902 results match your criteria Inflammopharmacology [Journal]


Antipyretic effect of phytol, possibly via 5KIR-dependent COX-2 inhibition pathway.

Inflammopharmacology 2019 Feb 18. Epub 2019 Feb 18.

Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.

Aims: This study is aimed at the evaluation of antipyretic effect of PHY in yeast-induced hyperthermia rats. Additionally, possible mechanism of antipyretic action of PHY has been also studied by molecular docking study.

Methods: Adult male Wistar albino rats were treated with PHY at 100, 150 and 200 mg/kg in 0. Read More

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http://dx.doi.org/10.1007/s10787-019-00574-9DOI Listing
February 2019

Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants.

Inflammopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, University of California, Los Angeles, CA, 90024, USA.

1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Read More

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http://dx.doi.org/10.1007/s10787-019-00565-wDOI Listing
February 2019

Regulatory effects of paeoniflorin-6'-O-benzene sulfonate (CP-25) on dendritic cells maturation and activation via PGE2-EP4 signaling in adjuvant-induced arthritic rats.

Inflammopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease. Dendritic cells (DCs) are one of the most powerful antigen-presenting cells, and they play an important role in RA pathogenesis. Prostaglandin E2 (PGE2) is a potent lipid mediator that can regulate the maturation and activation of DCs, but the molecular mechanisms have not been elucidated. Read More

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http://dx.doi.org/10.1007/s10787-019-00575-8DOI Listing
February 2019

The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.

Methods: The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. Read More

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http://dx.doi.org/10.1007/s10787-019-00572-xDOI Listing
February 2019

Zinc and its regulators in pancreas.

Inflammopharmacology 2019 Feb 12. Epub 2019 Feb 12.

Key Laboratory of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei, 230032, China.

Studies have demonstrated that susceptibility to type 2 diabetes (T2D) is influenced by common polymorphism in the zinc transporter 8 gene SLC30A8, providing novel insight into the role of zinc in diabetes. Intriguingly, zinc participates in every step of the process, including insulin synthesis, crystallization, storage, secretion and signaling. Zinc deficiency or overload is associated with various disorders, such as diabetes, cardiovascular disease and obesity. Read More

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http://dx.doi.org/10.1007/s10787-019-00573-wDOI Listing
February 2019

Prevalence and current therapy in chronic liver disorders.

Inflammopharmacology 2019 Feb 8. Epub 2019 Feb 8.

TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research Institute, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.

Background: Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Read More

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http://dx.doi.org/10.1007/s10787-019-00562-zDOI Listing
February 2019

Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14.

Inflammopharmacology 2019 Feb 5. Epub 2019 Feb 5.

Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

We investigated effects of magnesium sulfate (MgSO) on modulating lipopolysaccharide (LPS)-macrophage binding and cluster of differentiation 14 (CD14) expression. Flow cytometry data revealed that the mean levels of LPS-macrophage binding and membrane-bound CD14 expression (mCD14) in differentiated THP-1 cells (a human monocytic cell line) treated with LPS plus MgSO (the LPS + M group) decreased by 28.2% and 25. Read More

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http://dx.doi.org/10.1007/s10787-019-00568-7DOI Listing
February 2019
1 Read

Auto-immunity profile evaluation during different clinical manifestations of Behçet disease in Algerian patients: effect of corticosteroid treatment.

Inflammopharmacology 2019 Feb 5. Epub 2019 Feb 5.

Cytokines and NO-Synthases, Laboratory of Cellular and Molecular Biology (LBCM), Faculty of Biological Science, USTHB, PB 32, 16111, Algiers, Algeria.

Background And Aims: Behçet disease (BD) is a chronic multisystem disease. It stands at the crossroads between the auto-immunity and auto-inflammatory disorders. Our study aims to evaluate corticosteroids therapy effects on serum immunoglobulin isotypes and anti-phospholipid auto-anti-body production in Algerian BD patients with different clinical manifestations. Read More

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http://dx.doi.org/10.1007/s10787-019-00567-8DOI Listing
February 2019
1 Read

Identification of bioactive phenolics from Porana sinensis Hemsl. stem by UPLC-QTOF-MS/MS and the confirmation of anti-inflammatory indicators using LPS-induced RAW264.7 cells.

