12,417 results match your criteria Injecting Drug Use


Integrated and differentiated methadone and HIV care for people who use drugs: a qualitative study in Kenya with implications for implementation science.

Health Policy Plan 2019 Feb 20. Epub 2019 Feb 20.

Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.

Integrating methadone and HIV care is a priority in many low- and middle-income settings experiencing a growing challenge of HIV epidemics linked to injecting drug use. There is as yet little understanding of how to integrate methadone and HIV care in these settings and how such services can be implemented; such a gap reflects, in part, limitations in theorizing an implementation science of integrated care. In response, we qualitatively explored the delivery of methadone after its introduction in Kenya to understand integration with HIV care. Read More

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http://dx.doi.org/10.1093/heapol/czz002DOI Listing
February 2019

and its monomers alleviate liver fibrosis both in mice and LX2 cells by blocking TβR1-Smad2/3 and TNF-α-NF-κB pathways.

Am J Transl Res 2019 15;11(1):106-119. Epub 2019 Jan 15.

Medical College, Hubei University for Nationalities Enshi, Hubei, China.

This study aimed to investigate the protective effects, effective constituents and preliminary mechanisms of on liver fibrosis and screen new high-efficacy drug for fibrosis. 112 male C57BL/6 mice were randomly divided into 14 groups: control group (CG), CCL group (CTG), low/medium/high dose of ethanol extracts (EAE), catechin (CA), dihydroquercetin (DHQ) and kaempferol (KA) groups. The study lasted for 30 days by injecting CCL in peritoneal cavity to make fibrosis model, all mice were sacrificed to observe morphological changes and collagenous fiber by HE and Masson staining, to test liver index, ALT, AST, to measure the expression of α-SMA and collagen I by immunohistochemistry and western blotting, to discuss the pathways of TβR1-Smad2/3 and TNF-α-NF-κB by WB and Elisa; after being evaluated the efficacy, anti-fibrosis drug of highest efficacy was chosen to repeat these indexes in human hepatic stellate cells-LX2. Read More

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January 2019

Liver fibrosis is associated with cognitive impairment in people living with HIV.

Infection 2019 Feb 19. Epub 2019 Feb 19.

Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy.

Purpose: Our aim was to better explore the association between liver fibrosis (LF) and neurocognitive impairment (NCI) in people living with HIV (PLWH).

Methods: We performed a cross-sectional cohort study by consecutively enrolling PLWH at two clinical centers. All subjects underwent a comprehensive neuropsychological battery; NCI was defined as having a pathological performance (1. Read More

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http://link.springer.com/10.1007/s15010-019-01284-8
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http://dx.doi.org/10.1007/s15010-019-01284-8DOI Listing
February 2019
3 Reads

Effect of anti-inflammatory activity of ranolazine in rat model of inflammation.

Indian J Med Res 2018 Dec;148(6):743-747

Department of Pharmacology, Jawaharlal Nehru Medical College, Belagavi, India.

Background & Objectives: Inflammatory processes are a recognized feature of atherosclerotic lesions. Ranolazine inhibits the inflammatory markers such as C-reactive protein, interleukins-1 and -6 and tumour necrosis factor-alpha. The present study was planned to evaluate the effect of anti-inflammatory activity of ranolazine in acute and sub-acute models of inflammation in rats and compare the same with that of control (gum acacia 1%) and aspirin (standard anti-inflammatory drug). Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1504_16DOI Listing
December 2018

The critical role of injecting drug users on the spatial distribution of hepatitis C virus; a study in the West of Iran.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S129-S133

Deputy of Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: This study was conducted to provide a clear epidemiological picture of HCV spatial pattern.

Background: Hepatitis C virus (HCV) is one of the major problems of public health, that its spatial and spatiotemporal pattern remain unclear in Hamadan province.

Methods: We used the scan statistic to identify the spatial and spatiotemporal clusters of HCV in Hamadan province with an emphasis on considering the role of carrier's and injecting drug users (IDUs) cases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347991PMC
January 2018

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019
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Associations between impulsivity, risk behavior and HIV, HBV, HCV and syphilis seroprevalence among female prisoners in Indonesia: A cross-sectional study.

PLoS One 2019 15;14(2):e0207970. Epub 2019 Feb 15.

Department of Psychiatry, Division of Research, Radboud University Medical Center, Nijmegen, The Netherlands.

HIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior; however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to risk behavior, among female inmates living in a prison in Jakarta (N = 214). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207970PLOS
February 2019
1 Read

Effectiveness and framing of pharmaceutical opioid abuse-deterrent formulations.

Addiction 2019 Mar;114(3):404-405

National Drug and Alcohol Research Centre, University of New South Wales Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/add.14556DOI Listing
March 2019
2 Reads

The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses.

Sci Rep 2019 Feb 14;9(1):2090. Epub 2019 Feb 14.

Infectious Disease Epidemiology Group, Weill Cornell Medicine - Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar.

The objective was to delineate hepatitis C virus (HCV) epidemiology in countries of Central Asia (CA), specifically Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. A systematic review was conducted guided by the Cochrane Collaboration Handbook, and reported using PRISMA guidelines. Meta-analyses were performed using DerSimonian-Laird random-effects models with inverse variance weighting. Read More

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http://dx.doi.org/10.1038/s41598-019-38853-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376025PMC
February 2019
1 Read

A comparative study comparing area of extension of posterior knee capsule via posteromedial injection: a cadaveric study.

Eur J Orthop Surg Traumatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Periarticular multimodal drug injection (PMDI) has gained popularity as common postoperative pain protocols in knee arthroplasty. PMDI sites can vary, but posterior capsule (PC) is a common injection site because of its abundance of pain nociceptors.

Purpose: To prove the hypothesis whether posteromedial drug injection alone is sufficient to provide enough effect covering the PC in order to reduce risks of neurovascular injury. Read More

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http://dx.doi.org/10.1007/s00590-019-02399-2DOI Listing
February 2019
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A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.

J Int AIDS Soc 2019 Feb;22(2):e25222

Kirby Institute, UNSW, Sydney, NSW, Australia.

Introduction: Over the last two decades, the incidence of hepatitis C virus (HCV) co-infection among men who have sex with men (MSM) living with HIV began increasing in post-industrialized countries. Little is known about transmission of acute or recent HCV, in particular among MSM living with HIV co-infection, which creates uncertainty about potential for reinfection after HCV treatment. Using phylogenetic methods, clinical, epidemiological and molecular data can be combined to better understand transmission patterns. Read More

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http://dx.doi.org/10.1002/jia2.25222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371014PMC
February 2019
1 Read

[Prevalence of antiretroviral drug resistance in treatment-naive injecting drug users infected with HIV-1 in Guangzhou, 2008-2015].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):196-201

School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.

To understand the prevalence of drug resistance in treatment-naive injecting drug users (IDUs) infected with HIV-1 in Guangzhou. HIV-1 RNA were extracted from the serum specimens of the newly confirmed HIV-1 positive IDUs living in Guangzhou, being infected through injecting drug use and receiving no antiretroviral therapy at the time of confirmation during 2008-2015. Full sequence of protease (PR) gene and partial sequence of reverse transcriptase (RT) gene were amplified by nested reverse transcription polymerase chain reaction (nested-PCR) and sequenced. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.014DOI Listing
February 2019
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Priorities and recommended actions for how researchers, practitioners, policy makers, and the affected community can work together to improve access to hepatitis C care for people who use drugs.

Int J Drug Policy 2019 Feb 8;66:87-93. Epub 2019 Feb 8.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. Electronic address:

It is estimated that 6.1 million people with recent injecting drug use (PWID) are living with hepatitis C virus (HCV). Although HCV-related morbidity and mortality among PWID continues to increase, the advent of direct acting antiviral (DAA) HCV regimens with cure rates >95% provides an opportunity to reverse the rising burden of disease. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.01.012DOI Listing
February 2019
1 Read

Lumbar epidural blood patch: effectiveness on orthostatic headache and MRI predictive factors in 101 consecutive patients affected by spontaneous intracranial hypotension.

J Neurosurg 2019 Feb 8:1-9. Epub 2019 Feb 8.

1Functional Neurosurgery Unit.

OBJECTIVEAlthough epidural blood patch (EBP) is considered the gold-standard treatment for drug-resistant orthostatic headache in spontaneous intracranial hypotension (SIH), no clear evidence exists regarding the best administration method of this technique (blind vs target procedures). The aim of this study was to assess the long-term efficacy of blind lumbar EBP and predictors on preoperative MRI of good outcome.METHODSLumbar EBP was performed by injecting 10 ml of autologous venous blood, fibrin glue, and contrast medium in 101 consecutive patients affected by SIH and orthostatic headache. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181597DOI Listing
February 2019
1 Read

Pins and needles in the groin: an incidental finding of retained needle fragments in an intravenous drug user.

