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AIDS 2021 Jun;35(7):1073-1081

Université de Paris, Faculté de Médecine.

Objective: The aim of this study was to evaluate the cumulative live birth rate in women undergoing in-vitro fertilization/intracytoplasmic-sperm-injection (IVF/ICSI) according to the type of chronic viral infection [HIV, hepatitis-B virus (HBV) and hepatitis-C virus (HCV)].

Design: A cohort study.

Setting: A tertiary-care university hospital. Read More

Nanotechnology 2021 May 4. Epub 2021 May 4.

Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Plant Development, Beijing, CHINA.

Pterostilbene (PTE) is known as resveratrol of the next generation and it has attracted extensive attention in recent years. PTE can inhibit the growth of a variety of tumor cells. To overcome the problem of insolubility, PTE was loaded into nanoparticles (NPs) by anti-solvent precipitation technique using soybean lecithin (SPC) and D-α-tocopheryl polyethylene glycol succinate (TPGS) as stabilizers. Read More

Foot (Edinb) 2021 Apr 20;47:101805. Epub 2021 Apr 20.

East Kent Hospitals NHS University Foundation Trust, Ashford, United Kingdom.

Background: There has been no consensus regarding the treatment of osteochondral lesions of the talus, there has been many attempts to formulate a treatment pathway, with multiple proposed modalities and adjuncts used.

Objectives: The aim of this paper was to investigate the evidence published in the recent history, identify the relevant papers, review and summarize the findings, to help clarify the available operative treatment options and their respective efficacies based on the level of evidence provided.

Study Design & Methods: A literature search through electronic databases MEDLINE and EMBASE was done, these databases were screened for publications and papers form June 2004 to June 2019. Read More

Food Chem 2021 Apr 23;359:129932. Epub 2021 Apr 23.

Normandie Univ, Laboratoire SMS-EA3233, UNIROUEN, FR3038, Place Emile Blondel, F-76821, Mont-Saint-Aignan Cedex, France. Electronic address:

Performances of multiresidue analysis of one hundred of pesticides and contaminants, using GC-Q-Orbitrap method in full scan mode were compared to those obtained with GC-triple-quadrupole method in multiple reaction monitoring mode. In terms of sensitivity, 86% of molecules exhibited lower limit of detection values using GC-Q-Orbitrap than using GC-triple-quadrupole. For the GC-Q-Orbitrap method, more than 85% of the pesticides and contaminants showed good recovery [70-120%] in wheat samples, with relative standard deviation values < 20%. Read More

Biomed Pharmacother 2021 May 1;139:111670. Epub 2021 May 1.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address:

Cisplatin (Cis) is an effective cancer therapy commonly employed in many therapeutic regimens. However, treatment regimens that contain either a high dose or cumulative doses of Cis could trigger liver damage. A unique study demonstrated that captopril (Cap) protects against Cis-induced liver toxicity, but only some liver function enzymes and some antioxidant enzymes were investigated in that study. Read More

Photodiagnosis Photodyn Ther 2021 May 1:102307. Epub 2021 May 1.

Agri Ibrahim Cecen University Faculty of Medicine, Department of Ophthalmology, Agri, Turkey.

Background: Evaluation of anatomical and functional recovery of the retina after aflibercept therapy in neovascular age-related macular degeneration MATERIALS AND METHODS: This prospective study enrolled 33 eyes of 33 naive age-related macular degeneration patients with an average age of 69 (55-82) years. Following a thorough ophthalmological examination, baseline color fundus photography, optical coherence tomography and fluorescein angiography were used to assess the angiographic characteristics and classification of the lesions. Multifocal electroretinography and microperimetry were recorded. Read More

Neurobiol Dis 2021 May 1:105384. Epub 2021 May 1.

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background CD47, a glycoprotein on red blood cell membranes, inhibits phagocytosis via interaction with signal regulatory protein α on phagocytes. Our previous research has demonstrated that blocking CD47 accelerates hematoma clearance and reduces brain injury after intracerebral hemorrhage. The current study investigated whether phagocytosis or erythrocyte CD47 impacts hematoma resolution and hydrocephalus development after intraventricular hemorrhage (IVH). Read More

Behav Brain Res 2021 May 1:113339. Epub 2021 May 1.

Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, People's Republic of China. Electronic address:

Dopamine (DA) in the striatum is essential to influence motor behavior and may lead to movement impairment in Parkinson's disease (PD). The present study examined the different functions of the DA D1 receptor (D1R) and DA D2 receptor (D2R) by intrastriatal injection of the D1R agonist SKF38393 and the D2R agonist quinpirole in 6-hydroxydopamine (6-OHDA)-lesioned and control rats. All rats separately underwent dose-response behavior testing for SKF38393 (0, 0. Read More

Neurosci Lett 2021 May 1:135939. Epub 2021 May 1.

Physiology program, Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hatyai Campus, Hatyai, Songkhla, 90110, Thailand; Biosignal Research Center for Health, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla, 90112, Thailand. Electronic address:

The basolateral amygdala (BLA) plays a crucial role in conditioned place preference (CPP) for addictive drugs. However, neural signaling associated with methamphetamine (METH) craving and seeking remained to be investigated. This study characterized local field potential (LFP) oscillatory patterns in the BLA and conditioned place preference induced by METH-related context. Read More

Med Ultrason 2021 Apr 22. Epub 2021 Apr 22.

Department of Anaesthesia Cork University Hospital Cork, Ireland.

Aim: Retrolaminar block (RB) is known to confer chest wall analgesia but, its mechanism has not been established. Our primary objective was to determine if the spread of injectate following RB extends to the paravertebral space (PVS). Second-ary objectives were to determine the predefined anatomical areas and nervous tissues contacted by injectate; the effect of volume on spread; and the extent to which experts can predict PVS spread based on examination of US videos of the injection. Read More

PLoS One 2021 4;16(5):e0248840. Epub 2021 May 4.

School of Mechanics Science & Engineering, Northeast Petroleum University, Daqing, Heilongjiang, China.

The system efficiency of pumping units in the middle and late stages of oil recovery is characterized by several factors, complex data and poor regulation. Further, the main control factors that affect system efficiency in different blocks vary greatly; therefore, it is necessary to obtain the block characteristics to effectively improve system efficiency. The k-means algorithm is simple and efficient, but it assumes that all factors have the same amount of influence on the output value. Read More

JCI Insight 2021 May 4. Epub 2021 May 4.

Division of Pulmonary and Critical Care, Cedars-Sinai Medical Center, Los Angeles, United States of America.

Idiopathic Pulmonary Fibrosis (IPF) is characterized by aberrant repair that diminishes lung function via mechanisms that remain poorly understood. C-C chemokine receptor (CCR10) and its ligand, CCL28, were both elevated in IPF compared with normal donors. CCR10 was highly expressed by various cells from IPF lungs, most notably stage-specific embryonic antigen (SSEA)-4+ mesenchymal progenitor cells (MPCs). Read More

Neurosignals 2021 May;29(S1):1-7

Department of Ophthalmology, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Background/aims: Intravitreal rituximab is an off-label treatment option for primary vitreoretinal lymphoma (PVRL). The objective of this study was to monitor the therapeutic response and safety profile of intravitreal rituximab in a cohort of PVRL patients.

Methods: In this retrospective, uncontrolled, open label, multicentre study, 20 eyes from 15 consecutive patients diagnosed with PRVL received at least one intravitreal injection of 1mg in 0. Read More

J Diabetes Investig 2021 May 4. Epub 2021 May 4.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.

Introduction: Treatments for type 2 diabetes (T2D) targeting baseline glucose levels but not postprandial glucose can result in normalized fasting blood glucose but suboptimal overall glycemic control (high glycated hemoglobin); residual hyperglycemia. In Japanese patients with T2D the predominant pathophysiology is lower insulin secretory capacity, and residual hyperglycemia is common with basal insulin treatment. Single-injection, fixed-ratio combinations of glucagon-like peptide-1 receptor agonists and basal insulin have been developed. Read More

J Sep Sci 2021 May 4. Epub 2021 May 4.

Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, Berlin, 14195, Germany.

In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. Building on these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Read More

Skeletal Radiol 2021 May 4. Epub 2021 May 4.

Medscanlagos Radiology, Rua Manoel Francisco Valentim, 57, Cabo Frio, RJ, 28906220, Brazil.

