495 results match your criteria Inner Ear Labyrinthitis


Cochlear implant in Thalassemia patient - Case report.

Cochlear Implants Int 2019 Jan 20;20(1):47-50. Epub 2018 Sep 20.

a Department of Otorhinolaryngology , SMS Medical College and Hospitals , Jaipur , India.

Introduction: Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin. Iron overload occurs in thalassemia, with blood transfusion therapy being the major cause. Deferoxamine continues to be the mainstay of therapy to remove excess iron in patients requiring long-term transfusions. Read More

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http://dx.doi.org/10.1080/14670100.2018.1522715DOI Listing
January 2019
2 Reads

Postoperative MR imaging features after superior semicircular canal plugging in Minor syndrome.

Diagn Interv Imaging 2018 Nov 13;99(11):679-687. Epub 2018 Sep 13.

Department of Neuroradiology, Lariboisière University Hospital, 75010 Paris, France. Electronic address:

Purpose: To report the postoperative magnetic resonance imaging (MRI) features after superior semicircular canal plugging in patients with Minor syndrome.

Materials And Methods: The MRI examinations with 3D T2-weighted SPACE sequence of 12 patients with superior semicircular canal dehiscence syndrome (SCDS) were retrospectively assessed. Two radiologists independently evaluated the presence of a filling defect of the superior semicircular canal above the superior ampulla and the common crus using an oblique plane parallel to the superior semicircular canal (Pöschl's plane). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183019
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http://dx.doi.org/10.1016/j.diii.2018.08.008DOI Listing
November 2018
9 Reads

Cochlear implantation in children with meningitis related deafness: The influence of electrode impedance and implant charge on auditory performance - A case control study.

Int J Pediatr Otorhinolaryngol 2018 Oct 24;113:102-109. Epub 2018 Jul 24.

Department of Otorhinolaryngology, Hannover Medical University, Carl-Neuberg-Straße 1, 30625, Hannover, Germany; German Hearing Center, Hannover Medical University, Karl-Wiechert-Allee 3, 30625, Hannover, Germany.

Objectives: Bacterial meningitis can cause a labyrinthitis. Consequences often are intracochlear soft tissue neoformation (cochlear obliteration) or intracochlear osteoneogenesis (cochlear ossification) and deafness. Cochlear implantation becomes challenging and hearing rehabilitation is complicated. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.07.034DOI Listing
October 2018
7 Reads

Epidemiology of Vestibular Impairments in a Pediatric Population.

Semin Hear 2018 Aug 20;39(3):229-242. Epub 2018 Jul 20.

Center for Evaluation of Balance Disorders in Children (EFEE), Robert Debré University Hospital, Paris, France.

The purpose of this study was to report the prevalence of vestibular impairment (VI) in children (  = 2,528) referred for complete vestibular testing because of balance disorders (BD) or hearing loss (H). A VI was shown in 51.5% of the children tested (1,304/2,528). Read More

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http://dx.doi.org/10.1055/s-0038-1666815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054584PMC
August 2018
4 Reads

Spontaneous Labyrinthine Hemorrhage: A Case Series.

Otolaryngol Head Neck Surg 2018 Nov 3;159(5):908-913. Epub 2018 Jul 3.

2 Department of Radiology, Emory University, Atlanta, Georgia, USA.

Objectives: To describe patient characteristics, audiometric outcomes, and magnetic resonance imaging (MRI) signal patterns in patients with suspected labyrinthine hemorrhage.

Study Design: Retrospective review.

Setting: Tertiary medical center. Read More

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http://dx.doi.org/10.1177/0194599818785900DOI Listing
November 2018
1 Read

Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog.

Acta Vet Scand 2018 May 22;60(1):31. Epub 2018 May 22.

Department of Diagnostic Medicine/Pathobiology, Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, K-221 Mosier Hall, Manhattan, KS, 66506-5802, USA.

Background: An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis and perineuritis in a dog with chronic otitis, bilateral tympanokeratomas and presumed extension of otic infection to the central nervous system. Read More

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http://dx.doi.org/10.1186/s13028-018-0386-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964671PMC
May 2018
4 Reads

Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis).

Comp Med 2018 Apr 12. Epub 2018 Apr 12.

