389,892 results match your criteria Injectable Bulking Agents for Incontinence


Identifying Potentially Modifiable Factors Associated with Treatment Non-Adherence in Paediatric Growth Hormone Deficiency: A Systematic Review.

Horm Res Paediatr 2018 Dec 6;90(4):1-7. Epub 2018 Dec 6.

Background: Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence.

Methods: A search of 11 electronic databases was undertaken to identify relevant articles, published in English, between 1985 and 2018. Read More

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December 2018
2 Reads

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

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December 2018
3 Reads

Hydrogels with prolonged release of therapeutic antibody: Block junction chemistry modification of 'ABA' copolymers provides superior anticancer efficacy.

J Control Release 2018 Dec 3. Epub 2018 Dec 3.

31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

In this study, we report a new series of vitamin E-functionalized 'ABA' triblock copolymers with carbamate block junction, which can form hydrogen-bonds. These polymers were synthesized via solvent- and catalyst-free nucleophilic addition between PEG-diamine and vitamin E-functionalized cyclic carbonate. The catalyst-free synthesis enabled an easy purification step and recycling of excess monomers. Read More

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December 2018
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Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos.

Islets 2018 Dec 6:1-18. Epub 2018 Dec 6.

a Institute of Molecular Biology/CMBI , University of Innsbruck , Innsbruck , Austria.

Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca sensor in pancreatic β-cells to monitor a key step in glucose induced insulin secretion; the elevations of intracellular [Ca]. Read More

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December 2018
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Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

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December 2018
4 Reads

Electrophysiological Properties of Identified Oxytocin and Vasopressin Neurons.

J Neuroendocrinol 2018 Dec 6:e12666. Epub 2018 Dec 6.

Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO.

To understand the contribution of intrinsic membrane properties to the different firing patterns of oxytocin (OT) and vasopressin (VP) neurons in vivo, in vitro studies are needed, where stable intracellular recordings can be made. Combining immunochemistry for OT and VP and intracellular dye injections allows characterization of identified OT and VP neurons, and several differences between the two cell types have emerged. These include a greater transient K current that delays spiking to stimulus onset, and a higher Na current density leading to greater spike amplitude and a more stable spike threshold, in VP neurons. Read More

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December 2018
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Incidence of adverse events attributable to bupivacaine liposome injectable suspension or plain bupivacaine for postoperative pain in pediatric surgical patients: a retrospective matched cohort analysis.

Paediatr Anaesth 2018 Dec 6. Epub 2018 Dec 6.

Departments of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States.

Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by the U.S Food and Drug Administration for local infiltration in adults. Read More

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December 2018

Efficacy of a polyvalent injectable vaccine against Flavobacterium psychrophilum administered to rainbow trout (Oncorhynchus mykiss L.).

J Fish Dis 2018 Dec 6. Epub 2018 Dec 6.

Institute of Aquaculture, University of Stirling, Stirling, UK.

Flavobacterium psychrophilum is one of the most important pathogens affecting cultured rainbow trout (Oncorhynchus mykiss). Recent information from UK salmonid farms showed country-wide distribution of genetically and serologically divergent clones, which has hampered the development of a vaccine for rainbow trout fry syndrome. The current study assessed the efficacy of an injectable polyvalent vaccine containing formalin-inactivated F. Read More

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December 2018
2 Reads

A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurophysiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen - the Netherlands.

Background: Neurons in the supragranular layers of the somatosensory cortex integrate sensory (bottom-up) and cognitive/perceptual (top-down) information as they orchestrate communication across cortical columns. It has been inferred, based on intracellular recordings from juvenile animals, that supragranular neurons are electrically mature by the fourth postnatal week. However, the dynamics of the neuronal integration in the adulthood is largely unknown. Read More

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December 2018
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Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease.

Cardiol Young 2018 Dec 6:1-4. Epub 2018 Dec 6.

Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More

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December 2018

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.

Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.

Acute Geriatrics Unit, Monza (MB). Italy.

Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

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December 2018

Therapeutic strategies for skin regeneration based on biomedical substitutes.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, E-18071, Spain.

