865 results match your criteria Inner Ear Autoimmune Disease


Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1312-1320

a Department of Otolaryngology, Hearing Research Laboratory , University of Miami Miller School of Medicine , Miami , FL, USA.

Hearing loss is the most common neurosensory impairment worldwide. While conductive hearing loss can be managed by surgery, the management of sensorineural hearing loss (SNHL), related to the damage of sensory cells of the inner ear is more challenging to manage medically. Many causes of SNHL such as sudden idiopathic SNHL, Meniere's disease, noise-induced hearing loss, autoimmune hearing loss or hearing loss from exposure to ototoxic substances can benefit from delivery of otoprotective drugs to the inner ear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21691401.2019.1573182DOI Listing
December 2019
1 Read

Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.

J Chin Med Assoc 2019 Apr;82(4):272-276

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.

Background: Rheumatoid arthritis (RA) is an autoimmune disease. Sensorineural and conductive hearing loss have been reported in RA, but the results of most studies are not in agreement. The pathogenesis of the hearing loss is not clearly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCMA.0000000000000036DOI Listing
April 2019
5 Reads

Vogt-Koyanagi-Harada disease.

Pract Neurol 2019 Mar 19. Epub 2019 Mar 19.

Birmingham Neuro-Ophthalmology Unit, Ophthalmology Department, University Hospitals Birmingham NHS Trust, Birmingham, UK.

Vogt-Koyanagi-Harada disease is a rare, multisystem, autoimmune disorder with numerous clinical manifestations, mediated through a T-helper 1 response against melanocytes in the eye, inner ear, central nervous system, hair and skin. We describe a 20-year-old British-Honduran man with recent worsening headache and photophobia, vomiting and visual blurring. On examination, his pupils reacted sluggishly and visual acuities were bilaterally reduced. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/practneurol-2018-002152DOI Listing
March 2019
3 Reads

Emerging options in immune-mediated hearing loss.

Laryngoscope Investig Otolaryngol 2019 Feb 3;4(1):102-108. Epub 2018 Dec 3.

Department of Otolaryngology-Head and Neck Surgery University of California, San Diego San Diego California U.S.A.

Objective: AIED (autoimmune inner ear disease) is an autoimmune process that leads to the dysfunction of the inner ear, resulting in fluctuating, audiovestibular symptoms. Although the pathogenesis is likely heterogeneous, immune processes within the inner ear ultimately lead to histopathologic changes and sensorineural hearing loss. This review will discuss the latest evidence on treatment options. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/lio2.205
Publisher Site
http://dx.doi.org/10.1002/lio2.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383306PMC
February 2019
20 Reads

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques.

MBio 2018 10 30;9(5). Epub 2018 Oct 30.

Office of the Chief Scientists, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. The causal mechanism of hearing loss in LASV-infected patients remains elusive. Here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to LASV exposure control groups in two different studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01896-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212830PMC
October 2018
8 Reads

Autoimmune inner ear disease (AIED): A diagnostic challenge.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418808680

1 Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2058738418808680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213300PMC
March 2019
49 Reads

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.

J Immunol Res 2018 26;2018:5072582. Epub 2018 Sep 26.

Department of Neurosciences, Otorhinolaryngology Unit, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/5072582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178164PMC
December 2018
7 Reads

Clinical manifestations of hydropic ear disease (Menière's).

Eur Arch Otorhinolaryngol 2019 Jan 10;276(1):27-40. Epub 2018 Oct 10.

Department of Otorhinolaryngology, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

Introduction: Hydropic ear disease, initially described by and named after Prosper Menière, is one of the most frequent vertigo disorders and one of the most frequent inner ear disorders. It is the syndrome of endolymphatic hydrops which until 2007 could be diagnostically confirmed only by post-mortem histology. In the past, various attempts to formulate clinical diagnostic criteria have been undertaken but were hampered by the inability to ascertain the diagnosis in living patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-018-5157-3DOI Listing
January 2019
19 Reads

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group.

