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Chem Biol Interact 2022 Jun 22:110026. Epub 2022 Jun 22.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Background: and Purpose: Inflammatory Bowel Disease (IBD) is a persistent bio-psychological disorder with the absence of actual pathological reason. Association between IBD and isotretinoin has been reported by many human and in vitro studies. However, in this study, our focus is on finding the causal relationship between IBD and isotretinoin for the development of a new animal model. Read More

Sci Total Environ 2022 Jun 22:156884. Epub 2022 Jun 22.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The potential health effects of microplastics (MPs) have become a public concern due to their ubiquitous in the environment and life. Numerous studies have demonstrated that a high dose of MPs can adversely affect gastrointestinal health. However, few studies have focused on the impact of microplastics on patients' health with respect to gastrointestinal diseases. Read More

Immunology 2022 Jun 25. Epub 2022 Jun 25.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Mineralocorticoid receptor (MR) is a classic nuclear receptor and an effective drug target in the cardiovascular system. The function of MR in immune cells such as macrophages and T cells has been increasingly appreciated. The aim of this study was to investigate the function of Treg MR in the process of inflammatory bowel disease (IBD). Read More

Dig Dis Sci 2022 Jun 25. Epub 2022 Jun 25.

Division of Pediatric Gastroenterology and Nutrition, Department of Paediatrics, University of Alberta, ECHA, Room 4-577, 11405 87 Ave, Edmonton, AB, T6G 1C9, Canada.

To review and discuss recent findings on the associations between pediatric/early-life exposures to ambient air pollution and the risk of pediatric-onset inflammatory bowel diseases (IBD). A scoping review was conducted using the Peters Micah et al. framework. Read More

Inflamm Bowel Dis 2022 Jun 25. Epub 2022 Jun 25.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

J Crohns Colitis 2022 Jun 25. Epub 2022 Jun 25.

Genome Biol 2022 Jun 24;23(1):136. Epub 2022 Jun 24.

Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.

Background: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endotoxin tolerance, profiling the coding and non-coding transcriptome, chromatin accessibility and epigenetic modifications.

Results: We describe the spectrum of enhancers under acute and tolerance conditions and the regulatory networks between these enhancers and biological processes including gene expression, splicing regulation, transcription factor binding and enhancer RNA signatures. Read More

BMC Gastroenterol 2022 Jun 24;22(1):309. Epub 2022 Jun 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Xitun Dist., Taichung City, 40705, Taiwan.

Background: Cecal ulcers are sometimes encountered in asymptomatic individuals. Their clinical outcomes and management recommendations remain uncertain.

Methods: Asymptomatic patients who underwent a colonoscopic exam for colon cancer screening were retrospectively reviewed from July 2009 to November 2016. Read More

Hum Pathol 2022 Jun 21. Epub 2022 Jun 21.

Immune Profiling and Cancer Group, Faculty of Medicine, Mater Research Institute - the University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4011, Australia. Electronic address:

The presence of IgA- and IgM-specific autoantibody (AAb) isotypes and their relationship to p53 tissue expression patterns are not well understood. This study aims to investigate the clinical utility of the anti-p53 AAb isotypes and tissue positivity in colorectal cancer (CRC). We analysed anti-p53 IgG, IgM, and IgA AAbs in sera of 99 CRC patients and 99 non-cancer control subjects. Read More

Clinics (Sao Paulo) 2022 Jun 21;77:100069. Epub 2022 Jun 21.

Department of Rheumatology and Immunology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, China. Electronic address:

Objectives: M1 macrophage polarization and phenotype in Inflammatory Bowel Disease (IBD) are common biological responses.

Method: Herein, IBD mice models were constructed and macrophages were derived.

