24,194 results match your criteria Injecting Drug Use
J Antimicrob Chemother 2018 Dec 13. Epub 2018 Dec 13.
Institute for Global Health, University College London, London, UK.
Objectives: In subjects with transmitted thymidine analogue mutations (TAMs), boosted PIs (PI/b) are often chosen to overcome possible resistance to the NRTI backbone. However, data to guide treatment selection are limited. Our aim was to obtain firmer guidance for clinical practice using real-world cohort data. Read More
J Crohns Colitis 2018 Dec 13. Epub 2018 Dec 13.
Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Background And Aim: Penetrating disease is a common condition complicating Crohn's disease (CD). Establishing the presence of a fistula and the anatomical definition of the fistulous tracts are essential for deciding on appropriate treatment strategies. We aimed to assess the diagnostic accuracy of intra-cavitary contrast-enhanced ultrasound (IC-CEUS) for the detection of fistulous tract associated with abscesses in CD patients. Read More
Behav Brain Res 2018 Dec 10. Epub 2018 Dec 10.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:
Peripheral neuropathy is a common adverse effect observed during use of paclitaxel (PTX) as chemotherapy. The present investigation was directed to estimate the modulatory effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on pregabalin (PGB) treatment in PTX-induced peripheral neuropathy. Neuropathic pain was induced in rats by injecting PTX (2 mg/kg, i. Read More
Biochim Biophys Acta Mol Basis Dis 2018 Dec 10. Epub 2018 Dec 10.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA. Electronic address:
Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HKDC1 and 2-h plasma glucose in pregnant women from different ethnic backgrounds was shown. Our earlier work also reported diminished glucose tolerance during pregnancy in our whole body HKDC1 heterozygous mice. Read More
Turk J Med Sci 2018 12 12;48(6):1315-1320. Epub 2018 Dec 12.
Department of Neurosurgery, Faculty of Medicine, Dumlupınar University Kütahya, Turkey
Background/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drug
called brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats.
Materials And Methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4–2 μg of kainic acid into the rat hippocampus, was used. Read More
Can Fam Physician 2018 Dec;64(12):900-902
An 8-year-old child who lives in a small town has presented to my practice with a 3-inch laceration on the calf that has been assessed and needs repair with sutures. The family lives 4 hours from the nearest emergency department and I was planning to repair the wound in the office. What is the best way to manage pain in young patients needing sutures for laceration repair? Children are particularly susceptible to experiencing high levels of pain and anxiety during routine emergency procedures such as laceration repair. Read More
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1077-1082
Department of General Surgery, People's Hospital of Qinghai Province, Xining 810007, Qinghai, China (Zhu HH, Zhu WJ, Guo YM); Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China (Pan MS). Corresponding author: Guo Yamin, Email:
Objective: To observe the indexes of liver injury and the expression of inflammation-related factor interleukin-10 (IL-10) in rats with severe acute pancreatitis (SAP), and to discuss the correlation between the expression of IL-10 and the related factors of liver injury in SAP rats at different altitudes.
Methods: 280 male Wistar rats with SPF grade aged 5 to 6 months were divided into four groups according to random number table with 70 rats in each group, and the rats were placed in different altitudes such as Xi'an (at an altitude of 1 027 m), Xining (at an altitude of 2 260 m), Xinghai (at an altitude of 3 300 m) and Wenquan (at an altitude of 3 950 m). The rats in each altitude were randomly divided into sham operation group (Sham group, n = 10) and SAP 1, 6, 12, 24 hours groups (all n = 15). Read More
Front Neurosci 2018 22;12:845. Epub 2018 Nov 22.
Department of Neurosurgery, Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after spinal cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the differentiation of neurons and the outgrowth of neurites. Recently, exosomes have been used as novel biological vehicles to transfer miRNAs locally or systemically, but little is known about the effect of the delivery of exosome-mediated miRNAs on the treatment of SCI. Read More
Med Arch 2018 Nov;72(5):325-329
Gastroenterohepatology Research Center, Shiraz University of Medical of Sciences, Shiraz, Iran.
Introduction: Patients with drug addiction have high risk for hepatitis C virus (HCV). Effective treatment response is essential to optimize treatment for drug abusers infected by hepatitis C virus.
