930 results match your criteria Inner Ear Autoimmune Disease


Allergy, Immunotherapy, and Alternative Treatments for Dizziness.

Otolaryngol Clin North Am 2021 Jul 20. Epub 2021 Jul 20.

Jackson Ear Clinic, 290 East Layfair Drive, Flowood, MS 39232, USA.

Allergic reactions may result in central symptoms of dizziness, including nonspecific chronic imbalance, Meniere's disease, and autoimmune inner ear disease. Excepting first-generation antihistamines, and short-term use of steroids, most pharmacotherapies used to treat allergic rhinitis have limited benefit in treating allergically induced or related dizziness. Allergy immunotherapy and/or an elimination diet for diagnosed food allergies have been found to be effective treatments. Read More

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Otologic Manifestations After COVID-19 Vaccination: The House Ear Clinic Experience.

Otol Neurotol 2021 Jul 9. Epub 2021 Jul 9.

House Clinic, Los Angeles, California.

Objective: With the increasing numbers of COVID-19 vaccinations available there are some reports of new onset of otologic symptoms. We present our experience in recently vaccinated patients over a 30-day time frame.

Study Design: Retrospective chart review. Read More

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Immune-Mediated Sensorineural Hearing Loss in the Pediatric Population.

Otolaryngol Head Neck Surg 2021 Jul 13:1945998211028796. Epub 2021 Jul 13.

Department of Otolaryngology, Hofstra-Northwell School of Medicine, New Hyde Park, New York, USA.

A case series with chart review of pediatric patients with immune-mediated sensorineural hearing loss, including sudden sensorineural hearing loss and autoimmune-mediated hearing loss, was performed. Ninety-eight patients with sensorineural hearing loss were reviewed, and 41 patients met the inclusion criteria, which included corticosteroid therapy for a decline in sensorineural hearing. The primary outcome was the corticosteroid response rate: 61% of patients responded. Read More

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OTOACOUSTIC EMISSION AND AUDITORY BRAINSTEM RESPONSE IN PATIENTS WITH AUTOIMMUNE THYROIDITIS.

Georgian Med News 2021 May(314):42-48

Bogomolets National Medical University, Department of Оtorhinolaryngology, Kiev, Ukraine.

The function of the outer hair cells (OHC) in patients with euthyroid autoimmune thyroiditis (AIT) was investigated in frequency range of 1000 - 8000 Hz. Our aim was to measured of AIT factors influence on auditory function in patients with no subjective sensations of hearing loss. For this study we selected patients with euthyroid AIT. Read More

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Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière's Disease.

Front Neurol 2021 16;12:646928. Epub 2021 Jun 16.

Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, United States.

Menière's disease microRNA (miRNA) profiles are unique and are reflected in the perilymph and serum of patients. Development of effective biomarkers for Menière's disease are needed. miRNAs are small RNA sequences that downregulate mRNA translation and play a significant role in a variety of disease states, ultimately making them a promising biomarker. Read More

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The use of gene-modified bone marrow mesenchymal stem cells for cochlear cell therapy.

Transpl Immunol 2021 Jun 29;68:101433. Epub 2021 Jun 29.

Department of Otolaryngology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The aim of this study was to investigate the potential of using bone marrow mesenchymal stem cells (BMSCs) for treatment of inflammation and autoimmune sensorineural hearing loss.

Methods: Fifty-five immunized guinea pigs were divided into five groups. Group A received BMSCs expressing IL-4, group B received BMSCs expressing an empty carrier vector, group C received recombinant lentivirus expressing IL-4, group D received recombinant lentivirus expressing an empty carrier vector, and group E received phosphate-buffered saline. Read More

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Hearing loss in inner ear and systemic autoimmune disease: A systematic review of post-cochlear implantation outcomes.

Laryngoscope Investig Otolaryngol 2021 Jun 4;6(3):469-487. Epub 2021 May 4.

University Hospitals Birmingham NHS Foundation Trust Birmingham UK.

Objectives: To assess outcomes following cochlear implantation (CI) in patients with hearing loss secondary to primary or secondary autoimmune inner ear disease (AIED).

Methods: A systematic review and narrative synthesis was completed according to PRISMA guidelines. Databases searched included MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Collection, and ClinicalTrials. Read More

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Biologics for Immune-Mediated Sensorineural Hearing Loss.

Otolaryngol Clin North Am 2021 Aug 10;54(4):803-813. Epub 2021 Jun 10.

Department of Otolaryngology, Zucker School of Medicine at Hofstra-Northwell, Hearing and Speech Center, 430 Lakeville Road, New Hyde Park, NY 11040, USA.