Labyrinthitis is inflammation of the membranous and bony labyrinth of the inner ear. Typical portals of entry includehematogenous spread from the cochlear vasculature, passage of otitis media pathogens through the round window, and mostcommonly, meningogenic spread from the subarachnoid space. The sequela of chronic inner ear inflammation is labyrinthitisossificans, in which inner ear structures are replaced by fibrous and osseous tissues. Read More

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http://www.ingentaconnect.com/content/10.30802/AALAS-CM-17-0
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http://dx.doi.org/10.30802/AALAS-CM-17-000070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008717PMC
April 2018
18 Reads

Current diagnostic procedures for diagnosing vertigo and dizziness.

GMS Curr Top Otorhinolaryngol Head Neck Surg 2017 18;16:Doc02. Epub 2017 Dec 18.

HNO-Gemeinschaftspraxis, Main-Taunus-Zentrum, Sulzbach, Germany.

Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e. Read More

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http://dx.doi.org/10.3205/cto000141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738933PMC
December 2017
11 Reads

Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging.

PLoS One 2017 4;12(10):e0186038. Epub 2017 Oct 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.

Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627945PMC
November 2017
15 Reads

Our experience with 500 patients with benign paroxysmal positional vertigo: Reexploring aetiology and reevaluating MRI investigation.

Auris Nasus Larynx 2018 Apr 22;45(2):248-253. Epub 2017 Sep 22.

Department of Otorhinolaryngology and Head and Neck Surgery, Beaumont Hospital and Blackrock Clinic, Dublin, Ireland.

Objective: To explore the aetiology of and to evaluate the importance of MRI investigation on the posterior semicircular canal benign paroxysmal positional vertigo in an Irish population.

Methods: A retrospective observational study of 500 patients with posterior semicircular canal benign paroxysmal positional vertigo, diagnosed and treated by the senior author over a 10-year period. Most patients underwent an MRI brain and inner ear, following the same scan protocol. Read More

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http://dx.doi.org/10.1016/j.anl.2017.05.017DOI Listing
April 2018
4 Reads

Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation.

Audiol Neurootol 2017 24;22(2):116-123. Epub 2017 Aug 24.

Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Read More

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http://dx.doi.org/10.1159/000477534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730879PMC
August 2018
6 Reads

Characteristic MR findings suggesting presumed labyrinthine hemorrhage.

Acta Otolaryngol 2017 Dec 21;137(12):1226-1232. Epub 2017 Aug 21.

c Department of Otolaryngology-Head and Neck Surgery , Hanyang University Guri Hospital , Guri , Korea.

Objectives: To evaluate the magnetic resonance imaging (MRI) findings of labyrinthine hemorrhage as a cause of sudden sensorineural hearing loss (SSNHL).

Methods: MRI scans of 59 patients with SSNHL were retrospectively analyzed and compared to clinical features and audiometry data. MR images included pre-enhanced T1-weighted, 3D FLAIR volume isometric turbo spin-echo acquisition (VISTA), post-enhanced T1-weighted and 4-h-delayed enhanced FLAIR VISTA, and 3D thin-section proton density-weighted images. Read More

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http://dx.doi.org/10.1080/00016489.2017.1363911DOI Listing
December 2017
52 Reads

Bilateral Labyrinthine and Internal Auditory Canal Enhancement in an Infant With Severe Labyrinthine Dysplasia: A Previously Unreported Phenomenon.

Otol Neurotol 2017 06;38(5):e21-e25

*Department of Otorhinolaryngology †Department of Radiology ‡Department of Clinical Genomics §Department of Audiology, Mayo Clinic, Rochester, Minnesota.

Objective: To describe a novel case of congenital profound bilateral sensorineural hearing loss in a patient with bilateral nodular internal auditory canal and labyrinthine enhancement and temporal bone dysplasia.

Patients: A 76-day-old female was referred to the authors' center for evaluation of congenital deafness. Behavioral observations and objective audiometric evaluation demonstrated bilateral profound sensorineural hearing loss and a comprehensive multidisciplinary evaluation identified compound heterozygous pathogenic variants in MYO7A, a gene associated with Usher Syndrome Type 1B or DFNB2. Read More

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http://dx.doi.org/10.1097/MAO.0000000000001392DOI Listing
June 2017
13 Reads

[The role of computer and magnetic resonance imaging in patients with deafness].

