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    1 OF 1927

    Intramuscular and intranasal immunization with an H7N9 influenza virus-like particle vaccine protects mice against lethal influenza virus challenge.
    Int Immunopharmacol 2018 Mar 20;58:109-116. Epub 2018 Mar 20.
    Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130122, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225000, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address:
    The H7N9 influenza virus epidemic has been associated with a high mortality rate in China. Therefore, to prevent the H7N9 virus from causing further damage, developing a safe and effective vaccine is necessary. In this study, a vaccine candidate consisting of virus-like particles (VLPs) based on H7N9 A/Shanghai/2/2013 and containing hemagglutinin (HA), neuraminidase (NA), and matrix protein (M1) was successfully produced using a baculovirus (BV) expression system. Read More

    Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation.
    Mycoses 2018 Mar 23. Epub 2018 Mar 23.
    Department of Clinical Microbiology, Trinity College Dublin, Dublin 8, Ireland.
    Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. Additionally, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. Read More

    Avian viral surveillance in Victoria, Australia, and detection of two novel avian herpesviruses.
    PLoS One 2018 23;13(3):e0194457. Epub 2018 Mar 23.
    Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.
    Viruses in avian hosts can pose threats to avian health and some have zoonotic potential. Hospitals that provide veterinary care for avian patients may serve as a site of exposure of other birds and human staff in the facility to these viruses. They can also provide a useful location to collect samples from avian patients in order to examine the viruses present in wild birds. Read More

    Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways.
    Int J Mol Sci 2018 Mar 23;19(4). Epub 2018 Mar 23.
    Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515041, China.
    Oxymatrine (OMT) is a strong immunosuppressive agent that has been used in the clinic for many years. In the present study, by using plaque inhibition, luciferase reporter plasmids, qRT-PCR, western blotting, and ELISA assays, we have investigated the effect and mechanism of OMT on influenza A virus (IAV) replication and IAV-induced inflammation in vitro and in vivo. The results showed that OMT had excellent anti-IAV activity on eight IAV strains in vitro. Read More

    Eliciting unnatural immune responses by activating cryptic epitopes in viral antigens.
    FASEB J 2018 Mar 23:fj201701024RRR. Epub 2018 Mar 23.
    Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.
    Antigenic variation in viral surface antigens is a strategy for escaping the host's adaptive immunity, whereas regions with pivotal functions for infection are less subject to antigenic variability. We hypothesized that genetically invariable and immunologically dormant regions of a viral surface antigen could be exposed to the host immune system and activated by rendering them susceptible to antigen-processing machinery in professional antigen-presenting cells (APCs). Considering the frequent antigen drift and shift in influenza viruses, we identified and used structural modeling to evaluate the conserved regions on the influenza hemagglutinin (HA) surface as potential epitopes. Read More

    Pharmacist Views on Alternative Methods for Antiviral Distribution and Dispensing During an Influenza Pandemic.
    Health Secur 2018 Mar 23. Epub 2018 Mar 23.
    Antiviral drugs are likely to be a frontline countermeasure needed to minimize disease impact during an influenza pandemic. As part of pandemic influenza preparedness efforts, the Centers for Disease Control and Prevention, in coordination with state health departments, has plans in place to distribute and dispense antiviral drugs from public stockpiles. These plans are currently under review and include evaluation of the benefits of commercial distribution and dispensing through community pharmacies. Read More

    Simulation of key interventions for seasonal influenza outbreak control at school in Changsha, China.
    J Int Med Res 2018 Jan 1:300060518764268. Epub 2018 Jan 1.
    1 Changsha Centre for Disease Control and Prevention, Changsha, Hunan Province, China.
    Objective To use a mathematical model to simulate an influenza outbreak in a school in order to assess the effectiveness of isolation (Iso), antiviral therapeutics, antiviral prophylactics (P), vaccination prior to the outbreak, and school closure (for 1 [S1w], 2 or 3 weeks). Methods This study developed a susceptible-exposed-infectious/asymptomatic-recovered model to estimate the effectiveness of commonly used interventions for seasonal influenza outbreaks in school. Results The most effective single-intervention strategy was isolation with a total attack rate of 1. Read More

