920 results match your criteria Inflammopharmacology [Journal]


Correction to: The kinin B and B receptors and TNFR1/p55 axis on neuropathic pain in the mouse brachial plexus.

Inflammopharmacology 2019 Apr 6. Epub 2019 Apr 6.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Unfortunately, the Fig. 7 was wrongly downloaded in the original publication. Read More

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http://dx.doi.org/10.1007/s10787-019-00590-9DOI Listing

Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.

Inflammopharmacology 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

In continuation with our previous studies on osthole, bergapten, a closely related furanocoumarin was investigated for its ameliorative effect on chemically induced neurogenic and inflammatory hyperalgesia and inflammation in mice. Chemical hyperalgesia and inflammation was induced by administration of formalin (intraplantar), acetic acid (intraperitoneal) and carrageenan (intraplantar) to different groups of animals. Pain responses were quantified and median effective dose (ED) of bergapten was calculated. Read More

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http://dx.doi.org/10.1007/s10787-019-00585-6DOI Listing
April 2019
1 Read

The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin.

Inflammopharmacology 2019 Apr 3. Epub 2019 Apr 3.

Department of Pathology, Center of Biological Sciences, State University of Londrina, Rod. Celso Garcia Cid KM480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.

Rutin is a glycone form of the flavonol quercetin and it reduces inflammatory pain in animal models. Therapy with granulocyte colony-stimulating factor (G-CSF) is known by the pain caused as its main side effect. The effect of rutin and its mechanisms of action were evaluated in a model of hyperalgesia induced by G-CSF in mice. Read More

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http://dx.doi.org/10.1007/s10787-019-00591-8DOI Listing
April 2019
1 Read

Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.

Inflammopharmacology 2019 Apr 3. Epub 2019 Apr 3.

Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Osteoarthritis (OA) is characterized by cartilage degeneration, subchondral sclerosis, and pain. Cannabinoids have well-established anti-nociceptive properties in animal models of chronic pain. The aim of this study is to evaluate the anti-nociceptive effects of synthetic cannabinoids (WIN-55,212 and HU210) and the cannabinoid-like compound palmitoylethanolamide (PEA) in rat models of OA and to assess the role of cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor α (PPARα) in mediating these effects. Read More

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http://dx.doi.org/10.1007/s10787-019-00584-7DOI Listing
April 2019
4 Reads

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways.

Inflammopharmacology 2019 Apr 2. Epub 2019 Apr 2.

People's Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.

Background: Naringenin, a flavonoid compound, has a wide variety of uses in the pharmaceutical industry for its antioxidant and anti-inflammatory potential.

Objectives: The current experiment aimed to investigate the anticancer effect of naringenin in triple-negative human breast cancer cells (MDA-MR-231) and an animal model with 7,12-dimethylbenz[a] anthracene (DMBA)-induced breast cancer in female rats to determine the mechanisms and molecular targets.

Methods: The cytotoxic effects of naringenin against MDA-MB-231 cells were assessed by MTT assay. Read More

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http://dx.doi.org/10.1007/s10787-018-00556-3DOI Listing

Are peptides a solution for the treatment of hyperactivated JAK3 pathways?

Inflammopharmacology 2019 Mar 30. Epub 2019 Mar 30.

Cell Culture Laboratory, Post-Graduation Program in Biotechnology, University of Vale do Taquari-UNIVATES, Av. Avelino Tallini, 171, Lajeado, RS, 95914-014, Brazil.

While the inactivation mutations that eliminate JAK3 function lead to the immunological disorders such as severe combined immunodeficiency, activation mutations, causing constitutive JAK3 signaling, are known to trigger various types of cancer or are responsible for autoimmune diseases, such as rheumatoid arthritis, psoriasis, or inflammatory bowel diseases. Treatment of hyperactivated JAK3 is still an obstacle, due to different sensibility of mutation types to conventional drugs and unwanted side effects, because these drugs are not absolutely specific for JAK3, thus inhibiting other members of the JAK family, too. Lack of information, in which way sole inhibition of JAK3 is necessary for elimination of the disease, calls for the development of isoform-specific JAK3 inhibitors. Read More

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http://dx.doi.org/10.1007/s10787-019-00589-2DOI Listing
March 2019
2 Reads

Sumatriptan protects against myocardial ischaemia-reperfusion injury by inhibition of inflammation in rat model.

