652,753 results match your criteria Inflammation & Allergy - Drug Targets[Journal]


Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
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[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://dx.doi.org/10.1055/a-0854-3421DOI Listing

Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Nephron 2019 Apr 18:1-5. Epub 2019 Apr 18.

Department of Anaesthesiology, Critical Care Medicine and Burn unit, AP-HP, Saint Louis University Hospitals, Paris, France,

The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Read More

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http://dx.doi.org/10.1159/000499940DOI Listing

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
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Obesity Induces Ovarian Inflammation and Reduces Oocyte Quality.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Wood, Animal Science, University of Nebraska, Lincoln, 68583-0908, United States.

In the US, 36.5 percent of women between the ages of 20-39 are obese. This obesity results in not only metabolic disorders including type II diabetes and cardiovascular disease, but also impaired female fertility. Read More

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http://dx.doi.org/10.1530/REP-18-0583DOI Listing

Dietary inflammatory index is positively associated with serum high-sensitivity C-reactive protein in a Korean adult population.

Nutrition 2018 Nov 23;63-64:155-161. Epub 2018 Nov 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA; Connecting Health Innovations LLC, Columbia, South Carolina, USA.

Objective: To our knowledge, only a few studies have explored the relationship between the inflammatory potential of diet and serum inflammatory markers in Korean adults. The likely novel aim of this study was to examine the association between the dietary inflammatory index (DII) and serum high-sensitivity C-reactive protein (hs-CRP) in a Korean adult population.

Methods: A cross-sectional study was conducted using the data set from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.016DOI Listing
November 2018

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.

Environ Int 2019 Apr 15;127:720-729. Epub 2019 Apr 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States of America. Electronic address:

Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd worsened inflammation in response to sub-lethal H1N1 infection. Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.054DOI Listing

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3 inflammasome.

Biomed Pharmacother 2019 Apr 15;115:108868. Epub 2019 Apr 15.

Department of Geriatrics, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

The characteristic feature of obesity and insulin resistance is chronic low-grade inflammation. Nod-Like Receptor Pyrin 3 (NLRP3) inflammasome plays a central role in obesity-induced insulin resistance. However, how does Carbenoxolone (CBX) play its role in ameliorating insulin resistance in peripheral tissues of obese mice induced by high-fat diet (HFD) remains unknown. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108868DOI Listing

Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations.

J Affect Disord 2019 Apr 9;252:350-357. Epub 2019 Apr 9.

Research and Knowledge Center, The Danish Veteran Center, Garnisonen 1, 4100 Ringsted, Denmark.

Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder that occurs with relatively high frequency after deployment to warzones (∼10%). While twin studies have estimated the heritability to be up to 40%, thus indicating a considerable genetic component in the etiology, the biological mechanisms underlying risk and development of PTSD remain unknown.

Methods: Here, we conduct a genome-wide association study (GWAS; N = 2,481) to identify genome regions that associate with PTSD in a highly homogenous, trauma-exposed sample of Danish soldiers deployed to war and conflict zones. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.070DOI Listing

Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis.

Arch Oral Biol 2019 Apr 9;102:113-121. Epub 2019 Apr 9.

Department of Periodontology, School of Dentistry, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: The aim of this systematic review was to evaluate the existing evidence on the association between Thalassemia major (TM) and periodontal condition.

Materials & Methods: MEDLINE via OVID, EMBASE, and The Cochrane Database (including the Central Register of Controlled Trials (CENTER)), were searched up to September 2018 to identify observational studies eligible for systematic review and meta-analyses. Newcastle-Ottawa Scale (NOS) was used for quality assessment. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.004DOI Listing

Inhalable co-amorphous budesonide-arginine dry powders prepared by spray drying.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road 103, 110016, Shenyang, China. Electronic address:

Spray drying is a well-established technology to produce inhalable dry powders. However, the amorphous nature of the particles typically obtained from the process can lead to physically and chemically unstable products. The purpose of this study was to investigate whether spray-drying could be used as a manufacturing method to produce co-amorphous drug amino acid powders with high physical stability and inhalable particulate properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193029
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.036DOI Listing
April 2019
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Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Fractional CO laser treatment has been used in some clinical trials to promote topical drug delivery. Currently, there is no standard for laser settings to achieve a feasible therapy. The cutaneous recovery following laser treatment and its influence on drug absorption have not been well explored. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.043DOI Listing

Adverse and hormetic effects in rats exposed for 12 months to low dose mixture of 13 chemicals: RLRS part III.

