101,627 results match your criteria Influenza


Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
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http://dx.doi.org/10.5694/mja2.50125DOI Listing

Hydrophobic-interaction chromatography for purification of influenza A and B virus.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 1;1117:103-117. Epub 2019 Apr 1.

Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; Chair of Bioprocess Engineering, Otto-von-Guericke University, 39106 Magdeburg, Germany.

Options for hydrophobic-interaction chromatography (HIC) for purification of cell culture-derived influenza A and B virus have been assessed using a 96-well plate format using a semi-high-throughput approach. Follow-up experiments at preparative scale were used to characterize dynamic binding capacity, viral hemagglutinin protein (HA protein) recovery, and the influence of influenza virus (IV) strains on yield and contamination levels. Virus recoveries of up to 96% with a residual DNA level of about 1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.03.037DOI Listing

Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1.

Vaccine 2019 Apr 17. Epub 2019 Apr 17.

Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Sandtorstr. 1, 39106 Magdeburg, Germany; Chair for Bioprocess Engineering, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.

Seasonal and pandemic influenza respiratory infections are still a major public health issue. Vaccination is the most efficient way to prevent influenza infection. One option to produce influenza vaccines is cell-culture based virus propagation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193048
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http://dx.doi.org/10.1016/j.vaccine.2019.04.030DOI Listing
April 2019
2 Reads

Vaccination of the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient.

Infect Dis Clin North Am 2019 Jun;33(2):593-609

Infectious Disease Service, Department of Medicine, Weill Cornell Medical College, 275 York Avenue, Box 420, New York, NY 10065, USA.

Patients with hematologic malignancy or those who undergo hematopoietic stem cell transplantation experience variable degrees of immunosuppression, dependent on underlying disease, therapy received, time since transplant, and complications, such as graft-versus-host disease. Vaccination is an important strategy to mitigate onset and severity of certain vaccine-preventable illnesses, such as influenza, pneumococcal disease, or varicella zoster infection, among others. This article highlights vaccines that should and should not be used in this patient population and includes general guidelines for timing of vaccination administration and special considerations in the context of newer therapies, recent vaccine developments, travel, and considerations for household contacts. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.007DOI Listing

Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.

Clin Microbiol Infect 2019 Apr 17. Epub 2019 Apr 17.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

Objectives: We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.

Methods: This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.012DOI Listing

Comparison of nucleic acid extraction methods for next-generation sequencing of avian influenza A virus from ferret respiratory samples.

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30329, USA. Electronic address:

Influenza A virus is a negative-sense RNA virus with a segmented genome consisting of eight RNA segments. Avian influenza A virus (AIV) primarily infects avian hosts and sporadically infects mammals, which can lead to adaptation to new species. Next-generation sequencing (NGS) of emerging AIV genomes extracted from respiratory samples collected on sequential days from animal models and clinical patients enables analysis of the emergence of evolutionary variants within the virus population over time. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.014DOI Listing

Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Respiratory tract infections due to community-acquired respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause severe symptoms including pneumonia and bronchiolitis and can be fatal. Given the lack of effective antivirals and the data from our group demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells can be clinically beneficial for the treatment of both latent (Epstein-Barr virus, cytomegalovirus, BK virus, human herpesvirus 6) and lytic (adenovirus) viruses, we investigated the potential for extending this immunotherapeutic approach to respiratory viruses. We now describe a system that rapidly generates a single preparation of polyclonal (CD4+ and CD8+) virus-specific T cells reactive against 12 antigens derived from 4 viruses (respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus) that commonly cause post-transplant morbidity and mortality. Read More

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http://dx.doi.org/10.3324/haematol.2018.206896DOI Listing

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.

Sci Immunol 2019 Apr;4(34)

HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cell level after vaccination with a replication-competent adenovirus type 4 recombinant virus expressing influenza H5 hemagglutinin. Fluorescent H1 or H5 probes were used to quantitate and isolate peripheral blood B cells and their antigen receptors. Read More

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http://dx.doi.org/10.1126/sciimmunol.aau2710DOI Listing

Emergence of human infection with Jingmen tick virus in China: A retrospective study.