Aim: The aim of this present study was to show that hepatitis C treatment in patients with drug addiction is effective like patients without drug addiction. Read More
Phys Med Biol 2018 Nov 20. Epub 2018 Nov 20.
Department of Mathematics, Konkuk University, 93-1, Mojin-Dong, Kwangjin-Gu, Seoul, KOREA, seoul, KOREA, REPUBLIC OF.
Electrical brain stimulation (EBS) is a promising medical treatment method for brain neurological disorders through the direct or indirect excitation by injecting an electric current. At present, it is difficult to directly measure the distribution of the electric current delivered by electrodes inside tissues. By applying low-frequency ( < 1 kHz) external electrical brain stimulation (EBS), the low-frequency conductivity around the cells is uneven due to asymmetric cellular structures. Read More
Anal Bioanal Chem 2018 Dec 7. Epub 2018 Dec 7.
School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Oncolytic virotherapy is one of promising tumor therapy modalities. However, its therapeutic efficacy is still limited due to the immunogenicity and poor tumor-targeting capability. In this report, an engineered oncolytic vaccinia virus (OVV) was constructed by site-specifically introducing azide groups to the envelope of OVV during the in situ assembling process of virions. Read More
Sci Rep 2018 Dec 6;8(1):17691. Epub 2018 Dec 6.
Department of Petroleum Engineering, Curtin University, 26 Dick Perry Avenue, 6151, Kensington, Western Australia, Australia.
Injecting CO into oil reservoirs appears to be cost-effective and environmentally friendly due to decreasing the use of chemicals and cutting back on the greenhouse gas emission released. However, there is a pressing need for new algorithms to characterize oil/brine/rock system wettability, thus better predict and manage CO geological storage and enhanced oil recovery in oil reservoirs. We coupled surface complexation/CO and calcite dissolution model, and accurately predicted measured oil-on-calcite contact angles in NaCl and CaCl solutions with and without CO. Read More
Indian J Tuberc 2018 Oct 23;65(4):303-307. Epub 2018 Jul 23.
Community Medicine, Dr. Radhakrishanan Government Medical College, Hamirpur, Himachal Pradesh, India.
Background: Tuberculosis (TB) recurrence observed to be an important event in its treatment and has future implications under national TB control efforts. The present study was carried out to assess the recurrence rate along with its risk factors among patients undergoing treatment for TB under Revised National TB Control Program (RNTCP).
Material And Methods: Total 204 patients in health block of district Una, Himachal Pradesh were studied using pretested structured interviewer-administered questionnaire. Read More
Zhonghua Yu Fang Yi Xue Za Zhi 2018 Dec;52(12):1269-1275
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
To study the epidemiological characteristics and latent classes of non-marital heterosexual transmission among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) individuals in Jiangmen, Guangdong province between 2015 and 2017. HIV/AIDS cases from Chinese HIV/AIDS Comprehensive Response Information Management System were collected from January 1, 2015 to December 31, 2017. Inclusion criteria of HIV/AIDS were heterosexual transmission, non-marital heterosexual contact and older than 15 years. Read More
J Exp Clin Cancer Res 2018 Dec 11;37(1):307. Epub 2018 Dec 11.
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Background: The peritoneum is one of the most frequent metastatic sites in pancreatic cancer patients, and peritoneal dissemination makes this disease refractory due to aggressive progression and chemoresistance. Although the role of the tumor microenvironment in cancer development is recognized, the correlation between the peritoneal environment and refractoriness of peritoneal dissemination remains unclear. The intraperitoneal tumor-microenvironment and its potential role in the progression of peritoneal dissemination and chemo-refractoriness, focusing especially on macrophages, were investigated. Read More
World J Urol 2018 Dec 10. Epub 2018 Dec 10.
Fasa University of Medical Sciences, Fasa, Iran.
Purpose: Local injection of platelet-rich plasma (PRP) is postulated to work by delivering growth factors and cytokines that recruit healer cells and enhance recovery process at the injection site. As new scar formation leads to stricture recurrence after internal urethrotomy, we proposed to improve post-internal urethrotomy stricture recurrence rate by injecting local submucosal PRP at the time of urethrotomy.
Methods: From July 2015 to June 2018, 87 male patients with symptomatic bulbar urethral stricture (diagnosed by retrograde urethrography) randomized into two groups of internal urethrotomy and submucosal normal saline injection (control group, 43 patients), and internal urethrotomy with submucosal autologous platelet-rich plasma injection (PRP injection group, 44 patients). Read More
Mil Med 2018 Dec 7. Epub 2018 Dec 7.
