107,993 results match your criteria Influenza


Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.

J Gerontol A Biol Sci Med Sci 2020 Jun 3. Epub 2020 Jun 3.

University of Massachusetts Amherst.

Skeletal muscle myopathies represent a common non-pulmonary manifestation of influenza infection, leading to reduced physical function and hospitalization in older adults. However, underlying mechanisms remain poorly understood. Our study examined the effects of influenza virus A pulmonary infection on contractile function at the cellular (single fiber) and molecular (myosin-actin interactions and myofilament properties) levels in soleus and extensor digitorum longus muscles of aged (20 months) C57BL/6 male mice that were healthy or flu infected for 7 (7-days post-infection; 7-DPI) or 12 days (12-DPI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/gerona/glaa136DOI Listing

Does COVID-19 infection impact on the trend of seasonal influenza infection? 11 countries and regions, from 2014 to 2020.

Int J Infect Dis 2020 May 31. Epub 2020 May 31.

Department of Healthcare Epidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: Infection due to the 2019 novel coronavirus disease (COVID-19) is widespread dramatically around the world. This COVID-19 pandemic could increase public concern to prevent infectious disease. The present study aimed to assess the relationship between the COVID-19 epidemic and decreasing another infectious disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2020.05.088DOI Listing

Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.

Cell 2020 May 27. Epub 2020 May 27.

Department of Medicine, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA; Department of Immunology, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused global public health and economic crises, necessitating rapid development of vaccines and therapeutic countermeasures. The world-wide response to the COVID-19 pandemic has been unprecedented with government, academic, and private partnerships working together to rapidly develop vaccine and antibody countermeasures. Many of the technologies being used are derived from prior government-academic partnerships for response to other emerging infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2020.05.041DOI Listing

The need of health policy perspective to protect Healthcare Workers during COVID-19 pandemic. A GRADE rapid review on the N95 respirators effectiveness.

PLoS One 2020 3;15(6):e0234025. Epub 2020 Jun 3.

Unit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Protecting Health Care Workers (HCWs) during routine care of suspected or confirmed COVID-19 patients is of paramount importance to halt the SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) pandemic. The WHO, ECDC and CDC have issued conflicting guidelines on the use of respiratory filters (N95) by HCWs. We searched PubMed, Embase and The Cochrane Library from the inception to March 21, 2020 to identify randomized controlled trials (RCTs) comparing N95 respirators versus surgical masks for prevention of COVID-19 or any other respiratory infection among HCWs. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234025PLOS

Preparedness against pandemic influenza: Production of an oil-in-water emulsion adjuvant in Brazil.

PLoS One 2020 3;15(6):e0233632. Epub 2020 Jun 3.

Divisão BioIndustrial, Serviço de Bacteriologia, Instituto Butantan, São Paulo, Brazil.

Increasing pandemic influenza vaccine manufacturing capacity is considered strategic by WHO. Adjuvant use is key in this strategy in order to spare the vaccine doses and by increasing immune protection. We describe here the production and stability studies of a squalene based oil-in-water emulsion, adjuvant IB160, and the immune response of the H7N9 vaccine combined with IB160. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233632PLOS

Combined intranasal nanoemulsion and RIG-I activating RNA adjuvants enhances mucosal, humoral and cellular immunity to influenza virus.

Mol Pharm 2020 Jun 3. Epub 2020 Jun 3.

Current influenza virus vaccines are focused on humoral immunity and are limited by short duration of protection, narrow cross-strain efficacy and sub-optimal immunogenicity. Here, we combined two chemically and biologically distinct adjuvants, an oil-in-water nanoemulsion (NE) and RNA-based agonists of RIG-I to determine whether the diverse mechanisms of these adjuvants could lead to improved immunogenicity and breadth of protection against influenza virus. NE activates TLRs, stimulates immunogenic apoptosis, and enhances cellular antigen uptake, leading to a balanced TH1/TH2/TH17 response when administered intranasally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.0c00315DOI Listing

Cardiovascular Implications in Patients Infected with Covid-19 and the Importance of Social Isolation to Reduce Dissemination of the Disease.

