3,287 results match your criteria Inflammation[Journal]


Interleukin-1β Induces Intracellular Serum Amyloid A1 Expression in Human Coronary Artery Endothelial Cells and Promotes its Intercellular Exchange.

Inflammation 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Vrazov trg 2, SI-1000, Ljubljana, Slovenia.

Serum amyloid A (SAA) is an acute-phase protein with important, pathogenic role in the development of atherosclerosis. Since dysfunctional endothelium represents a key early step in atherogenesis, we aimed to determine whether induced human coronary artery endothelial cells (HCAEC) modulate SAA1/2/4 expression and influence intracellular location and intercellular transport of SAA1. HCAEC were stimulated with 1 ng/ml IL-1β, 10 ng/ml IL-6, and/or 1 μM dexamethasone for 24 h. Read More

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http://dx.doi.org/10.1007/s10753-019-01003-3DOI Listing

(3R, 7R)-7-Acetoxyl-9-Oxo-de-O-Methyllasiodiplodin, a Secondary Metabolite of Penicillium Sp., Inhibits LPS-Mediated Inflammation in RAW 264.7 Macrophages through Blocking ERK/MAPKs and NF-κB Signaling Pathways.

Inflammation 2019 Apr 23. Epub 2019 Apr 23.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, 30 Qingquan Road of Laishan District, Yantai, 264005, Shandong, People's Republic of China.

Twelve polyketones were isolated from the fermentation broth of Penicillium sp., including six new compounds (supplementary material). Penicillium sp. Read More

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http://dx.doi.org/10.1007/s10753-019-01009-xDOI Listing

FSTL1 Promotes Inflammatory Reaction and Cartilage Catabolism through Interplay with NFκB Signaling Pathways in an In Vitro ONFH Model.

Authors:
Yuan Qu Yi Liu Rui Li

Inflammation 2019 Apr 22. Epub 2019 Apr 22.

Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, China.

Osteonecrosis of the femoral head (ONFH) usually occurs in young people and is closely associated with autoimmune reactions. Follistatin-like 1 (FSTL1) was recently proven to participate in several inflammation-related diseases. The role of FSTL1 in ONFH is still unclear. Read More

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http://dx.doi.org/10.1007/s10753-019-01012-2DOI Listing

Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation.

Inflammation 2019 Apr 22. Epub 2019 Apr 22.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.

The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA). As CFA induces long-lasting nociception characterized by peripheral and spinal cord inflammation, the anti-inflammatory activity of probucol was assessed at both foci. Probucol at 0. Read More

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http://dx.doi.org/10.1007/s10753-019-01011-3DOI Listing

Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin.

Inflammation 2019 Apr 22. Epub 2019 Apr 22.

Yenepoya Research Centre, Yenepoya University, Deralakatte, Mangalore, Karnataka, 575018, India.

Acute lung injury (ALI) is characterized by acute inflammation and tissue injury results in dysfunction of the alveolar epithelial membrane. If the epithelial injury is severe, a fibroproliferative phase of ALI can develop. During this phase, the activated fibroblast and myofibroblasts synthesize excessive collagenous extracellular matrix that leads to a condition called pulmonary fibrosis. Read More

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http://dx.doi.org/10.1007/s10753-019-01010-4DOI Listing

Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.

Inflammation 2019 Apr 17. Epub 2019 Apr 17.

Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.

Sudachitin, a polymethoxylated flavonoid found in the skin of Citrus sudachi, is a biologically active substance. The aim of this study was to examine whether sudachitin could be used to inhibit the expression of matrix metalloproteinase (MMP)-1 and MMP-3, which are involved in the destruction of periodontal tissues in periodontal lesions, in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Sudachitin suppressed TNF-α-induced MMP-1 and MMP-3 production in HPDLC. Read More

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http://dx.doi.org/10.1007/s10753-019-01007-zDOI Listing

Pro-inflammatory S100A9 Protein: a Double-Edged Sword in Cancer?

Inflammation 2019 Apr 5. Epub 2019 Apr 5.

Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s10753-019-00981-8DOI Listing

Aquaporin 4 Blockade Attenuates Acute Lung Injury Through Inhibition of Th17 Cell Proliferation in Mice.

Inflammation 2019 Apr 3. Epub 2019 Apr 3.

Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Acute lung injury (ALI) is a syndrome characterized by damage to the alveolar-capillary wall, pulmonary edema and recruitment of inflammatory cells. Previous studies have indicated that aquaporin 4 (AQP4) plays a key role in brain edema formation and resolution. However, the role of AQP4 in the development and progression of ALI is not clear and needs to be resolved. Read More

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http://dx.doi.org/10.1007/s10753-019-01002-4DOI Listing
April 2019
1 Read

Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation.

