114,889 results match your criteria Influenza


Preparation and evaluation of virus-like particle vaccine against H3N8 subtype equine influenza.

Microb Pathog 2021 May 12:104885. Epub 2021 May 12.

Laboratory of Infectious Diseases, College of Veterinary Medicine, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun, 130062, China. Electronic address:

To prevent and control H3N8 subtype equine influenza, we prepared virus-like particles (VLPs) comprising the HA, NA and M1 proteins of H3N8 equine influenza virus (EIV) through the insect cell-baculovirus expression system. The results of Western blot and hemagglutination analyses demonstrated that the constructed VLPs comprising HA, NA and M1 proteins have good hemagglutination activity. Immunoelectron microscope revealed that the VLPs share similar morphology and structure with natural virus particles. Read More

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

Dermatologikum, Hamburg, Germany.

Background: Fumaric acid esters (FAEs; Fumaderm ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi ) is a humanized IgG1 monoclonal antibody that specifically binds to the p19 subunit of interleukin-23.

Objective: This study compared risankizumab treatment with FAEs in psoriasis patients. Read More

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Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a.

Cell Death Differ 2021 May 14. Epub 2021 May 14.

Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.

Accumulating evidence has shown that long noncoding RNAs (lncRNAs) are involved in several biological processes, including immune responses. However, the role of lncRNAs in antiviral innate immune responses remains largely elusive. Here, we identify an uncharacterized human lncRNA AVAN from influenza A virus (IAV) infected patients, that is significantly upregulated following RNA virus infection. Read More

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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.

Sci Immunol 2021 May;6(59)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Inflammatory diseases are frequently treated with Janus kinase (JAK) inhibitors to diminish cytokine signaling. These treatments can lead to inadvertent immune suppression and may increase the risk of viral infection. Tyrosine kinase 2 (TYK2) is a JAK family member required for efficient type I interferon (IFN-α/β) signaling. Read More

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Uptake of influenza vaccination among persons with inflammatory bowel disease, multiple sclerosis or rheumatoid arthritis: a population-based matched cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E510-E521. Epub 2021 May 14.

Department of Internal Medicine (Marrie, Hitchon, Marriott, Bernstein), Department of Community Health Sciences (Marrie, Lix, Katz), Manitoba Centre for Health Policy (Walld, Katz), Department of Psychiatry (Bolton, Sareen), Department of Family Medicine (Singer, Katz), Department of Clinical Health Psychology (El-Gabalawy) and Department of Anesthesiology and Perioperative and Pain Medicine (El-Gabalawy), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Man.; Department of Community Health Sciences (Patten), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Departments of Psychiatry (Fisk), of Psychology and Neuroscience (Fisk) and of Medicine (Fisk), Dalhousie University, Halifax, NS.

Background: Individuals with immune-mediated inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, are at increased risk for influenza and related complications. We examined and compared the uptake of influenza vaccination among people with and without these diseases, as well as the influence of psychiatric comorbidity on vaccine uptake.

Methods: Using administrative data from Apr. Read More

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Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study.

Eur J Med Res 2021 May 14;26(1):45. Epub 2021 May 14.

Research Center of Clinical and Translational Medicine, Fifth Medical Center of Chinese, PLA General Hospital, 100 Middle Street of 4th West Ring Road, Beijing, 100039, China.

Background: Hematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment.

Methods: In this retrospective case-control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020].

Results: One of the COVID-19 characteristics was a continuous decline in the hemoglobin level. Read More

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Moderately pathogenic maternal influenza A virus infection disrupts placental integrity but spares the fetal brain.

Brain Behav Immun 2021 May 11. Epub 2021 May 11.

Institute for Behavioral Medicine Research, The Ohio State University, Columbus OH USA; Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus OH USA; Infectious Diseases Institute, The Ohio State University, Columbus, OH USA; Medical Scientist Training Program, The Ohio State University, Columbus OH USA; Department of Neuroscience, The Ohio State University, Columbus OH USA; Department of Obstetrics & Gynecology, The Ohio State University, Columbus OH USA. Electronic address:

Maternal infection during pregnancy is a known risk factor for offspring mental health disorders. Animal models of maternal immune activation (MIA) have implicated specific cellular and molecular etiologies of psychiatric illness, but most rely on pathogen mimetics. Here, we developed a mouse model of live H3N2 influenza A virus (IAV) infection during pregnancy that induces a robust inflammatory response but is sublethal to both dams and offspring. Read More

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Revisión rápida: probabilidad de contagio por infecciones respiratorias agudas en el transporte público colectivo.