Arq Bras Cardiol 2020 Jun;114(5):834-838

Universidade de Vassouras - Cardiologia,Rio de Janeiro, RJ - Brasil.

Respiratory symptoms, especially the development of severe acute respiratory distress syndrome, dominate the discussion and initial concerns of the population and health professionals. However, the cardiovascular system is greatly affected by these conditions and is often responsible for complications and mortality of these patients. In order to show the cardiovascular implications in patients infected with COVID-19 and the importance of social isolation as an alternative to curb the spread of the disease, a literature review was carried out based on 37 articles, in English, Portuguese and Spanish, available on Scielo and PubMed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36660/abc.20200243DOI Listing

Cold and distant: structural features of the nucleoprotein complex of a cold-adapted influenza A virus strain.

J Biomol Struct Dyn 2020 Jun 3:1-10. Epub 2020 Jun 3.

Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center "Kurchatov Institute", 188300, mkr. Orlova roshcha 1, Gatchina, Russia.

Two influenza A nucleoprotein variants (wild-type: G102R; and mutant: G102R and E292G) were studied with regard to macro-molecular interactions in oligomeric form (24-mers). The E292G mutation has been previously shown to provide cold adaptation. Molecular dynamics simulations of these complexes and trajectory analysis showed that the most significant difference between the obtained models was distance between nucleoprotein complex strands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2020.1776636DOI Listing

[Influenza-associated acute necrotizing encephalitis in an adult].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(4):102-106

Research Center of Neurology, Moscow, Russia.

A rare case of acute necrotizing encephalitis associated with influenza virus in an adult man is described. This clinical case is one of the few published cases in the world literature and the only one in the Russian literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/jnevro2020120041102DOI Listing
January 2020

COVID-19 versus the 1918 influenza pandemic: different virus, different age mortality patterns.

Authors:
G Dennis Shanks

J Travel Med 2020 Jun 2. Epub 2020 Jun 2.

Australian Defence Force Malaria and Infectious Diseases Institute, Enoggera, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jtm/taaa086DOI Listing

Pertussis immunization in healthcare workers working in pediatric settings: Knowledge, Attitudes and Practices (KAP) of Occupational Physicians. Preliminary results from a web-based survey (2017).

J Prev Med Hyg 2020 Mar 2;61(1):E66-E75. Epub 2020 Apr 2.

University "Vita e Salute", San Raffaele Hospital, Milan (MI), Italy.

Introduction: The present study aims to characterize knowledge, attitudes and practices in a sample of occupational physicians (OPh) towards pertussis immunization in healthcare workers (HCWs) from pediatric settings.

Material And Methods: A total of 148 OPh (45.9% males, mean age of 40. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.1.1155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225653PMC

Nursing knowledge, attitude, and practice to influenza vaccination at suburban hospital in West Java, Indonesia.

J Prev Med Hyg 2020 Mar 2;61(1):E15-E20. Epub 2020 Apr 2.

Department of Epidemiology and Biostatistics Faculty of Medicine Universitas Padjadjaran, Indonesia.

Background: High epidemiology of influenza in the world and Indonesia causes some groups to have high risk for getting infected with influenza, one of which is healthcare workers. The low rates of influenza vaccination among healthcare workers, especially in nurses, raise the need for an educational strategy to prevent influenza. This study aimed to measure the level of knowledge, attitude and practice among nurses in suburban hospital in West Java. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.1.1119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225651PMC

An overview of avian influenza in the context of the Australian commercial poultry industry.

One Health 2020 Dec 11;10:100139. Epub 2020 May 11.

The University of Sydney, c15/335 Werombi Rd, Camden, NSW 2570, Australia.

From 1976 Australia has experienced seven highly pathogenic avian influenza (HPAI) outbreaks in poultry farms and there have been a total of 16 confirmed low pathogenic avian influenza (LPAI) cases in poultry in Australia at the time of writing. This paper describes all past LPAI and HPAI detections in Australian poultry and reviews avian influenza risk in the Australian commercial chicken industry. The factors that influence this risk are also discussed; notably the nomadic nature of Australian waterfowl, the increasing demand of free range poultry egg and meat production in Australia, and biosecurity practices implemented across farms including farm separations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.onehlt.2020.100139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256052PMC
December 2020

Differentiating Between 2019 Novel Coronavirus Pneumonia and Influenza Using a Nonspecific Laboratory Marker-Based Dynamic Nomogram.

