358 results match your criteria Inner Ear Meniere Disease Medical Treatment


Endolymphatic hydrops mimicking obstructive Eustachian tube dysfunction: preliminary experience and literature review.

Eur Arch Otorhinolaryngol 2020 Jun 24. Epub 2020 Jun 24.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.

Purpose: Aural fullness is a common symptom of middle ear diseases, most importantly Eustachian tube dysfunction (ETD). Yet, aural fullness may also be caused by inner ear disorders, such as hydropic ear diseases. Here, we report our experience with endolymphatic hydrops (EH) mimicking ETD. Read More

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http://dx.doi.org/10.1007/s00405-020-06139-9DOI Listing

Current status on researches of Meniere's disease: a review.

Acta Otolaryngol 2020 Jun 21:1-5. Epub 2020 Jun 21.

Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.

Meniere's disease (MD) is a complex and multifactorial inner ear disease. The etiology of MD is unclear. Significant progress had been made in diagnosis and treatment. Read More

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http://dx.doi.org/10.1080/00016489.2020.1776385DOI Listing

Clinical Practice Guideline: Ménière's Disease Executive Summary.

Otolaryngol Head Neck Surg 2020 04;162(4):415-434

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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http://dx.doi.org/10.1177/0194599820909439DOI Listing

Clinical Practice Guideline: Ménière's Disease.

Otolaryngol Head Neck Surg 2020 04;162(2_suppl):S1-S55

American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.

Objective: Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also presents with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear. The underlying etiology of MD is not completely clear, yet it has been associated with inner ear fluid (endolymph) volume increases, culminating in episodic ear symptoms (vertigo, fluctuating hearing loss, tinnitus, and aural fullness). Read More

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http://dx.doi.org/10.1177/0194599820909438DOI Listing

Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy.

Laryngoscope 2019 Nov 11. Epub 2019 Nov 11.

Department of Sense Organs and Ear, Nose, and Throat Department, Sapienza University of Rome, Rome, Italy.

Objectives/hypothesis: To evaluate the incidence of chronic cerebrospinal venous insufficiency in Menière's disease patients and the effect of bilateral percutaneous transluminal angioplasty of the jugular/azygos veins compared to medical therapy.

Study Design: Prospective case-control study.

Methods: Five hundred fourteen subjects were included in the study, 412 affected by definite Menière's disease, and 102 healthy controls. Read More

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http://dx.doi.org/10.1002/lary.28389DOI Listing
November 2019

Expression of aquaporins in inner ear disease.

Laryngoscope 2020 Jun 8;130(6):1532-1539. Epub 2019 Oct 8.

Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School, Kyung Hee University, Seoul, South Korea.

The inner ear is responsible for hearing and balance and consists of a membranous labyrinth within a bony labyrinth. The balance structure is divided into the otolith organ that recognizes linear acceleration and the semicircular canal that is responsible for rotational movement. The cochlea is the hearing organ. Read More

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http://dx.doi.org/10.1002/lary.28334DOI Listing
June 2020
3 Reads

Intraoperative Electrocochleography in Patients With Menière's Disease Undergoing Endolymphatic Sac Decompression and Shunt Surgery.

Otol Neurotol 2019 10;40(9):1208-1216

Department of Otolaryngology - Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Hypothesis: Objective physiologic changes measured using electrocochleography at the round window (ECOG) are observable during endolymphatic sac decompression and shunt surgery (ELS).

Background: Limited effective treatment options are available to patients with Menière's disease (MD) who have failed conservative management, experience persistent vertigo symptoms, and have substantial residual hearing. ELS is a feasible therapeutic option for these patients. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002345DOI Listing
October 2019
1 Read

Approach to Ménière disease management.

Can Fam Physician 2019 07;65(7):463-467

Otologist, neurotologist, and cranial base surgeon, Clinician Scientist, and Assistant Professor in the Department of Otolaryngology at Queen's University, and Adjunct Scientist at ICES Queen's.