    Highly Sensitive and Automated SERS-based Immunoassay for H5N1 Detection with Digital Microfluidics.
    Anal Chem 2018 Mar 23. Epub 2018 Mar 23.
    Digital microfluidics (DMF) is a powerful platform for a broad range of applications, especially immunoassays having multiple steps, due to the advantages of low reagent consumption and high automatization. Surface Enhanced Raman Scattering (SERS) has been proven as an attractive method for highly sensitive and multiplex detection, because of its remarkable signal amplification and excellent spatial resolution. Here we propose a SERS-based immunoassay with DMF for rapid, automated and sensitive detection of disease biomarkers. Read More

    Educating children and adolescents about vaccines: A review of current literature.
    Expert Rev Vaccines 2018 Mar 23. Epub 2018 Mar 23.
    e Institut national de santé publique du Québec , Québec , QC.
    Introduction: Until recently, research on vaccine hesitancy has focused primarily on parent populations. Although adolescent knowledge and views are gaining momentum within the literature, particularly as they pertain to the Human Papillomavirus and influenza, children remain a virtually unstudied population with regards to vaccine hesitancy. Areas Covered: This review focuses on the lack of literature in this area and argues for more vaccine hesitancy research involving child and adolescent populations. Read More

    A New Approach to Evaluating the Risk-Benefit Equation for Dual-Use and Gain-of-Function Research of Concern.
    Front Bioeng Biotechnol 2018 8;6:21. Epub 2018 Mar 8.
    Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, United States.
    In the twenty-first century, biology faces a problem that has previously vexed other disciplines such as physics, namely the prospect that its knowledge domain could be used to generate biological agents with altered properties that enhanced their weapon potential. Biological weapons bring the additional dimension that these could be self-replicating, easy to manufacture and synthesized with commonly available expertise. This resulted in increasing concern about the type of research done and communicated, despite the fact that such research often has direct societal benefits, bringing the dual-use dilemma to biology. Read More

    Linking influenza epidemic onsets to covariates at different scales using a dynamical model.
    PeerJ 2018 8;6:e4440. Epub 2018 Mar 8.
    Laboratoire de Biométrie et Biologie Evolutive URM5558-CNRS, Université de Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
    Background: Evaluating the factors favoring the onset of influenza epidemics is a critical public health issue for surveillance, prevention and control. While past outbreaks provide important insights for understanding epidemic onsets, their statistical analysis is challenging since the impact of a factor can be viewed at different scales. Indeed, the same factor can explain why epidemics are more likely to begin (i) during particular weeks of the year (global scale); (ii) earlier in particular regions (spatial scale) or years (annual scale) than others and (iii) earlier in some years than others within a region (spatiotemporal scale). Read More

    Complete Genomic Sequences of H3N8 Equine Influenza Virus Strains Used as Vaccine Strains in Japan.
    Genome Announc 2018 Mar 22;6(12). Epub 2018 Mar 22.
    Equine Research Institute, Japan Racing Association, Tochigi, Japan.
    We sequenced the eight segments of influenza A virus strains A/equine/Ibaraki/1/2007 and A/equine/Yokohama/aq13/2010, which are strains of the Florida sublineage clades 1 and 2 of the H3N8 subtype equine influenza virus. These strains have been used as vaccine strains in Japan since 2016 in accordance with World Organization for Animal Health (OIE) recommendations. Read More

    PrEP-001 prophylactic effect against rhinovirus and influenza virus - RESULTS of 2 randomized trials.
    Antiviral Res 2018 Mar 19. Epub 2018 Mar 19.
    Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
    Background: PrEP-001 Nasal Powder, a proprietary formulation of polyriboinosinic and polyribocytidylic acid effectively elicits a cellular innate immune response in nasal epithelium. The aim of these 2 studies was to investigate the safety and efficacy of PrEP-001 prophylaxis against rhinovirus (HRV-A16) and influenza-A (H3N2-IAV).

