881 results match your criteria Inflammopharmacology [Journal]


Polyphenol-associated oxidative stress and inflammation in a model of LPS-induced inflammation in glial cells: do we know enough for responsible compounding?

Inflammopharmacology 2018 Dec 13. Epub 2018 Dec 13.

Department Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Cyanidin and chlorogenic acid are polyphenols from plant origin that are present in many common fruits, particularly in berries. To corroborate the protective or detrimental effects of both compounds from a neuro-inflammatory perspective, in vitro experiments were carried out in human astrocytes (U-373). Astrocytes were pre-treated with a range of concentrations of either cyanidin, chlorogenic acid or a combined treatment for a period of 30 min, before exposure to Escherichia coli lipopolysaccharide (LPS) challenge for 23. Read More

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December 2018

Berberis lycium Royle fruit extract mitigates oxi-inflammatory stress by suppressing NF-κB/MAPK signalling cascade in activated macrophages and Treg proliferation in splenic lymphocytes.

Inflammopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Pharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, HP, 176061, India.

Although Berberis plant species have been advocated as immune modulators, information regarding their mechanism(s) of action is limited. Therefore, in the present study we assessed the efficacy of Berberis lycium Royle fruit extract (BLFE) in the attenuation of lipopolysaccharide (LPS)-induced oxi-inflammatory aggravation and concanavalin A (Con-A)-induced proliferation in murine peritoneal macrophages and lymphocytes, respectively. BLFE strongly suppressed production of the oxidative and inflammatory effector molecules nitric oxide (NO), reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS), inflammatory cytokines (TNF-α/IL-6/IL-1β/IFN-γ) as well as chemokines (MCP-1 and RANTES), with a concomitant enhancement in heme oxygenase-1 (HO-1) and IL-10 levels. Read More

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December 2018
7 Reads

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model.

Inflammopharmacology 2018 Nov 23. Epub 2018 Nov 23.

Department of Zoology, MMV, Banaras Hindu University, Varanasi, 221005, India.

Objective: Bacterial infections can exacerbate asthmatic inflammation depending on lipopolysaccharide (LPS) composition, the outermost component of cell wall, its exposure timings as well as host's immune status. In present study, Balb/c mice were exposed to antigen (ovalbumin) and LPS simultaneously to establish an asthmatic model. Curcumin (diferuloylmethane), well known for its anti-inflammatory potential, was administered through intranasal route 1 h before LPS and OVA (ovalbumin) exposure to evaluate its efficacy against airway structural changes. Read More

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November 2018
5 Reads

Stress as an immunomodulator: liver X receptors maybe the answer.

Inflammopharmacology 2018 Nov 22. Epub 2018 Nov 22.

Institut de radioprotection et de sûreté nucléaire, Direction de la radioprotection de l'homme, IRSN, Fontenay-aux-Roses Cedex, France.

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Read More

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November 2018
8 Reads

Inhibitory effects of Clematis orientalis aqueous ethanol extract and fractions on inflammatory markers in complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

Laboratory Rashid Latif College of Pharmacy, Lahore, Pakistan.

Clematis orientalis Linn has long been used as ethnopharmacy for the treatment of arthritis. This study is intended to evaluate the curative efficacy of Clematis orientalis in treating polyarthritis in rats. Aqueous ethanolic extract and fractions (hexane, butanol and aqueous) were administered orally at 200 mg/kg for 28 days after CFA immunization. Read More

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November 2018
1 Read

Plantago squarrosa Murray extracts inhibit the growth of some bacterial triggers of autoimmune diseases: GC-MS analysis of an inhibitory extract.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, QLD, 4111, Australia.

Ankylosing spondylitis, multiple sclerosis, rheumatoid arthritis and rheumatic fever are autoimmune inflammatory diseases that may be triggered in genetically susceptible individuals by specific bacterial pathogens. Inhibiting the growth of these bacteria with high antioxidant plant extracts may inhibit the aetiology of these diseases, as well as inhibiting the later phase symptoms. P. Read More

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November 2018
4 Reads

Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.