Regenerative medicine and tissue engineering (TE) have experienced significant advances in the development of in vitro engineered skin substitutes, either for replacement of lost tissue in skin injuries or for the generation of in vitro human skin models to research. However, currently available skin substitutes present different limitations such as expensive costs, abnormal skin microstructure and engraftment failure. Given these limitations, new technologies, based on advanced therapies and regenerative medicine, have been applied to develop skin substitutes with several pharmaceutical applications that include injectable cell suspensions, cell-spray devices, sheets or 3D-scaffolds for skin tissue regeneration and others. Read More

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December 2018
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Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Background: Astrocyte elevated gene-1 (AEG-1), also known as metadherin, 3D3, and lysine-rich carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) coisolated, has emerged as an important oncogene that is overexpressed in a variety of cancers. Previous studies revealed that AEG-1 is also involved in multiple physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine, and Huntington's disease. However, the function of AEG-1 in diabetic cardiomyopathy (DCM) has not been reported yet. Read More

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December 2018

Ultrasound-guided selective nerve root block versus fluoroscopy-guided interlaminar epidural block for the treatment of radicular pain in the lower cervical spine: a retrospective comparative study.

J Ultrasound 2018 Dec 5. Epub 2018 Dec 5.

Department of Physical Medicine and Rehabilitation, Sanggye Paik Hospital, Inje University College of Medicine, Sanggye 7 dong 761-7, Nowon-gu, 139-707, Seoul, South Korea.

Purpose: Recent studies have compared the therapeutic efficacy and safety of the procedure using ultrasound and fluoroscopy. However, there are no published studies comparing the therapeutic efficacy and safety of fluoroscopy (FL)-guided cervical interlaminar epidural steroid injection (CIESI) with that of ultrasound (US)-guided selective nerve root block (SNRB). This study aimed to compare the mid-term effects and advantages of US-guided SNRB with FL-guided CIESI for radicular pain in the lower cervical spine through assessment of pain relief and functional improvement. Read More

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December 2018

Efficacy of external cold and a vibrating device in reducing discomfort of dental injections in children: A split mouth randomised crossover study.

Eur Arch Paediatr Dent 2018 Dec 5. Epub 2018 Dec 5.

Department of Paediatric Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Aim: To study the discomfort and fear associated with maxillary infiltration injections when using a combination of external cold and a commercially available vibrating device.

Methodology: A total of 60 children aged 7 years old participated in this split mouth randomised crossover study. The control intervention comprised of the administration of 1. Read More

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December 2018
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Severe Familial Hypertriglyceridemia: Successful Treatment With Insulin and a Modified Meal Plan.

J Endocr Soc 2018 Dec 1;2(12):1357-1362. Epub 2018 Nov 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Context: Mutations in genes encoding the lipoprotein lipase enzyme, its cofactor, or transport proteins can cause severe familial hypertriglyceridemia, resulting in serious complications, such as severe pancreatitis, hepatosplenomegaly, lipid encephalopathy, and failure to thrive. Current treatment includes a low-saturated-fat formula enriched with high medium-chain triglyceride (TGs), oral fibrates, omega-3 fatty acids, or plasmapheresis.

Case Description: A 71-day-old infant with very severe hypertriglyceridemia and recurrent pancreatitis associated with a likely pathogenic variant in the gene was treated successfully with insulin infusion and a locally prepared low-fat formula feed after stopping breast milk. Read More

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December 2018
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Closed-Loop Intravenous Drug Administration Using Photoplethysmography.

IEEE J Transl Eng Health Med 2018 1;6:4300108. Epub 2018 Nov 1.

Department of Biomedical EngineeringUniversity of UtahSalt Lake CityUT84112USA.

