1,916 results match your criteria Inhalation Toxicology [Journal]


A review on proteomics analysis to reveal biological pathways and predictive proteins in sulfur mustard exposed patients: roles of inflammation and oxidative stress.

Inhal Toxicol 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Chemical Injuries Research Center , Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a mutagenic compound that targets various organs. Although it causes a wide range of abnormalities, cellular and molecular mechanisms of its action are not-well-understood. Oxidation of DNA, proteins, lipids, as well as depletion of cellular nicotinamide adenine dinucleotide (NAD), antioxidants and increase of intracellular calcium are the hypothesized mechanisms of its action at the acute phase of injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1558316DOI Listing

A review of the fate of inhaled α-quartz in the lungs of rats.

Authors:
Hajime Kawasaki

Inhal Toxicol 2019 Apr 18:1-10. Epub 2019 Apr 18.

a Chemical Health Science Japan Co. Ltd , Osaka , Japan.

The distribution of dust particles within the lungs and their excretion are highly associated with their pulmonary toxicity. Literature was reviewed to discern pulmonary translocation pathways for inhaled α-quartz compared to those for inhaled TiO. Accordingly, it was hypothesized α-quartz particles in the alveoli were phagocytized by alveolar macrophages but silica-containing macrophages remained in the alveoli for longer time in contrast to the rapid elimination from the alveoli seen for TiO-containing macrophages. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2019.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2019.1597218DOI Listing
April 2019
2 Reads

Exploring the science, safety, and benefits of air care products: perspectives from the inaugural air care summit.

Inhal Toxicol 2019 Apr 18:1-13. Epub 2019 Apr 18.

q Drug and Poison Information Center , Cincinnati Children's Hospital , Cincinnati , OH , USA.

Seventy-one percent of US households purchase air care products. Air care products span a diverse range of forms, including scented aerosol sprays, pump sprays, diffusers, gels, candles, and plug-ins. These products are used to eliminate indoor malodors and to provide pleasant scent experiences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1597221DOI Listing
April 2019
1 Read

Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress.

Inhal Toxicol 2019 Apr 15:1-15. Epub 2019 Apr 15.

a Department of Environmental Health Sciences , College of Public Health, University of Georgia , Athens , GA , USA.

Background: Wildland firefighters conducting prescribed burns are exposed to a complex mixture of pollutants, requiring an integrated measure of exposure.

Objective: We used urinary mutagenicity to assess if systemic exposure to mutagens is higher in firefighters after working at prescribed burns versus after non-burn work days. Other biomarkers of exposure and oxidative stress markers were also measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1600079DOI Listing

Correction.

Authors:

Inhal Toxicol 2019 Apr 5. Epub 2019 Apr 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1603612DOI Listing

Impact of cigarette smoking on kidney inflammation and fibrosis in diabetic rats.

Inhal Toxicol 2019 Apr 4:1-7. Epub 2019 Apr 4.

a Department of Clinical Pharmacy, Faculty of Pharmacy , Jordan University of Science and Technology , Irbid , Jordan.

Background: Cigarette smoking is a very common habit worldwide contributing to risk of kidney dysfunction and diabetes (DM). However, the mechanisms are unclear.

Aim: The goal of the present study was to assess the effects of cigarette smoking on kidney oxidative stress, inflammation, and remodeling in streptozotocin (STZ) rat model of diabetes. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2019.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2019.1597219DOI Listing
April 2019
5 Reads

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.

Inhal Toxicol 2018 Nov - Dec;30(13-14):553-567. Epub 2019 Mar 8.

a Altria Client Services LLC , Richmond , VA , USA.

We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up to 4 hours/day, 5 days/week, for 3 weeks. The 3R4F and e-vapor exposures were set to match the target nose port aerosol nicotine concentration (∼41 µg/L). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1576807DOI Listing
March 2019
2 Reads

Altered levels of GST activity, Vit C, TPX and Cu in individuals with long-term sulfur mustard-induced lung complications.

Inhal Toxicol 2018 Nov - Dec;30(13-14):483-491. Epub 2019 Mar 8.

d Immunoregulation Research Center , Shahed University , Tehran , Iran.

Context: Sulfur mustard (SM) as a cytotoxic and blistering agent can alkylate a variety of cellular components, causing the incidence of ongoing oxidative stress.