Objective: To provide family physicians with an updated approach to the diagnosis and management of Ménière disease (MD), detailing the natural course of MD and describing how to initiate medical therapy while awaiting consultation with otolaryngology-head and neck surgery.

Sources Of Information: The approach is based on the authors' clinical practices and review articles from 1989 to 2018. Most of the cited studies provided level II or III evidence. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738466PMC
July 2019
5 Reads

Relationship between changes in hearing function and volumes of endolymphatic hydrops after endolymphatic sac drainage.

Acta Otolaryngol 2019 Sep 5;139(9):739-746. Epub 2019 Jul 5.

a Department of Otolaryngology - Head and Neck Surgery, Nara Medical University , Kashihara , Japan.

Endolymphatic sac drainage (ELSD) may have a positive effect on endolymphatic hydrops (EH) and may help to preserve inner ear function. However, the relationship between changes in EH volumes and hearing function after ELSD has not been described. We aimed to reveal the factors related to changes in hearing and EH following ELSD. Read More

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https://www.tandfonline.com/doi/full/10.1080/00016489.2019.1
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http://dx.doi.org/10.1080/00016489.2019.1630757DOI Listing
September 2019
2 Reads

[Vascular mechanisms in Meniere's disease].

Vestn Otorinolaringol 2019 ;84(2):70-77

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia, 117997

Meniere's disease (MD) is chronic multifactorial medical condition caused by endolymphatic hydrops, which etiology is unclear. This review highlights possible vascular mechanisms of MD. Impairment of vascular regulation, further ischemic damage of labyrinth and venous drainage pathology could lead to endolymphatic hydrops. Read More

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http://dx.doi.org/10.17116/otorino20198402170DOI Listing
August 2019
6 Reads

Magnetic resonance imaging of the endolymphatic space in patients with acute low-tone sensorineural hearing loss.

Auris Nasus Larynx 2019 Dec 7;46(6):859-865. Epub 2019 May 7.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan.

Objective: The aim of this study was to measure the volume of the endolymphatic space (ELS) and to investigate prognosis in patients with acute low-tone sensorineural hearing loss (ALHL).

Methods: A total of 61 ALHL patients participated; 47 were definite while 14 were probable ALHL cases. The definite ALHL patients were classified into three groups: A, "Cure"; B, "No cure"; and C, "Recurrence. Read More

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http://dx.doi.org/10.1016/j.anl.2019.04.003DOI Listing
December 2019
8 Reads

Therapeutic strategies in the treatment of Menière's disease: the Italian experience.

Eur Arch Otorhinolaryngol 2019 Jul 11;276(7):1943-1950. Epub 2019 Apr 11.

UOSD "Vestibologia E Otorinolaringoiatria" Presidio Ospedaliero "Giovanni Paolo II", Policoro, Italy.

Purpose: Ménière's disease (MD) is an inner ear disorder of unknown etiology, whose pathological substrate is the endolymphatic hydrops. Different treatments have been proposed; however, evidence of their effectiveness is lacking. The aim of this study was to evaluate by a questionnaire which medical and surgical treatments are used in Italy for the treatment of MD and to compare them with those proposed in other countries. Read More

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http://dx.doi.org/10.1007/s00405-019-05423-7DOI Listing
July 2019
15 Reads

Volume-rendered computed tomography images of the surgical field for endolymphatic sac surgery.

Eur Arch Otorhinolaryngol 2019 Jun 30;276(6):1617-1624. Epub 2019 Mar 30.

Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan.

Purpose: Identification of the endolymphatic sac has failed occasionally. Postoperative complications have also rarely been reported. Given a safer and more reliable surgery, preoperative anatomical assessments are valuable, however, the vestibular aqueduct has seldom been seen with multi-planar reconstruction (MPR) computed tomography (CT) images yet. Read More

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http://link.springer.com/10.1007/s00405-019-05399-4
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http://dx.doi.org/10.1007/s00405-019-05399-4DOI Listing
June 2019
20 Reads

CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière's disease.