Vestn Otorinolaringol 2016;81(6):13-16

City Children's Clinical Hospital of St. Vladimir, Moscow, Russia, 107140.

The objective of the present study was to evaluate the potential of CT and MRI for diagnostics of congenital and acquired pathology of the inner ear in the deaf patients. Two groups of the patients were examined. The first group consisted of 75 patients with congenital or acquired deafness etiology. Read More

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http://dx.doi.org/10.17116/otorino201681613-16DOI Listing
June 2017
3 Reads

Improvement in imaging common temporal bone pathologies at 3 T MRI: small structures benefit from a small field of view.

Clin Radiol 2017 Mar 26;72(3):267.e1-267.e12. Epub 2016 Dec 26.

University Department of Otolaryngology, Head and Neck Surgery, Eberhard-Karls-University Tübingen, Germany.

Aim: To compare image quality and evaluate its clinical importance in common temporal bone pathologies of a pTX-SPACE (parallel transmit [pTX] three-dimensional turbo spin-echo with variable flip angle [SPACE]) magnetic resonance imaging (MRI) sequence improved for spatial resolution to a standard-SPACE sequence exhibiting the same scan time at 3 T.

Materials And Methods: Thirty-four patients were examined using a standard-SPACE and resolution improved pTX-SPACE sequence at 3 T MRI. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and image quality were assessed. Read More

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http://dx.doi.org/10.1016/j.crad.2016.11.019DOI Listing
March 2017
4 Reads

Deterioration of Vestibular Cells in Labyrinthitis.

Ann Otol Rhinol Laryngol 2017 Feb 24;126(2):89-95. Epub 2016 Nov 24.

1 Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.

Objective: To quantitatively assess the effect of serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans on vestibular hair cells, dark cells, and transitional cells.

Methods: We examined human temporal bone specimens with serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans, then compared them with age-matched control groups without labyrinthitis. We evaluated the density of type I and II vestibular hair cells, dark cells, and transitional cells in the peripheral sensorial organs. Read More

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http://dx.doi.org/10.1177/0003489416675356DOI Listing
February 2017
14 Reads

Hearing Preservation After Penetrating Cochlear Injury.

Ann Otol Rhinol Laryngol 2017 Feb 19;126(2):163-165. Epub 2016 Nov 19.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.

Objectives: To share results and recommendations for management of penetrating cochlear injury.

Methods: A patient underwent repair of a penetrating cochlear injury after a projectile led to a traumatic cochleostomy with a narrow miss of the facial nerve and intracranial carotid artery.

Results: Postoperatively, the patient's audiogram demonstrated a pure tone average of 47. Read More

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http://dx.doi.org/10.1177/0003489416676186DOI Listing
February 2017
2 Reads

Otologic disorders causing dizziness, including surgery for vestibular disorders.

Handb Clin Neurol 2016 ;137:279-93

Department of Oto-Rhino-Laryngology, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France.

This chapter will focus on vertigo/dizziness due to inner-ear malformations, labyrinthine fistula, otosclerosis, infectious processes, and autoimmune inner-ear disorders. Inner-ear malformation due to dehiscence of the superior semicircular canal is the most recently described inner-ear malformation. Vertigo/dizziness is typically induced by sound and pressure stimuli and can be associated with auditory symptoms (conductive or mixed hearing loss). Read More

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http://dx.doi.org/10.1016/B978-0-444-63437-5.00020-0DOI Listing
February 2017
3 Reads

[The reclassification of sudden deafness].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Jul;30(14):1127-1130

Department of Otolaryngology,People's Hospital Peking University,Beijing,100044,China.

Reclassified the total deafness and flat type of sudden deafness,identified the relationship between new classification and hearing prognosis.To analyze 192 cases of patients with sudden deafness,especially for 159 cases of flat type and total deafness patients for further curve type classification,classified as rise,decline and consistent,analysis the possible factors with hearing in multiple factors using regression analysis.According to age group of 45 years old,>0. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2016.14.009DOI Listing

Hydrops of the organ of Corti.

