166 results match your criteria Injectable Bulking Agents for Incontinence


Sexual Function Following Treatment for Stress Urinary Incontinence With Bulk Injection Therapy and Mid-Urethral Sling Surgery.

J Sex Med 2022 May 11. Epub 2022 May 11.

Amsterdam UMC, University of Amsterdam, Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development research institute, Amsterdam, The Netherlands; Bergman Clinics, Department of Gynaecology, Bergman Vrouwenzorg, Amsterdam, The Netherlands.

Background: Peri-urethral bulking injections (PBI) gain popularity for the treatment of stress urinary incontinence (SUI), but - in contrast to mid-urethral sling (MUS) surgery - little is known about its impact on sexual function.

Methods: This was a secondary analysis of a prospective cohort study that included patients with moderate to severe SUI undergoing either MUS surgery or PBI with polydimethylsiloxane Urolastic (PDMS-U). The validated Dutch and English version of the 'Pelvic Organ Prolapse and/or Urinary Incontinence Sexual Function Questionnaire - IUGA Revised' (PISQ-IR) was used to assess sexual function at baseline, at 6 and 12 months of follow-up. Read More

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Current Concepts in Endoscopic Bladder Neck Injection: Combined Antegrade and Retrograde Endoscopic Injection of the Bladder Neck in Children with Neurogenic Bladder.

Children (Basel) 2022 Mar 23;9(4). Epub 2022 Mar 23.

Department of Pediatric Surgery, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.

Introduction: Urinary incontinence is common in patients with neurogenic bladder, and efficient management is an ongoing challenge. Besides open surgical procedures like bladder neck reconstruction, artificial sphincter implantation, or sling procedures, endoscopic bladder neck injections of bulking agents enable minimally invasive access with promising results. Several studies report on the effect of antegrade vs. Read More

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Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence.

Cochrane Database Syst Rev 2022 03 29;3:CD012457. Epub 2022 Mar 29.

Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Background: Surgical options for treating stress urinary incontinence (SUI) are usually explored after conservative interventions have failed. Surgeries fall into two categories: traditional techniques (open surgery) and minimally invasive procedures, such as laparoscopic procedures, midurethral sling and injections with urethral bulking agents. Postsurgery infections, such as infections of the surgical site or urinary tract, are common complications. Read More

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The new therapeutic option for female stress and stress-predominant mixed urinary incontinence: Periurethral hypertonic saline (10%) injection.

Low Urin Tract Symptoms 2022 May 12;14(3):186-192. Epub 2021 Dec 12.

Department of Urology, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey.

Objectives: We aimed to evaluate the safety and efficacy of periurethral hypertonic saline (10% NaCl) injection in the treatment of stress urinary incontinence (SUI) and stress-predominant mixed urinary incontinence (S-MUI) in women.

Methods: This was a prospective study conducted between January 2014 and April 2018 with 64 women (44 SUI and 21 S-MUI). Patients with SUI and S-MUI were evaluated using the Urinary Distress Inventory 6. Read More

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Injection of Aluminum Potassium Sulfate and Tannic Acid in the Treatment of Fecal Incontinence: A Single-Center Observational Study.

Ann Coloproctol 2021 Jul 21. Epub 2021 Jul 21.

Department of Proctology, Kunimoto Hospital, Asahikawa, Hokkaido, Japan.

Purpose: Perianal injection of bulking agents is an attractive treatment option for patients with mild to moderate fecal incontinence (FI). Various bulking agents have been used for injection therapy, but the optimal injection materials and methods are yet to be standardized. This study aimed to evaluate the effects of injection therapy using aluminum potassium sulfate and tannic acid (ALTA) in the management of FI. Read More

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Clinical presentation and treatment of Macroplastique® urethral exposures: a retrospective case series.

Int Urogynecol J 2022 Mar 2;33(3):681-687. Epub 2021 Jul 2.

Department of Gynecology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA.

Introduction And Hypothesis: Manufacturers of Macroplastique® for urethral bulking have not previously reported exposures as potential complications. This study was aimed at identifying presenting symptoms, management, and outcomes in patients experiencing urethral or bladder exposures.

Methods: A retrospective case series from 2010 to 2019 was performed in an academic affiliated hospital system. Read More

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Comparative effectiveness of biofeedback and injectable bulking agents for treatment of fecal incontinence: Design and methods.

Contemp Clin Trials 2021 08 15;107:106464. Epub 2021 Jun 15.

Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, United States of America.

Fecal incontinence (FI), the involuntary passage of stool, is common and can markedly impair the quality of life. Among patients who fail initial options (pads or protective devices, bowel modifying agents, and pelvic floor exercises), the options are pelvic floor biofeedback (BIO), perianal injection with bulking agents (INJ), and sacral nerve electrical stimulation (SNS), which have not been subjected to head-to-head comparisons. This study will compare the safety and efficacy of BIO and INJ for managing FI. Read More

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Comparison of antegrade and retrograde endoscopic injection techniques for neurogenic sphincteric incontinence in children with neurogenic bladder.