Inflammopharmacology 2019 Mar 30. Epub 2019 Mar 30.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Ischemic heart disease is a leading cause of death on a global scale, placing major socio-economic burdens on health systems worldwide. Myocardial ischaemia and reperfusion (I/R)-induced tissue injury is associated with alteration in activity of inflammatory system and nitric oxide pathway. Sumatriptan, which is mainly used to relieve migraine headache, has recently been shown to exert anti-inflammatory properties. Read More

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http://dx.doi.org/10.1007/s10787-019-00586-5DOI Listing
March 2019
2 Reads

A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis.

Inflammopharmacology 2019 Mar 29. Epub 2019 Mar 29.

The University of Sydney, Faculty of Medicine and Health, Sydney Medical School, Sydney, NSW, 2006, Australia.

Background: The aim of the study was to assess the safety, tolerability and efficacy of palmitoylethanolamide (PEA) when dosed at 300 mg and 600 mg per day on symptoms of knee osteoarthritis.

Methods: This was a single site, comparative, double-blind placebo controlled study in adults with mild to moderate knee osteoarthritis with 111 participants randomized to receive 300 mg PEA, 600 mg PEA or placebo each day, in divided doses b.i. Read More

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http://dx.doi.org/10.1007/s10787-019-00582-9DOI Listing
March 2019
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Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline.

Inflammopharmacology 2019 Mar 28. Epub 2019 Mar 28.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Pathogenesis of the inflammatory bowel disease (IBD) involves the combination of immunological and inflammatory factors. IBD is associated with several extra-intestinal manifestations. The exact underlying bridge between the probable cardiac diseases in IBD patients is undetermined. Read More

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http://dx.doi.org/10.1007/s10787-019-00581-wDOI Listing

Limited preventive effect of prednisone on neuropsychiatric symptoms in murine systemic lupus erythematosus.

Inflammopharmacology 2019 Mar 25. Epub 2019 Mar 25.

Institute of TCM Clinical Basic Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Objective: To investigate whether glucocorticoids, the hallmark medication for systemic lupus erythematosus (SLE), could prevent the development of neuropsychiatric SLE (NPSLE).

Methods: The protective effects of prednisone on NPSLE were tested using the open field, object recognition/placement, forced swim, tail suspension, and sucrose preference tests in MRL/lpr mice. Auto-antibody titres and the weight of lymph nodes were also measured. Read More

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http://dx.doi.org/10.1007/s10787-019-00587-4DOI Listing
March 2019
2 Reads

Thymol reduces acetic acid-induced inflammatory response through inhibition of NF-kB signaling pathway in rat colon tissue.

Inflammopharmacology 2019 Mar 21. Epub 2019 Mar 21.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Aim: The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway.

Methods: Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in Wistar rats. Colitis was induced on the first day and all treatments were applied 5 days after the induction of colitis. Read More

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http://dx.doi.org/10.1007/s10787-019-00583-8DOI Listing
March 2019
1 Read

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease.

Inflammopharmacology 2019 Mar 14. Epub 2019 Mar 14.

Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, 151001, India.

Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is usually observed in AD and could implicate both beneficial or detrimental effects depending on the severity of the disease. During initial AD pathology, microglia and astrocyte activation is beneficial since they are involved in amyloid-beta clearance. Read More

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http://dx.doi.org/10.1007/s10787-019-00580-xDOI Listing
March 2019
1 Read

Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice.

Inflammopharmacology 2019 Mar 8. Epub 2019 Mar 8.

Department of Pharmacology, Meenakshi Medical College and Research Institute, Meenakshi Academy of Higher Education and Research (Deemed To Be University), Enathur, Kanchipuram, Tamilnadu, 631552, India.

Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in these effects. The antinociceptive effect of the investigated compounds in doses of 25, 50, 100, and 200 mg/kg was evaluated in male Swiss albino mice using the acetic acid test, formalin-induced nociception, and hot water tail immersion test. Read More

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http://dx.doi.org/10.1007/s10787-019-00579-4DOI Listing

Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.

Inflammopharmacology 2019 Mar 2. Epub 2019 Mar 2.

Balaji College of Pharmacy, Meerut, India.

P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity booster. The aim of the current investigation was to examine the renal protective effect of gingerol in high-fat diet/streptozotocin-induced type II diabetes mellitus in a rat model. Read More

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http://dx.doi.org/10.1007/s10787-019-00569-6DOI Listing
March 2019
2 Reads

The kinin B and B receptors and TNFR1/p55 axis on neuropathic pain in the mouse brachial plexus.