Objective: The present study was conducted to assess oxidative stress index (OSI) in SM-exposed veterans with long-term pulmonary complications.

Methods: Participants consisted of 289 SM-exposed individuals with pulmonary complications (classified into three groups: mild, moderate and severe) and 66 healthy individuals as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1545809DOI Listing
March 2019
1 Read

Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice.

Inhal Toxicol 2018 Nov - Dec;30(13-14):498-508. Epub 2019 Mar 8.

g Department of Anatomy, Biology and Medicine, Division of Morphological Analysis, Faculty of Medicine , Oita University , Oita , Japan.

Background: The aim of this study was to investigate the protein and trace element components of PM2.5 and their contribution to the allergic airway inflammation in BALB/c mice.

Methods: PM2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1561769DOI Listing
March 2019
1 Read

Robert T. Drew, Ph.D. (1936-2018).

Authors:
Dan Costa

Inhal Toxicol 2018 Nov - Dec;30(13-14):568-569. Epub 2019 Mar 8.

a Emeritus EPA, Adjunct Professor, Environmental Science and Engineering, University of North Carolina , Chapel Hill , NC , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1574967DOI Listing

Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive.

Inhal Toxicol 2018 Nov - Dec;30(13-14):542-552. Epub 2019 Mar 4.

c Exponent , Alexandria , VA , USA.

Cellulose insulation (CI), a common building material, is a mixture of cellulose fibers and borates. Borates are approximately 20% of the product weight and act as a flame retardant. Given possible exposure to workers and consumers, an inhalation toxicity study was conducted following Organization for Economic Co-operation and Development (OECD) 414 for Prenatal Development Toxicity to evaluate if CI is a developmental toxicant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1576806DOI Listing

Influence of tobacco smoke on zinc, cadmium, iron, iron-binding proteins, and low-weight anti-oxidant status in pregnancy.

Inhal Toxicol 2018 Nov - Dec;30(13-14):534-541. Epub 2019 Feb 22.

a Department of Biomedical and Environmental Analysis, Faculty of Pharmacy , Wroclaw Medical University , Wrocław , Poland.

Pregnancy and tobacco smoking (TS) each can cause increases in reactive oxygen species (ROS) production; this, in turn, can lead to disorders in iron management and disruption of the pro- and anti-oxidant balance. The aim of the study was to analyze the influence of TS and Cd on Fe, Zn, and anti-oxidant levels (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1576805DOI Listing
February 2019
1 Read

A new approach to estimate ultrafine particle respiratory deposition.

Inhal Toxicol 2019 Feb 20:1-9. Epub 2019 Feb 20.

b Department of Mechanical Engineering , California Baptist University , Riverside , CA, USA.

Ultrafine particles (UFPs) in workplaces have been and continue to be an important occupational health concern. The inhalation and the consequent deposition of UFPs in workers' lower airways can lead to many adverse health effects. Therefore, it is vital to study the deposition of UFPs in the human respiratory tract from the viewpoint of occupational health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1576808DOI Listing
February 2019
5 Reads

An inhalational swine model for the characterization of physiological effects and toxicological profile associated with cyanide poisoning.

Inhal Toxicol 2018 Nov - Dec;30(13-14):509-518. Epub 2019 Feb 13.

a Battelle Memorial Institute , Columbus , OH , USA.

Cyanides are highly toxic compounds that have been used as weapons of terrorism throughout history. Cyanide (CN) is acutely toxic by all routes of administration; however, inhalation is the main exposure route. To adequately test effective countermeasures against inhalational CN threats, robust and well-characterized animal models are needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1569181DOI Listing
February 2019
2.260 Impact Factor

Comparison of the content of tobacco alkaloids and tobacco-specific nitrosamines in 'heat-not-burn' tobacco products before and after aerosol generation.

Inhal Toxicol 2018 Nov - Dec;30(13-14):527-533. Epub 2019 Feb 11.

a Department of Industrial Plant Science & Technology , Chungbuk National University , Cheongju , Chungbuk , Republic of Korea.