Salud Publica Mex 2021 Feb 26;63(2, Mar-Abr):225-231. Epub 2021 Feb 26.

Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México..

Objetivo. Determinar el nivel de evidencia sobre la proba-bilidad de transmisión de enfermedades respiratorias agudas en el transporte público colectivo. Material y métodos. Read More

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February 2021

Graphene Oxide Nanosheets Interact and Interfere with SARS-CoV-2 Surface Proteins and Cell Receptors to Inhibit Infectivity.

Small 2021 May 14:e2101483. Epub 2021 May 14.

Stem Cell Institute, Ankara University, Balgat, Ankara, 06520, Turkey.

Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID-19) acting both extracellularly and intracellularly to the host cells. Here, the aim is to explore graphene oxide (GO), the most studied 2D nanomaterial in biomedical applications, as a nanoscale platform for interaction with SARS-CoV-2. Molecular docking analyses of GO sheets on interaction with three different structures: SARS-CoV-2 viral spike (open state - 6VYB or closed state - 6VXX), ACE2 (1R42), and the ACE2-bound spike complex (6M0J) are performed. Read More

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Public awareness, attitudes, beliefs, and behaviors regarding the role of pharmacists as immunizers.

Hum Vaccin Immunother 2021 May 14:1-14. Epub 2021 May 14.

Canadian Center for Vaccinology, Dalhousie University, IWK Health and Nova Scotia Health, Halifax, NS, Canada.

Vaccine coverage is below desired levels in Canada, despite National Advisory Committee on Immunization recommendations. One solution to improve coverage is to offer vaccines in pharmacies. We explore the awareness, attitudes, beliefs, and behaviors of the general public in four communities in Nova Scotia (NS) and New Brunswick (NB) about the changing role of pharmacists as immunizers. Read More

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An Open-Label Randomized Controlled Parallel-Group Pilot Study Comparing the Immunogenicity of a Standard-, Double- And Booster-Dose Regimens of the 2014 Seasonal Trivalent Inactivated Influenza Vaccine In Kidney Transplant Recipients.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1. Departamento de Moléstias Infecciosas, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil. 2. Instituto Butantan, Divisão de Ensaios Clínicos, São Paulo, Brasil. 3. Serviço de Biologia Molecular da Divisão de Laboratório Central, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil. 4. Instituto Adolfo Lutz, Centro de Virologia, São Paulo, Brasil. 5. Serviço de Transplante Renal, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brasil.

Background: Immunogenicity of influenza vaccine in transplant recipients is suboptimal and alternative vaccination regimens are necessary.

Methods: We compared the immunogenicity of a standard-dose trivalent inactivated influenza vaccination (SDTIIV), double-dose trivalent inactivated influenza vaccination (DDTIIV) and booster-dose trivalent inactivated influenza vaccination (BDTIIV) of the 2014 seasonal trivalent inactivated influenza vaccine in kidney transplant recipients. We randomized 176 participants to SDTIIV (59), DDTIIV (59) and BDTIIV regimens (58). Read More

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February 2021

Exposure of wild boar to Influenza A viruses in Bavaria: Analysis of seroprevalences and antibody subtype specificity before and after the panzootic of highly pathogenic avian influenza viruses A (H5N8).

Zoonoses Public Health 2021 May 13. Epub 2021 May 13.

Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.

Swine influenza A viruses (S-IAV) circulate in wild boar populations worldwide. Subtypes primarily reflect those actually present within the respective pig industry. Accordingly, infections with swine H1N1, H1N2 and H3N2 have been reported for several regions of Germany. Read More

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Changing attitudes towards annual influenza vaccination amongst staff in a Tertiary Care Irish University Hospital.

Ir J Med Sci 2021 May 13. Epub 2021 May 13.

Department of Infectious Diseases, St. Vincent's University Hospital, Dublin, Ireland.

Background: Healthcare workers are encouraged annually to get vaccinated against influenza. This year in view of COVID-19 pandemic, attitudes of HCWs towards vaccination are particularly important. A cross-sectional study was completed to understand how to best encourage and facilitate the vaccination of HCWs based on the previous years' findings. Read More

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In silico design of a multi-epitope peptide construct as a potential vaccine candidate for Influenza A based on neuraminidase protein.

In Silico Pharmacol 2021 11;9(1):36. Epub 2021 May 11.

Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Designing an effective vaccine against different subtypes of Influenza A virus is a critical issue in the field of medical biotechnology. At the current study, a novel potential multi-epitope vaccine candidate based on the neuraminidase proteins for seven subtypes of Influenza virus was designed, using the in silico approach. Potential linear B-cell and T-cell binding epitopes from each neuraminidase protein (N1, N2, N3, N4, N6, N7, N8) were predicted by in silico tools of epitope prediction. Read More

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Fast prototyping of a local fuzzy search system for decision support and retraining of hospital staff during pandemic.

Health Inf Sci Syst 2021 Dec 11;9(1):21. Epub 2021 May 11.

Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg, 197022 Russia.

Purpose: The COVID-19 pandemic showed an urgent need for decision support systems to help doctors at a time of stress and uncertainty. However, significant differences in hospital conditions, as well as skepticism of doctors about machine learning algorithms, limit their introduction into clinical practice. Our goal was to test and apply the principle of "patient-like-mine" decision support in rapidly changing conditions of a pandemic. Read More

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December 2021

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.

Front Immunol 2021 27;12:618332. Epub 2021 Apr 27.

Laboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes. Read More

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IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.

Nat Microbiol 2021 May 13. Epub 2021 May 13.

Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.

The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how its activation is regulated remains unclear. Here, using IFI16 knockout cells and p204-deficient mice, we demonstrate that the DNA sensor IFI16 enhances IFN-I production to inhibit influenza A virus (IAV) replication. Read More

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Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19.

Signal Transduct Target Ther 2021 May 13;6(1):191. Epub 2021 May 13.

School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal microbiota characteristics identified by shotgun metagenomic sequencing analyses of oropharynx swab specimens from 31 COVID-19 patients, 29 influenza B patients, and 28 healthy controls. Our results revealed a distinct oropharyngeal microbiota composition in the COVID-19 patients, characterized by enrichment of opportunistic pathogens such as Veillonella and Megasphaera and depletion of Pseudopropionibacterium, Rothia, and Streptococcus. Read More

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A regionally specific drinking custom 'Otōri' and its association with alcohol consumption/alcohol use disorders: a cross-sectional study.

BMJ Open 2021 May 13;11(5):e041738. Epub 2021 May 13.

Division of Clinical Epidemiology, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

Objectives: The primary objective was to describe the characteristics of Otōri, a regionally specific drinking custom in the Miyakojima region of Okinawa, Japan, and its participants. The secondary objective was to clarify the distribution of alcohol consumption/alcohol use disorders as measured by the Alcohol Use Disorders Identification Test (AUDIT) and its association with the frequency of engagement in Otōri per month.

Design: Cross-sectional study. Read More

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Impact of prior vaccination on antibody response and influenza-like illness among Australian healthcare workers after influenza vaccination in 2016.

Vaccine 2021 May 10. Epub 2021 May 10.

WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Fielding School of Public Health, University of California, Los Angeles, USA; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address:

Background: Epidemiological studies suggest that influenza vaccine effectiveness decreases with repeated administration. We examined antibody responses to influenza vaccination among healthcare workers (HCWs) by prior vaccination history and determined the incidence of influenza infection.

Methods: HCWs were vaccinated with the 2016 Southern Hemisphere quadrivalent influenza vaccine. Read More

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Changes in sialic acid binding associated with egg adaptation decrease live attenuated influenza virus replication in human nasal epithelial cell cultures.

Vaccine 2021 May 10. Epub 2021 May 10.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, United States. Electronic address:

Live Attenuated Influenza Virus (LAIV) is administered to and replicates in the sinonasal epithelium. Candidate LAIV vaccine strains are selected based on their ability to replicate to a high titer in embryonated hen's eggs, a process that can lead to mutations which alter the receptor binding and antigenic structure of the hemagglutinin (HA) protein. In the 2012-2013 northern hemisphere vaccine, the H3N2 HA vaccine strain contained three amino acid changes - H156Q, G186V and S219Y - which altered HA antigenic structure and thus presumably decreased vaccine efficacy. Read More

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The COVID-19 pandemic momentum: can it be used to support improvements in healthcare worker influenza vaccination.

Authors:
Holly Seale

Expert Rev Vaccines 2021 May 14. Epub 2021 May 14.

School of Population Health, University of New South Wales, Sydney, NSW, Australia.

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Influenza A virus hemagglutinin is produced in different disulfide-bonded states.

Antioxid Redox Signal 2021 May 13. Epub 2021 May 13.