Open Forum Infect Dis 2020 May 16;7(5):ofaa169. Epub 2020 May 16.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: There is currently a lack of nonspecific laboratory indicators as a quantitative standard to distinguish between the 2019 coronavirus disease (COVID-19) and an influenza A or B virus infection. Thus, the aim of this study was to establish a nomogram to detect COVID-19.

Methods: A nomogram was established using data collected from 457 patients (181 with COVID-19 and 276 with influenza A or B infection) in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofaa169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239104PMC

Oseltamivir and baloxavir: Dual treatment for rapidly developing ARDS on a patient with renal disease.

IDCases 2020 22;21:e00819. Epub 2020 May 22.

Advocate Illinois Medical Center, Internal Medicine Department, 836 W Wellington Ave, Chicago, IL 60657, United States.

Influenza is an annual epidemic disease that in severe cases can lead to the development of ARDS. Current practice recommends the routine use of neuraminidase inhibitors with emerging evidence for the use of endonuclease inhibitors. We present the case of a 22-year-old female with diabetes and IgG4 tubulo-interstitial nephritis that developed rapidly progressive ARDS from influenza infection requiring ventilatory support and extra corporeal oxygenation in which oseltamivir and baloxavir were used in combination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2020.e00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256313PMC

Transmissibility of influenza during the 21st-century epidemics, Spain, influenza seasons 2001/02 to 2017/18.

Euro Surveill 2020 May;25(21)

The members of the network are listed at the end of this article.

BackgroundUnderstanding influenza seasonality is necessary for determining policies for influenza control.AimWe characterised transmissibility during seasonal influenza epidemics, including one influenza pandemic, in Spain during the 21th century by using the moving epidemic method (MEM) to calculate intensity levels and estimate differences across seasons and age groups.MethodsWe applied the MEM to Spanish Influenza Sentinel Surveillance System data from influenza seasons 2001/02 to 2017/18. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.21.1900364DOI Listing

Using web search queries to monitor influenza-like illness: an exploratory retrospective analysis, Netherlands, 2017/18 influenza season.

Euro Surveill 2020 May;25(21)

Nivel (Netherlands Institute for Health Service Research), Utrecht, Netherlands.

BackgroundDespite the early development of Google Flu Trends in 2009, standards for digital epidemiology methods have not been established and research from European countries is scarce.AimIn this article, we study the use of web search queries to monitor influenza-like illness (ILI) rates in the Netherlands in real time.MethodsIn this retrospective analysis, we simulated the weekly use of a prediction model for estimating the then-current ILI incidence across the 2017/18 influenza season solely based on Google search query data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.21.1900221DOI Listing

Severe Complicated Influenza Declined During the Prevention of COVID-19 in Taiwan.

Infect Control Hosp Epidemiol 2020 Jun 3:1-8. Epub 2020 Jun 3.

Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/ice.2020.272DOI Listing

The impact of climate and antigenic evolution on seasonal influenza virus epidemics in Australia.

Nat Commun 2020 Jun 2;11(1):2741. Epub 2020 Jun 2.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Although seasonal influenza viruses circulate globally, prevention and treatment occur at the level of regions, cities, and communities. At these scales, the timing, duration and magnitude of epidemics vary substantially, but the underlying causes of this variation are poorly understood. Here, based on analyses of a 15-year city-level dataset of 18,250 laboratory-confirmed and antigenically-characterised influenza virus infections from Australia, we investigate the effects of previously hypothesised environmental and virological drivers of influenza epidemics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-16545-6DOI Listing

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus.

Signal Transduct Target Ther 2020 Jun 3;5(1):74. Epub 2020 Jun 3.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Influenza epidemics and pandemics are constant threats to global public health. Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection, the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains. Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-020-0174-2DOI Listing

Modeling mitigation of influenza epidemics by baloxavir.

Nat Commun 2020 Jun 2;11(1):2750. Epub 2020 Jun 2.

Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.

Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-16585-yDOI Listing

Severe respiratory failure in an immunocompetent host with invasive pulmonary aspergillosis and H1N1 influenza.

Infez Med 2020 Jun;28(2):263-267

Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy.

Invasive pulmonary aspergillosis (IPA) is a life-threatening condition that usually occurs in immunocompromised hosts. However, according to recent reports it can affect immunocompetent hosts with severe influenza infection due to viral-dependent disruption of respiratory immune defenses. We present the case of a 61-year-old Caucasian man admitted to the Emergency Department with respiratory failure and fever, who was diagnosed with H1N1 influenza and IPA. Read More

View Article

Download full-text PDF

Source

Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report.

BMC Infect Dis 2020 Jun 1;20(1):388. Epub 2020 Jun 1.

Influenza Virus Research Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo, 208-0011, Japan.

Background: Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children.

Case Presentation: A 22-month-old girl presented with her first episode of febrile status epilepticus, after which she developed acute pulmonary edema and respiratory failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05115-2DOI Listing

Influenza Vaccination Rate and Factors Associated With Compliance Among Health Care Employees in Large and Medium Acute Care Hospitals.

Am J Med Qual 2020 Jun 2:1062860620929423. Epub 2020 Jun 2.

Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Annual influenza epidemics are associated with high morbidity and mortality worldwide, with vaccinations being the main preventive intervention; however, the compliance rate of health care employees remains low. Study aims were to examine vaccination rates among physicians and nurses in surgical and medicine wards, compare between medium and large tertiary hospitals, and identify factors associated with increased vaccination rates. Structured questionnaires were distributed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1062860620929423DOI Listing

Composting Reduces the Vitality of H9N2 in Poultry Manure and EMCV in Pig Manure Allowing for an Environmentally Friendly Use of These Animal Wastes: A Preliminary Study.

Microorganisms 2020 May 31;8(6). Epub 2020 May 31.

Department of Animal Biosystems Science, Chungnam National University, Daejeon 34134, Korea.

In our study, we monitored the inactivation of two important viruses that are critical in animal husbandry throughout the world. To evaluate the influence of the composting process on inactivation of avian influenza virus (H9N2) in poultry manure compost (PMC) and Encephalomyocarditis virus (EMCV) in pig (swine) manure compost (SMC), the H9N2 and EMCV were injected in dialysis cassettes and buried in two different manure compost piles of poultry and pig manure, respectively. The highest temperature achieved in the PMC and SMC piles during the test period were 75 °C and 73. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms8060829DOI Listing

Seasonal Influenza Vaccination and Recommendation: The Difference between General Practitioners and Public Health Workers in China.

Vaccines (Basel) 2020 May 31;8(2). Epub 2020 May 31.

China Center for Health Development Studies, Peking University, Beijing 100083, China.

Seasonal influenza vaccination for healthcare workers (HCWs) is critical to the protection of HCWs and their patients. This study examined whether the separation of public health workers and general practitioners could affect the influenza vaccine uptake and recommendation behaviors among HCWs in China. A survey was conducted from August to October 2019, and HCWs from 10 provinces in China were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines8020265DOI Listing

Impact of Influenza Vaccination on All-Cause Mortality and Hospitalization for Pneumonia in Adults and the Elderly with Diabetes: A Meta-Analysis of Observational Studies.

Vaccines (Basel) 2020 May 30;8(2). Epub 2020 May 30.

Diabetology, Careggi Hospital and University of Florence, 50134 Florence, Italy.

Diabetes is a chronic condition that can be worsened by complications such as seasonal influenza virus infections. The aim of the present meta-analysis is the systematic retrieval and analysis of all available evidence on the effects of an influenza vaccine on diabetic patients. We conducted a systematic review and meta-analysis by searching MEDLINE, Embase and the Cochrane databases from inception until April 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines8020263DOI Listing

2019 Influenza Vaccination Campaign in an Italian Research and Teaching Hospital: Analysis of the Reasons for Its Failure.

Int J Environ Res Public Health 2020 May 30;17(11). Epub 2020 May 30.

Postgraduate School in Public Health, Department Biomedical Sciences for Health, University of Milano, 20136 Milano, Italy.