Standardized methods for collecting smoke and for measuring smoke components in heat not burn tobacco product (HTP) are yet to be established, and there is a lack of consensus as to whether the content of HTP cigarettes can be assayed in the same manner as for conventional cigarettes. Since HTPcigarettes do not generate ash when smoked, we compared the levels of tobacco alkaloids (TAs) and tobacco-specific nitrosamines (TSNAs) of HTP cigarettes before and after aerosol generation. HTP cigarettes were smoked according to two international standardization methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2019.1572840DOI Listing
February 2019

Evaluation of the impact of waterpipe tobacco smoke exposure on the activity and expression of rat hepatic CYP450: a pharmacokinetic study.

Inhal Toxicol 2018 Nov - Dec;30(13-14):519-526. Epub 2019 Feb 8.

c Department of Medical Laboratory Sciences Faculty of Applied Medical Sciences , Jordan University of Science and Technology , Irbid , Jordan.

Waterpipe smoke contains many toxic constituents that can alter drug pharmacokinetics. This study assessed the effect of waterpipe smoke exposure on the activity and expression of CYP450 enzymes in rats. Animals (n = 10/group) were exposed to either waterpipe smoke or side-stream cigarette smoke for 1 h/day (6 days/week) for 31 days, or fresh air (control). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2019.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2019.1569182DOI Listing
February 2019
7 Reads

Association of single nucleotide polymorphisms in the CYBA gene with coal workers' pneumoconiosis in the Han Chinese population.

Inhal Toxicol 2018 Nov - Dec;30(13-14):492-497. Epub 2019 Jan 18.

c Department of Rheumatology and Clinical Immunology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

Coal workers' pneumoconiosis (CWP) is caused by long-term exposure to inhaled coal dust; it is likely influenced by the interaction between environmental factors and multiple susceptibility genes, such as the CYBA (cytochrome b-245α polypeptide) gene that has recently been identified to be involved in the genetic susceptibility for several pulmonary diseases. The aim of this case-control study was to explore the association between CYBA gene polymorphisms and the development of CWP in coal miners belonging to the Han ethnic group in China. Single nucleotide polymorphisms (SNPs) rs7195830, rs13306296, rs4673, rs9932581, and rs16966671 of the CYBA gene were analyzed in CWP patients (n = 652) and dust-exposed control subjects (n = 648) using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) on the Sequenom MassARRAY® platform (Sequenom, San Diego, CA, USA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1558315DOI Listing
January 2019
4 Reads

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.

Inhal Toxicol 2018 Sep - Oct;30(11-12):472-481. Epub 2019 Jan 18.

a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL) , U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.

Halogenated platinum salts can trigger the development of occupational asthma. Until recently, laboratory research into the development and manifestation of platinum hypersensitivity responses were hindered by the lack of an animal model suitable for assessing the functional consequences of allergic sensitization. We employed a newly developed mouse model to assess the potential allergenicity of ammonium tetrachloroplatinate (ATCP), compare the relative potency of ATCP and another platinum salt, ammonium hexachloroplatinate (AHCP) and assess potential cross-reactivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1554015DOI Listing
January 2019
3 Reads

Pulmonary exposure to peat smoke extracts in rats decreases expiratory time and increases left heart end systolic volume.

Inhal Toxicol 2018 Sep - Oct;30(11-12):439-447. Epub 2019 Jan 15.

a US Environmental Protection Agency, Environmental Public Health Division , Durham , NC , USA.

Exposure to wildland fire-related particulate matter (PM) causes adverse health outcomes. However, the impacts of specific biomass sources remain unclear. The purpose of this study was to investigate cardiopulmonary responses in rats following exposure to PM extracts collected from peat fire smoke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1551443DOI Listing
January 2019
2 Reads
2.260 Impact Factor

Particle and inhalation exposure in human and monkey computational airway models.

Inhal Toxicol 2018 Sep - Oct;30(11-12):416-428. Epub 2019 Jan 8.

a Department of Energy and Environmental Engineering, Faculty of Engineering Sciences , Kyushu University , Kasuga , Japan.

Regional deposition of inhaled aerosols is essential for assessing health risks from toxic exposure. Upper airway physiology plays a significant role in respiratory defense by filtering micrometer particles, whose deposition mechanism is predominantly inertial impaction and is mainly controlled by airflow characteristics. The monkey is commonly used in tests that study inhalation toxicity as well as in preclinical tests as human surrogates due to their anatomical similarities to humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1545810DOI Listing
January 2019
1 Read

Modification of nano-silver bioactivity by adsorption on carbon nanotubes and graphene oxide.