Vaccination injection site adverse reactions are usually mild and transient, and post-vaccination musculoskeletal symptoms, such as myalgia and arthralgia, are very common. Shoulder injury related to vaccine administration (SIRVA), defined as shoulder pain and limited range of motion occurring after the administration of a vaccine intended for intramuscular administration in the upper arm, is a well-established condition in the medical literature, yet underreported. In such cases, subacromial-subdeltoid bursitis may occur, leading to shoulder dysfunction and ongoing pain. Read More

Toxicol Sci 2021 May 3. Epub 2021 May 3.

National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR 72079.

The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent genotoxin and human lung carcinogen; however, there are limited inhalation data for the toxicokinetics (TK) and genotoxicity of NNK in vivo. In the present study, a single dose of 5x10-5, 5x10-3, 0. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021053. Epub 2021 Apr 30.

Parma University Hospital.

A a 80-year-old male underwent routine transthoracic echocardiography the day after primary percutaneous revascularization procedure for ST-elevation myocardial infarction. When ultrasound contrast  was injected, regular contrast-enhancement of the left ventricle (LV) excluded the presence of thrombus. A second echocardiogram, performed four months later, showed a hyperechoic image in the LV apex, which was confirmed after contrast injection as a thrombus. Read More

J Matern Fetal Neonatal Med 2021 May 4:1-8. Epub 2021 May 4.

Division of Maternal Fetal Medicine, William Beaumont Health, Royal Oak, MI, USA.

Objective: To identify maternal second and third trimester urine metabolomic biomarkers for the detection of fetal congenital heart defects (CHDs).

Study Design: This was a prospective study. Metabolomic analysis of randomly collected maternal urine was performed, comparing pregnancies with isolated, non-syndromic CHDs versus unaffected controls. Read More

Nanotoxicology 2021 May 4:1-14. Epub 2021 May 4.

National Institute of Advanced Science and Technology (AIST), Tsukuba, Japan.

The present study compared the effects of two commonly-used dispersants, bovine serum albumin (BSA) and polyethylene glycol (PEG), on the biodistribution and toxicity of oxidized super-growth single-wall carbon nanotubes (oxSG) injected intravenously into mice over 3 months. About 1-2% of the injected dose (ID) of oxSG dispersed in BSA (oxSG-BSA) was present in the lungs at all time points. By contrast, about 15% of the ID of oxSG dispersed in PEG (oxSG-PEG) was present in the lungs at 1 day (D1), with accumulation decreasing to about 5% of the ID at 90 days (D90). Read More

J Cosmet Laser Ther 2021 May 4:1-7. Epub 2021 May 4.

Aesthetic Practitioner, Private Practice, Cheshire, UK.

OnabotulinumtoxinA injection can enhance the appearance of the eyes. This study evaluated the lifting effect of onabotulinumtoxinA treatment of the eye area. A retrospective, single-center audit of patients treated for glabellar and crow's feet rhytids was undertaken. Read More

Cutan Ocul Toxicol 2021 May 4:1-5. Epub 2021 May 4.

Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: The primary aim of the study was to investigate the effects of anti-vascular endothelial growth factor (VEGF) injections on the inner retinal layer anatomy of the lesion-free retina in eyes treated for neovascular age-related macular degeneration (nAMD). The secondary aim was to compare the changes of inner retinal layers in the lesion-free region of treated eyes with the same region of the untreated, fellow eyes and, thus, to elucidate any adverse effect of anti-VEGF treatments independently of 1-year aging changes.

Methods: This was a retrospective, longitudinal, case-control study of 50 eyes of 25 patients. Read More

Radiology 2021 May 4:203968. Epub 2021 May 4.

From the University of Lyon, National Institute of Applied Sciences of Lyon, University Claude Bernard Lyon 1, Jean Monnet University-Saint Etienne, French National Centre for Scientific Research, Institut national de la santé et de la recherche médicale, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Unité mixte de recherche 5220, U1206, F-69621, Lyon, France (S.A.S.M., M.S., V.T.L., R.D., L.B., P.C.D.); Departments of Radiology (S.A.S.M., T.G., L.B., P.C.D.) and Pathology (L.C.), Hospices Civils de Lyon, Lyon, France; Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (J.C.H., P.C.N., D.P.C.); Department of Radiology, Faculty of Medicine, Zagazig University, Egypt (R.D.); and Department of Rheumatology, Allergy, and Immunology, Yale University, New Haven, Conn (M.C.).