Laryngoscope 2019 May 3;129(5):1191-1196. Epub 2018 Oct 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Objectives/hypothesis: To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population.

Study Design: Cross-sectional retrospective study.

Methods: We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27423DOI Listing
May 2019
6 Reads

Investigation of high-frequency hearing loss and outer hair cell function of the cochlea in patients with psoriasis: a case-control study.

Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.

Department of Otolaryngology and HNS, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

The inner ear can be the target of autoimmune attacks, and sensorineural hearing loss can occur as a complication in various non-organ-specific autoimmune diseases. The aim of this study was to compare cochlear functions and hearing evaluation in patients with psoriasis and controls. In total, 29 patients with psoriasis and 30 healthy controls (HCs) were included in the study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ced.13805
Publisher Site
http://dx.doi.org/10.1111/ced.13805DOI Listing
October 2018
7 Reads

Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.

Immunol Res 2018 Dec;66(6):675-685

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.

The role of the immune system in mediating cochleovestibular pathologies has received increasing attention in recent years. Autoimmune vertigo may be an invalidating condition and may worsen the quality of life of affected patients, especially in the cases of delayed diagnosis. Since the etiopathogenesis is still not clear, also the treatment is not yet completely delineated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12026-018-9023-6DOI Listing
December 2018
16 Reads

Audiovestibular Symptoms in Systemic Autoimmune Diseases.

J Immunol Res 2018 19;2018:5798103. Epub 2018 Aug 19.

Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/jir/2018/5798103/
Publisher Site
http://dx.doi.org/10.1155/2018/5798103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292PMC
November 2018
23 Reads

Screening of genes associated with inflammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases.

Exp Ther Med 2018 Sep 19;16(3):2460-2470. Epub 2018 Jul 19.

Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

The current study analyzed gene expression profiles of the endolymphatic sac (ES) in rats and identified expressed genes, present in the human and rat ES, to reveal key hubs for inflammatory responses. Microarray data (accession no. E-MEXP-3022) were obtained from the European Bioinformatics Institute database, including three biological replicates of ES plus dura tissues and three replicates of pure dura tissues form rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.6479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122540PMC
September 2018
4 Reads

Autoimmune inner ear disease secondary to Hashimoto's thyroiditis: a case report.

J Community Hosp Intern Med Perspect 2018 23;8(4):227-229. Epub 2018 Aug 23.

Internal Medicine, Greater Baltimore Medical Center, MD, USA.

Autoimmune inner ear disease is an important yet incompletely understood cause of hearing loss which can present to different medical disciplines. Its diagnostic significance is indicated by the fact that it is a reversible medical condition if recognized early with an excellent response to immunosuppressive agents. Therefore, it should be considered in the differential diagnosis of hearing disorders especially in the context of another autoimmune disease such as Hashimoto's thyroiditis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20009666.2018.1503917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116174PMC
August 2018
4 Reads

l-Thyroxine does not prevent immunemediated sensorineural hearing loss in autoimmune thyroid diseases.

Acta Otorrinolaringol Esp 2018 Aug 11. Epub 2018 Aug 11.

Department of Otorhinolaryngology, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.

Objective: This is the first report dealing with immune-mediated inner ear disease (IMIED) hearing loss in a group of patients affected with autoimmune thyroid disease (AITD), whose treatment required corticosteroids, despite being treated with levothyroxine. Immunopathology linking the inner ear and the thyroid gland is also presented.

Patients: A total of 220 patients were selected with sensorineural hearing loss (SNHL) of causes other than presbycusis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otorri.2018.06.001DOI Listing
August 2018
3 Reads

Can positron emission tomography support the characterization of immune-mediated inner ear disease?

Rev Esp Med Nucl Imagen Mol 2018 Sep - Oct;37(5):290-295. Epub 2018 Jul 20.

Department of Otorhinolaryngology, Puerta de Hierro Majadahonda University Hospital, Autonomous University of Madrid, España.

Introduction: To evaluate the utility of F-FDG PET/TC as an imaging tool for the characterization of immune-mediated inner ear disease (IMIED), providing measurements of the inner ear region activity as well as detecting possible involvement of other organs.