Inhal Toxicol 2018 Sep - Oct;30(11-12):429-438. Epub 2019 Jan 8.

b Department of Chemistry and Environmental Science , New Jersey Institute of Technology , Newark , NJ , USA.

Objective: The toxicity of silver nanomaterials in various forms has been extensively evaluated, but the toxicity of silver nanocarbon composites is less well understood. Therefore, silver-carbon nanotube composites (Ag-MWCNT-COOH) and silver-graphene oxide composites (Ag-GO) were synthesized by microwave irradiation and evaluated in two in vitro cell models.

Materials/methods: Toxicity of silver nanosphere (Ag), Ag-MWCNT-COOH and Ag-GO were analyzed by MTS assay and LDH assay in primary C57BL/6 murine alveolar macrophages and human THP-1 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1547334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397085PMC
January 2019
1 Read

Changes in lipid profile parameters and PON1 status associated with L55M PON1 polymorphism, overweight and exposure to tobacco smoke.

Inhal Toxicol 2018 Sep - Oct;30(11-12):463-471. Epub 2019 Jan 8.

a Department of Biomedical and Environmental Analysis, Faculty of Pharmacy with Division of Laboratory Diagnostics , Wroclaw Medical University , Wrocław , Poland.

Objective: The aim of our study was to investigate the effects of paraoxonase 1 (PON1) L55M polymorphism on the enzyme's activity and concentration in the serum as well as its association with lipid profile parameters in a group of healthy persons. We also evaluated the presence of PON1 L55M polymorphism in a group of subjects exposed to tobacco smoke and with overweight or obesity on those parameters.

Methods: Analysis of L55M polymorphism was done using polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (PCR - RFLP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1554014DOI Listing
January 2019
11 Reads

Engineered nanoparticle exposure and cardiovascular effects: the role of a neuronal-regulated pathway.

Inhal Toxicol 2018 08 3;30(9-10):335-342. Epub 2019 Jan 3.

b Department of Pharmaceutical Sciences , West Virginia University , Morgantown , WV , USA.

Human and animal studies have confirmed that inhalation of particles from ambient air or occupational settings not only causes pathophysiological changes in the respiratory system, but causes cardiovascular effects as well. At an equal mass lung burden, nanoparticles are more potent in causing systemic microvascular dysfunction than fine particles of similar composition. Thus, accumulated evidence from animal studies has led to heightened concerns about the potential short- and long-term deleterious effects of inhalation of engineered nanoparticles on the cardiovascular system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1535634DOI Listing
August 2018
1 Read

Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent.

Inhal Toxicol 2018 Sep - Oct;30(11-12):448-462. Epub 2019 Jan 2.

a Agency for Toxic Substances and Disease Registry , Atlanta , GA , USA.

Objective: Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1551444DOI Listing
January 2019
11 Reads

Enhanced cerebellar myelination with concomitant iron elevation and ultrastructural irregularities following prenatal exposure to ambient particulate matter in the mouse.

Inhal Toxicol 2018 08 20;30(9-10):381-396. Epub 2018 Dec 20.

a Department of Environmental Medicine , University of Rochester School of Medicine , Rochester , NY , USA.

Accumulating evidence indicates the developing central nervous system (CNS) is a target of air pollution toxicity. Epidemiological reports increasingly demonstrate that exposure to the particulate matter (PM) fraction of air pollution during neurodevelopment is associated with an increased risk of neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). These observations are supported by animal studies demonstrating prenatal exposure to concentrated ambient PM induces neuropathologies characteristic of ASD, including ventriculomegaly and aberrant corpus callosum (CC) myelination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1533053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400059PMC
August 2018
4 Reads

Gene expression changes in rat brain regions after 7- and 28 days inhalation exposure to exhaust emissions from 1st and 2nd generation biodiesel fuels - The FuelHealth project.

Inhal Toxicol 2018 Jun - Jul;30(7-8):299-312. Epub 2018 Dec 20.

a Division of Infection Control and Environmental Health , Norwegian Institute of Public Health , Oslo , Norway.

