897 results match your criteria Inner Ear Autoimmune Disease


Cochlear Implantation as a Treatment for Sudden Autoimmune Sensorineural Hearing Loss in a Patient Affected by Eosinophilic Granulomatosis with Polyangiitis: A Case Report and A Review of Literature.

Ann Otol Rhinol Laryngol 2020 Jul 2:3489420938827. Epub 2020 Jul 2.

Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

Objective: To report presentation, diagnostic process, management and outcome of a case of autoimmune inner ear disease (AIED) related with Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), treated with cochlear implantation, and review of relevant literature.

Case Presentation And Management: A retrospective case report of AIED associated with EGPA treated with cochlear implantation was described. A multi-step approach for diagnosis and confirmation of AIED and hearing rehabilitation was conducted, eventually leading to left cochlear implantation. Read More

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http://dx.doi.org/10.1177/0003489420938827DOI Listing

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review.

Front Public Health 2020 29;8:252. Epub 2020 May 29.

Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. Chloroquine and hydroxychloroquine, typically used for the treatment of malaria and autoimmune diseases, have been considered for off-label use in several countries. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273970PMC

The pharmacological management of vertigo in Meniere disease.

Expert Opin Pharmacother 2020 Jun 15:1-11. Epub 2020 Jun 15.

Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs.GRANADA, Hospital Universitario Virgen de las Nieves, Universidad de Granada , Granada, Spain.

Introduction: The term Meniere disease (MD) gathers a set of rare diseases involving the inner ear characterized by episodic vertigo associated with fluctuating auditory symptoms. Five clinical subgroups of patients have been defined, including familial MD, autoimmune MD, and MD with migraine. The diagnosis is based on clinical criteria as no biomarker is available, but genetic factors have a significant contribution in familial and non-familial MD. Read More

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http://dx.doi.org/10.1080/14656566.2020.1775812DOI Listing

Evaluation of hearing function in patients with lichen planus.

Med Hypotheses 2020 May 22;143:109867. Epub 2020 May 22.

Inonu University Faculty of Medicine, Department of Dermatology, Malatya, Turkey.

Lichen planus (LP) is a chronic, autoimmune, inflammatory disease. We believe that tympanic membrane and outer ear canal can be affected by the disease and since it is an autoimmune disease inner ear involvement may be seen. The aim of this study was to evaluate hearing functions in patients with LP. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109867DOI Listing

Evaluation of audiovestibular system in psoriasis patients without joint involvement.

Dermatol Ther 2020 May 25;33(3):e13396. Epub 2020 Apr 25.

Department of Audiology, Karabuk University Training and Research Hospital, Karabuk, Turkey.

Inner ear involvement may occur in systemic autoimmune diseases. Although there are studies evaluating hearing in psoriasis patients, its effect on the balance system is not clear. The aim of the present study was to evaluate the audiovestibular system in psoriasis patients without joint involvement. Read More

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http://dx.doi.org/10.1111/dth.13396DOI Listing

Delivery of benzoylaconitine using biodegradable nanoparticles to suppress inflammation via regulating NF-κB signaling.

Colloids Surf B Biointerfaces 2020 Jul 31;191:110980. Epub 2020 Mar 31.

School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin, 300350, China; Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin, 300350, China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, China. Electronic address:

Rheumatoid arthritis (RA) is a kind of systemic autoimmune disease, and patients with RA usually suffer serious pain, resulting in low quality of life. The development of drug delivery systems (DDSs) provides a valid approach for RA therapy via inhibiting the secretion of inflammatory cytokines from macrophages. As a prevailing drug nanocarrier with distinctive superiority, polymeric nanoparticles (NPs) have attracted much attention in recent years. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.110980DOI Listing

Vogt-Koyanagi-Harada disease during chemoimmunotherapy for non-small cell lung cancer.

Respirol Case Rep 2020 Apr 28;8(3):e00545. Epub 2020 Feb 28.

Department of Respiratory Medicine Japanese Red Cross Kyoto Daini Hospital Kyoto Japan.

Vogt-Koyanagi-Harada disease (VKHD) is a rare systemic granulomatous autoimmune disease that affects melanocyte-rich organs such as eye, inner ear, meninges, skin, and hair. VKHD leads to chronic uveal inflammation accompanied by a decline in visual acuity in some patients when appropriate corticosteroid treatment was not initiated in an early phase. Immune checkpoint inhibitors (ICIs) are widely used in the treatment of several kinds of cancers and chemoimmunotherapy has become the standard of care in the first-line treatment of non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1002/rcr2.545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047218PMC

Cochlear Implant Performance in Adult Patients with Absent Intraoperative Electrically Evoked Compound Action Potentials.