Despite recommendations, the influenza vaccination coverage rate in healthcare workers (HCWs) in Italy is far from the recommended target. The aim of the study is to analyze the influenza vaccination campaign performed in 2019 in a research and teaching hospital in Milan. The vaccination strategy included an ad hoc ambulatory, as in the previous years, and an onsite ambulatory, introduced for the first time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17113881DOI Listing

Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding.

Viruses 2020 May 30;12(6). Epub 2020 May 30.

Division of Basic Sciences Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.

Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA). Because HA is essential for viral entry, antibodies targeting HA often potently neutralize the virus in single-cycle infection assays. However, antibodies against NA are not potently neutralizing in such assays, since NA is dispensable for single-cycle infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v12060597DOI Listing

Age-Dependent Lethality in Ducks Caused by Highly Pathogenic H5N6 Avian Influenza Virus.

Viruses 2020 May 29;12(6). Epub 2020 May 29.

Laboratory of Influenza Research and College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.

Ducks show notably higher resistance to highly pathogenic avian influenza viruses as compared to chickens. Here, we studied the age-dependent susceptibility in ducks to the infections caused by highly pathogenic avian influenza viruses. We intranasally infected ducks aged 1, 2, 4, and 8 weeks with highly pathogenic H5N6 avian influenza viruses isolated in South Korea in 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v12060591DOI Listing

Non-Mouse-Adapted H1N1pdm09 Virus as a Model for Influenza Research.

Viruses 2020 May 29;12(6). Epub 2020 May 29.

Department of Virology, Federal State Budgetary Scientific Institution "Institute of Experimental Medicine", 197376 St Petersburg, Russia.

The number of lung-adapted influenza viruses is limited. Most of them are not antigenically related to current circulating viruses. Viruses similar to recent strains are required for screening modern antiviral compounds and studying new vaccine candidates against novel influenza viruses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v12060590DOI Listing

Study of Neuraminidase-Inhibiting Antibodies in Clinical Trials of Live Influenza Vaccines.

Antibodies (Basel) 2020 May 29;9(2). Epub 2020 May 29.

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine", Saint Petersburg 197376, Russia.

Background: Currently, the immunogenicity of influenza vaccines is assessed by detecting an increase of hemagglutination inhibition (HI) antibodies. As neuraminidase (NA)-based immunity may be significant in protecting against influenza infection, detection of neuraminidase inhibiting (NI) antibodies may improve the assessment of the immunogenicity of influenza vaccines.

Methods: We investigated the immune response to NA in people after immunization with live influenza vaccines (LAIVs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antib9020020DOI Listing

Age-related factors that affect B cell responses to vaccination in mice and humans.

Immunol Rev 2020 Jun 2. Epub 2020 Jun 2.

UConn Center on Aging, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, USA.

Aging significantly changes the ability to respond to vaccinations and infections. In this review, we summarize published results on age-related changes in response to infection with the influenza virus and on the factors known to increase influenza risk infection leading to organ failure and death. We also summarize how aging affects the response to the influenza vaccine with a special focus on B cells, which have been shown to be less responsive in the elderly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12864DOI Listing

Influenza A(H1N1)pdm09 but not A(H3N2) virus infection induces durable sero-protection: results from the Ha Nam Cohort.

J Infect Dis 2020 Jun 2. Epub 2020 Jun 2.

Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.

Background: The extent to which influenza recurrence depends upon waning immunity from prior-infection is undefined. We used antibody titres of Ha-Nam cohort participants to estimate protection curves and decay trajectories.

Methods: 270 households participated in influenza-like-illness surveillance and provided blood at intervals spanning RTPCR-confirmed transmission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiaa293DOI Listing

Oral immunization with an attenuated Gallinarum encoding the H9N2 hemagglutinin and M2 ectodomain induces protective immune responses against H9N2 infection in chickens.

Avian Pathol 2020 Jun 2:1-38. Epub 2020 Jun 2.

College of Veterinary Medicine, Jeonbuk National University, Iksan, 54596, Republic of Korea.

