636,617 results match your criteria Inflammation & Allergy - Drug Targets[Journal]


Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan.

J Innate Immun 2018 Dec 17:1-17. Epub 2018 Dec 17.

Laboratório de Farmacologia Celular e Molecular, Universidade do Estado do Rio de Janeiro, Rio de Janeiro,

Exposition of neutrophils (polymorphonuclear neutrophils, PMNs) to bacterial products triggers exacerbated activation of these cells, increasing their harmful effects on host tissues. We evaluated the possibility of interfering with the classic immune innate responses of human PMNs exposed to bacterial endotoxin (lipopolysaccharide, LPS), and further stimulated with bacterial formyl peptide (N-formyl-methionine-leucine-phenylalanine, fMLP). We showed that the low- molecular-weight fucoidan (LMW-Fuc), a polysaccharide extracted from brown algae, attenuated the exacerbated activation induced by fMLP on LPS-primed PMNs, in vitro, impairing chemotaxis, NET formation, and the pro-survival and pro-oxidative effects. Read More

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December 2018

Controllable fabrication of hydroxybutyl chitosan/oxidized chondroitin sulfate hydrogels by 3D bioprinting technique for cartilage tissue engineering.

Biomed Mater 2018 Dec 17. Epub 2018 Dec 17.

Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, CHINA.

Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult to achieve. The aim of this study is to fabricate a biocompatible cell-laden hydrogel with a designable structure. Read More

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December 2018

Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol.

Biomed Pharmacother 2018 Dec 14;110:844-849. Epub 2018 Dec 14.

The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310023, Zhejiang, China. Electronic address:

Background Hyperuricemia is a recognised risk factor for the development of nonalcoholic fatty liver disease (NAFLD). This study aims to investigate the therapeutic effect of resveratrol (RES) on the treatment of hyperuricemia-related NAFLD in rats and the underlying mechanisms. Methods NAFLD with hyperuricemia was induced in rats using high-yeast high-fat diet containing potassium oxonate. Read More

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December 2018

Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More

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December 2018

Macrophage functionality and homeostasis in response to oligoethyleneglycol-coated IONPs: impact of a dendritic architecture.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Université de Strasbourg, CNRS, CAMB UMR 7199, F-67000 Strasbourg, France.

The engineering of iron oxide nanoparticles (IONPs) for biomedical use has received great interest over the past decade. In the present study we investigated the biocompatibility of IONPs grafted with linear (2P) or generation 1 (2PG1) or 2 (2PG2) dendronized oligoethyleneglycol units in THP-1-derived macrophages. To evaluate IONP effects on cell functionality and homeostasis, mitochondrial function (MTT assay), membrane permeability (LDH release), inflammation (IL-8), oxidative stress (reduced glutathione, GSH), NLRP3-inflammasome activation (IL-1β) and nanoparticle cellular uptake (intracellular iron content) were quantified after a 4-h or 24-h cell exposure to increasing IONP concentrations (0-300 µg Fe/mL). Read More

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December 2018
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Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria s/n, Ciudad de México, 04650, Mexico. Electronic address:

Rheumatoid arthritis (RA) is an autoimmune disease that causes physical disability in people worldwide. Despite progress made in RA treatment in the past decade, new drugs with high efficacy but few long-term adverse effects are still needed. This study focused on evaluating the therapeutic potential of α-mangostin on established collagen-induced arthritis (CIA) in DBA/1J mice. Read More

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December 2018

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland. Electronic address:

No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and phosphopeptide expression levels from human temporal cortical samples, with varying degree of AD-related pathology. This approach highlighted fluctuation in synaptic and mitochondrial function as the earliest pathological events in brain samples with AD-related pathology. Read More

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December 2018

Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Kentucky Spinal Cord Injury Research Center, University of Louisville, School of Medicine, 511 S. Floyd St., MDR 616, Louisville, KY 40202, USA; Department of Anatomical Science & Neurobiology, University of Louisville, School of Medicine, 511 S. Floyd St., MDR 616, Louisville, KY 40202, USA.

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following spinal cord injury (SCI). Using a thoracic contusion model in C57Bl/6 wild type female mice, SCI led to significant shifts in the gut bacterial community including an increase in the phylum Proteobacteria, which consists of endotoxin-harboring, gram-negative bacteria. Read More

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December 2018

Alginate/Chitosan microparticles for gastric passage and intestinal release of therapeutic protein nanoparticles.

