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J Cosmet Dermatol 2020 Jun 5. Epub 2020 Jun 5.

All Saints Clinic, Double Bay, New South Wales, Australia.

Background: Tissue fillers are generally safe and well tolerated by patients. However, complications do occur, and may be very severe, such as intravascular injection (with occasional residual tissue loss, visual and neurological sequelae) and late nodularity and swelling. Methods to lessen the likelihood of complications have been the subject of much recent literature. Read More

J Cosmet Dermatol 2020 Jun 5. Epub 2020 Jun 5.

Grupo Pedro Jaén Dermatology Clinic, Madrid, Spain.

Background: a wide range of fillers are already available for facial rejuvenation. Most of them are based on the use of reticulated or non-reticulated hyaluronic acid.

Aims: the main objective of this study is to present the advantages, efficacy and safety profile of a new agarose gel filler without reticulating agents, for different facial areas. Read More

Aesthet Surg J 2020 May 29. Epub 2020 May 29.

Physicians, Department for Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian University Munich, Germany.

Background: Glabellar soft tissue filler injections have been shown to be associated with a high risk for causing injection related visual compromise.

Objectives: To identify the course of the superficial branch of the supratrochlear and of the deep branch of the supraorbital artery in relation to the ipsilateral vertical glabellar line and to test whether the artery is located in its depth.

Methods: 41 healthy volunteers with a mean age of 26. Read More

Aesthetic Plast Surg 2020 May 22. Epub 2020 May 22.

MD Codes Institute, Rua Santa Justina, 660 - cjs 121 e 124, Via Olímpia, Sao Paulo, SP, Brazil.

Background: Patients often seek aesthetic correction of facial deficiencies (e.g., lines and folds) that are rarely the underlying cause of dissatisfaction with their appearance. Read More

Plast Reconstr Surg Glob Open 2020 Apr 29;8(4):e2730. Epub 2020 Apr 29.

Batniji Facial Plastic Surgery, Newport Beach, Calif.

Background: Delayed-onset adverse reactions to hyaluronic acid (HA) fillers are uncommon but have received increased attention, particularly with regard to late-onset nodules. Globally, there is a need for comprehensive prevention and management strategies.

Methods: Experts with clinical practices in diverse regions of the world and extensive experience in managing complications related to HA fillers convened to propose and evaluate approaches to prevent delayed-onset adverse reactions after HA filler administration and manage late-onset nodules. Read More

J Cosmet Dermatol 2020 May 17. Epub 2020 May 17.

Department for Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian University Munich, Munich, Germany.

Objective: The most promising facial region for inducing pan-facial effects is the temporal region. The temple displays signs of facial aging itself which include temporal volume loss and increased visibility of the temporal crest, the temporal vasculature, the lateral orbital rim, and the upper zygomatic arch. The objective of this article is to provide a detailed review of temple anatomy pertaining to routinely performed temporal injection techniques, their expected esthetic outcomes as well as the intendant advantages, disadvantages, and procedure pearls. Read More

Dermatol Ther 2020 May 8:e13539. Epub 2020 May 8.

Department of plastic surgery, Amsterdam University Medical Center, Manitoba, Amsterdam, Netherlands.

Ann Transl Med 2020 Mar;8(6):362

ORL Department, Ludwig-Maximilians University Munich, Munich, Germany.

Background: The search for effectiveness and safety in the use of dermal fillers, is an ongoing challenge for aesthetic physicians, plastic surgeons and the science of bioengineering. Understanding the variety of characteristics, capabilities, advantages and disadvantages of available injectables is essential to reduce complication rates and achieve satisfying aesthetic and functional results.

Methods: Algeness is a 100% natural, biodegradable tissue implant, consisting of a gel derived from agarose. Read More

Lasers Surg Med 2020 Apr 29. Epub 2020 Apr 29.

CNP Skin Clinic, Cheonan, 147, Gosokcheol-daero, Asan, Chungcheongnam-do, 31470, Republic of Korea.