Authors:
Joshua Gladman

BMJ Case Rep 2019 Feb 6;12(2). Epub 2019 Feb 6.

Central and North West London NHS Foundation Trust, London, UK.

A female intravenous drug user was reviewed in A&E following a deliberate overdose. After claiming to have swallowed a razor blade, an abdominal radiograph was performed; this showed a linear metallic density projected over the right side of the pelvis, eventually identified as a needle fragment. Subsequent CT imaging revealed three additional needles situated within the groin. Read More

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http://dx.doi.org/10.1136/bcr-2018-226220DOI Listing
February 2019
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LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin.

Carbohydr Polym 2019 Apr 3;209:181-189. Epub 2019 Jan 3.

Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic.

A better understanding of in vivo behavior of nanocarriers is necessary for further improvement in their development. Here we present a novel approach, where both the matrix and the drug can be analyzed by LCMS/MS after one sample handling. The developed method was applied for the comparison of pharmacokinetic profile of free and encapsulated doxorubicin (DOX) in oleyl hyaluronan (HA-C18:1) polymeric micelles. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.12.104DOI Listing
April 2019
1 Read

Effects of CPEB1 in the anterior cingulate cortex on visceral pain in mice.

Brain Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, School of Pharmacy, and Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Patients with irritable bowel syndrome suffer from chronic visceral pain, and in some of them, this is accompanied by anxiety comorbidity. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the cytoplasmic polyadenylation of mRNAs and facilitates their translation. Our previous studies have shown that CPEB1 knockdown in the amygdala exerts anxiolytic but not analgesic effects in a mouse model of inflammatory pain. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.001DOI Listing
February 2019
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HIV risk behaviours among women who inject drugs in coastal Kenya: findings from secondary analysis of qualitative data.

Harm Reduct J 2019 Feb 6;16(1):10. Epub 2019 Feb 6.

Division of Health Research, University of Lancaster, Lancaster, LA1 4YW, UK.

Background: Injecting drug users are at high risk of HIV infection globally. Research related to female drug users is rare in Kenya, yet it is required to inform the development of gender-sensitive HIV prevention and harm reduction services in East Africa, where injecting drug use is on the rise.

Methods: This study aimed to document the nature of HIV risks encountered by women who inject drugs in the Mombasa and Kilifi, Kenya. Read More

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http://dx.doi.org/10.1186/s12954-019-0281-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364406PMC
February 2019
2 Reads

A global meta-analysis on HIV, hepatitis C and hepatitis B among people who inject drugs - do gender differences vary by country-level indicators?

J Infect Dis 2019 Feb 6. Epub 2019 Feb 6.

National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.

Background: Women-specific factors exist that increases vulnerability to drug-related harms from injecting drug use including bloodborne viruses (BBV), but gender differences in BBV prevalence have not been systematically examined.

Methods: We conducted meta-analyses to estimate country, regional, and global prevalence of serologically-confirmed HIV, hepatitis C (anti-HCV) and hepatitis B (HBsAg) prevalence in people who inject drugs (PWID) by gender. Gender differences in BBV (relative risks, RR in women vs men) were regressed on country-level prevalence and inequality measures. Read More

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http://dx.doi.org/10.1093/infdis/jiz058DOI Listing
February 2019
1 Read

Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function.

Zebrafish 2019 Feb 6. Epub 2019 Feb 6.

2 Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Chemical interventions are regularly used to examine and manipulate macrophage function in larval zebrafish. Given chemicals are typically administered by simple immersion or injection, it is not possible to resolve whether their impact on macrophage function is direct or indirect. Liposomes provide an attractive strategy to target drugs to specific cellular compartments, including macrophages. Read More

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http://dx.doi.org/10.1089/zeb.2018.1681DOI Listing
February 2019
2 Reads

Understanding HIV and hepatitis C virus risk among incarcerated young men with histories of injecting drug use.

Lancet Infect Dis 2019 Feb 30;19(2):130-131. Epub 2019 Jan 30.

