13,610 results match your criteria Injecting Drug Use

Frequent Cannabis Use Is Negatively Associated with Frequency of Injection Drug Use Among People Who Inject Drugs in a Canadian Setting.

Cannabis Cannabinoid Res 2020 Oct 21. Epub 2020 Oct 21.

British Columbia Centre on Substance Use, Vancouver, Canada.

High levels of morbidity and mortality associated with injection drug use continue to represent a significant public health challenge in many settings worldwide. Previous studies have shown an association between cannabis use and decreased risk of some drug-related harms. We sought to evaluate the association between high-intensity cannabis use and the frequency of injection drug use among people who inject drugs (PWID). Read More

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October 2020

Agent-based evolving network modeling: a new simulation method for modeling low prevalence infectious diseases.

Health Care Manag Sci 2021 May 15. Epub 2021 May 15.

Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA.

Agent-based network modeling (ABNM) simulates each person at the individual-level as agents of the simulation, and uses network generation algorithms to generate the network of contacts between individuals. ABNM are suitable for simulating individual-level dynamics of infectious diseases, especially for diseases such as HIV that spread through close contacts within intricate contact networks. However, as ABNM simulates a scaled-version of the full population, consisting of all infected and susceptible persons, they are computationally infeasible for studying certain questions in low prevalence diseases such as HIV. Read More

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Structural competency in the post-prison period for people who inject drugs: A qualitative case study.

Int J Drug Policy 2021 May 11;95:103261. Epub 2021 May 11.

Behaviours and Health Risks Program, Burnet Institute, Melbourne, Victoria, Australia; National Drug Research Institute, Curtin University, Melbourne, Victoria, Australia.

Introduction: Access to services is key to successful community (re-)integration following release from prison. But many people experience disengagement from services, including people who inject drugs (PWID). We use a case study approach and the notion of structural competency to examine influences on access to services among a group of PWID recently released from prison. Read More

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The Mechanism of Lavender Essential Oil in the Treatment of Acute Colitis Based on "Quantity-Effect" Weight Coefficient Network Pharmacology.

Front Pharmacol 2021 22;12:644140. Epub 2021 Apr 22.

Department of Pharmaceutics, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

This study aimed to introduce a new weight coefficient combined with network pharmacology to predict the potential active components, action targets, and signal pathways of lavender essential oil and to investigate the therapeutic effect of lavender essential oil on colitis through animal experiments. The component targets of lavender essential oil were mined from the Pubchem and SwissTargetPrediction databases, and the relative content of lavender essential oil was compared with OB (oral bioavailability) to establish a "quantity-effect" weight coefficient. Online databases such as GeneCards and String were used to construct a "lavender essential oil compound target disease target" network to extract the key targets of core compounds acting on diseases. Read More

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A Systematic Review of Interventions Used to Increase Blood Donor Compliance with Deferral Criteria.

Transfus Med Hemother 2021 Mar 23;48(2):118-129. Epub 2020 Jul 23.

Burnet Institute, Melbourne, Victoria, Australia.

Background And Objectives: Pre-donation screening of potential blood donors is critical for ensuring the safety of the donor blood supply, and donor deferral as a result of risk factors is practised worldwide. This systematic review was conducted in the context of an expert review convened by the Australian Red Cross Lifeblood in 2013 to consider Lifeblood's injecting drug use (IDU)-related policies and aimed to identify studies assessing interventions to improve compliance with deferral criteria in blood donation settings.

Materials And Methods: MEDLINE/PubMed, OVID Medline, OVID Embase, LILACS, and the Cochrane Library (CENTRAL and DARE) databases were searched for studies conducted within blood donation settings that examined interventions to increase blood donor compliance with deferral criteria. Read More

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Explaining the Differences in Opioid Overdose Deaths between Scotland and England/Wales: Implications for European Opioid Policies.

Eur Addict Res 2021 May 7:1-14. Epub 2021 May 7.

Department of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Backgrounds: Between 2009 and 2018, the number of opioid-related deaths (ORDs) in Scotland showed a dramatic increase, whereas in England and Wales, a much lower increase in ORD was seen. This regional difference is remarkable, and the situation in Scotland is worrisome. Therefore, it is important to identify the drivers of ORD in Scotland. Read More

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Evaluation of hepatitis C treatment-as-prevention within Australian prisons (SToP-C): a prospective cohort study.

Lancet Gastroenterol Hepatol 2021 Jul 7;6(7):533-546. Epub 2021 May 7.