Background And Objectives: Combined sequential treatments with multiple modalities such as lasers and soft-tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond-domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond-domain fractional laser treatment over hyaluronic acid fillers (HAFs). Read More

Dermatol Ther 2020 Apr 19:e13424. Epub 2020 Apr 19.

Department of Plastic Surgery, Fortis Hospital, Mohali, Punjab, India.

As most Asian women desire to have an "inverted triangle" appearance for face, there is an increasing trend to give a large volume bolus (LVB) injection in the submental region of the chin for its lengthening. Hyaluronic acid (HA) dermal fillers are very popular for facial contouring and reshaping, including the chin area. Filler injection in the submental area has been a popular method to lengthen the chin. Read More

J Cosmet Dermatol 2020 Jun 12;19(6):1301-1306. Epub 2020 Apr 12.

Dermatology and Venereology, Nazilli State Hospital, Aydın, Turkey.

Background: A chin that is of right size, shape, and contour plays a crucial role in overall facial balance and esthetically harmonious appearance. Dermal fillers have been widely used for correcting mild to moderate chin retrusion and resorption.

Aims: The aim of this study was to share our preferential technique for chin augmentation and to evaluate our results in 50 patients. Read More

Ann Dermatol Venereol 2020 Apr 7. Epub 2020 Apr 7.

Cabinet de dermatologie, 34, avenue d'Allemagne, 80000 Amiens, France.

Background: Collagen stimulators such as Ellansé® are soft tissue fillers able to induce nucleogenesis. We describe a case of eruptive foreign body granulomas following injection of Ellansé® that were successfully treated using methotrexate.

Case Report: A 47-year-old woman received injections of Ellansé® for the wrinkled aspect of her cheeks. Read More

J Drugs Dermatol 2020 Apr;19(4):405-411

Background/Objectives: Treatment options for the correction of age-related changes in skin include the use of energy-based devices and dermal fillers. In this study, we evaluate the clinical efficacy and tolerability of microfocused ultrasound with visualization (MFU-V) and injectable calcium hydroxylapatite (CaHA) filler diluted with normal saline, for the correction of age-related changes and to assess patients' satisfaction with this combination therapy. Methods: This was a randomized, split-face, comparative clinical study and immunohistochemical analysis in 20 subjects with indications for lower face, neck and décolleté lifting. Read More

Cureus 2020 Feb 29;12(2):e7141. Epub 2020 Feb 29.

Surgery, School of Medicine, National and Kapodistrian University of Athens, Athens, GRC.

The supratrochlear artery represents a terminal branch of the ophthalmic artery. Cosmetic interventions may traumatize it, resulting in a circulation in the lesion in glabellar region and in the medial aspect of the forehead. This review article aims to synopsise the existing knowledge of the anatomy of the supratrochlear artery in close correlation with minimally invasive cosmetic procedures in the facial area such as soft-tissue filler injections. Read More

J Dermatolog Treat 2020 Apr 6:1-7. Epub 2020 Apr 6.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Filler injection has become an extremely popular method for facial skin rejuvenation, including the periorbital area. In the recent years, new polynucleotide (PN)-containing filler products have been used for esthetic purposes. We aimed to investigate the efficacy and safety of PN filler injection in the periorbital area. Read More

J Cosmet Dermatol 2020 Jun 3;19(6):1311-1315. Epub 2020 Apr 3.

Dermatology and Venereology, Nazilli State Hospital, Aydın, Turkey.

Background: Hyaluronic acid (HA) fillers have been widely used for reversing the signs of the aging face. Injectable fillers are particularly effective in treating vertical glabellar wrinkles.

Aims: The aim of this study was to share our own safe glabella filling technique and to evaluate our results in 50 patients with facial rejuvenation. Read More

Aesthetic Plast Surg 2020 Mar 23. Epub 2020 Mar 23.