Acta Otolaryngol 2016 Nov 31;136(11):1193-1195. Epub 2016 May 31.

a Department of Otorhinolaryngology , Showa University , Tokyo , Japan.

Objectives: The authors would like to confirm a fluid pathway from the scala tympani to the organ of Corti, and to observe its morphological changes.

Methods: A staining solution for succinic dehydrogenase was perfused with phenazine methosulfate in the scala tympani of living guinea pigs (n = 5) under deep anesthesia. After fixation, the cochleas were eventually embedded in epon. Read More

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http://dx.doi.org/10.1080/00016489.2016.1185541DOI Listing
November 2016
5 Reads

Indications and radiological findings of acute otitis media and its complications.

Acta Otorrinolaringol Esp 2017 Jan - Feb;68(1):29-37. Epub 2016 May 27.

Sección de Neurorradiología y Radiología de cabeza-cuello, Área Clínica de Imagen Médica, Hospital Universitario y Politécnico La Fe, Valencia, España.

Most cases of acute otitis media resolve with antibiotics and imaging is not required. When treatment fails or a complication is suspected, imaging plays a crucial role. Since the introduction of antibiotic treatment, the complication rate has decreased dramatically. Read More

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http://dx.doi.org/10.1016/j.otorri.2016.02.012DOI Listing
February 2018
1 Read

Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane.

Otolaryngol Head Neck Surg 2016 10 24;155(4):635-40. Epub 2016 May 24.

Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA

Objective: To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO).

Study Design: Comparative human temporal bone study.

Setting: Tertiary academic medical center. Read More

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http://dx.doi.org/10.1177/0194599816651245DOI Listing
October 2016
10 Reads

Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media.

Acta Otolaryngol 2016 Oct 16;136(10):1011-6. Epub 2016 May 16.

a Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Conclusion: Significant expression of macrophage migration inhibitory factor and its receptor (CD74) was observed in both the middle ear and inner ear in experimental otitis media in mice. Modulation of macrophage migration inhibitory factor and its signaling pathway might be useful in the management of inner ear inflammation due to otitis media.

Objectives: Inner ear dysfunction secondary to otitis media has been reported. Read More

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http://dx.doi.org/10.1080/00016489.2016.1179786DOI Listing
October 2016
6 Reads

Pneumolabyrinth with Labyrinthitis as the Suspected Cause.

Adv Otorhinolaryngol 2016 26;77:23-6. Epub 2016 Apr 26.

Pneumolabyrinth is a rare condition with air bubbles existing in the vestibule and/or cochlea. We report a case of pneumolabyrinth without trauma that was suspected to be caused by labyrinthitis. A 65-year-old man presented with vertigo and hearing loss in the left ear after catching a cold. Read More

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http://dx.doi.org/10.1159/000441866DOI Listing
February 2017
6 Reads

An approach to vertigo in general practice.

Aust Fam Physician 2016 Apr;45(4):190-4

Background: Dizziness is a common and very distressing presentation in general practice. In more than half of these cases, the dizziness is due to vertigo, which is the illusion of movement of the body or its surroundings. It can have central or peripheral causes, and determining the cause can be difficult. Read More

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April 2016
8 Reads

Quantitative Assessment of Cochlear Histopathologic Findings in Patients With Suppurative Labyrinthitis.

JAMA Otolaryngol Head Neck Surg 2016 Apr;142(4):364-9

Department of Otolaryngology, University of Minnesota, Minneapolis.

Importance: Better understanding of the effects of suppurative labyrinthitis (SL) on cochlear elements will aid the development of new approaches to treat its sequelae and complications in the ear.

Objective: To quantitatively evaluate the effects of SL on cochlear elements in humans.

Design, Setting, And Participants: A comparative study was conducted at a tertiary academic medical center from October 20, 2014, to January 3, 2015, of the histopathologic characteristics of 28 archived human temporal bone samples from 19 deceased patients with SL and 20 temporal bone samples from 14 deceased, age-matched controls. Read More

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http://dx.doi.org/10.1001/jamaoto.2015.3803DOI Listing
April 2016
11 Reads

Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study.

Am J Otolaryngol 2016 Mar-Apr;37(2):83-8. Epub 2015 Oct 8.

Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Purpose: To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis.

Materials And Methods: We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis.

Results: The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P=0. Read More

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http://dx.doi.org/10.1016/j.amjoto.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785270PMC
December 2016
8 Reads

Nystagmus in patients with unilateral acute otitis media complicated by serous labyrinthitis.

Acta Otolaryngol 2016 Jun 21;136(6):559-63. Epub 2016 Jan 21.

a Department of Otorhinolaryngology-Head and Neck Surgery , Konkuk University Medical Center, Konkuk University School of Medicine , Seoul , Republic of Korea.

Conclusion The patients with serous labyrinthitis caused by acute otitis media (AOM) exhibited various patterns of nystagmus in which direction-fixed irritative-type nystagmus was the most common pattern. Differential effects on inner ear function by toxic or inflammatory mediators may be responsible for the various manifestation of nystagmus. Objective This study aimed to investigate nystagmus patterns in patients with serous labyrinthitis, and discuss possible mechanisms. Read More

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http://dx.doi.org/10.3109/00016489.2015.1132845DOI Listing
June 2016
5 Reads

Differences in perilymphatic space enhancement and adverse inflammatory reaction after intratympanic injection of two different gadolinium agents: A 9.4-T magnetic resonance imaging study.

Hear Res 2016 Mar 13;333:118-126. Epub 2016 Jan 13.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea. Electronic address:

Purpose: To compare the inner ear enhancement after intratympanic injection of two widely used gadolinium (Gd) agents by 9.4 T micro-magnetic resonance imaging (MRI) and to investigate the effects of Gd on the inner ear.

Methods: Twelve ears of six rats received intratympanic administration of 1/5 diluted Gd agents: gadoterate meglumine (Gd-DTPA) for the left ear and gadodiamide (Gd-DTPA-BMA) for the right ear. Read More

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http://dx.doi.org/10.1016/j.heares.2015.10.022DOI Listing
March 2016
8 Reads
2.970 Impact Factor

Suppurative labyrinthitis associated with otitis media: 26 years' experience.

Braz J Otorhinolaryngol 2016 Jan-Feb;82(1):82-7. Epub 2015 Dec 11.

Department of Otorhinolaryngology, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil; Department of Head and Neck Surgery, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil.

Introduction: Suppurative labyrinthitis continues to result in significant hearing impairment, despite scientific efforts to improve not only its diagnosis but also its treatment. The definitive diagnosis depends on imaging of the inner ear, but it is usually clinically presumed.

Objective: To analyze the clinical factors and hearing outcomes in patients with labyrinthitis secondary to middle ear infections and to discuss findings based on imaging test results. Read More

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http://dx.doi.org/10.1016/j.bjorl.2014.12.012DOI Listing
August 2016
3 Reads

Prevention of trauma-induced cochlear fibrosis using intracochlear application of anti-inflammatory and antiproliferative drugs.

Neuroscience 2016 Mar 21;316:261-78. Epub 2015 Dec 21.

INSERM - UMR 1051, Institute for Neurosciences of Montpellier, Montpellier, France; University Montpellier 1 & 2, Montpellier, France; ENT Department, University Hospital Gui de Chauliac, Montpellier, France. Electronic address:

Cochlear fibrosis is a common finding following cochlear implantation. Evidence suggests that cochlear fibrosis could be triggered by inflammation and epithelial-to-mesenchymal cell transition (EMT). In this study, we investigate the mechanisms of cochlear fibrosis and the risk/benefit ratio of local administration of the anti-inflammatory drug dexamethasone (DEX) and antimitotic drug aracytine (Ara-C). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2015.12.031DOI Listing
March 2016
2 Reads

Effects of Intralabyrinthine Hemorrhage on the Cochlear Elements: A Human Temporal Bone Study.

Otol Neurotol 2016 Feb;37(2):132-6

*Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A. †Gebze Fatih State Hospital, Otolaryngology Division, Gebze, Kocaeli, Turkey ‡Giresun A. Ilhan Ozdemir State Hospital, Otolaryngology Division, Giresun, Turkey §Paparella Ear Head and Neck Institute, Minneapolis, Minnesota, U.S.A.