Burnet Institute, Behaviours and Health Risks Program, Melbourne, VIC, Australia; Department of Public Health, La Trobe University, Bundoora, VIC, Australia.

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http://dx.doi.org/10.1016/S1473-3099(18)30801-6DOI Listing
February 2019
2 Reads

Age of Initiation and Patterns of Use among People Who Inject Drugs Welcomed in Harm Reduction Facilities in France from 2006 to 2015.

J Psychoactive Drugs 2019 Jan 31:1-12. Epub 2019 Jan 31.

a French Monitoring Centre for Drugs and Drug Addictions , Observatoire Français des Drogues et Toxicomanies (OFDT) , La Plaine Saint Denis Cedex , France.

This exploratory analysis of time-series cross-sectional data provides insights on trends in age at first injection among people who inject drugs in France, and on associations with recent risky injecting behaviors. Data were collected from a national survey conducted in harm reduction facilities in five phases between 2006 and 2015. Standardized questionnaires collected information on demographics, substance use, and route of administration, as well as lifetime and past-month injection. Read More

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https://www.tandfonline.com/doi/full/10.1080/02791072.2019.1
Publisher Site
http://dx.doi.org/10.1080/02791072.2019.1567960DOI Listing
January 2019
4 Reads

Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome.

J Biol Regul Homeost Agents 2019 Jan 30;33(1). Epub 2019 Jan 30.

Department of Traditional Chinese Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Gout is a common metabolic disease and acute gouty arthritis (AGA) is one of the important complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis, but the molecular mechanism has not been completely clarified. Thus, this study was aimed to explore the regulation of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important signaling pathways in inflammation. Read More

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January 2019
2 Reads

Trends in hepatitis B prevalence and associated risk factors among Indigenous and non-Indigenous prison entrants in Australia, 2004 to 2013.

Aust N Z J Public Health 2019 Jan 28. Epub 2019 Jan 28.

The Kirby Institute, University of New South Wales.

Objective This study describes and compares prevalence trends of markers for hepatitis B (HBV) from 2004 to 2013 and HBV risk factors between Indigenous and non-Indigenous prison entrants. Methods A cross-sectional survey carried out over two weeks in 2004, 2007, 2010 and 2013 in reception prisons in New South Wales, Queensland, Western Australia and Tasmania. Results The study included 2,223 prison entrants; 544 were Indigenous. Read More

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http://dx.doi.org/10.1111/1753-6405.12870DOI Listing
January 2019
1 Read

Emergence of Novel Psychoactive Substance injecting associated with rapid rise in the population prevalence of hepatitis C virus.

Int J Drug Policy 2019 Jan 25;66:30-37. Epub 2019 Jan 25.

Scottish Improvement Science Collaborating Centre, University of Dundee, UK.

Background: Novel Psychoactive Substance (NPS) use has increased in recent years and generated significant concern within public health. People who inject drugs (PWID) are at increased risk of blood borne viruses, in particular Hepatitis C virus (HCV). However, little is known about the extent of NPS injecting at a national level and its association with HCV. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.01.008DOI Listing
January 2019
1 Read

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy.

J Vis Exp 2019 Jan 10(143). Epub 2019 Jan 10.

Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital; Wound Healing Center, Peking University Third Hospital.

Chemical lumbar sympathectomy (CLS) is a commonly used, minimally invasive procedure for the treatment of conditions including ischemic diseases of the lower extremities, hyperhidrosis, etc. It is commonly practiced to position the puncture needle tip in front of the anterior fascia of the psoas major muscle and inject the inactivating agent around the sympathetic trunk, which is defined as conventional CLS. Although relatively rare, ureteropelvic damage is the most frequently reported complication of conventional CLS and can cause serious harm to patients. Read More

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http://dx.doi.org/10.3791/58894DOI Listing
January 2019
1 Read

Role of boyfriends and intimate sexual partners in the initiation and maintenance of injecting drug use among women in coastal Kenya.

Addict Behav 2019 Jan 17;93:20-28. Epub 2019 Jan 17.

Division of Health Research, University of Lancaster, United Kingdom. Electronic address:

Introduction: Gender dynamics and interpersonal relations within intimate partnerships are known to determine health behaviors, including substance use, within couples. In addition, influence from intimate partners may occur in the context of wider social ecological determinants of health behavior. The aim of this study was to document the role of intimate partners in influencing injecting drug use among women in Kenya, where injecting drug use is on the rise. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.01.013DOI Listing
January 2019
2 Reads

Outcomes of patients with a history of injecting drug use and receipt of outpatient antimicrobial therapy.