Department of Plastic Surgery of Peking Union Medical College Hospital Of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: Botulinum toxin injection, micro-needling injection, and filler injection are the most widely used non-surgical facial cosmetic treatments. Hypersensitivity reactions associated with injections have not received sufficient attention due to their low incidence rates. The authors tried to summarize the characteristics of the hypersensitivity caused by cosmetic injections and helped to improve the diagnosis and treatment. Read More

J Stomatol Oral Maxillofac Surg 2020 Mar 20. Epub 2020 Mar 20.

Department of otolaryngology and head and neck surgery, Changeux Building, Simone-Veil hospital, 14, rue de Saint-Prix, 95600 Eaubonne, France.

Background: Surgical revision rate of rhinoplasty is from 5% to 15% in literature.

Objective Of Review: In the context of post-rhinoplasty deformities, we aim to investigate the modalities of using injectables, their impacts on revision rate of rhinoplasty as well as their influences on the surgical strategy.

Type Of Review: We realized an international literature review to collect informations on main studies reporting series of exclusive secondary medical rhinoplasties or mixed primary/secondary medical rhinoplasties, as well as per-operative injection. Read More

Australas J Dermatol 2020 Mar 22. Epub 2020 Mar 22.

Skin Institute, Remuera, Auckland, New Zealand.

Facial aesthetic treatment with injectable neuromodulators and hyaluronic acid fillers is well established, with favourable safety profiles and consistent outcomes. As with any medical treatment, adverse events and complications may occur. Adverse events associated with these products are typically transient and mild to moderate in severity. Read More

Facial Plast Surg 2020 Feb 19;36(1):129-130. Epub 2020 Mar 19.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Weill Cornell Medicine, New York, New York.

J Cosmet Dermatol 2020 Mar 17. Epub 2020 Mar 17.

Falck Clinic, Aesthetic Medicine Centre, Amsterdam, The Netherlands.

Background: Inadvertent intra-arterial injection of dermal fillers including calcium hydroxylapatite (CaHA) can result in serious adverse events including soft tissue necrosis, permanent scarring, visual impairment, and blindness. When intra-arterial injection occurs, immediate action is required for optimal outcomes, but the infrequency of this event means that many physicians may never have experienced this scenario. The aim of this document is to provide evidence-based and expert opinion recommendations for the recognition and management of vascular compromise following inadvertent injection of CaHA. Read More

Prog Retin Eye Res 2020 Mar 10:100848. Epub 2020 Mar 10.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Iatrogenic ophthalmic artery occlusion (IOAO) is a rare but devastating ophthalmic disease that may cause sudden and permanent visual loss. Understanding the possible etiologic modalities and pathogenic mechanisms of IOAO may prevent its occurrence. There are numerous medical etiologies of IOAO, including cosmetic facial filler injection, intravascular procedures, intravitreal gas or drug injection, retrobulbar anesthesia, intraarterial chemotherapy in retinoblastoma. Read More

Aesthet Surg J 2020 Mar 11. Epub 2020 Mar 11.

Background: Autologous fat is known for a reliable and natural safety profile, but complications do occur - even serious vascular adverse events.

Objectives: To examine duplex-ultrasound (DUS) imaging for the harvesting and subsequent facial implantation of autologous fat tissue.

Methods: All patients underwent lipofilling treatment of the temporal fosse of the face. Read More

JPRAS Open 2019 Jun 17;20:94-100. Epub 2019 Apr 17.

GLAD Plastic Surgery Clinic, 31 Dongsung-ro 5-gil, 3rd floor, Jung-gu, Daegu 41941, Republic of Korea.

Filler rhinoplasty is susceptible to spreading because of the way the nose protrudes away from the face. Often, the well-defined appearance immediately after the procedure is poorly maintained, and the nasion area develops a bulbous appearance. Therefore, I developed a "dual plane technique" to prevent spreading and to maintain the desired shape of the filler rhinoplasty. Read More

Dent Clin North Am 2020 04 17;64(2):325-339. Epub 2020 Jan 17.