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address:

Background: A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans.

Methods: We obtained skin-biopsy, blood and serum samples from patients with tick bites, and used high-throughput sequencing, in situ hybridisation, and serologic testing to diagnose and ascertain the cases of JMTV infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193023
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http://dx.doi.org/10.1016/j.ebiom.2019.04.004DOI Listing
April 2019
1 Read

Association of State Laws With Influenza Vaccination of Hospital Personnel.

Am J Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Division of Healthcare Quality Promotion, National Center for Emerging Infectious and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: Healthcare personnel influenza vaccination can reduce influenza illness and patient mortality. State laws are one tool promoting healthcare personnel influenza vaccination.

Methods: A 2016 legal assessment in 50 states and Washington DC identified (1) assessment laws: mandating hospitals assess healthcare personnel influenza vaccination status; (2) offer laws: mandating hospitals offer influenza vaccination to healthcare personnel; (3) ensure laws: mandating hospitals require healthcare personnel to demonstrate proof of influenza vaccination; and (4) surgical masking laws: mandating unvaccinated healthcare personnel to wear surgical masks during influenza season. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193005
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http://dx.doi.org/10.1016/j.amepre.2019.01.011DOI Listing
April 2019
1 Read

Haemophagocytic lymphohistiocytosis induced by A/H1N1 influenza.

Presse Med 2019 Apr 16. Epub 2019 Apr 16.

Habib Bourguiba University Hospital, Department of Intensive Care, Sfax, Tunisia.

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http://dx.doi.org/10.1016/j.lpm.2019.02.034DOI Listing

Antiviral Therapy for the Next Influenza Pandemic.

Authors:
Aeron C Hurt

Trop Med Infect Dis 2019 Apr 18;4(2). Epub 2019 Apr 18.

WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Read More

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http://dx.doi.org/10.3390/tropicalmed4020067DOI Listing
April 2019
2 Reads

Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection.

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x virus-like particles (VLP)) as a cross-protective influenza vaccine candidate. Co-delivery of influenza split vaccine and M2e5x VLP to the skin by MN patch was found to confer effective protection against heterosubtypic influenza virus by preventing weight loss and reducing lung viral loads. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040188DOI Listing

Virus survival and fitness when multiple genotypes and subtypes of influenza A viruses exist and circulate in swine.

Virology 2019 Apr 9;532:30-38. Epub 2019 Apr 9.

Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA. Electronic address:

We performed swine influenza virus (SIV) surveillance in Midwest USA and isolated 100 SIVs including endemic and reassortant H1 and H3 viruses with 2009 pandemic H1N1 genes. To determine virus evolution when different genotypes and subtypes of influenza A viruses circulating in the same swine herd, a virus survival experiment was conducted in pigs mimicking field situations. Five different SIVs were used to infect five pigs individually, then two groups of sentinel pigs were introduced to investigate virus transmission. Read More

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http://dx.doi.org/10.1016/j.virol.2019.03.016DOI Listing

The epidemic potential of avian influenza A (H7N9) virus in humans in mainland China: A two-stage risk analysis.

PLoS One 2019 19;14(4):e0215857. Epub 2019 Apr 19.

Department of Epidemiology and Biostatistics, School of Public Health, Sichuan University, Chengdu, Sichuan, China.

Background: From 2013 to 2017, more than one thousand avian influenza A (H7N9) confirmed cases with hundreds of deaths were reported in mainland China. To identify priorities for epidemic prevention and control, a risk assessing framework for subnational variations is needed to define the epidemic potential of A (H7N9).

