645,139 results match your criteria Inflammation & Allergy - Drug Targets[Journal]


Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability of airway inflammation.

Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.011DOI Listing
February 2019

Increased CD16 expression on NK cells is indicative of antibody-dependent cell-mediated cytotoxicity in chronic-active antibody-mediated rejection.

Transpl Immunol 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands.

Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. The antibodies directed against donor-derived antigens, e.g. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.005DOI Listing
February 2019

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge (Danshen), displays many bioactivities. However, the activity and underlying mechanism of DHT in anti-inflammation have not yet been elucidated. In this study, we investigated the anti-inflammatory activity and molecular mechanism of action of DHT both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.017DOI Listing
February 2019

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Shipping warehouse No. 5, Beijing, 100700, China. Electronic address:

The role of gut microbiota in the management of diabetes has been shown. Several current trials are investigating the effect of probiotics and prebiotics, which are widely used to modulate intestinal microbiota, on inflammatory factors and biomarkers of oxidative stress in diabetic patients; however, their findings are controversial. The aim of the current meta-analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high-sensitivity C-reactive protein (hs-CRP) and biomarkers of oxidative stress in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.016DOI Listing
February 2019

Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Xiyuan Caochang 1, Beijing 100091, China. Electronic address:

The gut microbiota harvests nutrients from the host while making possible the digestion of complex nutrients and regulating and balancing the immune and metabolic functions. The microbiota itself, and the dysbiosis of the gut flora, are correlated to the onset and progress of diabetes, obesity, and atherosclerosis. Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.018DOI Listing
February 2019

Diverse lignans with anti-inflammatory activity from Urceola rosea.

Fitoterapia 2019 Feb 19. Epub 2019 Feb 19.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Seventeen structurally diverse lignans, comprising six new compounds, ecdysanols A (1), B (11), C - E (13-15), and F (17), were isolated from the caulis of Urceola rosea. The structures and absolute configurations of these new compounds were elucidated by means of extensive analysis of mass and NMR data, as well as chiroptical properties. A bioassay in vitro showed that all lignans possessed anti-inflammatory effects by inhibiting the production of TNF-α, NO and/or IL-6 in LPS-stimulated RAW264. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.011DOI Listing
February 2019
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Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Sciences (Biochemistry Program), Faculty of Science, Kuwait University, P.O. Box 5969, 13060, Kuwait.

The human Receptor for Advanced Glycation End Products (hRAGE) is a pattern recognition receptor implicated in inflammation and adhesion. It is involved in both innate and adaptive immunity. Its aberrant signaling is tied to the pathogenesis of diabetic complications, neurodegenerative disorders, and chronic inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.108DOI Listing
February 2019

Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro.

J Ethnopharmacol 2019 Feb 19. Epub 2019 Feb 19.

Centre for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Straße 115 B, 79106 Freiburg, Germany. Electronic address:

Ethnopharmacological Relevance: The improvement of wound healing has always been an important issue for both ethnopharmacological and modern medical research. In this study, we used state-of-the-art methods to investigate extracts of plants used traditionally in Nepal for more than 1,000 years to treat inflammatory skin injuries.

Aim Of The Study: We focused on the potential of the plant extracts to ameliorate wound healing and to influence immune modulatory properties. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.034DOI Listing
February 2019

Moderate running exercise prevents excessive immune system activation.

Physiol Behav 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address:

Benefits of exercise have been documented for many diseases with a chronic progression, including obesity, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, certain types of cancers, and overall mortality. Low-grade systemic inflammation is a key component of these pathologies and it has been demonstrated that can be prevented by performing regularly physical exercise. The aim of this study was to examine the effect of lipopolysaccharide (LPS)-induced inflammation on glucose and insulin tolerance, exercise performance, production of urinary neopterin and striatal neurotransmitters levels in adult male C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.023DOI Listing
February 2019

Propagermanium, a CCR2 inhibitor, attenuates cerebral ischemia/reperfusion injury through inhibiting inflammatory response induced by microglia.

Neurochem Int 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China. Electronic address:

CCR2 could recruit immune cells migrating into brain after ischemic stroke. It is unclear whether and why Propagermanium (PG, a CCR2 inhibitor) is able to protect against ischemic injury. Middle cerebral artery occlusion (MCAO) and reperfusion injury in C57BL/6 J male mice were performed in vivo to mimic ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.02.010DOI Listing
February 2019

Cytoplasmic OH scavenger TA293 attenuates cellular senescence and fibrosis by activating macrophages through oxidized phospholipids/TLR4.

Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.

Aims: Elucidation of the biological roles of the mitochondrial and cytoplasmic hydroxyl radical (cyto OH) is hampered by the absence of site-specific OH scavengers. Earlier findings using cyto OH scavenger, TA293, indicated that cyto OH causes cellular senescence, and senescence-associated secretory phenotype (SASP) factors secreted from cells cause macrophage infiltration, inflammation, and apoptosis. However, we found that macrophage infiltration occurs before senescent cells appear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.038DOI Listing
February 2019

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Toxicol Appl Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ, USA. Electronic address:

Introduction: Nonalcoholic steatohepatitis (NASH) afflicts 20-36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages express folate receptor beta (FR-β) which may be an indicator of progression from steatosis to NASH. Read More

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http://dx.doi.org/10.1016/j.taap.2019.02.009DOI Listing
February 2019

Maxillofacial Implications of Scleroderma and Systemic Sclerosis: A Case Report and Literature Review.

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Assistant Professor and Associate Program Director, Department of Oral and Maxillofacial Surgery, University of Rochester Medical Center, Eastman Institute for Oral Health, Rochester, NY.

Scleroderma and more generally systemic sclerosis comprise a group of autoimmune diseases characterized by increased collagen synthesis and deposition within connective tissue. The Scleroderma Foundation estimates that as many as 300,000 persons in the United States have scleroderma. Although the etiology of the disease is unknown, it is thought to be related to chronic inflammation secondary to autoimmune tissue damage. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.027DOI Listing
January 2019

Renal iron accumulation and oxidative injury with aging: effects of treatment with an iron chelator.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Health and Human Physiology, The University of Iowa.

Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 mo) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4. Read More

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http://dx.doi.org/10.1093/gerona/glz055DOI Listing
February 2019

Cigarette smoke extracts and cadmium induce COX-2 expression through γ-secretase-mediated p38 MAPK activation in C6 astroglia cells.

PLoS One 2019 22;14(2):e0212749. Epub 2019 Feb 22.

Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Republic of Korea.

Exposure to cigarette smoke has been implicated in the progression of cerebrovascular and neurological disorders like stroke through inflammation and blood-brain barrier disruption. In this study, we investigated the signaling cascade activated by cigarette smoke extracts (CSE) and cadmium (Cd) resulting in the COX-2 induction in C6 rat astroglia cells. CSE or Cd induced Notch1 cleavage and activated p38 MAPK and CREB signaling pathways in C6 astroglia cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212749PLOS
February 2019

The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells.

PLoS One 2019 22;14(2):e0212850. Epub 2019 Feb 22.

Department of Biochemistry & Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.

Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that are associated with a predisposition for developing IBD. For the majority, the causal variant and target genes affected are unknown. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212850PLOS
February 2019

Omentin protects H9c2 cells against docetaxel cardiotoxicity.

PLoS One 2019 22;14(2):e0212782. Epub 2019 Feb 22.

Cardiology Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela and Health Research Institute, University Clinical Hospital of Santiago de Compostela-Santiago de Compostela, Spain.

Background: Association between obesity and cardiovascular diseases is well known, however increased susceptibility of obese patients to develop several cancer types is not so commonly known. Current data suggest that poorer overall survival in cancer patients might be associated to non-cancer-related causes such as higher risk of cardiotoxicity in obese patients treated with chemotherapeutic agents. Omentin, a novel adipokine decreased in obesity, is actually in the spotlight due to its favourable effects on inflammation, glucose homeostasis and cardiovascular diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212782PLOS
February 2019

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity.

PLoS One 2019 22;14(2):e0212648. Epub 2019 Feb 22.

State Key Laboratory of Cultivation Base for Photoelectric Technology and Functional Materials, Institute of Photonics and Photon-Technology, Northwest University, Xi'an, China.

