

A Historical Perspective on Surgical Manipulation of the Membranous Labyrinth for Treatment of Meniere's Disease.

Front Neurol 2021 23;12:794741. Epub 2021 Dec 23.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.

Meniere's disease is an inner ear disorder without a known cause. Endolymphatic hydrops is a swelling of the endolymph spaces that has been observed consistently on post-mortem histology in patients with a history of Meniere's disease but can occur in asymptomatic individuals and in association with other diseases. Since its discovery, Meniere's disease has been a disorder managed primarily by otolaryngologists. Read More

View Article and Full-Text PDF
December 2021

Changes in endolymphatic hydrops after vestibular neurectomy observed in magnetic resonance imaging - A pilot study.

Auris Nasus Larynx 2022 Aug 20;49(4):584-592. Epub 2021 Dec 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland.

Objectives: The aim was to evaluate endolymphatic hydrops in patients with Ménière's disease before and after vestibular neurectomy to verify if the endolymphatic space dilatation, observed in magnetic resonance imaging, regressed within several months after surgery.

Methods: Magnetic resonance imaging was performed after intravenous gadolinium injection in four patients with unilateral definite Ménière's disease before and eight months after vestibular neurectomy. Clinical symptoms, audiovestibular tests, and endolymphatic hydrops in magnetic resonance imaging were evaluated. Read More

View Article and Full-Text PDF

Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences.

Eur Radiol 2022 May 20;32(5):3532-3540. Epub 2021 Dec 20.

Univ. Bordeaux, Institut de Bio-imagerie IBIO, 33000, Bordeaux, France.

Objectives: 3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière's disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.

Methods: 3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Read More

View Article and Full-Text PDF

[Clinical significance of radiological methods for diagnosing endolymphatic hydrops in Ménière's disease].

Vestn Otorinolaringol 2021 ;86(5):82-89

Sechenov First Moscow State Medical University, Moscow, Russia.

Ménière's disease is a chronic disorder of the inner ear, a permanent sing of which is endolymphatic hydrops. For the diagnosis of Ménière's disease in clinical practice, criteria that are primarily based on the clinical picture. However, instrumental methods for diagnosing Ménière's disease, aimed at identifying endolymphatic hydrops, continue to be developed and improved. Read More

View Article and Full-Text PDF
November 2021

[Analysis of clinical characteristics and risk factors in patients with benign paroxysmal positional vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Oct;35(10):905-909

The Third District,Department of Neurology,the First People's Hospital of Chenzhou City,Chenzhou,423000,China.

〓 Objective: To analyze the clinical characteristics of patients with benign paroxysmal positional vertigo, summarize experience for diagnosis and treatment activities and to explore the risk factors related to the onset of BPPV and provide reference for early intervention to reduce the risk factor exposure of BPPV. One hundred and twelve patients with BPPV were included in the study, and clinical data including age, gender, onset symptoms and duration, past medical history and family history were analyzed. A One-way ANOVA was performed on 16 variables using age, gender, diabetes, hyperuric acid, hyperlipidemia, osteoporosis, hypertension, coronary heart disease, stroke, Meniere's disease, suppurative otitis media, vestibular neuronitis, sudden deafness, head injury, ear nose/maxillofacial surgery and autoimmune thyroiditis. Read More

View Article and Full-Text PDF
October 2021

Intraoperative Electrocochleography in Subjects Affected by Vestibular Schwannoma and Ménière's Disease: Comparison of Results.

Ear Hear 2022 May/Jun;43(3):874-882

Department of Otolaryngology-Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Objectives: Histologic reports of temporal bones of ears with vestibular schwannomas (VSs) have indicated findings of endolymphatic hydrops (ELH) in some cases. The main goal of this investigation was to test ears with VSs to determine if they exhibit electrophysiological characteristics similar to those of ears expected to experience ELH.