Eur J Clin Microbiol Infect Dis 2019 Mar 24;38(3):575-580. Epub 2019 Jan 24.

Infectious Diseases Department, Royal Brisbane and Women's Hospital, Herston, QLD, 4029, Australia.

People who inject drugs (PWID) are susceptible to endovascular and deep-seated infections which require prolonged antibiotic therapy. There are concerns regarding this cohort's suitability for outpatient parenteral antimicrobial therapy (OPAT), but relatively little published data. Our aim is to publish our outcomes in this setting, to inform other clinicians' decisions regarding PWID in OPAT. Read More

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http://dx.doi.org/10.1007/s10096-018-03461-3DOI Listing
March 2019
1 Read

The risks of HCV infection among Brazilian crack cocaine users: incorporating diagnostic test uncertainty.

Sci Rep 2019 Jan 24;9(1):443. Epub 2019 Jan 24.

Institute of Scientific and Technological Communication and Information in Health (ICICT), FIOCRUZ, Rio de Janeiro, Brazil.

Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general population. This study evaluate risk factors for HCV infection in users of crack/cocaine in Brazil, using multilevel models that incorporate variations in the sensitivity and specificity of the respective diagnostic tests. Read More

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http://dx.doi.org/10.1038/s41598-018-35657-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346030PMC
January 2019
1 Read

Estimating the Number of People Who Inject Drugs in A Rural County in Appalachia.

Am J Public Health 2019 Mar 24;109(3):445-450. Epub 2019 Jan 24.

Sean T. Allen, Rebecca Hamilton White, and Susan G. Sherman are with the Department of Health, Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. Allison O'Rourke is with the DC Center for AIDS Research, George Washington University, Washington, DC. Kristin E. Schneider is with the Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health. Michael Kilkenny is with the Cabell-Huntington Health Department, Huntington, WV.

Objectives: To demonstrate how we applied the capture-recapture method for population estimation directly in a rural Appalachian county (Cabell County, WV) to estimate the number of people who inject drugs (PWID).

Methods: We conducted 2 separate 2-week periods of data collection in June ("capture") and July ("recapture") 2018. We recruited PWID from a syringe services program and in community locations where PWID were known to congregate. Read More

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http://dx.doi.org/10.2105/AJPH.2018.304873DOI Listing
March 2019
3 Reads

Establishment of Effective Mouse Model of Premature Ovarian Failure Considering Treatment Duration of Anticancer Drugs and Natural Recovery Time.

J Menopausal Med 2018 Dec 31;24(3):196-203. Epub 2018 Dec 31.

Department of Obstetrics and Gynecology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Objectives: This study was aimed to establish the most effective premature ovarian failure (POF) mouse model using Cyclophosphamide (CTX), busulfan (Bu), and cisplatin considering treatment duration of anticancer drugs and natural recovery time.

Methods: POF was induced by intraperitoneally injecting CTX (120 mg/kg)/Bu (12 mg/kg) for 1 to 4 weeks or cisplatin (2 mg/kg) for 3 to 14 days to C57BL/6 female mice aged 6 to 8 weeks. Controls were injected with equal volume of saline for the same periods. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.6118/jmm.2018.24
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http://dx.doi.org/10.6118/jmm.2018.24.3.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336561PMC
December 2018
8 Reads

[Characteristics of HIV-infected persons without long term disease progress and related factors in Guangxi Zhuang Autonomous Region].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Jan;40(1):70-73

Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China.

To understand the characteristics of HIV infected persons without long term disease progress [also known as long term non-progressors (LTNPs)], and related factors in Guangxi Zhuang Autonomous Region (Guangxi). Data of persons living with HIV and receiving no antiretroviral therapy in Guangxi by the end of 2016 were collected from the national HIV/AIDS comprehensive control and prevention information system of China. By the end of 2016, there were 313 LTNPs in Guangxi, accounting for 2. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.01.014DOI Listing
January 2019
1 Read

People who inject drugs' experiences of skin and soft tissue infections and harm reduction: A qualitative study.

Int J Drug Policy 2019 Jan 18;65:65-72. Epub 2019 Jan 18.