Inflammopharmacology 2018 Nov 13. Epub 2018 Nov 13.

Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Ministry of Education, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.

The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Read More

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November 2018
7 Reads

Intraarticular injection of dexamethasone promotes bone erosion in collagen-induced arthritis in mice through up-regulation of RANKL expression.

Inflammopharmacology 2018 Oct 20. Epub 2018 Oct 20.

Department of Rheumatology, Jiangsu Province Hospital, Nanjing Medical University First Affiliated Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.

Background: Dexamethasone (DEX) is an effective therapeutic option commonly used in the treatment of many inflammatory diseases. However, DEX could impair proliferation or differentiation of osteoblasts, suggesting a pivotal role of DEX in bone destruction.

Objective: To investigate whether intraarticular injection of DEX could exacerbate bone erosion during CIA development. Read More

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October 2018
7 Reads

Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus.

Inflammopharmacology 2018 Oct 20. Epub 2018 Oct 20.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP. Read More

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October 2018
1 Read

The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial.

Inflammopharmacology 2018 Oct 16. Epub 2018 Oct 16.

Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP). Read More

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October 2018
1 Read

Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats.

Inflammopharmacology 2018 Dec 15;26(6):1399-1413. Epub 2018 Oct 15.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: There are several lines of evidence on the protective roles of opioids in gastrointestinal inflammatory conditions. This study aims to distinguish the central and peripheral roles of methadone, a non-selective opioid receptor agonist, in an acute model of ulcerative colitis in male rats.

Methods: Ulcerative colitis was induced by intrarectal administration of acetic acid 4%. Read More

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December 2018
1 Read

Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.

Inflammopharmacology 2018 Oct 13. Epub 2018 Oct 13.

Neuroscience Department, Faculty of Medicine, University of Chile, Santiago, Chile.

Neuropathic pain is a complication of cancer and diabetes mellitus and the most commonly used drugs in the treatment of the diabetic neuropathic pain have only limited efficacy. The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ß) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain. CF-1 male mice, pretreated with 200 mg/kg i. Read More

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October 2018
2 Reads

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice.

Inflammopharmacology 2018 Oct 5. Epub 2018 Oct 5.

The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

Multiple sclerosis (MS) is an autoimmune disease leading to the destruction of myelin with consequent axonal degeneration and severe physical debilitation. The disease can be treated with immunosuppressive drugs that alleviate the symptoms and retard disease aggravation. One such drug in clinical use is glatiramer acetate (Copaxone). Read More

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October 2018
1 Read

Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress.

Inflammopharmacology 2018 Oct 5. Epub 2018 Oct 5.

Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran.

Background: The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated.

Methods: Control, LPS, 12. Read More

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October 2018
8 Reads

Luteolin suppresses inflammation through inhibiting cAMP-phosphodiesterases activity and expression of adhesion molecules in microvascular endothelial cells.

Inflammopharmacology 2018 Oct 1. Epub 2018 Oct 1.

Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, 7 Beinong Road, Huilongguan Town, Changping District, Beijing, 102206, China.

Luteolin, an anti-inflammatory ingredient found in the Chinese herb Folium perillae, can inhibit not only the cyclic adenosine monophosphate (cAMP)-phosphodiesterases (PDEs) activity of neutrophils, but also the expression of lymphocyte function-associated antigen-1 in neutrophils, both of which result in a decrease in the adhesion between neutrophils and microvascular endothelial cells. However, the effect of luteolin on the cAMP-PDEs activity and expression of adhesion molecules in endothelial cells are not clear. In the present study, primary rat pulmonary microvascular endothelial cells and a lipopolysaccharide-induced rat acute pneumonia model were used to explore the role of luteolin on cAMP-PDEs activity, expression of adhesion molecules, and leukocyte infiltration. Read More

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October 2018

Anti-inflammatory effects of Chinese propolis in lipopolysaccharide-stimulated human umbilical vein endothelial cells by suppressing autophagy and MAPK/NF-κB signaling pathway.