Department of Oral & Maxillofacial Surgery, Woodhull Medical Center, 760 Broadway, Brooklyn, NY 11206, USA.

For the general dentist, the use of BTA and dermal fillers confers the ability to exert control over the soft tissues surrounding the mouth to better create a harmonious smile. The injection of BTA and fillers into the facial musculature and dermis requires a level of finesse to achieve the desired outcomes. A sound understanding of the mechanisms of action and the ability to manage potential complications are also necessary, because the dentist administering BTA and dermal fillers must be competent to the same level as other providers who have traditionally been the gatekeepers of such agents. Read More

Aesthetic Plast Surg 2020 Feb 10. Epub 2020 Feb 10.

Department of Otolaryngology, Tulane University Medical Center, 1430 Tulane Ave, #8659, New Orleans, LA, 70112, USA.

Background: Medical tourism for cosmetic surgery has become increasingly popular in recent years. The existing literature has identified poor outcomes associated with general cosmetic tourism; however, the complications associated with cosmetic tourism for facial rejuvenation remain poorly understood. The aims of this study are to delineate the risk profile associated with medical tourism for facial rejuvenation. Read More

Clin Interv Aging 2020 13;15:39-45. Epub 2020 Jan 13.

Department of Geriatric Medicine and Gerontology, Poznan University of Medical Sciences, Poznan, Poland.

Background: Skin ageing is a physiological process, progressive and irreversible. Hyaluronic acid injection treatments are used to correct the signs of skin ageing.

Material And Methods: Hyaluronic acid was implanted in the area of the cheek and the forehead aesthetic units in 57 women, aged 35-55 years. Read More

Plast Reconstr Surg 2020 Feb;145(2):295e-305e

Philadelphia, Pa.; Toronto, Woodbridge, and Yorkville, Ontario, Canada; and Fort Worth, Texas From the Division of Plastic Surgery, University of Pennsylvania; the Division of Dermatology, University of Toronto; private practice; the Division of Dermatology, Women's College Hospital; Cosmetic Dermatology; and Galderma Laboratories, L.P.

Background: Objective dynamic assessments are central to the evaluation of facial rejuvenation treatments. This study used three-dimensional digital stereophotogrammetry to generate a quantitative dynamic assessment of facial strain and hyaluronic acid filler efficacy.

Methods: Thirty women (aged 41 to 65 years) with moderate to severe bilateral nasolabial folds and marionette lines received Restylane Refyne, Restylane Defyne, or both, and were compared to a "younger" untreated group (n = 20; aged 25 to 35 years). Read More

Dermatol Surg 2020 Jan 17. Epub 2020 Jan 17.

Both authors are affiliated with Expert2expert, Paris, France.

Background: To minimize complications with injectable fillers, aesthetic practitioners need a detailed knowledge of facial anatomy.

Objective: To describe a novel approach ("subtractive anatomy") to identify locations where lip eversion using filler injections would be well tolerated and to evaluate the "French kiss technique" (FKT) to enhance the length of the lips using a low cohesivity hyaluronic acid filler.

Materials And Methods: Twenty hemifaces were dissected from 10 nonembalmed, nonfrozen Caucasian cadavers to assess subtractive anatomy. Read More

J Cosmet Dermatol 2020 Feb 10;19(2):312-320. Epub 2020 Jan 10.

Division of Anatomy, Department of Medical Education, Albany Medical College, Albany, NY, USA.

Background: Soft tissue filler product distribution and tissue integration have been shown to depend on myriad factors including the injector type, injector size, and injection angle.

Aim: This study aims to investigate the magnitude of product spread across fascial soft tissue layers in relation to product viscoelastic properties.

Patients/methods: A total of 168 injection procedures were conducted in two female Caucasian body donors with a mean age of 80 years (range: 79-81) and a mean body mass index of 23. Read More

Arch Dermatol Res 2020 Jan 2. Epub 2020 Jan 2.