Material And Methods: The study included 28 patients with IMIED and 4 sex-matched and age-matched control subjects with no history of ear disease. Eighteen patients were considered to be suffering from primary IMIED and 10 patients from secondary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.remn.2018.03.003DOI Listing
July 2018
6 Reads

Ear Involvement in Inflammatory Bowel Disease: A Review of the Literature.

J Clin Med Res 2018 Aug 27;10(8):609-614. Epub 2018 Jun 27.

Department of Gastroenterology, Medical School of Ioannina, Ioannina, Greece.

Inflammatory bowel disease (IBD) is a multisystemic disease. The ear is a rare but recognized site of extraintestinal manifestations of IBD. In external ear, the more common manifestations of IBD are pyoderma gangrenosum, metastatic Crohn's disease and relapsing polychondritis and the treatment includes corticosteroids and anti-TNF agents. Read More

View Article

Download full-text PDF

Source
http://www.jocmr.org/index.php/JOCMR/article/view/3465
Publisher Site
http://dx.doi.org/10.14740/jocmr3465wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031254PMC
August 2018
21 Reads

Hypertrophic Pachymeningitis of the Internal Auditory Canal: A Rare Case of Unilateral Sudden Sensorineural Hearing Loss.

Ann Otol Rhinol Laryngol 2018 Sep 25;127(9):649-652. Epub 2018 Jun 25.

1 University of Kansas Department of Otolaryngology-Head and Neck Surgery, Kansas City, Kansas, USA.

Objectives: To describe and increase awareness of a rare cause of unilateral sudden sensorineural hearing loss.

Methods: Case report and literature review.

Results: We present a 66-year-old female who suffered left-sided sudden sensorineural hearing loss and dizziness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0003489418784051DOI Listing
September 2018
19 Reads

Bilateral Vestibular Weakness.

Front Neurol 2018 31;9:344. Epub 2018 May 31.

Department of Neurology, Dr. Cesar Milstein Hospital, Buenos Aires, Argentina.

Bilateral vestibular weakness (BVW) is a rare cause of imbalance. Patients with BVW complain of oscillopsia. In approximately half of the patients with BVW, the cause remains undetermined; in the remainder, the most common etiology by far is gentamicin ototoxicity, followed by much rarer entities such as autoimmune inner ear disease, meningitis, bilateral Ménière's disease, bilateral vestibular neuritis, and bilateral vestibular schwannomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2018.00344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990606PMC
May 2018
17 Reads

Intratympanic gadolinium magnetic resonance imaging supports the role of endolymphatic hydrops in the pathogenesis of immune-mediated inner-ear disease.

J Laryngol Otol 2018 Jun 11;132(6):554-559. Epub 2018 Jun 11.

Department of Otolaryngology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.

Objective: To evaluate the presence of endolymphatic hydrops in patients with immune-mediated inner-ear disease.

Methods: The presence of endolymphatic hydrops was prospectively evaluated in 17 patients clinically diagnosed with secondary (n = 5) or primary (n = 12) immune-mediated inner-ear disease, who attended the ENT department of a tertiary care centre for evaluation or treatment over the previous year. All patients underwent magnetic resonance imaging of the temporal bone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022215118000749DOI Listing
June 2018
5 Reads

Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan's Syndrome.

J Immunol Res 2018 23;2018:1498640. Epub 2018 Apr 23.

Department of Otolaryngology-Head and Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, Israel.

Cogan's syndrome (CS) is a rare autoimmune disorder characterized by audiovestibular dysfunction and ocular inflammation. Currently, there is no specific serum autoantibody used in the diagnostic workup of CS. Treatment is based on immunosuppressive agents, mainly corticosteroids as first-line choice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/1498640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937438PMC
October 2018
9 Reads

Cochlear implantation in patients with bilateral deafness caused by otitis media with ANCA-associated vasculitis (OMAAV): A report of four cases.

Auris Nasus Larynx 2018 Oct 25;45(5):922-928. Epub 2018 May 25.