University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH.
Introduction: Adequate oxygenation is one of the primary goals of mechanical ventilation. Maintenance of adequate oxygenation and prevention of hypoxemia are the primary goals for the battlefield casualty, but military operations have unique concerns. In military operations, oxygen is a limited resource. Read More
Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.
Chief of Division of Dental and Maxillofacial Surgery, G.B. Rossi Hospital and Medical University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Objective: Non-surgical rhinoplasty using injectable fillers, in contrast to traditional but more invasive surgery, offers low morbidity, improved skin quality and texture, cost-effectiveness and quick recovery. The aim of this study was to provide a valid and customized protocol for injecting the nose with the aid of a nasal grid to achieve constant attractive results.
Materials And Methods: From January 2015 and October 2018 150 consecutive patients entered the non-surgical rhinoplasty trial. Read More
Neural Regen Res 2019 Jan;14(1):107-113
Tianjin Third Central Hospital, Tianjin, China.
Many clinical studies have addressed the treatment of acute cerebral hemorrhage using acupuncture. However, few studies have examined the relationship between time of acupuncture and curative effect on cerebral hemorrhage. By observing the effect of acupuncture on changes in histopathology, ultrastructure, and neuroethology in a cerebral hemorrhage model of rats, we have directly examined the time-effect relationship of acupuncture. Read More
Philos Trans A Math Phys Eng Sci 2018 Dec 10;377(2137). Epub 2018 Dec 10.
NASA Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.
Carbon capture and storage is a transition technology from a past and present fuelled by coal, oil and gas and a planned future dominated by renewable energy sources. The technology involves the capture of carbon dioxide emissions from fossil fuel power stations and other point sources, compression of the CO into a fluid, transporting it and injecting it deep beneath the Earth's surface into depleted petroleum reservoirs and other porous formations. Once injected, the CO must be monitored to ensure that it is emplaced and assimilated as planned and that none leaks back to surface. Read More
Int J Infect Dis 2018 Dec 4. Epub 2018 Dec 4.
Division of Communicable Diseases, World Health Organization, Regional Office for the Western Pacific; Department of Microbiology, Peking University Health Science Center; Capital Medical University; Department of Hepatitis C and STD Prevention and Control, Chinese Center for Disease Control and Prevention; World Health Organization, Regional Office for the Americas.
Background And Aim: Chronic hepatitis C is a major global health challenge. China has the world's largest burden of hepatitis C and related liver disease, with several groups having an increased risk of acquiring hepatitis C virus (HCV) infection. We undertook a systematic review in Chinese and English literature to determine the seroprevalence of anti-HCV among men who have sex with men (MSM), sex workers, people who use drugs (PWUD) and migrant workers in China. Read More
J Cataract Refract Surg 2018 Dec 6. Epub 2018 Dec 6.
From Gimbel Eye Center, Calgary, Alberta, Canada. Electronic address:
We describe a new technique for capsule fixation of 1-piece acrylic toric intraocular lens (IOL) or other 1-piece acrylic IOLs in the presence of a large posterior capsule tear resulting in an open capsule. To keep the thick haptics out of the sulcus, reverse optic capture is necessary, with the haptics below the capsule and the optic edges above the capsule. This is done by placing the IOL in the sulcus and if it is a toric IOL, with the toric marks on the optic aligned with the corneal marks. Read More
Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.
To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More
Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3705-3710
Department of Pharmacy, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266071, China.
To investigate the effect and mechanisms of picroside Ⅱ on the brain tissue after cerebral ischemia reperfusion(I/R) in rats. The middle cerebral artery occlusion(MCAO) rat model was established by inserting a monofilament into middle cerebral artery. The experimental rats were treated by injecting picroside Ⅱ intraperitoneally. Read More
Langmuir 2018 Dec 10. Epub 2018 Dec 10.
Injecting a stream of micro-bubbles and thereby introducing a heterogeneous interface is proposed for enhancing nucleation and controlling particle formation in continuous microfluidic devices. Different gas and liquid flow rates were investigated to establish the two-phase flow regime map and to identify the optimum characteristics for micro-bubble flow. Subsequently, the effect of micro-bubbles was studied for the cooling crystallization of paracetamol. Read More
Microsurgery 2018 Dec 3. Epub 2018 Dec 3.
