1,903 results match your criteria Inhalation Toxicology [Journal]


An inhalational swine model for the characterization of physiological effects and toxicological profile associated with cyanide poisoning.

Inhal Toxicol 2019 Feb 13:1-10. Epub 2019 Feb 13.

a Battelle Memorial Institute , Columbus , OH , USA.

Cyanides are highly toxic compounds that have been used as weapons of terrorism throughout history. Cyanide (CN) is acutely toxic by all routes of administration; however, inhalation is the main exposure route. To adequately test effective countermeasures against inhalational CN threats, robust and well-characterized animal models are needed. Read More

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http://dx.doi.org/10.1080/08958378.2019.1569181DOI Listing
February 2019

Comparison of the content of tobacco alkaloids and tobacco-specific nitrosamines in 'heat-not-burn' tobacco products before and after aerosol generation.

Inhal Toxicol 2019 Feb 11:1-7. Epub 2019 Feb 11.

a Department of Industrial Plant Science & Technology , Chungbuk National University , Cheongju , Chungbuk , Republic of Korea.

Standardized methods for collecting smoke and for measuring smoke components in heat not burn tobacco product (HTP) are yet to be established, and there is a lack of consensus as to whether the content of HTP cigarettes can be assayed in the same manner as for conventional cigarettes. Since HTPcigarettes do not generate ash when smoked, we compared the levels of tobacco alkaloids (TAs) and tobacco-specific nitrosamines (TSNAs) of HTP cigarettes before and after aerosol generation. HTP cigarettes were smoked according to two international standardization methods. Read More

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http://dx.doi.org/10.1080/08958378.2019.1572840DOI Listing
February 2019

Evaluation of the impact of waterpipe tobacco smoke exposure on the activity and expression of rat hepatic CYP450: a pharmacokinetic study.

Inhal Toxicol 2019 Feb 8:1-8. Epub 2019 Feb 8.

c Department of Medical Laboratory Sciences Faculty of Applied Medical Sciences , Jordan University of Science and Technology , Irbid , Jordan.

Waterpipe smoke contains many toxic constituents that can alter drug pharmacokinetics. This study assessed the effect of waterpipe smoke exposure on the activity and expression of CYP450 enzymes in rats. Animals (n = 10/group) were exposed to either waterpipe smoke or side-stream cigarette smoke for 1 h/day (6 days/week) for 31 days, or fresh air (control). Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2019.1
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http://dx.doi.org/10.1080/08958378.2019.1569182DOI Listing
February 2019
2 Reads

Association of single nucleotide polymorphisms in the CYBA gene with coal workers' pneumoconiosis in the Han Chinese population.

Inhal Toxicol 2019 Jan 18:1-6. Epub 2019 Jan 18.

c Department of Rheumatology and Clinical Immunology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

Coal workers' pneumoconiosis (CWP) is caused by long-term exposure to inhaled coal dust; it is likely influenced by the interaction between environmental factors and multiple susceptibility genes, such as the CYBA (cytochrome b-245α polypeptide) gene that has recently been identified to be involved in the genetic susceptibility for several pulmonary diseases. The aim of this case-control study was to explore the association between CYBA gene polymorphisms and the development of CWP in coal miners belonging to the Han ethnic group in China. Single nucleotide polymorphisms (SNPs) rs7195830, rs13306296, rs4673, rs9932581, and rs16966671 of the CYBA gene were analyzed in CWP patients (n = 652) and dust-exposed control subjects (n = 648) using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) on the Sequenom MassARRAY® platform (Sequenom, San Diego, CA, USA). Read More

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http://dx.doi.org/10.1080/08958378.2018.1558315DOI Listing
January 2019
1 Read

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.

Inhal Toxicol 2019 Jan 18:1-10. Epub 2019 Jan 18.

a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL) , U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.

Halogenated platinum salts can trigger the development of occupational asthma. Until recently, laboratory research into the development and manifestation of platinum hypersensitivity responses were hindered by the lack of an animal model suitable for assessing the functional consequences of allergic sensitization. We employed a newly developed mouse model to assess the potential allergenicity of ammonium tetrachloroplatinate (ATCP), compare the relative potency of ATCP and another platinum salt, ammonium hexachloroplatinate (AHCP) and assess potential cross-reactivity. Read More

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http://dx.doi.org/10.1080/08958378.2018.1554015DOI Listing
January 2019
2 Reads

Pulmonary exposure to peat smoke extracts in rats decreases expiratory time and increases left heart end systolic volume.

Inhal Toxicol 2019 Jan 15:1-9. Epub 2019 Jan 15.

a US Environmental Protection Agency, Environmental Public Health Division , Durham , NC , USA.