Acta Otolaryngol 2019 Apr 25;139(4):336-339. Epub 2019 Mar 25.

d Department of Otolaryngology , Cathay General Hospital , Taipei , Taiwan.

Background: Ménière's disease (MD) is a disorder of the inner ear, causing episodes of vertigo. Although surgery is reserved for intractable MD, intratympanic gentamicin (ITG) injection has become an alternative for controlling vertigo.

Aims/objectives: To investigate the genetic basis of ITG efficacy. Read More

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http://dx.doi.org/10.1080/00016489.2019.1575525DOI Listing
April 2019
1 Read

[Analysis of clinical features of secondary benign paroxysmal positional vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Mar;33(3):220-224

Center of Vertigo Clinic Research of Aerospace, General Hospital of PLA Air Force, Beijing, 100142, China.

To analyze the clinical features of secondary benign paroxysmal positional vertigo (BPPV) and provide evidence for its precise diagnosis and treatment. There were 942 patients with vertigo related to BPPV, including 204 patients with primary BPPV, 592 patients with vestibular migraine (VM), 83 patients with Meniere's disease (MD), 48 patients with vestibular neuronitis (VN), and 15 patients with sudden sensorineural hearing loss (SSNHL) accompanied by vertigo.There were 127 patients with BPPV secondary to vertigo in MD, VN, VM, and SSNHL. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.03.009DOI Listing
March 2019
8 Reads

Three-Dimensional Magnetic Resonance Imaging Reveals the Relationship Between the Control of Vertigo and Decreases in Endolymphatic Hydrops After Endolymphatic Sac Drainage With Steroids for Meniere's Disease.

Front Neurol 2019 4;10:46. Epub 2019 Feb 4.

Department of Otolaryngology- Head and Neck Surgery, Nara Medical University, Kashihara, Japan.

Meniere's disease is a common disease, that presents with recurrent vertigo and cochlear symptoms. The pathology of Meniere's disease was first reported to involve endolymphatic hydrops in 1938. The endolymphatic sac is thought to have a role to keep the hydrostatic pressure and endolymph homeostasis for the inner ear. Read More

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http://dx.doi.org/10.3389/fneur.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369164PMC
February 2019
21 Reads

[The influence of corticosteroids on the frequency of vestibular crises].

Vestn Otorinolaringol 2018;83(6):27-30

Department of Diseases of Ear, Throat, and Nose, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia, 344022.

The objective of the present study was to elucidate the dynamics of the hormonal status of the adrenal glands in the patients suffering from Menière's disease in its different clinical forms. We examined a total of 26 patients at the age from 29 to 47 years presenting with this condition. All the patients were divided into two groups depending on the character of the disease. Read More

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http://www.mediasphera.ru/issues/vestnik-otorinolaringologii
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http://dx.doi.org/10.17116/otorino20188306127DOI Listing
June 2019
25 Reads

[Possible effect of diabetes and hypertension on the quality of life of patients suffering from Ménière's disease].

Orv Hetil 2019 Jan;160(4):144-150

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Semmelweis Egyetem Budapest, Szigony u. 36., 1083.

Introduction: Ménière's disease is a disorder of the inner ear, characterized by episodic rotational vertigo, sensorineural hearing loss, tinnitus, aural pressure and vegetative symptoms. Since the improvement of these symptoms exerts an influence on the patients' quality of life and the condition seems to be incurable, the symptomatic treatment suggests an important question.

Aim: Our study's aim is to evaluate how hypertension and diabetes exert influence on the patients' quality of life and how effective conservative pharmacologic treatment is. Read More

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http://dx.doi.org/10.1556/650.2019.31256DOI Listing
January 2019
12 Reads

Clinical features and management of Meniere's disease patients with drop attacks.

Eur Arch Otorhinolaryngol 2019 Mar 2;276(3):665-672. Epub 2019 Jan 2.

Department of Otology and Skull Base Surgery, Hearing Research Key Lab of Health Ministry of China, Eye and Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Purpose: The aims of the present study are to investigate the variations in clinical features, including medical history, hearing function, vestibular function, and degree of endolymphatic hydrops (EH), in Meniere's disease (MD) patients with and without drop attacks (DAs), and to examine the efficacy of intratympanic gentamicin (ITG) treatment in alleviating DAs.