Senile plaques are well-known hallmarks of Alzheimer's Diseases (AD). However, drugs targeting tangles of the protein tau and plaques of β-amyloid have no significant effect on disease progression, and the studies on the underlying mechanism of AD remain in high demand. Growing evidence supports the protective role of senile plaques in local inflammation driven by S100A9. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212648PLOS
February 2019

The association of HLA-G polymorphisms and the synergistic effect of sMICA and sHLA-G with chronic kidney disease and allograft acceptance.

PLoS One 2019 22;14(2):e0212750. Epub 2019 Feb 22.

Laboratório de Imunogenética e Histocompatibilidade, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

The HLA-G and MICA genes are stimulated under inflammatory conditions and code for soluble (sMICA and sHLA-G) or membrane-bound molecules that exhibit immunomodulatory properties. It is still unclear whether they would have a synergistic or antagonistic effect on the immunomodulation of the inflammatory response, such as in chronic kidney disease (CKD), contributing to a better prognosis after the kidney transplantation. In this study, we went from genetic to plasma analysis, first evaluating the polymorphism of MICA, NKG2D and HLA-G in a cohort from Southern Brazil, subdivided in a control group of individuals (n = 75), patients with CKD (n = 94), and kidney-transplant (KT) patients (n = 64). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212750PLOS
February 2019

Pancreatic autoantibodies and CD14+CD16+ monocytes subset are associated with the impairment of ß-cell function after simultaneous pancreas-kidney transplantation.

PLoS One 2019 22;14(2):e0212547. Epub 2019 Feb 22.

Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain.

Pancreatic autoantibodies (AAb) has been associated with a worse pancreas graft survival after simultaneous pancreas-kidney transplantation (SPK). However, due to the variable time for AAb to become positive and the lack of early biomarkers suggesting such autoimmune activation, the mechanisms leading ß-cell destruction remain uncertain. The present study aimed to evaluate the association between post-transplant AAb and the functional impairment of the pancreatic ß-cell and also the association of such AAb with inflammation after SPK. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212547PLOS
February 2019

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

PLoS One 2019 22;14(2):e0212236. Epub 2019 Feb 22.

Department of Biology, Missouri State University, Springfield, Missouri, United States of America.

Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212236PLOS
February 2019

Culture-Proven Candida Albicans Endogenous Endophthalmitis in a Patient with Onychomycosis.

Ocul Immunol Inflamm 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Department of Ophthalmology , Ankara University Faculty of Medicine , Ankara , Turkey.

Purpose: To report a case of Candida albicans endogenous endophthalmitis in an immunocompetent patient with onychomycosis.

Methods: Retrospective case report.

Results: A 40-year-old man with onychomycosis presented with C. Read More

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http://dx.doi.org/10.1080/09273948.2019.1568503DOI Listing
February 2019

The pharmacological management of patients with comorbid psoriasis and obesity.

Expert Opin Pharmacother 2019 Feb 22:1-10. Epub 2019 Feb 22.

b Section of Dermatology and Venereology, Department of Medicine , University of Verona , Verona , Italy.

Introduction: Psoriasis is a chronic inflammatory skin disease that is increasingly being recognized as a complex disorder affecting multiple systems. Systemic inflammation is considered the pathogenic link between psoriasis and its comorbid conditions that include arthritis, metabolic disorders, depression, and cardiovascular diseases. The presence of comorbid conditions modifies both its clinical management and the therapeutic approach in psoriatic patients. Read More

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http://dx.doi.org/10.1080/14656566.2019.1583207DOI Listing
February 2019

Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

FASEB J 2019 Feb 22:fj201801682R. Epub 2019 Feb 22.

Centre for Biological Timing, Faculty of Biology, Health and Medicine, University of Manchester, Manchester, United Kingdom.

Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 ( Bmal1) in AECs. Pulmonary neutrophil infiltration, biomechanical function, and responses to influenza infection were all disrupted. Read More

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http://dx.doi.org/10.1096/fj.201801682RDOI Listing
February 2019

Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions.

Aging Cell 2019 Feb 22:e12850. Epub 2019 Feb 22.

U995 - Lille Inflammation Research International Center, INSERM, CHU Lille, University of Lille, Lille, France.

Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). The role of dietary AGEs in aging remains ill-defined, but the predominantly renal accumulation of dietary carboxymethyllysine (CML) suggests the kidneys may be particularly affected. We studied the impact of RAGE invalidation and a CML-enriched diet on renal aging. Read More

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http://dx.doi.org/10.1111/acel.12850DOI Listing
February 2019

NK cell immune responses differ after prime and boost vaccination.