Background Macrophage burden is a major factor in the risk of atherosclerotic plaque rupture, and its evaluation remains challenging with molecular noninvasive imaging approaches. Photon-counting CT (PCCT) with k-edge imaging aims to allow for the specific detection of macrophages using gold nanoparticles. Purpose To perform k-edge imaging in combination with gold nanoparticles to detect and quantify the macrophage burden within the atherosclerotic aortas of rabbits. Read More

J Ocul Pharmacol Ther 2021 Apr 30. Epub 2021 Apr 30.

Department of Pediatric Surgery, King Abdullah Specialist Children's Hospital, Ministry of National Guards, Riyadh, Saudi Arabia.

To compare outcomes of diclofenac versus dexamethasone in patients after strabismus surgery. A systematic review and meta-analysis were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted on MEDLINE, EMBASE, EMCARE, CINAHL, and the Cochrane Central Register of Controlled Trials (CENTRAL). Read More

Plant Dis 2021 May 4. Epub 2021 May 4.

Universitat de Girona, 16738, Institute of Food and Agricultural Technology, Girona, Catalunya, Spain;

(Mill.) swingle is a highly invasive tree that has become established worldwide, especially in the Mediterranean Basin because of its good drought resistance. is included in the list of Invasive Alien Species of the EU, so measures for eradication and management are required. Read More

Cell Prolif 2021 May 4:e13041. Epub 2021 May 4.

Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.

Objectives: Myocardial infarction (MI) is the most predominant type of cardiovascular diseases with high mortality and morbidity. Stem cell therapy, especially cardiac progenitor cell therapy, has been proposed as a promising approach for cardiac regeneration and MI treatment. Previously, we have successfully generated cardiac progenitor-like cells, induced cardiosphere (iCS), via somatic reprogramming. Read More

Br J Haematol 2021 May 4. Epub 2021 May 4.

Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Beta-thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload. Hepcidin is under the negative control of transmembrane serine protease 6 (TMPRSS6) via cleavage of haemojuvelin (HJV), a co-receptor for the bone morphogenetic protein (BMP)-mothers against decapentaplegic homologue (SMAD) signalling pathway. Read More

J Exp Biol 2021 May 4. Epub 2021 May 4.

Department of Biology, Faculty of Science, Yamagata University, 990-8560 Yamagata, Japan.

The effects of dopamine on the agonistic behaviour of crayfish were analysed. When dopamine concentrations of 1 µM were injected into large crayfish, individuals were beaten by smaller opponents, despite their physical advantage. Injection of 10 µM dopamine into small animals increased their winning rate against larger opponents. Read More

Neurologist 2021 May 5;26(3):98-100. Epub 2021 May 5.

Department of Neuroscience, NYU Winthrop Hospital, Mineola, NY.

Introduction: This case demonstrates an underrecognized cause of posterior reversible encephalopathy syndrome (PRES).

Case Report: We report a 51-year-old male with a history of essential hypertension without preexisting renal impairment who presented with 3 days of occipital headache and convulsive status epilepticus in the setting of refractory hypertension. He had been receiving outpatient human recombinant erythropoietin injections for virally mediated bone marrow suppression, which worsened his baseline hypertension. Read More

J Postgrad Med 2021 Apr-Jun;67(2):67-74

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Aims: To evaluate the prevalence of metabolic syndrome (MS) and whole-body composition in patients with congenital hypogonadism and investigate the effects of replacement therapy with testosterone undecanoate on MS, insulin resistance (IR), and whole-body composition in subset of patients.

Methods: In a single arm prospective longitudinal intervention study, 33 patients with congenital hypogonadism, ages 20-39 years, were recruited and their parameters of MS, whole-body composition by DXA were compared with age and BMI matched healthy controls. In 21 patients, after 9 months we prospectively studied the effect (pre-post difference) of injection testosterone undecanoate (1,000 mg) replacement on MS, IR, and whole-body compositions. Read More