Toxicol Lett 2019 Apr 15. Epub 2019 Apr 15.

Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, Moscow 119991, Russian Federation. Electronic address:

The aim of the current study was to evaluate the effects of a mixture of thirteen common chemicals on rats, after a one-year exposure to doses around the acceptable daily intake (ADIs), using blood and urinary tests. The influence of low doses of the mixture on weight gain, water consumption, feed consumption and feed efficiency, biochemistry parameters, haematological parameters, blood lymphocytes subsets, serum inflammation profile and urine parameters was evaluated. Our mixture caused a moderate monotonic increase of the males' appetite and a non-monotonic increase of anabolism and a monotonic increase of appetite for the females. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.04.005DOI Listing

Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia plays a critical role in exacerbating inflammation, white matter injury, and cognitive impairment during chronic cerebral hypoperfusion; however, the physiological or pathophysiological role of TRPM2 during age-associated inflammatory responses remains unclear. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.012DOI Listing

Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.

Brain Behav Immun 2019 Apr 15. Epub 2019 Apr 15.

Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, California 90095, United states; Department of Psychology, University of California Los Angeles, Los Angeles, California 90095, United states.

This study provides a comprehensive review of the published research on the association between early life adversity and markers of inflammation in children and adolescents. We conducted a systematic review of the published literature on the association between early life adversity and markers of inflammation in pediatric populations. To date, 27 studies have been published in this area representing a wide range of global populations and diverse methods of which nearly half were prospective, longitudinal studies. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.04.028DOI Listing

Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects.

J Ethnopharmacol 2019 Apr 15:111890. Epub 2019 Apr 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: Capparis erythrocarpos is a medicinal plant used widely in many parts of Africa for the management of pain and inflammatory conditions such as rheumatoid arthritis. Its wide range of use, popularity and high value, make C. erythrocarpos containing products a target for economically driven adulteration. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111890DOI Listing

Lipoxygenase drives Lipidomic and metabolic reprogramming in ischemic heart failure.

Metabolism 2019 Apr 15. Epub 2019 Apr 15.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, AL, United States.

Background: After myocardial infarction (MI), delayed progression or reversal of cardiac remodeling is a prime target to limit advanced chronic heart failure (HF). However, the temporal kinetics of lipidomic and systemic metabolic signaling is unclear in HF. There is no consensus on metabolic and lipidomic signatures that influence structure, function, and survival in HF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193007
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http://dx.doi.org/10.1016/j.metabol.2019.04.011DOI Listing
April 2019
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High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via IL8 and Alterations to the Gut Microbiome.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine, Technical University of Munich, Germany. Electronic address:

Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environmental or dietary factors associated with obesity contribute to progression of BE to EAC in mice. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.04.013DOI Listing
April 2019
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IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
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Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity.

Authors:
Brian C Weiner

Clin Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Clinical Associate Professor, Medicine, Gastroenterology, Hepatology, Nutrition. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.023DOI Listing

Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, shaanxi, 710032, China. Electronic address:

Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8 cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern (DAMP) molecule with strong proinflammatory effects in inflammatory reactions. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1148DOI Listing

Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.013DOI Listing

AC-SDKP treatment protects heart against excessive myocardial injury and heart failure in mice.

Can J Physiol Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Henry Ford Hospital, 24016, Hypertension & Vascular Research Division/Department of Internal Medicine, Detroit, Michigan, United States.