J Leukoc Biol 2019 Feb 22. Epub 2019 Feb 22.

CEA, Université Paris Sud 11, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT, IBFJ, CEA, Fontenay-aux-Roses, France.

A better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified vaccinia virus Ankara using cynomolgus macaques as a model. Mass cytometry was used to deeply characterize blood NK cells. Read More

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http://doi.wiley.com/10.1002/JLB.4A1018-391RR
Publisher Site
http://dx.doi.org/10.1002/JLB.4A1018-391RRDOI Listing
February 2019
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Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

Centre for Nutrition and Gastrointestinal Disease, Adelaide Medical School, University of Adelaide & South Australian Health and Medical Research Institute, Adelaide, Australia.

Background: Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis.

Methods: Mice were administered trinitrobenzene sulphonic acid (TNBS) via enema, and inflammation was assessed 2 days (d2) or 28 days (d28) later. Colitis was reactivated in some mice by re-treating at 28 days with TNBS and assessing 2 days later (d30). Read More

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http://dx.doi.org/10.1093/ibd/izz011DOI Listing
February 2019

Rising exposure to food-grade carrageenan and concerning evidence mandate revisiting its safety and regulation.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

Laboratory of Chemistry of Foods and Bioactives, Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, Israel.

This commentary re-emphasizes the aim of our recent review (David et al., 2018) and addresses some of the points raised in the adjacent commentary by M. Weiner and J. Read More

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http://dx.doi.org/10.1039/c9fo00018fDOI Listing
February 2019

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.

Int J Stroke 2019 Feb 22:1747493019834191. Epub 2019 Feb 22.

1 Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Background: Stroke is a major cause of disability and mortality. Poorer outcome after stroke is associated with concomitant inflammatory and infectious disease. Periodontitis is a chronic inflammatory disease of the dental supporting structures and is a prominent risk factor for many systemic disorders, including cardiovascular disease and stroke. Read More

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http://dx.doi.org/10.1177/1747493019834191DOI Listing
February 2019

A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa.

J Am Coll Nutr 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Gastrointestinal Unit, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana , University of Salerno , Baronissi , SA , Italy.

Objective: Celiac disease is an immune-mediated disease of the intestine triggered by gluten. Gluten elicits, in genetically susceptible individuals, cytokine responses that are then transmitted to the immunocompetent cells. Vegetables and fruit have anti-inflammatory and antioxidant properties with a protective effect on intestinal epithelium. Read More

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http://dx.doi.org/10.1080/07315724.2018.1541426DOI Listing
February 2019

The emerging role of human TBK1 in virus-induced autophagy.

Autophagy 2019 Feb 22:1-2. Epub 2019 Feb 22.

a Department of Virology, Division of Medicine , Imperial College London , London , UK.

Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Read More

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http://dx.doi.org/10.1080/15548627.2019.1580513DOI Listing
February 2019

Phthalates and phthalate alternatives have diverse associations with oxidative stress and inflammation in pregnant women.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

Exposure to environmental chemicals such as phthalates has been linked to numerous adverse pregnancy outcomes, potentially through an oxidative stress mediated mechanism. Most research examined urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) as the oxidative stress biomarker. However, 8-iso-PGF2α also originates from enzymatic sources linked to inflammation. Read More

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http://dx.doi.org/10.1021/acs.est.8b05729DOI Listing
February 2019

Nanostructured fibrin agarose hydrogel as a novel hemostatic agent.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Instituto de Investigaciones Biomédicas de Sevilla, IBIS, (HUVR/CSIC/Universidad de Sevilla, Junta de Andalucía), Spain.

Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical hemostatic agents to overcome this issue therefore becomes necessary. Fibrin sealants are promising hemostatic agents due to their capacity to promote coagulation, but their effectiveness and applicability need to be improved. Read More

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http://dx.doi.org/10.1002/term.2831DOI Listing
February 2019

Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats.

Addict Biol 2019 Feb 22. Epub 2019 Feb 22.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward especially in brain regions that are involved in the reward system, but there is no document about relapse. Read More

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http://dx.doi.org/10.1111/adb.12740DOI Listing
February 2019

Comment on: Doxycycline in UK guidelines for hospital-acquired pneumonia: where is the evidence base?

