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Facial Plast Surg 2021 May 11. Epub 2021 May 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim, Germany.

Management of the skin-soft tissue envelope (SSTE) in rhinoplasty is challenging and critical for the overall outcome. The preoperative identification of patients with thick or thin skin and with preexisting skin conditions may contribute significantly to the postsurgical result. Most publications and textbooks focus on the management of the osseocartilaginous framework, but the SSTE management is often not addressed in detail. Read More

J Phys Condens Matter 2021 May 11. Epub 2021 May 11.

National Institute of Science Education and Research School of Physics, Khurda, Jatani, 752050, INDIA.

Scattering of spin-up and spin-down electrons while passing through a ferromagnetic domain wall leads to an additional resistance for transport current, usually observed prominently in constricted magnetic structures. In this report we use the resistance of the domain wall as a probe to find an indirect signatures of the theoretically predicted spin-singlet supercurrent to spin-triplet supercurrent conversion effect of ferromagnetic domain walls. Here we examine the domain wall induced resistance in Ni stripe in a bilayer Ni/Nb geometry in the normal state and in the superconducting state of Nb. Read More

Biomaterials 2021 Apr 29;274:120855. Epub 2021 Apr 29.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:

Drug-loaded hydrogels can improve blood supply and inhibit extracellular matrix degradation after myocardial infarction. However, due to the continual dynamic motion of cardiac tissue, the hydrogel structure cannot be reconstructed in time, causing accelerated degradation and drug burst release. Here, a novel, superior, self-healing elastin-mimic peptide hydrogel (EMH) was fabricated for the local delivery of salvianolic acid B (SaB). Read More

Biomaterials 2021 Apr 29;274:120862. Epub 2021 Apr 29.

Department of Surgery, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address:

Smoke inhalation injury is associated with significant mortality and current therapies remain supportive. The purpose of our study was to identify proteins upregulated in the lung after smoke inhalation injury and develop peptide amphiphile nanofibers that target these proteins. We hypothesize that nanofibers targeted to angiotensin-converting enzyme or receptor for advanced glycation end products will localize to smoke-injured lungs. Read More

Neurosci Lett 2021 May 8:135949. Epub 2021 May 8.

Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

It has been suggested that gut microbiota dysbiosis can lead to Alzheimer's disease (AD), inducing the production of many AD-related pre-inflammatory cytokines. On the other hand, daily probiotic administration and regular exercise training are assumed to improve clinical AD-related symptoms. To take this line of research further, this study was aimed at investigating the impact of moderate-intensity interval training (MIIT) with a combined administration of Lactobacillus plantarum and Bifidobacterium bifidum (probiotic, BROB) on the passive avoidance test (Shuttle Box), choline acetyltransferase (ChAT) and the brain derived neurotrophic factor (BDNF) in the hippocampus of a rat model of AD. Read More

Neurosci Lett 2021 May 8:135946. Epub 2021 May 8.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Relapse to drugs such as opioids is a major challenge in addiction therapy. It has been known that the orexinergic system has a significant role in mediating reward processing and addiction, as shown by the conditioned place preference (CPP). The dentate gyrus (DG) of the hippocampus receives orexinergic projections from the lateral hypothalamus that has been approved as a critical area arbitrating the maintenance of drug-seeking behavior following the extinction. Read More

Int J Biol Macromol 2021 May 8. Epub 2021 May 8.

Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:

Intranasal (IN) administration, a non-invasive route, is explored to overcome the limitations of conventional subcutaneous (SC) injection for Japanese encephalitis (JE) immunisation. Mucoadhesive nanoparticles (NPs) are recognised for the benefits they offer via IN delivery, such as extended retention time of the vaccine on the mucosa. The purpose of this study was to evaluate immunisation effect of live attenuated Japanese encephalitis-chimeric virus vaccine (JE-CV)-loaded mucoadhesive NPs based on chitosan (CS) or chitosan maleimide (CM), a novel mucoadhesive polymer, via the IN route to improve the mucosal immunisation against JE. Read More

WMJ 2021 Apr;120(1):78-81

Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Introduction: Platelet-rich plasma (PRP) is a promising treatment for persistent symptoms caused by various musculoskeletal injuries, including tendinopathies.

Case Presentation: A 47-year-old woman presented with chronic left knee pain following a motor vehicle accident. Magnetic resonance imaging (MRI) revealed distal quadriceps tendinosis and a partial tear of the vastus intermedius tendon. Read More

Skin Res Technol 2021 May 11. Epub 2021 May 11.

Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.

Background: There is no non-invasive objective assessment tool to measure keloid scar characteristics over time. This study aimed to ascertain the ability of the Antera 3D camera to detect differences in keloid features pre- and post-steroid injection. In order to identify whether those variation could be considered as treatment response predicting factors. Read More

Acta Microbiol Immunol Hung 2021 May 8. Epub 2021 May 8.

3Emergency Medicine Department, Mehmet Akif Ersoy State Hospital, Canakkale, Turkey.