    Methods: Healthy subjects randomly received 2 doses of PrEP-001 or placebo, 48 and 24 h pre-challenge with 10 TCIDof HRV-A16 (Study 1) or H3N2-IAV (Study 2). Read More

    Sialyllactose-modified 3-way junction DNA as binding inhibitor of influenza virus hemagglutinin.
    Bioconjug Chem 2018 Mar 22. Epub 2018 Mar 22.
    Sialic acid present on the cell surface is recognized by hemagglutinin (HA) on the influenza virus in the first step of infection. Therefore, a compound that can efficiently interfere with the interaction between sialic acid and HA might inhibit infection and allow detection of the influenza virus. We focused on the spatial arrangement of sialic acid binding sites on HA and developed 2,3-sialyllactose (2,3-SL)-modified 3-way junction (3WJ) DNA molecules with a topology similar to that of sialic acid binding sites. Read More

    Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI).
    PLoS One 2018 22;13(3):e0194180. Epub 2018 Mar 22.
    Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    Background: The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza.

    Objectives: This study tested the reliability, validity, and responsiveness of FLU-PRO scores in adults with influenza-like illness (ILI).

    Methods: Data from the prospective, observational study used to develop and test the FLU-PRO in influenza virus positive patients were analyzed. Read More

    Patient's behaviors and missed opportunities for vaccination against seasonal epidemic influenza and evaluation of their impact on patient's influenza vaccine uptake.
    PLoS One 2018 22;13(3):e0193029. Epub 2018 Mar 22.
    Emergency Department, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
    Objectives: Influenza vaccination (IV) coverage remains low in France. Objectives were to assess patient knowledge and behaviors and missed opportunities for vaccination (MO) and their impact on vaccine uptake.

    Methods: This is a prospective-observational study, including emergency department patients at risk for severe influenza. Read More

    Initial Public Health Laboratory Response After Hurricane Maria - Puerto Rico, 2017.
    MMWR Morb Mortal Wkly Rep 2018 Mar 23;67(11):333-336. Epub 2018 Mar 23.
    Hurricane Maria made landfall in Puerto Rico on September 20, 2017, causing major damage to infrastructure and severely limiting access to potable water, electric power, transportation, and communications. Public services that were affected included operations of the Puerto Rico Department of Health (PRDOH), which provides critical laboratory testing and surveillance for diseases and other health hazards. PRDOH requested assistance from CDC for the restoration of laboratory infrastructure, surveillance capacity, and diagnostic testing for selected priority diseases, including influenza, rabies, leptospirosis, salmonellosis, and tuberculosis. Read More

    Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines.
    Funct Integr Genomics 2018 Mar 21. Epub 2018 Mar 21.
    Schoolof Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
    Host genetic factors play an important role in diverse host outcomes after influenza A (H7N9) infection. Studying differential responses of inbred mouse lines with distinct genetic backgrounds to influenza virus infection could substantially increase our understanding of the contributory roles of host genetic factors to disease severity. Here, we utilized an integrated approach of mRNA-seq and miRNA-seq to investigate the transcriptome expression and regulation of host genes in C57BL/6J and DBA/2J mouse strains during influenza virus infection. Read More

    IRF4 Modulates CD8T Cell Sensitivity to IL-2 Family Cytokines.
    Immunohorizons 2017 Aug 14;1(6):92-100. Epub 2017 Aug 14.
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905.
    IFN regulatory factor 4 (IRF4) is a key transcription factor that promotes effector CD8T cell differentiation and expansion. The roles of IRF4 in regulating the CD8T cell response to cytokines have not been explored. In this article, we show that IL-2 and IL-15 signaling and STAT5 activation regulate IRF4 expression in CD8T cells. Read More

    Acute Epiglottitis in the Immunocompromised Host: Case Report and Review of the Literature.
    Open Forum Infect Dis 2018 Mar 17;5(3):ofy038. Epub 2018 Feb 17.
    Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryl.
    We present a case of acute epiglottitis in a 16-year-old with severe aplastic anemia. He was admitted with a history suggestive of a severe upper airway infection and an absolute neutrophil count of 0 per cubic millimeter. Despite his immunocompromised state, he presented with the classical signs and symptoms of epiglottitis. Read More