Inflammopharmacology 2019 Jan 28. Epub 2019 Jan 28.

College of Biological Sciences and Technology, Beijing Forestry University, Qinghuadonglu No. 35, Haidian District, Beijing, 100083, China.

To characterise bioactive phenolics and confirm anti-inflammatory indicators in Porana sinensis stem, 23 phenolics were identified by UPLC-QTOF-MS/MS from crude extract (CE) prepared optimally with 80% methanol. Further fractionalisation using D101 macroporous resin resulted in predominant enrichment of total phenols and flavonoids into Fr.II. Read More

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http://dx.doi.org/10.1007/s10787-018-00558-1DOI Listing
January 2019

Anti-inflammatory properties of Liposome-encapsulated clodronate or Anti-Ly6G can be modulated by peripheral or central inflammatory markers in carrageenan-induced inflammation model.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Department of Biophysics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Overproduction of inflammatory markers by immune cells, such as macrophages and neutrophils, is one of the main reasons for many inflammatory conditions and inhibiting or suppressing of their production by cell depletion may provide new therapeutic targets or approaches to prevent a variety of inflammatory conditions. In this study, we examined the possible effects of anti-Ly6G-mediated systemic neutrophil depletion and liposome-encapsulated clodronate (LEC)-mediated systemic macrophage depletion on the inflammatory signs (thermal hyperalgesia, mechanical allodynia, oedema and fever) and measured the levels of various inflammation markers (tumour necrosis factor-α (TNF-α), interleukins (IL)-1β, IL-4, IL-10, macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) and myeloperoxidase (MPO) in paw and spinal cord tissues in carrageenan (CG)-induced hindpaw inflammation model in rats. CG injection into the paw caused inflammation characterized by redness, swelling, heat and pain hypersensitivities. Read More

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http://dx.doi.org/10.1007/s10787-019-00563-yDOI Listing
January 2019

Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3 cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Team Cytokines and NO Synthases-Immunity and Pathogenesis, Laboratory of Cellular and Molecular Biology (LBCM), Faculty of Biological Science, University of Sciences and Technology (USTHB), BP 32 El-Alia Bab-Ezzouar, Algiers, Algeria.

Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we evaluated the link between the iNOS/NO system and CRC progression, its relation with the host immune responses and its response to cetuximab combined with chemotherapy. Read More

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http://dx.doi.org/10.1007/s10787-019-00566-9DOI Listing
January 2019
2 Reads

The intensity of joint pain in relation to changes in serum TNFα during therapy with anti-TNFα inhibitors.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Tumor necrosis factor-alpha (TNFα) inhibitors have significantly improved the outcomes of treatment for rheumatoid arthritis (RA). In the present study, we aimed to determine whether serum levels of TNFα during therapy with TNFα inhibitors do really reflect the disease activity and correspond to the intensity of pain experienced.

Materials And Methods: Thirty RA patients were examined before and after 12 weeks of routine therapy with TNFα inhibitors. Read More

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http://link.springer.com/10.1007/s10787-019-00564-x
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http://dx.doi.org/10.1007/s10787-019-00564-xDOI Listing
January 2019
3 Reads

The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45 hematopoietic cells.

Inflammopharmacology 2019 Jan 5. Epub 2019 Jan 5.

Department of Pathology, Biological Science Center, Londrina State University, Rod. Celso Garcia Cid, PR 445, Km 380, Londrina, Paraná State, 86051-990, Brazil.

Background: Naringenin is a biologically active analgesic, anti-inflammatory, and antioxidant flavonoid. Naringenin targets in inflammation-induced articular pain remain poorly explored.