Methods: In total, 177 unilateral definite MD patients, including 16 patients with DAs and 161 patients without DAs, were enrolled. The results of hearing test, vestibular-evoked myogenic potentials (VEMPs), and magnetic resonance imaging (MRI) were analyzed. Read More

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http://dx.doi.org/10.1007/s00405-018-5260-5DOI Listing
March 2019
5 Reads

Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI.

Auris Nasus Larynx 2019 Jun 27;46(3):335-345. Epub 2018 Nov 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This study was performed to determine whether endolymphatic sac surgery improves vestibular and cochlear endolymphatic hydrops 2 years after sac surgery and to elucidate the relationship between the degree of improvement of endolymphatic hydrops and the changes in vertigo symptoms, the hearing level, and the summating potential/action potential ratio (-SP/AP ratio) by electrocochleography (ECochG) in patients with Ménière's disease (MD).

Methods: Twenty-one patients with unilateral MD who underwent sac surgery were included in this study. All patients underwent gadolinium-enhanced magnetic resonance imaging (Gd-MRI) before and 2 years after sac surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183065
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http://dx.doi.org/10.1016/j.anl.2018.10.011DOI Listing
June 2019
52 Reads

Usefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Ménière's Disease.

Sci Rep 2018 12 3;8(1):17562. Epub 2018 Dec 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

This study aimed to investigate the usefulness of the intravenous gadolinium enhanced inner ear magnetic resonance imaging (IV-Gd inner ear MRI) in diagnosing Ménière's disease(MD) and find a correlation between the degree of endolymphatic hydrops(EH) and the audiovestibular tests. Total 29 patients diagnosed with unilateral definite MD were enrolled. All patients underwent IV-Gd inner ear MRI and auditory and vestibular function tests such as pure tone audiometry (PTA), electrocochleography (ECoG), cervical vestibular evoked myogenic potential (cVEMP) and caloric test. Read More

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http://dx.doi.org/10.1038/s41598-018-35709-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277445PMC
December 2018
12 Reads

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237362PMC
April 2019
41 Reads

[The effectiveness of the intra-tympanic administration of methylprednisolone and gentamycin for the treatment of Meniere's disease].

Vestn Otorinolaringol 2018;83(5):17-20

MSCh 'Neftyanik' joint stock company, Tyumen, Russia.

Meniere's disease is an inner ear pathology characterized by periodic fits of systemic dizziness, fluctuating low-frequency sensorineural loss of hearing, stuffiness in the ear and tympanophonia. The objective of the present study was to evaluate the effectiveness of the intra-tympanic administration of methyl prednisolone in the combination with gentamycin used to treat the patients presenting with Meniere's disease. The study included 18 patients at the age varying from 18 to 70 years presenting with this condition. Read More

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http://dx.doi.org/10.17116/otorino20188305117DOI Listing
June 2019
8 Reads

[Non-drug therapy of vertigo].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(8):38-42

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To study the efficacy of various methods of non-drug therapy of diseases manifested by vertigo and dizziness in neurological practice.

Material And Methods: Referral and final diagnoses were compared after neurovestibular examination of 599 patients (177 men and 422 women), aged 25 to 79 years (mean age 55 years), with various causes of vertigo. Patients underwent vestibular rehabilitation, trainings on the stabiloplatform with biological feedback (biofeedback), repositioning maneuvers in patients with benign paroxysmal positional vertigo (BPPV). Read More

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http://dx.doi.org/10.17116/jnevro201811808138DOI Listing
March 2019
13 Reads

Sequential Imaging in Patient With Suspected Menière's Disease Identifies Endolymphatic Sac Tumor.