    An infant presenting with Kawasaki disease following immunization for influenza: A case report.
    Biomed Rep 2018 Mar 16;8(3):301-303. Epub 2018 Jan 16.
    Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Republic of Korea.
    Kawasaki disease (KD) is a childhood vascular disorder of unknown etiology. Concerns have recently been raised regarding vaccinations as a potential risk factor for KD. In addition, various forms of vasculitis have been reported as adverse events following administration after various vaccines. Read More

    Atypical Optic Neuritis After Inactivated Influenza Vaccination.
    Neuroophthalmology 2018 Apr 17;42(2):105-108. Epub 2017 Aug 17.
    Mason Eye Institute, Department of Ophthalmology, University of Missouri School of Medicine, Columbia, Missouri, USA.
    The existence of vaccine-associated optic neuritis is essentially based on the temporal relationship between the administration of a vaccine and the development of optic neuritis in patients with no other known aetiologies for infectious or non-infectious inflammation that could account for the optic neuritis. Influenza vaccine (inactivated or live attenuated) is considered to be one of vaccines that could be related to optic neuritis. The authors describe a rare case of bilateral asymmetric optic neuritis with leptomeningeal enhancement on magnetic resonance imaging (MRI) in a previously healthy young woman who received inactivated influenza vaccination 2 weeks before the onset of symptoms. Read More

    Health-seeking behavior and transmission dynamics in the control of influenza infection among different age groups.
    Infect Drug Resist 2018 6;11:331-343. Epub 2018 Mar 6.
    Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan, Republic of China.
    Background: It has been found that health-seeking behavior has a certain impact on influenza infection. However, behaviors with/without risk perception on the control of influenza transmission among age groups have not been well quantified.

    Objectives: The purpose of this study was to assess to what extent, under scenarios of with/without control and preventive/protective behaviors, the age-specific network-driven risk perception influences influenza infection. Read More

    New threats of H7N9 influenza virus: the spread and evolution of highly and low pathogenic variants with high genomic diversity in Wave Five.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China
    H7N9 virus has caused five infection waves since it emerged in 2013. The highest number of human cases was seen in Wave Five; however, the underlying reasons have not been thoroughly elucidated. In this study, the geographical distribution, phylogeny and genetic evolution of 240 H7N9 viruses in Wave Five, including 35 new isolates from patients and poultry in nine provinces, were comprehensively analyzed together with strains from first four waves. Read More

    Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Viral infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
    Transmission of avian influenza (AI) viruses to mammals involves phylogenetic bottlenecks that select small numbers of variants for transmission to new host species. However, little is known about the AI virus quasispecies diversity that produces variants for virus adaptation to humans. Here, we analyzed the hemagglutinin (HA) genetic diversity produced during AI H5N1 single-virus infection of primary human airway cells and characterized the phenotypes of these variants. Read More

    Activation and induction of antigen-specific T follicular helper cells (T) play a critical role in LAIV-induced human mucosal anti-influenza antibody response.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, UK
    There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. Antibody response is critical in vaccine-induced protection and Tis considered important in mediating antibody response. Most data supporting the role for Tin antibody response are from animal studies, and direct evidence from humans is limited, apart from T-like cells in blood. Read More

    A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, PR China
    Nonstructural protein 1 (NS1) of influenza A virus regulates innate immune responses via various mechanisms. We previously showed that a naturally occurring deletion (the EALQR motif) in the NS1 effector domain of an H5N1 swine-origin avian influenza virus impairs the inhibition of type I interferon (IFN) in chicken fibroblasts and attenuates virulence in chickens. Here, we found that the virus bearing this deletion in its NS1 effector domain showed diminished inhibition of IFN-related cytokine expression and attenuated virulence in mice. Read More