While the impact of emissions from combustion of fossil fuel on human health has been extensively studied, current knowledge of exhaust exposure from combustion of biofuels provides limited and inconsistent information about its neurotoxicity. The objective of the present work was to compare the gene expression patterns in rat frontal cortex and hippocampus after exposure to diesel exhaust emissions (DEE) from combustion of two 1st generation fuels, 7% fatty acid methyl esters (FAME) (B7) and 20% FAME (B20), and a 2nd generation 20% FAME/hydrotreated vegetable oil (SHB20: synthetic hydrocarbon biofuel), with and without diesel particulate filter (DPF). The Fisher 344 rats (n = 7/treatment) were exposed to DEE for 7 days (6h/day), and for 28 days (6h/day, 5 days/week) in whole body exposure chambers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1520370DOI Listing
December 2018
3 Reads

Quantum dot induced acute changes in lung mechanics are mouse strain dependent.

Inhal Toxicol 2018 Aug - Aug;30(9-10):397-403. Epub 2018 Dec 7.

a Department of Environmental and Occupational Health Sciences , University of Washington , Seattle , WA , USA.

Introduction: Concerns have been raised regarding occupational exposure to engineered nanomaterials (ENMs). Potential impacts on lung function from inhalation exposures are of concern as the lung is a sensitive ENM target in animals. Epidemiological data suggest that occupational exposure to ENMs may impact respiratory and cardiovascular health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1542046DOI Listing
December 2018
2 Reads

Source-apportioned coarse particulate matter exacerbates allergic airway responses in mice.

Inhal Toxicol 2018 Sep - Oct;30(11-12):405-415. Epub 2018 Dec 5.

b Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

Exposure to coarse particulate matter (PM) is associated with lung inflammation and exacerbation of respiratory symptoms in sensitive populations, but the degree to which specific emission sources contribute to these effects is unclear. We examined whether coarse PM samples enriched with diverse sources differentially exacerbate allergic airway responses. Coarse PM was collected weekly (7/2009-6/2010) from urban (G. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1542047DOI Listing
December 2018
13 Reads
2.260 Impact Factor

The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Aug - Aug;30(9-10):327-334. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1530316DOI Listing
December 2018
39 Reads

Toxic effects of subacute inhalation exposure to trichloroethylene on serum lipid profile, glucose and biochemical parameters in Sprague-Dawley rats.

Inhal Toxicol 2018 Aug - Aug;30(9-10):354-360. Epub 2018 Nov 27.

a Department of Occupational Health Engineering, School of Health , Shiraz University of Medical Sciences , Shiraz , Iran.

The current study evaluated the inhalation toxicity of trichloroethylene (TCE) at 0, 10, 100, 250 and 400 ppm in Sprague-Dawley rats for 10 day period, because the subacute inhalation toxicity of TCE on serum lipid profile, glucose and some biochemical parameters has not been previously reported. TCE vapors were generated using the dynamic generation system based on evaporation method in the exposure chamber. On the basis of the results, mean serum low-density lipoprotein (LDL) and albumin (ALB) decreased significantly in all the groups exposed to TCE compared with the control group (p < . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1526233DOI Listing
November 2018
11 Reads
2.260 Impact Factor

Mesenchymal stem cells overexpressing Ang1 attenuates phosgene-induced acute lung injury in rats.

Inhal Toxicol 2018 Nov 5:1-8. Epub 2018 Nov 5.

a Department of Intensive Care Unit , Center of Emergency and Intensive Care Unit, Jinshan Hospital, Fudan University , Shanghai , China.

Phosgene-induced acute lung injury (P-ALI) is characterized by inflammation and effective treatments are lacking. Angiopoietin-1 (Ang1) has the beneficial effects on P-ALI. Mesenchymal stem cells (MSCs) have the potential for re-epithelization and recovery in lung injury. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1521483DOI Listing
November 2018
14 Reads

Subchronic air pollution exposure increases highly palatable food intake, modulates caloric efficiency and induces lipoperoxidation.

Inhal Toxicol 2018 Aug - Aug;30(9-10):370-380. Epub 2018 Nov 2.

a Laboratório de Poluição Atmosférica Universidade Federal de Ciências da Saúde de Porto Alegre , Porto Alegre , Brazil.