Hypothesis: To compare histopathologic findings in the cochlea of human temporal bones with versus without intralabyrinthine hemorrhage.

Background: Hemorrhagic labyrinthitis can cause sensorineural damage, sudden hearing loss, and vertigo. Yet, to our knowledge, no studies have quantitatively described histopathologic effects of intralabyrinthine hemorrhage on the elements of the cochlea. Read More

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http://dx.doi.org/10.1097/MAO.0000000000000927DOI Listing
February 2016
1 Read

Labyrinthine sequestration secondary to auditory implantation: report of two cases and review of the literature.

J Laryngol Otol 2015 Dec;129(12):1238-42

St Thomas' Hearing Implant Centre,St Thomas' Hospital,Guy's and St Thomas' NHS Foundation Trust,London,UK.

Background: Auditory implantation into the inner ear is increasingly performed for a variety of indications. Infective complications are rare, but when they occur they can have devastating consequences.

Case Reports: This paper reports two cases where vestibular sequestration of the bony labyrinth developed following implantation into the middle ear. Read More

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http://dx.doi.org/10.1017/S0022215115002455DOI Listing
December 2015
3 Reads

Predicting depth of electrode insertion by cochlear measurements on computed tomography scans.

Laryngoscope 2016 07 4;126(7):1656-61. Epub 2015 Nov 4.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.

Objectives/hypothesis: To evaluate the effectiveness of cochlear measures obtained by high-resolution computed tomography (HRCT) scan in predicting depth of cochlear implant insertion.

Study Design: Retrospective case review.

Methods: Patients who underwent cochlear implantation in an academic referral center between 2010 and 2013 were considered. Read More

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http://doi.wiley.com/10.1002/lary.25742
Publisher Site
http://dx.doi.org/10.1002/lary.25742DOI Listing
July 2016
5 Reads

The effect of intra-tympanic dexamethasone on the vestibular function in patients with recurrent vertigo.

Acta Otolaryngol 2015 6;135(12):1253-8. Epub 2015 Aug 6.

a 1 Department of Otorhinolaryngology, Clínica Universidad de Navarra , Pamplona, Spain.

Conclusion: The low clinical efficacy of the treatment for patients included in this work correlates with no noticeable effect on the vestibular function.

Objective: To assess follow-up in patients with idiopathic and secondary Ménière's disease after treatment with intra-tympanic dexamethasone and correlate clinical findings with changes in the vestibular-ocular reflex elicited after stimulation of each of the six semicircular canals.

Methods: This is a single center retrospective review of patients presenting the clinical symptomatology of Meniérè's disease treated with intra-tympanic dexamethasone. Read More

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http://dx.doi.org/10.3109/00016489.2015.1073355DOI Listing
August 2016
13 Reads

[Menière's Disease].

Laryngorhinootologie 2015 Aug 4;94(8):530-54. Epub 2015 Aug 4.

Menière`s disease is one of the most common inner ear and vestibular disorders. It is defined as the idiopathic syndrome of endolymphatic hydrops (ELH). Despite the development of several different animal models of ELH, its etiology and pathogenesis is still unresolved. Read More

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http://dx.doi.org/10.1055/s-0035-1555808DOI Listing
August 2015
6 Reads

Refractory Positional Vertigo With Apogeotropic Horizontal Nystagmus After Labyrinthitis: Surgical Treatment and Identification of Dysmorphic Ampullae.

Otol Neurotol 2015 Sep;36(8):1417-20

*Division of Otology-Neurotology, Department of Otolaryngology-Head and Neck Surgery; †Department of Pathology; and ‡Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, U.S.A.

Objectives: To describe the rationale, intraoperative details, and histopathologic findings discovered when treating an unusual case of apogeotropic horizontal canal positional vertigo with a transmastoid labyrinthectomy.

Patient: A single case report.

Intervention: Therapeutic. Read More

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http://dx.doi.org/10.1097/MAO.0000000000000820DOI Listing
September 2015
5 Reads
1 Citation
1.600 Impact Factor

Cochlear implantation in children with single-sided deafness: does aetiology and duration of deafness matter?

Audiol Neurootol 2015 19;20 Suppl 1:21-30. Epub 2015 May 19.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Freiburg, Freiburg, Germany.

