97,570 results match your criteria Influenza

When the heart gets the flu: Fulminant influenza B myocarditis: A case-series report and review of the literature.

J Crit Care 2018 Jun 9;47:61-64. Epub 2018 Jun 9.

Département de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie (UPMC), Paris, France; Sorbonne Universités, UPMC Université Paris 06, INSERM, UMRS_1166-ICAN Institute of Cardiometabolism and Nutrition, Paris, France.

Purpose: To describe patients with refractory cardiogenic shock related to influenza B virus myocarditis rescued by venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).

Material And Methods: Consecutive patients hospitalized in our unit for influenza-associated myocarditis were prospectively included. We also conducted a systematic MEDLINE database literature review through the PubMed search engine, between 1946 and 2017. Read More

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Safety, immunogenicity and protection of A(H3N2) live attenuated influenza vaccines containing wild-type nucleoprotein in a ferret model.

Infect Genet Evol 2018 Jun 18. Epub 2018 Jun 18.

Department of Virology, Institute of Experimental Medicine, 12, acad. Pavlova street, Saint Petersburg, Russia.

Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection from influenza due to their ability to stimulate cross-reactive T cells against influenza pathogens. One of the major targets for cytotoxic T-cell immunity is viral nucleoprotein (NP), which is relatively conserved among antigenically distant influenza viruses. Nevertheless, a diversity of epitope composition has been found in the NP protein of different lineages of influenza A viruses. Read More

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National assessment of Canadian pandemic preparedness: Employing InFluNet to identify high-risk areas for inter-wave vaccine distribution.

Infect Dis Model 2017 Aug 5;2(3):341-352. Epub 2017 Jul 5.

University of Ottawa, McLaughlin Centre for Population Health Risk Assessment, 850 Peter Morand Crescent, Ottawa, Ontario, K1G 5Z3, Canada.

Background: Influenza pandemics emerge at irregular and unpredictable intervals to cause substantial health, economic and social burdens. Optimizing health-system response is vital to mitigating the consequences of future pandemics.

Methods: We developed a mathematical model to assess the preparedness of Canadian health systems to accommodate pandemic-related increases in patient demand. Read More

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August 2017
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Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes.

PLoS One 2018 21;13(6):e0199227. Epub 2018 Jun 21.

School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.

Background: A new type of influenza virus, known as type D, has recently been identified in cattle and pigs. Influenza D virus infection in cattle is typically asymptomatic; however, its infection in swine can result in clinical disease. Swine can also be infected with all other types of influenza viruses, namely A, B, and C. Read More

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Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults.

Antivir Ther 2018 Jun 21. Epub 2018 Jun 21.

Alios BioPharma, Inc., part of Janssen Pharmaceutical Companies, South San Francisco, CA, USA.

Background: This double-blind, first-in-human phase 1 study evaluated pharmacokinetics, safety and tolerability of AL-794 (prodrug of ALS-033719), a potent endonuclease inhibitor of influenza A and B in healthy volunteers.

Methods: Healthy adult volunteers were randomized to AL-794 (50-2000 mg single ascending doses, fasting) or placebo (5 cohorts, n=6:2 AL-794: placebo/cohort) in part 1, and AL-794 (50-600 mg multiple ascending doses, twice-daily, fed or fasted) or placebo (3 cohorts, n=8:2 AL-794: placebo/cohort) for 7 days in part 2. In part 3, 8 healthy volunteers from part 1 received 450 mg AL-794 (n=6) or placebo (n=2) following a high-fat meal. Read More

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Ecology and diversity in upper respiratory tract microbial population structures from a cross-sectional community swabbing study.

J Med Microbiol 2018 Jun 21. Epub 2018 Jun 21.

1​Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.

Purpose: Respiratory tract infections (RTIs) are responsible for over 2.8 million deaths per year worldwide with pathobiont carriage a required precursor to infection. We sought to determine carriage epidemiology for both bacterial and viral respiratory pathogens as part of a large population-based cross-sectional carriage study. Read More

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A naturally occurring antiviral ribonucleotide encoded by the human genome.