Inflammopharmacology 2018 Sep 24. Epub 2018 Sep 24.

College of Animal Sciences, Zhejiang University, Hangzhou, 310029, China.

This study aimed to investigate the possible benefits of Chinese poplar propolis (CP) in inhibiting inflammation using vascular endothelial cells (VECs) cultured in a nutrient-rich condition exposed to lipopolysaccharide (LPS). Cell proliferation was detected by sulforhodamine B assay and EdU kit. The production of reactive oxygen species (ROS) and level of mitochondrial membrane potential were determined with fluorescent probe DCHF and JC-1, respectively. Read More

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September 2018

Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway.

Inflammopharmacology 2018 Sep 22. Epub 2018 Sep 22.

Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Ponicidin (PON), a natural diterpenoid compound, has been shown to exhibit potent anticancer activities in a wide variety of cancers, including colorectal cancer (CRC). Nevertheless, the precise mechanisms underlying the anti-metastasis effect of PON have not yet been completely defined. The present study was designed to uncover the inhibitory effect of PON on epithelial-mesenchymal transition (EMT), migration and invasion of HCT116 cells induced by pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) in vitro, and liver metastasis in vivo. Read More

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September 2018

IL-1β, IL-17A and combined phototherapy predicts higher while previous systemic biologic treatment predicts lower treatment response to etanercept in psoriasis patients.

Inflammopharmacology 2018 Sep 21. Epub 2018 Sep 21.

Department of Dermatology, The People's Hospital of Shiyan, The Affiliated People's Hospital, Hubei University of Medicine, 39 Middle Chaoyang Road, Shiyan, 442000, China.

Background: This study aimed to explore the correlation of circulating inflammatory cytokines' levels with treatment response to etanercept (ETN) treatment in psoriasis patients.

Methods: 97 moderate-to-severe plaque-psoriasis patients were continuously recruited in this prospective cohort study, and all patients received ETN treatment. Serum samples were collected before and at 6 months (M6) after treatment, and nine inflammatory cytokines expressions were detected by enzyme-linked immuno sorbent assay. Read More

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September 2018

The significant impact of apigenin on different aspects of autoimmune disease.

Inflammopharmacology 2018 Dec 18;26(6):1359-1373. Epub 2018 Sep 18.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Box 8174673461, Isfahan, Iran.

Autoimmune diseases are among the highest diseases to diagnose and treat. The current "gold standard" of care for these diseases is immunosuppressive drugs which interfere with overall immune responses; their long-term high-dose treatments would expose the patient to opportunistic, life-threatening and long-term malignant infections. Considering the side effects and toxicity of these drug and also the beneficial effects of herbal compounds among their consumers, the professional investigation on the exact mechanism of the plant's major element has grown much attention in the last years. Read More

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December 2018

Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation.

Inflammopharmacology 2018 Sep 15. Epub 2018 Sep 15.

Bio-organic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, 211007, India.

Oxidative stress and inflammation play a pivotal role in the expansion and progression of hepatic cancer. Nanoparticle-based drug delivery can quickly enhance the restorative capability of hepatic cancer. Silver nanoparticles synthesized from plant source are of great importance due to their small size, economic, non-hazardous and different biomedical applications. Read More

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September 2018
6 Reads

Nimbolide ameliorates fibrosis and inflammation in experimental murine model of bleomycin-induced scleroderma.

Inflammopharmacology 2018 Sep 14. Epub 2018 Sep 14.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.

Background: Clinical manifestations of skin fibrosis are very variable and ambiguous, making its management quite critical and challenging. The lack of appropriate established pharmacological interventions make its treatment even more complicated. Intricate details of the underlying pathogenesis are thus imperative to further explore different treatment possibilities. Read More

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September 2018
1 Read

Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis.

Inflammopharmacology 2018 Sep 12. Epub 2018 Sep 12.

Programa de Doctorado en Farmacología, CUCS, U de G, Guadalajara, Jalisco, Mexico.