Methods: We established a consolidated two-stage framework that outlined the potential epidemic of H7N9 in humans: The Stage 1, index-case potential, used a Boosted Regression Trees model to assess population at risk due to spillover from poultry; the Stage 2, epidemic potential, synthesized the variables upon a framework of the Index for Risk Management to measure epidemic potential based on the probability of hazards and exposure, the vulnerability and coping capacity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215857PLOS
April 2019
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Vaccination of Solid Organ Transplant Candidates and Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Apr 19:e13563. Epub 2019 Apr 19.

Transplant Infectious Diseases, University Health Network, Toronto, ON.

These updated guidelines of the AST IDCOP review vaccination of solid organ transplant candidates and recipients. General principles of vaccination as well as the use of specific vaccines in this population are discussed. Vaccination should be reviewed in the pre-transplant setting and appropriate vaccines updated. Read More

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http://dx.doi.org/10.1111/ctr.13563DOI Listing

Contrasting effects of host species and phylogenetic diversity on the occurrence of HPAI H5N1 in European wild birds.

J Anim Ecol 2019 Apr 19. Epub 2019 Apr 19.

Resource Ecology Group, Wageningen University, 6708PB, Wageningen, The Netherlands.

Studies on the highly pathogenic avian influenza (HPAI) H5N1 suggest that wild bird migration may facilitate its long-distance spread, yet the role of wild bird community composition in its transmission risk remains poorly understood. Furthermore, most studies on the diversity-disease relationship focused on host species diversity without considering hosts' phylogenetic relationships, which may lead to rejecting a species diversity effect when the community has host species that are only distantly related. Here, we explored the influence of waterbird community composition for determining HPAI H5N1 occurrence in wild birds in a continental-scale study across Europe. Read More

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http://dx.doi.org/10.1111/1365-2656.12997DOI Listing

Can awake ECMO combined with NPPV treat severe H7N9 avian influenza? A case report.

QJM 2019 Apr 19. Epub 2019 Apr 19.

Department of Critical Care Medicine, Research Center for functional maintenance and reconstruction of viscera, Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Wuhu, China.

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https://academic.oup.com/qjmed/advance-article/doi/10.1093/q
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http://dx.doi.org/10.1093/qjmed/hcz087DOI Listing
April 2019
2 Reads

Risk assessment of the tropism & pathogenesis of the highly pathogenic avian influenza A/H7N9 virus using ex vivo & in vitro cultures of human respiratory tract.

J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Highly pathogenic avian influenza (HPAI)-H7N9 virus arising from low pathogenic avian influenza (LPAI)-H7N9 virus with polybasic amino acid substitutions in the haemagglutinin was detected in 2017. We compared the tropism, replication competence and cytokine induction of HPAI-H7N9, LPAI-H7N9 and HPAI-H5N1 in ex vivo human respiratory tract explants and in vitro culture of human alveolar epithelial cells (AECs) and pulmonary microvascular endothelial cells (HMVEC-L). Replication competence of HPAI- and LPAI-H7N9 were comparable in ex vivo cultures of bronchus and lung. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz165DOI Listing
April 2019
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Bronchoalveolar Lavage Fluid-Derived Exosomes: A Novel Role Contributing to Lung Cancer Growth.

Front Oncol 2019 2;9:197. Epub 2019 Apr 2.

Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Exosomes are nanovesicles produced by a number of different cell types and regarded as important mediators of cell-to-cell communication. Although bronchoalveolar lavage fluid (BALF) has been shown to be involved in the development of tumors, its role in lung cancer (LC) remains unclear. In this article, we systemically studied BALF-derived exosomes in LC. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00197/
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http://dx.doi.org/10.3389/fonc.2019.00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454045PMC
April 2019
1 Read

Structures and functions linked to genome-wide adaptation of human influenza A viruses.

Sci Rep 2019 Apr 18;9(1):6267. Epub 2019 Apr 18.

Department for Computational Biology of Infection Research, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany.

