Search Our Scientific Publications & Authors

J Cosmet Dermatol 2022 Jun 29. Epub 2022 Jun 29.

Head and Neck surgeon, Mediti Clinic, 90 Bd Francis Meilland, 06160, Antibes, France.

Background: Hyaluronic acid - based fillers have an immediate volumizing effect for the treatment of dermal contour deformities and to smooth dermal depressions formed by the loss of volume. A previous study on 2016-2018 has shown the efficacy and safety of the HA-based filler ART FILLER® Volume on the midface only, but not in a comparative manner.

Methods: In this context, an 18-months prospective randomized single-blind study of the non-inferiority of ART FILLER® Volume versus the reference product Juvéderm Voluma® was performed on the midface, temple and jawline and non-comparative study on the chin. Read More

Aesthet Surg J 2022 Jun 28. Epub 2022 Jun 28.

Division of Plastic Surgery, Department of Surger, University of Pennsylvania, Philadelphia, PA, USA.

Background: Over the last two decades, both invasive and minimally-invasive aesthetic procedures have proliferated. Aesthetic surgeons often recommend injectable treatments after cosmetic facial surgery for multiple reasons. Yet, literature is lacking on how cosmetic surgery affects post-operative facial injectable use. Read More

Clin Cosmet Investig Dermatol 2022 21;15:997-1019. Epub 2022 Jun 21.

Behavior, Paris, France.

The number of aesthetic procedures performed worldwide continues to grow together with an increase in the population seeking the restoration or preservation of a youthful appearance. Requests for non-surgical body rejuvenation are increasing. Patients are looking for safe and effective minimally invasive aesthetic procedures. Read More

J Craniofac Surg 2022 Jun 27. Epub 2022 Jun 27.

Paulista University (UNIP), Sao Paulo, Brazil.

Abstract: Surgical treatment of head and neck cancer causes severe tissue loss, therefore, deformities and psychosocial consequences. In cases involving orbit exenteration, satisfactory reconstruction can only be achieved with prosthetic replacement, despite successful reconstructive plastic surgery. Extraoral implants, 3D scanning, and prototyping technologies have contributed to increase satisfactory aesthetic results of oculofacial prosthesis. Read More

JPRAS Open 2022 Sep 24;33:37-41. Epub 2022 May 24.

University of Colorado School of Medicine, Department of Otolaryngology, 12631 E 17th Ave, Aurora, CO 80045, United States.

Hyaluronic acid-based filler is the most popular injectable augmentation preparation due to its efficacy and safety compared to other injection fillers. The complication of infected filler is known, but it is unknown exactly how long filler persists prior to reabsorption. A case was presented of filler-exacerbated facial cellulitis that occurred 2. Read More

J Cosmet Dermatol 2022 Jun 19. Epub 2022 Jun 19.

Dermatologist, 2 Rue de Lisbonne, 75008, Paris, France.

Background: Age-related changes of facial soft tissue cause clinical signs of facial ageing such as lip atrophy, marionette lines and an accentuated nasolabial fold. These changes can be modified using dermal fillers.

Aims: To evaluate efficacy, longevity and safety of a cross-linked hyaluronic acid- based filler with Tri-Hyal technology in the treatment of lips, nasolabial folds and marionette lines. Read More

Clin Anat 2022 Jun 4. Epub 2022 Jun 4.

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, South Korea.

Hyaluronic acid filler injection is a minimally invasive procedure for facial rejuvenation that involves injecting filling materials to correct the volume or augment specific areas in the face. Deep nasolabial folds are a common concern in aging people. The simplest way to correct a deep nasolabial fold to rejuvenate the face is to inject Ristow's space with hyaluronic acid fillers. Read More

Biomed Res Int 2022 26;2022:3790546. Epub 2022 May 26.

Department of Anatomy, Yonsei University Medical College, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.

A hollow temple may give rise to a false impression of early facial aging. This is corrected with dermal fillers that are injected into the hollow temple area to produce a smoother facial contour. However, various complications of this procedure have been reported, with the most common being the inadvertent injection of the filler material into the superficial temporal artery (STA). Read More

Dermatol Surg 2022 Jun 22;48(6):695-696. Epub 2022 Mar 22.

Department of Dermatology, University of California, Irvine, Irvine, California.

Cureus 2022 Apr 25;14(4):e24461. Epub 2022 Apr 25.

Dermatology, Academy of Aesthetic Medicine, Sheffield, GBR.

Hyaluronic acid dermal fillers are a very popular choice for patients wanting to undergo non-invasive facial rejuvenation. Its prevalence is predicted to continue to rise. We report a case of delayed angioedema and associated urticaria to hyaluronic acid dermal fillers post COVID-19 infection. Read More

Aesthetic Plast Surg 2022 May 17. Epub 2022 May 17.

ENT Surgeon, Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, CNRS, IUSTI, APHM, Aix-Marseille Univ, 147 Bd Baille, 13005, Marseille, France.