Department of Lymphatic and Reconstructive Surgery, Saiseikai Kawaguchi General Hospital, Saitama, Japan.
Background: Detecting more number of functional lymphatic vessels is the essential point in lymphaticovenous anastomosis (LVA). The purpose of this prospective study was to elucidate the efficacy of multi-area injection in indocyanine green (ICG) lymphography in LVA.
Methods: We injected ICG into the first web spaces of the feet or the second web space of the hands, subcutaneously. Read More
Inflammation 2018 Dec 1. Epub 2018 Dec 1.
Department of Emergency, People's Hospital of Ningxia Hui Autonomous Region, the First Affiliated Hospital of Northwest University for Nationalities, No.301 Zhengyuan North Street, Yinchuan, 750000, Ningxia, China.
To investigate the mechanism of Schisandrin B (Sch B) on the inflammation in LPS-induced sepsis. Sepsis mouse model was established by injecting LPS. qRT-PCR and western blot were used to measure the expression of miR-17-5p and TLR4. Read More
Addict Behav Rep 2018 Dec 25;8:170-175. Epub 2018 Sep 25.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, 21205, United States of America.
Introduction: Although the World Health Organization (WHO) has recommended guidelines for the treatment of opioid dependence, there are myriad challenges to successfully implementing such guidelines in resource constrained settings, such as in low and middle-income countries (LMICs). To highlight these challenges, this paper presents a clinical case study of an adolescent study participant in a randomized controlled trial comparing two counseling programs in Lusaka, Zambia.
Case Description: This 15 year-old male reported smoking marijuana and heroin daily, and injecting heroin monthly (while needle sharing). Read More
Neurosci Lett 2018 Nov 29. Epub 2018 Nov 29.
Departments of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, United States. Electronic address:
Orofacial muscle pain is a significant clinical problem because it affects eating, speaking, and other orofacial functions in patients. However, mechanisms underlying orofacial muscle pain are not fully understood. In the present study we induced orofacial muscle pain by injecting Complete Freund's Adjuvant (CFA) into masseter muscle of rats and assessed pain by the orofacial operant test. Read More
PLoS One 2018 5;13(12):e0207572. Epub 2018 Dec 5.
Department of Public Health, Patient Safety Research Center, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
Objectives: Injection safety during anesthesia is a challenging health care issue in Iranian hospitals. Anesthesia is one of the most medication-intensive procedures in healthcare and injecting patients are an integral part of that care. The present study aimed to assess the status of medication injection safety practice in a teaching center. Read More
Georgian Med News 2018 Oct(283):7-10
Kharkov Medical Academy of Postgraduate Education, Ukraine.
The problem of treating patients with loss of the skin and with a complicated course of the wound process remains topical. The problem is that, despite the relative technical simplicity of the dermatension method, the most significant complication is the decubitus of the stretchable flap, which is associated with a relatively high incidence of acute blood circulatory disturbances in the stretch tissues due to vascular compression with an excessive amount of injected fluid. The aim of the work is to improve the method of dermatension in reconstructive and recovery surgery of soft tissue defects of various genesis by planning and implementing dermatension at all its steps with instrumental control of the process using ultrasound and ICT in a complex. Read More
Eurasian J Med 2018 Oct;50(3):182-186
Department of Pharmacology, Çukurova University School of Medicine, Adana, Turkey.
Objective: Neuropathic pain (NP) is an inescapable stressor that significantly affects both the nervous and endocrine system functions. In this study, we investigated the effect of NP on female reproductive function using the number of oocytes as an index as well as the copulation rates of female mice, with and without males. We also examined whether NP symptoms stopped after injecting tramadol, an opioid analgesic. Read More
Harm Reduct J 2018 Dec 4;15(1):59. Epub 2018 Dec 4.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0507, USA.
Aim: Individuals experience differential risks in their initiation into drug injecting based on their gender. Data suggest women are more likely to be injected after their initiator and to share injection equipment. Little is known, however, regarding how gender influences the risk that people who inject drugs (PWID) may assist others into injection initiation. Read More
Harm Reduct J 2018 Dec 4;15(1):60. Epub 2018 Dec 4.