Human influenza A viruses elicit short-term respiratory infections with considerable mortality and morbidity. While H3N2 viruses circulate for more than 50 years, the recent introduction of pH1N1 viruses presents an excellent opportunity for a comparative analysis of the genome-wide evolutionary forces acting on both subtypes. Here, we inferred patches of sites relevant for adaptation, i. Read More

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http://www.nature.com/articles/s41598-019-42614-y
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http://dx.doi.org/10.1038/s41598-019-42614-yDOI Listing
April 2019
1 Read

Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells.

Cell Death Dis 2019 Apr 18;10(5):337. Epub 2019 Apr 18.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Maternal influenza infection during pregnancy was reported multiple times as the possible cause of many defects and congenital anomalies. Apart from several cases of influenza-related miscarriage during various trimesters of pregnancy, some epidemiological data suggest a link between maternal influenza infection and genetic abnormalities in offspring. However, there are no reports yet describing how maternal influenza alters cellular pathways at early stages of development to result in congenital defects in the fetus. Read More

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http://www.nature.com/articles/s41419-019-1567-4
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http://dx.doi.org/10.1038/s41419-019-1567-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472374PMC
April 2019
1 Read

Evolutionary analysis of influenza A(H1N1)pdm09 during the pandemic and post-pandemic period in Pakistan.

J Infect Public Health 2019 Apr 15. Epub 2019 Apr 15.

Department of Virology, National Institute of Health, Chak Shahzad, Islamabad, Pakistan.

Background: The first case of influenza A(H1N1)pdm09 was detected in Pakistan in June 2009. Since then, it has continued to circulate causing considerable morbidity and mortality. The purpose of this study was to evaluate the evolutionary changes in influenza A(H1N1)pdm09 viruses from 2009 to 2016 and their relevance to the current vaccine viruses. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.008DOI Listing

More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

J Clin Virol 2019 Apr 7;116:11-17. Epub 2019 Apr 7.

Department of Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives: Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study Design: A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193007
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http://dx.doi.org/10.1016/j.jcv.2019.04.003DOI Listing
April 2019
1 Read

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.

Environ Int 2019 Apr 15;127:720-729. Epub 2019 Apr 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States of America. Electronic address:

Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd worsened inflammation in response to sub-lethal H1N1 infection. Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.054DOI Listing

Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients.

J Pharm Sci 2019 Apr 15. Epub 2019 Apr 15.

Project Management Department, Shionogi & Co., Ltd., Osaka, Japan.

Baloxavir marboxil is a prodrug of baloxavir acid, an inhibitor of cap-dependent endonuclease, and suppresses the replication of influenza virus. The aim of this study is to investigate its pharmacokinetic characteristics in Japanese pediatrics. Population pharmacokinetic analysis was conducted for baloxavir acid with 328 plasma concentration data points in a clinical study of 107 Japanese pediatric influenza patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223549193023
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http://dx.doi.org/10.1016/j.xphs.2019.04.010DOI Listing
April 2019
3 Reads

Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.

JCI Insight 2019 Apr 18;5. Epub 2019 Apr 18.

Epidemiological findings indicate that coinfection with influenza viruses is associated with an increased risk of death in patients suffering from tuberculosis but the underlying pathomechanisms are not well understood. In this study, we demonstrate that influenza A virus (IAV) coinfection rapidly impairs control of Mycobacterium tuberculosis (Mtb) in C57BL/6 mice. IAV coinfection was associated with significantly increased bacterial loads, reduced survival and a substantial modulation of innate and adaptive immune defenses including an impaired onset and development of Mtb-specific CD4+ T cell responses and the accumulation of macrophages with increased arginase-1 production in the lungs. Read More

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http://insight.jci.org/articles/view/126533
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http://dx.doi.org/10.1172/jci.insight.126533DOI Listing
April 2019
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The Eighteen of 1918-1919: Black Nurses and the Great Flu Pandemic in the United States.

Am J Public Health 2019 Apr 18:e1-e8. Epub 2019 Apr 18.

At the time of the study, Marian Moser Jones and Matilda Saines were with the University of Maryland School of Public Health, College Park.