Design: Fifty-three subjects with surgically confirmed VS aged ≥18 and with normal middle ear status were included in this study. Read More

View Article and Full-Text PDF

A Fully Automated Analytic System for Measuring Endolymphatic Hydrops Ratios in Patients With Ménière Disease via Magnetic Resonance Imaging: Deep Learning Model Development Study.

J Med Internet Res 2021 09 21;23(9):e29678. Epub 2021 Sep 21.

Department of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.

Background: Recently, the analysis of endolymphatic hydropses (EHs) via inner ear magnetic resonance imaging (MRI) for patients with Ménière disease has been attempted in various studies. In addition, artificial intelligence has rapidly been incorporated into the medical field. In our previous studies, an automated algorithm for EH analysis was developed by using a convolutional neural network. Read More

View Article and Full-Text PDF
September 2021

Magnetic resonance imaging with intravenous gadoteridol injection based on 3D-real IR sequence of the inner ear in Meniere's disease patient: feasibility in 3.5-h time interval.

Acta Otolaryngol 2021 Oct 14;141(10):899-906. Epub 2021 Sep 14.

Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai, PR China.

Background: Intravenous gadoteridol injection can be applied to visualize endolymphatic hydrops (EH).

Aims/objectives: To explore whether 3.5-h time interval was feasible for clinical practice. Read More

View Article and Full-Text PDF
October 2021

Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex.

Exp Ther Med 2021 Oct 13;22(4):1177. Epub 2021 Aug 13.

Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China.

Endolymphatic hydrops is a characteristic pathological manifestation of Meniere's disease (MD) that has been previously associated with autoimmunity. Interest in the circulating immune complex (CIC) has increased due to its reported role in the occurrence of MD. The present study aimed to investigate the potential value of serum CIC concentration in the diagnosis of MD and the therapeutic potential of cyclophosphamide (CTX) for the treatment of MD. Read More

View Article and Full-Text PDF
October 2021

Posterior petrous face meningiomas presenting with Ménière's-like syndrome: a case series and review of the literature.

J Neurosurg 2022 Feb 27;136(2):441-448. Epub 2021 Aug 27.

Departments of1Neurological Surgery and.

Objective: Ménière's disease is an inner ear disorder classically characterized by fluctuating hearing loss, tinnitus, and aural fullness accompanied by episodic vertigo. While the pathogenesis of Ménière's remains under debate, histopathological analyses implicate endolymphatic sac dysfunction with inner ear fluid homeostatic dysregulation. Little is known about whether external impingement of the endolymphatic sac by tumors may present with Ménière's-like symptoms. Read More

View Article and Full-Text PDF
February 2022

Effectiveness of endolymphatic duct blockage versus endolymphatic sac decompression in patients with intractable Ménière's disease: study protocol for a double-blinded, randomised controlled trial.

BMJ Open 2021 08 10;11(8):e054514. Epub 2021 Aug 10.

Department of Otorhinolaryngology, Haga Hospital, The Hague, The Netherlands.

Introduction: Outcomes of surgery for Ménière's disease (MD) remain discordant. Recently, a new surgical procedure in which the endolymphatic duct is clipped was proposed. To date, only one prospective trial assessing this technique was published, yielding promising results. Read More

View Article and Full-Text PDF

Investigation of endolymphatic hydrops positivity rates in patients with recurrent audiovestibular symptoms using inner ear magnetic resonance imaging.

Auris Nasus Larynx 2022 Apr 17;49(2):188-194. Epub 2021 Jun 17.

Department of Otolaryngology, Takai Hospital, Nara, Japan.

Objectives: This study aimed to investigate the endolymphatic hydrops (EH)-positivity rates among patients with recurrent audiovestibular symptoms using intravenous injection of gadolinium-enhanced inner ear magnetic resonance imaging (ieMRI).