Methods: The present study investigated the cellular and molecular mechanisms involved in the analgesic/anti-inflammatory effects of naringenin in zymosan-induced arthritis. Read More

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http://dx.doi.org/10.1007/s10787-018-00561-6DOI Listing
January 2019

Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective.

Inflammopharmacology 2019 Jan 4. Epub 2019 Jan 4.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

A number of studies have implicated cannabinoids as potent anti-inflammatory mediators. However, the exact mechanism by which cannabinoids exert these effects remains to be fully explained. The recent resurgence in interest regarding the metabolic adaptations undergone by activated immune cells has highlighted the intricate connection between metabolism and an inflammatory phenotype. Read More

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http://link.springer.com/10.1007/s10787-018-00560-7
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http://dx.doi.org/10.1007/s10787-018-00560-7DOI Listing
January 2019
1 Read

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation.

Inflammopharmacology 2019 Jan 3. Epub 2019 Jan 3.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.

The aging population is burgeoning globally and this trend presents great challenges to the current healthcare system as the growing number of aged individuals receives procedures of surgery and anesthesia. Postoperative cognitive dysfunction (POCD) is a severe postoperative neurological sequela. Advanced age is considered as an independent risk factor of POCD. Read More

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http://dx.doi.org/10.1007/s10787-018-00559-0DOI Listing
January 2019
1 Read

Cerebrospinal inflammatory response following scorpion envenomation: role of histamine H1 and H3 receptors.

Inflammopharmacology 2019 Jan 2. Epub 2019 Jan 2.

USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria.

Background: The mechanism of the inflammatory process induced by scorpion venom in the cerebrospinal tissues has not yet been completely elucidated. Therefore, we aimed to investigate the role of histamine through its H1 and H3 receptors in this process.

Methods: Histamine H1 and H3 receptor antagonists, Hydroxyzine (10 mg/kg) and Betaserc (20 mg/kg), respectively, were administered by intraperitoneal route to mice 1 h before subcutaneous envenomation with a subletal dose (0. Read More

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http://dx.doi.org/10.1007/s10787-018-00553-6DOI Listing
January 2019
3 Reads

International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.

Inflammopharmacology 2019 Jan 2. Epub 2019 Jan 2.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box: 14155-6446, Tehran, Iran.

Background: The oral administration of drug β-D-mannuronic acid (M2000) showed a potent therapeutic effect in phase I/II study in rheumatoid arthritis (RA) patients. Here, our aim is to assess the efficacy and safety of this new drug in RA patients under a multinational, randomized placebo-controlled phase III clinical trial.

Method: Patients (n = 288) with active disease at baseline and inadequate response to conventional drugs were randomly allocated to three groups; (1) receiving mannuronic acid at a dose of two capsules (500 mg) per day orally for 12 weeks, (2) placebo-controlled, and (3) conventional. Read More

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http://link.springer.com/10.1007/s10787-018-00557-2
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http://dx.doi.org/10.1007/s10787-018-00557-2DOI Listing
January 2019
3 Reads

Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Centre for Integrated Preclinical Drug Development, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.

Human immuno-deficiency virus (HIV) associated sensory neuropathy (SN) is a frequent complication of HIV infection. It is extremely difficult to alleviate and hence the quality of life of affected individuals is severely and adversely impacted. Stavudine (d4T) is an antiretroviral drug that was widely used globally prior to 2010 and that is still used today in resource-limited settings. Read More

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http://dx.doi.org/10.1007/s10787-018-00551-8DOI Listing
January 2019

Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research 151, VAMC, 1030 Jefferson Ave, Memphis, TN, 38104, USA.