This article examines the role of Black American nurses during the 1918-1919 influenza pandemic and the aftermath of World War I. The pandemic caused at least 50 million deaths worldwide and 675 000 in the United States. It occurred during a period of pervasive segregation and racial violence, in which Black Americans were routinely denied access to health, educational, and political institutions. Read More

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https://ajph.aphapublications.org/doi/10.2105/AJPH.2019.3050
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http://dx.doi.org/10.2105/AJPH.2019.305003DOI Listing
April 2019
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Surface-Independent and Oriented Immobilization of Antibody via One-Step Polydopamine/Protein G Coating: Application to Influenza Virus Immunoassay.

Macromol Biosci 2019 Apr 18:e1800486. Epub 2019 Apr 18.

Bionanotechnology Research Center, KRIBB, Daejeon, 34141, Korea.

For the construction of high-performance biosensor, it is important to interface bioreceptors with the sensor surface densely and in the optimal orientation. Herein, a simple surface modification method that can optimally immobilize antibodies onto various kinds of surfaces is reported. For the surface modification, a mixture of polydopamine (PDA) and protein G was employed. Read More

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http://dx.doi.org/10.1002/mabi.201800486DOI Listing

Generation of a purely clonal defective interfering influenza virus.

Microbiol Immunol 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan.

A defective interfering (DI) influenza virus carries a large deletion in a viral gene segment and shows potential for antiviral therapy by interfering with the replication of infectious virus. However, because a DI virus cannot replicate autonomously without the aid of an infectious helper virus, clonal DI virus stocks without contamination of the helper virus have not been generated. To overcome this problem, we generated a clonal DI virus with a PB2 DI gene by reverse genetics, amplified the clonal DI virus using a cell line stably expressing the PB2 protein, and confirmed its ability to interfere with infectious virus replication in vitro. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1348-0421.12
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http://dx.doi.org/10.1111/1348-0421.12681DOI Listing
April 2019
1 Read

Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017.

PeerJ 2019 11;7:e6748. Epub 2019 Apr 11.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Children and adults residing in densely populated urban centers around the world are at risk of seasonal influenza-like illness caused by respiratory viruses such as influenza virus, human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). In a large metropolitan of Thailand's capital city Bangkok, most respiratory infections are rarely confirmed by molecular diagnostics. We therefore examined the frequency of RSV, hMPV, and influenza virus in 8,842 patients who presented influenza-like illness and sought medical care at a large hospital in Bangkok between 2016 and 2017. Read More

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http://dx.doi.org/10.7717/peerj.6748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462397PMC
April 2019
1 Read

Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka.

BMJ Glob Health 2019 30;4(2):e001291. Epub 2019 Mar 30.

School of Medicine, Duke University, Durham, North Carolina, USA.

Background: Acute respiratory infections are a common reason for antibiotic overuse. We previously showed that providing Sri Lankan clinicians with positive rapid influenza test results was associated with a reduction in antibiotic prescriptions. The economic impact of influenza diagnostic strategies is unknown. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441298PMC

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

Medchemcomm 2019 Mar 14;10(3):390-398. Epub 2019 Jan 14.

Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:

Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: (ConBr), (ConM), (DLasiL) and (DSclerL), and algae (AML), (BSL), (HML), (MEL) and (SfL). Read More

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http://dx.doi.org/10.1039/c8md00508gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430086PMC
March 2019
5 Reads

Acute encephalopathy associated with influenza infection: Case report and review of the literature.

Paediatr Child Health 2019 May 28;24(2):122-124. Epub 2018 Jun 28.

Departments of Pediatrics and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia.

Influenza has been associated with neurological complications. We describe the case of a toddler who presented with symptoms and signs of acute encephalopathy and hydrocephalus. Neuroimaging demonstrated cerebral edema and multifocal diffusion restriction in the thalamus and splenium of the corpus callosum. Read More

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http://dx.doi.org/10.1093/pch/pxy085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462119PMC

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification.