The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia. Electronic address:

Background: Limited empirical evidence exists for the effectiveness of hepatitis C virus (HCV) treatment-as-prevention. The Surveillance and Treatment of Prisoners with hepatitis C (SToP-C) study aimed to assess the effect of HCV treatment-as-prevention in the prison setting.

Methods: SToP-C was a prospective study, including a before-and-after analysis, within a cohort of people incarcerated in two maximum-security prisons (male) and two medium-security prisons (one male, one female) in New South Wales, Australia. Read More

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Determinants of loss to care and risk of clinical progression in PLWH who are re-engaged in care after a temporary loss.

Sci Rep 2021 May 5;11(1):9632. Epub 2021 May 5.

National Institute for Infectious Diseases 'L. Spallanzani', Via Portuense 292, 00149, Rome, Italy.

The risk of developing AIDS is elevated not only among those with a late HIV diagnosis but also among those lost to care (LTC). The aims were to address the risk of becoming LTC and of clinical progression in LTC patients who re-enter care. Patients were defined as LTC if they had no visit for ≥ 18 months. Read More

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The association between use of chemsex drugs and HIV clinic attendance among gay and bisexual men living with HIV in London.

HIV Med 2021 May 5. Epub 2021 May 5.

Institute for Global Health, University College London, London, UK.

Objectives: To investigate the association between chemsex drug use and HIV clinic attendance among gay and bisexual men in London.

Methods: A cross-sectional survey of adults (> 18 years) diagnosed with HIV for > 4 months, attending seven London HIV clinics (May 2014 to August 2015). Participants self-completed an anonymous questionnaire linked to clinical data. Read More

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The Methyl Ester of 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid Reduces Endometrial Lesions Development by Modulating the NFkB and Nrf2 Pathways.

Int J Mol Sci 2021 Apr 13;22(8). Epub 2021 Apr 13.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Endometriosis is a common gynecological disease. Here, we aimed to investigate the anti-fibrotic, anti-inflammatory, and anti-oxidative role of the methyl ester of 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO-Me) on endometriosis. An endometriosis rat model was constructed by intraperitoneally injecting recipient rats with an equivalent of tissue from the uterus of a donor animal. Read More

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Wounds and Skin and Soft Tissue Infections in People Who Inject Drugs and the Utility of Syringe Service Programs in Their Management.

Adv Wound Care (New Rochelle) 2021 Jun 14. Epub 2021 Jun 14.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Opioid use disorder and transition to injection drug use (IDU) are an urgent, nationwide public health crisis. Wounds and skin and soft tissue infections (SSTIs) are common complications of IDU that disproportionately affect people who inject drugs (PWID) and are a major source of morbidity and mortality for this population. Injections in a nonsterile environment and reusing or sharing needles facilitates bacterial inoculation, with subsequent risk of serious complications such as sepsis, gangrene, amputation, and death. Read More

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Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp.

Front Pharmacol 2021 12;12:649414. Epub 2021 Apr 12.

Department of Medical Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes. Read More

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Naloxone for opioid toxicity and overdose in the community.

Aust Prescr 2021 Apr 1;44(2):38-39. Epub 2021 Apr 1.

Uniting Medically Supervised Injecting Centre, Sydney.

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Whole genome sequencing of a clinical drug resistant isolate reveals known and novel mutations in genes involved in resistance acquisition mechanisms.

J Med Microbiol 2021 Apr;70(4)

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 32300 Pilsen, Czech Republic.

is an opportunistic pathogen accounting for the majority of cases of infections. Currently, are developing resistance towards different classes of antifungal drugs and this has become a global health burden that does not spare Lebanon. This study aims at determining point mutations in genes known to be involved in resistance acquisition and correlating resistance to virulence and ergosterol content in the azole resistant isolate CA77 from Lebanon. Read More

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Outcomes of Methadone Maintenance Therapy Combined with Rilpivirine /Efavirenz in Treatment-naive HIV-infected Patients.

Curr HIV Res 2021 Apr 23. Epub 2021 Apr 23.

Antiviral Clinic Department, Yunnan Infectious Disease Hospital, Kunming, China.

Background: Injecting drugs is associated with a high risk of HIV infection, alongside the risk of a drug overdose and mental health problems.

Objective: To evaluate the effect of methadone maintenance treatment (MMT) combined with rilpivirine (RPV)-based regimens on drug use of HIV individuals.

Methods: This study was a prospective, open-label, controlled, drug-drug interaction trial at a single center for 24 weeks. Read More

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Molecular structure analysis and biological properties investigation on antiseptic drug; 2-amino-1-phenyl-1-propanol using spectroscopic and computational research analysis.

Heliyon 2021 Apr 7;7(4):e06699. Epub 2021 Apr 7.