Inflammopharmacology 2019 Feb 28. Epub 2019 Feb 28.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivity induced by an intraneural (i. Read More

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http://dx.doi.org/10.1007/s10787-019-00578-5DOI Listing
February 2019
1 Read

Syk: a new target for attenuation of Helicobacter pylori-induced gastric mucosal inflammatory responses.

Inflammopharmacology 2019 Feb 28. Epub 2019 Feb 28.

Research Center, C855, Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, 110 Bergen Street, PO Box 1709, Newark, NJ, 07103-2400, USA.

The magnitude of gastric mucosal inflammatory response to H. pylori relies primarily on the extent of its key endotoxin, LPS, engagement of Toll-like receptor-4 (TLR4) and the initiation of signal transduction events converging on mitogen-activated protein kinase (MAPK) and IκB complex (IKK) cascades. These cascades, in turn, exert their control over the assembly of transcription factors, NFκB and AP1, implicated in the induction of the expression of iNOS and COX-2 proinflammatory genes. Read More

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http://dx.doi.org/10.1007/s10787-019-00577-6DOI Listing
February 2019

Pterodontic acid isolated from Laggera pterodonta suppressed RIG-I/NF-KB/STAT1/Type I interferon and programmed death-ligand 1/2 activation induced by influenza A virus in vitro.

Inflammopharmacology 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People's Republic of China.

Influenza viruses can bring about acute respiratory diseases and are a potential hazard to human health. Antiviral drugs are the main ways to control the influenza virus infection except the vaccine. In this study, the immune regulation activity of pterodontic acid isolated from Laggera pterodonta induced by influenza A virus in vitro was evaluated. Read More

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http://dx.doi.org/10.1007/s10787-019-00571-yDOI Listing
February 2019
3 Reads

Antipyretic effect of phytol, possibly via 5KIR-dependent COX-2 inhibition pathway.

Inflammopharmacology 2019 Feb 18. Epub 2019 Feb 18.

Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.

Aims: This study is aimed at the evaluation of antipyretic effect of PHY in yeast-induced hyperthermia rats. Additionally, possible mechanism of antipyretic action of PHY has been also studied by molecular docking study.

Methods: Adult male Wistar albino rats were treated with PHY at 100, 150 and 200 mg/kg in 0. Read More

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http://dx.doi.org/10.1007/s10787-019-00574-9DOI Listing
February 2019
1 Read

Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants.

Inflammopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, University of California, Los Angeles, CA, 90024, USA.

1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Read More

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http://dx.doi.org/10.1007/s10787-019-00565-wDOI Listing
February 2019

Regulatory effects of paeoniflorin-6'-O-benzene sulfonate (CP-25) on dendritic cells maturation and activation via PGE2-EP4 signaling in adjuvant-induced arthritic rats.

Inflammopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease. Dendritic cells (DCs) are one of the most powerful antigen-presenting cells, and they play an important role in RA pathogenesis. Prostaglandin E2 (PGE2) is a potent lipid mediator that can regulate the maturation and activation of DCs, but the molecular mechanisms have not been elucidated. Read More

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http://dx.doi.org/10.1007/s10787-019-00575-8DOI Listing
February 2019
1 Read

The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.

Methods: The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. Read More

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http://dx.doi.org/10.1007/s10787-019-00572-xDOI Listing
February 2019
2 Reads

Zinc and its regulators in pancreas.

Inflammopharmacology 2019 Feb 12. Epub 2019 Feb 12.

Key Laboratory of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei, 230032, China.

Studies have demonstrated that susceptibility to type 2 diabetes (T2D) is influenced by common polymorphism in the zinc transporter 8 gene SLC30A8, providing novel insight into the role of zinc in diabetes. Intriguingly, zinc participates in every step of the process, including insulin synthesis, crystallization, storage, secretion and signaling. Zinc deficiency or overload is associated with various disorders, such as diabetes, cardiovascular disease and obesity. Read More

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http://dx.doi.org/10.1007/s10787-019-00573-wDOI Listing
February 2019
6 Reads

Prevalence and current therapy in chronic liver disorders.

Inflammopharmacology 2019 Feb 8. Epub 2019 Feb 8.

TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research Institute, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.

Background: Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Read More

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http://dx.doi.org/10.1007/s10787-019-00562-zDOI Listing
February 2019
4 Reads

Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14.