Exposure to wildland fire-related particulate matter (PM) causes adverse health outcomes. However, the impacts of specific biomass sources remain unclear. The purpose of this study was to investigate cardiopulmonary responses in rats following exposure to PM extracts collected from peat fire smoke. Read More

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http://dx.doi.org/10.1080/08958378.2018.1551443DOI Listing
January 2019
2.260 Impact Factor

Particle and inhalation exposure in human and monkey computational airway models.

Inhal Toxicol 2019 Jan 8:1-13. Epub 2019 Jan 8.

a Department of Energy and Environmental Engineering, Faculty of Engineering Sciences , Kyushu University , Kasuga , Japan.

Regional deposition of inhaled aerosols is essential for assessing health risks from toxic exposure. Upper airway physiology plays a significant role in respiratory defense by filtering micrometer particles, whose deposition mechanism is predominantly inertial impaction and is mainly controlled by airflow characteristics. The monkey is commonly used in tests that study inhalation toxicity as well as in preclinical tests as human surrogates due to their anatomical similarities to humans. Read More

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http://dx.doi.org/10.1080/08958378.2018.1545810DOI Listing
January 2019

Modification of nano-silver bioactivity by adsorption on carbon nanotubes and graphene oxide.

Inhal Toxicol 2019 Jan 8:1-10. Epub 2019 Jan 8.

b Department of Chemistry and Environmental Science , New Jersey Institute of Technology , Newark , NJ , USA.

Objective: The toxicity of silver nanomaterials in various forms has been extensively evaluated, but the toxicity of silver nanocarbon composites is less well understood. Therefore, silver-carbon nanotube composites (Ag-MWCNT-COOH) and silver-graphene oxide composites (Ag-GO) were synthesized by microwave irradiation and evaluated in two in vitro cell models.

Materials/methods: Toxicity of silver nanosphere (Ag), Ag-MWCNT-COOH and Ag-GO were analyzed by MTS assay and LDH assay in primary C57BL/6 murine alveolar macrophages and human THP-1 cells. Read More

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http://dx.doi.org/10.1080/08958378.2018.1547334DOI Listing
January 2019

Changes in lipid profile parameters and PON1 status associated with L55M PON1 polymorphism, overweight and exposure to tobacco smoke.

Inhal Toxicol 2019 Jan 8:1-9. Epub 2019 Jan 8.

a Department of Biomedical and Environmental Analysis, Faculty of Pharmacy with Division of Laboratory Diagnostics , Wroclaw Medical University , Wrocław , Poland.

Objective: The aim of our study was to investigate the effects of paraoxonase 1 (PON1) L55M polymorphism on the enzyme's activity and concentration in the serum as well as its association with lipid profile parameters in a group of healthy persons. We also evaluated the presence of PON1 L55M polymorphism in a group of subjects exposed to tobacco smoke and with overweight or obesity on those parameters.

Methods: Analysis of L55M polymorphism was done using polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (PCR - RFLP). Read More

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http://dx.doi.org/10.1080/08958378.2018.1554014DOI Listing
January 2019
5 Reads

Engineered nanoparticle exposure and cardiovascular effects: the role of a neuronal-regulated pathway.

Inhal Toxicol 2018 Aug - Aug;30(9-10):335-342. Epub 2019 Jan 3.

b Department of Pharmaceutical Sciences , West Virginia University , Morgantown , WV , USA.

Human and animal studies have confirmed that inhalation of particles from ambient air or occupational settings not only causes pathophysiological changes in the respiratory system, but causes cardiovascular effects as well. At an equal mass lung burden, nanoparticles are more potent in causing systemic microvascular dysfunction than fine particles of similar composition. Thus, accumulated evidence from animal studies has led to heightened concerns about the potential short- and long-term deleterious effects of inhalation of engineered nanoparticles on the cardiovascular system. Read More

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http://dx.doi.org/10.1080/08958378.2018.1535634DOI Listing
January 2019

Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent.

Inhal Toxicol 2019 Jan 2:1-15. Epub 2019 Jan 2.

a Agency for Toxic Substances and Disease Registry , Atlanta , GA , USA.

Objective: Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1551444DOI Listing
January 2019
5 Reads

Enhanced cerebellar myelination with concomitant iron elevation and ultrastructural irregularities following prenatal exposure to ambient particulate matter in the mouse.

Inhal Toxicol 2018 Aug - Aug;30(9-10):381-396. Epub 2018 Dec 20.

a Department of Environmental Medicine , University of Rochester School of Medicine , Rochester , NY , USA.