Department of Physics, ST. Theresa's Arts and Science College, Tharangambadi, Tamilnadu, India.

The inducement of physical, chemical, structural and biological properties to entice of pharmaceutical property was analyzed by Vibrational spectroscopic, biological and theoretical tools. The structural arrangement for describing structure activity was investigated by injecting ligand groups in internal coordinate system by molecular tools (FT adopted IR, Raman, and NMR). Bond length and bond angle strain was pronounced much due to the chemical equivalent forces extension due to the injection of substitutional groups on base compound and thus non-Centro symmetry was processed. Read More

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The current paradigm for biologic initiation: a mixed-methods exploration of practices, unmet needs, and innovation opportunities in self-injection training.

Expert Opin Drug Deliv 2021 Jun 8:1-18. Epub 2021 Jun 8.

Matchstick LLC, Boonton, NJ, USA.

: Self-injection, particularly of biologics, has become a mainstay of chronic disease management. Despite labeling requirement for healthcare provider (HCP) training, current injection initiation experiences have been shown to be suboptimal. This study characterizes gaps in training and support during initiation and identifies rationales to inform solutions. Read More

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Shenmai injection improves doxorubicin cardiotoxicity via miR-30a/Beclin 1.

Biomed Pharmacother 2021 Jul 23;139:111582. Epub 2021 Apr 23.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

Background: Shenmai Injection (SMI) has been widely used in the treatment of cardiovascular diseases and can reduce side effects when combined with chemotherapy drugs. However, the potential protective mechanism of SMI on the cardiotoxicity caused by anthracyclines has not been clear.

Methods: We used network pharmacology methods to collect the compound components in SMI and myocardial injury targets, constructed a 'drug-disease' target interaction network relationship diagram, and screened the core targets to predict the potential mechanism of SMI in treating cardiotoxicity of anthracyclines. Read More

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A Case Report of Wound Botulism - Rare Disease on the Rise with the Opioid Crisis.

Hawaii J Health Soc Welf 2021 Feb;80(4):88-91

Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (WH).

Wound botulism is a rare, underrecognized life-threatening illness caused by a toxin produced by Clostridium botulinum, a spore-forming anaerobic bacterium. Approximately 20 cases are reported in the United States each year, mostly from California. Most wound botulism cases occur in drug injectors, particularly among those using black tar heroin. Read More

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February 2021

Patient-reported outcomes of the Treatment and Prevention Study: A real-world community-based trial of direct-acting antivirals for hepatitis C among people who inject drugs.

J Viral Hepat 2021 Jul 3;28(7):1068-1077. Epub 2021 May 3.

Burnet Institute, Melbourne, Vic., Australia.

The impact of hepatitis C cure with direct-acting antivirals (DAAs) on patient-reported outcomes (PROs) in community settings remains unclear. We aimed to assess changes in PROs over time and whether treatment was associated with sustained improved PROs in a cohort of people who inject drugs. This study is a sub-analysis of the Treatment and Prevention Study, a nurse-led trial where people who inject drugs and their injecting partners were recruited in a community setting, in Melbourne, Australia. Read More

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Changing epidemiology and viral interplay of hepatitis B, C and D among injecting drug user-dominant prisoners in Taiwan.

Sci Rep 2021 Apr 20;11(1):8554. Epub 2021 Apr 20.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.

The spreading of viral hepatitis among injecting drug users (IDU) is an emerging public health concern. This study explored the prevalence and the risks of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) among IDU-dominant prisoners in Taiwan. HBV surface antigen (HBsAg), antibodies to HCV (anti-HCV) and HDV (anti-HDV), viral load and HCV genotypes were measured in 1137(67. Read More

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Can locally developed me-too drugs aid price negotiation? An example of cancer therapies from China.

Semin Oncol 2021 Apr 6. Epub 2021 Apr 6.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Rapid growth in pharmaceutical expenditures and high prices have greatly hampered access to medicines, especially targeted anticancer medicines. Confronted with such difficulties, the Chinese government has put more effort into supporting local research and development of cancer medicines, resulting in locally developed me-too drugs. Since 2016, the government has implemented a central reimbursement-linked drug price negotiation policy aimed at reducing the prices of expensive medicines. Read More

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A Multistage Process Model of How a Person Who Currently Injects Drugs Comes to Assist Persons Who Do not Inject with Their First Injections.

Front Sociol 2021 15;6:619560. Epub 2021 Feb 15.

Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.