Inflammation 2019 Apr 2. Epub 2019 Apr 2.

Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 518 Ziyue RD, Minhang District, Shanghai, 200241, China.

Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present study, we investigated the anti-inflammatory effect of tizoxanide on lipopolysaccharide (LPS)-stimulated RAW264. Read More

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http://dx.doi.org/10.1007/s10753-019-00994-3DOI Listing

Targeting NLRP3 Inflammasome in Inflammatory Bowel Disease: Putting out the Fire of Inflammation.

Inflammation 2019 Apr 1. Epub 2019 Apr 1.

Department of Gastroenterology, General Hospital of the Chinese People's Liberation Army, Beijing, China.

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, comprised of ulcerative colitis and Crohn's disease. Among the complicated pathogenic factors of IBD, the overaction of inflammatory and immune reaction serves as an important factor. Inflammasome is a form of innate immunity as well as inflammation. Read More

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http://dx.doi.org/10.1007/s10753-019-01008-yDOI Listing
April 2019
2 Reads

Formononetin Antagonizes the Interleukin-1β-Induced Catabolic Effects Through Suppressing Inflammation in Primary Rat Chondrocytes.

Inflammation 2019 Apr 1. Epub 2019 Apr 1.

Oral Biology Research Institute, School of Dentistry, Chosun University, 309 Philmun-daero, Dong-gu, Gwangju, 61452, Republic of Korea.

In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1β (IL-1β)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. Formononetin did not affect the viability of primary rat chondrocytes in both short- (24 h) and long-term (21 days) treatment periods. Furthermore, formononetin effectively antagonized the IL-1β-induced catabolic effects including the decrease in proteoglycan content, suppression of pericellular matrix formation, and loss of proteoglycan through the decreased expression of cartilage-degrading enzymes like matrix metalloproteinase (MMP)-13, MMP-1, and MMP-3 in primary rat chondrocytes. Read More

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http://dx.doi.org/10.1007/s10753-019-01005-1DOI Listing
April 2019
4 Reads

Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.

Inflammation 2019 Mar 27. Epub 2019 Mar 27.

Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, No.18 Zhongshan Road II, Baise, 533000, Guangxi Zhuang Autonomous Region, China.

Injury to podocytes leads to proteinuria, a hallmark of most glomerular diseases as well as being associated with the progression of kidney disease. Activation of the Wnt/β-catenin pathway is associated with the pathogenesis of podocyte dysfunction and can play a role in renal injury. Furthermore, the expression of fractalkine (FKN) induced by lipopolysaccharides (LPS) is also one of crucial inflammation factors closely related to renal tissue damage. Read More

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http://dx.doi.org/10.1007/s10753-019-00988-1DOI Listing
March 2019
1 Read

Sodium Butyrate Ameliorates Intestinal Injury and Improves Survival in a Rat Model of Cecal Ligation and Puncture-Induced Sepsis.

Inflammation 2019 Mar 23. Epub 2019 Mar 23.

Department of Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, China.

Sepsis is a life-threatening condition with a high rate of mortality. Unfortunately, very few therapies can improve outcomes in patients with sepsis. Butyrate, which is the most potent histone deacetylase (HDAC) inhibitor among short-chain fatty acids, exerts anti-inflammatory effects in a variety of inflammatory diseases. Read More

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http://dx.doi.org/10.1007/s10753-019-00987-2DOI Listing

Correction to: miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis.

Inflammation 2019 Mar 22. Epub 2019 Mar 22.

College of Laboratory Medicine, Dalian Medical University, 9 Lushunnan Road Xiduan, Dalian, 116044, Liaoning Province, China.

The original version of this article contained mistakes, and the authors would like to correct them. Read More

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http://dx.doi.org/10.1007/s10753-019-01001-5DOI Listing
March 2019
1 Read

The Deleterious Impact of Interleukin 9 to Hepatorenal Physiology.

Inflammation 2019 Mar 19. Epub 2019 Mar 19.

Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Rua Piauí, Bloco 2B, sala 2B200, Uberlândia, MG, Brazil.