Myocardial infarction (MI) in mice results in cardiac rupture at 4-7 days post-MI, whereas cardiac fibrosis and dysfunction occur later. Ac-SDKP has anti-inflammatory, anti-fibrotic, and pro-angiogenic properties. We hypothesized that Ac-SDKP reduces cardiac rupture and adverse cardiac remodeling, and improves function by promoting angiogenesis and inhibiting detrimental reactive fibrosis and inflammation after MI. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0047DOI Listing

HIV disease, metabolic dysfunction and atherosclerosis: A three year prospective study.

PLoS One 2019 18;14(4):e0215620. Epub 2019 Apr 18.

Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

HIV infection is known to be associated with cardiometabolic abnormalities; here we investigated the progression and causes of these abnormalities. Three groups of participants were recruited: HIV-negative subjects and two groups of treatment-naïve HIV-positive subjects, one group initiating antiretroviral treatment, the other remaining untreated. Intima-media thickness (cIMT) increased in HIV-positive untreated group compared to HIV-negative group, but treatment mitigated the difference. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215620PLOS
April 2019
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TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

PLoS Pathog 2019 Apr 18;15(4):e1007657. Epub 2019 Apr 18.

Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, United Kingdom.

Helminths are highly prevalent metazoan parasites that infect over a billion of the world's population. Hosts have evolved numerous mechanisms to drive the expulsion of these parasites via Th2-driven immunity, but these responses must be tightly controlled to prevent equally devastating immunopathology. However, mechanisms that regulate this balance are still unclear. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007657DOI Listing

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS One 2019 18;14(4):e0215746. Epub 2019 Apr 18.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcription factor Krüppel-like factor (KLF4) is implicated in a large number of cellular processes, such as proliferation, differentiation, and inflammation in esophageal epithelia. In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215746PLOS

RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis.

PLoS One 2019 18;14(4):e0215132. Epub 2019 Apr 18.

Mass General Hospital for Children and Division of Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, Massachusetts, United States of America.

Background & Aims: The early steps in the pathophysiology of celiac disease (CD) leading to loss of tolerance to gluten are poorly described. Our aim was to use RNA sequencing of duodenal biopsies in patients with active CD, CD in remission, and non-CD controls to gain insight into CD pathophysiology, identify additional genetic signatures linked to CD, and possibly uncover targets for future therapeutic agents.

Methods: We performed whole transcriptome shotgun sequencing of intestinal biopsies in subjects with active and remission CD and non-CD controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215132PLOS

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.

PLoS One 2019 18;14(4):e0211559. Epub 2019 Apr 18.

Kidney Disease Section, NIDDK, NIH, Bethesda, Maryland, United States of America.

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211559PLOS

Sumatriptan increase skin flap survival through activation of 5HT 1b/1d receptors in rats: the mediating role of nitric oxide pathway.

Plast Reconstr Surg 2019 Apr 11. Epub 2019 Apr 11.

School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Random pattern skin flaps are applicable to reconstruct any defects in plastic surgery. However, they are limited to apply due to necrosis. Sumatriptan, a selective 5HT 1b/1d agonist, routinely use to subset acute migraine attack. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005740DOI Listing
April 2019
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Cholecystokinin Modulates the Mucosal Inflammatory Response and Prevents the Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction.

Shock 2019 Apr 14. Epub 2019 Apr 14.

Department of Physiology, Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, São Paulo, Brazil.

The intestinal mucosa plays a critical role in the organism, acting as an interface between the lamina propria and the harmful antigens in the lumen. Sepsis is associated with primary injury to the intestinal mucosa, which in turn induces bacterial translocation and hyperpermeability. Cholecystokinin (CCK) is a peptide synthesized by several cell types, whose immunomodulatory activity has been reported in experimental models of inflammation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001355DOI Listing

Surgical Treatment Strategy for Severe Rhinophyma With Bilateral Pedicled Nasolabial Flaps.

J Craniofac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Plastic and Reconstructive Surgery, The First Affiliated Hospital of China Medical University, People's Republic of China.