Results: It was discovered that microRNA-146b (miR-146b) was downregulated in IBD mice and Lipopolysaccharide (LPS)-induced macrophages. Read More

Drug Dev Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Gastroenterology, Taizhou First People's Hospital, Taizhou, Zhejiang, China.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may progress to colorectal cancer in severe cases. Carnitine palmitoyltransferase-1A (CPT1A) has been reported to be upregulated in colorectal cancer. This paper aims to explore the role of CPT1A in UC and its pathogenesis. Read More

PLoS One 2022 24;17(6):e0270297. Epub 2022 Jun 24.

Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Introduction: Inflammatory bowel disease is a relapsing chronic gastrointestinal inflammatory disease. Idiopathic pulmonary fibrosis is a rare but serious extraintestinal pulmonary manifestation of inflammatory bowel disease. However, the relationship between these two conditions is unclear. Read More

Inflamm Bowel Dis 2022 Jun 24. Epub 2022 Jun 24.

Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada.

Inflamm Bowel Dis 2022 Jun 24. Epub 2022 Jun 24.

IBD Referral Center, Gastroenterology Department, Careggi University Hospital, Florence, Italy.

Micro-RNAs (miRNAs) are noncoding RNAs usually 24-30 nucleotides long that play a central role in epigenetic mechanisms of inflammatory diseases and cancers. Recently, several studies have assessed the involvement of miRNAs in the pathogenesis of inflammatory bowel disease (IBD) and colitis-associated neoplasia. Particularly, it has been shown that many members of miRNAs family are involved in the pathways of inflammation and fibrogenesis of IBD; therefore, their use as inflammatory and fibrosis biomarkers has been postulated. Read More

Inflamm Bowel Dis 2022 Jun 24. Epub 2022 Jun 24.

Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, AB, T6G 2X8, Canada.

The vermiform appendix is generally considered a redundant organ, but recent evidence suggests that the appendix could contribute to the pathogenesis of inflammatory bowel diseases, in particular ulcerative colitis (UC), and may even have a therapeutic role; however, mechanisms of the appendix involvement remain unclear. Here, we highlight current evidence on the link between the appendix and UC and consider plausible therapeutic implications. A literature search was conducted using PubMed and PubMed Central from inception to Nov 2021 using the terms "Appendix", "UC", "Appendix & UC," "Appendectomy", and "Peri-appendicular patch," including only articles published in English. Read More

Dig Dis Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Immune checkpoint inhibitors (ICPIs) have revolutionized cancer therapy, although immune-related adverse events (irAEs) remain a serious issue. The clinical characteristics of colitis induced by ICPIs are very similar to inflammatory bowel disease. Recently, cluster of differentiation 8 positive (CD8) lymphocyte infiltration into organs has been associated with the onset of irAEs. Read More

Aliment Pharmacol Ther 2022 Jul;56(2):371

IRCCS Ospedale San Raffaele, Gastroenterology and Endoscopy and Università Vita e Salute San Raffaele, Milan, Italy.

Aliment Pharmacol Ther 2022 Jul;56(2):370

Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, China.

Aliment Pharmacol Ther 2022 Jul;56(2):345-346

Crohn's and Colitis Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Aliment Pharmacol Ther 2022 Jul;56(2):353-354

AW Morrow Gastroenterology and Liver Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Aliment Pharmacol Ther 2022 Jul;56(2):355-356

Department of Medicine, Queen Mary Hospital, Hong Kong, China.

Fetal Pediatr Pathol 2022 Jun 24:1-10. Epub 2022 Jun 24.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Background: A small subset of cases of inflammatory bowel disease (IBD) occurs as a result of single gene defects, and typically occurs in young or very young pediatric patients, referred to as "monogenic very-early onset IBD (VEO-IBD)". The gene variants leading to monogenic VEO-IBD are often associated with primary immunodeficiency syndromes.

Case Report: A six year-old girl presented to our gastroenterology clinic with LRBA deficiency with a heterozygous mutation at c. Read More

Ann Ital Chir 2022 Jun 15;11. Epub 2022 Jun 15.