IL-9 is a pleiotropic cytokine, recently recognized as belonging to Th9 cells that are involved in various pathologies. We aimed to evaluate the role of IL-9 in the course of hepatic and renal fibrosis. Female C57BL/6 mice were treated subcutaneously with IL-9 10 ng/mouse and 20 ng/mouse for 40 days, alternating every 5 days each application, the negative control of which was treated with PBS and positive control with CCL. Read More

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http://dx.doi.org/10.1007/s10753-019-00997-0DOI Listing

Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model.

Inflammation 2019 Mar 19. Epub 2019 Mar 19.

Trauma center/Department of Emergency and Traumatic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 1095 Jiefang avenue, Wuhan, 430030, Hubei Province, China, People's Republic of China.

Increasing evidence demonstrates that pyroptosis, pro-inflammatory programmed cell death, is linked to acute lung injury (ALI). Dihydromyricetin (DHM) has been reported to exert anti-inflammatory effects by inhibiting NLRP3 inflammasome activation in vascular endothelial cells. However, the effects of DHM on NLRP3 inflammasome-induced pyroptosis in ALI remain elusive. Read More

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http://dx.doi.org/10.1007/s10753-019-00990-7DOI Listing
March 2019
1 Read
1.921 Impact Factor

CTRP3 Alleviates Ox-LDL-Induced Inflammatory Response and Endothelial Dysfunction in Mouse Aortic Endothelial Cells by Activating the PI3K/Akt/eNOS Pathway.

Inflammation 2019 Mar 19. Epub 2019 Mar 19.

Central Laboratory, Gansu Provincial Hospital of TCM, Lanzhou, 730050, Gansu, People's Republic of China.

C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel, certified, adipokine that beneficially regulates metabolism and inflammation in the cardiovascular system. Atherosclerotic plaque rupturing and secondary thrombosis cause vascular disorders, such as myocardial infarction and unstable angina. However, the underlying role of CTRP3 in atherosclerosis remains unclear. Read More

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http://dx.doi.org/10.1007/s10753-019-00996-1DOI Listing
March 2019
1 Read

Severe Burn Injury Progression and Phasic Changes of Gene Expression in Mouse Model.

Inflammation 2019 Mar 16. Epub 2019 Mar 16.

Department of Burn and Plastic Surgery, Zibo Central Hospital, Gongqingtuanxi Road, Zhangdian District, Zibo, 255036, Shandong, China.

Patients with severe burns are susceptible to infectious complications including burn-site infections and sepsis. The purpose of this study was to explore the pathologic development of burn injury in a mouse model and to screen genes dysregulated at different time points on the basis of gene expression microarrays. Differential expression analysis identified a total 223 genes that related to only time progression independent of burn injury and 214 genes with aberrant expression due to burn injury. Read More

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http://link.springer.com/10.1007/s10753-019-00984-5
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http://dx.doi.org/10.1007/s10753-019-00984-5DOI Listing
March 2019
8 Reads

Anti-inflammatory Activity of Methanolic Extract and an Alkaloid from Palicourea crocea (Sw.) Roem and Schult.

Inflammation 2019 Mar 16. Epub 2019 Mar 16.

Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados UFGD, Dourados, Mato Grosso do Sul State, Brazil.

Palicourea crocea (Sw.) Roem. and Schult. Read More

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http://dx.doi.org/10.1007/s10753-019-00966-7DOI Listing
March 2019
5 Reads

Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest.

Inflammation 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.

Leukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migration in vitro and in vivo. Read More

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http://dx.doi.org/10.1007/s10753-019-00985-4DOI Listing
March 2019
3 Reads

Heteroleptic Ruthenium Polypyridyl Complex Had Differential Effects on the Production of Pro-inflammatory Cytokines TNFα, IL1β, and IL6 by the Mammalian Macrophages In Vitro.

Authors:
Furkan Ayaz

Inflammation 2019 Mar 8. Epub 2019 Mar 8.

Department of Biotechnology, Faculty of Arts and Science, Mersin University, 33110, Mersin, Turkey.

Modulation of the immune system has gathered more attention in the field of medicine due to the immense potential that it presents. Our immune system has important roles against cancer to infectious diseases, as well as in the development of autoimmune disorders. Therefore, being able to manipulate our immune system cells would enable us to determine the type and strength of the immune response to certain danger stimuli. Read More

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http://dx.doi.org/10.1007/s10753-019-00999-yDOI Listing
March 2019
2 Reads

Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-κB Pathway in Rats.

Inflammation 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiovascular Medicine, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, No. 99, Longcheng Street, Taiyuan, 030032, Shanxi Province, People's Republic of China.