Accumulating evidence indicates the developing central nervous system (CNS) is a target of air pollution toxicity. Epidemiological reports increasingly demonstrate that exposure to the particulate matter (PM) fraction of air pollution during neurodevelopment is associated with an increased risk of neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). These observations are supported by animal studies demonstrating prenatal exposure to concentrated ambient PM induces neuropathologies characteristic of ASD, including ventriculomegaly and aberrant corpus callosum (CC) myelination. Read More

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http://dx.doi.org/10.1080/08958378.2018.1533053DOI Listing
December 2018
2 Reads

Gene expression changes in rat brain regions after 7- and 28 days inhalation exposure to exhaust emissions from 1st and 2nd generation biodiesel fuels - The FuelHealth project.

Inhal Toxicol 2018 Jun - Jul;30(7-8):299-312. Epub 2018 Dec 20.

a Division of Infection Control and Environmental Health , Norwegian Institute of Public Health , Oslo , Norway.

While the impact of emissions from combustion of fossil fuel on human health has been extensively studied, current knowledge of exhaust exposure from combustion of biofuels provides limited and inconsistent information about its neurotoxicity. The objective of the present work was to compare the gene expression patterns in rat frontal cortex and hippocampus after exposure to diesel exhaust emissions (DEE) from combustion of two 1st generation fuels, 7% fatty acid methyl esters (FAME) (B7) and 20% FAME (B20), and a 2nd generation 20% FAME/hydrotreated vegetable oil (SHB20: synthetic hydrocarbon biofuel), with and without diesel particulate filter (DPF). The Fisher 344 rats (n = 7/treatment) were exposed to DEE for 7 days (6h/day), and for 28 days (6h/day, 5 days/week) in whole body exposure chambers. Read More

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http://dx.doi.org/10.1080/08958378.2018.1520370DOI Listing
December 2018
1 Read

Quantum dot induced acute changes in lung mechanics are mouse strain dependent.

Inhal Toxicol 2018 Aug - Aug;30(9-10):397-403. Epub 2018 Dec 7.

a Department of Environmental and Occupational Health Sciences , University of Washington , Seattle , WA , USA.

Introduction: Concerns have been raised regarding occupational exposure to engineered nanomaterials (ENMs). Potential impacts on lung function from inhalation exposures are of concern as the lung is a sensitive ENM target in animals. Epidemiological data suggest that occupational exposure to ENMs may impact respiratory and cardiovascular health. Read More

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http://dx.doi.org/10.1080/08958378.2018.1542046DOI Listing
December 2018

Source-apportioned coarse particulate matter exacerbates allergic airway responses in mice.

Inhal Toxicol 2018 Dec 5:1-11. Epub 2018 Dec 5.

b Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

Exposure to coarse particulate matter (PM) is associated with lung inflammation and exacerbation of respiratory symptoms in sensitive populations, but the degree to which specific emission sources contribute to these effects is unclear. We examined whether coarse PM samples enriched with diverse sources differentially exacerbate allergic airway responses. Coarse PM was collected weekly (7/2009-6/2010) from urban (G. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1542047DOI Listing
December 2018
7 Reads
2.260 Impact Factor

The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Aug - Aug;30(9-10):327-334. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1530316DOI Listing
December 2018
29 Reads

Toxic effects of subacute inhalation exposure to trichloroethylene on serum lipid profile, glucose and biochemical parameters in Sprague-Dawley rats.

Inhal Toxicol 2018 Aug - Aug;30(9-10):354-360. Epub 2018 Nov 27.

a Department of Occupational Health Engineering, School of Health , Shiraz University of Medical Sciences , Shiraz , Iran.

The current study evaluated the inhalation toxicity of trichloroethylene (TCE) at 0, 10, 100, 250 and 400 ppm in Sprague-Dawley rats for 10 day period, because the subacute inhalation toxicity of TCE on serum lipid profile, glucose and some biochemical parameters has not been previously reported. TCE vapors were generated using the dynamic generation system based on evaporation method in the exposure chamber. On the basis of the results, mean serum low-density lipoprotein (LDL) and albumin (ALB) decreased significantly in all the groups exposed to TCE compared with the control group (p < . Read More

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http://dx.doi.org/10.1080/08958378.2018.1526233DOI Listing
November 2018
5 Reads
2.260 Impact Factor

Mesenchymal stem cells overexpressing Ang1 attenuates phosgene-induced acute lung injury in rats.

Inhal Toxicol 2018 Nov 5:1-8. Epub 2018 Nov 5.

a Department of Intensive Care Unit , Center of Emergency and Intensive Care Unit, Jinshan Hospital, Fudan University , Shanghai , China.