    H5N1 influenza A virus PB1-F2 relieves HAX-1-mediated restriction of avian virus polymerase PA in human lung cells.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Switzerland
    Highly pathogenic IAV from avian hosts were first reported to directly infect humans 20 years ago. However, these are rare events and our understanding of factors promoting or restricting zoonotic transmission is still limited. One accessory protein of IAV, PB1-F2, was associated with pathogenicity of pandemic and zoonotic IAV. Read More

    Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland.
    Eur Respir J 2018 Mar 21. Epub 2018 Mar 21.
    Institute of Health Informatics, UCL, London, UK.
    While acute respiratory infections can trigger cardiovascular events, the differential effect of specific organisms is unknown. This is important to guide vaccine policy.Using national infection surveillance data linked to the Scottish Morbidity Record, we identified adults with a first myocardial infarction (MI) or stroke from 01/01/2004 to 31/12/2014 and a record of laboratory-confirmed respiratory infection during this period. Read More

    A Participatory System for Preventing Pandemics of Animal Origins: Pilot Study of the Participatory One Health Disease Detection (PODD) System.
    JMIR Public Health Surveill 2018 Mar 21;4(1):e25. Epub 2018 Mar 21.
    Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Background: Aiming for early disease detection and prompt outbreak control, digital technology with a participatory One Health approach was used to create a novel disease surveillance system called Participatory One Health Disease Detection (PODD). PODD is a community-owned surveillance system that collects data from volunteer reporters; identifies disease outbreak automatically; and notifies the local governments (LGs), surrounding villages, and relevant authorities. This system provides a direct and immediate benefit to the communities by empowering them to protect themselves. Read More

    Predicting risk of avian influenza a(H5N1) in Egypt: the creation of a community level metric.
    BMC Public Health 2018 Mar 21;18(1):388. Epub 2018 Mar 21.
    School of Veterinary Sciences, University of Bristol, Bristol, UK.
    Background: Efficient A(H5N1) control is unlikely to be based on epidemiological data alone. Such control depends on a thorough understanding and appreciation of the interconnectedness of epidemiological, social, and economic factors that contribute to A(H5N1) vulnerability. To date, the control of A(H5N1) in Egypt has been challenging. Read More

    Nucleosides for the treatment of respiratory RNA virus infections.
    Antivir Chem Chemother 2018 Jan-Dec;26:2040206618764483
    333755 Alios BioPharma, Inc. , a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, USA.
    Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds. These RNA viruses can also cause lower respiratory tract infections leading to bronchiolitis and pneumonia. Young children, the elderly, and patients with compromised cardiac, pulmonary, or immune systems are at greatest risk for serious disease associated with these RNA virus respiratory infections. Read More

    Role of genetic heterogeneity in determining the epidemiological severity of H1N1 influenza.
    PLoS Comput Biol 2018 Mar 21;14(3):e1006069. Epub 2018 Mar 21.
    IISc Mathematics Initiative, Indian Institute of Science, Bangalore, Karnataka, India.
    Genetic differences contribute to variations in the immune response mounted by different individuals to a pathogen. Such differential response can influence the spread of infectious disease, indicating why such diseases impact some populations more than others. Here, we study the impact of population-level genetic heterogeneity on the epidemic spread of different strains of H1N1 influenza. Read More

    Comparison of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome.
    Medicine (Baltimore) 2018 Mar;97(12):e0194
    Department of Respiratory Intensive Care Unit.
    The aim of this study was to compare the clinical features of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome (ARDS).The clinical data of 18 cases of H7N9 and 26 cases of H1N1 with ARDS were collected and compared in the respiratory intensive care unit (RICU) of Fuzhou Pulmonary Hospital of Fujian from March 2014 to December 2016.Patients with H7N9 had a higher acute physiology and chronic health evaluation-II score (P < . Read More