For adult patients with single-sided deafness (SSD), treatment with a cochlear implant (CI) is well established as an acceptable and beneficial hearing rehabilitation method administered routinely in clinical practice. In contrast, for children with SSD, CI has been applied less often to date, with the rationale to decide either on a case-by-case basis or under the realm of clinical research. The aim of our clinical study was to evaluate the longitudinal benefits of CI for a group of children diagnosed with SSD and to compare their outcomes with respect to patient characteristics. Read More

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http://dx.doi.org/10.1159/000380744DOI Listing
March 2016
7 Reads

IL-10/HMOX1 signaling modulates cochlear inflammation via negative regulation of MCP-1/CCL2 expression in cochlear fibrocytes.

J Immunol 2015 Apr 16;194(8):3953-61. Epub 2015 Mar 16.

Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095;

Cochlear inflammatory diseases, such as tympanogenic labyrinthitis, are associated with acquired sensorineural hearing loss. Although otitis media is extremely frequent in children, tympanogenic labyrinthitis is not commonly observed, which suggests the existence of a potent anti-inflammatory mechanism modulating cochlear inflammation. In this study, we aimed to determine the molecular mechanism involved in cochlear protection from inflammation-mediated tissue damage, focusing on IL-10 and hemoxygenase-1 (HMOX1) signaling. Read More

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http://www.jimmunol.org/content/early/2015/03/14/jimmunol.14
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1402751
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http://dx.doi.org/10.4049/jimmunol.1402751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390512PMC
April 2015
6 Reads

Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling.

Ann Otol Rhinol Laryngol 2015 Aug 10;124(8):649-54. Epub 2015 Mar 10.

Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark.

Introduction: It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule. Read More

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http://dx.doi.org/10.1177/0003489415573960DOI Listing
August 2015
8 Reads

Progression of autoimmune inner ear disease to labyrinthitis ossificans: clinical and radiologic correlation.

Ear Nose Throat J 2015 Mar;94(3):108-10

Department of Diagnostic Radiology, Changi General Hospital, 2 Simei St. 3, Singapore 529889.

We report the case of a 42-year-old man who presented with fluctuating bilateral sensorineural hearing loss that subsequently progressed to a complete hearing loss, and we describe the correlation between the clinical and radiologic features of this case. To the best of our knowledge, this is the first report to demonstrate imaging evidence of progression from autoimmune inner ear disease to labyrinthitis ossificans. This is also the first reported case of a reversal of a loss of labyrinthine CISS (constructive interference in a steady state) signal, suggesting that T2-weighted hyposignal may be attributable to an alteration in labyrinthine fluid content and not to fibrosis only. Read More

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March 2015
8 Reads

[Visible defect in hearing loss and vestibular symptoms].

Laryngorhinootologie 2015 Jan;94(1):6-7

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January 2015
1 Read

Lyme disease: sudden hearing loss as the sole presentation.

J Laryngol Otol 2015 Feb 26;129(2):183-6. Epub 2015 Jan 26.

ENT Department,CUF Descobertas Hospital,Lisbon,Portugal.

Background: Lyme disease is an uncommon tick-borne multisystemic infection caused by Borrelia burgdorferi. The most common clinical manifestation is erythema migrans. In this report, a very unusual presentation of this condition is described, in which sudden onset sensorineural hearing loss was the sole presenting symptom. Read More

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http://www.journals.cambridge.org/abstract_S0022215114003417
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http://dx.doi.org/10.1017/S0022215114003417DOI Listing
February 2015
17 Reads

Imaging diagnostics: congenital malformations and acquired lesions of the inner ear.

Acta Otorrinolaringol Esp 2015 Jul-Aug;66(4):224-33. Epub 2014 Oct 12.

Sección de Neurorradiología y Radiología Cabeza-Cuello, Servicio de Radiología Hospital Universitario y Politécnico La Fe, Valencia, España.

Introduction: Congenital malformations and acquired lesions of the inner ear are characterised by small structural changes in this region. In recent decades, treatment options have improved considerably. At the same time, there has been a great advancement in diagnostic methods, obtaining high-resolution labyrinth images. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00016519140016
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http://dx.doi.org/10.1016/j.otorri.2014.07.002DOI Listing
March 2017
10 Reads

Preoperative imaging of sensorineural hearing loss in pediatric candidates for cochlear implantation.