Methods: We reviewed 710 successive patients with recurrent audiovestibular symptoms at the Vertigo/Dizziness Center of Nara Medical University and other related hospitals, between May 2014 and April 2020. We performed ieMRI on 153 patients with unilateral recurrent cochleovestibular symptoms (rCV), 51 with recurrent vertigo symptoms (rVO), and 84 with unilateral recurrent cochlear symptoms (rCO). Read More

View Article and Full-Text PDF

First-in-human intracochlear application of human stromal cell-derived extracellular vesicles.

J Extracell Vesicles 2021 06 4;10(8):e12094. Epub 2021 Jun 4.

Department of Transfusion Medicine University Hospital Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU) Salzburg Austria.

Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti-inflammatory effects. MSC-EVs may serve as promising cell-based therapeutics for the inner ear to attenuate inflammation-based side effects from cochlear implantation which represents an unmet clinical need. In an individual treatment performed on a 'named patient basis', we intraoperatively applied allogeneic umbilical cord-derived MSC-EVs (UC-MSC-EVs) produced according to good manufacturing practice. Read More

View Article and Full-Text PDF

Cochlear Implantation in the Setting of Menière's Disease After Labyrinthectomy: A Meta-Analysis.

Otol Neurotol 2021 09;42(8):e973-e979

Department of Otolaryngology, Head and Neck Surgery, University of North Carolina at Chapel Hill, North Carolina.

Objective: Characterize the speech recognition and sound source localization of patients with unilateral Menière's disease who undergo labyrinthectomy for vertigo control with simultaneous or sequential cochlear implantation.

Databases Reviewed: PubMed, Embase, and Cochrane databases.

Methods: The search was performed on May 6, 2020. Read More

View Article and Full-Text PDF
September 2021

Cochlear Implantation Hearing Outcome in Ménière's Disease.

Otolaryngol Head Neck Surg 2022 03 18;166(3):523-529. Epub 2021 May 18.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective: The aim of this study was to evaluate the hearing outcome of cochlear implantation in patients deafened by Ménière's disease.

Study Design: Retrospective single-institution study.

Setting: Tertiary medical center. Read More

View Article and Full-Text PDF

Magnetic resonance imaging of the inner ear in the diagnostics of Ménière's disease.

Otolaryngol Pol 2020 Dec;75(2):1-8

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD.

Ménière's disease is characterized by sudden episodes of vertigo accompanied by tinnitus and/or feeling of fullness in the ear as well as fluctuating sensorineural hearing loss. Despite numerous studies, the etiology of this disease remains unknown. However, the enlargement of the inner ear's endolymphatic spaces, referred to as endolymphatic hydrops, is considered the underlying condition. Read More

View Article and Full-Text PDF
December 2020

Changes in the Results of the Subjective Visual Vertical Test After Endolymphatic Sac Drainage for Intractable Meniere's Disease.

J Int Adv Otol 2021 Mar;17(2):121-126

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara City, Nara, Japan.

Objective: To investigate otolithic function before and after endolymphatic sac drainage (ELSD) for Meniere's disease (MD) by using the subjective visual vertical test (SVV) in the upright and tilted positions.

Methods: Eighteen patients with definite unilateral MD diagnosed in accordance with the American Academy of Otolaryngology Head and Neck Surgery criteria in 1995 and Barany Society criteria in 2015 were included. SVV in the upright position and the head-tilt position was performed preoperatively and on postoperative days 1, 5, 8, 28, and 112. Read More

View Article and Full-Text PDF

Correlation between magnetic resonance imaging classification of endolymphatic hydrops and clinical manifestations and audiovestibular test results in patients with definite Ménière's disease.

Auris Nasus Larynx 2022 Feb 15;49(1):34-45. Epub 2021 Apr 15.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland.

Objectives: The purpose was to evaluate magnetic resonance imaging (MRI) classification of endolymphatic hydrops with clinical features, audiological and vestibular tests in patients with definite unilateral Ménière's disease (MD).

