Eur J Pharm Biopharm 2016 Apr 11;101:126-36. Epub 2016 Feb 11.
Pharmbiotec GmbH, Saarland University, Campus C 2.2, 66123 Saarbrücken, Germany; Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus A 4.1, 66123 Saarbrücken, Germany; Helmholtz Centre for Infection Research and Helmholtz Institute for Pharmaceutical Research Saarland, Campus E 8.1, 66123 Saarbrücken, Germany.
The treatment of joint related diseases often involves direct intra-articular injections. For rational development of novel delivery systems with extended residence time in the joint, detailed understanding of transport and retention phenomena within the joint is mandatory. This work presents a systematic study on the in vitro permeation, penetration and accumulation of model polymers with differing charges and molecular weights in bovine joint tissue. Read More