Immune-mediated hearing losses include autoimmune inner ear disease, sudden sensorineural hearing loss, and Meniere's disease. Standard therapy for an acute decline in hearing is timely use of corticosteroids. Although 60% to 70% of patients are initially corticosteroid-responsive, that responsiveness is lost over time. Read More

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Long-term (16-26 years) follow-up outcome of steroid therapy in refractory autoimmune sensorineural hearing loss.

J Autoimmun 2021 Jul 25;121:102664. Epub 2021 May 25.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Autoimmune sensorineural hearing loss (ASHL) is a rare disease of uncertain etiology, with no established treatment strategy. The duration of morbidity is increased in refractory cases; and therefore, the preservation of hearing and the prevention of adverse effects with steroid therapy are serious long term issues to consider. Long-term follow up of patients treated for ASHL was performed retrospectively in order to elucidate the pathogenesis of ASHL, evaluate the consequences of steroid therapy, and determine a promising treatment course. Read More

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miRNA Landscape in Pathogenesis and Treatment of Vogt-Koyanagi-Harada Disease.

Front Cell Dev Biol 2021 10;9:658514. Epub 2021 May 10.

Laboratory of Ocular and Systemic Autoimmune Diseases, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

miRNAs, one of the members of the noncoding RNA family, are regulators of gene expression in inflammatory and autoimmune diseases. Changes in miRNA pool expression have been associated with differentiation of CD4 T cells toward an inflammatory phenotype and with loss of self-tolerance in autoimmune diseases. Vogt-Koyanagi-Harada (VKH) disease is a chronic multisystemic pathology, affecting the uvea, inner ear, central nervous system, and skin. Read More

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The Correlation of Clinical Corticosteroid Responsiveness With Expression of IL-6 in Peripheral Blood Immune Cells (PBMC) in Patients With Autoimmune Inner Ear Disease (AIED).

Otol Neurotol 2021 May 21. Epub 2021 May 21.

Department of Otolaryngology, Zucker School of Medicine at Hofstra/Northwell, Feinstein Institute for Medical Research, Manhasset, New York Department of Otorhinolaryngology, Albert Einstein College of Medicine, Bronx, New York Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Feinstein Institute for Medical Research, Manhasset, New York.

Hypothesis: Autoimmune inner ear disease (AIED) patients will differentially express interleukin (IL)-6 based on corticosteroid responsiveness.

Background: AIED is characterized by periods of acute sensorineural hearing loss (SNHL). In a majority of patients corticosteroid responsiveness is lost over time. Read More

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Granulomatosis with Polyangiitis as a Cause of Sudden-Onset Bilateral Sensorineural Hearing Loss: Case Report and Recommendations for Initial Assessment.

Case Rep Otolaryngol 2021 20;2021:6632344. Epub 2021 Apr 20.

University of New Mexico School of Medicine, Department of Surgery: Division of Otolaryngology and Head and Neck Surgery, Albuquerque, NM 87106, USA.

Granulomatosis with polyangiitis (GPA) is a severe systemic vasculitis that commonly affects the paranasal sinuses, upper and lower respiratory tracts, and kidneys. GPA has also been associated with sensorineural hearing loss (SNHL), through inflammation of the cochlear apparatus. Early recognition, diagnostic laboratory evaluation, and appropriate treatment are essential to improve outcomes and achieve remission for patients with GPA. Read More

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Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction.

Front Med (Lausanne) 2021 13;8:589969. Epub 2021 Apr 13.

Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China.

To investigate the clinical characteristics of patients with dizziness/vertigo accompanied by loss of the posterior canal(s) (LPC). Clinical data of 23 patients with LPC were collected. We determined video-head-impulse test (vHIT) gains of all six semicircular canals and correlated vHIT findings with other vestibulo-cochlear tests, including caloric test, ocular and cervical vestibular-evoked myogenic potentials (oVEMP, cVEMP), pure tone audiometry (PTA), and analyzed the differences in clinical manifestations of patients with LPC with different etiologies. Read More

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Sensorineural Hearing Loss and Systemic Autoimmune Disease: The Experience of a Systemic Immune-Mediated Diseases Unit.

Cureus 2021 Mar 24;13(3):e14075. Epub 2021 Mar 24.

Systemic Immune-Mediated Diseases Unit, Department of Internal Medicine IV, Hospital Prof. Doutor Fernando Fonseca, Amadora, PRT.

Background Autoimmune inner ear disease (AIED) represents less than 1% of all cases of sensorineural hearing loss (SNHL) but its frequency may be underestimated due to lack of specific clinical and laboratory criteria. AIED can be associated with a systemic autoimmune disease (SAID) in 15%-30% of the cases. The objective of the present study was to characterize the clinical and prognostic factors of a cohort of patients with AIED. Read More

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Comprehensive Clinical Assessment of Vestibular Function in Multiple Sclerosis.