Injecting drugs for the first time almost always requires assistance from an experienced person who injects drugs (PWID). While there has been moderate amount of research on PWID who assist with first injections, most of this research has focused on identifying characteristics of PWID who assist with first injections. We do not have a formal model that describes how the minority of PWID come to assist do so, while the majority never assist. Read More

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February 2021

Associations Between Childhood Trauma and the Age of First-Time Drug Use in Methamphetamine-Dependent Patients.

Front Psychiatry 2021 26;12:658205. Epub 2021 Mar 26.

Chaohu Hospital, Anhui Medical University, Hefei, China.

Childhood trauma is related to substance use disorder; however, few studies have examined the relationship between childhood trauma and the age at which the drug was first used. The aim of this study was to investigate the relationship between childhood trauma and the age of first-time drug use among methamphetamine-dependent patients. Moreover, we analyzed the characteristics of adverse family environment associated with severe childhood trauma and the risk factors for starting drugs in minors. Read More

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Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory and Cognitive Impairment Induced by Multiple Cerebral Infarctions.

Evid Based Complement Alternat Med 2021 30;2021:6648455. Epub 2021 Mar 30.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

This study aimed to illustrate the mechanism by which Shenmayizhi decoction (SMYZD) improves the learning memory of rats with vascular cognitive impairment (VCI). Fifty male and female Wistar rats of specific pathogen-free grade (SPF grade) were used to establish the model by the administration of a microsphere embolization. This was accomplished by injecting sterile, standardized, mass-produced microspheres of uniform particle size (100-200 m in diameter) in a sodium alginate microsphere vascular embolic agent suspension to induce VCI. Read More

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Possible Prosthetic Valve Endocarditis by and Specific Virulence Mechanisms.

Infect Drug Resist 2021 6;14:1319-1324. Epub 2021 Apr 6.

University Hospital Zurich, Department of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland.

Bacteremia by spp. has rarely been described before. We report the first case of a possible prosthetic valve endocarditis, according to the modified Duke criteria, in a 37-year old male injecting drug user suffering from recurrent endocarditis. Read More

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Prevalence and correlates of multiple non-fatal opioid overdoses among people who inject drugs who utilise needle syringe programs in Australia.

Int J Drug Policy 2021 Apr 8:103245. Epub 2021 Apr 8.

The Kirby Institute, UNSW Sydney, Sydney, Australia; The Burnet Institute, Melbourne, Australia. Electronic address:

Background: Non-fatal overdose (NFOD) is a major cause of morbidity among people who inject drugs (PWID) and multiple NFOD is associated with increased risk of fatal overdose. Despite this, few studies have examined the prevalence and correlates of drug-specific multiple NFOD. The current study aimed to determine the prevalence and correlates of recent multiple non-fatal opioid overdose (NFOOD) among PWID who access needle syringe programs (NSPs) in Australia. Read More

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Size Does Matter - Intervention in Right-Sided Endocarditis.

Heart Lung Circ 2021 May;30(5):629-630

Austin & St Vincent's Hospitals, Melbourne University, Melbourne, Vic, Australia; Deakin University, Geelong & Melbourne, Vic, Australia; Oregon Health and Science University, Portland, OR, USA; University of Illinois at Urbana-Champaign, Champaign, IL, USA. Electronic address:

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Socioeconomic stability is associated with lower injection frequency among people with distinct trajectories of injection drug use.

Int J Drug Policy 2021 Apr 8;94:103205. Epub 2021 Apr 8.

Research Centre, Centre Hospitalier de l'Université de Montréal, 900 St Denis Street, Montréal, Québec H2X 3H8, Canada; Department of Family and Emergency Medicine, Université de Montréal, 2900, Édouard-Montpetit Boulevard, Montréal, Québec H3T 1J4, Canada. Electronic address:

Background: Little is known about how socioeconomic circumstances relate to injection frequencies among people who inject drugs (PWID) with diverse trajectories of injection. We aimed to characterize trajectories of injection drug use in a community-based sample of PWID over 7.5 years and to investigate the extent to which two modifiable factors reflecting socioeconomic stability-stable housing and stable income-relate to injection frequencies across distinct trajectories. Read More

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Intravenous versus oral omeprazole on patients with high risk bleeding peptic ulcers: A prospective randomized clinical trial protocol.

Medicine (Baltimore) 2021 Apr;100(14):e25136

Department of Gastroenterology, Jiangjin District Central Hospital, Chongqing, China, 402260.

Background: Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omeprazole vs intravenous omeprazole in decrease of rebleeding of peptic ulcer patients.

Method: The present study was authorized by the local research ethics committee of Jiangjin District Central Hospital (2020120987) and informed consent was obtained from all patients. Read More

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