Signal transducer and activator of transcription 4 (STAT4) has been implicated in the progression of myocarditis. The aim of the current study was to investigate the role by which STAT4 influences autoimmune myocarditis in an attempt to identify a theoretical therapeutic perspective for the condition. After successful establishment of an autoimmune myocarditis rat model, the expression patterns of STAT4, NF-κB pathway-related genes, Th1 inflammatory cytokines (IFN-γ and IL-2), and Th2 inflammatory cytokines (IL-6 and IL-10) were subsequently determined. Read More

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http://dx.doi.org/10.1007/s10753-019-00978-3DOI Listing
March 2019
1 Read

TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response.

Inflammation 2019 Mar 7. Epub 2019 Mar 7.

Department of Infectious Disease, Qilu Hospital of Shandong University, 107# West Wenhua Road, Jinan, 250012, Shandong province, People's Republic of China.

Type I interferon (IFN) response is central for host defense against viral infection. Tripartite motif 27 (TRIM27) is implicated in antiviral innate immune response; however, whether it affects the replication of hepatitis C virus (HCV) and the underlying mechanisms remain uncharacterized. Here, we show that TRIM27 expression is induced in Huh7. Read More

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http://dx.doi.org/10.1007/s10753-019-00992-5DOI Listing

Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling.

Inflammation 2019 Mar 7. Epub 2019 Mar 7.

Department of Orthopedic Surgery, Second Clinical College, Dalian Medical University, No. 222 Zhongshan Road, Dalian, 116011, China.

Sinomenine (SIN) has been shown to protect against IL-1β-induced chondrocyte apoptosis in vitro. However, the role of SIN in the anterior cruciate ligament transection (ACLT)-induced osteoarthritis (OA) mouse model and its underlying molecular mechanisms remain unclear. In the present study, the protective effect of SIN on ACLT-induced articular cartilage degeneration and IL-1β-induced chondrocyte apoptosis miR-223-3p/NLRP3 signaling regulation was investigated. Read More

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http://dx.doi.org/10.1007/s10753-019-00986-3DOI Listing
March 2019
1 Read

Correction to: Plumbagin Prevents IL-1β-Induced Inflammatory Response in Human Osteoarthritis Chondrocytes and Prevents the Progression of Osteoarthritis in Mice.

Inflammation 2019 Mar 4. Epub 2019 Mar 4.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325000, China.

The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below. Read More

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http://dx.doi.org/10.1007/s10753-019-00989-0DOI Listing

Amelioration of Lipopolysaccharide-Induced Nephrotic Proteinuria by NFAT5 Depletion Involves Suppressed NF-κB Activity.

Inflammation 2019 Mar 2. Epub 2019 Mar 2.

Department of Pediatric Cardiology, The First Hospital of Jilin University, No. 71 of Xin Min Street, Chang Chun, 130021, Jilin Province, China.

Idiopathic nephrotic syndrome (INS) is characterized by proteinuria, in which podocyte dysfunction associated with NF-κB-mediated inflammation plays an important role. The nuclear factor of activated T cells 5 (NFAT5) has been shown to enhance NF-κB activity. However, whether NFAT5 is associated with proteinuria remains uncharacterized. Read More

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http://dx.doi.org/10.1007/s10753-019-00993-4DOI Listing
March 2019
1 Read

Targeting of IL-6-Relevant Long Noncoding RNA Profiles in Inflammatory and Tumorous Disease.

Inflammation 2019 Mar 2. Epub 2019 Mar 2.

Department of Urology, The Second Affiliated Hospital, Harbin Medical University, 246 Xuefu St., Nan Gang District, Harbin, China.

Interleukin-6 (IL-6) is a critical cytokine with a diverse repertoire of physiological functions. Dysregulation of IL-6 signaling is associated with inflammatory disorders as well as cancers. However, blockade of IL-6 activity via antibodies directed against the IL-6 signaling pathway may compromise the efficacy of the immune system; therefore, patients may not have a uniformly satisfactory response to treatment. Read More

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http://link.springer.com/10.1007/s10753-019-00995-2
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http://dx.doi.org/10.1007/s10753-019-00995-2DOI Listing
March 2019
3 Reads

Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells.

Inflammation 2019 Mar 1. Epub 2019 Mar 1.

Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8504, Japan.

Carnosic acid, which is a bioactive compound isolated from rosemary, has various pharmacological effects. However, the anti-inflammatory effect of carnosic acid on periodontitis is still unknown. The aim of this study was to investigate the effect of carnosic acid on CXC chemokine receptor 3 (CXCR3) ligands, which are involved in Th1 cells migration and accumulation, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). Read More

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http://dx.doi.org/10.1007/s10753-019-00991-6DOI Listing

Regulatory T Cells Could Improve Intestinal Barrier Dysfunction in Heatstroke.