J Neurol Phys Ther 2021 07;45(3):228-234

Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham (G.D.C., J.B.C., R.W.M.); and Medical Scientist Training Program, School of Medicine, University of Alabama at Birmingham, Birmingham (G.D.C.).

Background And Purpose: Balance disorders and dizziness are common in people with multiple sclerosis (MS), suggesting dysfunction of the vestibular system. Evaluating how people with MS perform on objective clinical vestibular tools will help broaden understanding of vestibular function in MS. This cross-sectional study's goal was to complete a robust battery of vestibular-ocular reflex (VOR), dynamic visual acuity (DVA), subjective visual vertical (SVV), and cervical and ocular vestibular-evoked myogenic potential (c/oVEMP) tests in people with and without MS. Read More

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Evaluation of inner ear and hearing functions in lichen planus patients.

J Cosmet Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Dermatology, Harran University Faculty of Medicine, Sanliurfa, Turkey.

Background: Lichen planus (LP), which affects skin, nails, hair, and mucosal surfaces, is a chronic, autoimmune, and inflammatory disease, and autoimmune diseases may affect the inner ear.

Aims: This study aims to investigate hearing and inner ear functions of the LP patients.

Patients/methods: The present study was formed by 49 patients who were clinically and histopathologically diagnosed with LP and did not receive any treatment. Read More

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Epley manoeuvre for posterior semicircular canal benign paroxysmal positional vertigo in people with multiple sclerosis: protocol of a randomised controlled trial.

BMJ Open 2021 03 18;11(3):e046510. Epub 2021 Mar 18.

Department of Physiotherapy, University of Seville, Sevilla, Spain.

Introduction: Vestibular disorders in multiple sclerosis (MS) could have central or peripheral origin. Although the central aetiology is the most expected in MS, peripheral damage is also significant in this disease. The most prevalent effect of vestibular peripheral damage is benign paroxysmal positional vertigo (BPPV). Read More

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Association of systemic lupus erythematosus with hearing loss: a systemic review and meta-analysis.

Rheumatol Int 2021 Apr 3;41(4):681-689. Epub 2021 Feb 3.

Department of Otorhinolaryngology, 401 General Military Hospital of Athens, Athens, Greece.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can affect virtually any organ, including middle and/or inner ear. The objective of the current systematic review and meta-analysis was to investigate the association of SLE with the different subtypes of hearing loss. This systematic review and meta-analysis was conducted in agreement with the PRISMA guidelines. Read More

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There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata.

Int J Clin Pract 2021 May 27;75(5):e14040. Epub 2021 Jan 27.

Department of Audiology, Karabuk University, Karabuk, Turkey.

Purpose: Follicular melanocytes are known to be damaged in alopecia areata (AA). However, it is not clear whether melanocytes are the primary target of autoimmunity and whether melanocytes in the inner ear are affected. This study aimed to detect possible cochlear and/or vestibular melanocyte damage in AA patients. Read More

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The Pathogenesis of secondary forms of Autoimmune Inner Ear Disease (AIED): advancing beyond the audiogram data.

Expert Rev Clin Immunol 2021 Mar 22;17(3):233-246. Epub 2021 Mar 22.

ENT and Audiology Department, University Hospital of Ferrara, Ferrara, Italy.

Introduction: Autoimmune Inner Ear Disease (AIED) can be of a primary or secondary type. To date, a clear pathogenesis of the disease is still not available. Focusing on the secondary forms of AIED, the aim of this review is to (i) assess and describe the hearing involvement in patients affected by autoimmune diseases, (ii) describe the possible association between clinical features (among serological/laboratory data and disease activity/duration) and hearing impairment, (iii) show evidence connecting the AIED types with various etiopathogenetic mechanisms. Read More

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'Cochlear-type' hearing loss as part of aquaporin-4 neuromyelitis optica spectrum disorder.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Bodleian Library, University of Oxford, Oxford, UK

Neuromyelitis optica spectrum disorder is an inflammatory autoimmune central nervous system condition caused in the majority of cases by aquaporin-4 IgG antibodies. Aquaporin-4 is expressed in the cochlear and vestibular nuclei regions in the brainstem and a handful of cases of retro-cochlear type hearing loss have been documented in the literature. Aquaporin-4 has also been reported within the organ of Corti and the cristae and maculae of the vestibular apparatus. Read More

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January 2021

Autoimmune inner ear disease: A systematic review of management.

Laryngoscope Investig Otolaryngol 2020 Dec 28;5(6):1217-1226. Epub 2020 Nov 28.

Department of Otolaryngology-Head and Neck Surgery University of Florida Gainesville Florida USA.

Objectives: The study systematically reviewed the existing literature on the management of autoimmune inner ear disease (AIED).