The investigation of the relationship between air pollution and obesity has captured the interest of researchers. However, the mechanism regarding the association between air pollution exposure and metabolic diseases and obesity still remains unclear. We aimed to investigate the effects of subchronic ROFA exposure on consumption and preference for highly palatable food and its interference on biochemical, lipid and oxidative stress parameters in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1530317DOI Listing
November 2018
2 Reads

Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study.

Inhal Toxicol 2018 Nov 2:1-6. Epub 2018 Nov 2.

d Department of Medicine School of Medicine , University of Louisville , Louisville, KY , USA.

Introduction: A recent study reported levels of metal emissions in e-cigarette (EC) aerosol. Herein we present a risk assessment analysis of the published findings using total daily exposure limits.

Methods: Median and 75th percentile metal concentrations in EC aerosols were used to determine the level of daily liquid consumption (g/d) that would exceed the permissible daily exposures (PDEs) defined for inhalation medications (cadmium, chromium, copper, nickel, lead, antimony and tin). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1523262DOI Listing
November 2018
3 Reads

Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice.

Inhal Toxicol 2018 Jun - Jul;30(7-8):287-298. Epub 2018 Oct 30.

a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.

Efficacy of two oximes treatments evaluated during inhalation of sarin vapor (LCt, 755.9 mg/min/m) in simulated real scenario in vivo. Majority of mice either became moribund or died within 1-2 min during exposure to multifold-lethal concentrations of sarin vapor. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1520369DOI Listing
October 2018
3 Reads
2.260 Impact Factor

Composition and chemical health hazards of the most common electronic cigarette liquids in nine European countries.

Inhal Toxicol 2018 Aug - Aug;30(9-10):361-369. Epub 2018 Oct 29.

a Laboratory of Toxicology, Medical School , University of Crete , Heraklion , Greece.

Background: The aim of the present study was to identify the composition and reported chemical health hazards of the most common electronic cigarette liquids (e-liquids) in nine European Union (EU) Member States (MS) prior to adoption of the Tobacco Product Directive (TPD).

Materials And Methods: Within the Horizon2020, EUREST-PLUS study, 122 of the most commonly sold e-liquids in 9 EU MS were randomly selected and purchased. A quantitative and qualitative chemical analysis was performed using a previously validated based gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry method. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1527879DOI Listing
October 2018
24 Reads

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools.

Inhal Toxicol 2018 Jun - Jul;30(7-8):255-272. Epub 2018 Oct 17.

a Nano Safety Research Group, School of Engineering and Physical Sciences, Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University , Edinburgh , UK.

High-Temperature Insulation Wools (HTIW), such as alumino silicate wools (Refractory Ceramic Fibers) and Alkaline Earth Silicate wools, are used in high-temperature industries for thermal insulation. These materials have an amorphous glass-like structure. In some applications, exposure to high temperatures causes devitrification resulting in the formation of crystalline species including crystalline silica. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1513610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334780PMC
October 2018
2 Reads

Accounting for effects of system dynamics to improve accuracy of emissions reported in e-cig vaping machines.

Inhal Toxicol 2018 Aug - Aug;30(9-10):343-353. Epub 2018 Oct 17.

a Department of Mechanical Engineering , Rochester Institute of Technology , Rochester , NY , USA.

Laboratory emissions testing of electronic cigarettes continues to be a focus in the tobacco research community. In particular, to inform policy regarding appropriate test protocols to regulate the manufacture, marketing and sale of tobacco products. This study aims to enhance current understanding of the way laboratory systems used to generate topography profiles and capture resultant emissions from inhaled tobacco products may interact with the device under test. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1526232DOI Listing
October 2018
7 Reads

Burnt sugarcane harvesting work: effects on pulmonary and systemic inflammatory markers.

Inhal Toxicol 2018 Oct 17:1-8. Epub 2018 Oct 17.

f Divisão de Pneumologia , Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil .

Objective: To evaluate the effects of burnt sugarcane harvesting on the plasmatic and urinary concentrations of the club cell secretory protein (CC16) and inflammatory systemic biomarkers in a group of sugarcane cutters.