We aimed to monitor the adverse effects (AE) and efficacy of post exposure prophylaxis (PEP) in health care workers (HCWs) exposed to a rabies patient. In this study 109 HCWs and eight household contacts were PEP candidates. Contact persons without infection control precautions were in Group I (high risk-82 cases). Read More

Ocul Immunol Inflamm 2021 May 11:1-6. Epub 2021 May 11.

Department of Medical Microbiology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, Turkey.

: To evaluate the early efficacy of intrastromal injection of vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA).: Twenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was induced in the right eye of each rabbit. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):458-460

Department of Reproductive Medicine, Xiamen Maternal and Child Health Care Hospital, Women and Children's Hospital Affiliated to Xiamen University, Xiamen, Fujian 361000, China.

Objective: To explore the genetic basis for a patient with primary ciliary dyskinesia (PCD).

Methods: High-throughput sequencing and bioinformatic analysis were carried out to identify pathogenic variant in the patient. Suspected variant was verified by Sanger sequencing among the family members, and intracytoplasmic sperm injection (ICSI) was used to achieve the pregnancy. Read More

Eur Spine J 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.

Purpose: The purpose of this systematic review and meta-analysis was to determine whether epidural steroid injections (ESI) are superior to epidural or non-epidural placebo injections in sciatica patients.

Methods: The PubMed, Embase, Cochrane Library, and Web of science databases were searched for trials comparing ESI to epidural or non-epidural placebo. Risk of bias was assessed using the Cochrane RoB 2 tool. Read More

Brain 2021 May 11. Epub 2021 May 11.

Department of Biosciences, University of Milan, 20133, Milan, Italy.

Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its biosynthesis is severely reduced in mouse models of Huntington's disease. One possible mechanism is a diminished nuclear translocation of the transcription factor sterol regulatory element binding protein 2 (SREBP2) and, consequently, reduced activation of SREBP-controlled genes in the cholesterol biosynthesis pathway. Read More

Viral Immunol 2021 May 10. Epub 2021 May 10.

Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Papillomaviruses are placed within the family Papillomaviride, and the members of this family have a double-stranded circular DNA genome. Every year, ∼30% of cancers are reported to be human papillomavirus (HPV) related, which represents 63,000 cancers of all infectious agent-induced cancers. HPV16 and HPV18 are reported to be associated with 70% of cervical cancers. Read More

ACS Nano 2021 May 11. Epub 2021 May 11.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

Macrophages (MΦs) have the capability to sense chemotactic cues and to home tumors, therefore presenting a great approach to engineer these cells to deliver therapeutic agents to treat diseases. However, current cell-based drug delivery systems usually use commercial cell lines that may elicit an immune response when injected into a host animal. Furthermore, premature off-target drug release also remains an enormous challenge. Read More

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

Overexploitation of antibiotics increases the emergence of multidrug-resistant agents (MDRAs), which may potentially cause a global crisis with severe health consequences. Hence, there is great demand for next-generation antibacterial platforms based on antibiotic-free strategies or targeted therapies to mitigate the emergence of MDRAs. Herein, an all-in-one hollow nanoworm (A-Fe/AuAg@PDA) is developed with a core comprising citrate-capped Au-Ag nanoparticles (Cit-AuAg NPs) loaded with FeO and an l-arginine (L-Arg)-modified polydopamine (PDA) outer shell, possessing exceptional magnetic-targeting ability and a photothermal therapeutic effect. Read More

Laryngoscope 2021 May 11. Epub 2021 May 11.

Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington, U.S.A.

Intratympanic (IT) steroid therapy is a mainstay treatment for sudden sensorineural hearing loss (SSNHL) for both initial therapy and salvage therapy. We report a rare case of iatrogenic perilymphatic fistula that resulted from trauma during an IT steroid injection for SSNHL. We discuss the diagnosis and treatment in the current case and compare it with previous reports from the literature. Read More

ChemSusChem 2021 May 10. Epub 2021 May 10.

Uppsala University: Uppsala Universitet, Chemistry, SWEDEN.

Photoelectrochemical cell based on a semiconductor is among the most studied approach for artificial photosynthesis. Here, we investigated a recent concept based on the immobilization, on a mesoporous conducting ITO electrode (nano-ITO), of a molecular triad. The triad NDADI-P-Ru-TEMPO contained a ruthenium tris-bipyridine complex (Ru) as photosensitizer, which was connected in one end to 2,2,6,6-tetramethyl-1-piperidine N-oxyl (TEMPO) as alcohol oxidation catalyst, and in the other end to the electron acceptor naphthalene-dicarboxyanhydride-dicarboximide (NDADI). Read More

Pain Pract 2021 May 11. Epub 2021 May 11.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Objectives: Transforaminal epidural steroid injection (TFESI) is widely used to manage lumbosacral radicular pain due to herniated lumbar disc (HLD).

Objectives: We evaluated the long-term outcomes of TFESI in patients with lumbosacral radicular pain due to a HLD by the location, type, and size of the HLD.