Otolaryngol Head Neck Surg 2020 May 3;162(5):725-730. Epub 2020 Mar 3.

Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Objective: To describe cochlear implant performance outcomes in adult patients in whom no intraoperative electrically evoked compound action potential (ECAP) responses were able to be obtained despite intracochlear electrode placement.

Study Design: Retrospective case review.

Setting: Academic tertiary center. Read More

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http://dx.doi.org/10.1177/0194599820907572DOI Listing

Autoimmune inner ear disease patient-associated 28-kDa proinflammatory IL-1β fragment results from caspase-7-mediated cleavage in vitro.

JCI Insight 2020 Feb 13;5(3). Epub 2020 Feb 13.

Feinstein Institutes for Medical Research, Manhasset, New York, USA.

Interleukin-1β (IL-1β) is a key proinflammatory cytokine involved in the progression of many autoinflammatory and autoimmune diseases, including autoimmune inner ear disease (AIED). IL-1β inhibition has been shown to result in clinical hearing improvement in a small cohort of corticosteroid-resistant patients with AIED. Canonical processing of pro-IL-1β by caspase-1 generates an active 17-kDa fragment, capable of instigating a proinflammatory microenvironment. Read More

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http://dx.doi.org/10.1172/jci.insight.130845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098783PMC
February 2020

[Susac syndrome - an unusual syndrome which can be mistaken for multiple sclerosis].

Lakartidningen 2020 02 10;117. Epub 2020 Feb 10.

Karolinska Hospital - Department of Neurology Stockholm, Sweden Karolinska Hospital - Stockholm, Sweden.

Susac syndrome is an autoimmune disease characterized by the clinical triad of encephalopathy, branch retinal artery occlusions and sensorineural hearing loss. It most commonly affects young women. Susac syndrome is most likely underdiagnosed, not the least since only 13% have the clinical triad upon presentation. Read More

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February 2020

Electrophysiological and inner ear MRI findings in patients with bilateral vestibulopathy.

Eur Arch Otorhinolaryngol 2020 May 8;277(5):1305-1314. Epub 2020 Feb 8.

Centre d'Explorations Fonctionnelles Otoneurologiques, Paris, France.

Purpose: Bilateral vestibulopathy (BV) is an uncommon disorder and the etiology remained idiopathic in most cases. Delayed 3D-FLAIR sequences have provided new insights into various inner ear diseases, allowing the evaluation of the endolymphatic space and the permeability of the blood-labyrinthine barrier (BLB). The aim of this study was to assess both the morphology of the endolymphatic space and the permeability of the BLB in patients with BV as evaluated by delayed 3D-FLAIR sequences. Read More

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http://dx.doi.org/10.1007/s00405-020-05829-8DOI Listing

Review of the pathology underlying benign paroxysmal positional vertigo.

Authors:
Sertac Yetiser

J Int Med Res 2019 Dec 29:300060519892370. Epub 2019 Dec 29.

Department of Otolaryngology-Head and Neck Surgery, Anadolu Medical Center, Gebze, Kocaeli, Turkey.

The pathophysiological mechanism underlying benign paroxysmal positional vertigo (BPPV) is related to free-floating debris/otoliths in the semicircular canal (canalolithiasis) or debris/otoliths attached to the cupula (cupulolithiasis). These debris/otoliths are considered to originally accumulate after detachment from the neuroepithelium of the utricular macula secondary to a type of degeneration. An idiopathic form, which is assumed to occur spontaneously, is diagnosed when the causative pathology is obscure. Read More

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http://dx.doi.org/10.1177/0300060519892370DOI Listing
December 2019

An update on autoimmune inner ear disease: A systematic review of pharmacotherapy.

Am J Otolaryngol 2020 Jan - Feb;41(1):102310. Epub 2019 Oct 28.

Division of Otolaryngology-Head and Neck Surgery, George Washington University, 2300 M St NW, 4th floor, Washington, DC 20037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.amjoto.2019.102310DOI Listing
October 2019
8 Reads

Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.