Study Design: Systematic review.

Methods: We performed a literature search of Embase, NCBI, Cochrane, and Web of Science databases from April 1990 to April 2020. Read More

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December 2020

Autoimmune Inner Ear Disease among Patients with Selective IgA Deficiency.

Audiol Neurootol 2021 11;26(2):127-134. Epub 2020 Dec 11.

School of Public Health, Tel-Aviv University, Tel Aviv, Israel.

Objectives: Autoimmune inner ear disease (AIED) is a distinct clinical entity from sudden sensorineural hearing loss. The purpose of this study was to investigate the clinical characteristics of AIED in patients with selective IgA deficiency (sIgAD).

Materials And Methods: This retrospective observational study was based on data from the Leumit Healthcare Services database in Israel. Read More

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Audiological findings in the Vogt-Koyanagi-Harada Syndrome.

Codas 2020 9;32(5):e20190183. Epub 2020 Nov 9.

Faculdade de Odontologia de Bauru (FOB)- Universidade de São Paulo, Bauru, SP, Brazil.

The Vogt-Koyanagi-Harada syndrome (VKHS) is a rare, multisystemic and autoimmune disease. The syndrome mainly affects the eyes, followed by bilateral chronic panuveitis, however, the syndrome may also affect the melanocytes tissues, for example, the eyes, inner ear, meninges and skin. The syndrome origin mechanism is not yet completely known. Read More

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November 2020

Assessment of Hearing Function in Children with Inflammatory Bowel Disease.

J Int Adv Otol 2020 Dec;16(3):362-366

Department of Otolaryngology, University of Health Sciences İstanbul Training and Research Hospital, Istanbul, Turkey.

Objectives: Inflammatory bowel disease (IBD), a chronic pathology that affects many organ systems, appears after dysregulated immune response in genetically predisposed patients. Inner organ involvement has been shown in various autoimmune diseases because of its immunosensitivity. In this study, we aimed at showing sensorineural hearing loss (SNHL) as a result of possible subclinical inflammation in patients with IBD during the remission period. Read More

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December 2020

Benign Paroxysmal Positional Vertigo After Oral and Maxillofacial Surgery: Our Experience and Review of Literature.

J Maxillofac Oral Surg 2020 Dec 22;19(4):527-531. Epub 2019 Mar 22.

Otolaryngology Unit, Department of Medicine, Surgery and Odontoiatrics, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno Italy.

Objectives: The aim of our study is to evaluate the influence of patient risk factors and the length of surgical time on the onset of BPPV (benign paroxysmal positional vertigo) and suggest surgical and clinical strategies to prevent this rare complication.

Method: Our retrospective study analyzes that, in 2 years, 281 patients, divided into three groups, underwent wisdom teeth extraction, sinus lift elevation and orthognathic surgery, at the Oral and Maxillofacial Department of the University of Naples "Federico II."

Results: Twenty-one patients presented postoperative BPPV. Read More

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December 2020

Unilateral autoimmune inner ear disease in a patient with lung cancer treated with nivolumab.

Oxf Med Case Reports 2020 Sep 22;2020(9):omaa077. Epub 2020 Sep 22.

Queensland University of Technology, Faculty of Health, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Cancer and Ageing Research Program, Brisbane, Australia.

A 69-year-old male presented with early stage non-small cell lung cancer in 2016. The tumor was resected; however, the patient experienced recurrence 2 years later and subsequently received paclitaxel/carboplatin concurrently with radiotherapy. Within weeks of completing this treatment, he developed a symptomatic pancoast tumor secondary to disease progression and commenced second line nivolumab. Read More

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September 2020

[Immune-mediated sensorineural hearing loss: prevalence and treatment strategies].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jul;34(7):663-667

Autoimmune sensorineural hearing loss is a rare clinical entity which accounting for less than 1% in all cases with hearing loss. The prevalence of hearing loss in immune-mediated inner ear diseases, as shown in case reports or single-center statistics, varies widely. We reviewed the current literatures on the association between sensorineural hearing loss and autoimmune diseases, focused on the prevalence of hearing loss in different autoimmune diseases, treatments and challenges. Read More

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[Advances in diagnosis and therapies of immune-mediated inner ear diseases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Mar;34(3):276-281

Immune-Mediated Inner Ear Diseases(IMIED) is one of the curable sensorineural hearing loss caused by abnormal immune response, which may be primary inner ear diseases or associated with systemic autoimmune diseases. Since the complex differential diagnosis and no reliable diagnostic tests, the early identification of IMIED was extremely tricky. The treatment still mainly depends on glucocorticoid, but as researchs move along, directing at different pathogenesis, more and more therapies have been proposed. Read More

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