Nature 2018 Jun 20. Epub 2018 Jun 20.

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.

Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral life cycles is necessary for the development of new therapeutic strategies . Viperin, a member of the radical S-adenosyl-L-methionine (SAM) superfamily of enzymes, is an interferon-inducible protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus and HIV. Viperin has been suggested to elicit these broad antiviral activities through interactions with a large number of functionally unrelated host and viral proteins. Read More

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Cross-reactive mouse monoclonal antibodies raised against the hemagglutinin of A/Shanghai/1/2013 (H7N9) protect against novel H7 virus isolates in the mouse model.

Emerg Microbes Infect 2018 Jun 20;7(1):110. Epub 2018 Jun 20.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Influenza viruses remain a major global public health risk. In addition to seasonal influenza viruses, epizootic influenza A H7 subtype viruses of both the Asian and North American lineage are of concern due to their pandemic potential. In China, the simultaneous occurrence of H7N9 zoonotic episodes and seasonal influenza virus epidemics could potentially lead to novel reassortant viruses with the ability to efficiently spread among humans. Read More

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Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007-2012.

Sci Rep 2018 Jun 20;8(1):9396. Epub 2018 Jun 20.

icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.

Avian influenza viruses, including highly pathogenic strains, pose severe economic, animal and public health concerns. We implemented live bird market surveillance in Bangladesh to identify the subtypes of avian influenza A viruses in domestic waterfowl and market environments. We collected waterfowl samples monthly from 4 rural sites from 2007 to 2012 and environmental samples from 4 rural and 16 urban sites from 2009 to 2012. Read More

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[Similarity of Clinically Significant Neuropsychiatric Adverse Reactions Listed in Package Inserts between the Anti-influenza Drugs Oseltamivir and Amantadine (Possibility Attributable to Common Pharmacological Effects)].

Yakugaku Zasshi 2018 Jun 20. Epub 2018 Jun 20.

Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University.

  The anti-influenza virus drug oseltamivir has been reported to have several pharmacological actions including blocking of nicotinic acetylcholine receptor channels and activation of the dopaminergic system. These pharmacological actions highly overlap those of amantadine, another anti-influenza virus drug authorized in Japan, and ester-type local anesthetics. Moreover, oseltamivir and amantadine can clinically induce similar adverse neuropsychiatric reactions. Read More

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Prolonged evolution of virus-specific memory T cell immunity post severe avian influenza A (H7N9) virus infection.

J Virol 2018 Jun 20. Epub 2018 Jun 20.

School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China

Since 2013, influenza A/H7N9 has emerged as the commonest avian influenza subtype causing human infection, and is associated with a high fatality risk. However, the characteristics of immune memory in patients who have recovered from H7N9 infection are not well understood. We assembled a cohort of forty-five H7N9 survivors followed for up to 15 months after infection. Read More

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Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.

J Virol 2018 Jun 20. Epub 2018 Jun 20.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, China 361102

Human infection with highly pathogenic avian influenza A viruses lead to cause severe diseases and fatalities. We previously identified a potent and broad-neutralizing antibody (bnAb), 13D4, against the H5N1 virus. Here, we report the co-crystal structure of 13D4 in complex with the hemagglutinin of A/Vietnam/1194/2004 (H5N1). Read More

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Sialidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype.

J Virol 2018 Jun 20. Epub 2018 Jun 20.

Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany

Immune responses induced by currently licensed inactivated influenza vaccines are mainly directed against the hemagglutinin (HA) glycoprotein, the immunodominant antigen of influenza viruses. The resulting antigenic drift of HA requires frequent updating of the vaccine composition and annual revaccination. On the other hand, the level of antibodies directed against the neuraminidase (NA) glycoprotein, the second major influenza virus antigen, vary greatly. Read More

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Adverse event detection by integrating twitter data and VAERS.

J Biomed Semantics 2018 Jun 20;9(1):19. Epub 2018 Jun 20.

Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Vaccine has been one of the most successful public health interventions to date. However, vaccines are pharmaceutical products that carry risks so that many adverse events (AEs) are reported after receiving vaccines. Traditional adverse event reporting systems suffer from several crucial challenges including poor timeliness. Read More

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June 2018
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Comparison of response rates on invitation mode of a web-based survey on influenza vaccine adverse events among healthcare workers: a pilot study.

BMC Med Res Methodol 2018 Jun 20;18(1):59. Epub 2018 Jun 20.

Sinai Health System, Mount Sinai Hospital, Toronto, ON, Canada.

Background: Web-based surveys have become increasingly popular but response rates are low and may be prone to selection bias. How people are invited to participate may impact response rates and needs further study as previous evidence is contradictory. The purpose of this study was to determine whether response to a web-based survey of healthcare workers would be higher with a posted or an emailed invitation. Read More

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Febrile Neutropenia following Parvovirus B19 Infection and Cross Anti-Kell Reaction to E. Coli in Pregnancy.

Rev Bras Ginecol Obstet 2018 Jun 20. Epub 2018 Jun 20.

Department of Obstetrics and Gynecology, Centro Hospitalar Tâmega e Sousa, Porto, Portugal.

Parvovirus B19 has tropism for red line blood cells, causing immune hydrops during pregnancy. A positive anti-Kell Coombs reaction usually happens during pregnancy when there is production of antibodies that target Kell antigens, but cross reactions to other antigens may occur. A 24-year-old Gypsy primigravida, 0 Rhesus positive, presented with persistent isolated hyperthermia for 2 weeks and a positive indirect Coombs test result with anti-Kell antibodies at routine tests. Read More

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A survey of canine respiratory pathogens in New Zealand dogs.

N Z Vet J 2018 Jun 20:1-19. Epub 2018 Jun 20.

a School of Veterinary Science , Massey University , Palmerston North , New Zealand.

Aims: To determine which of the common canine respiratory pathogens circulate among selected populations of healthy and diseased dogs in New Zealand.

Methods: Coagulated blood samples for serology and oropharyngeal swabs for virology were collected from healthy dogs (n=47) and from dogs with acute respiratory disease (n=49). For diseased dogs a convalescent blood sample was also collected 3-4 weeks later. Read More

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Genetic basis of resistance to avian influenza in different commercial varieties of layer chickens.

Poult Sci 2018 Jun 19. Epub 2018 Jun 19.

Department of Animal Science, Iowa State University, Ames, IA 50011-3150, USA.

An outbreak of H5N2 highly pathogenic avian influenza (HPAI) in 2015, resulting in mandatory euthanization of millions of chickens, was one of the most fatal in the US history. The aim of this study was to detect genes associated with survival following natural infection with HPAI during this outbreak. Blood samples were collected from 274 individuals from 3 commercial varieties of White Leghorn. Read More

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June 2018
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The Internal Consistency and Validity of the Vaccination Attitudes Examination Scale: A Replication Study.

Ann Behav Med 2018 Jun 19. Epub 2018 Jun 19.

Division of Psychology, University of Stirling, Stirling, Scotland, UK.

Background: Vaccinations are important preventative health behaviors. The recently developed Vaccination Attitudes Examination (VAX) Scale aims to measure the reasons behind refusal/hesitancy regarding vaccinations.

Purpose: The aim of this replication study is to conduct an independent test of the newly developed VAX Scale in the UK. Read More

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Impact of European vaccination policies on seasonal influenza vaccination coverage rates: an update seven years later.

Hum Vaccin Immunother 2018 Jun 20:1-26. Epub 2018 Jun 20.

l Royal College of General Practitioners , 61 Plough Lane, Wokingham , Berkshire , RG40 1RQ , UK.