J Control Release 2018 Dec 14. Epub 2018 Dec 14.

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 950 Atlantic Dr. NW, Atlanta, GA 30332, USA. Electronic address:

Enzymes with intracellular activity have significant potential to treat diseases. Protein nanoparticles (NPs) considerably enhance intracellular delivery of enzymes. We have previously shown that a Salmonella effector enzyme, AvrA, delivered by NPs is capable of modulating inflammatory signals in a murine dextran sulfate sodium (DSS) colitis model. Read More

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December 2018

IgE blockade in autoimmunity: Omalizumab induced remission of bullous pemphigoid.

Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia; Institute of Immunology and Infectious Diseases (IIID), Murdoch University, Murdoch, WA 6150, Australia. Electronic address:

Bullous pemphigoid (BP) is a blistering dermopathy and a prototypic antibody-mediated autoimmune disease. Detection of IgG autoantibodies against hemidesmosomal proteins BP180 and/or BP230 are diagnostic and levels can correlate with disease activity. Therapies include corticosteroids and oral immunosuppressants, while intravenous immunoglobulin and rituximab are reserved for treatment resistant cases. Read More

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December 2018
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Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, RAS, 4 Kosygin St., Moscow, 119991, Russia; Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya St., Moscow, 119991, Russia; Institute of Photonic Technologies, Research Center "Crystallography and Photonics", RAS, 2 Pionerskaya st., Troitsk, Moscow, 142190, Russia.

We have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate - tryptophan - in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively. The presence of the photosensitizer and Pluronic F127 has been shown to have a negligible effect on the rate of photodestruction of mono- and dinuclear DNIC-TL, taking into account the changing DNIC-TL and PD concentrations in the photoexcitation conditions. Read More

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December 2018
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Mast Cell Granules: Modulating adaptive immune response remotely.

J Allergy Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Immune Imaging Program Centenary Institute, Faculty of Medicine and Health The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health University of Sydney, NSW 2006, Australia; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

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December 2018
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Dioclea violacea lectin ameliorates inflammation in the temporomandibular joint of rats by suppressing intercellular adhesion molecule-1 expression.

Biochimie 2018 Dec 14. Epub 2018 Dec 14.

Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Área de Imunologia, Campinas, Brazil. Electronic address:

Inflammation of temporomandibular joint (TMJ) tissues are the most common cause of pain conditions associated with temporomandibular disorders (TMDs). After a tissue and/or neural damage, the inflammatory response is characterized by plasma extravasation and leukocytes infiltration in the TMJ tissues, which in turn, release inflammatory cytokines cascades responsible for inflammatory pain. Lectins are glycoproteins widely distributed in nature that may exhibit anti-inflammatory properties. Read More

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December 2018

Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression.

Am J Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Northwestern University, Department of Psychiatry and Behavioral Sciences.

Background: While perinatal depression is one of the most common complications of pregnancy, there is an insufficient understanding of the mechanistic underpinnings of disease. While an association between peripheral inflammatory cytokines and major depressive disorder has been demonstrated, cytokines cannot freely cross the blood brain barrier and thus they give little insight into alternations in brain function. As the brain is in direct communication with the cerebrospinal fluid (CSF), assessment of inflammation in the CSF may be more directly related to the biologic markers of affective change. Read More

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December 2018

Association between Serum Resistin, Adiposity Measures and Inflammatory Makers in Women Without Cardiovascular Diseases.

Chem Phys Lipids 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Aims: The convergence of obesity and inflammation in the pathogenesis of cardiovascular diseases (CVD) has been recognized over the past decade. Resistin has emerged as a novel secreted protein with links to both insulin resistance and inflammation. We aimed to investigate the relationship between changes in serum resistin levels with metabolic parameters, including obesity and inflammatory markers in women free of CVD. Read More

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December 2018

Analysing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Proteomics 2018 Dec 17:e1800176. Epub 2018 Dec 17.

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host-microorganism relationship or they may even serve as useful biomarkers for CRC. Read More

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December 2018

Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Acanthamoeba profilin elicits allergic airway inflammation in mice.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006979. Epub 2018 Dec 17.

Department of Parasitology School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do, South Korea.