J Pediatr Urol 2021 08 26;17(4):526.e1-526.e6. Epub 2021 May 26.

Division of Pediatric Surgery, Necker Hospital for Sick Children, Paris, France.

Introduction/background: Urinary incontinence is common in children with neuropathic bladder. Results of endoscopic injections of bulking agents in the bladder neck are promising but it remains unclear whether they should be performed an antegrade or retrograde fashion.

Objective: Our aim was to compare the antegrade and retrograde endoscopic injection techniques for the treatment of urinary incontinence. Read More

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Urethral bulking agents for the treatment of stress urinary incontinence in women: A systematic review.

Neurourol Urodyn 2021 08 20;40(6):1349-1388. Epub 2021 May 20.

Department of Urology, Western Health, St Albans, Victoria, Australia.

Aims: To perform a systematic review to assess and compare the efficacy and safety of all urethral bulking agents (UBAs) available for the treatment of stress urinary incontinence (SUI) in women.

Methods: This systematic review was conducted in accordance with the PRISMA guideline. A systematic search was conducted using the Ovid Medline, Embase and PubMed databases. Read More

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Gastrointestinal dysfunction in movement disorders.

Authors:
Ryuji Sakakibara

Neurol Sci 2021 Apr 4;42(4):1355-1365. Epub 2021 Feb 4.

Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, 285-8741, Japan.

Purpose Of Review: This article provides an overview of the clinical presentation, investigations, and treatment options for gastrointestinal tract (GIT) dysfunction in patients with Parkinson's disease (PD) and other movement disorders.

Recent Findings: GIT dysfunction commonly appears as constipation and fecal incontinence (mostly overflow, accompanied with sphincter failure in multiple system atrophy [MSA]). Bowel dysfunction (underactive) occurs irrespectively from the site of the neurologic lesion, which is in contrast to site-dependent bladder dysfunction (brain, overactive; periphery, underactive). Read More

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Easy way to treat female stress urinary incontinence with bulking agents (with video).

J Gynecol Obstet Hum Reprod 2021 Mar 6;50(3):102061. Epub 2021 Jan 6.

Department of Gynecology, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, Hospices civils de Lyon, 69000 Lyon, France.

Since the recent controversy about vaginal mesh implants, surgeons should use safe and effective devices and procedures to treat female stress urinary incontinence (SUI). We propose to describe the noninvasive and ambulatory technique of the urethral bulking procedure. Bulking agents are a simple, minimally invasive technique that can be offered in the treatment of female SUI. Read More

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Seven-year efficacy and safety outcomes of Bulkamid for the treatment of stress urinary incontinence.

Neurourol Urodyn 2021 01 7;40(1):502-508. Epub 2021 Jan 7.

Section of Urogynecology and Pelvic Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA.

Aims: Bulking agents are a minimally invasive treatment option for women with stress urinary incontinence (SUI) or stress-predominant mixed urinary incontinence (MUI). The aim of this study was to evaluate long-term efficacy and safety following treatment with Bulkamid as a primary procedure for SUI or stress-predominant MUI.

Methods: This was an Institutional Review Board-approved single-center retrospective study of female patients with SUI or stress-predominant MUI who had undergone injection with Bulkamid since 2005 and had completed 7 years of follow up. Read More

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January 2021

Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence.

Acta Biomater 2020 11 6;117:156-166. Epub 2020 Oct 6.

Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, China. Electronic address:

Injection of urethral bulking agents is a low-risk, minimally invasive surgical procedure to treat stress urinary incontinence (SUI). In this study, we developed a promising injectable bulking agent comprising extracellular matrix fragments of adipose-derived stem cell sheets (ADSC ECM) and investigated its effectiveness in urethral bulking therapy. The structural integrity and proteins of ADSC sheet ECM were well retained in decellularized ADSC ECM fragments. Read More

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November 2020

Artificial urinary sphincter: current status and future directions.

Authors:
Culley C Carson

Asian J Androl 2020 Mar-Apr;22(2):154-157

Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Urge urinary incontinence (UUI) is one of the most troublesome complications of surgery of the prostate whether for malignancy or benign conditions. For many decades, there have been attempts to reduce the morbidity of this outcome with variable results. Since its development in the 1970s, the artificial urinary sphincter (AUS) has been the "gold standard" for treatment of the most severe cases of UUI. Read More

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February 2021

Management of erectile dysfunction and LUTS/incontinence: the two most common, long-term side effects of prostate cancer treatment.

Can J Urol 2020 02;27(27 Suppl 1):17-24

Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. Read More

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February 2020

Lower Urinary Tract and Bowel Dysfunction in Neurologic Disease.