Inflammopharmacology 2019 Feb 5. Epub 2019 Feb 5.

Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

We investigated effects of magnesium sulfate (MgSO) on modulating lipopolysaccharide (LPS)-macrophage binding and cluster of differentiation 14 (CD14) expression. Flow cytometry data revealed that the mean levels of LPS-macrophage binding and membrane-bound CD14 expression (mCD14) in differentiated THP-1 cells (a human monocytic cell line) treated with LPS plus MgSO (the LPS + M group) decreased by 28.2% and 25. Read More

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http://dx.doi.org/10.1007/s10787-019-00568-7DOI Listing
February 2019
3 Reads

Auto-immunity profile evaluation during different clinical manifestations of Behçet disease in Algerian patients: effect of corticosteroid treatment.

Inflammopharmacology 2019 Feb 5. Epub 2019 Feb 5.

Cytokines and NO-Synthases, Laboratory of Cellular and Molecular Biology (LBCM), Faculty of Biological Science, USTHB, PB 32, 16111, Algiers, Algeria.

Background And Aims: Behçet disease (BD) is a chronic multisystem disease. It stands at the crossroads between the auto-immunity and auto-inflammatory disorders. Our study aims to evaluate corticosteroids therapy effects on serum immunoglobulin isotypes and anti-phospholipid auto-anti-body production in Algerian BD patients with different clinical manifestations. Read More

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http://dx.doi.org/10.1007/s10787-019-00567-8DOI Listing
February 2019
3 Reads

Identification of bioactive phenolics from Porana sinensis Hemsl. stem by UPLC-QTOF-MS/MS and the confirmation of anti-inflammatory indicators using LPS-induced RAW264.7 cells.

Inflammopharmacology 2019 Jan 28. Epub 2019 Jan 28.

College of Biological Sciences and Technology, Beijing Forestry University, Qinghuadonglu No. 35, Haidian District, Beijing, 100083, China.

To characterise bioactive phenolics and confirm anti-inflammatory indicators in Porana sinensis stem, 23 phenolics were identified by UPLC-QTOF-MS/MS from crude extract (CE) prepared optimally with 80% methanol. Further fractionalisation using D101 macroporous resin resulted in predominant enrichment of total phenols and flavonoids into Fr.II. Read More

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http://dx.doi.org/10.1007/s10787-018-00558-1DOI Listing
January 2019

Anti-inflammatory properties of Liposome-encapsulated clodronate or Anti-Ly6G can be modulated by peripheral or central inflammatory markers in carrageenan-induced inflammation model.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Department of Biophysics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Overproduction of inflammatory markers by immune cells, such as macrophages and neutrophils, is one of the main reasons for many inflammatory conditions and inhibiting or suppressing of their production by cell depletion may provide new therapeutic targets or approaches to prevent a variety of inflammatory conditions. In this study, we examined the possible effects of anti-Ly6G-mediated systemic neutrophil depletion and liposome-encapsulated clodronate (LEC)-mediated systemic macrophage depletion on the inflammatory signs (thermal hyperalgesia, mechanical allodynia, oedema and fever) and measured the levels of various inflammation markers (tumour necrosis factor-α (TNF-α), interleukins (IL)-1β, IL-4, IL-10, macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) and myeloperoxidase (MPO) in paw and spinal cord tissues in carrageenan (CG)-induced hindpaw inflammation model in rats. CG injection into the paw caused inflammation characterized by redness, swelling, heat and pain hypersensitivities. Read More

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http://dx.doi.org/10.1007/s10787-019-00563-yDOI Listing
January 2019
2 Reads

Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3 cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Team Cytokines and NO Synthases-Immunity and Pathogenesis, Laboratory of Cellular and Molecular Biology (LBCM), Faculty of Biological Science, University of Sciences and Technology (USTHB), BP 32 El-Alia Bab-Ezzouar, Algiers, Algeria.

Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we evaluated the link between the iNOS/NO system and CRC progression, its relation with the host immune responses and its response to cetuximab combined with chemotherapy. Read More

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http://dx.doi.org/10.1007/s10787-019-00566-9DOI Listing
January 2019
3 Reads

The intensity of joint pain in relation to changes in serum TNFα during therapy with anti-TNFα inhibitors.