In this study, we evaluated the hypothesis that immunonanosomes carrying the drug [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1) will help in reducing nuclear factor-kappaB (NF-κB)-associated inflammation in porcine chondrocytes against tumor necrosis factor-alpha (TNF-α)-induced stress. The nanosomes were tagged with monoclonal anti-type II collagen (MabCII) antibody to specifically target the exposed type II collagen in cartilage matrix. TPCA-1 at a concentration of 10 µM significantly reduced expression of the matrix-degrading enzyme, Matrix metalloproteinase-13 (MMP-13) and blocked the p65 nuclear translocation. Read More

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http://dx.doi.org/10.1007/s10787-018-0542-5DOI Listing
January 2019

Proteoglycans isolated from the bramble shark cartilage show potential anti-osteoarthritic properties.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Osteoarthritis (OA) causes articular cartilage destruction, initiating pain and inflammation in the joints, resulting in joint disability. Medications are available to manage these symptoms; however, their effects on the disease progression are limited. Loss of proteoglycans (PGs) was reported to contribute articular cartilage destruction in OA. Read More

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http://dx.doi.org/10.1007/s10787-018-00554-5DOI Listing
January 2019

Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.

Background: Carfilzomib (CFZ), a proteasome inhibitor approved by the FDA to treat multiple myeloma, may cause nephrotoxicity.

Hypothesis: Rutin is a bioflavonoid with antioxidant properties. We aimed to examine whether rutin protects the kidney from CFZ-induced nephrotoxicity. Read More

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http://link.springer.com/10.1007/s10787-018-0550-5
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http://dx.doi.org/10.1007/s10787-018-0550-5DOI Listing
January 2019
3 Reads

Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, Sichuan Province, China.

Background: Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms of resveratrol in patients with gout. Read More

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http://dx.doi.org/10.1007/s10787-018-00555-4DOI Listing
January 2019
2 Reads

Polyphenol-associated oxidative stress and inflammation in a model of LPS-induced inflammation in glial cells: do we know enough for responsible compounding?

Inflammopharmacology 2018 Dec 13. Epub 2018 Dec 13.

Department Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Cyanidin and chlorogenic acid are polyphenols from plant origin that are present in many common fruits, particularly in berries. To corroborate the protective or detrimental effects of both compounds from a neuro-inflammatory perspective, in vitro experiments were carried out in human astrocytes (U-373). Astrocytes were pre-treated with a range of concentrations of either cyanidin, chlorogenic acid or a combined treatment for a period of 30 min, before exposure to Escherichia coli lipopolysaccharide (LPS) challenge for 23. Read More

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http://dx.doi.org/10.1007/s10787-018-0549-yDOI Listing
December 2018
3 Reads

Berberis lycium Royle fruit extract mitigates oxi-inflammatory stress by suppressing NF-κB/MAPK signalling cascade in activated macrophages and Treg proliferation in splenic lymphocytes.

Inflammopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Pharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, HP, 176061, India.

Although Berberis plant species have been advocated as immune modulators, information regarding their mechanism(s) of action is limited. Therefore, in the present study we assessed the efficacy of Berberis lycium Royle fruit extract (BLFE) in the attenuation of lipopolysaccharide (LPS)-induced oxi-inflammatory aggravation and concanavalin A (Con-A)-induced proliferation in murine peritoneal macrophages and lymphocytes, respectively. BLFE strongly suppressed production of the oxidative and inflammatory effector molecules nitric oxide (NO), reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS), inflammatory cytokines (TNF-α/IL-6/IL-1β/IFN-γ) as well as chemokines (MCP-1 and RANTES), with a concomitant enhancement in heme oxygenase-1 (HO-1) and IL-10 levels. Read More

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http://link.springer.com/10.1007/s10787-018-0548-z
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http://dx.doi.org/10.1007/s10787-018-0548-zDOI Listing
December 2018
12 Reads

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model.

Inflammopharmacology 2018 Nov 23. Epub 2018 Nov 23.

Department of Zoology, MMV, Banaras Hindu University, Varanasi, 221005, India.