Nat Commun 2019 Apr 17;10(1):1799. Epub 2019 Apr 17.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Chemoenzymatic modification of cell-surface glycan structures has emerged as a complementary approach to metabolic oligosaccharide engineering. Here, we identify Pasteurella multocida α2-3-sialyltransferase M144D mutant, Photobacterium damsela α2-6-sialyltransferase, and Helicobacter mustelae α1-2-fucosyltransferase, as efficient tools for live-cell glycan modification. Combining these enzymes with Helicobacter pylori α1-3-fucosyltransferase, we develop a host-cell-based assay to probe glycan-mediated influenza A virus (IAV) infection including wild-type and mutant strains of H1N1 and H3N2 subtypes. Read More

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http://www.nature.com/articles/s41467-019-09608-w
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http://dx.doi.org/10.1038/s41467-019-09608-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470217PMC
April 2019
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10.742 Impact Factor

Influenza Follicles.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Medicine, Saiseikai Fukuoka General Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2573-18DOI Listing

Phosphoproteome analysis of cells infected with adapted and non-adapted influenza A virus reveals novel pro- and antiviral signaling networks.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, 35392 Giessen (Germany), Member of the German Center for Lung Research

Influenza A viruses (IAVs) quickly adapt to new environments and are well known to cross species barriers. To reveal a molecular basis for these phenomena, we compared the Ser/Thr and Tyr phosphoproteomes of murine lung epithelial cells early and late after infection with mouse-adapted SC35M virus or its non-adapted SC35 counterpart. With this analysis we identified a large set of upregulated Ser/Thr phosphorylations common to both viral genotypes, while Tyr phosphorylations showed little overlap. Read More

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http://dx.doi.org/10.1128/JVI.00528-19DOI Listing

A genome-wide haploid genetic screen identifies heparan sulfate-associated genes and the macropinocytosis modulator TMED10 as factors supporting vaccinia virus infection.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

Vaccinia virus is a promising viral vaccine and gene delivery candidate, and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-wide insertional mutagenesis approach in human haploid cells to identify host factors crucial for vaccinia virus infection. A library of mutagenized HAP1 cells was exposed to Modified Vaccinia Virus Ankara (MVA). Read More

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http://dx.doi.org/10.1128/JVI.02160-18DOI Listing

Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi, United States

Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, and mink) are well documented. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00282-19
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http://dx.doi.org/10.1128/JVI.00282-19DOI Listing
April 2019
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Fundamental contribution and host range determination of ANP32A and ANP32B in influenza A virus polymerase activity.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150069, China

The polymerase of the influenza virus is part of the key machinery necessary for viral replication. However, the avian influenza virus polymerase is restricted in mammalian cells. The cellular protein ANP32A has been recently found to interact with viral polymerase, and to both influence polymerase activity and interspecies restriction. Read More

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http://dx.doi.org/10.1128/JVI.00174-19DOI Listing
April 2019
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The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression.

Cell Rep 2019 Apr;27(3):776-792.e7

Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target selectivity during host shutoff remain poorly understood. Using transcriptome-wide and targeted reporter experiments, we demonstrate that the influenza A virus endoribonuclease PA-X usurps RNA splicing to selectively target host RNAs for destruction. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.063DOI Listing

Population dynamics at neuraminidase position 151 of influenza A (H1N1)pdm09 virus in clinical specimens.

J Gen Virol 2019 Apr 17. Epub 2019 Apr 17.

3​Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.

Influenza A virus mutates rapidly, allowing it to escape natural and vaccine-induced immunity. Neuraminidase (NA) is a surface protein capable of cleaving the glycosidic linkages of neuraminic acids to release newly formed virions from infected cells. Genetic variants within a viral population can influence the emergence of pandemic viruses as well as drug susceptibility and vaccine effectiveness. Read More

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http://dx.doi.org/10.1099/jgv.0.001258DOI Listing

Today's vaccination policies in Italy: The National Plan for Vaccine Prevention 2017-2019 and the Law 119/2017 on the mandatory vaccinations.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):54-64

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy.