Inflammopharmacology 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Tumor necrosis factor-alpha (TNFα) inhibitors have significantly improved the outcomes of treatment for rheumatoid arthritis (RA). In the present study, we aimed to determine whether serum levels of TNFα during therapy with TNFα inhibitors do really reflect the disease activity and correspond to the intensity of pain experienced.

Materials And Methods: Thirty RA patients were examined before and after 12 weeks of routine therapy with TNFα inhibitors. Read More

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http://link.springer.com/10.1007/s10787-019-00564-x
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http://dx.doi.org/10.1007/s10787-019-00564-xDOI Listing
January 2019
5 Reads

The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45 hematopoietic cells.

Inflammopharmacology 2019 Jan 5. Epub 2019 Jan 5.

Department of Pathology, Biological Science Center, Londrina State University, Rod. Celso Garcia Cid, PR 445, Km 380, Londrina, Paraná State, 86051-990, Brazil.

Background: Naringenin is a biologically active analgesic, anti-inflammatory, and antioxidant flavonoid. Naringenin targets in inflammation-induced articular pain remain poorly explored.

Methods: The present study investigated the cellular and molecular mechanisms involved in the analgesic/anti-inflammatory effects of naringenin in zymosan-induced arthritis. Read More

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http://dx.doi.org/10.1007/s10787-018-00561-6DOI Listing
January 2019
2 Reads

Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective.

Inflammopharmacology 2019 Feb 4;27(1):39-46. Epub 2019 Jan 4.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

A number of studies have implicated cannabinoids as potent anti-inflammatory mediators. However, the exact mechanism by which cannabinoids exert these effects remains to be fully explained. The recent resurgence in interest regarding the metabolic adaptations undergone by activated immune cells has highlighted the intricate connection between metabolism and an inflammatory phenotype. Read More

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http://link.springer.com/10.1007/s10787-018-00560-7
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http://dx.doi.org/10.1007/s10787-018-00560-7DOI Listing
February 2019
3 Reads

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation.

Inflammopharmacology 2019 Feb 3;27(1):27-37. Epub 2019 Jan 3.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.

The aging population is burgeoning globally and this trend presents great challenges to the current healthcare system as the growing number of aged individuals receives procedures of surgery and anesthesia. Postoperative cognitive dysfunction (POCD) is a severe postoperative neurological sequela. Advanced age is considered as an independent risk factor of POCD. Read More

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http://dx.doi.org/10.1007/s10787-018-00559-0DOI Listing
February 2019
1 Read

Cerebrospinal inflammatory response following scorpion envenomation: role of histamine H1 and H3 receptors.

Inflammopharmacology 2019 Jan 2. Epub 2019 Jan 2.

USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria.

Background: The mechanism of the inflammatory process induced by scorpion venom in the cerebrospinal tissues has not yet been completely elucidated. Therefore, we aimed to investigate the role of histamine through its H1 and H3 receptors in this process.

Methods: Histamine H1 and H3 receptor antagonists, Hydroxyzine (10 mg/kg) and Betaserc (20 mg/kg), respectively, were administered by intraperitoneal route to mice 1 h before subcutaneous envenomation with a subletal dose (0. Read More

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http://dx.doi.org/10.1007/s10787-018-00553-6DOI Listing
January 2019
5 Reads

International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.

Inflammopharmacology 2019 Jan 2. Epub 2019 Jan 2.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box: 14155-6446, Tehran, Iran.

Background: The oral administration of drug β-D-mannuronic acid (M2000) showed a potent therapeutic effect in phase I/II study in rheumatoid arthritis (RA) patients. Here, our aim is to assess the efficacy and safety of this new drug in RA patients under a multinational, randomized placebo-controlled phase III clinical trial.

Method: Patients (n = 288) with active disease at baseline and inadequate response to conventional drugs were randomly allocated to three groups; (1) receiving mannuronic acid at a dose of two capsules (500 mg) per day orally for 12 weeks, (2) placebo-controlled, and (3) conventional. Read More

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http://link.springer.com/10.1007/s10787-018-00557-2
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http://dx.doi.org/10.1007/s10787-018-00557-2DOI Listing
January 2019
12 Reads

Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Centre for Integrated Preclinical Drug Development, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.