Objective: Bacterial infections can exacerbate asthmatic inflammation depending on lipopolysaccharide (LPS) composition, the outermost component of cell wall, its exposure timings as well as host's immune status. In present study, Balb/c mice were exposed to antigen (ovalbumin) and LPS simultaneously to establish an asthmatic model. Curcumin (diferuloylmethane), well known for its anti-inflammatory potential, was administered through intranasal route 1 h before LPS and OVA (ovalbumin) exposure to evaluate its efficacy against airway structural changes. Read More

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http://dx.doi.org/10.1007/s10787-018-0544-3DOI Listing
November 2018
10 Reads

Stress as an immunomodulator: liver X receptors maybe the answer.

Inflammopharmacology 2018 Nov 22. Epub 2018 Nov 22.

Institut de radioprotection et de sûreté nucléaire, Direction de la radioprotection de l'homme, IRSN, Fontenay-aux-Roses Cedex, France.

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Read More

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http://dx.doi.org/10.1007/s10787-018-0546-1DOI Listing
November 2018
21 Reads

Inhibitory effects of Clematis orientalis aqueous ethanol extract and fractions on inflammatory markers in complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

Laboratory Rashid Latif College of Pharmacy, Lahore, Pakistan.

Clematis orientalis Linn has long been used as ethnopharmacy for the treatment of arthritis. This study is intended to evaluate the curative efficacy of Clematis orientalis in treating polyarthritis in rats. Aqueous ethanolic extract and fractions (hexane, butanol and aqueous) were administered orally at 200 mg/kg for 28 days after CFA immunization. Read More

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http://dx.doi.org/10.1007/s10787-018-0543-4DOI Listing
November 2018
1 Read

Plantago squarrosa Murray extracts inhibit the growth of some bacterial triggers of autoimmune diseases: GC-MS analysis of an inhibitory extract.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, QLD, 4111, Australia.

Ankylosing spondylitis, multiple sclerosis, rheumatoid arthritis and rheumatic fever are autoimmune inflammatory diseases that may be triggered in genetically susceptible individuals by specific bacterial pathogens. Inhibiting the growth of these bacteria with high antioxidant plant extracts may inhibit the aetiology of these diseases, as well as inhibiting the later phase symptoms. P. Read More

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http://link.springer.com/10.1007/s10787-018-0547-0
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http://dx.doi.org/10.1007/s10787-018-0547-0DOI Listing
November 2018
18 Reads

Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.

Inflammopharmacology 2018 Nov 13. Epub 2018 Nov 13.

Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Ministry of Education, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.

The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Read More

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http://link.springer.com/10.1007/s10787-018-0545-2
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http://dx.doi.org/10.1007/s10787-018-0545-2DOI Listing
November 2018
10 Reads

Intraarticular injection of dexamethasone promotes bone erosion in collagen-induced arthritis in mice through up-regulation of RANKL expression.

Inflammopharmacology 2018 Oct 20. Epub 2018 Oct 20.

Department of Rheumatology, Jiangsu Province Hospital, Nanjing Medical University First Affiliated Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.

Background: Dexamethasone (DEX) is an effective therapeutic option commonly used in the treatment of many inflammatory diseases. However, DEX could impair proliferation or differentiation of osteoblasts, suggesting a pivotal role of DEX in bone destruction.

Objective: To investigate whether intraarticular injection of DEX could exacerbate bone erosion during CIA development. Read More

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http://link.springer.com/10.1007/s10787-018-0541-6
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http://dx.doi.org/10.1007/s10787-018-0541-6DOI Listing
October 2018
7 Reads

Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus.

Inflammopharmacology 2018 Oct 20. Epub 2018 Oct 20.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP. Read More

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http://dx.doi.org/10.1007/s10787-018-0540-7DOI Listing
October 2018
1 Read

The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial.

Inflammopharmacology 2018 Oct 16. Epub 2018 Oct 16.

Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP). Read More

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http://link.springer.com/10.1007/s10787-018-0539-0
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http://dx.doi.org/10.1007/s10787-018-0539-0DOI Listing
October 2018
1 Read

Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats.

Inflammopharmacology 2018 Dec 15;26(6):1399-1413. Epub 2018 Oct 15.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: There are several lines of evidence on the protective roles of opioids in gastrointestinal inflammatory conditions. This study aims to distinguish the central and peripheral roles of methadone, a non-selective opioid receptor agonist, in an acute model of ulcerative colitis in male rats.