An optically-based injection control system has been developed for preclinical use for an intravenous drug delivery application. Current clinical drug delivery for oncology typically provides for intravenous administration without an awareness of achieved plasma concentration, yet interpatient variability produces consequences ranging from toxicity to ineffectual treatments. We report a closed-loop injection system integrating a pulse-photoplethysmograph to measure the concentration of an injected agent in the circulating blood system using a previously described technique. Read More

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November 2018

Comparison of Effects of Light Anesthetics, Diethyl Ether and Carbon Dioxide, on Hypothalamic Paraventricular Nucleus D and D Dopamine Receptors- and Glucosensitive Neurons-Induced Food Intake in Fasted Conscious Rats.

Basic Clin Neurosci 2018 Jul-Aug;9(4):269-274. Epub 2018 Jul 1.

Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Carbon Dioxide (CO) and diethyl ether are used as light anesthetics. However, experimental data about their side effects are scarce. In addition, in all our previous works on regulatory mechanisms of hypothalamus during food intake, including the effect of Paraventricular Nucleus (PVN) D and D dopamine receptors and glucosensitive neurons, the drug injections were performed under brief diethyl ether anesthesia. Read More

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Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats.

Evid Based Complement Alternat Med 2018 1;2018:3239785. Epub 2018 Nov 1.

School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, China.

Yin Chen Hao Tang (YCHT) is one of the most famous hepatoprotective herbal formulas in China, but its pharmacokinetic investigation in model rats has been rarely conducted. In this study, the hepatic injury model was caused by intraperitoneal injections of carbon tetrachloride (CCl), and YCHT was orally administered to the model and normal rats. An ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established to analyze the plasma pharmacokinetics of eight major bioactive ingredients from YCHT in both the normal and liver injured rats. Read More

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November 2018

Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman.

Case Rep Dermatol 2018 Sep-Dec;10(3):247-250. Epub 2018 Nov 14.

Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. Read More

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November 2018
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Cost effectiveness of ixekizumab versus secukinumab in the treatment of moderate-to-severe plaque psoriasis in Spain.

Clinicoecon Outcomes Res 2018 12;10:747-759. Epub 2018 Nov 12.

Global Patient Outcomes and Real World Evidence International, Eli Lilly, Surrey, UK.

Background: Currently, several biologic agents are available for the treatment of moderate-to-severe plaque psoriasis, including newer agents with similar mechanisms of action and efficacy; therefore, there is a need to evaluate their efficiency in terms of cost effectiveness.

Objective: This study evaluates the cost effectiveness of recently approved interleukin (IL)-17A antagonists, ixekizumab and secukinumab, for the treatment of moderate-to-severe plaque psoriasis from the perspective of the Spanish National Health System (NHS).

Materials And Methods: A Markov model with a lifetime horizon was developed to compare the cost effectiveness of ixekizumab vs. Read More

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November 2018

Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin.

Int J Nanomedicine 2018 9;13:7319-7331. Epub 2018 Nov 9.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China,

Background: Non-injectable delivery of peptides and proteins are not feasible due to its large molecular, high hydrophilic and gastrointestinal degradation. Therefore, proposing a new method to solve this problem is a burning issue.

Purpose: The objective of this study was to propose a novel protein delivery strategy to vanquish the poor efficacy of buccal mucosa delivery systems for protein delivery and then investigate the detailed mechanisms of the enhanced buccal delivery of protein, using insulin as a model drug. Read More

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November 2018

Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia.

Sci Rep 2018 Dec 5;8(1):17668. Epub 2018 Dec 5.

Department of Pediatric General and Thoracic Surgery, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development via modulation of vSMC phenotype from undifferentiated, proliferative phenotype to differentiated, contractile phenotype. Read More

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December 2018

CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism Department of Medicine, and.

We describe a protective effect on autoimmune diabetes and reduced destructive insulitis in NOD.scid recipients following splenocyte injections from diabetic NOD donors and sorted CD19+ cells compared with NOD.scid recipients receiving splenocytes alone. Read More

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December 2018

Transamniotic stem cell therapy (TRASCET) in a rabbit model of spina bifida.