Seasonal influenza can have serious morbid consequences and can even result in death, particularly in at-risk populations, including healthcare professionals (HCPs), elderly and those living with a medical risk condition. Although in Europe recommendations exist for annual influenza vaccination in these populations in most countries, the vaccination coverage rate (VCR) is often well below the World Health Organization target of 75% coverage. In our previous survey in 2009 we showed that some elements of national vaccination policies, e. Read More

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Respiratory Infections with Particular Emphasis on Influenza Virus Activity in Persons Over 14 Years of Age in the Epidemic Season 2016/2017 in Poland.

Adv Exp Med Biol 2018 Jun 20. Epub 2018 Jun 20.

Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.

Influenza viruses cause respiratory infections every epidemic season regardless of the patient's age. The aim of this study was to determine the activity of respiratory viruses in the epidemic season 2016/2017 in Poland, with particular emphasis on influenza viruses among people aged over 14. There were 2982 clinical samples taken from patients from four age groups: 15-25, 26-44, 45-64, and ≥ 65 years tested under the Sentinel and non-Sentinel surveillance programs. Read More

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Development of Pyrosequencing Assay for Evaluation of Genetic Stability of Vaccine Strains of Live Attenuated Influenza Type B Vaccine.

Bull Exp Biol Med 2018 Jun 19. Epub 2018 Jun 19.

A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.

We developed a pyrosequencing protocol for monitoring of stability of attenuating mutations in the genome of vaccine reassortants based on master donor virus of Russian live attenuated influenza vaccine B/USSR/60/69. The developed protocol allows rapid and accurate assessment of mutations and can be used for analysis of genetic stability of reassortants during vaccine strain development and manufacturing, as well as genetic stability of vaccine isolates of influenza B virus during pre-clinical and clinical trials. Read More

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June 2018
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Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo.

Bull Exp Biol Med 2018 Jun 19. Epub 2018 Jun 19.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.

Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Read More

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Geographical and Historical Patterns in the Emergences of Novel Highly Pathogenic Avian Influenza (HPAI) H5 and H7 Viruses in Poultry.

Front Vet Sci 2018 5;5:84. Epub 2018 Jun 5.

Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium.

Over the years, the emergence of novel H5 and H7 highly pathogenic avian influenza viruses (HPAI) has been taking place through two main mechanisms: first, the conversion of a low pathogenic into a highly pathogenic virus, and second, the reassortment between different genetic segments of low and highly pathogenic viruses already in circulation. We investigated and summarized the literature on emerging HPAI H5 and H7 viruses with the aim of building a spatio-temporal database of all these recorded conversions and reassortments events. We subsequently mapped the spatio-temporal distribution of known emergence events, as well as the species and production systems that they were associated with, the aim being to establish their main characteristics. Read More

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Author Correction: New activities for old antibiotics.

Jeffrey I Cohen

Nat Microbiol 2018 Jun 19. Epub 2018 Jun 19.

Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

In the version of this News and Views originally published, the author made an incorrect reference to 'mice deficient in Mx1'. This has now been corrected so that the text instead refers to 'mice congenic for Mx1'. The full corrected sentence reads as "Pretreatment of mice congenic for Mx1, an ISG that is critical for protection of animals from influenza, with intranasal neomycin significantly improved survival; however, about 50% of the mice died. Read More

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Influenza viral vectors expressing two kinds of HA proteins for bivalent vaccines against clade and clade H5 HPAIVs.

Sci Rep 2018 Jun 19;8(1):9327. Epub 2018 Jun 19.

China Animal Health and Epidemiology Center, Qingdao, China.

The H5 highly pathogenic avian influenza viruses (HPAIVs) in China pose a serious challenge to public health and the poultry industry. In this study, we constructed a replication-competent recombinant influenza A virus of clade 2.3. Read More

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Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.

Nat Commun 2018 Jun 19;9(1):2407. Epub 2018 Jun 19.

Departments of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 422 Curie Blvd, Philadelphia, PA, 19104, USA.

Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP regulate IAV M segment splicing, but the mechanistic details were unknown. Here we show NS1-BP and hnRNP K bind M mRNA downstream of the M2 5' splice site (5'ss). Read More

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Desmoglein1 Deficiency Is a Potential Cause of Cutaneous Eruptions Induced by Shuanghuanglian Injection.