Otol Neurotol 2018 10;39(9):e856-e859

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

Objective: The standard evaluation of patients with suspected Menière's disease (MD) includes initial imaging to rule out tumors of the temporal bone. Few guidelines, however, advocate sequential imaging. We propose that sequential imaging may reveal other etiologies of auditory and vestibular symptoms as demonstrated in a patient with an endolymphatic sac tumor that was originally diagnosed Menière's after initial imaging. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001952DOI Listing
October 2018
11 Reads

[Postoperative anxiety and its relationship with life quality in patients with Ménière's diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):662-667

Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital, Beijing 100123, China.

Objective: To investigate the postoperative anxiety and its relationship with life quality in patients with Ménière's diseases.
 Methods: A total of 68 patients with Ménière's disease, who received the treatment of endolymphatic sac decompression from 2010 to 2016, were enrolled. They finished two scales (the self-rating anxiety scale and the quality of life questionnaire for endolymphatic sac decompression of Ménière's disease) by snail mail. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.06.014DOI Listing
June 2018
20 Reads

Transcanal endoscopic infracochlear vestibular neurectomy: A pilot cadaveric study.

Am J Otolaryngol 2018 Nov - Dec;39(6):731-736. Epub 2018 Aug 1.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; University of Massachusetts Medical School, Worcester, MA, USA; Department of Otolaryngology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA, USA. Electronic address:

Purpose: Effective operative approaches for the treatment of refractory vertigo in Meniere's disease are invasive. Vestibular neurectomy can preserve hearing and has been shown to be effective; however, current approaches require an extensive craniotomy. Transcanal endoscopic approaches to the internal auditory canal (IAC) with cochlear preservation have been recently described and may offer a minimally invasive approach to selectively sectioning the distal vestibular nerves while preserving residual hearing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183047
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http://dx.doi.org/10.1016/j.amjoto.2018.07.024DOI Listing
February 2019
21 Reads

Ménière's disease with unremitting floating sensation is associated with canal paresis, gravity-sensitive dysfunction, mental illness, and bilaterality.

Auris Nasus Larynx 2019 Apr 30;46(2):186-192. Epub 2018 Jul 30.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan.

Objective: The aim of the present study was to evaluate the association of neuro-otological examination, blood tests, and scoring questionnaire data with treatment-resistant intractability of persistent dizziness in Ménière's disease.

Methods: We managed 1520 successive vertigo/dizziness patients at the Vertigo/Dizziness Center in Nara Medical University from May 2014 to April 2018. Five hundred and twenty-two patients were diagnosed with Ménière's disease (522/1520; 34. Read More

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http://dx.doi.org/10.1016/j.anl.2018.07.003DOI Listing
April 2019
94 Reads

[Bilateral vestibulopathy].

Authors:
R Huang G R Bi

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(24):1937-1939

Department of Neurology, Shengjing Hospital of China Medical University.

The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait, deficits of spatial memory and navigation. The etiology of BVP remains unclear in more than 50% of patients: in these cases neurodegeneration is assumed. Frequent known causes are ototoxicity mainly due to gentamicin, bilateral Menière's disease, autoimmune diseases, meningitis and bilateral vestibular schwannoma, as well as an association with cerebellar degeneration. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.24.018DOI Listing
December 2017
11 Reads

[Long-term results of endolymphatic sac mastoid drainage for Ménière disease].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):138-142

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education Beijing,100730,China.

To investigate the long-term efficacy of endolymphatic sac mastoid drainage for Ménière disease.Data from 26 patients diagnosed with MD strictly meeting the criteria issued by " Guideline of diagnosis and treatment of Meniere disease(2017)" from 2006 to 2015 were analyzed in this study.Endolymphatic sac mastoid shunt surgery was performed for each patient. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.02.015DOI Listing
January 2018
25 Reads

Endolymphatic Sac Decompression With Intra-Sac Dexamethasone Injection in Menière's Disease.

Otol Neurotol 2018 06;39(5):616-621

Wayne State University, Detroit.

Objective: Endolymphatic sac decompression surgery (ELSD) may be used to treat patients who have Menière's 's disease refractory to medical therapy. In this study, we investigated whether or not the injection of steroid into the endolymphatic sac at the time of ELSD provides additional benefit to patient outcomes.