The National Plan for Vaccine Prevention 2017-2019 has expanded the vaccination offer including new vaccines, enlarging the target population and introducing for the first time in Italy a life-course approach to vaccination. A "lifetime immunization schedule" is aimed to reduce the burden and the related costs of vaccine-preventable diseases through effective vaccination programs. However, to counteract the national steady downward trend in the uptake of vaccinations that caused a drop of the vaccination coverage below the 95% threshold to allow herd immunity, it was decided to make 10 vaccinations mandatory by the law 119/2017. Read More

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http://dx.doi.org/10.7416/ai.2019.2277DOI Listing
April 2019
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Evaluation of Vaccination Coverages in the Health Care Workers of a University Hospital in Southern Italy.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):13-24

Postgraduate Medical School in Hygiene and Preventive Medicine, University of Messina, Italy.

Introduction: An adequate immunization of the health care workers is essential for infection prevention and control, to avoid consequences not only for them, but for all patients that the health care workers could infect causing serious damage and / or death. Unfortunately, to date, despite the presence of international and national guidelines (Law Decree 119/2017), the vaccination coverage was low, also because of the "vaccine hesitancy" spread among the same health care workers. In light of the above, the aim of our study was to investigate the vaccination coverage of healthcare workers of all the operational units present in our hospital and to evaluate differences between sex, age, professional profile and area of work. Read More

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http://dx.doi.org/10.7416/ai.2019.2273DOI Listing

Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: ‎possible cohort effect following the 2009 influenza pandemic.

Euro Surveill 2019 Apr;24(15)

University of Toronto, Toronto, Canada.

IntroductionFindings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic.AimTo compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics in Canada.MethodsThe age distribution of unvaccinated influenza A(H1N1)pdm09 cases and test-negative controls were compared across A(H1N1)pdm09-dominant epidemics in 2018/19, 2015/16 and 2013/14 and with the general population of SPSN provinces. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104DOI Listing
April 2019
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Immunosuppressive potential of fowl adenovirus serotype 4.

Poult Sci 2019 Apr 16. Epub 2019 Apr 16.

College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong Province 271018, China.

Fowl adenovirus serotype 4 (FAdV-4) is the causative agent of hydropericardium syndrome. To clarify the effects of FAdV-4 on immune organs in birds, we conducted a detailed examination of dynamic morphology and damage mechanisms in chickens randomly divided into 4 groups (FAdV-4, vaccination, FAdV-4 plus vaccination, and control). FAdV-4 caused the depletion of lymphocytes and subsequent growth impairment in the thymus and bursa. Read More

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https://academic.oup.com/ps/advance-article/doi/10.3382/ps/p
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http://dx.doi.org/10.3382/ps/pez179DOI Listing
April 2019
2 Reads

Whole-genome Sequencing Provides Data for Stratifying Infection Prevention and Control Management of Nosocomial Influenza A.

Clin Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Division of Infection and Immunity, University College London, United Kingdom.

Background: Influenza A virus causes annual epidemics in humans and is associated with significant morbidity and mortality. Haemagglutinin (HA) and neuraminidase (NA) gene sequencing have traditionally been used to identify the virus genotype, although their utility in detecting outbreak clusters is still unclear. The objective of this study was to determine the utility, if any, of whole-genome sequencing over HA/NA sequencing for infection prevention and control (IPC) in hospitals. Read More

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http://dx.doi.org/10.1093/cid/ciz020DOI Listing

A pediatric case of acute neck swelling due to bilateral submandibular sialadenitis following influenza A infection.

IDCases 2019 12;15:e00517. Epub 2019 Mar 12.

Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

A 12-year-old boy presented with acute neck swelling diagnosed as submandibular sialadenitis secondary to influenza; it resolved quickly with supportive care. Recognition of this as a clinical entity during the influenza season may help guide management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509193000
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http://dx.doi.org/10.1016/j.idcr.2019.e00517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441735PMC
March 2019
1 Read