J Pediatr Surg 2018 Nov 5. Epub 2018 Nov 5.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Purpose: Transamniotic stem cell therapy (TRASCET) with select mesenchymal stem cells (MSCs) has been shown to induce partial or complete skin coverage of spina bifida in rodents. Clinical translation of this emerging therapy hinges on its efficacy in larger animal models. We sought to study TRASCET in a model requiring intra-amniotic injections 60 times larger than those performed in the rat. Read More

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November 2018

[Paraffin oil injecions due to bigorexia may cause hypercalcaemia].

Ugeskr Laeger 2018 Nov;180(48)

Paraffin oil injections may cause severe hypercalcaemia, likely due to development of granulomas at injection sites, activating 1,25 dihydroxyvitamin D and increasing calcium uptake from gut, kidney and bone. This is a case report of a 39-year-old male with severe hypercalcaemia and renal failure due to paraffin oil injections. He was treated with prednisolone (25-50 mg daily), but the disease recurred the next two summers probably due to erroneous vitamin D supplement and sun exposure. Read More

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November 2018
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Practice of emergency obstetric care signal functions and reasons for non-provision among health centers and hospitals in Lake and Western zones of Tanzania.

BMC Health Serv Res 2018 Dec 5;18(1):944. Epub 2018 Dec 5.

National Institute for Medical Research (NIMR)-Headquarters, PO Box 9356, Dar-es-Salaam, Tanzania.

Background: The Lake and Western Zones of Tanzania that encompass eight regions namely; Kagera, Geita, Simiyu, Shinyanga, Mwanza, Mara Tabora and Kigoma have consistently been reported with the poorest Maternal Newborn and Child Health (MNCH) indicators in the country. This study sought to establish the provision of Emergency Obstetric Care (EmOC) signal functions and reasons for the failure to do so among health centers and hospitals in the two zones.

Methods: All the 261 public and private hospitals and health centers providing Obstetric Care services in Lake and Western Zones were surveyed in 2014. Read More

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December 2018
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Rétinopathie diabétique.

Rev Prat 2016 Nov;67(9):1001-1008

Service d'ophtalmologie du Nouvel Hôpital civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.

Diabetic retinopathy. Diabetic retinopathy (DR) is a disease whose screening actually can change the functional prognosis for the patients. It makes blindness avoidable. Read More

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November 2016

Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis.

J Ethnopharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon. Electronic address:

Ethnopharmacological Relevance: Ulmus macrocarpa Hance (UMH), of the family Ulmaceae, is a deciduous tree, widely distributed throughout Korea. UMH has been used as a traditional oriental medicine in Korea for the treatment of urological disorders, including bladder outlet obstrulmition (BOO), lower urinary tract syndrome (LUTS), diuresis, and hematuria. To date, its possible protective effects against benign prostatic hyperplasia (BPH) have not been analyzed. Read More

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November 2018

Joint and soft-tissue injections in rehabilitation inpatients taking direct oral anticoagulants.

Int J Rehabil Res 2018 Nov 30. Epub 2018 Nov 30.

Providence Healthcare.

The risk for complications associated with joint and soft-tissue injections in patients taking direct oral anticoagulants (DOACs) is not fully understood. In this retrospective evaluation of 445 inpatients in a rehabilitation hospital who received corticosteroid injections, complications were compared in patients on DOACs with those who were not. After a review of all injections, no adverse events of significant bleeding (intra-articular or extra-articular) were observed. Read More

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November 2018

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia.

Glia 2018 Dec 2. Epub 2018 Dec 2.

PROTECT, Inserm U1141, Université Paris Diderot, Paris, France.

Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the developing brain. While the oxytocin system was also found to be impaired following adverse perinatal events, its role in the modulation of neuroinflammation in the developing brain is still unknown. Read More

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December 2018
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Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain.

Eur J Pain 2018 Dec 2. Epub 2018 Dec 2.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393, Porto, Portugal.

Background: Amylin is a calcitonin gene-related peptide family member expressed by nociceptors. Amylin's expression is down-regulated following nerve damage and studies suggested it affects nociception. We aimed at clarifying amylin's effects on chronic neuropathic pain and investigating its site of action. Read More

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December 2018

Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, United States.

Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More

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December 2018

Penicillin Trunk Injection Affects Bacterial Community Structure in Citrus Trees.