Inflammation 2019 Mar 1. Epub 2019 Mar 1.

Critical Care Medicine, Chinese PLA General Hospital, 28th Fuxing Road, Haidian District, Beijing, 100853, China.

Intestinal barrier dysfunction plays a pivotal role in multiorgan dysfunction during heatstroke (HS). Neutrophils are involved in intestinal inflammation and thus dampen the mucosal integrity. Regulatory T cells (Tregs) have been shown to orchestrate neutrophils and thus sustain mucosal integrity in miscellaneous inflammation-related diseases. Read More

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http://dx.doi.org/10.1007/s10753-019-00983-6DOI Listing
March 2019
1 Read

Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (MS) Patients In Vitro.

Inflammation 2019 Feb 26. Epub 2019 Feb 26.

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran.

Dysregulation of the immune system and impairment in the function and number of patient-derived regulatory T cells (Treg) have an important role in multiple sclerosis (MS) pathogenesis. MS patients still receive different medications to overcome the relapses and to slow the disease progression. However, the benefits of these therapies are limited and are accompanied by different side effects. Read More

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http://dx.doi.org/10.1007/s10753-019-00980-9DOI Listing
February 2019
1.921 Impact Factor

MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion.

Inflammation 2019 Feb 26. Epub 2019 Feb 26.

School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

The tumour microenvironment predominantly consists of macrophages with phenotypes ranging from pro-inflammatory (M1-like) to anti-inflammatory (M2-like). Trehalose-6,6'-dibehenate (TDB) displays moderate anti-tumour activity and stimulates M1-like macrophages via the macrophage inducible C-type lectin (Mincle) resulting in IL-1β production. In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1β production by TDB-stimulated macrophages. Read More

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http://dx.doi.org/10.1007/s10753-019-00976-5DOI Listing
February 2019

α7nAChR Deletion Aggravates Myocardial Infarction and Enhances Systemic Inflammatory Reaction via mTOR-Signaling-Related Autophagy.

Inflammation 2019 Feb 26. Epub 2019 Feb 26.

Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 261 HuanSha Road, Hangzhou, Zhejiang, China.

Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been previously reported to play an alleviative role in myocardial infarction (MI). In this study, we investigated its specific mechanism. α7nAChR mice and its control (α7nAChR) were used for the study of α7nAChR. Read More

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http://dx.doi.org/10.1007/s10753-019-00979-2DOI Listing
February 2019
1 Read

Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease.

Authors:
Rong Song Lexun Lin

Inflammation 2019 Feb 22. Epub 2019 Feb 22.

Department of Microbiology, Harbin Medical University, Harbin, 150081, China.

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein that can modulate osteoblasts and bone mineralization. Periodontal disease (PD) is characterized by gum inflammation, alveolar bone resorption, and tooth loss. In this study, we found that GPNMB is highly expressed in inflamed periodontal tissue through microarray and immunohistochemistry (IHC) assays. Read More

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http://dx.doi.org/10.1007/s10753-019-00977-4DOI Listing
February 2019
1 Read

Periodontal Injection of Lipopolysaccharide Promotes Arthritis Development in Mice.

Inflammation 2019 Feb 19. Epub 2019 Feb 19.

Centre for Gout and Metabolic Bone and Joint Diseases, Rheumatology, SS Giovanni and Paolo Hospital, Venice, Italy.

This study evaluated the arthritogenic effect of lipopolysaccharide (LPS) in a mouse model of periodontal disease. Periodontitis was induced in wild-type CD1 mice by nine LPS injections (10 or 50 ng) into the maxillary mucosa. Untreated mice or injected with LPS at the tail were used as controls. Read More

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http://dx.doi.org/10.1007/s10753-019-00975-6DOI Listing
February 2019
4 Reads

Correction to: The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Inflammation 2019 Feb 15. Epub 2019 Feb 15.

Postgraduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.

After publication of our article it came to our attention that it contains a number of errors with regard to the citations. The details are provided below. Read More

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http://link.springer.com/10.1007/s10753-019-00974-7
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http://dx.doi.org/10.1007/s10753-019-00974-7DOI Listing
February 2019
2 Reads
1.921 Impact Factor

Umbelliferone Ameliorates CCl-Induced Liver Fibrosis in Rats by Upregulating PPARγ and Attenuating Oxidative Stress, Inflammation, and TGF-β1/Smad3 Signaling.