Department of Otolaryngology - Head and Neck Surgery, Asahikawa Medical University, Japan.

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without systemic symptoms but with initial symptoms related to the ear, such as hearing loss, otalgia, and dizziness, has recently been reported. We have categorized this condition as otitis media with AAV (OMAAV), and have recently proposed its diagnostic criteria.

Methods: To determine the effectiveness of cochlear implantation (CI) in patients with profound hearing loss due to OMAAV. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03858146173041
Publisher Site
http://dx.doi.org/10.1016/j.anl.2017.12.007DOI Listing
October 2018
9 Reads

[Bilateral vestibulopathy].

Authors:
R Huang G R Bi

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(24):1937-1939

Department of Neurology, Shengjing Hospital of China Medical University.

The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait, deficits of spatial memory and navigation. The etiology of BVP remains unclear in more than 50% of patients: in these cases neurodegeneration is assumed. Frequent known causes are ototoxicity mainly due to gentamicin, bilateral Menière's disease, autoimmune diseases, meningitis and bilateral vestibular schwannoma, as well as an association with cerebellar degeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13201/j.issn.1001-1781.2017.24.018DOI Listing
December 2017
5 Reads

The role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease patients. A case control study.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):45-52. Epub 2018 May 10.

Department of Audiology, Faculty of Medicine, Tanta University, Egypt.

Objectives: To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered.

Methods: Thirty patients with BD and thirty apparently sex- and age-matched healthy volunteers were included in this study. Read More

View Article

Download full-text PDF

Source
March 2019
21 Reads

Hearing loss in autoimmune disorders: Prevalence and therapeutic options.

Autoimmun Rev 2018 Jul 3;17(7):644-652. Epub 2018 May 3.

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100 Rome, Italy. Electronic address:

The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.01.014DOI Listing
July 2018
37 Reads

Auditory function and motor proficiency in type 1 diabetic children: A case-control study.

Int J Pediatr Otorhinolaryngol 2018 Jun 19;109:7-12. Epub 2018 Mar 19.

Otolaryngologic Resident, Rhino-Sinus Ear Skull Base Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Objectives: The aim of the study was to evaluate the auditory and motor functions in children with insulin dependent diabetes mellitus (IDDM).

Methods: This case-control study, 65 diabetic children, receiving care in Diabetes Center of 17 Sharivar Hospital, were enrolled. 130 controls were matched to cases by age and sex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2018.03.017DOI Listing
June 2018
8 Reads

Chronic inflammatory demyelinating polyneuropathy: evaluation of the vestibular system with cervical and ocular vestibular evoked myogenic potentials.

Eur Arch Otorhinolaryngol 2018 Jun 27;275(6):1507-1512. Epub 2018 Apr 27.

Department of Neurology and Psychiatry, University "Sapienza", Rome, Italy.

Purpose: To investigate the possibility of vestibular damage in a group of patients suffering from chronic inflammatory demyelinating polyneuropathy (CIDP) using a diagnostic protocol including the caloric test, C-VEMPs and O-VEMPs.

Methods: Twenty patients suffering from CIDP (mean age 58.5 years, range 33-80 years; 4 women and 16 men) were investigated. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00405-018-4981-9
Publisher Site
http://dx.doi.org/10.1007/s00405-018-4981-9DOI Listing
June 2018
15 Reads

Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients.

Mater Sociomed 2018 Mar;30(1):29-31

Department of Dermatology, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Introduction: Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity among vitiligo patients. Read More

View Article

Download full-text PDF

Source
http://www.ejmanager.com/fulltextpdf.php?mno=291040
Publisher Site
http://dx.doi.org/10.5455/msm.2018.30.29-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857041PMC
March 2018
14 Reads

Immune-Mediated Inner Ear Disease: Diagnostic and therapeutic approaches.

Acta Otorrinolaringol Esp 2019 Mar - Apr;70(2):97-104. Epub 2018 Mar 7.