Methods: Ulcerative colitis was induced by intrarectal administration of acetic acid 4%. Read More

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http://dx.doi.org/10.1007/s10787-018-0538-1DOI Listing
December 2018
2 Reads

Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.

Inflammopharmacology 2018 Oct 13. Epub 2018 Oct 13.

Neuroscience Department, Faculty of Medicine, University of Chile, Santiago, Chile.

Neuropathic pain is a complication of cancer and diabetes mellitus and the most commonly used drugs in the treatment of the diabetic neuropathic pain have only limited efficacy. The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ß) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain. CF-1 male mice, pretreated with 200 mg/kg i. Read More

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http://link.springer.com/10.1007/s10787-018-0532-7
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http://dx.doi.org/10.1007/s10787-018-0532-7DOI Listing
October 2018
2 Reads

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice.

Inflammopharmacology 2018 Oct 5. Epub 2018 Oct 5.

The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

Multiple sclerosis (MS) is an autoimmune disease leading to the destruction of myelin with consequent axonal degeneration and severe physical debilitation. The disease can be treated with immunosuppressive drugs that alleviate the symptoms and retard disease aggravation. One such drug in clinical use is glatiramer acetate (Copaxone). Read More

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http://link.springer.com/10.1007/s10787-018-0536-3
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http://dx.doi.org/10.1007/s10787-018-0536-3DOI Listing
October 2018
1 Read

Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress.

Inflammopharmacology 2018 Oct 5. Epub 2018 Oct 5.

Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran.

Background: The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated.

Methods: Control, LPS, 12. Read More

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http://link.springer.com/10.1007/s10787-018-0535-4
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http://dx.doi.org/10.1007/s10787-018-0535-4DOI Listing
October 2018
14 Reads

Luteolin suppresses inflammation through inhibiting cAMP-phosphodiesterases activity and expression of adhesion molecules in microvascular endothelial cells.

Inflammopharmacology 2018 Oct 1. Epub 2018 Oct 1.

Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, 7 Beinong Road, Huilongguan Town, Changping District, Beijing, 102206, China.

Luteolin, an anti-inflammatory ingredient found in the Chinese herb Folium perillae, can inhibit not only the cyclic adenosine monophosphate (cAMP)-phosphodiesterases (PDEs) activity of neutrophils, but also the expression of lymphocyte function-associated antigen-1 in neutrophils, both of which result in a decrease in the adhesion between neutrophils and microvascular endothelial cells. However, the effect of luteolin on the cAMP-PDEs activity and expression of adhesion molecules in endothelial cells are not clear. In the present study, primary rat pulmonary microvascular endothelial cells and a lipopolysaccharide-induced rat acute pneumonia model were used to explore the role of luteolin on cAMP-PDEs activity, expression of adhesion molecules, and leukocyte infiltration. Read More

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http://dx.doi.org/10.1007/s10787-018-0537-2DOI Listing
October 2018
1 Read

Anti-inflammatory effects of Chinese propolis in lipopolysaccharide-stimulated human umbilical vein endothelial cells by suppressing autophagy and MAPK/NF-κB signaling pathway.

Inflammopharmacology 2018 Sep 24. Epub 2018 Sep 24.

College of Animal Sciences, Zhejiang University, Hangzhou, 310029, China.

This study aimed to investigate the possible benefits of Chinese poplar propolis (CP) in inhibiting inflammation using vascular endothelial cells (VECs) cultured in a nutrient-rich condition exposed to lipopolysaccharide (LPS). Cell proliferation was detected by sulforhodamine B assay and EdU kit. The production of reactive oxygen species (ROS) and level of mitochondrial membrane potential were determined with fluorescent probe DCHF and JC-1, respectively. Read More

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http://dx.doi.org/10.1007/s10787-018-0533-6DOI Listing
September 2018
2 Reads

Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway.

