J Am Acad Orthop Surg 2021 May;29(10):e488-e496
From the Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA (Zhang, Makhni, Kang, and Blazar), and the Harvard Medical School, Boston, MA (Zhang, Makhni, Kang, and Blazar).
Amyloidosis is a disorder of misfolded proteins in human tissues, which can result in morbid cardiac and neurological disease. Historically, the utility of tissue biopsy during orthopaedic procedures to detect amyloidosis has been limited because no disease-modifying therapies were available; however, new drug therapies have recently emerged for the treatment of amyloidosis. Although these novel pharmaceuticals show promise for slowing disease progression, they are primarily effective in the early stages of amyloidosis, underscoring the importance of early diagnosis. Read More