Molecules 2018 Jun 19;23(6). Epub 2018 Jun 19.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Cutaneous eruption is a common drug-adverse reaction, characterised by keratinocytes inflammation and apoptosis. Shuanghuanglian injeciton (SHLI) is a typical Chinese medicine injection, which is used to treat influenza. It has been reported that SHLI has the potential to induce cutaneous adverse eruptions. Read More

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Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.

Vaccine 2018 Jun 16. Epub 2018 Jun 16.

Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States.

Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Read More

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Agreement With Employer Influenza Vaccination Requirements Among US Healthcare Personnel During the 2016-2017 Season.

Infect Control Hosp Epidemiol 2018 Jun 20:1-3. Epub 2018 Jun 20.

4Immunization Services Division,National Center for Immunization and Respiratory Diseases,Centers for Disease Control and Prevention,Atlanta,Georgia.

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Risk Factors of Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Patients Regularly Managed by Pulmonologists.

J Med Assoc Thai 2017 Feb;100(2):142-8

Objective: The present study intended to determine the risk factors of severe exacerbation in chronic obstructive pulmonary disease patients even though managed by pulmonologists on a regular basis.

Material And Method: A retrospective case-controlled study was conducted at the chest clinic, Maharaj Nakorn Chiang Mai Hospital from 1st August 2009 to 31st July 2010. The clinical relevant data for acute exacerbation (age, sex, co-morbidity, severity of COPD, COPD medication, annual influenza vaccination, compliance with inhaled drug use, chest radiographic abnormality, and long-term oxygen therapy) were compared between severe AECOPD and stable COPD patients by logistic regression analysis. Read More

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February 2017
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Phylogenetic and molecular analysis of highly pathogenic avian influenza H5N8 and H5N5 viruses detected in Poland in 2016-2017.

Transbound Emerg Dis 2018 Jun 19. Epub 2018 Jun 19.

Department of Poultry Diseases, National Veterinary Research Institute, Pulawy, Poland.

Sixty-five poultry outbreaks and sixty-eight events in wild birds were reported during the highly pathogenic H5N8/H5N5 avian influenza epidemic in Poland in 2016-2017. The analysis of all gene segment sequences of selected strains revealed cocirculation of at least four different genome configurations (genotypes) generated through reassortment of clade 2.3. Read More

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June 2018
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Adverse events after vaccination among HIV-positive persons, 1990-2016.

PLoS One 2018 19;13(6):e0199229. Epub 2018 Jun 19.

Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

Human immunodeficiency virus (HIV) causes immune dysregulation, potentially affecting response to vaccines in infected persons. We investigated if unexpected adverse events (AEs) or unusual patterns of AEs after vaccination were reported among HIV-positive persons. We searched for domestic reports among HIV-positive persons to the Vaccine Adverse Event Reporting System (VAERS) during 1990-2016. Read More

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National surveillance and control costs for highly pathogenic avian influenza H5N1 in poultry: A benefit-cost assessment for a developing economy, Nigeria.

Res Vet Sci 2018 Jun 13;119:127-133. Epub 2018 Jun 13.

Department of Veterinary Tropical Diseases, University of Pretoria, Onderstepoort 0110, South Africa; Emergency Centre for Transboundary Animal Diseases (ECTAD), Food and Agriculture Organisation of the United Nations (FAO), Dar es Salaam, United Republic of Tanzania. Electronic address:

We conducted benefit-cost analysis of outbreak and surveillance costs for HPAI H5N1in poultry in Nigeria. Poultry's death directly cost US$ 939,734.0 due to outbreaks. Read More

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Synthesis of peptide based epsilon toxin vaccine by covalent anchoring to tetanus toxoid.

Anaerobe 2018 Jun 16. Epub 2018 Jun 16.