Dermatology Department, Kasr Al Ainy Faculty of Medicine Cairo University, Cairo, Egypt.

Nasolabial folds are caused by loss of deep fat and subsequent loss of muscle contour in the midface, leading to sagging which forms cosmetic issues in some cases when they are otherwise overly pronounced. Various treatment procedures have been developed to reduce their appearance. The objective of this study is to compare the efficacy of hyaluronic acid (HA) cheek fillers injection and thread lifting in improving the nasolabail folds. Read More

J Cosmet Dermatol 2020 Mar 30;19(3):570-573. Epub 2019 Dec 30.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Background: Cosmetic surgery and esthetic procedures have become a billion dollar industry owing to the ever-growing demand of the population to stay young. The injectable treatments including fillers and botulinum toxin have become highly popular because of their quick, predictable and lasting results in the management of facial wrinkles and rejuvenation. Although these treatment modalities are relatively safe, they are associated with certain side effects. Read More

J Cosmet Dermatol 2019 Dec 31. Epub 2019 Dec 31.

Cosmetic Laser Dermatology, La Jolla, CA, USA.

Background: A well-defined jawline is a critical component in the perception of facial attractiveness in both men and women. Dermal fillers offer a nonsurgical, temporary method of correcting mild-to-moderate mandibular bone resorption.

Aims: The authors discuss pertinent aspects of anatomy, pathophysiology of aging, patient evaluation, gender considerations, injection technique, and complications in jawline augmentation using injectable fillers. Read More

Plast Reconstr Surg 2020 01;145(1):51e-57e

Bangkok, Thailand; and Birmingham, United Kingdom From the Department of Anatomy, Faculty of Medicine, and the Chula Soft Cadaver Surgical Training Center, Chulalongkorn University and King Chulalongkorn Memorial Hospital; the Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University; and the Department of Anatomy and Human Biology, University of Birmingham.

Background: Facial proportions can be improved by means of chin augmentation in patients with a receding chin. The ascending mental artery is the main arterial supply to the top of the chin, and arterial occlusion of this artery can result in soft-tissue infarction. This study aims to measure the topographic anatomy of the ascending mental artery at the chin injection area, using a three-dimensional camera. Read More

Plast Reconstr Surg 2020 01;145(1):42e-50e

Beijing, People's Republic of China From the Departments of Burn and Plastic Surgery, Radiology, and Ophthalmology, The Fourth Medical Center of Chinese PLA General Hospital.

Background: With an increase in recent years in the number of people receiving cosmetic facial injection treatments of hyaluronic acid, the incidence of hyaluronic acid embolism has also increased commensurately. Hyaluronic acid embolism leads to serious complications, including blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. However, there is a lack of robust clinical evidence regarding the benefits of treatment for hyaluronic acid embolism by intraarterial thrombolysis therapy. Read More

BMC Ophthalmol 2019 Dec 16;19(1):254. Epub 2019 Dec 16.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, Republic of Korea.

Background: To investigate the surgical outcomes of strabismus related to iatrogenic occlusion of the ophthalmic artery and its branches from cosmetic facial filler injection.

Methods: A retrospective study was performed on 6 patients who underwent strabismus surgery among 23 patients who had suffered occlusion of the ophthalmic artery and its branches after cosmetic facial filler injection. Initial, preoperative and final ocular motility examinations, the type of surgery and surgical outcomes were evaluated. Read More

J Cosmet Dermatol 2020 Feb 15;19(2):303-311. Epub 2019 Dec 15.

Division of Anatomy, Department of Medical Education, Albany Medical College, Albany, NY, USA.

Background: Recent advances in facial anatomy have increased our understanding of facial aging and where to best position facial soft tissue fillers.

Aim: Aim of this study was to investigate a novel injection protocol which makes use of concepts like the line of ligaments or the surface - volume coefficient.

Materials And Methods: A total of 306 Caucasian patients (270 females, mean age 45. Read More

Aesthetic Plast Surg 2019 Dec 10. Epub 2019 Dec 10.