Study Design: Randomized prospective single-blinded placebo-controlled study. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001810DOI Listing
June 2018
6 Reads

Effects of combined oral contraception containing drospirenone on premenstrual exacerbation of Meniere's disease: Preliminary study.

Eur J Obstet Gynecol Reprod Biol 2018 May 10;224:102-107. Epub 2018 Mar 10.

Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic, Research Group for Sexology, University of Catania, Via Santa Sofia 78, PC 95124, Catania, Italy.

Objectives: Meniere's disease is caused by an augmented endolymph pressure in the inner ear; symptoms are vertigo, fluctuating hearing loss and tinnitus. Exacerbations has been noted during premenstrual phase. The study aims to evaluate the effects of a 20 μm Ethinylestradiol (EE) and 3 mg Drospirenone (DRSP) oral contraceptive (20 μmEE/3mgDRSP) in continuous regimen, associated with rehabilitation therapy on Meniere's disease. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.03.015DOI Listing
May 2018
13 Reads

Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment.

Laryngoscope Investig Otolaryngol 2017 12 31;2(6):344-350. Epub 2017 Oct 31.

Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan.

Objective/hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Read More

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http://dx.doi.org/10.1002/lio2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743151PMC
December 2017
29 Reads

Signs of electrocochleography on endolymphatic sac decompression for patients with Ménière's Disease: Our experience in 12 patients.

Clin Otolaryngol 2018 06 25;43(3):920-923. Epub 2018 Mar 25.

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/coa.13047DOI Listing
June 2018
12 Reads

Mastoid and Inner Ear Measurements in Patients With Menière's Disease.

Otol Neurotol 2017 12;38(10):1484-1489

*Department of Otolaryngology-Head and Neck Surgery †Department of General Surgery, Detroit Medical Center, Michigan State University, Detroit ‡Department of Radiology, Michigan State University, East Lansing §Department of Otology, Neurotology, and Skull Base Surgery, Michigan Ear Institute, Farmington Hills, Michigan.

Objective: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls.

Study Design: Retrospective chart review.

Setting: Two tertiary referral centers. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001576DOI Listing
December 2017
16 Reads

Evaluation of endolymphatic hydrops using 3-T MRI after intravenous gadolinium injection.

Eur Arch Otorhinolaryngol 2017 Dec 25;274(12):4103-4111. Epub 2017 Sep 25.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.

Aim of this work is to establish evaluation criteria for identifying endolymphatic hydrops in the vestibule and cochlea using a magnetic resonance imaging (MRI) scanner. This is a retrospective diagnostic study. We evaluated 70 ears of 35 unilateral Ménière's disease patients. Read More

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http://dx.doi.org/10.1007/s00405-017-4739-9DOI Listing
December 2017
63 Reads

[Otogenic vertigo].

Authors:
Robert Gürkov

MMW Fortschr Med 2017 Sep;159(15):50-58

Klinik für Hals-Nasen-Ohrenheilkunde, Deutsches Schwindel- und Gleichgewichtszentrum, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-017-9591-8DOI Listing
September 2017
1 Read

Evidence of surgical treatments for intractable Meniere's disease.

Authors:
Tadashi Kitahara

Auris Nasus Larynx 2018 Jun 29;45(3):393-398. Epub 2017 Jul 29.

Department of Otolaryngology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, Japan. Electronic address:

Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. Read More

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http://dx.doi.org/10.1016/j.anl.2017.07.016DOI Listing
June 2018
8 Reads

Association between ambient particulate matter and disorders of vestibular function.

Environ Res 2017 05 10;155:242-248. Epub 2017 Mar 10.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, South Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

Background: Exposure to environmental chemicals has been suggested to alter the physiologic state of the inner and middle ear. However, it is unknown if particulate matter exposure is associated with acute vestibular dysfunction.