Methods: Thirty-eight patients were enrolled in this study. The severity of the main clinical symptoms, audiovestibular tests, and MRI, performed 4 hours after intravenous injection of gadobutrol to visualize inner ear compartments, were evaluated. Read More

View Article and Full-Text PDF
February 2022

Effectiveness of intratympanic dexamethasone for the treatment of vertigo attacks in patients with Ménière's disease compared with betahistine pharmacotherapy.

J Int Med Res 2021 Apr;49(4):300060520985647

37637Semmelweis University, Department of Otolaryngology and Head and Neck Surgery, Budapest, Hungary.

Objective: This study analyzed the possible effects of intratympanic steroid (ITS) therapy in the symptomatic treatment of vertigo attacks in patients with Ménière's disease.

Methods: Thirty-five patients treated with ITS (dexamethasone) plus betahistine (Group A) and 35 patients treated with betahistine alone (Group B) were enrolled in this investigation. Complaints were analyzed using medical records and vertigo diaries. Read More

View Article and Full-Text PDF

Comparison of inner ear MRI enhancement in patients with Meniere's disease after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Eur J Radiol 2021 Jun 26;139:109682. Epub 2021 Mar 26.

Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China. Electronic address:

Purpose: To compare the enhancement results of three gadolinium contrast agents in the inner ear of patients with Meniere's disease 4 h after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Methods: We enrolled 60 patients with a definitive diagnosis of unilateral Meniere's disease and divided them into three groups of 20 patients; each group received a double dose of gadobutrol, gadoterate meglumine, or gadodiamide. The postcontrast signal intensity of the basal cochlear turn was scored quantitatively, and qualitative visual evaluation of the cochlea, vestibule and semi-circular canals was also performed. Read More

View Article and Full-Text PDF

Evaluation of vestibular function following endolymphatic sac surgery.

Eur Arch Otorhinolaryngol 2022 Mar 19;279(3):1193-1201. Epub 2021 Mar 19.

Service d'ORL et de Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire de Nantes (CHU), Hôtel-Dieu, 1, Place A. Ricordeau, BP 1005, 44093, Nantes Cedex 01, France.

Purpose: To evaluate objective vestibular function after endolymphatic sac surgery (ELSS) for Menière's disease (MD), using comparative vestibular function tests: videonystagmography (VNG), vestibular evoked myogenic potentials (VEMP) and video head-impulse test (VHIT) METHODS: Patients with definite MD using the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) of 1995 criteria modified in 2015 and treated with ELSS (sac decompression or sac opening) were included. The primary outcome was the preservation of vestibular function, comparing pre- and postoperative vestibular function tests: VNG, VEMP, VHIT. Secondary outcomes were control of episodes of vertigo, hearing outcome using AAO-HNS criteria, and QoL using the Menière's disease outcome questionnaire. Read More

View Article and Full-Text PDF

[Various types of vertigo and balance disorders in patients with Meniere's disease].

Vestn Otorinolaringol 2021 ;86(1):90-95

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Vertigo and balance disorders in Meniere's disease (MD) may have various etiology. The aim of the review is discussing pathogenetic mechanisms of the typical vertiginous paroxysms in MD, resulting from endolymphatic hydrops as well as analysis of etiology, pathogenesis, clinical course and basic treatment of paroxysmal and permanent forms of vertigo and balance disorders, caused by other conditions, associated with MD. We discussed the course of MD complicated by vestibular migraine, benign positional paroxysmal vertigo, functional dizziness, bilateral vestibulopathy and vestibular drop-attacks. Read More

View Article and Full-Text PDF

Effects of Glucocorticoids on the Inner Ear.

Front Surg 2020 11;7:596383. Epub 2021 Jan 11.

Department of Otorhinolaryngology Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.

Recently, several lines of evidence have suggested that the inner ear is under hormonal control. It is likely that steroids have some influence on the inner ear. Many clinicians have been empirically using steroids for the treatment of diseases associated with endolymphatic hydrops. Read More

View Article and Full-Text PDF
January 2021