Objectives: To evaluate the utility of elevated serum P-glycoprotein (P-gp) as a risk marker of therapeutic response failure in rheumatoid arthritis (RA) patients treated with disease-modifying antirheumatic drugs (DMARDs).

Methods: A cross-sectional study was conducted in 151 RA patients. Patients were classified into two groups according to the response achieved in terms of the disease activity score (DAS)28 after ≥ 6 months: (1) patients with a therapeutic response to DMARDs, with DAS28 < 3. Read More

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September 2018
1 Read

Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis.

Inflammopharmacology 2018 Sep 12. Epub 2018 Sep 12.

Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego str., 02-106, Warsaw, Poland.

Microglia-mediated neuroinflammation accompanies many central nervous system (CNS) diseases, including multiple sclerosis (MS), and is strongly dependent on the purinergic P2X7 receptor. The nature of the inflammatory response in MS is studied for decades indicating, that proinflammatory microgliosis is involved in advanced stages of MS and is associated with active tissue damage and neurological dysfunctions. Evidence on the role of microgliosis in initial stages of the disease is scarce. Read More

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September 2018

Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models.

Inflammopharmacology 2018 Sep 8. Epub 2018 Sep 8.

Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman, 19328, Jordan.

Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. Read More

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September 2018
6 Reads

Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.

Inflammopharmacology 2018 Sep 4. Epub 2018 Sep 4.

Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Dizocilpine is a highly selective and potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor. It is well known that dizocilpine has different neuroprotective effects in animal models of pain, epilepsy and oedema during trauma. The search for alternative antiinflammatory drugs is ongoing. Read More

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September 2018

Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway.

Inflammopharmacology 2018 Aug 24. Epub 2018 Aug 24.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Aim: The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway and activation of melatonin receptor.

Methods: Colitis was induced in Wistar rats by administration of 100 mg/kg TNBS dissolved in 0.25 ml of 50% ethanol solution using a flexible plastic rubber catheter into the colon via the anus. Read More

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Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-κB signaling pathway and attenuating endoplasmic reticulum stress.

Inflammopharmacology 2018 Aug 11. Epub 2018 Aug 11.

College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, People's Republic of China.

Rutin, found widely in traditional Chinese medicine materials, is used to treat eye swelling and pain, hypertension, and hyperlipidemia. In the present study, a mouse mastitis model induced by lipopolysaccharide (LPS) was established to explore rutin's inhibitory mechanism on mastitis via nuclear factor kappa B (NF-κB) inflammatory signaling and the relationship between NF-κB signaling and endoplasmic reticulum (ER) stress. Mice were divided into six groups: Control group, LPS model group, LPS + rutin (25, 50, and 100 mg/kg) and LPS + dexamethasone (DEX) group. Read More

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August 2018
2 Reads

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy.

Inflammopharmacology 2018 Aug 9. Epub 2018 Aug 9.

Department of General Surgery, Renmin Hospital of Wuhan University, No.99 Zhang Zhidong Road, Wuhan, 430060, Hubei, China.

Acute pancreatitis in pregnancy (APIP) can lead to multiple maternal and fetal organ injury and mitogen-activated protein kinase (MAPK) signaling pathway may be involved in it; however, whether APIP can result in acute lung injury and P38MAPK signaling pathway is involved in the pathogenesis has not been elucidated. The present study was undertaken to investigate the participation of P38MAPK signaling pathway and the protective effect of SB203580, an inhibitor of P38MAPK on acute lung injury induced by APIP. Twenty-four late-gestation SD rats were randomly assigned to four groups: Sham operation (SO) group, SB302580 (SB) group, APIP group, and SB + APIP group. Read More

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August 2018
2 Reads

Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress.

Inflammopharmacology 2018 Aug 2. Epub 2018 Aug 2.

Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: The study was conducted to examine therapeutic effects of lavender oil (LO) against myocardial infarction (MI) and its potential mechanisms.

Methods: A rat model of MI was established and LO (100, 200 and 300 mg/kg) was intraperitoneally administrated immediately after ischemia. Anti-inflammatory and antioxidant activity of LO were evaluated by immunohistochemical assay and measurement of SOD, GSH, and MDA. Read More

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August 2018
14 Reads

Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles.