Phosgene-induced acute lung injury (P-ALI) is characterized by inflammation and effective treatments are lacking. Angiopoietin-1 (Ang1) has the beneficial effects on P-ALI. Mesenchymal stem cells (MSCs) have the potential for re-epithelization and recovery in lung injury. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1521483DOI Listing
November 2018
7 Reads

Subchronic air pollution exposure increases highly palatable food intake, modulates caloric efficiency and induces lipoperoxidation.

Inhal Toxicol 2018 Aug - Aug;30(9-10):370-380. Epub 2018 Nov 2.

a Laboratório de Poluição Atmosférica Universidade Federal de Ciências da Saúde de Porto Alegre , Porto Alegre , Brazil.

The investigation of the relationship between air pollution and obesity has captured the interest of researchers. However, the mechanism regarding the association between air pollution exposure and metabolic diseases and obesity still remains unclear. We aimed to investigate the effects of subchronic ROFA exposure on consumption and preference for highly palatable food and its interference on biochemical, lipid and oxidative stress parameters in rats. Read More

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http://dx.doi.org/10.1080/08958378.2018.1530317DOI Listing
November 2018
1 Read

Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study.

Inhal Toxicol 2018 Nov 2:1-6. Epub 2018 Nov 2.

d Department of Medicine School of Medicine , University of Louisville , Louisville, KY , USA.

Introduction: A recent study reported levels of metal emissions in e-cigarette (EC) aerosol. Herein we present a risk assessment analysis of the published findings using total daily exposure limits.

Methods: Median and 75th percentile metal concentrations in EC aerosols were used to determine the level of daily liquid consumption (g/d) that would exceed the permissible daily exposures (PDEs) defined for inhalation medications (cadmium, chromium, copper, nickel, lead, antimony and tin). Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1523262DOI Listing
November 2018
2 Reads

Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice.

Inhal Toxicol 2018 Jun - Jul;30(7-8):287-298. Epub 2018 Oct 30.

a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.

Efficacy of two oximes treatments evaluated during inhalation of sarin vapor (LCt, 755.9 mg/min/m) in simulated real scenario in vivo. Majority of mice either became moribund or died within 1-2 min during exposure to multifold-lethal concentrations of sarin vapor. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1520369DOI Listing
October 2018
2 Reads
2.260 Impact Factor

Composition and chemical health hazards of the most common electronic cigarette liquids in nine European countries.

Inhal Toxicol 2018 Aug - Aug;30(9-10):361-369. Epub 2018 Oct 29.

a Laboratory of Toxicology, Medical School , University of Crete , Heraklion , Greece.

Background: The aim of the present study was to identify the composition and reported chemical health hazards of the most common electronic cigarette liquids (e-liquids) in nine European Union (EU) Member States (MS) prior to adoption of the Tobacco Product Directive (TPD).

Materials And Methods: Within the Horizon2020, EUREST-PLUS study, 122 of the most commonly sold e-liquids in 9 EU MS were randomly selected and purchased. A quantitative and qualitative chemical analysis was performed using a previously validated based gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry method. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1527879DOI Listing
October 2018
16 Reads

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools.

Inhal Toxicol 2018 Jun - Jul;30(7-8):255-272. Epub 2018 Oct 17.

a Nano Safety Research Group, School of Engineering and Physical Sciences, Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University , Edinburgh , UK.

High-Temperature Insulation Wools (HTIW), such as alumino silicate wools (Refractory Ceramic Fibers) and Alkaline Earth Silicate wools, are used in high-temperature industries for thermal insulation. These materials have an amorphous glass-like structure. In some applications, exposure to high temperatures causes devitrification resulting in the formation of crystalline species including crystalline silica. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1513610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334780PMC
October 2018
1 Read

Accounting for effects of system dynamics to improve accuracy of emissions reported in e-cig vaping machines.

Inhal Toxicol 2018 Aug - Aug;30(9-10):343-353. Epub 2018 Oct 17.

a Department of Mechanical Engineering , Rochester Institute of Technology , Rochester , NY , USA.

Laboratory emissions testing of electronic cigarettes continues to be a focus in the tobacco research community. In particular, to inform policy regarding appropriate test protocols to regulate the manufacture, marketing and sale of tobacco products. This study aims to enhance current understanding of the way laboratory systems used to generate topography profiles and capture resultant emissions from inhaled tobacco products may interact with the device under test. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1526232DOI Listing
October 2018
6 Reads

Burnt sugarcane harvesting work: effects on pulmonary and systemic inflammatory markers.