School of Media, Culture and Society, University of the West of Scotland, Paisley, PA1 2BE, Scotland, United Kingdom.

Background: Bacterial skin and soft tissue infections (SSTI) among people who inject drugs (PWID) are considered a public health concern. There is a lack of qualitative research examining the lived experience of PWID who have had SSTI. This paper explores PWID views and experiences of their SSTI, their perceptions on the causes of their SSTI and their harm reduction (HR) behaviours. Read More

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http://dx.doi.org/10.1016/j.drugpo.2018.09.001DOI Listing
January 2019
5 Reads

Monitoring the hepatitis C epidemic in England and evaluating intervention scale-up using routinely collected data.

J Viral Hepat 2019 Jan 21. Epub 2019 Jan 21.

Statistics Modelling and Economics Department, National Infections Service Public Health England, London, UK.

In England, 160,000 individuals were estimated to be chronically infected with hepatitis C virus (HCV) in 2005 and the burden of severe HCV-related liver disease has increased steadily for the past 15 years. Direct-acting antiviral treatments can clear infection in most patients, motivating HCV elimination targets. However, the current burden of HCV is unknown and new methods are required to monitor progress. Read More

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http://doi.wiley.com/10.1111/jvh.13063
Publisher Site
http://dx.doi.org/10.1111/jvh.13063DOI Listing
January 2019
4 Reads

History of detention and the risk of hepatitis C among people who inject drugs in Germany.

Int J Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

Department for Infectious Disease Epidemiology, Division for HIV/AIDS, STI and Blood-borne Infections, Robert Koch Institute, Berlin, Germany. Electronic address:

Objectives: To investigate the association between detention experience and HCV status, the role of detention duration and frequency and whether risk behaviours practiced in detention could explain an observed increase in risk.

Methods: Current drug injectors (injecting in the last 12 months) were recruited to participate in a sero-behavioural, cross-sectional survey using respondent-driven sampling in eight German cities, 2011-2014. Using multivariable logistic regression the association between HCV status and reported detention experience was investigated. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.015DOI Listing
January 2019
3 Reads

A systematic, deep sequencing-based methodology for identification of mixed-genotype hepatitis C virus infections.

Infect Genet Evol 2019 Jan 14;69:76-84. Epub 2019 Jan 14.

BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.

Hepatitis C virus (HCV) mixed genotype infections can affect treatment outcomes and may have implications for vaccine design and disease progression. Previous studies demonstrate 0-39% of high-risk, HCV-infected individuals harbor mixed genotypes however standardized, sensitive methods of detection are lacking. This study compared PCR amplicon, random primer (RP), and probe enrichment (PE)-based deep sequencing methods coupled with a custom sequence analysis pipeline to detect multiple HCV genotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183058
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http://dx.doi.org/10.1016/j.meegid.2019.01.016DOI Listing
January 2019
9 Reads

Outcomes of treatment for hepatitis C in prisoners using a nurse-led, state-wide model of care.

J Hepatol 2019 Jan 14. Epub 2019 Jan 14.

Department of Gastroenterology, St Vincent's Hospital and the University of Melbourne, Australia. Electronic address:

Background: Treatment programs for people who inject drugs (PWID), including prisoners, are important for achieving hepatitis C elimination targets. There are multiple barriers to treatment of hepatitis C in prisons, including access to specialist physicians, testing and antiviral therapy, short prison sentences, and frequent inter-prison transfer. A state-wide program for assessment and management of hepatitis C was developed in Victoria, Australia to improve access to care for prisoners. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193002
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http://dx.doi.org/10.1016/j.jhep.2019.01.012DOI Listing
January 2019
4 Reads

Engaging people who inject drugs in hepatitis C virus testing and prevention through community-based outreach, in Sydney, Australia.

Drug Alcohol Rev 2019 Feb 16;38(2):177-184. Epub 2019 Jan 16.

The Kirby Institute, Faculty of Medicine, UNSW Sydney, Sydney, Australia.

Introduction And Aims: Increasing treatment uptake among people who inject drugs (PWID) with chronic hepatitis C virus (HCV) infection is integral to eliminating viral hepatitis. This study explored the role of community-based outreach in engaging and retaining Australian PWID in the testing component of the HCV care cascade.