Gene Regulation Laboratory, National Institute of Immunology, New Delhi, 110067, India. Electronic address:

The epsilon toxin (Etx) produced by Clostridium perfringens type B and D causes severe enterotoxaemia associated with a general edema and neurological alterations, leading to subsequent death and is listed as one of the most lethal toxins. Currently employed vaccines against C. perfringens epsilon toxin include toxoid based vaccines. Read More

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June 2018
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Selective Management of Multiple Bronchopleural Fistulae in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Multidisciplinary Approach.

J Laparoendosc Adv Surg Tech A 2018 Jun 19. Epub 2018 Jun 19.

1 Section of Pediatric Surgery, Department of Surgery, Michigan Medicine , Ann Arbor, Michigan.

Introduction: This case highlights the successful utilization of a multidisciplinary approach to numerous bilateral bronchopleural fistulae (BPF) using minimally invasive techniques. In this study, we present a previously healthy 14-year-old male hospitalized with 2009 H1N1 influenza and methicillin-resistant Staphylococcus aureus coinfection complicated by severe acute respiratory distress syndrome and multifocal necrotizing pneumonia, with significant lung tissue damage requiring prolonged extracorporeal membrane oxygenation (ECMO) support.

Methods: The development of multiple BPFs precluded lung recruitment necessary to wean from ECMO. Read More

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Progress in Vaccine-Preventable and Respiratory Infectious Diseases-First 10 Years of the CDC National Center for Immunization and Respiratory Diseases, 2006-2015.

Emerg Infect Dis 2018 Jul;24(7):1178-1187

The need for closer linkages between scientific and programmatic areas focused on addressing vaccine-preventable and acute respiratory infections led to establishment of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention. During its first 10 years (2006-2015), NCIRD worked with partners to improve preparedness and response to pandemic influenza and other emergent respiratory infections, provide an evidence base for addition of 7 newly recommended vaccines, and modernize vaccine distribution. Clinical tools were developed for improved conversations with parents, which helped sustain childhood immunization as a social norm. Read More

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July 2018
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Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection.

Chem Commun (Camb) 2018 Jun 19. Epub 2018 Jun 19.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection. Read More

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Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma.

Front Immunol 2018 4;9:1249. Epub 2018 Jun 4.

Research Institute of the McGill University Health Centre, Montréal, QC, Canada.

Infants are exposed to a wide range of potential pathogens in the first months of life. Although maternal antibodies acquired transplacentally protect full-term neonates from many systemic pathogens, infections at mucosal surfaces still occur with great frequency, causing significant morbidity and mortality. At least part of this elevated risk is attributable to the neonatal immune system that tends to favor T regulatory and Th2 type responses when microbes are first encountered. Read More

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The study of effect of didecyl dimethyl ammonium bromide on bacterial and viral decontamination for biosecurity in the animal farm.

Vet World 2018 May 27;11(5):706-711. Epub 2018 May 27.

Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.

Aim: The aim of this study was to determine the effectiveness of the fourth-generation quaternary ammonium compounds, didecyl dimethyl ammonium bromide (DDAB), on the efficacy of bacterial and viral decontamination against pathogens commonly found in livestock industry including infantis (SI), , and avian influenza virus (AIV).

Materials And Methods: The DDAB was prepared at 500, 250, and 125 parts per million (ppm) for absent and present organic material. Meanwhile, 5% of fetal bovine serum in DDAB solution sample was used to mimic the presence of organic material contamination. Read More

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Geriatric influenza death (GID) score: a new tool for predicting mortality in older people with influenza in the emergency department.

Sci Rep 2018 Jun 18;8(1):9312. Epub 2018 Jun 18.

Department of Emergency Medicine, Chi-Mei Medical Center, Tainan, Taiwan.

Although influenza may cause death in the geriatric population, the best method for predicting mortality in this population is still unclear. We retrospectively recruited older people (≥65 yr) with influenza visiting the emergency department (ED) of a medical center between January 1, 2010, and December 31, 2015. We performed univariate and multivariate logistic regression to identify independent mortality predictors and then developed a prediction score. Read More

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Age, calorie restriction, and age of calorie restriction onset reduce maturation of natural killer cells in C57Bl/6 mice.