European Monitoring Centre for Drugs and Drug Addiction, Lisbon, Portugal.
Opioid agonist therapy (OAT) has been available in a standard regime in the Czech Republic since 2000. Buprenorphine is the leading medication, while methadone is available only in a few specialised centres. There is an important leakage of buprenorphine onto the illicit market, and the majority of Czech opioid users are characterised by the misuse (and injecting) of diverted buprenorphine medications. Read More
Int J Drug Policy 2018 Dec 1;63:74-89. Epub 2018 Dec 1.
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SN, United Kingdom. Electronic address:
Background: 'Chemsex' is the use of drugs before or during planned sexual events to facilitate, enhance, prolong and sustain the experience. Drugs associated with chemsex are methamphetamine, GHB/GBL, mephedrone, cocaine and ketamine. This review syntheses published research on the antecedents, behaviours and consequences associated with chemsex behaviours among men who have sex with men (MSM). Read More
Plast Reconstr Surg 2018 Nov;142(5):1219-1225
Pittsburgh, Pa. From the Department of Plastic Surgery, University of Pittsburgh Medical Center.
Background: Fat grafting has emerged as the treatment of choice for soft-tissue augmentation and reconstruction. Variability of volume retention remains the greatest challenge for this technique, often requiring multiple operations to achieve the desired volume. Graft that is placed greater than 2 mm from the recipient bed will undergo necrosis. Read More
Cell Transplant 2018 Dec 4:963689718817219. Epub 2018 Dec 4.
1 Department of Neurosurgery, Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Although microRNA-144-3p (miRNA-144-3p) has been shown to suppress tumor proliferation and invasion, its function in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) remains unclear. Thus, this study was designed to investigate the role of miRNA-144-3p in ICH. To accomplish this, we used adult male Sprague-Dawley rats to establish an in vivo ICH model by injecting autologous blood, while cultured primary rat cortical neurons were exposed to oxyhemoglobin (OxyHb) to mimic ICH in vitro. Read More
Drug Dev Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Gynaecology and Obstetrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Primary dysmenorrhea affects the quality of life in young women, particularly school and work performance. This study investigated the mechanisms of penehyclidine hydrochloride (PHC) efficacy on a rat model of primary dysmenorrhea. The model was induced by injecting both estradiol benzoate and oxytocin. Read More
J Am Soc Mass Spectrom 2018 Dec 3. Epub 2018 Dec 3.
Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.
Proton transfer reaction mass spectrometry (PTR-MS) usually detects different types of compounds by changing the discharge gas to produce different reagent ions in the ion source. In the present work, a novel method of changing reagent ions, ammonia-assisted PTR-MS, was developed. Through an injection port bypass, ammonia was injected into a homemade PTR-MS device. Read More
Pain Res Manag 2017 28;2017:3517207. Epub 2017 Dec 28.
Department of Biochemistry, College of Pharmacy, Al-Azhar University, Asyût, Egypt.
Background: Models of cancer-induced neuropathy are designed by injecting cancer cells near the peripheral nerves. The interference of tissue-resident immune cells does not allow a direct contact with nerve fibres which affects the tumor microenvironment and the invasion process.
Methods: Anaplastic tumor-1 (AT-1) cells were inoculated within the sciatic nerves (SNs) of male Copenhagen rats. Read More
Nat Commun 2018 12 3;9(1):5130. Epub 2018 Dec 3.
Department of Physics and Center for Functional Materials, Wake Forest University, Winston-Salem, North Carolina, 27109, USA.
Efficient injection of charge carriers from the contacts into the semiconductor layer is crucial for achieving high-performance organic devices. The potential drop necessary to accomplish this process yields a resistance associated with the contacts, namely the contact resistance. A large contact resistance can limit the operation of devices and even lead to inaccuracies in the extraction of the device parameters. Read More
EMBO Mol Med 2018 Dec 3. Epub 2018 Dec 3.
Molecular Biology of Cochlear Neurotransmission Group, Department of Otorhinolaryngology, University Medical Center Göttingen, and Collaborative Research Center 889, University of Göttingen, Göttingen, Germany
Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the gene encoding otoferlin, might be treated by transferring wild-type otoferlin cDNA into IHCs, which is difficult due to the large size of this transgene. In this study, we generated two adeno-associated viruses (AAVs), each containing half of the otoferlin cDNA Co-injecting these dual-AAV2/6 half-vectors into the cochleae of 6- to 7-day-old otoferlin knock-out () mice led to the expression of full-length otoferlin in up to 50% of IHCs. Read More
Cell Commun Signal 2018 Dec 3;16(1):93. Epub 2018 Dec 3.