Background: In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13-15 kDa Acanthamoeba unknown allergen.

Objective: We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. Read More

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December 2018
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Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.

PLoS One 2018 17;13(12):e0208553. Epub 2018 Dec 17.

Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.

Introduction: Studies on the associations between phthalate exposures and respiratory outcomes are limited. We investigated the association of phthalates exposure with pulmonary function and airway inflammation in asthmatic children.

Methods: Fifty-six children with asthma living in Seoul Metropolitan Area, Korea aged 6-16 years were enrolled. Read More

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December 2018

Detection of myocardial inflammation by 18F-FDG-PET/CT in patients with systemic sclerosis without cardiac symptoms: a pilot study.

Clin Exp Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Nuclear Medicine, University of Szeged, Hungary.

Objectives: Primary cardiac manifestation is a common complication of systemic sclerosis (SSc) with poor prognosis. The aim of the current study was to detect potential myocardial inflammation present in asymptomatic SSc patients by 18F-FDG-PET/CT and to investigate its relationship with early signs of myocardial dysfunction as detected by 2D speckle tracking echocardiography (2DSTE).

Methods: Sixteen consecutive patients with SSc and 9 control patients without clinical evidence of cardiac involvement were enrolled in the study. Read More

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December 2018
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The effect of biologic agents on bone homeostasis in chronic inflammatory rheumatic diseases.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Osteoporosis (OP) and increased fracture risk are widely observed comorbidities in chronic inflammatory rheumatic diseases (CIRDs). Improved knowledge of the immune/inflammatory pathways, which characterise the pathophysiology of rheumatoid arthritis (RA) and seronegative spondyloarthropathies (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have provided the link between inflammation and bone loss, via a complex network of bone cells, T and B cells, pro-inflammatory cytokines such as TNF-α, IL1, IL6, IL17, IL23, costimulator molecules, signalling pathways including both RANKL/RANK/OPG and Wnt signallings. The complex osteoimmunologic network in CIRDs suggested that the powerful anti-inflammatory activity of biologic drugs, beyond the control of the disease, was likely to reduce OP and fracture risk. Read More

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November 2018

An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis.

J Clin Periodontol 2018 Dec 17. Epub 2018 Dec 17.

Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, Massachusetts, USA.

Background: Historically, inflammatory periodontal diseases (gingivitis and periodontitis) have been recognized as being primarily of bacterial origin. Bacteria are necessary for disease development, but the presence of specific bacteria does not guarantee progression to periodontitis. Periodontitis is a multifactorial disease; specific bacteria are associated with disease, but may not be the target of treatment. Read More

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December 2018

Hypercholesterolemia and hypertriglyceridemia as biochemical markers of disease in companion rabbits.

Vet Clin Pathol 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Microbiology and Immunology, University of California-Davis School of Veterinary Medicine, Davis, California.

Background: Inflammation has important effects on lipid metabolism, but the relationship between hyperlipidemia, inflammation, and disease remains unknown in rabbits. While rabbits are sensitive to dietary hypercholesterolemia, the etiology of hyperlipidemia when fed non-atherogenic diets is uncertain.

Objectives: This study aimed to determine the association between hypercholesterolemia and patient characteristics, diseases, and select CBC and biochemistry analytes in rabbits, and to measure plasma lipoprotein lipid fractions in rabbits with inflammatory and other diseases. Read More

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December 2018

Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.

J Neurochem 2018 Dec 17. Epub 2018 Dec 17.

Translational Health Science and Technology Institute, Faridabad, India.

MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs overexpressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JEV-infected microglial cells through extracellular vesicles. The let-7a/b were previously reported to modulate inflammation in microglial cells through Toll-like receptor 7 (TLR7) pathways; though their role in accelerating JEV pathogenesis remain unexplored. Read More

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December 2018

Non-steroidal anti-inflammatory drugs increase MRP4 expression in an endometriotic epithelial cell line in a PPARa dependent manner.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8487-8496

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Objective: Endometriosis is a debilitating disease characterized by chronic inflammation. The transporter multidrug resistance-associated protein 4 (MRP4/ABCC4) is expressed in human endometrial tissue; it is overexpressed in ectopic endometrial tissue, and is modulated by the anti-inflammatory lipid Lipoxin A4 (LXA4). Recently, it was demonstrated that aspirin induces platelet MRP4 over-expression, through genomic modulation in megakaryocytes. Read More

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December 2018

NLRP12 promotes host resistance against Pseudomonas aeruginosa keratitis inflammatory responses through the negative regulation of NF-κB signaling.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8063-8075

Department of Laboratory, Longhua District Central Hospital, Longhua District, Shenzhen, China.