Inflammopharmacology 2018 Sep 22. Epub 2018 Sep 22.

Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Ponicidin (PON), a natural diterpenoid compound, has been shown to exhibit potent anticancer activities in a wide variety of cancers, including colorectal cancer (CRC). Nevertheless, the precise mechanisms underlying the anti-metastasis effect of PON have not yet been completely defined. The present study was designed to uncover the inhibitory effect of PON on epithelial-mesenchymal transition (EMT), migration and invasion of HCT116 cells induced by pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) in vitro, and liver metastasis in vivo. Read More

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http://dx.doi.org/10.1007/s10787-018-0534-5DOI Listing
September 2018

IL-1β, IL-17A and combined phototherapy predicts higher while previous systemic biologic treatment predicts lower treatment response to etanercept in psoriasis patients.

Inflammopharmacology 2018 Sep 21. Epub 2018 Sep 21.

Department of Dermatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.

Background: This study aimed to explore the correlation of circulating inflammatory cytokines' levels with treatment response to etanercept (ETN) treatment in psoriasis patients.

Methods: 97 moderate-to-severe plaque-psoriasis patients were continuously recruited in this prospective cohort study, and all patients received ETN treatment. Serum samples were collected before and at 6 months (M6) after treatment, and nine inflammatory cytokines expressions were detected by enzyme-linked immuno sorbent assay. Read More

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http://dx.doi.org/10.1007/s10787-018-0530-9DOI Listing
September 2018

The significant impact of apigenin on different aspects of autoimmune disease.

Inflammopharmacology 2018 Dec 18;26(6):1359-1373. Epub 2018 Sep 18.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Box 8174673461, Isfahan, Iran.

Autoimmune diseases are among the highest diseases to diagnose and treat. The current "gold standard" of care for these diseases is immunosuppressive drugs which interfere with overall immune responses; their long-term high-dose treatments would expose the patient to opportunistic, life-threatening and long-term malignant infections. Considering the side effects and toxicity of these drug and also the beneficial effects of herbal compounds among their consumers, the professional investigation on the exact mechanism of the plant's major element has grown much attention in the last years. Read More

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http://dx.doi.org/10.1007/s10787-018-0531-8DOI Listing
December 2018

Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation.

Inflammopharmacology 2018 Sep 15. Epub 2018 Sep 15.

Bio-organic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, 211007, India.

Oxidative stress and inflammation play a pivotal role in the expansion and progression of hepatic cancer. Nanoparticle-based drug delivery can quickly enhance the restorative capability of hepatic cancer. Silver nanoparticles synthesized from plant source are of great importance due to their small size, economic, non-hazardous and different biomedical applications. Read More

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http://dx.doi.org/10.1007/s10787-018-0525-6DOI Listing
September 2018
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Nimbolide ameliorates fibrosis and inflammation in experimental murine model of bleomycin-induced scleroderma.

Inflammopharmacology 2018 Sep 14. Epub 2018 Sep 14.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.

Background: Clinical manifestations of skin fibrosis are very variable and ambiguous, making its management quite critical and challenging. The lack of appropriate established pharmacological interventions make its treatment even more complicated. Intricate details of the underlying pathogenesis are thus imperative to further explore different treatment possibilities. Read More

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http://dx.doi.org/10.1007/s10787-018-0527-4DOI Listing
September 2018
1 Read

Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis.

Inflammopharmacology 2018 Sep 12. Epub 2018 Sep 12.

Programa de Doctorado en Farmacología, CUCS, U de G, Guadalajara, Jalisco, Mexico.

Objectives: To evaluate the utility of elevated serum P-glycoprotein (P-gp) as a risk marker of therapeutic response failure in rheumatoid arthritis (RA) patients treated with disease-modifying antirheumatic drugs (DMARDs).