Centenary Institute, 6022, Centenary Institute, Building 93 RPA Missenden Road, Camperdown, Newtown, New South Wales, Australia, 2042;

Aims: Influenza A virus hemagglutinin (HA) binding to sialic acid on lung epithelial cells triggers membrane fusion and infection. Host thiol isomerases have been shown to play a role in Influenza A virus infection and we hypothesised this role involved manipulation of disulfide bonds in HA.

Results: Analysis of HA crystal structures revealed that three of the six HA disulfides occur in high energy conformations and four of the six bonds can exist in unformed states, suggesting that the disulfide landscape of HA is generally strained and the bonds may be labile. Read More

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A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine.

J Autoimmun 2021 May 1;121:102649. Epub 2021 May 1.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens and Academy of Athens, Athens, Greece. Electronic address:

Autoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible patient population. Moreover, preliminary data from vaccinated organ transplanted, inflammatory bowel and connective tissue disease patients suggests only limited immunogenicity after the first vaccine dose, particularly in patients on immunosuppressive regimens. Read More

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Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases.

Bioorg Med Chem Lett 2021 May 10:128099. Epub 2021 May 10.

Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, UAE; College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, UAE. Electronic address:

SARS-CoV-2 caused dramatic health, social and economic threats to the globe. With this threat, the expectation of future outbreak, and the shortage of anti-viral drugs, scientists were challenged to develop novel antivirals. The objective of this study is to develop novel anti-SARS-CoV-2 compounds with dual activity by targeting valuable less-mutated enzymes. Read More

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Performance- and cost-benefit analysis of an influenza point-of-care test compared to laboratory-based multiplex RT-PCR in the emergency department.

Am J Infect Control 2021 May 10. Epub 2021 May 10.

Department of Epidemiology and Infection Prevention, Regional Public Health Laboratory Kennemerland, Haarlem, the Netherlands.. Electronic address:

Introduction: Influenza poses a heavy burden on emergency departments (ED) and hospital wards. Fast and reliable bedside tests are invaluable in obtaining indications for (cohort) droplet isolation precautions and improving patient flow. We performed a cost-benefit analysis comparing influenza point-of-care testing (POCT) to laboratory-based multiplex ligation-dependent probe amplification (MLPA). Read More

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Rapid Detection of Human Respiratory Syncytial Virus A and B by Duplex Real-Time RT-PCR.

J Virol Methods 2021 May 10:114171. Epub 2021 May 10.

WHO Collaborating Centre for Reference and Research on Influenza, Victoria Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Elizabeth Street, Melbourne, VIC, Australia. Electronic address:

Respiratory syncytial virus (RSV) is a common cause of acute respiratory disease worldwide, especially in young children. The World Health Organization (WHO) has initiated an RSV Surveillance Pilot program that aims to perform worldwide RSV surveillance, requiring the development of reliable and rapid molecular methods to detect and identify RSV. A duplex real-time RT-PCR assay developed for simultaneous detection of both A and B subtypes of RSV was included as part of this program. Read More

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Immunogenicity of trivalent seasonal influenza vaccine in patients with chronic obstructive pulmonary disease.

Hum Vaccin Immunother 2021 May 13:1-6. Epub 2021 May 13.

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.

Current evidence on the immunogenicity of influenza vaccination in patients with chronic obstructive pulmonary disease (COPD) is limited. To address this need for additional knowledge, we conducted a study on the immunogenicity of trivalent seasonal influenza vaccine (TIV) in COPD patients. We recruited patients from respiratory outpatient clinics of three hospitals in Tangshan, Hebei province who had stable confirmed COPD, were less than 80 y old, and reported not having had influenza or receiving TIV during the study season prior to enrollment. Read More

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Surveillance of Vaccination Coverage Among Adult Populations -United States, 2018.

MMWR Surveill Summ 2021 May 14;70(3):1-26. Epub 2021 May 14.

Problem/condition: Adults are at risk for illness, hospitalization, disability and, in some cases, death from vaccine-preventable diseases, particularly influenza and pneumococcal disease. CDC recommends vaccinations for adults on the basis of age, health conditions, prior vaccinations, and other considerations. Updated vaccination recommendations from CDC are published annually in the U. Read More

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COVID-19 is not "just another flu": a real-life comparison of severe COVID-19 and influenza in hospitalized patients in Vienna, Austria.

Infection 2021 May 13. Epub 2021 May 13.

Department for Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Kundratstraße 3, 1100, Vienna, Austria.

Background: COVID-19 is regularly compared to influenza. Mortality and case-fatality rates vary widely depending on incidence of COVID-19 and the testing policy in affected countries. To date, data comparing hospitalized patients with COVID-19 and influenza is scarce. Read More

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