Continuum (Minneap Minn) 2020 02;26(1):178-199

Purpose Of Review: This article provides an overview of the clinical presentation, investigations, and treatment options for lower urinary tract and bowel dysfunction in patients with neurologic diseases.

Recent Findings: The site of the neurologic lesion influences the pattern of lower urinary tract dysfunction. Antimuscarinic agents are first-line management for urinary incontinence; however, the side effect profile should be considered when prescribing them. Read More

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February 2020

Middle-term Outcomes of Gatekeeper Implantation for Fecal Incontinence.

Dis Colon Rectum 2020 04;63(4):514-519

Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences, General, Mini-invasive and Obesity Surgery Unit, University of Campania "Luigi Vanvitelli," Naples, Italy.

Background: Intersphincteric injectable bulking agents are one of the current treatment options for fecal incontinence, failing behavioral and medical therapy. Gatekeeper showed promising short-term results, but long-term outcomes are unknown.

Objective: The purpose of this study was to clinically evaluate a prospective cohort of fecal incontinence patients up to 36 months after implantation of Gatekeeper. Read More

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Regenerative medicine and injection therapies in stress urinary incontinence.

Nat Rev Urol 2020 03 23;17(3):151-161. Epub 2020 Jan 23.

Royal Hallamshire Hospital, Glossop Road, Sheffield, UK.

Stress urinary incontinence (SUI) is a common and bothersome condition. Anti-incontinence surgery has high cure rates, but concerns about mesh tapes have resulted in the resurgence of surgical procedures that involve increased abdominopelvic dissection and morbidity. Injection therapy with urethral bulking agents or stem cell formulations have been developed as minimally invasive alternatives. Read More

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Urinary Incontinence in Women: Evaluation and Management.

Am Fam Physician 2019 09;100(6):339-348

Winn Army Community Hospital, Fort Stewart, GA, USA.

Urinary incontinence is a common problem among women worldwide, resulting in a substantial economic burden and decreased quality of life. The Women's Preventive Services Initiative is the only major organization that recommends annual screening for urinary incontinence in all women despite low to insufficient evidence regarding effectiveness and accuracy of methods. No other major organization endorses screening. Read More

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September 2019

The use of urethral bulking injections in post-prostatectomy stress urinary incontinence: A narrative review of the literature.

Neurourol Urodyn 2019 11 20;38(8):2060-2069. Epub 2019 Aug 20.

Department of Urology, St George's NHS Foundation Trust, London, UK.

Aims: Post-prostatectomy stress urinary incontinence (PPI) is a common condition with significant impact on patient quality of life. With rising numbers of prostatectomies performed, recognition of incontinence during survivorship care is growing. With increasing hesitance of the use of suburethral mesh in females, urethral bulking injections in this patient population as a minimally invasive alternative to surgery are evaluated. Read More

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November 2019

Effectiveness of Autologous Fat Graft in Treating Fecal Incontinence.

Ann Coloproctol 2019 Jun 30;35(3):144-151. Epub 2019 Jun 30.

Department of Surgery, Busan Hangun Hospital, Busan, Korea.

Purpose: The most common risk factor for fecal incontinence (FI) is obstetric injury. FI affects 1.4%-18% of adults. Read More

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Complications of urethral bulking therapy for female stress urinary incontinence.

Neurourol Urodyn 2019 08 8;38 Suppl 4:S12-S20. Epub 2019 May 8.

Department of Urology, University of Illinois at Chicago (UIC), Chicago, Illinois.

Aims: To review, report, and discuss the complications associated with urethral bulking therapy in female stress urinary incontinence.

Methods: An extensive nonsystematic literature review on complications associated with injectable bulking agents used in the clinical practice was conducted. We reviewed articles published in English and indexed in the PubMed, Embase, and Google Scholar databases. Read More

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Surgery for urinary incontinence in women: Report from the 6th international consultation on incontinence.

Neurourol Urodyn 2019 02 4;38(2):825-837. Epub 2018 Dec 4.

Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

Urinary incontinence is a prevalent condition worldwide and causes a tremendous impact on a woman's quality of life. While conservative and non-surgical therapies are options for treatment, surgery for stress urinary incontinence (SUI) is common. Options include colposuspension, slings (pubovaginal and midurethral), and periurethral bulking. Read More

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February 2019

Injection of Urethral Bulking Agents.

Urol Clin North Am 2019 Feb;46(1):1-15

Urinary Tract and Pelvic Reconstruction, Department of Urology, MD Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Urethral injection is a safe and minimally invasive method of treating female stress urinary incontinence with multiple bulking agents currently commercially available. Although there are numerous studies that demonstrate efficacy, long-term success is not yet proven. This article aims to describe the mechanism of action and properties of various agents, patient selection factors, available techniques for injection, outcomes of urethral injections, and complications associated with the procedure. Read More

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February 2019

Can Urethral Bulking Agents Salvage Failed Slings?