Methods: Seventy-eight sugar cane workers were evaluated. The plasmatic and urinary concentrations of CC16, a pulmonary damage marker and inflammatory systemic biomarkers were collected at three time points: before, three months after and six months after the onset of the burnt sugarcane harvesting period. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1494765DOI Listing
October 2018
25 Reads

Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms.

Inhal Toxicol 2018 Oct 4:1-14. Epub 2018 Oct 4.

a National Institute for Public Health and the Environment , Bilthoven , The Netherlands.

Considerable differences in pulmonary responses have been observed in animals exposed to cerium dioxide nanoparticles via inhalation. These differences in pulmonary toxicity might be explained by differences in lung deposition, species susceptibility or physicochemical characteristics of the tested cerium dioxide nanoforms (i.e. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1516834DOI Listing
October 2018
11 Reads
2.260 Impact Factor

Assessment of cyclohexanone toxicity in inhalation-exposed F344 rats and B6C3F1 mice: applications in occupational health.

Inhal Toxicol 2018 Jun - Jul;30(7-8):247-254. Epub 2018 Sep 28.

a Inhalation Toxicity Study Center, Korea Occupational Safety and Health Agency , Occupational Safety and Health Research Institute , Daejeon , Korea.

Background: Cyclohexanone is a chemical used in various industries and many workers are exposed to it. Therefore, in this study, we determined the toxicity of cyclohexanone in inhalation-exposed F344 rats and B6C3F1 mice, so as to apply the findings in hazard and risk assessments.

Methods: Ten male and 10 female rats and mice per test group were exposed to cyclohexanone vapors at 0, 100, 250, and 625 ppm concentrations for 6 h per day, 5 d per week, and for 13 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1512689DOI Listing
September 2018
1 Read
2.260 Impact Factor

Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute lung injury via inhibition of NLRP3 inflammasome activation.

Inhal Toxicol 2018 Mar - Apr;30(4-5):187-194

a Center of Emergency & Intensive Care Unit, Jinshan Hospital , Fudan University , Shanghai , China.

Objective: Angiopoietin-1 (Ang1) is reported to have the ability to attenuate endothelial permeability and inflammation during the stress condition and is considered to play a critical role in vascular stabilization. The aim of this study was to investigate the mechanisms involved in the protective effects of adenovirus-delivered Ang1 in phosgene-induced acute lung injury (ALI).

Methods: ALI was induced in rats by phosgene exposure at 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1492648DOI Listing
March 2019
4 Reads

Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population.

Inhal Toxicol 2018 05 26;30(6):213-217. Epub 2018 Sep 26.

a Department of Respiratory Medicine , Shenzhen Luohu People's Hospital, The Third Affiliatied Hospital of Shenzhen University , Shenzhen , Guangdong , China.

Background: Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of pneumoconiosis, a meta-analysis was performed in Chinese population.

Methods: We searched the related literature in PubMed and Chinese databases through June 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1494766DOI Listing
May 2018
5 Reads

Exposure to tobacco smoke increases bone loss in spontaneously hypertensive rats.

Inhal Toxicol 2018 05 26;30(6):229-238. Epub 2018 Sep 26.

a Department of Endocrinology , First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.

Purpose: To define if exposure to tobacco smoke (TS) could induce reduction of bone mass and impairment of bone architecture, features observed in osteoporosis in normotensive rats and the influence of TS exposure on the osteoporotic features exhibited in the spontaneously hypertensive (SH) rats.

Methods: Normotensive Wistar Kyoto (WKY) and SH rats were exposed to filtered air or TS for 8 weeks, then their proximal femurs were extracted for micro-computed tomography (micro-CT) assessment, histological and immune-histological examinations to quantify the adverse influence of TS exposure on the bone mass and density, as well as bone architecture.

Results: We found that TS exposure not only induced significant decreases in bone mineral density (BMD), bone volume (BV), cortical and trabecular thickness (Ct. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1506838DOI Listing
May 2018
18 Reads

Plasma and saliva levels of three metals in waterpipe smokers: a case control study.

Inhal Toxicol 2018 Sep 26:1-5. Epub 2018 Sep 26.

g Department of Psychology , Center for the Study of Tobacco Products, Virginia Commonwealth University , Richmond , VA , USA.