Radiographics 2014 Sep-Oct;34(5):E133-49

From the Department of Radiology (J.Y.Y., M.E.R.) and Department of Otolaryngology- Head and Neck Surgery (N.M.Y.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Medical Imaging (J.Y.Y., M.E.R.) and Division of Pediatric Otolaryngology (N.M.Y.), Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60611; and Knowles Hearing Center, School of Communication, Northwestern University, Evanston, Ill (N.M.Y.).

Cochlear implantation is the only U.S. Food and Drug Administration-approved treatment for children with marked bilateral sensorineural hearing loss. Read More

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http://dx.doi.org/10.1148/rg.345130083DOI Listing
November 2015
6 Reads

Bilateral sensorineural hearing loss and labyrinthitis ossificans secondary to neurosarcoidosis.

Cochlear Implants Int 2014 Nov 5;15(6):337-40. Epub 2014 Sep 5.

Objective: To report a case of cochlear ossification as a result of neurosarcoidosis in a patient with bilateral profound sensorineural hearing loss.

Study Design: Case report: Setting University teaching hospital, tertiary referral center.

Patient: Forty-year-old man with neurosarcoidosis and bilateral profound sensorineural hearing loss. Read More

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http://dx.doi.org/10.1179/1754762814Y.0000000073DOI Listing
November 2014
14 Reads

The incidence of tympanogenic labyrinthitis ossificans.

J Laryngol Otol 2014 Jul;128(7):618-20

Department of Otolaryngology-Head and Neck Surgery,Mackay Memorial Hospital Taipei Branch,New Taipei City,Taiwan.

Objective: To estimate the incidence of tympanogenic labyrinthitis ossificans.

Methods: The records of patients treated with mastoidectomy for various tympanogenic aetiologies from January 2007 to December 2011 were retrospectively reviewed. Patients whose high-resolution computed tomography scans showed evidence of labyrinthine calcification of the temporal bone were enrolled. Read More

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http://search.proquest.com/openview/6174d5d6163da3d117f77ddf
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http://www.journals.cambridge.org/abstract_S002221511400111X
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http://dx.doi.org/10.1017/S002221511400111XDOI Listing
July 2014
14 Reads

Utility of MRIs in adult cochlear implant evaluations.

Otol Neurotol 2014 Oct;35(9):1533-5

Department of Otolaryngology-Head and Neck Surgery, University of Texas at Southwestern, Dallas, Texas, U.S.A.

Objectives: To determine the prevalence of MRI abnormalities in adults undergoing cochlear implantation and to correlate abnormalities to audiology data.

Study Design: Case series.

Setting: Academic medical center. Read More

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https://insights.ovid.com/crossref?an=00129492-201410000-000
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http://dx.doi.org/10.1097/MAO.0000000000000453DOI Listing
October 2014
10 Reads

Intensity of gadolinium enhancement on MRI is useful in differentiation of intracochlear inflammation from tumor.

Otol Neurotol 2014 Jun;35(5):905-10

*New York University School of Medicine; †Department of Radiology, and ‡Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, New York, U.S.A.

Objective: Magnetic resonance imaging is the gold standard in retrocochlear imaging; however, its role in management of inner ear diseases remains poorly defined. In this study, we investigate the utility of MRI in defining the nature of intracochlear pathology.

Study Design: A retrospective review of 11 patients with inner ear abnormalities on MRI between 2010 and 2013. Read More

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http://dx.doi.org/10.1097/MAO.0000000000000300DOI Listing
June 2014
6 Reads

microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation.

Hum Mol Genet 2014 Jun 26;23(12):3138-46. Epub 2014 Jan 26.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 68878, Israel and

microRNAs (miRNAs) are regulators of differentiation and development of inner ear cells. Mutations in miRNAs lead to deafness in humans and mice. Among inner ear pathologies, inflammation may lead to structural and neuronal defects and eventually to hearing loss and vestibular dysfunction. Read More

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http://dx.doi.org/10.1093/hmg/ddu023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030769PMC
June 2014
2 Reads