Background: Nasal valve disorders frequently give rise to nasal obstruction. Dermal fillers could be used in the internal valve area to generate valve widening. The goal of this study was to report our "liquid spreader" procedure consisting in the injection of hyaluronic acid (HA) at the internal nasal valve in patients complaining of nasal obstruction. Read More

Aesthetic Plast Surg 2022 May 13. Epub 2022 May 13.

Department of Plastic Surgery, AZ Zeno Hospital, Kalvekeetdijk 260, 8301, Knokke-Heist, Belgium.

From this article of Diaspro and colleagues, we can safely conclude that it proves that HA fillers are an effective treatment of tear troughs. A full analysis of the face in general, and the peri-orbital area in particular, is essential to select the right candidates for this treatment. A thorough knowledge of the anatomy is essential to do this selection and to avoid possibly serious complications. Read More

J Drugs Dermatol 2022 May;21(5):481-487

Background: Soft tissue augmentation with calcium hydroxylapatite (CaHA) is a versatile technique for line filling, skin tightening, lifting, contouring, and volumizing. The present study was designed to confirm safety and effectiveness of the product with lidocaine (CaHA (+)) in a holistic treatment of nasolabial folds (NLFs), marionette lines, and/or cheeks.

Methods: A total of 207 subjects with moderate to severe facial volume deficit were treated with CaHA(+) in this open-label study. Read More

Plast Reconstr Surg 2022 07 6;150(1):87e-91e. Epub 2022 May 6.

From the Department of Dermatology, Chung-Ang University College of Medicine; and the Yemiwon Dermatologic Clinic.

Summary: Hyaluronic acid fillers are widely used for the augmentation of facial soft tissues. Hyaluronic acid fillers can be monophasic or biphasic and have different characteristics, especially regarding volumetric effects and maintenance potential. However, there is paucity of long-term quantitative and objective data on clinical outcomes following hyaluronic acid injection. Read More

Facial Plast Surg Clin North Am 2022 May;30(2):233-237

Department of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, St Louis, MO, USA.

The demand and use of injectable fillers are increasing and performed by practitioners at different levels. They are frequently used to rejuvenate and volumize the face, but there are well-known complications that can occur with intraluminal injection or compression of the facial vessels. The knowledge of the vascular anatomy of the face, particularly the predictable depth, can prevent these devastating complications. Read More

Facial Plast Surg Clin North Am 2022 May;30(2):183-191

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Mayo Clinic, Stabile Building 9-38, 200 First Street, Rochester, MN, 55905, USA. Electronic address:

Nasal enhancement is one of the most challenging and intriguing of aesthetic procedures. Although the nose is the most central and prominent facial feature, it should not be dominant while maintaining both a harmonious relationship with the face and its own intrinsic beauty. In this article, the first author shares his experience on how to specifically apply intradermal soft-tissue fillers (for particular indications) in nasal enhancement and incorporates patient assessment, anatomy of the nose, and injection techniques to provide guidance. Read More

Facial Plast Surg Clin North Am 2022 May;30(2):135-141

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address:

Nonsurgical rhinoplasty procedures using soft tissue fillers have gained popularity. With the increasing frequency of such procedures, the incidence of intra-arterial injection of soft tissue filler material and subsequent ischemia has also risen. This article analyzes the topographic anatomy of the dorsal nasal artery in the nasal soft tissue to potentially enhance patient safety in nonsurgical rhinoplasty procedures. Read More

J Cosmet Dermatol 2022 Jun 13;21(6):2379-2386. Epub 2022 May 13.

Pacific Derm, The Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Data suggest that hyaluronic acid (HA) fillers using VYC technology have a higher incidence of delayed-onset nodule development at facial injection sites than earlier HA products.

Objective: To assess the incidence of delayed-onset nodules with VYC products based on a single experienced injector.

Methods And Materials: Patients with delayed-onset nodules after injections with VYC-20L, VYC-17. Read More

Clin Cosmet Investig Dermatol 2022 15;15:691-701. Epub 2022 Apr 15.

Department of Dermatology, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Northwest University, Xi'an, 710069, People's Republic of China.

Background: Hyaluronic acid (HA)-based fillers are applied to treat facial wrinkles and volume loss. Many efforts have been made to improve properties of HA to prolong the duration in aesthetic indications. A new cross-linking technique called "Tri-Hyal", could make HAs to achieve desired rheological characteristics. Read More

Aesthet Surg J 2022 May;42(6):656-659

J Drugs Dermatol 2022 Apr;21(4):387-392

Restylane® Lidocaine is one of the most widely used hyaluronic acid (HA) fillers to replace lost or displaced volume during tear trough correction. Patient goals for tear trough correction include looking less tired or removing dark circles and this may be achieved by administering HA filler into the infraorbital region to correct the lower eyelid relative to the volume deficit, thereby smoothing the transition from the lower eyelid to the cheek. To achieve patient satisfaction and consistent results with Restylane, optimal application is essential; however, clinical guidance based on experience is limited. Read More

J Drugs Dermatol 2022 Apr;21(4):354-362

The popularity of minimally invasive injectable aesthetic treatments has grown exponentially with over thirteen million neurotoxin and dermal filler injections being performed in 2014. While aesthetic results can be dramatic and convalescence minimal, significant complications including vascular compromise, neuropraxia, and blindness have been reported. Thorough knowledge of the complex anatomy in this area and the use of anatomic landmarks can help the physician obtain improved aesthetic results by deploying fillers in the appropriate anatomic plane and avoiding inadvertent injury to important neurovascular structures in this area. Read More

Skeletal Radiol 2022 Apr 2. Epub 2022 Apr 2.

Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea.

Recently, many attempts have been made to use injectable materials in the subcutaneous fat layer anywhere in the body, including the breast and face, for cosmetic purposes. A 56-year-old woman presented with multiple palpable lumps without tenderness or skin color changes on the anterior and lateral chest and the abdominal walls. Magnetic resonance imaging showed fluid-like collections without surrounding soft tissue inflammatory changes in the chest wall, abdominal wall, and deeper within the abdomen. Read More

J Cosmet Dermatol 2022 Jun 9;21(6):2387-2397. Epub 2022 May 9.

Beijing Hospital, Ministry of Health, Beijing, China.

Background: The therapeutic effects of hyaluronic acid dermal fillers to correct facial wrinkles and folds usually last up to 6-12 months. Few studies have evaluated their long-term safety.

Aims: To evaluate the long-term safety and biodegradability of two hyaluronic acid dermal fillers (YVOIRE classic s and YVOIRE volume s) for the correction of nasolabial folds (NLFs) in two prospective, observational studies. Read More

J Clin Aesthet Dermatol 2022 Mar;15(3):38-43

Drs. Aksenenko, Gerasimenko, and Evstigneeva are with the Federal State Budgetary Educational Institution of Further Professional Education of the Ministry of Healthcare of the Russian Federation in Moscow, Russia.

Background: Fillers based on calcium hydroxyapatite (CaHA) have become popular for the correction of involutive skin changes. However, if the filler injection technique is violated, undesirable events can occur in the skin, the treatment of which is complicated by the lack of a specific antidote to CaHA.

Objective: In this study, we aimed to evaluate the effectiveness of a combined method that includes a course of ultraphonophoresis of collagenase and diadynamophoresis of sodium thiosulfate (NaSO) for the treatment of complications developed after contour correction with CaHA-based fillers. Read More

J Clin Aesthet Dermatol 2022 Mar;15(3):53-56

All authors are with the Sackler Faculty of Medicine at Tel Aviv University in Tel Aviv, Israel.

Background: Postacne facial scars are often associated with significant patient distress. Energy-based devices, including non-ablative lasers, are commonly used for the treatment of postacne scarring. There is relatively limited data regarding the combination of non-ablative lasers with hyaluronic acid injections for postacne scarring. Read More

J Clin Aesthet Dermatol 2022 Feb;15(2):40-43

All authors are with Hospital Moriah in São Paulo, Brazil.

Facial injections with hyaluronic acid (HA) dermal fillers have become increasingly common. Hyaluronic acid is currently the most frequently used dermal filler. When compared to collagen for the treatment of nasolabial folds, HA not only produces similar cosmetic results with smaller doses but also lasts longer. Read More

J Cosmet Dermatol 2022 Mar 17. Epub 2022 Mar 17.

Berkowits Hair and Skin Clinic, New Delhi, India.

Background: Non-surgical, minimally invasive techniques are an effective way to bring a facelift with long lasting results; and minimal downtime and side effects. Due to an increased awareness and growing social acceptability, a large number of patients have been seeking these treatments to maintain a youthful appearance.

Objective: To assess the efficacy of combined use of PDO threads and hyaluronic acid fillers for non-surgical facelift in a male patient. Read More

J Clin Aesthet Dermatol 2021 Dec;14(12 Suppl 1):S15-S17

Dr. Ostezan is a board-certified dermatologist who practices aesthetic dermatology in Reno, Nevada.

Delayed-onset nodules, a potential complication of injectable hyaluronic acid (HA) fillers, can be distressing to both patient and clinician. Current treatment options, including oral corticosteroids and antibiotics, have potential side effects and may be ineffective or contraindicated in some patients. Hyaluronidase is an enzyme used to degrade HA fillers. Read More

J Cosmet Dermatol 2022 Mar 13. Epub 2022 Mar 13.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Restylane Defyne (HA , with lidocaine) has been shown to be effective and safe for facial augmentation including nasolabial folds (NLFs) in Caucasians. Incorporating lidocaine in injectable fillers has become a common practice that improves the patient's experience.

Objectives: To evaluate efficacy and safety of HA compared to Restylane (HA , the gold standard HA filler) for correction of NLFs in a Chinese population. Read More