Department of Otorhinolaryngology, Centro-Hospitalar Vila Nova de Gaia-Espinho, Vila Nova de Gaia, Portugal.

Introduction: Immune Mediated Inner Ear Disease (IMIED) is a rare form of sensorineural bilateral hearing loss, usually progressing in weeks to months and responsive to immunosuppressive treatment. Despite recent advances, there is no consensus on diagnosis and optimal treatment.

Methods: A review of articles on IMIED from the last 10 years was conducted using PubMed database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otorri.2017.08.008DOI Listing
March 2018
17 Reads

Azathioprine reduces the risk of audiometric relapse in immune-mediated hearing loss.

Acta Otorrinolaringol Esp 2018 Sep - Oct;69(5):260-267. Epub 2018 Mar 2.

Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.

Introduction: Current schemes for treatment of immune-mediated hearing loss with sporadic short-course, low-dose corticosteroids, are insufficient.

Methods: To determine the role of azathioprine in the control of auditory impairment, a longitudinal, observational, descriptive study was performed with 20 patients treated with azathioprine (1.5-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otorri.2017.08.006DOI Listing
April 2019
5 Reads

Audiological Profile in Primary Sjögren's Syndrome in a Tertiary Care Setting and its Clinical Implications.

Indian J Otolaryngol Head Neck Surg 2018 Mar 17;70(1):59-65. Epub 2015 Dec 17.

1Department of ENT, Christian Medical College, Vellore, India.

This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren's syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren's syndrome in our tertiary care hospital. All patients underwent a puretone audiogram, tympanogram and acoustic reflex testing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12070-015-0956-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807275PMC
March 2018
10 Reads

Regulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere's Disease.

Front Immunol 2017 13;8:1739. Epub 2017 Dec 13.

Otology and Neurotology Group CTS495, Department of Genomic Medicine - Centre for Genomics and Oncological Research - Pfizer/Universidad de Granada/Junta de Andalucía (GENYO), Granada, Spain.

Meniere's disease (MD) is a rare disorder characterized by episodic vertigo, sensorineural hearing loss, tinnitus, and aural fullness. It is associated with a fluid imbalance between the secretion of endolymph in the cochlear duct and its reabsorption into the subarachnoid space, leading to an accumulation of endolymph in the inner ear. Epidemiological evidence, including familial aggregation, indicates a genetic contribution and a consistent association with autoimmune diseases (AD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.01739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733484PMC
December 2017
41 Reads

Optimal management of Cogan's syndrome: a multidisciplinary approach.

J Multidiscip Healthc 2018 22;11:1-11. Epub 2017 Dec 22.

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JMDH.S150940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743115PMC
December 2017
58 Reads

The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis.

Audiol Neurootol 2017 23;22(4-5):205-217. Epub 2017 Nov 23.

Department of Otolaryngology - Head and Neck Surgery, Northwestern University, Chicago, IL, USA.

Background: A rare subset of sarcoidosis, neurosarcoidosis, is reported to occur in 5-7% of sarcoid patients and can manifest in a variety of ways. The most common are facial paralysis and optic neuritis, less commonly causing cochleovestibulopathy, blindness, anosmia, and other cranial nerve (CN) palsies. The sensory deficit may be severe and psychiatric symptoms may result from the effects of the disease or steroid treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000481681DOI Listing
November 2017
25 Reads

A case of relapsing polychondritis mimicking lung cancer.

Tuberk Toraks 2017 Sep;65(3):245-248

Division of Nucleer Medicine, Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Relapsing polychondritis (RP) is a rare autoimmune disease, characterized by episodic inflammatory attacks on cartilaginous tissue. Elastic cartilage of the ears and nose, hyaline cartilage of the peripheral joints, vertebral fibrocartilage, tracheobronchial cartilage, and tissues rich in proteoglycan such as those in the eyes, heart, blood vessels, and inner ear are more likely to be affected. A 35-year-old male presented with complaints of hoarseness, tinnitus and dyspnea for 19 years, with a history of several diagnostic and therapeutic interventions for laryngeal and respiratory tract. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5578/tt.46474DOI Listing
September 2017
9 Reads

The Clinician Faced With Anticochlear Antibodies: What to Do With Them?