Microb Ecol 2018 Dec 1. Epub 2018 Dec 1.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

Huanglongbing (HLB), caused by Candidatus Liberibacter asiaticus (CLas), an uncultured α-proteobacterium, is the most destructive disease of citrus trees worldwide. In previous studies, trunk injections of penicillin reduced CLas titers and HLB symptoms in citrus. However, antibiotic effects on the whole plant microbial community, which include effects on taxa that interact with CLas, have not yet been addressed. Read More

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December 2018
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The Impact of Excluding Patients with End-Stage Knee Disease in Intra-Articular Hyaluronic Acid Trials: A Systematic Review and Meta-Analysis.

Adv Ther 2018 Dec 1. Epub 2018 Dec 1.

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.

Introduction: The Kellgren-Lawrence (K-L) grade is the most commonly used measure of radiographic disease severity in knee osteoarthritis (OA). Studies suggest that intra-articular hyaluronic acid (IA-HA) should only be considered in cases of early stage knee OA. The purpose of this review was to determine if trials administering IA-HA in early-moderate knee OA patients demonstrated greater pain relief than studies that also included patients with end-stage disease. Read More

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December 2018
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Identification of calretinin-expressing retinal ganglion cells projecting to the mouse superior colliculus.

Cell Tissue Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology, School of Life Sciences, BK 21 Plus KNU Creative BioResearch Group, College of Natural Sciences, and Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41566, South Korea.

In mice, retinal ganglion cells (RGCs), which consist of around 30 subtypes, exclusively transmit retinal information to the relevant brain systems through parallel visual pathways. The superior colliculus (SC) receives the vast majority of this information from several RGC subtypes. The objective of the current study is to identify the types of calretinin (CR)-expressing RGCs that project to the SC in mice. Read More

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December 2018

[Opacification of hydrophilic intraocular lens after multiple injections of bevacizumab].

Ophthalmologe 2018 Nov 30. Epub 2018 Nov 30.

Augenklinik, Konventhospital der Barmherzigen Brüder Linz, Seilerstätte 2, 4021, Linz, Österreich.

In the literature various causes of opacification of hydrophilic lenses have been described. Pronounced opacity is a complication that must be taken seriously because it can lead to explantation or exchange of the intraocular lens (IOL). The calcification of hydrophilic IOLs is often made responsible for an explantation. Read More

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November 2018

A Compendium of Intralesional Therapies in Nail Disorders.

Indian Dermatol Online J 2018 Nov-Dec;9(6):373-382

Department of Dermatology and STD, VMMC and Safdarjung Hospital, New Delhi, India.

Nail unit is a complex skin appendage offering natural barrier to drug penetration by virtue of its unique anatomy. This is the reason why topical as well as oral therapies can be largely ineffective when dealing with nail diseases. Intralesional (injectable therapies) offer a practical solution in this scenario. Read More

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December 2018

Effect of Surgical-Site, Multimodal Drug Injection on Pain and Stress Biomarkers in Patients Undergoing Plate Fixation for Clavicular Fractures.

Clin Orthop Surg 2018 Dec 21;10(4):455-461. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Dankook University College of Medicine, Cheonan, Korea.

Background: Surgical-site, multimodal drug injection has recently evolved to be a safe and useful method for multimodal pain management even in patients with musculoskeletal trauma.

Methods: Fifty consecutive patients who underwent plating for mid-shaft and distal clavicular fractures were included in the study. To evaluate whether surgical-site injections (SIs) have pain management benefits, the patients were divided into two groups (SI and no-SI groups). Read More

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December 2018

Lamellar macular hole formation following intravitreal bevacizumab injection for choroidal neovascularization by age-related macular degeneration.

Oman J Ophthalmol 2018 Sep-Dec;11(3):277-279

Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

This report describes a lamellar macular hole formation subsequent to intravitreal bevacizumab injection for the treatment of choroidal neovascularization (CNV) by age-related macular degeneration. A 67-year-old woman with bilateral CNV underwent 3 monthly intravitreal bevacizumab injections in her both eyes. One month after the third bilateral injection, vision loss happened. Read More

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December 2018

A case of choroidal osteoma in a 17-year-old female.