Background: Rhinophyma is a rare disease characterized by chronic inflammation and hypertrophy of sebaceous glands, blood vessels, and fibrous tissue, associated with end-stage severe acne rosacea. There are multiple approaches to treatment and repair, including dermal shaving, secondary intention healing, free skin graft, and skin flaps. However, these methods have various disadvantages, such as prolonged healing, obvious scarring, and skin texture mismatch. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005524DOI Listing

Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

J Interferon Cytokine Res 2019 Apr 17. Epub 2019 Apr 17.

4 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

A meeting entitled, "Interferon Lambda: Disease Impact and Translational Potential," was held on the campus of the National Institutes of Health in Bethesda, Maryland, on October 25-26, 2018. To our knowledge, this was the first meeting that focused exclusively on interferon lambda (IFN-λ). The meeting's purpose was to enhance interdisciplinary communication and promote new collaborations. Read More

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http://dx.doi.org/10.1089/jir.2019.0018DOI Listing

MicroRNA-155: A Master Regulator of Inflammation.

J Interferon Cytokine Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

MicroRNAs (miRNAs) are naturally occurring, highly conserved families of transcripts (∼22 nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily regulate gene expression by promoting messenger RNA (mRNA) degradation or repressing mRNA translation. miRNAs have been shown to be important regulators of a variety of cellular processes involving development, differentiation, and signaling. Read More

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http://dx.doi.org/10.1089/jir.2018.0155DOI Listing

Influence of Baseline Anemia on Dual Antiplatelet Therapy Cessation and Risk of Adverse Events After Percutaneous Coronary Intervention.

Circ Cardiovasc Interv 2019 Apr;12(4):e007133

Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, NY (M.F., U.B., S. Sartori, J.C., B.E.C., G.D., B.V., S. Sorrentino, A.K., S.F., R.M.).

Background: Anemia is a well-recognized risk factor for both bleeding and ischemic events after percutaneous coronary intervention (PCI). We sought to determine the impact of baseline anemia on dual antiplatelet therapy (DAPT) cessation patterns ≤2 years after PCI and the subsequent risk of clinical adverse events.

Methods And Results: PARIS (Patterns of Non-Adherence to Dual Anti-Platelet Regimen in Stented Patients) was a prospective multicenter observational registry of PCI-treated patients (n=5018). Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007133DOI Listing

Heat shock proteins and psoriasis.

Eur J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaArticle accepted on October 23, 2018.

Psoriasis is a chronic disfiguring skin condition which may be induced or exacerbated by stress. Heat shock proteins (HSPs), as molecular chaperones, play a central role in protein folding and cellular protein homeostasis. The many different functions of HSPs in the cell depend on the specific HSP involved. Read More

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http://dx.doi.org/10.1684/ejd.2019.3526DOI Listing

Incretins-adipocytokines interactions in type 2 diabetic subjects with or without non-alcoholic fatty liver disease: interest of GLP-1 (glucagon-like peptide-1) as a modulating biomarker.

Ann Biol Clin (Paris) 2019 Apr 17. Epub 2019 Apr 17.

Université des sciences et de la technologie Houari Boumediene, Faculté des sciences biologiques, Laboratoire de biologie et physiologie des organismes, Équipe de bioénergétique et métabolisme intermédiaire, Alger, Algérie.

Type 2 diabetes (T2DM) associated with non-alcoholic fatty liver disease (NAFLD) increases cardiovascular risk. Complex and subtle connections are established between hepatic dysfunction and adipose tissue hyperactivity. This relationship is mediated by insulin resistance, dyslipidemia and inflammation. Read More

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http://dx.doi.org/10.1684/abc.2019.1436DOI Listing

Analog Derivatization of Cannabidiol for Improved Ocular Permeation.

J Ocul Pharmacol Ther 2019 Apr 18. Epub 2019 Apr 18.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi.

Cannabidiol (CBD), active component of plant , has anti-inflammatory properties that could potentially help treat diabetic retinopathy-induced pain and inflammation. However, CBD is a lipophilic molecule making its topical delivery to back of the eye challenging. This study aims at improving ocular penetration of CBD by means of analog derivatization. Read More

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http://dx.doi.org/10.1089/jop.2018.0141DOI Listing

Perceived social support and chronic inflammation: The moderating role of self-esteem.