Design And Methods: Semi-structured interviews were conducted with 28 PWID, including new initiates to injecting and those from culturally and linguistically diverse (CALD) backgrounds, who acquired HCV infection while enrolled in a community-based prospective observational study of hepatitis C vaccine preparedness in Sydney. Read More

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http://dx.doi.org/10.1111/dar.12895DOI Listing
February 2019
3 Reads

HIV knowledge and risk behaviors among drug users in three Vietnamese mountainous provinces.

Subst Abuse Treat Prev Policy 2019 Jan 15;14(1). Epub 2019 Jan 15.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Globally, people who inject drugs are highly vulnerable to HIV transmission. Methadone maintenance treatment (MMT) programs are one of the most cost-effective mechanisms to substitute opioid use and improve the quality of life of patients. Since the coverage of MMT is still limited and even for those patients who are treated, improving their knowledge on HIV and maintaining healthy behaviors are key to maximizing the outcomes of HIV harm reduction programs. Read More

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https://substanceabusepolicy.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s13011-019-0191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334422PMC
January 2019
10 Reads

Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities.

Int J Drug Policy 2019 Feb 12;64:95-102. Epub 2019 Jan 12.

University Hospital for Infectious Diseases "Dr. Fran Mihaljevic", School of Medicine, University of Zagreb, Mirogojska cesta 8, 10000 Zagreb, Croatia. Electronic address:

Background: Drug overdose is the major cause of morbidity and mortality among persons who inject drugs (PWID). We assessed factors associated with the non-fatal drug overdose among PWID in three Croatian cities and national trends of overdose-related mortality (OM), and rates of uptake of opioid agonist drug treatment (OAT).

Methods: We used a respondent-driven sampling method to recruit 830 PWID in Zagreb, Split and Rijeka in 2014/2015. Read More

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http://dx.doi.org/10.1016/j.drugpo.2018.11.017DOI Listing
February 2019
1 Read

Hepatitis B virus X reduces hepatocyte apoptosis and promotes cell cycle progression through the Akt/mTOR pathway in vivo.

Gene 2019 Apr 7;691:87-95. Epub 2019 Jan 7.

Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China; School of Pharmaceutical Science, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Hepatitis B virus X (HBx), a viral onco-protein encoded by HBV, can promote oncogenesis of HCC. However, the mechanism of HBx in hepatocarcinogenesis is still unclear. In this study, we establish a new mouse model with normal immune system to investigate the role of HBx and its functional mechanisms under normal immune function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193000
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http://dx.doi.org/10.1016/j.gene.2018.12.054DOI Listing
April 2019
5 Reads

Trends in gonorrhoea infection and overseas sexual contacts among females attending a sexual health centre in Melbourne, Australia, 2008-2015.

Commun Dis Intell (2018) 2018 17;42. Epub 2018 Dec 17.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.

Introduction: There has been a steady increase in gonorrhoea cases among females in Australian major cities but the reasons remain unclear. The aim of this study was to identify the risk factors associated with gonorrhoea among females attending a sexual health centre in Melbourne.

Methods: Analysis of retrospective electronic patient records of females aged 16 to 80 years old attending the Melbourne Sexual Health Centre, Australia between 1st January 2008 and 20th March 2015. Read More

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December 2018
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Offering HCV treatment to prisoners is an important opportunity: key principles based on policy and practice assessment in Europe.

BMC Public Health 2019 Jan 8;19(1):30. Epub 2019 Jan 8.

Addiction Treatment Centre, Biella, Italy.

Background: Prisoners have a high prevalence of hepatitis C virus (HCV) infection but may find it difficult to access healthcare services. This may be related to risk behaviour including history of injecting drugs and marginalisation related to problem drug use/ opioid use disorder (OUD). Direct-acting antiviral products with superior efficacy and safety compared to interferon-based regimens offer HCV cure. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-018-6357-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323720PMC
January 2019
7 Reads

Reasons for delayed antiretroviral therapy (ART) initiation in the era of early ART initiation guidelines: a retrospective service evaluation.

Int J STD AIDS 2019 Jan 8:956462418814985. Epub 2019 Jan 8.

3 St Mary's Hospital and Imperial College, London, UK.

Following changes in national antiretroviral therapy (ART) guidelines removing the CD4 threshold for initiation of ART, we evaluated the time to ART initiation and reasons for delayed or non-initiation. A retrospective notes review of 292 newly diagnosed HIV-positive individuals attending two London clinics between August 2015 and December 2016 was performed. Two hundred and fifty-four of 292 (87%) individuals started ART. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418814985
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http://dx.doi.org/10.1177/0956462418814985DOI Listing
January 2019
8 Reads

Improving the Predictions of Computational Models of Convection-Enhanced Drug Delivery by Accounting for Diffusion Non-gaussianity.