Maxillofacial Surgery Division, University of Verona, Verona, Italy.

Background: With the global increase in the use of injectable fillers, more cases with serious adverse events such as skin ischemia and vision loss are being reported. This article aims to review the role of HA fillers, as a subgroup separate from fat graft and non-HA fillers, in causing vision loss and to elucidate various features and outcomes of post-HA filler vision loss.

Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were used to report this review. Read More

Clin Cosmet Investig Dermatol 2019 26;12:857-864. Epub 2019 Nov 26.

Croma-Pharma GmbH, Leobendorf 2100, Austria.

Purpose: Nasolabial folds (NLFs) are one of the most noticeable signs of facial aging. NLFs negatively affect self-confidence and social acceptance often leading to a person's desire to improve their appearance using dermal fillers. The hyaluronic acid injectable gel implant Princess FILLER Lidocaine (PFL) is a minimally invasive easy to administer the product. Read More

J Craniofac Surg 2020 Jan/Feb;31(1):271-273

Department of Ophthalmology, Bundang CHA Hospital, CHA University, College of Medicine, Seongnam, Republic of Korea.

Purpose: Hyaluronic acid gel (HAG) fillers provide a versatile and safe correction method for a sunken superior sulcus (SS) resulting from soft tissue volume loss occurring with aging, previous surgery, or enophthalmos related to trauma or phthisis bulbi. The purpose of this study was to report the long-term clinical outcomes of filler injection for soft-tissue augmentation in patients with a deep SS.

Design: Retrospective, interventional case series METHODS:: The medical records of 27 patients (32 eyes) with deep superior sulci were reviewed. Read More

Plast Surg Nurs 2019 Oct/Dec;39(4):119-124

Rachel Varga, BScN, RN, is an aesthetic nurse, practicing in Hillside, Victoria, British Columbia, Canada. She is a clinical instructor, international speaker, trainer for Alladina Medical Ltd, writer, and founder of Rachel Varga Inc, specializing in anti-aging education for both the client and the clinician.

The periorbital area is the first area of the face to show signs of aging. To provide safe and natural looking rejuvenation of the delicate eyelids, and supporting structures, an advanced understanding of anatomy, ideal facial proportions, and the most effective methods for rejuvenation is discussed. Periocular rejuvenation is particularly challenging due to the intricate and delicate anatomy of the periocular area. Read More

J Cosmet Dermatol 2019 Nov 26. Epub 2019 Nov 26.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Background: There have been few studies using hyaluronic acid fillers to restore mid-face volume deficit especially in Asians.

Aims: This study compared the efficacy and safety of two highly cohesive hyaluronic acid fillers, Neuramis® Volume Lidocaine and Juvederm® Voluma® with Lidocaine (VYC-20L), for temporary restoration of mid-face volume in Asians.

Patients/methods: A total of 88 subjects with moderate to severe age-related mid-face volume deficit on the Mid-Face Volume Deficit Scale (MFVDS) received Neuramis® Volume Lidocaine on one side and VYC-20L on the other side of the face. Read More

Plast Reconstr Surg 2019 12;144(6):1002e-1009e

München, Germany; Cartago, Costa Rica; Gainesville, Fla.; and Linz, Austria From the Departments of Plastic Surgery and Hand Surgery and Orthopedics and Sportsorthopaedics, Klinikum rechts der Isar, Technische Universität München; the Biotechnology Research Center, Costa Rica Institute of Technology; the College of Pharmacy, University of Florida; and the Section for Plastic and Reconstructive Surgery, Kepler University Hospital.

Background: Beside botulinum-toxin injections and hyaluronic acid fillers, thread lifts have established themselves as the third column of minimally invasive facial rejuvenation. Most commonly, barbed threads for this approach are made out of polydioxanone, a material known for decades from application in resorbable sutures. The clinical efficacy and the putative material safety of polydioxanone have fueled the popularity of thread lifts. Read More

J Oral Maxillofac Surg 2020 Mar 19;78(3):440-445. Epub 2019 Oct 19.