Oman J Ophthalmol 2018 Sep-Dec;11(3):267-269

Department of Optometry, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

A 17-year female was referred for complaints of blurring and decreased vision in the right eye. The patient underwent fundus examination, optical coherence tomography and B-scan ultrasonography. A well-defined, yellow-orange colored lesion was present in the posterior pole. Read More

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December 2018

Emergence of Multi-Resistant Enteric Infection In A Paediatric Unit Of Karachi, Pakistan.

J Pak Med Assoc 2018 Dec;68(12):1848-1850

Postgraduate trainee, Department of Paediatrics, Abbasi Shaheed Hospital, Karachi Medical and Denatl College.

From June 2018, onwards, there has been an upsurge of multi-resistant enteric infections in children admitted from various catchment areas of Abbasi Shaheed Hospital (ASH). This is a serious concern as very few antibiotics are available to treat the children. Children from June 2018 to September 2018 of age groups 5. Read More

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December 2018

Subcutaneous insulin administration in infants and toddlers.

J Pak Med Assoc 2018 Dec;68(12):1840-1842

Department of Endocrinology, Bharti Hospital, Karnal, India.

Management of diabetes in infants and toddlers requires the administration of multiple subcutaneous insulin injections and frequent monitoring of blood glucose. However, there are significant unique challenges in managing insulin injections in this age group due to unpredictable eating and activity patterns, less subcutaneous fat, increased risk of hypoglycaemia, and the child's inability to communicate symptoms and comprehend the need for insulin. Insulin pumps and pen devices are preferable to insulin syringes. Read More

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December 2018
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Type 3 neovascularisation (retinal angiomatous proliferation) treated with antivascular endothelial growth factor: real-world outcomes at 24 months.

Br J Ophthalmol 2018 Dec 1. Epub 2018 Dec 1.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Aims: To compare 24 months outcomes of eyes with retinal angiomatous proliferations (RAPs) treated with antivascular endothelial growth factor (anti-VEGF) with a group of controls diagnosed with other neovascular age-related macular degeneration (nAMD) subtypes in a real-world setting.

Methods: Treatment-naïve nAMD eyes that commenced anti-VEGF between January 2006 and November 2015 were identified from a registry of nAMD treatment outcomes. Cases were defined as eyes diagnosed with RAP. Read More

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December 2018

Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.

Neuropharmacology 2018 Nov 29;146:117-127. Epub 2018 Nov 29.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Medical Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Arbutin as a natural soluble glycosylated phenol possesses a wide range of pharmacological activities including anti-inflammatory and anti-oxidant effects. The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model. Chemical kindling was induced by repetitive injections of PTZ at subconvulsive doses (36 mg/kg). Read More

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November 2018

Review of Management Options for Active-Phase Peyronie's Disease.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

Introduction: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Read More

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November 2018

Intratunical Injection of Human Adipose Tissue-Derived Stem Cells Restores Collagen III/I Ratio in a Rat Model of Chronic Peyronie's Disease.

Sex Med 2018 Nov 29. Epub 2018 Nov 29.

Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Introduction: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis.

Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD.

Methods: 27 male, 12-week-old rats were divided into 3 equal groups: sham, PD without treatment, and PD treated with hADSCs 1 month after disease induction. Read More

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November 2018

Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies.

J Pharmacol Sci 2018 Nov 20. Epub 2018 Nov 20.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology, CERFO University of Catania, Catania, Italy; Regional Pharmacovigilance Centre of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy.

Introduction: Systematic review of real-world studies about repeated dexamethasone intravitreal implant (DEXi) 0.7 mg in diabetic macular edema management, in order to identify the effective window of time occurring between injections, the critical evaluation of efficacy of the treatment, and the relative long-term safety in the real life setting.

Methods: Literature databases such as PubMed, SCOPUS, and EMBASE were used to identify reports including DEX implant injections. Read More

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November 2018