J Antimicrob Chemother 2019 Feb 21. Epub 2019 Feb 21.

Regional Infectious Diseases Unit, Western General Hospital, NHS Lothian, Edinburgh, Scotland.

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http://dx.doi.org/10.1093/jac/dkz072DOI Listing
February 2019

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors.

Org Biomol Chem 2019 Feb 22. Epub 2019 Feb 22.

Normandie Univ, UNILEHAVRE, CNRS, URCOM, 76600 Le Havre, France.

Based on N-acyliminium species, two efficient and rapid approaches to diversify spirocyclic systems connected by two different carbon centers to the isoindole ring have been developed. The imide reduction and the tandem oxidative cleavage of olefin/formyl-amide equilibration were at first selected as the key steps for these strategies. Ultimately the intramolecular α-amidoalkylation reaction was achieved through the arylation of α-acetoxy lactams or α-hydroxy lactams using, respectively, a Lewis acid or a Brønsted acid depending on the nature of N-acyliminium precursors. Read More

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http://dx.doi.org/10.1039/c8ob02612bDOI Listing
February 2019

Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, PR China. and Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing 400067, PR China.

Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive flavonoid polyphenol with anti-inflammatory and anti-tumor activity. Read More

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http://dx.doi.org/10.1039/c8fo01615aDOI Listing
February 2019

Safety and tolerability of anifrolumab, a monoclonal antibody targeting type I interferon receptor, in Japanese patients with systemic lupus erythematosus: a multicenter, phase 2, open-label study.

Mod Rheumatol 2019 Feb 22:1-18. Epub 2019 Feb 22.

i Global Medicine Division , AstraZeneca Pharmaceuticals , USA .

Objectives: This study evaluated the safety and tolerability of anifrolumab, a monoclonal antibody targeting the type I interferon (IFN) receptor, in Japanese patients with moderate-to-severe systemic lupus erythematosus (SLE).

Methods: In this open-label, phase 2, dose-escalation study, patients received intravenous (IV) anifrolumab 100, 300, or 1000 mg every 4 weeks from Days 29 to 337 (Stage 1). Patients who completed Stage 1 continued anifrolumab 300 mg every 4 weeks for 156 weeks (Stage 2). Read More

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http://dx.doi.org/10.1080/14397595.2019.1583833DOI Listing
February 2019

Pannexin 1 channels contribute to IL-1β expression via NLRP3/Caspase-1 inflammasome in Aspergillus fumigatus keratitis.

Curr Eye Res 2019 Feb 22. Epub 2019 Feb 22.

a Department of Ophthalmology , the Affiliated Hospital of Qingdao University , Qingdao , Shandong Province , China , 266003.

Purpose: Pannexin 1 channels are deemed to play important roles in inflammation. However, there is limited information regarding their roles in fungal infection diseases, especially fungal keratitis. This study aimed to investigate the role of pannexin 1 channels in Aspergillus fumigatus (A. Read More

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http://dx.doi.org/10.1080/02713683.2019.1584321DOI Listing
February 2019

Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet.

Diabetes Metab J 2019 Feb;43(1):3-30

Division of Endocrinology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Read More

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http://dx.doi.org/10.4093/dmj.2018.0259DOI Listing
February 2019

β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P.R. China.

We previously reported that nucleotide-binding oligomerization domain-containing protein (NOD) 2 was involved in the inflammatory responses to cerebral ischaemia/reperfusion (I/R) insult. However, the mechanism by which NOD2 participates in brain ischaemic injury and the regulation of NOD2 in the process are still obscure. Increased β-arrestin 2 (ARRB2) expression was observed in microglia following cerebral I/R in wild-type mice besides the up-regulation of NOD2 and TRAF6. Read More

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http://dx.doi.org/10.1111/jcmm.14223DOI Listing
February 2019

Survival of adjacent-dental-implants in prediabetic and systemically healthy subjects at 5-years follow-up.

Clin Implant Dent Relat Res 2019 Feb 21. Epub 2019 Feb 21.

Department of Prosthetic-Dental-Science, College-of-Dentistry, King-Saud-University, Riyadh, Saudi-Arabia.

Background: Long-term survival of adjacent dental implants (ADI) in prediabetic patients remained uninvestigated.