Health Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology.

Objective: Social support is one of the strongest psychosocial predictors of physical health. However, is this the case for everyone? On the basis of recent research suggesting that self-esteem can moderate the psychological effects of social support, the present research investigated whether self-esteem would moderate the health benefits of social support.

Method: A national sample of middle-aged adults (N = 949) completed self-report questionnaires on perceived social support, self-esteem, sociodemographic information, and health related behaviors. Read More

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http://dx.doi.org/10.1037/hea0000746DOI Listing

Frontline Science: TLR3 activation inhibits food allergy in mice by inducing IFN-γ Foxp3 regulatory T cells.

J Leukoc Biol 2019 Apr 18. Epub 2019 Apr 18.

Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.

The pathologic feature of food allergy (FA) is the aberrant Th2-biased immune response in the intestine. Regulatory T cells (Tregs) play an important role in the suppression of aberrant immune response. The activities of the TLRs regulate multiple cell functions. Read More

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http://dx.doi.org/10.1002/JLB.3HI0918-348RRDOI Listing

The Influence of Proinflammatory Cytokines on Voriconazole Trough Concentration in Patients With Different Forms of Hematologic Disorders.

J Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Even though multiple factors are involved in the high fluctuation of voriconazole (VCZ) plasma concentration, little is known regarding the influence of proinflammatory cytokines on VCZ concentration. The aim of this study was to investigate the influence of proinflammatory cytokines, namely, interleukin (IL)-1β, IL-6, IL-18, interferon-γ, tumor necrosis factor-α, and transforming growth factor (TGF)-β1 on VCZ trough concentration (VCZ-C ) in Chinese patients with different forms of hematologic disorders. A total of 250 plasma samples from 113 patients were analyzed for VCZ-C and proinflammatory cytokines using a validated liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay methods, respectively. Read More

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http://dx.doi.org/10.1002/jcph.1422DOI Listing

Serum miR-21 expression correlates with radiographic progression but also low bone mineral density in patients with ankylosing spondylitis: a cross-sectional study.

Innate Immun 2019 Apr 18:1753425919842932. Epub 2019 Apr 18.

2 Department of Rehabilitation Medicine, Southern Medical University, Guang Zhou, China.

Increased expressions of miR-21 have been detected in ankylosing spondylitis (AS) patients. The current study was performed to examine the serum miR-21 expression with radiographic severity in AS patients, which was determined based on the modified New York (NY) criteria for sacroiliac joints assessment and modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) system for spine involvement. Bone mineral density at lumbar 1-4 and femoral neck were examined by dual-energy absorptiometry (DXA). Read More

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http://dx.doi.org/10.1177/1753425919842932DOI Listing

A review of the fate of inhaled α-quartz in the lungs of rats.

Authors:
Hajime Kawasaki

Inhal Toxicol 2019 Apr 18:1-10. Epub 2019 Apr 18.

a Chemical Health Science Japan Co. Ltd , Osaka , Japan.

The distribution of dust particles within the lungs and their excretion are highly associated with their pulmonary toxicity. Literature was reviewed to discern pulmonary translocation pathways for inhaled α-quartz compared to those for inhaled TiO. Accordingly, it was hypothesized α-quartz particles in the alveoli were phagocytized by alveolar macrophages but silica-containing macrophages remained in the alveoli for longer time in contrast to the rapid elimination from the alveoli seen for TiO-containing macrophages. Read More

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http://dx.doi.org/10.1080/08958378.2019.1597218DOI Listing

Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease

Turk J Med Sci 2019 Apr 18;49(2):478-482. Epub 2019 Apr 18.