Methods: A cross-sectional study was conducted in 151 RA patients. Patients were classified into two groups according to the response achieved in terms of the disease activity score (DAS)28 after ≥ 6 months: (1) patients with a therapeutic response to DMARDs, with DAS28 < 3. Read More

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http://dx.doi.org/10.1007/s10787-018-0529-2DOI Listing
September 2018
1 Read

Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis.

Inflammopharmacology 2018 Sep 12. Epub 2018 Sep 12.

Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego str., 02-106, Warsaw, Poland.

Microglia-mediated neuroinflammation accompanies many central nervous system (CNS) diseases, including multiple sclerosis (MS), and is strongly dependent on the purinergic P2X7 receptor. The nature of the inflammatory response in MS is studied for decades indicating, that proinflammatory microgliosis is involved in advanced stages of MS and is associated with active tissue damage and neurological dysfunctions. Evidence on the role of microgliosis in initial stages of the disease is scarce. Read More

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http://dx.doi.org/10.1007/s10787-018-0528-3DOI Listing
September 2018

Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models.

Inflammopharmacology 2018 Sep 8. Epub 2018 Sep 8.

Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman, 19328, Jordan.

Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. Read More

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http://dx.doi.org/10.1007/s10787-018-0524-7DOI Listing
September 2018
16 Reads

Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.

Inflammopharmacology 2018 Sep 4. Epub 2018 Sep 4.

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Dizocilpine is a highly selective and potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor. It is well known that dizocilpine has different neuroprotective effects in animal models of pain, epilepsy and oedema during trauma. The search for alternative antiinflammatory drugs is ongoing. Read More

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http://dx.doi.org/10.1007/s10787-018-0526-5DOI Listing
September 2018
2 Reads

Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway.

Inflammopharmacology 2018 Aug 24. Epub 2018 Aug 24.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Aim: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway and activation of melatonin receptor.

Methods: Colitis was induced in Wistar rats by administration of 100 mg/kg TNBS dissolved in 0.25 ml of 50% ethanol solution using a flexible plastic rubber catheter into the colon via the anus. Read More

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http://link.springer.com/10.1007/s10787-018-0523-8
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http://dx.doi.org/10.1007/s10787-018-0523-8DOI Listing
August 2018
3 Reads

Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-κB signaling pathway and attenuating endoplasmic reticulum stress.

Inflammopharmacology 2018 Aug 11. Epub 2018 Aug 11.

College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, People's Republic of China.

Rutin, found widely in traditional Chinese medicine materials, is used to treat eye swelling and pain, hypertension, and hyperlipidemia. In the present study, a mouse mastitis model induced by lipopolysaccharide (LPS) was established to explore rutin's inhibitory mechanism on mastitis via nuclear factor kappa B (NF-κB) inflammatory signaling and the relationship between NF-κB signaling and endoplasmic reticulum (ER) stress. Mice were divided into six groups: Control group, LPS model group, LPS + rutin (25, 50, and 100 mg/kg) and LPS + dexamethasone (DEX) group. Read More

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http://dx.doi.org/10.1007/s10787-018-0521-xDOI Listing
August 2018
3 Reads

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy.

Inflammopharmacology 2018 Aug 9. Epub 2018 Aug 9.

Department of General Surgery, Renmin Hospital of Wuhan University, No.99 Zhang Zhidong Road, Wuhan, 430060, Hubei, China.

Acute pancreatitis in pregnancy (APIP) can lead to multiple maternal and fetal organ injury and mitogen-activated protein kinase (MAPK) signaling pathway may be involved in it; however, whether APIP can result in acute lung injury and P38MAPK signaling pathway is involved in the pathogenesis has not been elucidated. The present study was undertaken to investigate the participation of P38MAPK signaling pathway and the protective effect of SB203580, an inhibitor of P38MAPK on acute lung injury induced by APIP. Twenty-four late-gestation SD rats were randomly assigned to four groups: Sham operation (SO) group, SB302580 (SB) group, APIP group, and SB + APIP group. Read More

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http://dx.doi.org/10.1007/s10787-018-0522-9DOI Listing
August 2018
5 Reads