Purpose: This 5 years' follow-up clinical study compared the survival of adjacent implants in prediabetic and nondiabetic subjects.

Materials And Methods: Prediabetic (group-A) and nondiabetic (group-B) subjects having undergone dental rehabilitation using ADI were assessed. Read More

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http://dx.doi.org/10.1111/cid.12715DOI Listing
February 2019

Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, Jinan, Shandong, China.

Endothelial dysfunction contributes to diabetic macrovascular complications, resulting in high mortality. Recent findings demonstrate a pathogenic role of P53 in endothelial dysfunction, encouraging the investigation of the effect of P53 inhibition on diabetic endothelial dysfunction. Thus, high glucose (HG)-treated endothelial cells (ECs) were subjected to pifithrin-α (PFT-α)-a specific inhibitor of P53, or P53-small interfering RNA (siRNA), both of which attenuated the HG-induced endothelial inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1111/jcmm.14253DOI Listing
February 2019

Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin.

J Biochem Mol Toxicol 2019 Feb 21:e22315. Epub 2019 Feb 21.

R&D Centre, Akay Flavours & Aromatics Pvt Ltd, Cochin, Kerala, India.

Alcoholic liver diseases are classified as one of the major reasons for worldwide morbidity and mortality. Curcuminoids exhibit a wide range of pharmacological activities that are beneficial for health, including hepatoprotective effects, but its clinical significance is limited due to poor oral bioavailability. In the present study, a novel formulation of curcumin as curcumin-galactomannosides (CGM) with enhanced oral bioavailability alleviated alcohol-induced liver damage in wistar rats with an increased potency compared to the unformulated natural curcuminoids (CM). Read More

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http://dx.doi.org/10.1002/jbt.22315DOI Listing
February 2019

Vascular and Non-vascular Contributors to Memory Reduction During Traumatic Brain Injury.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA.

Traumatic brain injury (TBI) is an increasing health problem. It is a complex, progressive disease that consists of many factors affecting memory. Studies have shown that increased blood-brain barrier (BBB) permeability initiates pathological changes in neuro-vascular network but the role of cerebrovascular dysfunction and its mediated mechanisms associated with memory reduction during TBI are still not well understood. Read More

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http://dx.doi.org/10.1111/ejn.14390DOI Listing
February 2019

Do Telomeres Influence Pace-of-Life-Strategies in Response to Environmental Conditions Over a Lifetime and Between Generations?

Bioessays 2019 Feb 21:e1800162. Epub 2019 Feb 21.

Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia.

The complexity of the physiological phenotype currently prevents us from identifying an integrative measure to assess how the internal state and environmental conditions modify life-history strategies. In this article, it is proposed that shorter telomeres should lead to a faster pace-of-life where investment in self-maintenance is decreased as a means of saving energy for reproduction, but at the cost of somatic durability. Inversely, longer telomeres would favor an increased investment in soma maintenance and thus a longer reproductive lifespan (i. Read More

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http://dx.doi.org/10.1002/bies.201800162DOI Listing
February 2019

Expression and Function of Macrophage-Inducible C-type Lectin (Mincle) in Inflammation Driven Parturition in Fetal Membranes and Myometrium.

Clin Exp Immunol 2019 Feb 21. Epub 2019 Feb 21.

Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.

The pivotal role of inflammatory processes in human parturition is well known, but not completely understood. We have performed a study to examine the role of Macrophage-inducible C-type lectin (Mincle) in inflammation-associated parturition. Using human samples, we show that spontaneous labor is associated with upregulated Mincle expression in the myometrium and fetal membranes. Read More

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http://dx.doi.org/10.1111/cei.13281DOI Listing
February 2019

Association between Fetuin-A and Prognosis of CAD: A Systematic Review and Meta-Analysis.

Eur J Clin Invest 2019 Feb 22:e13091. Epub 2019 Feb 22.

Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Fetuin-A is an anti-inflammation and anti-calcification factor involved in the course of coronary artery disease (CAD). But the association between serum fetuin-A level and the prognosis of CAD patients was still controversial. To clarify the association between serum fetuin-A level and the prognosis of CAD patients, we conducted the present meta-analysis. Read More

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http://dx.doi.org/10.1111/eci.13091DOI Listing
February 2019
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