Authors:
Yi-Ho Young

Int J Audiol 2020 Apr 12;59(4):243-253. Epub 2019 Nov 12.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

This article provides an overview of the causes and differential diagnosis of sudden deafness (SD) and sudden sensorineural hearing loss (SSHL). Contemporary review. This review is based on peer-reviewed articles published in those journals listed on journal of citation reports. Read More

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http://dx.doi.org/10.1080/14992027.2019.1689432DOI Listing

Evaluation of medial olivocochlear efferent system and hearing loss in patients with primary Sjögren’s syndrome

Turk J Med Sci 2019 12 16;49(6):1647-1654. Epub 2019 Dec 16.

Background/aim: Autoimmune diseases are a remarkable issue for researchers due to their adverse effects on the auditory system, but for primary Sjögren’s syndrome (pSS) there is little research on the comprehensive audiological findings in literature. The main objective of this study was to investigate the medial olivocochlear efferent functions of subjects with pSS and to examine the audiological findings.

Materials And Methods: The study included 36 subjects with pSS and 36 healthy subjects. Read More

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http://dx.doi.org/10.3906/sag-1901-128DOI Listing
December 2019

Vogt-Koyanagi-Harada Syndrome in a Ugandan: Diagnostic and Therapeutic Challenges.

Case Rep Med 2019 16;2019:5192754. Epub 2019 Sep 16.

Department of Internal Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.

Background: Vogt-Koyanagi-Harada (VKH) syndrome is a multisystemic autoimmune disease of uncertain pathogenesis. Infectious aetiology has been proposed which is suggested to lead to the loss of melanocytes in the skin, inner ear, meninges, and uvea in those who are genetically predisposed. Information regarding VKH syndrome is scanty among the African population. Read More

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http://dx.doi.org/10.1155/2019/5192754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766141PMC
September 2019
1 Read

Is Early Progression to Bilateral Involvement in Menière's Disease a Poor Prognostic Indicator?

Otol Neurotol 2019 12;40(10):1333-1338

Department of Otorhinolaryngology, Yonsei University College of Medicine.

Objective: To investigate differences in the clinical features of bilateral Menière's disease (BMD) with early and late bilateral involvement.

Study Design: A retrospective case-comparison study.

Setting: Tertiary referral center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002368DOI Listing
December 2019
1 Read

Pediatric Autoimmune Inner Ear Disease: A Rare, But Treatable Condition.

Pediatr Ann 2019 Oct;48(10):e391-e394

Autoimmune inner ear disease (AIED) is a rare, but treatable cause of sudden sensorineural hearing loss in children. Most cases present acutely and involve both ears. The precise mechanism of hearing loss in AIED is not known. Read More

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http://dx.doi.org/10.3928/19382359-20190923-01DOI Listing
October 2019
2 Reads

Demystifying autoimmune inner ear disease.

Eur Arch Otorhinolaryngol 2019 Dec 11;276(12):3267-3274. Epub 2019 Oct 11.

Department of ENT, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, 522503, India.

Introduction: Autoimmune inner disease (AIED) is an uncommon cause of sensorineural hearing loss and poses a diagnostic challenge. The present study aims to review the existing knowledge on the clinicopathological aspects, the diagnostic challenges, and therapeutic interventions in AIED.

Discussion: The incidence of AIED is less than five cases per 100,000 population. Read More

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http://dx.doi.org/10.1007/s00405-019-05681-5DOI Listing
December 2019
1 Read

Immunoglobulin G4-Related Disease Presented as Recurrent Otitis Media and Mixed Hearing Loss Treated With Cyclophosphamide and Rituximab: A Case Report.

Arch Rheumatol 2019 Jun 30;34(2):233-237. Epub 2018 Nov 30.

Department Rheumatology, China Medical University Hospital, Taichung, Taiwan.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic autoimmune disease; however, it rarely presents as recurrent otitis media and mixed hearing loss. In this article, we present a 43-year-old male patient who presented with recurrent otitis media and mixed hearing loss that is the 12th case of IgG4-RD with middle and inner ear involvement. We also report the clinical response of cyclophosphamide and rituximab therapy in IgG4- RD. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2019.7178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719581PMC
June 2019
7 Reads

Effects of type 1 diabetes mellitus on efferent auditory system in children and adolescents.

Int J Pediatr Otorhinolaryngol 2019 Dec 25;127:109660. Epub 2019 Aug 25.

Pediatric Endocrinology Unit. University Hospital Prof. Edgard Santos, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.