J Clin Rheumatol 2018 Apr;24(3):113-115

From the Systemic Autoimmune Diseases Group; Facultad de Medicina, Universidad de la República; Médica Uruguaya Corporación de Asistencia Médica (MUCAM), Montevideo, Uruguay.

Background: Autoimmune inner ear disease as a cause of sensorineural hearing loss is a poorly understood entity. Thus, the role of anticochlear antibodies (ACLAs) in clinical management is still not well established.

Objective: The aims of this study were to describe the use of ACLAs in our clinical setting and to understand the clinicians' therapeutic approach in these cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000000609DOI Listing
April 2018
5 Reads

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease.

Audiol Neurootol 2017 28;22(3):190-195. Epub 2017 Oct 28.

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000481426DOI Listing
July 2018
10 Reads

The Etiological Relationship Between Migraine and Sudden Hearing Loss.

Otol Neurotol 2017 12;38(10):1411-1414

*Izmir Tepecik Education and Research Hospital Neurology Clinic †Izmir Tepecik Education and Research Hospital Head and Neck Surgery Clinic, Izmir ‡Adiyaman University Education and Research Hospital Head and Neck Surgery Clinic, Adiyaman, Turkey.

Objectives: To investigate the relationship between sudden sensorineural hearing loss (SSNHL) and migraine, assess the prevalence of migraine in patients with idiopathic SSNHL, and determine a possible common vascular etiopathogenesis for migraine and SSNHL.

Study Design: Prospective cohort study.

Setting: Tertiary referral center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAO.0000000000001617DOI Listing
December 2017
10 Reads

Analysis of audiometric relapse-free survival in patients with immune-mediated hearing loss exclusively treated with corticosteroids.

Acta Otorrinolaringol Esp 2018 Jul - Aug;69(4):214-218. Epub 2017 Oct 13.

Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España.

Objective: To describe the results in terms of audiometric relapse-free survival and relapse rate in immunomediated hearing loss patients treated exclusively with corticosteroids.

Method: Retrospective study of patients with audiometric relapses, monitored from 1995 to 2014, in two centres of the Community of Madrid.

Results: We evaluated 31 patients with a mean age of 48. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otorri.2017.08.004DOI Listing
April 2019
7 Reads

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy.

Pharmacotherapy 2017 12;37(12):1600-1616

Department of Pharmacy Practice & Science, College of Pharmacy, University of Arizona, Tucson, Arizona.

Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric assessment in order to categorize the hearing loss as conductive, sensorineural, or mixed. Sudden sensorineural hearing loss and autoimmune inner ear disease are acute and subacute forms of sensorineural hypoacusia most likely to be reversed with prompt pharmacological intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2044DOI Listing
December 2017
31 Reads

[Vitiligo revealing Vogt -Koyanagi-Harada disease].

Pan Afr Med J 2017 24;27:220. Epub 2017 Jul 24.

Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2017.27.220.11656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622831PMC
October 2017
24 Reads

Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging.

PLoS One 2017 4;12(10):e0186038. Epub 2017 Oct 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.

Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627945PMC
November 2017
17 Reads

Mycoplasmas: Brain invaders?

Res Vet Sci 2017 Aug 5;113:56-61. Epub 2017 Sep 5.

The Oaks, Nutshell Lane, Upper Hale, Farnham, Surrey GU9 0HG, UK. Electronic address:

Mycoplasmas of humans and animals are usually associated with respiratory, autoimmune, genital and joint diseases. Human mycoplasmas have also been known to affect the brain. Severe central nervous system (CNS) diseases, such as encephalitis, have been linked to Mycoplasma pneumoniae and ureaplasma infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rvsc.2017.09.006DOI Listing
August 2017
8 Reads

Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions.

J Neurol 2017 Oct 6;264(10):2119-2129. Epub 2017 Sep 6.