Inflammopharmacology 2018 Aug 1. Epub 2018 Aug 1.

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: The role of proinflammatory cytokines in adiposity is well established. The anti-inflammatory and antihyperglycemia effects of Boswellia serrata (B. Serrata) gum have been demonstrated by many investigators. Read More

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Correction to: Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment of acute gout: a meta-analysis of randomized controlled trials.

Inflammopharmacology 2018 Jul 30. Epub 2018 Jul 30.

College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen Road 548, Hangzhou, 310053, Zhejiang, China.

The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. Read More

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July 2018
6 Reads

Influence of disease-modifying antirheumatic drugs on oxidative and nitrosative stress in patients with rheumatoid arthritis.

Inflammopharmacology 2018 Oct 30;26(5):1151-1164. Epub 2018 Jul 30.

Department of Internal Medicine, University of Londrina, Robert Koch Avenue no. 60 Bairro Cervejaria, Londrina, Paraná, CEP: 86038-440, Brazil.

Background: Nitro-oxidative stress plays a central role in the pathogenesis of rheumatoid arthritis (RA) and several articles show correlation with disease activity. However, the influence and mechanisms by which disease-modifying antirheumatic drugs (DMARDs) may interfere with nitro-oxidative stress are poorly understood.

Objective: To show the available data on the effect of the DMARDs on the nitro-oxidative stress in RA patients. Read More

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October 2018

Diagnostic value of salivary CRP and IL-6 in patients undergoing anti-TNF-alpha therapy for rheumatic disease.

Inflammopharmacology 2018 Oct 24;26(5):1183-1188. Epub 2018 Jul 24.

Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Saliva has been increasingly used as a diagnostic medium for disease detection and monitoring. The aim of this observational, prospective, pilot study was to investigate whether salivary concentrations of CRP and IL-6 correlate with those in serum and with the clinical course of a rheumatic disease.

Materials And Methods: Nineteen patients with rheumatic disease newly scheduled for anti-TNFα therapy were included. Read More

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October 2018
8 Reads

Molecular docking and pharmacological/toxicological assessment of a new compound designed from celecoxib and paracetamol by molecular hybridization.

Inflammopharmacology 2018 Oct 23;26(5):1189-1206. Epub 2018 Jul 23.

Laboratory of Pharmacology of Natural and Synthetic Products, Department of Pharmacology, Institute of Biological Sciences, Federal University of Goiás, Campus Samambaia - ICB 2 - Sala 216, CP 131, Goiânia, GO, CEP 74001-970, Brazil.

Nonsteroidal anti-inflammatory drugs are commonly used worldwide; however, they have several adverse effects, evidencing the need for the development of new, more effective and safe anti-inflammatory and analgesic drugs. This research aimed to design, synthesize and carry out a pharmacological/toxicological investigation of LQFM-102, which was designed from celecoxib and paracetamol by molecular hybridization. To evaluate the analgesic effect of this compound, we performed formalin-induced pain, hot plate and tail flick tests. Read More

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October 2018
1 Read

25-hydroxycholesterol reduces inflammation, viral load and cell death in ZIKV-infected U-87 MG glial cell line.

Inflammopharmacology 2018 Jul 17. Epub 2018 Jul 17.

University of Trieste, Piazzale Europa 1, 34128, Trieste, Italy.

Zika virus (ZIKV) infection is a global health issue due to its worldwide diffusion and to the related effects on neural progenitor cells with severe consequences on developing brain as well as on the central nervous system of adults. Previous studies showed that ZIKV infection induces an increment of IL1B expression in the central nervous system and also in the blood. IL-1β is a pro-inflammatory cytokine essential for cellular defence, tissue repair and neuroinflammation, a mechanism seen to be associated with several neuroinflammatory diseases. Read More

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July 2018
1 Read

Terminalia bellirica (Gaertn.) Roxb fruit exerts anti-inflammatory effect via regulating arachidonic acid pathway and pro-inflammatory cytokines in lipopolysaccharide-induced RAW 264.7 macrophages.