Crohn's Disease (CD) refers to a chronic transmural bowel inflammation affecting a range between 5 and 15 per 100,000 person-years worldwide 1. In patients with stricturing CD, the transmural pattern of inflammation may trigger the development of sinus tracts able to connect to other tissues, leading to the formation of fistulas or abscesses 2. Intra-psoas abscesses are rare, affecting between 0. Read More

Drug Des Devel Ther 2022 17;16:1897-1913. Epub 2022 Jun 17.

Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.

Upadacitinib is a selective small molecule that inhibits Janus kinase (JAK) type 1. This molecule is administrated orally and is currently approved for the treatment of rheumatoid arthritis, atopic dermatitis, and psoriatic arthritis. Upadacitinib has been approved by the United States Food and Drug Administration for the induction and maintenance therapy of moderate-to-severe ulcerative colitis (UC) and is under investigation by the European Medicines Agency. Read More

Front Nutr 2022 7;9:899829. Epub 2022 Jun 7.

Health Sciences Institute, China Medical University, Shenyang, China.

Clinical cases and animal experiments show that high-fat (HF) diet is involved in inflammatory bowel disease (IBD), but the specific mechanism is not fully clear. A close association between long-term HF-induced obesity and IBD has been well-documented. However, there has been limited evaluation of the impact of short-term HF feeding on the risk of intestinal inflammation, particularly on the risk of disrupted metabolic homeostasis. Read More

Biologics 2022 17;16:67-83. Epub 2022 Jun 17.

Department of Medicine - Division of Gastroenterology, Houston Methodist, Houston, TX, USA.

Several biologic therapies have been approved for enteric diseases. We evaluate each biologic's role based on their mechanism of action in treating these conditions. This review examines data on efficacy and safety, as well as considerations for using these therapies in clinical practice in inflammatory bowel diseases, enteric infections-specifically colitis-and potentially in the increasingly prevalent disorder of eosinophilic esophagitis. Read More

Cureus 2022 May 21;14(5):e25177. Epub 2022 May 21.

Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore, PAK.

Pyoderma gangrenosum (PG) is a very rare, non-infectious, progressive inflammatory condition falling under the umbrella of neutrophilic dermatoses. It is an ulcerative condition with a wide variety of cutaneous manifestations and multiple clinical variants (classic ulcerative, pustular, bullous, and superficial granulomatous). Additionally, owing to similar patterns of mucocutaneous ulceration, it has certain overlaps with other neutrophilic diseases frequently observed in clinical practice. Read More

Pharmaceutics 2022 Jun 11;14(6). Epub 2022 Jun 11.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.

Due to ethical and practical reasons, a knowledge gap exists on the pharmacokinetics (PK) of inflammatory bowel disease (IBD)-related drugs in pregnant women with IBD. Before evidence-based dosing can be proposed, insight into the PK has to be gained to optimize drug therapy for both mother and fetus. This systematic review aimed to describe the effect of pregnancy and IBD on the PK of drugs used for IBD. Read More

Pharmaceutics 2022 May 31;14(6). Epub 2022 May 31.

Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.

Gut modulation by multi-strain probiotics (MSPs) is considered an effective strategy for treating inflammatory bowel disease (IBD). The combination of nanomaterial-based MSPs can improve their viability and resistance and can allow their targeted release in the gastrointestinal tract to be achieved. Thus, our aim is to investigate the prospective role of MSP integration into nanomaterials (MSPNPs) and the underlying molecular mechanisms supporting their application as an alternative therapy for IBD using a colitis rat model. Read More

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Diet plays an important role in the development and progression of inflammatory bowel disease (IBD, comprising Crohn's disease (CD) and ulcerative colitis (UC)). However, little is known about the extent to which different diets reflect inflammation in IBD beyond measures such as faecal calprotectin or C-reactive protein. In this study, we aimed to unravel associations between dietary patterns and circulating inflammatory proteins in patients with IBD. Read More