Front Neurol 2018 18;9:1092. Epub 2018 Dec 18.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United Kingdom.

Convection-enhanced delivery (CED) is an innovative method of drug delivery to the human brain, that bypasses the blood-brain barrier by injecting the drug directly into the brain. CED aims to target pathological tissue for central nervous system conditions such as Parkinson's and Huntington's disease, epilepsy, brain tumors, and ischemic stroke. Computational fluid dynamics models have been constructed to predict the drug distribution in CED, allowing clinicians advance planning of the procedure. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01092
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http://dx.doi.org/10.3389/fneur.2018.01092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305447PMC
December 2018
6 Reads

Practical steps to improve chronic hepatitis C treatment in people with opioid use disorder.

Hepat Med 2019 24;11:1-11. Epub 2018 Dec 24.

Spanish Society of Dual Diagnosis, Bilbao, Spain.

Objectives: People with a history of injecting drugs have high prevalence of hepatitis C virus (HCV) infection, and many have opioid use disorder (OUD). Modern HCV therapies with improved efficacy and tolerability are available, but access is often limited for this group, who may be underserved for health care and face social inequity. This work develops practical steps to improve HCV care in this population. Read More

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https://www.dovepress.com/practical-steps-to-improve-chronic
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http://dx.doi.org/10.2147/HMER.S187133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307489PMC
December 2018
8 Reads

Nicorandil abates arthritic perturbations induced by complete Freund's adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway.

Life Sci 2019 Feb 3;218:284-291. Epub 2019 Jan 3.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El Aini st., 11562 Cairo, Egypt; School of Pharmacy, Newgiza University, Cairo, Egypt. Electronic address:

Background And Purpose: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease which poses a need to explore effective yet safe pharmacotherapeutic options. The current work aimed to study the therapeutic role of nicorandil in controlling RA.

Experimental Approach: Complete Freund's adjuvant (CFA)-induced arthritis model was applied by injecting 400 μL of CFA in the right hind paw at day 0 and day 7. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.002DOI Listing
February 2019
2 Reads

Underreported injection drug use and its potential contribution to reported increase in sexual transmission of HIV in Kazakhstan and Kyrgyzstan.

Harm Reduct J 2019 Jan 5;16(1). Epub 2019 Jan 5.

ICAP at Columbia University, Allan Rosefield Building, 722 West 168th Street, Room 1310, New York, NY, USA.

Background: We conducted a cross-sectional integrated bio-behavioral survey among sex partners of persons who inject drugs (PWID) to explore reasons for reported increase in reporting of heterosexually transmitted HIV in Kazakhstan and Kyrgyzstan.

Methods: Sexual partners of PWID were recruited through PWID. Behavioral data were collected through semi-structured interviews. Read More

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http://dx.doi.org/10.1186/s12954-018-0274-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321689PMC
January 2019
2 Reads

The value of harm reduction for injection drug use: A clinical and public health ethics analysis.

Authors:
Laura Vearrier

Dis Mon 2018 Dec 29. Epub 2018 Dec 29.

Drexel University College of Medicine, 245N 15th Street, Mail Stop 1011, Philadelphia, PA 19102, United States. Electronic address:

The US is facing dual public health crises related to opioid overdose deaths and HIV. Injection drug use is fueling both of these epidemics. The War on Drugs has failed to stem injection drug use and has contributed to mass incarceration, poverty, and racial disparities. Read More

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http://dx.doi.org/10.1016/j.disamonth.2018.12.002DOI Listing
December 2018
6 Reads

HIV/AIDS epidemic in West Bengal: An overview.

J Family Med Prim Care 2018 Sep-Oct;7(5):898-902

Department of Community Medicine, Calcutta National Medical College, Kolkata, West Bengal, India.

Background: West Bengal is a low-prevalent state with high vulnerability for HIV. The state bears around 6% of HIV burden of India. With consistent effort on preventive, diagnostic, and curative services under National AIDS Control Program, HIV prevalence is gradually coming down. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_192_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259504PMC
January 2019
1 Read