Background/aim: Abnormal immune response occurs in individuals who have alleles associated with innate and adaptive immune mechanisms that predispose to inflammatory bowel disease (IBD). Interleukin-1 receptor-associated kinase 4 (IRAK-4) involved in the pathway produces cytokines that initiate and maintain inflammation through Toll-like receptors and interleukin-1 receptors on the membranes of innate immune cells are stimulated with antigens. It was aimed to investigate whether IRAK-4 rs3794262 and rs4251481 polymorphisms predispose to IBD and the possible effects of these polymorphisms by examining these gene polymorphisms with the clinic and prognostic parameters of IBD. Read More

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http://dx.doi.org/10.3906/sag-1807-279DOI Listing

Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

It has been reported that asprosin is a novel adipokine which is augmented in mice and humans with type 2 diabetes (T2DM). Asprosin stimulates hepatic gluconeogenesis under fasting conditions. However, the roles of asprosin in inflammation, endoplasmic reticulum (ER) stress, and insulin resistance in skeletal muscle has not been studied. Read More

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http://dx.doi.org/10.1002/jcp.28694DOI Listing

Autoinflammatory Disorders: A Review and Update on Pathogenesis and Treatment.

Am J Clin Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The autoinflammatory diseases comprise a broad spectrum of disorders characterized by unchecked activation of the innate immune system. Whereas aberrations in adaptive immunity have long been identified in 'autoimmune' disorders, the concept of 'autoinflammation' emerged relatively recently, first describing a group of clinical disorders characterized by spontaneous episodes of systemic inflammation without manifestations typical of autoimmune disorders. Improved knowledge of innate immune mechanisms, coupled with remarkable progress in genomics and an expanding number of clinical cases, has since led to an increasing number of disorders classified as autoinflammatory or containing an autoinflammatory component. Read More

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http://dx.doi.org/10.1007/s40257-019-00440-yDOI Listing

Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.

Inflammation 2019 Apr 17. Epub 2019 Apr 17.

Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.

Sudachitin, a polymethoxylated flavonoid found in the skin of Citrus sudachi, is a biologically active substance. The aim of this study was to examine whether sudachitin could be used to inhibit the expression of matrix metalloproteinase (MMP)-1 and MMP-3, which are involved in the destruction of periodontal tissues in periodontal lesions, in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Sudachitin suppressed TNF-α-induced MMP-1 and MMP-3 production in HPDLC. Read More

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http://dx.doi.org/10.1007/s10753-019-01007-zDOI Listing

Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs ().

Heliyon 2019 Apr 5;5(4):e01432. Epub 2019 Apr 5.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Colimes y Granados 170513, Ecuador.

Bone alterations due to metabolic bone disease in captive animal populations can have a negative impact on repopulation and research initiatives. This investigation has the purpose of describing the principal radiographic and anatomopathological findings present in nine gliding leaf frogs () kept in captivity with alterations in their spines and long bones. The observed histopathological findings were in the canalis vertebralis, paraspinal muscle and long bones, and included deformed bones with alteration of the adjacent tissues, alterations in the ossification process, bone degeneration and resorption, decreased number of osteocytes and deposition of osteoid and fibrous material in the compact bone tissue. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451164PMC

LncRNA: An All-rounder in Rheumatoid Arthritis.

J Transl Int Med 2019 Mar 29;7(1):3-9. Epub 2019 Mar 29.

Division of Rheumatology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, Hangzhou, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. Read More

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http://dx.doi.org/10.2478/jtim-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463828PMC

Avenanthramides attenuate inflammation and atrophy in muscle cells.

J Sport Health Sci 2019 Mar 24;8(2):189-195. Epub 2018 Aug 24.

Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.

Background: Chronic inflammation is an important etiologic mechanism for muscle atrophy. Oat-derived phytochemical avenanthramides (AVAs) have been shown to suppress inflammatory responses in human clinical studies and in several cell lines , but their role in skeletal muscle is unclear. The aim of this study was to investigate whether AVA treatment can prevent tumor necrosis factor (TNF)-α-induced muscle fiber atrophy in C2C12 cells. Read More

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http://dx.doi.org/10.1016/j.jshs.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451048PMC

Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis.

Clin Transl Immunology 2019 6;8(4):e1045. Epub 2019 Apr 6.

Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia.

Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response.

Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Read More

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http://dx.doi.org/10.1002/cti2.1045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451750PMC
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