Human immuno-deficiency virus (HIV) associated sensory neuropathy (SN) is a frequent complication of HIV infection. It is extremely difficult to alleviate and hence the quality of life of affected individuals is severely and adversely impacted. Stavudine (d4T) is an antiretroviral drug that was widely used globally prior to 2010 and that is still used today in resource-limited settings. Read More

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http://dx.doi.org/10.1007/s10787-018-00551-8DOI Listing
January 2019
3 Reads

Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research 151, VAMC, 1030 Jefferson Ave, Memphis, TN, 38104, USA.

In this study, we evaluated the hypothesis that immunonanosomes carrying the drug [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1) will help in reducing nuclear factor-kappaB (NF-κB)-associated inflammation in porcine chondrocytes against tumor necrosis factor-alpha (TNF-α)-induced stress. The nanosomes were tagged with monoclonal anti-type II collagen (MabCII) antibody to specifically target the exposed type II collagen in cartilage matrix. TPCA-1 at a concentration of 10 µM significantly reduced expression of the matrix-degrading enzyme, Matrix metalloproteinase-13 (MMP-13) and blocked the p65 nuclear translocation. Read More

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http://dx.doi.org/10.1007/s10787-018-0542-5DOI Listing
January 2019
2 Reads

Proteoglycans isolated from the bramble shark cartilage show potential anti-osteoarthritic properties.

Inflammopharmacology 2019 Feb 1;27(1):175-187. Epub 2019 Jan 1.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Osteoarthritis (OA) causes articular cartilage destruction, initiating pain and inflammation in the joints, resulting in joint disability. Medications are available to manage these symptoms; however, their effects on the disease progression are limited. Loss of proteoglycans (PGs) was reported to contribute articular cartilage destruction in OA. Read More

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http://dx.doi.org/10.1007/s10787-018-00554-5DOI Listing
February 2019
1 Read

Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.

Background: Carfilzomib (CFZ), a proteasome inhibitor approved by the FDA to treat multiple myeloma, may cause nephrotoxicity.

Hypothesis: Rutin is a bioflavonoid with antioxidant properties. We aimed to examine whether rutin protects the kidney from CFZ-induced nephrotoxicity. Read More

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http://link.springer.com/10.1007/s10787-018-0550-5
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http://dx.doi.org/10.1007/s10787-018-0550-5DOI Listing
January 2019
4 Reads

Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.

Inflammopharmacology 2019 Feb 1;27(1):47-56. Epub 2019 Jan 1.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, Sichuan Province, China.

Background: Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms of resveratrol in patients with gout. Read More

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http://dx.doi.org/10.1007/s10787-018-00555-4DOI Listing
February 2019
5 Reads

Polyphenol-associated oxidative stress and inflammation in a model of LPS-induced inflammation in glial cells: do we know enough for responsible compounding?

Inflammopharmacology 2019 Feb 13;27(1):189-197. Epub 2018 Dec 13.

Department Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Cyanidin and chlorogenic acid are polyphenols from plant origin that are present in many common fruits, particularly in berries. To corroborate the protective or detrimental effects of both compounds from a neuro-inflammatory perspective, in vitro experiments were carried out in human astrocytes (U-373). Astrocytes were pre-treated with a range of concentrations of either cyanidin, chlorogenic acid or a combined treatment for a period of 30 min, before exposure to Escherichia coli lipopolysaccharide (LPS) challenge for 23. Read More

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http://dx.doi.org/10.1007/s10787-018-0549-yDOI Listing
February 2019
4 Reads

Berberis lycium Royle fruit extract mitigates oxi-inflammatory stress by suppressing NF-κB/MAPK signalling cascade in activated macrophages and Treg proliferation in splenic lymphocytes.

Inflammopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Pharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, HP, 176061, India.

Although Berberis plant species have been advocated as immune modulators, information regarding their mechanism(s) of action is limited. Therefore, in the present study we assessed the efficacy of Berberis lycium Royle fruit extract (BLFE) in the attenuation of lipopolysaccharide (LPS)-induced oxi-inflammatory aggravation and concanavalin A (Con-A)-induced proliferation in murine peritoneal macrophages and lymphocytes, respectively. BLFE strongly suppressed production of the oxidative and inflammatory effector molecules nitric oxide (NO), reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS), inflammatory cytokines (TNF-α/IL-6/IL-1β/IFN-γ) as well as chemokines (MCP-1 and RANTES), with a concomitant enhancement in heme oxygenase-1 (HO-1) and IL-10 levels. Read More

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http://link.springer.com/10.1007/s10787-018-0548-z
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http://dx.doi.org/10.1007/s10787-018-0548-zDOI Listing
December 2018
13 Reads

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model.