Inflammopharmacology 2018 Jul 12. Epub 2018 Jul 12.

School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.

Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India, has been used for centuries in Ayurveda, a universal system of medicine in India. Read More

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July 2018
7 Reads

Efficacy analysis of hydroxychloroquine therapy in systemic lupus erythematosus: a study on disease activity and immunological biomarkers.

Inflammopharmacology 2018 Jul 10. Epub 2018 Jul 10.

Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Background: Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines in SLE patients.

Methods: In this prospective cohort study, 41 newly diagnosed SLE patients receiving 400 mg HCQ per day were included. Read More

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July 2018
4 Reads

Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model.

Inflammopharmacology 2018 Jul 6. Epub 2018 Jul 6.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

This study was conducted to evaluate the effects of the prepared ointments from Mentha piperita essential oil (M. piperita) on wound healing in the infected mice models. Each circular full-thickness wound was inoculated with 25 × 10 units of Staphylococcus aureus and Pseudomonas aeruginosa bacteria strains. Read More

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July 2018
1 Read

Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b.

Inflammopharmacology 2018 Jul 5. Epub 2018 Jul 5.

Department of Orthopaedic Surgery, Nanjing Medical University Affiliated Wuxi Second Hospital, 68 Zhongshan Road, 214001, Wuxi, China.

Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoarthritis (OA) was not clearly understood. In this study, we found that triptolide prevented OA development in a surgical destabilization of the medial meniscus (DMM) mouse model. Read More

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July 2018
9 Reads

Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets.

Inflammopharmacology 2018 Oct 27;26(5):1349-1358. Epub 2018 Jun 27.

Department of Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Oxidative stress and inflammation are intricately interlinked as aetiological factors in the context of ageing and chronic disease-related accelerated ageing. Previous research by our group has highlighted the anti-oxidant and anti-inflammatory potential of grape-derived polyphenols in the context of acute inflammation and oxidative stress. The aim here was to add to this by assessing efficacy of the treatment (acutely) to address ageing-associated cumulative pro-oxidant and pro-inflammatory changes in an in vitro model. Read More

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October 2018
9 Reads

Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats.

Inflammopharmacology 2018 Dec 13;26(6):1383-1398. Epub 2018 Jun 13.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Boswellia dalzielii is a tall tree (more than 13 m high) that produces aromatic white flowers. This plant is commonly used in indigenous medicine across Africa against diarrhea, malaria, vomiting, inflammation and arthritis. The present study focuses on the anti-inflammatory and anti-arthritis potential of methanol extract of Boswellia dalzielii (BDME). Read More

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December 2018
3 Reads

Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice.

Inflammopharmacology 2018 Jun 11. Epub 2018 Jun 11.

Posgraduate Program in Pharmaceutical Science, CCS, Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, n° 458, Bloco F6, CCS, sala 301, Itajaí, SC, CEP 88302-901, Brazil.

Objective: This study aimed to evaluate the effects of the methanol extract of Synadenium grantii Hook f. stems and its main isolated compound Query3,4,12,13-tetraacetylforbol-20-phenylacetate (1) on experimental dysmenorrhea in mice.

Methods: Female Swiss mice (n = 6-15) of 6-8 weeks old were used, selected according to the period of the estrous cycle. Read More

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June 2018
14 Reads

Neuropsychiatric clinical manifestations in elderly patients treated with hydroxychloroquine: a review article.

Inflammopharmacology 2018 Oct 9;26(5):1141-1149. Epub 2018 Jun 9.

Department of Experimental Medicine, Section of Pharmacology L. Donatelli, University of Campania 'L. Vanvitelli', Naples, Italy.