Objectives: To estimate the effects of particulate matter exposure on the number of hospital visits related to three major diseases of vestibular dysfunction, Meniere's disease (MD), benign paroxysmal positional vertigo (BPPV), and vestibular neuronitis (VN). Read More

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http://dx.doi.org/10.1016/j.envres.2017.02.013DOI Listing
May 2017
14 Reads
2 Citations
4.373 Impact Factor

Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Am J Otolaryngol 2017 May - Jun;38(3):285-290. Epub 2017 Jan 20.

Ear, Nose, and Throat Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Objectives: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration.

Study Design: Retrospective case series and patient survey.

Setting: Tertiary university hospital. Read More

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http://dx.doi.org/10.1016/j.amjoto.2017.01.023DOI Listing
April 2018
54 Reads

The Effect of Vestibular Rehabilitation in Patients with Ménière's Disease.

Otolaryngol Head Neck Surg 2017 03 14;156(3):426-434. Epub 2016 Nov 14.

2 Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Centre, The Netherlands.

Objective To systematically review the evidence on the effect of vestibular rehabilitation in patients with Ménière's disease (MD) on balance and dizziness-related quality of life. Data Sources A literature search was conducted in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Web of Science, and CINAHL databases. Review Methods Articles were reviewed by 2 independent authors and data were compiled in tables for analysis regarding balance (ie, posturography) and dizziness-specific quality of life in patients with MD. Read More

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http://dx.doi.org/10.1177/0194599816678386DOI Listing
March 2017
33 Reads

Intraoperative Electrocochleography: A Window Into Endolymphatic Hydrops in a Patient With an Endolymphatic Sac Tumor.

Otol Neurotol 2017 04;38(4):547-550

*Department of Otolaryngology, The Ohio State University Wexner Medical Center, Ohio †Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Objectives: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops.

Patients: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. Read More

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http://Insights.ovid.com/crossref?an=00129492-201704000-0001
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http://dx.doi.org/10.1097/MAO.0000000000001340DOI Listing
April 2017
42 Reads

Diagnostic and therapeutic strategy in Menière's disease. Guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (SFORL).

Eur Ann Otorhinolaryngol Head Neck Dis 2017 Dec 3;134(6):441-444. Epub 2017 Jan 3.

Inserm UMR 1107, service ORL, laboratoire de biophysique neurosensorielle, université d'Auvergne, CHU Gabriel-Montpied, Clermont-Ferrand, France. Electronic address:

Objectives: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou: SFORL) for diagnostic and therapeutic strategy in Menière's disease.

Methods: A work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, then read over by an editorial group independent of the work group. Read More

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http://dx.doi.org/10.1016/j.anorl.2016.12.003DOI Listing
December 2017
15 Reads

Intratympanic steroids injection is effective for the treatment of drop attacks with Ménière's disease and delayed endolymphatic hydrops: A retrospective study.

Medicine (Baltimore) 2016 Dec;95(52):e5767

Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, PR China.

Drop attack (DA) associated with Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is not common and may cause life-threatening clinical problems. The intratympanic dexamethasone (ITD) is one of primary treatments for MD or DEH. Our study investigated the effect of ITD on the DA associated with endolymphatic hydrops (EH). Read More

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http://dx.doi.org/10.1097/MD.0000000000005767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207592PMC
December 2016
15 Reads

Endolymphatic Duct Blockage for Refractory Ménière's Disease: Assessment of Endolymphatic Sac Biopsy on Short-Term Surgical Outcomes.

J Int Adv Otol 2016 Dec;12(3):310-315

Division of Otolaryngology-Head-Neck Surgery, University of Montreal Hospital Centre (CHUM), Montreal, QC, Canada.

Objective: Endolymphatic sac decompression (ESD) for the treatment of Ménière's disease (MD) has had limited success and variable results in the literature. We have devised a novel technique that involves blocking the endolymphatic duct with surgical clips. In a separate effort to study the endolymphatic sac (ELS), we have sectioned the lateral part of the main body of the ELS as biopsies from a subset of patients. Read More

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http://dx.doi.org/10.5152/iao.2016.3069DOI Listing
December 2016
52 Reads

Endolymphatic sac drainage for the treatment of Ménière's disease.