Inflammopharmacology 2018 Nov 23. Epub 2018 Nov 23.

Department of Zoology, MMV, Banaras Hindu University, Varanasi, 221005, India.

Objective: Bacterial infections can exacerbate asthmatic inflammation depending on lipopolysaccharide (LPS) composition, the outermost component of cell wall, its exposure timings as well as host's immune status. In present study, Balb/c mice were exposed to antigen (ovalbumin) and LPS simultaneously to establish an asthmatic model. Curcumin (diferuloylmethane), well known for its anti-inflammatory potential, was administered through intranasal route 1 h before LPS and OVA (ovalbumin) exposure to evaluate its efficacy against airway structural changes. Read More

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http://dx.doi.org/10.1007/s10787-018-0544-3DOI Listing
November 2018
17 Reads

Stress as an immunomodulator: liver X receptors maybe the answer.

Inflammopharmacology 2019 Feb 22;27(1):15-25. Epub 2018 Nov 22.

Institut de radioprotection et de sûreté nucléaire, Direction de la radioprotection de l'homme, IRSN, Fontenay-aux-Roses Cedex, France.

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Read More

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http://dx.doi.org/10.1007/s10787-018-0546-1DOI Listing
February 2019
34 Reads

Inhibitory effects of Clematis orientalis aqueous ethanol extract and fractions on inflammatory markers in complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

Laboratory Rashid Latif College of Pharmacy, Lahore, Pakistan.

Clematis orientalis Linn has long been used as ethnopharmacy for the treatment of arthritis. This study is intended to evaluate the curative efficacy of Clematis orientalis in treating polyarthritis in rats. Aqueous ethanolic extract and fractions (hexane, butanol and aqueous) were administered orally at 200 mg/kg for 28 days after CFA immunization. Read More

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http://dx.doi.org/10.1007/s10787-018-0543-4DOI Listing
November 2018
3 Reads

Plantago squarrosa Murray extracts inhibit the growth of some bacterial triggers of autoimmune diseases: GC-MS analysis of an inhibitory extract.

Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.

School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, QLD, 4111, Australia.

Ankylosing spondylitis, multiple sclerosis, rheumatoid arthritis and rheumatic fever are autoimmune inflammatory diseases that may be triggered in genetically susceptible individuals by specific bacterial pathogens. Inhibiting the growth of these bacteria with high antioxidant plant extracts may inhibit the aetiology of these diseases, as well as inhibiting the later phase symptoms. P. Read More

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http://link.springer.com/10.1007/s10787-018-0547-0
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http://dx.doi.org/10.1007/s10787-018-0547-0DOI Listing
November 2018
23 Reads

Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.

Inflammopharmacology 2018 Nov 13. Epub 2018 Nov 13.

Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Ministry of Education, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.

The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Read More

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http://link.springer.com/10.1007/s10787-018-0545-2
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http://dx.doi.org/10.1007/s10787-018-0545-2DOI Listing
November 2018
22 Reads

Intraarticular injection of dexamethasone promotes bone erosion in collagen-induced arthritis in mice through up-regulation of RANKL expression.

Inflammopharmacology 2018 Oct 20. Epub 2018 Oct 20.

Department of Rheumatology, Jiangsu Province Hospital, Nanjing Medical University First Affiliated Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.

Background: Dexamethasone (DEX) is an effective therapeutic option commonly used in the treatment of many inflammatory diseases. However, DEX could impair proliferation or differentiation of osteoblasts, suggesting a pivotal role of DEX in bone destruction.

Objective: To investigate whether intraarticular injection of DEX could exacerbate bone erosion during CIA development. Read More

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http://link.springer.com/10.1007/s10787-018-0541-6
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http://dx.doi.org/10.1007/s10787-018-0541-6DOI Listing
October 2018
8 Reads

Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus.

Inflammopharmacology 2019 Feb 20;27(1):5-13. Epub 2018 Oct 20.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP. Read More

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http://dx.doi.org/10.1007/s10787-018-0540-7DOI Listing
February 2019
3 Reads

The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial.

Inflammopharmacology 2019 Feb 16;27(1):67-76. Epub 2018 Oct 16.

Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP). Read More

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http://link.springer.com/10.1007/s10787-018-0539-0
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http://dx.doi.org/10.1007/s10787-018-0539-0DOI Listing
February 2019
2 Reads