Institute of Clinical Neuroscience, Royal Prince Alfred Hospital, Missenden Road, Sydney, NSW 2050, Australia.

The medial longitudinal fasciculus (MLF) is the final common pathway for all conjugate adducting horizontal eye movements, as well as for the vertical-torsional vestibulo-ocular reflex (VOR). MLF lesion causes adduction paresis of ipsilesional (adducting) eye with dissociated nystagmus of contralesional (abducting) eye-the well-known clinical syndrome of internuclear ophthalmoplegia (INO). We measured the VOR stimulation and also any catch-up saccades, from individual semicircular canal (SCC) evoked by the head impulse test (HIT), using head and binocular 3-dimensional scleral search coils in 27 multiple sclerosis (MS) patients, 8 with unilateral, 19 with bilateral INO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-017-8607-8DOI Listing
October 2017
27 Reads

Hearing status in patients with rheumatoid arthritis.

J Laryngol Otol 2017 Oct 15;131(10):895-899. Epub 2017 Aug 15.

ENT and Head and Neck Research Center and Department,Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.

Objective: Rheumatoid arthritis is thought to induce conductive hearing loss and/or sensorineural hearing loss. This study evaluated the function of the middle ear and cochlea, and the related factors.

Methods: Pure tone audiometry, speech reception thresholds, speech discrimination scores, tympanometry, acoustic reflexes, and distortion product otoacoustic emissions were assessed in rheumatoid arthritis patients and healthy volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022215117001670DOI Listing
October 2017
10 Reads

Evaluation of ototoxicity of intratympanic administration of Methotrexate in rats.

Int J Pediatr Otorhinolaryngol 2017 Sep 4;100:132-136. Epub 2017 Jul 4.

Istanbul Medipol University, Faculty of Medicine, Restorative and Regenerative Research Center Istanbul, Turkey.

Objective: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear.

Methods: This study was planned as an animal study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2017.06.035DOI Listing
September 2017
7 Reads

[Cerebral vasculitis, a diagnostic labyrinth].

Ned Tijdschr Geneeskd 2017 ;161:D1148

Universitair Medisch Centrum Groningen, Groningen.

- A diagnosis of cerebral vasculitis is frequently considered in patients with new or progressive neurological symptoms for which there is no other explanation.- A clinician considering a diagnosis of cerebral vasculitis should be well aware of alternative diagnoses, since these are generally more common.- Several consecutive examinations are required for diagnosing cerebral vasculitis, because there is no diagnostic procedure that is highly sensitive as well as highly specific. Read More

View Article

Download full-text PDF

Source
June 2018
5 Reads

The Balance of Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Autoimmune Inner Ear Disease Patients.

J Interferon Cytokine Res 2017 08 11;37(8):354-361. Epub 2017 Jul 11.

1 Department of Otolaryngology, The Feinstein Institute for Medical Research , Manhasset, New York.

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the control or perpetuation of inflammation in corticosteroid-responsive (RES) and corticosteroid-resistant (NR) autoimmune inner ear disease (AIED) patients. In the present study, we observed that plasma from AIED patients exhibited greater levels of TIMP-1 values compared with normal healthy controls. Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/jir.2017.0053
Publisher Site
http://dx.doi.org/10.1089/jir.2017.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564044PMC
August 2017
3 Reads

Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis.

Clin Immunol 2017 10 23;183:24-35. Epub 2017 Jun 23.

Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea; The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Sudden sensorineural hearing loss (S-SNHL) is an inner ear disorder with an abrupt hearing loss occurring <3days. The pathologic mechanism of the disease remains unclear, although autoimmunity has been regarded as one of the suggested causes, especially in bilateral form. In this study, we aimed to provide evidence for the involvement of autoimmunity in bilateral S-SNHL using proteomic approaches such as ProtoArray®, western blotting, immunoprecipitation, and liquid column mass spectrometry for mass screening of candidate antigens and autoantibodies based on the hypothesis that multiple autoantibodies and target antigens must exist in order for autoimmune bilateral S-SNHL to develop. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.06.008DOI Listing
October 2017
34 Reads