Director, Beau Visage Med Spa, Cheshire, CT; Private Practice, Greater Waterbury OMS, Cheshire, CT; and Associate Clinical Professor, University of Connecticut, Farmington, CT. Electronic address:

The use of facial fillers for soft tissue augmentation is becoming a mainstream treatment modality for patients. Owing to the relative ease of administration, as well as the lucrative nature of such procedures, the number of providers offering facial fillers has been expanding. Although many adverse effects of facial fillers are minor and localized to the site of injection, 1 potential serious, albeit uncommon, adverse effect of facial filler treatment is avascular necrosis. Read More

J Cosmet Dermatol 2020 Apr 11;19(4):772-781. Epub 2019 Nov 11.

Department of Plastic and Reconstructive Surgery, Hanyang University Seoul Hospital, Seoul, South Korea.

Background: Soft tissue filler is commonly used for facial contouring. However, incorrect use can lead to severe ocular complications. Even though filler injections are quite different from fat grafts, they are considered similar procedures. Read More

J Cosmet Dermatol 2019 Nov 6. Epub 2019 Nov 6.

Department of Dermatology, Klinikum Darmstadt, Darmstadt, Germany.

Background: In addition to having a younger and more attractive appearance after facial aesthetic treatment, patients desire natural-looking and long-lasting results.

Objective: To evaluate perceived naturalness of dynamic facial expressions after treatment with hyaluronic acid fillers in nasolabial folds (NLFs) and lower face wrinkles and folds.

Methods: Subjects requiring treatment of moderate-to-severe NLFs and at least one other lower face indication were treated with hyaluronic acid fillers. Read More

Dermatol Surg 2019 Oct 31. Epub 2019 Oct 31.

Division of Oculoplastics, Stein Eye Institute, University of California, Los Angeles, Los Angeles, California.

Background: Injectable fillers have become an integral part of facial rejuvenation, but vascular occlusion is a dreaded complication of such injections.

Objective: To determine the force required by the fingertip onto the plunger of the syringe to cause retrograde migration.

Methods: In this cadaver study, twelve 2-cm arterial segments and 4 fillers were tested. Read More

Saudi J Ophthalmol 2019 Jul-Sep;33(3):251-254. Epub 2019 Jul 25.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: To report the long-term follow-up results after surgical excision of migrated Bio-Alcamid fillers to the Periorbita area.

Methods: A retrospective case series of all patients who underwent surgical removal of migrated Bio-Alcamid fillers to the Periorbita area with minimal follow-up of 1 year from January 2009 to January 2018 was done.

Results: 16 female patients (24-52 y) presented with an upper or lower eyelid swelling 3-7 years following a filler injection in the nasal bridge, temporal or malar area. Read More

J Cosmet Dermatol 2019 Nov 4. Epub 2019 Nov 4.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Background: No data on the clinical results and safety profiles of the polycaprolactone (PCL) -based dermal filler for crow's feet correction have been published.

Aims: This study was designed to compare the efficacy and safety of a novel PCL-based dermal filler, DLMR01, with that of RJR, a purified polynucleotide dermal filler.

Patients/methods: A total of 30 subjects with symmetric crow's feet of 2-4 points on the Crow's Feet Grading Scale (CFGS) were enrolled in this randomized, patient/evaluator-blinded, split-face study. Read More

J Eur Acad Dermatol Venereol 2020 Apr 28;34(4):817-820. Epub 2019 Nov 28.

Department of Dermatology, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-André, Bordeaux, France.

Background: Granulomatous foreign body reactions (GFBR) have been reported after injection with almost every soft tissue fillers, more commonly with non-biodegradable ones. Such granulomatosis is rare but can cause significant discomfort owing to their aesthetic and functional repercussions.

Objective: To determine whether immunomodulation with low doses of methotrexate is effective in the treatment of GFBR to filler material. Read More