Inhal Toxicol 2018 Oct 17:1-8. Epub 2018 Oct 17.

f Divisão de Pneumologia , Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil .

Objective: To evaluate the effects of burnt sugarcane harvesting on the plasmatic and urinary concentrations of the club cell secretory protein (CC16) and inflammatory systemic biomarkers in a group of sugarcane cutters.

Methods: Seventy-eight sugar cane workers were evaluated. The plasmatic and urinary concentrations of CC16, a pulmonary damage marker and inflammatory systemic biomarkers were collected at three time points: before, three months after and six months after the onset of the burnt sugarcane harvesting period. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1494765DOI Listing
October 2018
11 Reads

Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms.

Inhal Toxicol 2018 Oct 4:1-14. Epub 2018 Oct 4.

a National Institute for Public Health and the Environment , Bilthoven , The Netherlands.

Considerable differences in pulmonary responses have been observed in animals exposed to cerium dioxide nanoparticles via inhalation. These differences in pulmonary toxicity might be explained by differences in lung deposition, species susceptibility or physicochemical characteristics of the tested cerium dioxide nanoforms (i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1516834DOI Listing
October 2018
8 Reads
2.260 Impact Factor

Assessment of cyclohexanone toxicity in inhalation-exposed F344 rats and B6C3F1 mice: applications in occupational health.

Inhal Toxicol 2018 Jun - Jul;30(7-8):247-254. Epub 2018 Sep 28.

a Inhalation Toxicity Study Center, Korea Occupational Safety and Health Agency , Occupational Safety and Health Research Institute , Daejeon , Korea.

Background: Cyclohexanone is a chemical used in various industries and many workers are exposed to it. Therefore, in this study, we determined the toxicity of cyclohexanone in inhalation-exposed F344 rats and B6C3F1 mice, so as to apply the findings in hazard and risk assessments.

Methods: Ten male and 10 female rats and mice per test group were exposed to cyclohexanone vapors at 0, 100, 250, and 625 ppm concentrations for 6 h per day, 5 d per week, and for 13 weeks. Read More

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http://dx.doi.org/10.1080/08958378.2018.1512689DOI Listing
September 2018
2.260 Impact Factor

Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute lung injury via inhibition of NLRP3 inflammasome activation.

Inhal Toxicol 2018 Mar - Apr;30(4-5):187-194

a Center of Emergency & Intensive Care Unit, Jinshan Hospital , Fudan University , Shanghai , China.

Objective: Angiopoietin-1 (Ang1) is reported to have the ability to attenuate endothelial permeability and inflammation during the stress condition and is considered to play a critical role in vascular stabilization. The aim of this study was to investigate the mechanisms involved in the protective effects of adenovirus-delivered Ang1 in phosgene-induced acute lung injury (ALI).

Methods: ALI was induced in rats by phosgene exposure at 8. Read More

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http://dx.doi.org/10.1080/08958378.2018.1492648DOI Listing
September 2018
1 Read

Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population.

Inhal Toxicol 2018 May 26;30(6):213-217. Epub 2018 Sep 26.

a Department of Respiratory Medicine , Shenzhen Luohu People's Hospital, The Third Affiliatied Hospital of Shenzhen University , Shenzhen , Guangdong , China.

Background: Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of pneumoconiosis, a meta-analysis was performed in Chinese population.

Methods: We searched the related literature in PubMed and Chinese databases through June 2018. Read More

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http://dx.doi.org/10.1080/08958378.2018.1494766DOI Listing
May 2018
3 Reads

Exposure to tobacco smoke increases bone loss in spontaneously hypertensive rats.

Inhal Toxicol 2018 May 26;30(6):229-238. Epub 2018 Sep 26.

a Department of Endocrinology , First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.

Purpose: To define if exposure to tobacco smoke (TS) could induce reduction of bone mass and impairment of bone architecture, features observed in osteoporosis in normotensive rats and the influence of TS exposure on the osteoporotic features exhibited in the spontaneously hypertensive (SH) rats.

Methods: Normotensive Wistar Kyoto (WKY) and SH rats were exposed to filtered air or TS for 8 weeks, then their proximal femurs were extracted for micro-computed tomography (micro-CT) assessment, histological and immune-histological examinations to quantify the adverse influence of TS exposure on the bone mass and density, as well as bone architecture.

Results: We found that TS exposure not only induced significant decreases in bone mineral density (BMD), bone volume (BV), cortical and trabecular thickness (Ct. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1506838DOI Listing
May 2018
11 Reads

Plasma and saliva levels of three metals in waterpipe smokers: a case control study.