    Immunogenicity of simultaneous versus sequential administration of a 23-valent pneumococcal polysaccharide vaccine and a quadrivalent influenza vaccine in older individuals: A randomized, open-label, non-inferiority trial.
    Hum Vaccin Immunother 2018 Mar 21. Epub 2018 Mar 21.
    f Department of Laboratory Medicine , Kameda Medical Center, 929 Higashi-cho, Kamogawa , Chiba 296-8602, Japan.
    It is unclear whether simultaneous administration of a 23-valent pneumococcal polysaccharide vaccine (PPSV23) and a quadrivalent influenza vaccine (QIV) produces immunogenicity in older individuals. This study tested the hypothesis that the pneumococcal antibody response elicited by simultaneous administration of PPSV23 and QIV in older individuals is not inferior to that elicited by sequential administration of PPSV23 and QIV. We performed a single-center, randomized, open-label, non-inferiority trial comprising 162 adults aged ≥65 years randomly assigned to either the simultaneous (simultaneous injections of PPSV23 and QIV) or sequential (control; PPSV23 injected 2 weeks after QIV vaccination) groups. Read More

    Vaccination post-allogeneic hematopoietic stem cell transplantation: what is feasible?
    Expert Rev Vaccines 2018 Mar 21:1-11. Epub 2018 Mar 21.
    a Département de Maladies infectieuses et tropicales , Hospices Civils de Lyon , Lyon , France.
    Introduction: Allogeneic hematopoietic stem cell transplantation (HSCT) is a major curative treatment option for malignant and non-malignant hematological diseases, but is associated with an increased risk for infections, of which some are preventable by vaccination. Vaccination guidelines recommend repeated doses of most inactivated vaccines to achieve long-lasting immune responses. However, the efficacy of immunization is often hampered by graft-versus-host disease or severe opportunistic infections. Read More

    Moving epidemic method (MEM) applied to virology data as a novel real time tool to predict peak in seasonal influenza healthcare utilisation. The Scottish experience of the 2017/18 season to date.
    Euro Surveill 2018 Mar;23(11)
    Health Protection Scotland (HPS), Glasgow, United Kingdom.
    Scotland observed an unusual influenza A(H3N2)-dominated 2017/18 influenza season with healthcare services under significant pressure. We report the application of the moving epidemic method (MEM) to virology data as a tool to predict the influenza peak activity period and peak week of swab positivity in the current season. This novel MEM application has been successful locally and is believed to be of potential use to other countries for healthcare planning and building wider community resilience. Read More

    Risk of bias and limits of reporting in diagnostic accuracy studies for commercial point-of-care tests for respiratory pathogens.
    Epidemiol Infect 2018 Mar 21:1-10. Epub 2018 Mar 21.
    Faculty of Medicine,Memorial University of Newfoundland,St. John's, NL,Canada.
    Commercial point-of-care (POC) diagnostic tests for Group A Streptococcus, Streptococcus pneumoniae, and influenza virus have large potential diagnostic and financial impact. Many published reports on test performance, often funded by diagnostics companies, are prone to bias. The Standards for Reporting of Diagnostic Accuracy (STARD 2015) are a protocol to encourage accurate, transparent reporting. Read More

    Frequency and Factors Associated with Adult Immunization in Patients Visiting Family Medicine Clinics at a Tertiary Care Hospital, Karachi.
    Cureus 2018 Jan 17;10(1):e2083. Epub 2018 Jan 17.
    Family Medicine, The Aga Khan University.
    Objective The goal of this study was to determine the frequency and factors associated with adult immunization in patients visiting family medicine clinics at a tertiary care hospital in Karachi. Methods A cross-sectional study was conducted from March 2014 to March 2015 in a tertiary care hospital in Karachi, Pakistan. Participants more than 18 years were invited to participate in the study. Read More

    First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL.
    Oncotarget 2018 Feb 22;9(16):13023-13035. Epub 2018 Jan 22.
    Blood Cancer Research Program, Sarah Cannon Research Institute, Nashville, TN, USA.
    GDC-0853 is a selective, reversible, and non-covalent inhibitor of Bruton's tyrosine kinase (BTK) that does not require interaction with the Cys481 residue for activity. In this first-in-human phase 1 study we evaluated safety, tolerability, pharmacokinetics, and activity of GDC-0853 in patients with relapsed or refractory non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL). Twenty-four patients, enrolled into 3 cohorts, including 6 patients who were positive for the C481S mutation, received GDC-0853 at 100, 200, or 400 mg once daily, orally. Read More

