Cell Host Microbe 2019 Apr 21;25(4):513-525.e6. Epub 2019 Mar 21.
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea; Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:
In the inner ear, endolymph fluid surrounds the organ of Corti, which is important for auditory function; notably, even slight environmental changes mediated by trauma or infection can have significant consequences. However, it is unclear how the immune response is modulated in these tissues. Here, we report the local immune surveillance role of cleaved cochlin LCCL (Limulus factor C, Cochlin, and Lgl1) during Pseudomonas aeruginosa infection in the cochlea. Read More