Inhal Toxicol 2018 Sep 26:1-5. Epub 2018 Sep 26.

g Department of Psychology , Center for the Study of Tobacco Products, Virginia Commonwealth University , Richmond , VA , USA.

In this case-control study, the influence of waterpipe tobacco smoking on the plasma and saliva levels of cadmium, lead and zinc was examined in participants who were waterpipe tobacco smokers (WS) or never-smokers (NS). The concentration of metals was higher in WS relative to NS. The mean (SEM) cadmium concentration in plasma was 3. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1500663DOI Listing
September 2018
14 Reads

Physical characterization of the aerosol of an electronic cigarette: impact of refill liquids.

Inhal Toxicol 2018 Sep 26:1-6. Epub 2018 Sep 26.

b Department of Critical Care and Pulmonary Services, "Evangelismos" Hospital, Athens Medical School , University of Athens , Athens , Greece.

Electronic cigarettes are used to evaporate a mixture of solvents, nicotine and flavors. Liquid particles can be generated under these conditions due to evaporation/condensation. The objective of this work is to measure the physical characteristics of the aerosol emission of an e-cigarette using different refill liquids. Read More

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http://dx.doi.org/10.1080/08958378.2018.1500662DOI Listing
September 2018

The severity of lung injury and metabolic disorders induced by ambient PM exposure is associated with cumulative dose.

Inhal Toxicol 2018 Sep 24:1-8. Epub 2018 Sep 24.

a Department of Environmental Health School of Public Health and the Key Laboratory of Public Health Safety Ministry of Education , Fudan University , Shanghai , China.

Lots of epidemiological and experimental studies have found that ambient fine particulate matter (PM) exposure is associated with the development of cardiopulmonary diseases, obesity and diabetes. This study focused on the effects of cumulative PM exposure on pulmonary and systemic inflammation and insulin resistance. Thirty-two 6-week-old male Balb/c mice were randomly divided into four groups (FA, PM, WEEK and DAY groups) and were continuously or intermittently exposed to concentrated PM or filtered air (FA) for four weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS"). Read More

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http://dx.doi.org/10.1080/08958378.2018.1508258DOI Listing
September 2018
2 Reads
2.260 Impact Factor

Development of a hydrogen cyanide inhalation exposure system and determination of the inhaled median lethal dose in the swine model.

Inhal Toxicol 2018 Mar - Apr;30(4-5):195-202. Epub 2018 Sep 10.

a Battelle Biomedical Research Center , Columbus , OH , USA.

Objective: Cyanide is a highly toxic chemical, and acute exposure depletes cells and tissue of oxygen, depressing the respiratory, cardiovascular and neurological systems and potentially leading to death. Cyanide has been used as a weapon since ancient Rome and continues to pose a potential threat today. A well-characterized animal model is necessary for the development of novel methods of rapid detection and treatment. Read More

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http://dx.doi.org/10.1080/08958378.2018.1494764DOI Listing
September 2018
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Corrigendum.

Authors:

Inhal Toxicol 2018 Mar - Apr;30(4-5):203. Epub 2018 Sep 7.

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http://dx.doi.org/10.1080/08958378.2018.1496586DOI Listing
September 2018

A new cell culture exposure system for studying the toxicity of volatile chemicals at the air-liquid interface.

Inhal Toxicol 2018 Mar - Apr;30(4-5):169-177. Epub 2018 Aug 8.

a NHEERL , U.S. Environmental Protection Agency, Research Triangle Park , NC , USA.

A cell culture exposure system (CCES) was developed to expose cells established at an air-liquid interface (ALI) to volatile chemicals. We characterized the CCES by exposing indigo dye-impregnated filter inserts inside culture wells to 125 ppb ozone (O) for 1 h at flow rates of 5 and 25 mL/min/well; the reaction of O with an indigo dye produces a fluorescent product. A 5-fold increase in fluorescence at 25 mL/min/well versus 5 mL/min/well was observed, suggesting higher flows were more effective. Read More

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http://dx.doi.org/10.1080/08958378.2018.1483983DOI Listing
August 2018
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Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats.

Inhal Toxicol 2018 Mar - Apr;30(4-5):178-186. Epub 2018 Jun 27.

a Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Cardiopulmonary and Immunology Branch, Office of Research and Development , US Environmental Protection Agency , Research Triangle Park , NC , USA.

Apelin has cardiopulmonary protective properties that promote vasodilation and maintenance of the endothelial barrier. While reductions in apelin have been identified as a contributor to various lung diseases, including pulmonary edema, its role in the effect of air pollutants has not been examined. Thus, in the current study, we sought to investigate if apelin is a downstream target of inhaled ozone and if such change in expression is related to altered DNA methylation in the lung. Read More

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http://dx.doi.org/10.1080/08958378.2018.1483984DOI Listing

Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures.