Aim: To investigate whether type 1 diabetes mellitus (T1DM) could affect the efferent auditory system by analyzing the relationship between the activation of the medial olivocochlear reflex with disease duration, metabolic control and age at time of diagnosis.

Method: A total of 101 children and adolescents were evaluated. They were divided into two groups: 50 with T1DM and 51 without the disease. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.109660DOI Listing
December 2019
2 Reads

The natural progression of low-frequency hearing loss in patients who meet hybrid implant system candidacy criteria.

Laryngoscope 2020 May 8;130(5):1299-1303. Epub 2019 Aug 8.

Department of Otolaryngology, Massachusetts Eye and Ear and Harvard University, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: To investigate the natural progression of hearing loss in patients with high-frequency hearing loss whose audiograms met the criteria for a hybrid cochlear implant (CI).

Study Design: Retrospective database review.

Methods: We retrospectively identified patients who met the criteria for a hybrid CI from our audiometric database. Read More

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http://dx.doi.org/10.1002/lary.28217DOI Listing
May 2020
2 Reads

Fluctuating Sensorineural Hearing Loss.

Audiol Neurootol 2019 17;24(3):109-116. Epub 2019 Jul 17.

House Clinic and House Ear Institute, Los Angeles, California, USA.

Background: Several otologic conditions can present with fluctuating sensorineural hearing loss, including Ménière's disease, autoimmune inner ear disease, and enlarged vestibular aqueduct. Although these 3 etiologies vary greatly, distinguishing between these conditions at initial presentation can be challenging. Furthermore, initial treatment of these conditions is often similar. Read More

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http://dx.doi.org/10.1159/000500658DOI Listing
April 2020
2 Reads

[Susac syndrome, a rare cause of encephalopathy].

Medicina (B Aires) 2019 ;79(3):204-207

Clínica de Ojos Aranda, Posadas, Misiones, Argentina.

Susac syndrome is a rare disorder caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear. These occlusions lead to a characteristic clinical triad of central nervous system dysfunction, visual disturbances and vestibule-cochlear deficits. The diagnosis is based on clinical manifestations and complementary studies, which demonstrate the involvement of three systems. Read More

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July 2019
11 Reads

Bilateral Cochlear Implantation in Vogt-Koyanagi-Harada Syndrome: A Case Report.

Otol Neurotol 2019 08;40(7):e694-e697

Department of Otolaryngology, Neurotology & Skull Base Surgery, King Saud University, Riyadh, Saudi Arabia.

Objective: To evaluate cochlear implantation in Vogt-Koyanagi-Harada syndrome with regard to surgical difficulties and hearing outcomes.

Patients: Single case report.

Intervention(s): Therapeutic complete electrode insertion during surgery despite evident intra-cochlear fibrosis. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002262DOI Listing
August 2019
9 Reads

The Price of Immune Responses and the Role of Vitamin D in the Inner Ear.

Otol Neurotol 2019 07;40(6):701-709

Vestibular Genetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska.

Objective: In this review the authors discuss evidence from the literature concerning vitamin D and temporal bone diseases (benign paroxysmal positional vertigo [BPPV], Menière's disease [MD], vestibular neuritis, idiopathic facial paralysis, idiopathic acute hearing loss). Common features shared by Menière's disease, glaucoma, and the possible influence by vitamin D are briefly discussed.

Data Sources, Study Selection: Publications from 1970 until recent times have been reviewed according to a keyword search (see above) in PubMed. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578582PMC
July 2019
6 Reads

Cochlear involvement in patients with systemic autoimmune rheumatic diseases: a clinical and laboratory comparative study.

Eur Arch Otorhinolaryngol 2019 Sep 30;276(9):2419-2426. Epub 2019 May 30.

Department of Rheumatology, University Hospital of Ioannina, Ioannina, Greece.

Purpose: Inner ear involvement has been reported in systemic rheumatic disease while detection of cochlin-specific antibodies has been reported in patients with idiopatic sensorineural hearing loss, suggesting cochlin's strong link to autoimmune hearing loss. The aim of this cross-sectional study was to calculate the prevalence of sensorineural hearing loss (SNHL) in patients with systemic rheumatic diseases, and to investigate any potential correlation with human antibodies to cochlin.