Methods: In total, 114 patients who received the initial TFESI at least 4 years ago completed a phone interview. Read More

Environ Microbiol 2021 May 10. Epub 2021 May 10.

College of Fisheries, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education/Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, 430070, China.

Pancreatic ribonuclease (RNase1) of Megalobrama amblycephala exhibits both antimicrobial and digestive activity. The gut microbiome improved the digestion and metabolic capacity, and enhance the functioning of the immune system of the host against pathogenic bacteria. In this study, we aimed to assess the protective effect of RNase1 on Aeromonas hydrophila-induced inflammation and intestinal microbial metabolism. Read More

Oncologist 2021 May 11. Epub 2021 May 11.

3D Medicines Co., Ltd., Sichuan, People's Republic of China.

Lessons Learned: Subcutaneous injection was an effective route of administration for envafolimab with a favorable pharmacokinetic profile in patients with previously treated advanced solid tumors Subcutaneous envafolimab was well tolerated and had durable antitumor activity at a wide range of doses and schedules Envafolimab has the potential to be a more convenient option than currently approved intravenous PD-1/PD-L1 inhibitors BACKGROUND: Envafolimab is a novel fusion of a humanized single-domain PD-L1 antibody and human IgG1 Fc fragment formulated for subcutaneous injection. This study explored the safety and feasibility of subcutaneous administration of envafolimab as an alternative to intravenous administration of PD-1/PD-L1 inhibitors in the treatment of advanced, refractory solid tumors.

Methods: This was a first-in-human, open-label phase I trial. Read More

J Magn Reson Imaging 2021 May 11. Epub 2021 May 11.

Bracco Imaging SpA, Bracco Research Centre, Colleretto Giacosa, TO, Italy.

Background: Studies of gadolinium (Gd) clearance from animals in the first weeks after administration of gadolinium-based contrast agents (GBCAs) have previously looked at solitary timepoints only. However, this does not give information on differences between GBCAs and between organs in terms of Gd elimination kinetics.

Purpose: To compare Gd levels in rat cerebellum, cerebrum, skin, and blood at 1, 2, 3, and 5 weeks after repeated administration of macrocyclic GBCAs. Read More

Arch Insect Biochem Physiol 2021 May 11:e21795. Epub 2021 May 11.

Department of Plant Medicals, College of Life Sciences, Andong National University, Andong, Korea.

High-mobility group box 1 (HMGB1) is a nuclear protein highly conserved in eukaryotes and ubiquitously expressed to regulate transcription and chromatin remodeling. Dorsal switch protein 1 (DSP1) is its insect homolog. A lepidopteran DSP1 acts as a damage-associated molecular pattern (DAMP) in response to immune challenge. Read More

Adv Exp Med Biol 2021 ;1318:449-468

School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel zoonotic virus identified as the cause of coronavirus disease 2019 (COVID-19) that has crossed species and infected humans. In order to develop new insights on the immune-based treatments against this disease, it is vital to understand the immunopathology of the COVID-19, implications of the immune response to SARS-CoV-2, and immune dysfunction in response to SARS-CoV-2. There is no approved drug for the treatment of COVID-19. Read More

Neurol Sci 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: Severe low back pain (LBP) is an occasional complaint in patients with neuromuscular disorders (NMDs). Accurate diagnosis and treatment are required to manage LBP; however, the precise pathophysiology differs for each patient. This study aimed to evaluate the efficacy of lumbar facet joint denervation (FJD) and adjunctive modalities in the treatment of LBP in patients with NMD-associated kyphoscoliosis. Read More

Environ Monit Assess 2021 May 11;193(6):336. Epub 2021 May 11.

Department of Civil Engineering, East Tehran Branch, Islamic Azad University, Tehran, Iran.

Contamination of urban water distribution systems (WDS) is a critical issue due to the number of victims that might be impacted in a short period of time. Any effective rapid emergency response plan for reducing the number of sick people or deaths among those drinking the polluted water requires a reliable forecast of the water contamination zoning map (CZM). The water CZM is a visual representation of the spread of contamination at the time of contamination detection. Read More

Aesthetic Plast Surg 2021 May 10. Epub 2021 May 10.

Istanbul Okmeydani Training and Research Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, 34384, Istanbul, Turkey.

Purpose: Face rejuvenation procedures with injectable agents continue to gain popularity. Nowadays, a variety of commercial products are available as filler material. Ideal fillers should be inexpensive, easily obtainable, nontoxic, and biocompatible. Read More

J Mater Chem B 2021 May 11. Epub 2021 May 11.

Pharmaceutical Engineering Research Center, College of Pharmacy, Chongqing Medical University, Chongqing 400000, China.

Atherosclerosis (AS) is a major cause of cardiovascular diseases, but its effective theranostic measure remains challenging thus far. Macrophages contribute to AS progress in diverse ways such as producing cytokines and reactive oxygen species (ROS), foaming macrophages, and differentiating into pro-inflammatory macrophages. With the aim of constructing a facile and efficacious theranostic system for diagnosis and treatment of AS, a templated self-assembly approach was developed. Read More