Little is known about the development of psychosis during hydroxychloroquine (HCQ) treatment, especially in elderly patients affected by rheumatic diseases, with multiple comorbidities and treatments. To summarize the available evidence on HCQ-induced psychosis in elders, we performed a literature review. Additionally, individual case safety reports sent to the European Pharmacovigilance database (EudraVigilance) with HCQ as suspected drug and related to adverse events belonging to the System Organ Class 'Psychiatric disorders' were shown. Read More

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October 2018
10 Reads

Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.

Inflammopharmacology 2018 Jun 26. Epub 2018 Jun 26.

Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Meishan Road 81, Hefei, 230032, China.

Objective: The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms.

Methods: Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation. The analgesic effect of CK was evaluated on heat-, acetic acid-, and carrageenan-induced hyperalgesia. Read More

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June 2018
4 Reads

Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.

Inflammopharmacology 2018 Jun 26. Epub 2018 Jun 26.

Department of Neurosurgery, Shanxi Coal Mine Hospital, Taiyuan, 030012, China.

Background: The study was conducted to scrutinize the outcome of isoliquiritigenin (ISL) against cerebral injury in septic mice.

Methods: The sepsis was introduced using cecal ligation and puncture (CLP) method in experimental mice. The effect of ISL was quantified using the content of brain water and blood brain barrier (BBB) permeability. Read More

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Saponins of Tribulus terrestris attenuated neuropathic pain induced with vincristine through central and peripheral mechanism.

Inflammopharmacology 2018 Jun 25. Epub 2018 Jun 25.

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, 641004, India.

The study comprises exploring the effects of saponins from Tribulus terrestris (TT) in attenuating the neuropathic pain caused by vincristine (100 μg/ml i.p.) for 10 days (in two 5 day cycles with 2 days pause). Read More

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June 2018
12 Reads

Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (NO) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats.

Inflammopharmacology 2018 Jun 22. Epub 2018 Jun 22.

Department of Pharmacology and Therapeutics, King George's Medical University, Lucknow, UP, 226003, India.

Current study was designed to evaluate protective effect of mangiferin and its interaction with low dose of nitric oxide (NO) modulators in complete Freund's adjuvant (CFA) inoculated rats. Male wistar rats (200-300 g, n = 8 per group) were used in the study. On day ''0'' of study arthritis was induced in rats by injecting 0. Read More

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June 2018
3 Reads

The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology 2018 Aug 15;26(4):899-907. Epub 2018 Jun 15.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to determine the effect of melatonin supplementation on the inflammatory markers among individuals with metabolic syndrome (MetS) and related disorders.

Methods: We searched the following databases up to March 2018: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies. Read More

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August 2018
23 Reads

Preventive effects of guanosine on intestinal inflammation in 2, 4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rats.

Inflammopharmacology 2018 Jun 15. Epub 2018 Jun 15.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Laboratorio di Fisiologia generale, Università di Palermo, Viale delle Scienze, 90128, Palermo, Italy.

Background: Guanosine, a guanine-based purine, is an extracellular signaling molecule exerting anti-inflammatory and antioxidative effects in several in vivo and in vitro injury models. We aimed to investigate its protective effects on 2, 4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rat.

Methods: Rats were divided into five groups and colitis was induced by intracolonic instillation of DNBS (15 mg/rat). Read More

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Interferon-β inhibits inflammatory responses mediators via suppression of iNOS signaling pathway in PBMCs from patients with primary Sjögren's syndrome.

Inflammopharmacology 2018 Oct 4;26(5):1165-1174. Epub 2018 Jun 4.

Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Group, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria.

Background: Primary Sjögren's syndrome (pSS) represents a chronic, systemic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands, inducing compromised secretory function and tissue destruction. Increasing evidence had revealed that inflammatory mediators, such as nitric oxide (NO) and pro-inflammatory cytokines, are critical in the development and perpetuation of pSS systemic manifestations. In our current study, we aimed to investigate the ex vivo immunomodulatory effect of interferon (IFN)-β on iNOS expression, as well as on pro-inflammatory (tumor necrosis factor (TNF)-α, interleukin (IL)-6) and immunoregulatory (IL-10) cytokine production. Read More

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October 2018
7 Reads