Methods: Patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren's syndrome (SS) and systemic sclerosis (SSc) according to the criteria of American College of Rheumatology were included in the study. Read More

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http://dx.doi.org/10.1007/s00405-019-05487-5DOI Listing
September 2019
24 Reads
1.608 Impact Factor

Subclinical cochlear dysfunction in newly diagnosed relapsing-remitting multiple sclerosis.

Mult Scler Relat Disord 2019 Aug 27;33:55-60. Epub 2019 May 27.

Department of Neurosciences, Tor Vergata University, Rome, Italy.

Background: Hearing impairment in multiple sclerosis has long been considered a process mainly related to the central auditory system. However, increasing evidence also suggests a peripheral involvement of the inner ear. The objective of this study was to investigate subclinical cochlear dysfunction and possible correlation with disease severity in untreated newly diagnosed multiple sclerosis patients using transient-evoked and distortion-product otoacoustic emissions. Read More

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http://dx.doi.org/10.1016/j.msard.2019.05.020DOI Listing
August 2019
11 Reads

miR‑10b‑3p, miR‑8112 and let‑7j as potential biomarkers for autoimmune inner ear diseases.

Mol Med Rep 2019 Jul 16;20(1):171-181. Epub 2019 May 16.

Department of Otolaryngology/Head and Neck Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Circulating microRNAs (miRNAs) have been suggested as non‑invasive biomarkers for the diagnosis of several autoimmune diseases. However, to the best of our knowledge, no studies have yet examined the miRNA expression profiles in autoimmune inner ear disease (AIED). The present study aimed to use an miRNA sequencing assay to detect the miRNA expression profiles of serum samples from 3 control mice and 3 antigen‑induced AIED model mice. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10248
Publisher Site
http://dx.doi.org/10.3892/mmr.2019.10248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579970PMC
July 2019
21 Reads

Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1312-1320

a Department of Otolaryngology, Hearing Research Laboratory , University of Miami Miller School of Medicine , Miami , FL, USA.

Hearing loss is the most common neurosensory impairment worldwide. While conductive hearing loss can be managed by surgery, the management of sensorineural hearing loss (SNHL), related to the damage of sensory cells of the inner ear is more challenging to manage medically. Many causes of SNHL such as sudden idiopathic SNHL, Meniere's disease, noise-induced hearing loss, autoimmune hearing loss or hearing loss from exposure to ototoxic substances can benefit from delivery of otoprotective drugs to the inner ear. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573182DOI Listing
December 2019
10 Reads

Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.

J Chin Med Assoc 2019 Apr;82(4):272-276

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.

Background: Rheumatoid arthritis (RA) is an autoimmune disease. Sensorineural and conductive hearing loss have been reported in RA, but the results of most studies are not in agreement. The pathogenesis of the hearing loss is not clearly understood. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000036DOI Listing
April 2019
24 Reads

Vogt-Koyanagi-Harada disease.

Pract Neurol 2019 Aug 19;19(4):364-367. Epub 2019 Mar 19.

Birmingham Neuro-Ophthalmology Unit, Ophthalmology Department, University Hospitals Birmingham NHS Trust, Birmingham, UK.

Vogt-Koyanagi-Harada disease is a rare, multisystem, autoimmune disorder with numerous clinical manifestations, mediated through a T-helper 1 response against melanocytes in the eye, inner ear, central nervous system, hair and skin. We describe a 20-year-old British-Honduran man with recent worsening headache and photophobia, vomiting and visual blurring. On examination, his pupils reacted sluggishly and visual acuities were bilaterally reduced. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002152DOI Listing
August 2019
26 Reads

Emerging options in immune-mediated hearing loss.

Laryngoscope Investig Otolaryngol 2019 Feb 3;4(1):102-108. Epub 2018 Dec 3.

Department of Otolaryngology-Head and Neck Surgery University of California, San Diego San Diego California U.S.A.

Objective: AIED (autoimmune inner ear disease) is an autoimmune process that leads to the dysfunction of the inner ear, resulting in fluctuating, audiovestibular symptoms. Although the pathogenesis is likely heterogeneous, immune processes within the inner ear ultimately lead to histopathologic changes and sensorineural hearing loss. This review will discuss the latest evidence on treatment options. Read More

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http://doi.wiley.com/10.1002/lio2.205
Publisher Site
http://dx.doi.org/10.1002/lio2.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383306PMC
February 2019
39 Reads

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques.

mBio 2018 10 30;9(5). Epub 2018 Oct 30.