Nutr Res 2018 Jul 21;55:81-93. Epub 2018 Apr 21.

Department of Food Science and Human Nutrition, Room 236A G. M. Trout FSHN Building, Michigan State University, 469 Wilson Road, East Lansing, MI, USA 48824-1224. Electronic address:

Calorie restriction (CR), also known as energy restriction, has been shown to have a deleterious impact on both adult and aged mouse survival during influenza virus infection. Natural killer (NK) cell phenotypic differences contribute to increased susceptibility of adult CR mice. We hypothesized NK cell phenotype from adult and aged C57Bl/6 mice fed NIH-31 diet ad libitum (AL) would be different from NK cell phenotype from adult and aged mice fed NIH-31/NIA fortified diet at 40% CR. Read More

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Risk factors for avian influenza virus in backyard poultry flocks and environments in Zhejiang Province, China: a cross-sectional study.

Infect Dis Poverty 2018 Jun 19;7(1):65. Epub 2018 Jun 19.

Zhejiang Provincial Centre for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou, Zhejiang, 310051, People's Republic of China.

Background: Human infection of avian influenza virus (AIV) remains a great concern. Although live poultry markets are believed to be associated with human infections, ever more infections have been reported in rural areas with backyard poultry, especially in the fifth epidemic of H7N9. However, limited information is available on backyard poultry infection and surrounding environmental contamination. Read More

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Avian influenza A (H5N1) outbreaks in different poultry farm types in Egypt: the effect of vaccination, closing status and farm size.

BMC Vet Res 2018 Jun 18;14(1):187. Epub 2018 Jun 18.

Spatial Epidemiology Lab. (SpELL), Université Libre de Bruxelles, Brussels, Belgium.

Background: The Avian Influenza A (H5N1) virus is endemic in poultry in Egypt. The winter of 2014/2015 was particularly worrying as new clusters of HPAI A (H5N1) virus emerged, leading to an important number of AI A (H5N1) outbreaks in poultry farms and sporadic human cases. To date, few studies have investigated the distribution of HPAI A (H5N1) outbreaks in Egypt in relation to protective / risk factors at the farm level, a gap we intend to fill. Read More

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Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus.

Viruses 2018 06 16;10(6). Epub 2018 Jun 16.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China.

The productive infection of influenza A virus (IAV) depends on host factors. However, the involvement of long non-coding RNAs (lncRNAs) in IAV infection remains largely uninvestigated. In this work, we have discovered a human lncRNA, named lncRNA-PAAN (PA-associated noncoding RNA) that enhances IAV replication. Read More

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June 2018
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The causes and consequences of variation in human cytokine production in health.

Curr Opin Immunol 2018 Jun 15;54:50-58. Epub 2018 Jun 15.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Cytokines are important cell-signaling molecules that activate and modulate immune responses. Major factors influencing cytokine variation in healthy individuals are host genetics, non-heritable factors and the microbiome. Genetic variation accounts for a significant part of heterogeneity in cytokine production by peripheral blood mononuclear cells. Read More

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Immunization rates of pneumococcal, influenza and tetanus vaccines and knowledge and attitudes of adult patients who receive inpatient treatment at hospital: Point prevalence study.

Hum Vaccin Immunother 2018 Jun 18:1-22. Epub 2018 Jun 18.

g Infectious Diseases and Clinical Microbiology Department , Şişli Hamidiye Etfal Training and ResearchHospital, Health Sciences University , Istanbul , Turkey .

The safety of vaccines, access to health care, the level of community's knowledge and the attention of physicians play a critical role in the rate of adult vaccination. This study aims to determine the immunization rate of pneumococcal, influenza and tetanus vaccines among the patients and their knowledge and attitudes in the hospital. The study is a cross-sectional point prevalence survey. Read More

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Influenza Other Respir Viruses 2018 Jul;12(4):547

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