Inhal Toxicol 2018 Mar - Apr;30(4-5):159-168. Epub 2018 Jun 22.

b Philip Morris International R&D, Philip Morris Products S.A. (part of Philip Morris International group of companies) , Neuchâtel, Switzerland.

Direct physicochemical interactions between the major components of electronic cigarette liquids (e-liquids): glycerol (VG) and propylene glycol (PG), and lung surfactant (LS) were studied by determining the dynamic surface tension under a simulated breathing cycle using drop shape method. The studies were performed for a wide range of concentrations based on estimated doses of e-liquid aerosols (up to 2500 × the expected nominal concentrations) and for various VG/PG ratios. The results are discussed as relationships among mean surface tension, surface tension amplitude, and surface rheological properties (dilatational elasticity and viscosity) versus concentration and composition of e-liquid. Read More

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http://dx.doi.org/10.1080/08958378.2018.1478916DOI Listing
June 2018
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Critical review of long-term ozone exposure and asthma development.

Inhal Toxicol 2018 02;30(3):99-113

a Gradient , Cambridge , MA , USA.

Asthma, a chronic respiratory disorder with complex etiology and various phenotypes, is a considerable public health concern in the USA and worldwide. While there is evidence suggesting ambient ozone exposure may exacerbate asthma, information regarding the potential role of ozone in asthma development is more limited. Thus, we conducted a critical review of observational epidemiology studies to determine whether long-term ambient ozone exposure is a risk factor for asthma development. Read More

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http://dx.doi.org/10.1080/08958378.2018.1455772DOI Listing
February 2018
16 Reads

Effects of nitrous acid exposure on baseline pulmonary resistance and Muc5ac in rats.

Inhal Toxicol 2018 Mar - Apr;30(4-5):149-158. Epub 2018 Jun 4.

f Department of Applied Chemistry , Graduate School of Engineering, Osaka Prefecture University , Sakai , Japan.

We examined the baseline pulmonary resistance (RLung), baseline dynamic lung compliance (Cdyn), cytokine inductions, and histological alterations in rats exposed to nitrous acid (HONO) with secondary products of nitrogen dioxide (NO) and nitric oxide (NO) to assess its biological effects. We exposed three groups of nine male F344 rats to different doses of HONO for six weeks (24 h/day). The cumulative values of HONO concentration were measured twice. Read More

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http://dx.doi.org/10.1080/08958378.2018.1476628DOI Listing
June 2018
3 Reads

Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.

Inhal Toxicol 2018 02 25;30(3):133-139. Epub 2018 May 25.

a Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine , University of Nebraska Medical Center , Omaha , NE Douglas.

Objective: Workers exposed to dusts from concentrated animal feeding operations have a high prevalence of pulmonary diseases. These exposures lead to chronic inflammation and aberrant airway remodeling. Previous work shows that activating cAMP-dependent protein kinase (PKA) enhances airway epithelial wound repair while activating protein kinase C (PKC) inhibits wound repair. Read More

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http://dx.doi.org/10.1080/08958378.2018.1474976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176920PMC
February 2018
2 Reads

Vitamin C prevents memory impairment induced by waterpipe smoke: role of oxidative stress.

Inhal Toxicol 2018 Mar - Apr;30(4-5):141-148. Epub 2018 May 22.

c Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences , Jordan University of Science and Technology , Irbid , Jordan.

Waterpipe tobacco smoking (WTS) was previously shown to be associated with memory deficits, which were related to oxidative stress. Vitamin C (VitC) has established antioxidant properties against memory deficits associated with several diseases and conditions. In this study, the potential protective effect of VitC on memory impairment induced by WTS exposure was evaluated in a rat model. Read More

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http://dx.doi.org/10.1080/08958378.2018.1474977DOI Listing
May 2018
2.260 Impact Factor

Morbidity and mortality resulting from acute inhalation exposures to hydrogen fluoride and carbonyl fluoride in rats.

Inhal Toxicol 2018 02 15;30(3):114-123. Epub 2018 May 15.

a Toxicity Evaluation Division , Army Public Health Center , Aberdeen Proving Ground , MD , USA.

Objective: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF).

Methods: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF. Respiration was monitored before, during, and after exposure. Read More

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http://dx.doi.org/10.1080/08958378.2018.1465494DOI Listing
February 2018
2 Reads

Lack of respiratory and ocular effects following acute propylene glycol exposure in healthy humans.