Office of the Chief Scientists, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. The causal mechanism of hearing loss in LASV-infected patients remains elusive. Here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to LASV exposure control groups in two different studies. Read More

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http://dx.doi.org/10.1128/mBio.01896-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212830PMC
October 2018
36 Reads

Autoimmune inner ear disease (AIED): A diagnostic challenge.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418808680

1 Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy. Read More

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http://dx.doi.org/10.1177/2058738418808680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213300PMC
March 2019
85 Reads

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.

J Immunol Res 2018 26;2018:5072582. Epub 2018 Sep 26.

Department of Neurosciences, Otorhinolaryngology Unit, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. Read More

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http://dx.doi.org/10.1155/2018/5072582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178164PMC
December 2018
13 Reads

Early Sentence Recognition in Adult Cochlear Implant Users.

Ear Hear 2019 Jul/Aug;40(4):905-917

Service ORL, CHU Toulouse, Toulouse, France.

Objective: Normal-hearing subjects listening to acoustic simulations of cochlear implants (CI) can obtain sentence recognition scores near 100% in quiet and in 10 dB signal-to-noise ratio (SNR) noise with acute exposure. However, average sentence recognition scores for real CI listeners are generally lower, even after months of experience, and there is a high degree of heterogeneity. Our aim was to identify the relative importance and strength of factors that prevent CI listeners from achieving early, 1-mo scores as high as those for normal-hearing-listener acoustic simulations. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000670DOI Listing
January 2020
45 Reads

Clinical manifestations of hydropic ear disease (Menière's).

Eur Arch Otorhinolaryngol 2019 Jan 10;276(1):27-40. Epub 2018 Oct 10.

Department of Otorhinolaryngology, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

Introduction: Hydropic ear disease, initially described by and named after Prosper Menière, is one of the most frequent vertigo disorders and one of the most frequent inner ear disorders. It is the syndrome of endolymphatic hydrops which until 2007 could be diagnostically confirmed only by post-mortem histology. In the past, various attempts to formulate clinical diagnostic criteria have been undertaken but were hampered by the inability to ascertain the diagnosis in living patients. Read More

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http://dx.doi.org/10.1007/s00405-018-5157-3DOI Listing
January 2019
27 Reads

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group.

Laryngoscope 2019 05 3;129(5):1191-1196. Epub 2018 Oct 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Objectives/hypothesis: To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population.

Study Design: Cross-sectional retrospective study.

Methods: We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Read More

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http://dx.doi.org/10.1002/lary.27423DOI Listing
May 2019
14 Reads

Investigation of high-frequency hearing loss and outer hair cell function of the cochlea in patients with psoriasis: a case-control study.

Clin Exp Dermatol 2019 Jul 2;44(5):520-523. Epub 2018 Oct 2.

Department of Otolaryngology and HNS, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

The inner ear can be the target of autoimmune attacks, and sensorineural hearing loss can occur as a complication in various non-organ-specific autoimmune diseases. The aim of this study was to compare cochlear functions and hearing evaluation in patients with psoriasis and controls. In total, 29 patients with psoriasis and 30 healthy controls (HCs) were included in the study. Read More

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http://doi.wiley.com/10.1111/ced.13805
Publisher Site
http://dx.doi.org/10.1111/ced.13805DOI Listing
July 2019
12 Reads

Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.

Immunol Res 2018 12;66(6):675-685

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.

The role of the immune system in mediating cochleovestibular pathologies has received increasing attention in recent years. Autoimmune vertigo may be an invalidating condition and may worsen the quality of life of affected patients, especially in the cases of delayed diagnosis. Since the etiopathogenesis is still not clear, also the treatment is not yet completely delineated. Read More

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http://dx.doi.org/10.1007/s12026-018-9023-6DOI Listing
December 2018
34 Reads

Audiovestibular Symptoms in Systemic Autoimmune Diseases.

J Immunol Res 2018 19;2018:5798103. Epub 2018 Aug 19.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Read More

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https://www.hindawi.com/journals/jir/2018/5798103/
Publisher Site
http://dx.doi.org/10.1155/2018/5798103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292PMC
November 2018
47 Reads

Screening of genes associated with inflammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases.

Exp Ther Med 2018 Sep 19;16(3):2460-2470. Epub 2018 Jul 19.

Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

The current study analyzed gene expression profiles of the endolymphatic sac (ES) in rats and identified expressed genes, present in the human and rat ES, to reveal key hubs for inflammatory responses. Microarray data (accession no. E-MEXP-3022) were obtained from the European Bioinformatics Institute database, including three biological replicates of ES plus dura tissues and three replicates of pure dura tissues form rats. Read More

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http://dx.doi.org/10.3892/etm.2018.6479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122540PMC
September 2018
17 Reads

Autoimmune inner ear disease secondary to Hashimoto's thyroiditis: a case report.

J Community Hosp Intern Med Perspect 2018 23;8(4):227-229. Epub 2018 Aug 23.

Internal Medicine, Greater Baltimore Medical Center, MD, USA.

Autoimmune inner ear disease is an important yet incompletely understood cause of hearing loss which can present to different medical disciplines. Its diagnostic significance is indicated by the fact that it is a reversible medical condition if recognized early with an excellent response to immunosuppressive agents. Therefore, it should be considered in the differential diagnosis of hearing disorders especially in the context of another autoimmune disease such as Hashimoto's thyroiditis. Read More

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http://dx.doi.org/10.1080/20009666.2018.1503917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116174PMC
August 2018
10 Reads

l-Thyroxine does not prevent immunemediated sensorineural hearing loss in autoimmune thyroid diseases.

Acta Otorrinolaringol Esp 2019 Jul - Aug;70(4):229-234. Epub 2018 Aug 11.

Department of Otorhinolaryngology, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.

Objective: This is the first report dealing with immune-mediated inner ear disease (IMIED) hearing loss in a group of patients affected with autoimmune thyroid disease (AITD), whose treatment required corticosteroids, despite being treated with levothyroxine. Immunopathology linking the inner ear and the thyroid gland is also presented.

Patients: A total of 220 patients were selected with sensorineural hearing loss (SNHL) of causes other than presbycusis. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.06.001DOI Listing
January 2020
11 Reads

Can positron emission tomography support the characterization of immune-mediated inner ear disease?

Rev Esp Med Nucl Imagen Mol 2018 Sep - Oct;37(5):290-295. Epub 2018 Jul 20.

Department of Otorhinolaryngology, Puerta de Hierro Majadahonda University Hospital, Autonomous University of Madrid, España.

Introduction: To evaluate the utility of F-FDG PET/TC as an imaging tool for the characterization of immune-mediated inner ear disease (IMIED), providing measurements of the inner ear region activity as well as detecting possible involvement of other organs.

Material And Methods: The study included 28 patients with IMIED and 4 sex-matched and age-matched control subjects with no history of ear disease. Eighteen patients were considered to be suffering from primary IMIED and 10 patients from secondary. Read More

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http://dx.doi.org/10.1016/j.remn.2018.03.003DOI Listing
June 2019
12 Reads

Inner ear involvement in multiple sclerosis: An underestimated condition?

Mult Scler 2018 08;24(9):1264-1265

2 Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1177/1352458517750010DOI Listing
August 2018
4 Reads
4.822 Impact Factor

Ear Involvement in Inflammatory Bowel Disease: A Review of the Literature.

J Clin Med Res 2018 Aug 27;10(8):609-614. Epub 2018 Jun 27.

Department of Gastroenterology, Medical School of Ioannina, Ioannina, Greece.

Inflammatory bowel disease (IBD) is a multisystemic disease. The ear is a rare but recognized site of extraintestinal manifestations of IBD. In external ear, the more common manifestations of IBD are pyoderma gangrenosum, metastatic Crohn's disease and relapsing polychondritis and the treatment includes corticosteroids and anti-TNF agents. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3465
Publisher Site
http://dx.doi.org/10.14740/jocmr3465wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031254PMC
August 2018
47 Reads

Hypertrophic Pachymeningitis of the Internal Auditory Canal: A Rare Case of Unilateral Sudden Sensorineural Hearing Loss.

Ann Otol Rhinol Laryngol 2018 Sep 25;127(9):649-652. Epub 2018 Jun 25.

1 University of Kansas Department of Otolaryngology-Head and Neck Surgery, Kansas City, Kansas, USA.

Objectives: To describe and increase awareness of a rare cause of unilateral sudden sensorineural hearing loss.

Methods: Case report and literature review.

Results: We present a 66-year-old female who suffered left-sided sudden sensorineural hearing loss and dizziness. Read More

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http://dx.doi.org/10.1177/0003489418784051DOI Listing
September 2018
42 Reads