H9N2, a low pathogenic avian influenza (LPAI) virus, causes significant economic losses in the poultry industry worldwide. Herein, we describe the construction of an attenuated Gallinarum (SG) strain for expression and delivery of H9N2 hemagglutinin (HA) 1 (SG-HA1), HA2 (SG-HA2) and/or the conserved matrix protein 2 ectodomain (SG-M2e). We demonstrated that recombinant SG strains expressing HA1, HA2 and M2e antigens were immunogenic and safe in a chicken model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03079457.2020.1775782DOI Listing

Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS.

Pediatr Pulmonol 2020 Jun 1. Epub 2020 Jun 1.

Division of Pediatric Pulmonology, Miller School of Medicine, University of Miami, Miami, Florida.

Many respiratory viral infections such as influenza and measles result in severe acute respiratory symptoms and epidemics. In the spring of 2003, an epidemic of coronavirus pneumonia spread from Guangzhou to Hong Kong and subsequently to the rest of the world. The WHO coined the acronym SARS (severe acute respiratory syndrome) and subsequently the causative virus as SARS-CoV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24810DOI Listing

Factors in B cell competition and immunodominance.

Immunol Rev 2020 Jun 1. Epub 2020 Jun 1.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.

The majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective antibodies are elicited to respond are not well understood. Interclonal B cell competition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in designing effective vaccines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12861DOI Listing

The Real Impact of the Coronavirus Disease 2019 (covid-19) on the Pregnancy Outcome.

Rev Bras Ginecol Obstet 2020 May 29;42(5):303-304. Epub 2020 May 29.

Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

The COVID-19 outbreak is increasing around the world in the number of cases, deaths, and affected countries. Currently, the knowledge regarding the clinical impact of COVID-19 on maternal, fetal, and placental aspects of pregnancy is minimal. Although the elderly and men were the most affected population, in previous situations, such as the 2009 H1N1 influenza pandemic and the Ebola epidemic, pregnant women were more likely to develop complications than nonpregnant women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1712942DOI Listing

Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008-2015.

Virus Genes 2020 Jun 1. Epub 2020 Jun 1.

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared to other geographical regions affected by other genetic clades of the virus. However, there is limited information on the genetic diversity of HPAI H5N1 viruses, especially those isolated from humans in Indonesia. In this study, the genetic and antigenic characteristics of 35 HPAI H5N1 viruses isolated from humans were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11262-020-01765-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262163PMC

Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status.

Vaccine 2020 May 29. Epub 2020 May 29.

Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. Electronic address:

Administration of vaccines during pregnancy provides maternal protection against infectious diseases. This protection is extended to their infants during the first months of life, as pathogen-specific antibodies formed in response to maternal vaccination are transferred across the placenta to the fetus. Notably, Tdap (tetanus-diphtheria-acellular pertussis) vaccination booster is routinely administered to pregnant women both to prevent neonatal tetanus and to ensure that infants have protective levels of pertussis antibodies until they are able to establish their own vaccine-induced levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2020.05.036DOI Listing

Fungal antigenemia in patients with severe Coronavirus disease 2019 (COVID-19): The facts and challenges.

J Microbiol Immunol Infect 2020 May 25. Epub 2020 May 25.

Influenza Reference Laboratory, Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmii.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247483PMC

Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?

J Microbiol Immunol Infect 2020 May 23. Epub 2020 May 23.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Co-infection has been reported in patients with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, but there is limited knowledge on co-infection among patients with coronavirus disease 2019 (COVID-19). The prevalence of co-infection was variable among COVID-19 patients in different studies, however, it could be up to 50% among non-survivors. Co-pathogens included bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumonia, Legionella pneumophila and Acinetobacter baumannii; Candida species and Aspergillus flavus; and viruses such as influenza, coronavirus, rhinovirus/enterovirus, parainfluenza, metapneumovirus, influenza B virus, and human immunodeficiency virus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmii.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245213PMC

Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation.

Viruses 2020 May 28;12(6). Epub 2020 May 28.

Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.

Pigs play an important role in the interspecies transmission of influenza A viruses (IAV). The porcine airway epithelium contains binding sites for both swine/human IAV (α2,6-linked sialic acids) and avian IAV (α2,3-linked sialic acids) and therefore is suited for adaptation of viruses from other species as suggested by the "mixing vessel theory". Here, we applied well-differentiated swine airway epithelial cells to find out whether efficient infection by avian IAV requires prior adaption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v12060589DOI Listing

Trend of respiratory pathogens during the COVID-19 epidemic.