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. Read More
Langmuir 2018 Dec 3. Epub 2018 Dec 3.
Over the past few decades, field and laboratory scale studies have shown enhancements in oil recovery when reservoirs, which contain high-salinity formation water (FW), are waterflooded with modified-salinity salt water (widely referred to as the "low-salinity", "dilution", or "SmartWater" effect for improved oil recovery). In this study, we investigated the time-dependence of the physico-chemical processes that occur during diluted seawater ( i.e. Read More
PLoS One 2018 30;13(11):e0207226. Epub 2018 Nov 30.
Centre for Social Research in Health, UNSW Sydney, Sydney, Australia.
Recent advances in the efficacy and tolerability of hepatitis C treatments and the introduction of a universal access scheme for the new Direct Acting Antiviral (DAA) therapies in March 2016, has resulted in a rapid increase in the uptake of hepatitis C treatment in Australia. Despite these positive developments, recent data suggest a plateauing of treatment numbers, indicating that more work may need to be done to identify and address ongoing barriers to hepatitis C treatment access and uptake. This paper aims to contribute to our understanding of the ongoing barriers to DAA therapies, with a focus on people who inject drugs. Read More
Transfusion 2018 Nov 30. Epub 2018 Nov 30.
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China.
Background: Transfusion-related acute lung injury (TRALI) is one of the most serious adverse events following transfusion, and there is no specific treatment in clinical practice. However, regulatory T cells (Tregs) have been suggested to play a potential role in the treatment of TRALI. This study investigated whether interleukin (IL)-2 or IL-2/anti-IL-2 complexes (IL-2c), which are mediators of Treg expansion, can modulate the severity of antibody-mediated TRALI in vivo. Read More
Vestn Oftalmol 2018 ;134(5):39-47
Institute of Physiology named after A.I. Karayev, 2 Sharifzadeh St., Baku, Republic of Azerbaijan, AZ1100.
Purpose: To study the molecular reparatory mechanisms of the retina and hypothalamus in the context of experimental dystrophy of receptor apparatus in rabbit retina.
Material And Methods: Retinal dystrophy was induced in rabbit eyes by injecting monoiodacetic acid (MIA) intravenously. Indirect ELISA test was used to evaluate the levels of rhodopsin, heat shock protein 70 kDa (HSP70) in the retina, and serotonin-modulating anticonsolidation protein (SMAP) - that directly correlates with serotonin level - in the hypothalamus. Read More
Vestn Oftalmol 2018 ;134(5. Vyp. 2):156-161
I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.
Numerous studies have demonstrated the efficacy of anti-VEGF medications for exudative (wet) age-related macular degeneration (AMD). Significant IOP elevation is one of the side effects of anti-VEGF intravitreal injection.
Purpose: To study the changes in the parameters of anterior segment of the eyeball against acute IOP elevation after repeated intravitreal injections (IVI) of anti-VEGF medication. Read More
Arch Virol 2018 Nov 29. Epub 2018 Nov 29.
Department of Biology, Faculty of Science, Karadeniz Technical University, 61080, Trabzon, Turkey.
The genome of Chilo iridescent virus (CIV) has two open reading frames (ORFs) with matrix metalloprotease (MMP) domains. The protein encoded by ORF 136R contains 178 amino acids with over 40% amino acid sequence identity to hypothetical metalloproteases of other viruses, and the protein 165R contains 264 amino acids with over 40% amino acid sequence identity to metalloproteases of a large group of organisms, primarily including a variety of Drosophila species. These proteins possess conserved zinc-binding motifs in their catalytic domains. Read More
Bioinformatics 2018 Nov 29. Epub 2018 Nov 29.
LISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Motivation: Structure-based Computational Protein design (CPD) plays a critical role in advancing the field of protein engineering. Using an all-atom energy function, CPD tries to identify amino acid sequences that fold into a target structure and ultimately perform a desired function. Energy functions remain however imperfect and injecting relevant information from known structures in the design process should lead to improved designs. Read More