Urology 2019 Feb 7;124:78-82. Epub 2018 Nov 7.

Michigan Medicine University of Michigan, Ann Arbor, MI.

Objective: To evaluate the efficacy of urethral bulking agents for stress urinary incontinence (SUI) in the setting of prior failed sling.

Methods: This is a retrospective review of patients who underwent urethral bulking agent injections for a primary complaint of SUI following prior failed sling surgery. The outcomes assessed were patient reported improvement, need for further interventions for incontinence and validated questionnaires. Read More

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February 2019

Retrospective analysis after endoscopic urethral injections of glutaraldehyde-cross-linked-collagen or dextranomer/hyaluronic acid copolymer in bitches with urinary incontinence.

J Small Anim Pract 2019 Feb 2;60(2):96-101. Epub 2018 Nov 2.

EVIDENSIA Tierärztliche Klinik für Kleintiere Norderstedt GmbH, 22850 Norderstedt, Germany.

Objectives: To evaluate the outcome of endoscopic injection of two different bulking agents, glutaraldehyde cross-linked collagen and dextranomer/hyaluronic acid copolymer into the urethral submucosa in female dogs with urinary incontinence caused by urethral sphincter mechanism incompetence.

Materials And Methods: Retrospective review of records and follow-up communication with owners of dogs that received an endoscopically guided urethral bulking procedure. In each dog, either cross-linked collagen (2007 to 2011) or dextranomer/hyaluronic acid copolymer (2012 to 2015) was used. Read More

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February 2019

Efficacy and safety of polydimethylsiloxane injection (Macroplastique ) for the treatment of female stress urinary incontinence: results of a series of 85 patients with ≥3 years of follow-up.

BJU Int 2019 02 16;123(2):353-359. Epub 2018 Oct 16.

Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Objective: To assess the long-term efficacy and safety of polydimethylsiloxane injection (Macroplastique , Cogentix Medical, Orangeburg, New York, USA) for the treatment of female stress urinary incontinence (SUI), with a minimum follow-up of 3 years.

Patients And Methods: This is an observational analytical prospective cohort study conducted in a single uro-gynaecological unit. All consecutive women with urodynamically confirmed pure SUI treated with the Macroplastique procedure, were included. Read More

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February 2019

Urolastic®, a new bulking agent for treatment of stress urinary incontinence: a systematic review and meta-analysis.

Int Urogynecol J 2018 09 23;29(9):1239-1247. Epub 2018 Jun 23.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 12, 07100, Sassari, Italy.

Introduction And Hypothesis: The aim of the present systematic review and meta-analysis was to assess the effectiveness and safety of injections of the new bulking agent Urolastic® in the treatment of patients with stress urinary incontinence (SUI).

Methods: A systematic search was carried out to select observational and experimental studies on Urolastic® in female patients with SUI. Three different databases, Pubmed, the Cochrane Central Register of Controlled Trials, and Scopus, were used to retrieve scientific articles published from their inception to 31 January 2018. Read More

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September 2018

CT and MR Imaging Features of Artificial Urinary Sphincters, Penile Prostheses, and Other Devices in the Male Lower Genitourinary Tract.

Radiographics 2018 May-Jun;38(3):794-805

From PENRAD Imaging and Colorado Springs Radiologists, Colorado Springs, Colo (E.T.C.); and Departments of Radiology (P.R., E.S.S.) and Urology (W.I.J.), Hospital of the University of Pennsylvania, 3400 Spruce St, MRI 1 Founders, Philadelphia, PA 19104-4283.

Urinary incontinence and erectile dysfunction are relatively common conditions in the aging male population. Surgical interventions for urinary incontinence include placement of an artificial urinary sphincter (AUS), perineal sling, or sacral nerve stimulator and injections of periurethral bulking agents. Erectile dysfunction can be treated surgically with placement of a penile prosthesis. Read More

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October 2018

Face, Content, and Construct Validations of Endoscopic Needle Injection Simulator for Transurethral Bulking Agent in Treatment of Stress Urinary Incontinence.

J Surg Educ 2018 Nov 3;75(6):1673-1678. Epub 2018 May 3.

Department of Urology, Division of Female Urology, Pelvic Reconstruction Surgery & Voiding Dysfunction University of California, Irvine, California. Electronic address:

Introduction And Objectives: Endoscopic injection of urethral bulking agents is an office procedure that is used to treat stress urinary incontinence secondary to internal sphincteric deficiency. Validation studies important part of simulator evaluation and is considered important step to establish the effectiveness of simulation-based training. The endoscopic needle injection (ENI) simulator has not been formally validated, although it has been used widely at University of California, Irvine. Read More

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November 2018