Objective: To investigate the role of NLRP12 in regulating Pseudomonas aeruginosa (P. aeruginosa) keratitis.

Materials And Methods: Real-Time-PCR and Western blot were performed to measure the NLRP12 level in corneas and bone marrow-derived macrophages (BMDMs) of C57BL/6 (B6) mice. Read More

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December 2018

Minimum Information about an Uncultivated Virus Genome (MIUViG).

Nat Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. Read More

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December 2018
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Comparison of Spectral Domain Optical Coherence Tomography (SD OCT) Findings with Laser Flare Photometry (LFP) Measurements in Behçet's Uveitis.

Ocul Immunol Inflamm 2018 Dec 17:1-6. Epub 2018 Dec 17.

b Ophthalmology, Faculty of Medicine , Ankara University , Ankara , Turkey.

Purpose: This study aims to compare the spectral domain optical coherence tomography (SD OCT) findings and laser flare photometry (LFP) measurements in Behçet's disease (BD).

Methods: This study was composed of 4 groups as follows: "Group 1: Healthy volunteers, Group 2: Volunteers with BD and no eye involvement, Group 3: Patients with active uveitis with BD, Group 4: Patients with BD in quiescent phase of uveitis". Laser Flare Photometry (Kowa FM-600, Kowa Acculas, San Jose, CA, USA), SD-OCT and Enhanced Depth Imaging protocol (EDI) (Spectralis®, Heidelberg Engineering Inc. Read More

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December 2018

Measuring disease activity and response to treatment in rheumatoid arthritis.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

b Department of Musculoskeletal Biology , Institute of Ageing and Chronic Disease, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital , Liverpool.

Introduction: Effective treatment of rheumatoid arthritis (RA) requires suppression of the underlying inflammation. Measurement of such inflammation, the disease activity, is mandatory to target treatment and maximize outcomes. However, this is not as straightforward as it may seem. Read More

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December 2018
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4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.

ChemMedChem 2018 Dec 17. Epub 2018 Dec 17.

Laboratory for Medicinal Chemistry, Department of Pharmaceutics (FFW), Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Invariant natural killer T-cells (iNKT) are a glycolipid-responsive subset of T-lymphocytes that fulfill a pivotal role in the immune system. The archetypical synthetic glycolipid, α-galactosylceramide (α-GalCer), whose molecular framework is inspired by a group of amphiphilic natural products, remains the most studied antigen for iNKT-cells. Nonetheless, the potential of α-GalCer as an immunostimulating agent is compromised by the fact that this glycolipid elicits simultaneous secretion of Th1- and Th2-cytokines. Read More

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December 2018

Vitamin E: Regulatory Role on Signal Transduction.

Authors:
Jean-Marc Zingg

IUBMB Life 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a hydrophobic molecule located mainly in membranes it contributes together with other lipids to the physical and structural characteristics such as membrane stability, curvature, fluidity, and the organization into microdomains (lipid rafts). By acting as the main lipid-soluble antioxidant, it protects other lipids such as mono- and poly-unsaturated fatty acids (MUFA and PUFA, respectively) against chemical reactions with reactive oxygen and nitrogen species (ROS and RNS, respectively) and prevents membrane destabilization and cellular dysfunction. Read More

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December 2018

Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions.

Pharmacoepidemiol Drug Saf 2018 Dec 17. Epub 2018 Dec 17.

Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.

Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More

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December 2018

Visceral Obesity Relates to Deep White Matter Hyperintensities via Inflammation.

Ann Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Objective: White matter hyperintensities (WMH) are linked to vascular risk factors and increase the risk of cognitive decline, dementia and stroke. We here aimed to determine if obesity contributes to regional WMH using a whole-brain approach in a well-characterized population-based cohort.

Methods: Waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes and smoking status, blood glucose and inflammatory markers as well as distribution of WMH were assessed in 1825 participants of the LIFE-adult study (age 20-82 years; BMI 18. Read More

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December 2018

The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

FIOCRUZ, Rio de Janeiro. Brazil.

Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More

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December 2018

Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis.

Curr Med Chem 2018 Dec 17. Epub 2018 Dec 17.

Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201. China.

Osteoarthritis (OA) is an age-related degenerative disease, which is characterized by the chronic joint pain, inflammation and the damage of joint cartilage. At present, steroidal drugs and nonsteroidal anti-inflammatory drugs (NSAIDS), selective cyclooxygenase-2 (COX-2) inhibitors, are the first-line drugs for the treatment of OA. However, these drugs could lead to some cardiovascular side effects. Read More

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December 2018

Chicken endothelial cells are highly responsive to viral innate immune stimuli and are susceptible to infections with various avian pathogens.

Avian Pathol 2018 Dec 17:1-41. Epub 2018 Dec 17.

a INRA, Université François Rabelais , UMR1282 Infectiologie et Santé Publique , 37380 Nouzilly , France.

It is well established that the endothelium plays a prominent role in the pathogenesis of various infectious diseases in mammals. However, little is known about the role of endothelial cells (EC) as targets for avian pathogens and their contribution to the pathogenesis of infectious diseases in galliform birds. First, we explored the innate immune response of primary chicken aortic endothelial cells (pchAEC) obtained from 18 day-old embryos to stimulation with pathogen-associated molecular patterns (PAMPs) or recombinant chicken interferons (type I, II and III IFNs). Read More

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December 2018

Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient.

Ann Pharmacother 2018 Dec 17:1060028018817935. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

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December 2018

Analysis of changes in hepatic gene expression and tissue architecture of heart and kidney in association with diet-induced obesity in .

J Biol Regul Homeost Agents 2018 Dec 17;33(1). Epub 2018 Dec 17.

Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore, Pakistan.

Obesity is an epidemic issue associated with low-grade inflammation and in most of the cases with poor iron condition that influences nearly every community. The present research experiment was designed to inspect the consequences of obesity on the micro architecture of heart and kidney tissues as well as on the expression of mRNA of some hepatic genes like Hepcidin, Transferrin and TNF-α in association with their role in iron regulation and proinflammatory responses in the body. Two tentative groups of (each supplied with different proportions of fat in their food) and one control group were analysed. Read More

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December 2018

Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking.

Int J Paediatr Dent 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Background: Antimicrobial peptides play an important role in the local defence of oral cavity. Cigarette smoke has detrimental effects on immune defence mechanisms. The effect of passive smoking on salivary LL-37, as an antimicrobial peptide, in children has not yet been reported. Read More

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December 2018

Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.

J Cell Mol Med 2018 Dec 16. Epub 2018 Dec 16.

Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, China.

Focal inflammation and remyelination failure are major hallmarks of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). In this study, we found that leonurine, a bioactive alkaloid, alleviated EAE disease severity along with reduced central nervous system inflammation and myelin damage. During the pathogenesis of EAE, leonurine dramatically suppressed the recruitment of encephalitogenic T cells into the central nervous system, whereas did not impair periphery immune responses and microglia activation. Read More

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December 2018

Bottoms up: the role of gut microbiota in brain health.

Environ Microbiol 2018 Dec 16. Epub 2018 Dec 16.

Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver.

The gut microbiota affects many aspects of human health, and research, especially over the past decade, is demonstrating that the brain is no exception. This review summarizes existing human observational studies of the microbiota in brain health and neurological conditions at all ages, as well as animal studies that are advancing the field beyond correlation and into causality. Potential mechanisms by which the brain and the gut microbiota are connected are explored, including inflammation, bacterially-produced metabolites and neurotransmitters, and specific roles for individual microbes. Read More

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December 2018

Comparison of 2 differently sized endoscopic biopsy forceps in the evaluation of intestinal disease in cats.

J Vet Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Dipartimento di Medicina Veterinaria, University of Perugia, Perugia, Italy.

Background: In clinical practice, histopathological diagnosis of chronic intestinal disease is challenging because of difficulty in obtaining adequate duodenal samples. At present, no studies have investigated the influence of biopsy forceps size on sample quality in cats.

Objectives: Duodenal biopsy using larger biopsy forceps (2. Read More

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December 2018

Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis.

Clin Exp Immunol 2018 Dec 17. Epub 2018 Dec 17.

Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital Sheba Medical Center.

Background: The antigenic specificity of T cells occurs via generation and rearrangement of different gene segments producing a functional T cell receptor (TCR). High throughput sequencing (HTS) allows in-depth assessment of TCR repertoire patterns. There is limited data whether TCR repertoires are altered in inflammatory bowel disease. Read More

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December 2018

Active neuroborreliosis or inflammation: are the diagnostic guidelines at stake?

Acta Neurol Belg 2018 Dec 17. Epub 2018 Dec 17.

Department of Neuroradiology, AZ St Dimpna, Geel, Belgium.

Neuroborreliosis can induce a variety of neurological syndromes: e.g., cranial neuritis, plexitis, radiculitis, meningitis, cerebellitis, … We report on five cases of patients with a diagnosis of neuroborreliosis based on clinical symptoms, serologic tests and MR imaging results. Read More

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December 2018

Cannabinoid CB Receptor Antagonist Rimonabant Decreases Levels of Markers of Organ Dysfunction and Alters Vascular Reactivity in Aortic Vessels in Late Sepsis in Rats.

Inflammation 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Curitiba, Paraná, Brazil.

Sepsis is a life-threatening condition with high mortality rates that is caused by dysregulation of the host response to infection. We previously showed that treatment with the cannabinoid CB receptor antagonist rimonabant reduced mortality rates in animals with sepsis that was induced by cecal ligation and puncture (CLP). This improvement in the survival rate appeared to be related to an increase in arginine vasopressin (AVP) levels 12 h after CLP. Read More

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December 2018

Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice.

Hepatol Commun 2018 Dec 10;2(12):1533-1549. Epub 2018 Oct 10.

Sorbonne Université, INSERM Centre de Recherche Saint-Antoine (CRSA), and Institute of Cardiometabolism and Nutrition (ICAN) Paris France.

The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF-related cholangiopathy in mice. Cystic fibrosis transmembrane conductance regulator () mice and littermates in a congenic C57BL/6J background were fed a high medium-chain triglyceride (MCT) diet. Read More

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December 2018

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.

Hepatol Commun 2018 Dec 29;2(12):1513-1532. Epub 2018 Oct 29.

Department of Metabolic Health Research Netherlands Organization for Applied Scientific Research Leiden The Netherlands.

Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigated the representation of molecular disease patterns characteristic for human NASH in high-fat diet (HFD)-fed Ldlr-/-.Leiden mice and studied the effects of obeticholic acid (OCA) on these disease profiles. Read More

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December 2018

Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis.

Hepatol Commun 2018 Dec 1;2(12):1493-1512. Epub 2018 Oct 1.

Division of Pediatric Gastroenterology and Hepatology Mayo Clinic Rochester MN.

With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal obesity-inducing diet (OID) on the development and progression of NAFLD in offspring is important but incompletely studied. Hence, we fed breeding pairs of C57BL/6J mice during gestation and lactation (perinatally) either chow or an OID rich in fat, fructose, and cholesterol (FFC). Read More

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December 2018

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice.

Hepatol Commun 2018 Dec 26;2(12):1479-1492. Epub 2018 Sep 26.

Department of Medicine Northwestern University Chicago IL.

Plasminogen activator inhibitor 1 (PAI-1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD). Pharmacologic inhibition of PAI-1 is emerging as a highly promising therapeutic strategy for obesity and its sequelae. Given the well-established profibrotic function of PAI-1, we considered whether PAI-1 may serve as a target for antifibrotic therapy in nonalcoholic steatohepatitis (NASH). Read More

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December 2018

Pituitary metastasis of breast cancer mimicking IgG4-related hypophysitis.

eNeurologicalSci 2019 Mar 22;14:13-15. Epub 2018 Nov 22.

Department of Neurology, Faculty of Medicine, Fukuoka University, Japan.

IgG4-related hypophysitis, which is the pituitary gland inflammation caused by IgG4 positive lymphocytes, can affect cavernous sinus and orbital apex leading to developing cranial nerve related symptoms such as orbital apex syndrome (OAS). Here we report a case of hypopituitarism associated with OAS caused by pituitary metastasis of the breast cancer with elevated serum IgG4 level, who initially resembled to IgG4-related hypophysitis. Although this case had some features in common with igG4-related hypophysitis. Read More

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