Inhal Toxicol 2018 02 15;30(3):124-132. Epub 2018 May 15.

b Lyondell Chemical Company , Houston , TX , USA.

Objective: Propylene glycol (PG) is a widely used solvent, chemical intermediate and carrier substance for foods, pharmaceutical and cosmetic products. Professional and occupational exposure to PG aerosol and vapor may occur from theatrical smoke generators and during application of deicing products to airplanes. While PG is considered to have low toxicity, the results of one study suggested that brief (1-min) exposure to PG mist elicited ocular and respiratory effects in humans. Read More

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http://dx.doi.org/10.1080/08958378.2018.1470207DOI Listing
February 2018

Comparative safety evaluation of riot control agents of synthetic and natural origin.

Inhal Toxicol 2018 02;30(2):89-97

a Toxicology Laboratory , Defence Research & Development Establishment , Nagpur , India.

Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecological compatibility. Read More

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http://dx.doi.org/10.1080/08958378.2018.1451575DOI Listing
February 2018
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Assessing electronic cigarette emissions: linking physico-chemical properties to product brand, e-liquid flavoring additives, operational voltage and user puffing patterns.

Inhal Toxicol 2018 02 22;30(2):78-88. Epub 2018 Mar 22.

a Department of Environmental Health , Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health , Boston , MA , USA.

Users of electronic cigarettes (e-cigs) are exposed to particles and other gaseous pollutants. However, major knowledge gaps on the physico-chemical properties of such exposures and contradictory data in published literature prohibit health risk assessment. Here, the effects of product brand, type, e-liquid flavoring additives, operational voltage, and user puffing patterns on emissions were systematically assessed using a recently developed, versatile, e-cig exposure generation platform and state-of-the-art analytical methods. Read More

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http://dx.doi.org/10.1080/08958378.2018.1450462DOI Listing
February 2018
2 Reads

Assessment of matrix metalloproteinase-8 and -9 levels in the peri-implant sulcular fluid among waterpipe (narghile) smokers and never-smokers with peri-implantitis.

Inhal Toxicol 2018 02 22;30(2):72-77. Epub 2018 Mar 22.

a Department of Prosthetic Dental Sciences, College of Dentistry , King Saud University , Riyadh , Saudi Arabia.

Objectives: It is hypothesized that levels of matrix metalloproteinase (MMP)-8 and MMP-9 are significantly higher in the peri-implant sulcular fluid (PISF) of waterpipe-smokers (WS) compared with never-smokers with peri-implantitis. The aim of the present convenience sample case-control study was to compare the levels of MMP-8 and MMP-9 in the PISF of WS and never-smokers with peri-implantitis.

Material And Methods: Individuals smoking waterpipe (Group 1) and never-smokers (Group 2) were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1449273DOI Listing
February 2018
5 Reads
2.260 Impact Factor

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure.

Inhal Toxicol 2018 02 22;30(2):49-71. Epub 2018 Mar 22.

b University of Rochester School of Medicine and Dentistry , Rochester , NY , USA.

This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e. Read More

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http://dx.doi.org/10.1080/08958378.2018.1448019DOI Listing
February 2018
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A realistic in vitro exposure revealed seasonal differences in (pro-)inflammatory effects from ambient air in Fribourg, Switzerland.

Inhal Toxicol 2018 01 6;30(1):40-48. Epub 2018 Mar 6.

a Adolphe Merkle Institute, University of Fribourg , Fribourg , Switzerland.

Ambient air pollutant levels vary widely in space and time, therefore thorough local evaluation of possible effects is needed. In vitro approaches using lung cell cultures grown at the air-liquid interface and directly exposed to ambient air can offer a reliable addition to animal experimentations and epidemiological studies. To evaluate the adverse effects of ambient air in summer and winter a multi-cellular lung model (16HBE14o-, macrophages, and dendritic cells) was exposed in a mobile cell exposure system. Read More

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http://dx.doi.org/10.1080/08958378.2018.1441926DOI Listing
January 2018
3 Reads

Tar level of cigarettes smoked and risk of smoking-related diseases.

Authors:
Peter N Lee

Inhal Toxicol 2018 01 28;30(1):5-18. Epub 2018 Feb 28.

a P.N. Lee Statistics and Computing Ltd , Sutton , Surrey , UK.

Background: Opinions differ on the relationship between tar level and risk of smoking-related disease. However, except for lung cancer, few reviews have evaluated the epidemiological evidence. Here the relationship of tar level to risk of the four main smoking-related diseases is considered. Read More

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http://dx.doi.org/10.1080/08958378.2018.1443174DOI Listing
January 2018
2 Reads