J Laryngol Otol 2017 Feb 15;131(2):144-149. Epub 2016 Dec 15.

Otorhinolaryngology Department,Faculty of Medicine,Hospital das Clínicas,University of São Paulo,Brazil.

Objective: To describe the results obtained with endolymphatic sac drainage in patients with Ménière's disease.

Method: A retrospective case review study was conducted of 95 Ménière's disease patients who underwent endolymphatic sac drainage in a tertiary care referral centre, after failing a long course of medical management. The main outcome measures were vertigo control and hearing preservation. Read More

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http://dx.doi.org/10.1017/S0022215116009713DOI Listing
February 2017
11 Reads

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015).

Expert Opin Ther Pat 2017 Feb 18;27(2):191-202. Epub 2016 Nov 18.

a Department of Chemistry , University of Southern California , Los Angeles , CA , USA.

Introduction: Inner ear disorders such as hearing loss, tinnitus, and Ménière's disease significantly impact the quality of life of affected individuals. Treatment of such disorders is an ongoing challenge. Current clinical approaches relieve symptoms but do not fully restore hearing, and the search for more effective therapeutic methods represents an area of urgent current interest. Read More

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http://dx.doi.org/10.1080/13543776.2017.1252751DOI Listing
February 2017
33 Reads

Changes in endolymphatic hydrops visualized by magnetic resonance imaging after sac surgery.

J Huazhong Univ Sci Technolog Med Sci 2016 Oct 18;36(5):736-740. Epub 2016 Oct 18.

Department of Otolaryngology & Head and Neck Surgery, Huazhong University of Science and Technology, Wuhan, 430030, China.

The purpose of the study was to observe changes in endolymphatic hydrops by using intratympanic injection of gadolinium and magnetic resonance imaging (MRI) before and after endolymphatic sac surgery in patients with unilateral Meniere's disease. Thirteen patients with unilateral Meniere's disease undergoing endolymphatic sac surgery were retrospectively and prospectively analyzed. Three-dimensional fluid-attenuated inversion recovery or three-dimensional real inversion recovery MRI was performed 24 h after an intratympanic injection of gadolinium to grade the presence of endolymphatic hydrops. Read More

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http://dx.doi.org/10.1007/s11596-016-1654-zDOI Listing
October 2016
49 Reads
0.780 Impact Factor

Meniett device in meniere disease: Randomized, double-blind, placebo-controlled multicenter trial.

Laryngoscope 2017 02 12;127(2):470-475. Epub 2016 Aug 12.

Department of Otology Auditory Implants and Skull Base Surgery, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.

Objective: To evaluate the efficacy of portable Meniett low-pressure pulse generator (Medtronic Xomed, Jacksonville, FL) in Meniere disease.

Study Design: Randomized, double-blind, placebo-controlled, multicenter trial carried out in 17 academic medical centers.

Methods: One hundred twenty-nine adults presenting Meniere disease (American Academy of Otolaryngology-Head and Neck Surgery criteria) not controlled by conventional medical treatment were included. Read More

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http://dx.doi.org/10.1002/lary.26197DOI Listing
February 2017
72 Reads

Incidence of Hypothyroidism in Meniere's Disease.

J Clin Diagn Res 2016 May 1;10(5):MC01-3. Epub 2016 May 1.

Post Graduate Student, Department of ENT, JJM Medical College , Davanagere, Karnataka, India .

Introduction: Meniere's disease is a disorder of the membranous labyrinth of the inner ear manifesting as vertigo, tinnitus, sensory neural hearing loss and aural fullness of known or unknown origin. Some patients may present after years into typical forms. The endocrine disorders, especially hypothyroidism and the factors like inflammation, trauma, otosclerosis, autoimmunity explains the multifactorial causation for the basis of Meniere's disease. Read More

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http://dx.doi.org/10.7860/JCDR/2016/17587.7759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948427PMC
May 2016
10 Reads