J Clin Virol 2020 May 26;129:104470. Epub 2020 May 26.

National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.

In Italy, the first SARS-CoV-2 infections were diagnosed in Rome, Lazio region, at the end of January 2020, but sustained transmission occurred later, since the end of February. From 1 February to 12 April 2020, 17,164 nasopharyngeal swabs were tested by real time PCR for the presence of SARS-CoV-2 at the Laboratory of Virology of National Institute for Infectious Diseases "Lazzaro Spallanzani" (INMI) in Rome. In the same period, coincident with the winter peak of influenza and other respiratory illnesses, 847 samples were analyzed by multiplex PCR assay for the presence of common respiratory pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2020.104470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255241PMC

Medical mask versus cotton mask for preventing respiratory droplet transmission in micro environments.

Sci Total Environ 2020 May 18;735:139510. Epub 2020 May 18.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

The objective of this study was to investigate whether cotton mask worn by respiratory infection person could suppress respiratory droplet levels compared to medical mask. We recruited adult volunteers with confirmed influenza and suspected cases of coronavirus disease 2019 (COVID-19) to wear medical masks and self-designed triple-layer cotton masks in a regular bedroom and a car with air conditioning. Four 1-hour repeated measurements (two measurements for bedroom the others for car) of particles with a size range of 20-1000 nm measured by number concentrations (NC), temperature and relatively humidity, and cough/sneeze counts per hour were conducted for each volunteer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139510DOI Listing

Expression pattern of the interferon regulatory factor family members in influenza virus induced local and systemic inflammatory responses.

Clin Immunol 2020 May 29:108469. Epub 2020 May 29.

Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, PR China; Institute of Pediatrics, First Hospital of Jilin University, Jilin University, Changchun 130021, PR China. Electronic address:

Type I interferon is considered to be a key cytokine in influenza virus-induced acute lung injury (ALI), in which IRF3 and IRF7 play particularly important roles. However, whether all nine members of IRF family are involved in influenza virus-induced immune response is currently unknown. In this study, we found that all members of IRF family responded to influenza virus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108469DOI Listing

Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.

Virus Res 2020 May 29:198040. Epub 2020 May 29.

Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Núcleo de Bioinformática do Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil. Electronic address:

The interactions between chemokine receptors and their ligands may affect susceptibility to infectious diseases as well as their clinical manifestations. These interactions mediate both the traffic of inflammatory cells and virus-associated immune responses. In the context of viral infections, the human C-C chemokine receptor type 5 (CCR5) receives great attention from the scientific community due to its role as an HIV-1 co-receptor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2020.198040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260533PMC

Liposomes as tunable platform to decipher the antitumor immune response triggered by TLR and NLR agonists.

Eur J Pharm Biopharm 2020 May 29. Epub 2020 May 29.

Université de Strasbourg, CNRS, 3Bio team, Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch Cedex, France. Electronic address:

Liposomes are powerful tools for the optimization of peptides and adjuvant composition in cancer vaccines. Here, we take advantage of a liposomal platform versatility to develop three vaccine candidates associating a peptide from HA influenza virus protein as CD4 epitope, a peptide from HPV16 E7 oncoprotein as CD8 epitope and TLR4, TLR2/6 or NOD1 agonists as adjuvant. Liposomal vaccine containing MPLA (TLR4 liposomes), are the most effective treatment against the HPV-transformed orthotopic lung tumor mouse model, TC-1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2020.05.026DOI Listing

Seasonal influenza vaccination for children with special risk medical conditions: Does policy meet practice?

J Paediatr Child Health 2020 Jun 1. Epub 2020 Jun 1.

Discipline of Paediatrics, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Aim: Ensuring children with special risk medical conditions (SRMC) are protected from influenza is important. The study objective was to describe influenza vaccination practices of medical professionals caring for children with SRMC and explore characteristics associated with a vaccine recommendation.

Methods: Design: Cross-sectional survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jpc.14943DOI Listing