    Prediction of influenza-like illness based on the improved artificial tree algorithm and artificial neural network.
    Sci Rep 2018 Mar 20;8(1):4895. Epub 2018 Mar 20.
    School of Science, North University of China, Taiyuan, Shanxi, 030051, PR China.
    Because influenza is a contagious respiratory illness that seriously threatens public health, accurate real-time prediction of influenza outbreaks may help save lives. In this paper, we use the Twitter data set and the United States Centers for Disease Control's influenza-like illness (ILI) data set to predict a nearly real-time regional unweighted percentage ILI in the United States by use of an artificial neural network optimized by the improved artificial tree algorithm. The results show that the proposed method is an efficient approach to real-time prediction. Read More

    Acute Exudative Polymorphous Vitelliform Maculopathy Syndrome; natural history and evolution of fundal and OCT images over time.
    BMJ Case Rep 2018 Mar 20;2018. Epub 2018 Mar 20.
    Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.
    A 33-year-old man presented with a 10-day history of bilateral blurred vision on a background of a prodromal influenza-like illness. Ocular Coherence Tomography (OCT) and fundal examination coincided with a diagnosis of atypical central serous retinopathy. The patient's symptoms worsened during follow-up, and he was started on steroids. Read More

    Patients with influenza A (H1N1)pdm09 admitted to the ICU. Impact of the recommendations of the SEMICYUC.
    Med Intensiva 2018 Mar 17. Epub 2018 Mar 17.
    Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; Grupo de Investigación en Patología Crítica (GREPAC), Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, España; Universitat Autònoma de Barcelona, Barcelona, España.
    Objectives: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A.

    Design: A prospective multicenter observational study was carried out.

    Setting: ICU. Read More

    Global spatial risk pattern of highly pathogenic avian influenza H5N1 virus in wild birds: A knowledge-fusion based approach.
    Prev Vet Med 2018 Apr 12;152:32-39. Epub 2018 Feb 12.
    Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai 200032, China; Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China; Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health, Fudan University, China. Electronic address:
    Highly pathogenic avian influenza (HPAI) H5N1 viruses have continuously circulated throughout much of the world since 2003, resulting in huge economic losses and major public health problems. Wild birds have played an important role in the spread of H5N1 HPAI. To understand its spatial distribution, H5N1 HPAI have been studied by many disciplines from different perspectives, but only one kind of disciplinary knowledge was involved, which has provided limited progress in understanding. Read More

    BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data.
    Genome Med 2018 Mar 20;10(1):20. Epub 2018 Mar 20.
    Division of Microbiology and Immunology, Yerkes National Primate Research Center, Atlanta, GA, USA.
    B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline, BALDR (BCR Assignment of Lineage using De novo Reconstruction) that accurately reconstructs the paired heavy and light chain immunoglobulin gene sequences from Illumina single-cell RNA-seq data. BALDR was accurate for clonotype identification in human and rhesus macaque influenza vaccine and simian immunodeficiency virus vaccine induced vaccine-induced plasmablasts and naïve and antigen-specific memory B cells. Read More

    Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines.
    BMC Complement Altern Med 2018 Mar 20;18(1):102. Epub 2018 Mar 20.
    Beijing Key Laboratory of Drug Target Research and Drug Screening, Institute of Material Medica, Chinese Academy Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Xicheng District, Beijing, 100050, People's Republic of China.
    Background: Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts from some medicinal plants traditionally used in Lingnan Chinese Medicines by NA activity high-throughput screening assay.

    Methods: One hundred ninety herbal extracts from 95 medicinal plants collected in Guangzhou were screened for their potential inhibitory activities against A (H1N1) influenza neuraminidase, and the most active extracts were further evaluated for their anti-influenza virus activities using virus-induced cytopathic effect (CPE). Read More

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