In this case-control study, the influence of waterpipe tobacco smoking on the plasma and saliva levels of cadmium, lead and zinc was examined in participants who were waterpipe tobacco smokers (WS) or never-smokers (NS). The concentration of metals was higher in WS relative to NS. The mean (SEM) cadmium concentration in plasma was 3. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
Publisher Site
http://dx.doi.org/10.1080/08958378.2018.1500663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435438PMC
September 2018
16 Reads

Physical characterization of the aerosol of an electronic cigarette: impact of refill liquids.

Inhal Toxicol 2018 Sep 26:1-6. Epub 2018 Sep 26.

b Department of Critical Care and Pulmonary Services, "Evangelismos" Hospital, Athens Medical School , University of Athens , Athens , Greece.

Electronic cigarettes are used to evaporate a mixture of solvents, nicotine and flavors. Liquid particles can be generated under these conditions due to evaporation/condensation. The objective of this work is to measure the physical characteristics of the aerosol emission of an e-cigarette using different refill liquids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1500662DOI Listing
September 2018
1 Read

The severity of lung injury and metabolic disorders induced by ambient PM exposure is associated with cumulative dose.

Inhal Toxicol 2018 Sep 24:1-8. Epub 2018 Sep 24.

a Department of Environmental Health School of Public Health and the Key Laboratory of Public Health Safety Ministry of Education , Fudan University , Shanghai , China.

Lots of epidemiological and experimental studies have found that ambient fine particulate matter (PM) exposure is associated with the development of cardiopulmonary diseases, obesity and diabetes. This study focused on the effects of cumulative PM exposure on pulmonary and systemic inflammation and insulin resistance. Thirty-two 6-week-old male Balb/c mice were randomly divided into four groups (FA, PM, WEEK and DAY groups) and were continuously or intermittently exposed to concentrated PM or filtered air (FA) for four weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS"). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1508258DOI Listing
September 2018
9 Reads
2.260 Impact Factor

Development of a hydrogen cyanide inhalation exposure system and determination of the inhaled median lethal dose in the swine model.

Inhal Toxicol 2018 Mar - Apr;30(4-5):195-202. Epub 2018 Sep 10.

a Battelle Biomedical Research Center , Columbus , OH , USA.

Objective: Cyanide is a highly toxic chemical, and acute exposure depletes cells and tissue of oxygen, depressing the respiratory, cardiovascular and neurological systems and potentially leading to death. Cyanide has been used as a weapon since ancient Rome and continues to pose a potential threat today. A well-characterized animal model is necessary for the development of novel methods of rapid detection and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1494764DOI Listing
March 2019
3 Reads

Corrigendum.

Authors:

Inhal Toxicol 2018 Mar - Apr;30(4-5):203. Epub 2018 Sep 7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1496586DOI Listing
September 2018
1 Read

A new cell culture exposure system for studying the toxicity of volatile chemicals at the air-liquid interface.

Inhal Toxicol 2018 Mar - Apr;30(4-5):169-177. Epub 2018 Aug 8.

a NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.

A cell culture exposure system (CCES) was developed to expose cells established at an air-liquid interface (ALI) to volatile chemicals. We characterized the CCES by exposing indigo dye-impregnated filter inserts inside culture wells to 125 ppb ozone (O) for 1 h at flow rates of 5 and 25 mL/min/well; the reaction of O with an indigo dye produces a fluorescent product. A 5-fold increase in fluorescence at 25 mL/min/well versus 5 mL/min/well was observed, suggesting higher flows were more effective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1483983DOI Listing
March 2019
2 Reads

Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats.

Inhal Toxicol 2018 Mar - Apr;30(4-5):178-186. Epub 2018 Jun 27.

a Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Cardiopulmonary and Immunology Branch, Office of Research and Development , US Environmental Protection Agency , Research Triangle Park , NC , USA.

Apelin has cardiopulmonary protective properties that promote vasodilation and maintenance of the endothelial barrier. While reductions in apelin have been identified as a contributor to various lung diseases, including pulmonary edema, its role in the effect of air pollutants has not been examined. Thus, in the current study, we sought to investigate if apelin is a downstream target of inhaled ozone and if such change in expression is related to altered DNA methylation in the lung. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08958378.2018.1483984DOI Listing
March 2019
1 Read