Inflammation 2019 Feb 11. Epub 2019 Feb 11.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Umbelliferone (UMB) is a natural coumarin that has diverse biological activities. However, its potential to protect against liver fibrosis has not been reported yet. This study aimed to investigate the protective effect of UMB against carbon tetrachloride (CCl)-induced liver fibrosis in rats. Read More

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http://dx.doi.org/10.1007/s10753-019-00973-8DOI Listing
February 2019
1 Read

Correction to: Immunometabolism: Another Road to Sepsis and its Therapeutic Targeting.

Authors:
Vijay Kumar

Inflammation 2019 Feb 9. Epub 2019 Feb 9.

Children's Health Queensland Clinical Unit, Department of Paediatrics and Child Care, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, QLD, 4078, Australia.

The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below: In the published article, the subheading "Immunometabolic Reprogramming Among MDSCs During Sepsis" should read as "Immunometabolic Reprogramming Among Endothelial Cells or ECs During Sepsis". Read More

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http://link.springer.com/10.1007/s10753-019-00970-x
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http://dx.doi.org/10.1007/s10753-019-00970-xDOI Listing
February 2019
5 Reads
1.921 Impact Factor

Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis.

Inflammation 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The most epidemic liver disorder non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis and inflammation with hepatocellular damage. Recently, it is predictable to be the extensive cause for liver transplantation. The absence of an approved therapeutic agent for NASH is the reason for investigating saroglitazar (SAR) which showed promising effects as a dual PPAR-α/γ agonist in recent studies on NASH. Read More

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http://dx.doi.org/10.1007/s10753-019-00967-6DOI Listing
February 2019
3 Reads

Attenuation of Sepsis-Induced Cardiomyopathy by Regulation of MicroRNA-23b Is Mediated Through Targeting of MyD88-Mediated NF-κB Activation.

Inflammation 2019 Feb 8. Epub 2019 Feb 8.

Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300054, China.

Myocardial cell injury or cardiomyopathy is associated with excessive inflammatory response and apoptosis of cardiac myocytes during sepsis. MicroRNA-23b (miR-23b) is a multifunctional miRNA that is considered to regulate immunosuppression in sepsis. The aim of this study was to examine the effect of miR-23b on cardiomyopathy induced by sepsis and to explore the potential mechanism involved. Read More

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http://dx.doi.org/10.1007/s10753-019-00958-7DOI Listing
February 2019
2 Reads

Correction to: Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis through miR-17-5p Downregulating TLR4.

Inflammation 2019 04;42(2):740

Department of Emergency, People's Hospital of Ningxia Hui Autonomous Region, the First Affiliated Hospital of Northwest University for Nationalities, No.301 Zhengyuan North Street, Yinchuan, 750000, Ningxia, China.

The original version of this article contained mistakes, and the authors would like to correct them. Read More

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http://dx.doi.org/10.1007/s10753-019-00972-9DOI Listing
April 2019
1.921 Impact Factor

High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.

Inflammation 2019 Apr;42(2):471-484

Department of Respiratory, The 2nd Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan, China.

Paraquat (PQ) intoxication seriously endangers human beings' health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes cell apoptosis, necrosis as well as ROS generation in a dose dependent manner. Of note, low-dose PQ (50 μM) induces cell autophagy, increases Nrf2 as well as p65 levels and has little impacts on Keap1, while high-dose PQ (500 μM) inhibits autophagy, upregulates Keap1 as well as downregulates p65 and Nrf2. Read More

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http://dx.doi.org/10.1007/s10753-018-00956-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449493PMC
April 2019
2 Reads

Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo.

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is a natural bioactive compound with anti-inflammatory effects in different diseases, including inhibition of the inflammatory response in chondrocytes, whose morphology and avascular supply are similar to those of NP cells. Therefore, we hypothesized that baicalein may have a therapeutic effect on IDD by suppressing the inflammatory response. Read More

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http://dx.doi.org/10.1007/s10753-019-00965-8DOI Listing
February 2019

Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway.

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, 07084, South Korea.

This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s10753-019-00971-wDOI Listing
February 2019
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Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.

Inflammation 2019 Feb 6. Epub 2019 Feb 6.

Department of Anesthesiology, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes. Read More

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http://dx.doi.org/10.1007/s10753-019-00969-4DOI Listing
February 2019
1.921 Impact Factor

MicroRNA-155 Mediates Obesity-Induced Renal Inflammation and Dysfunction.

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Chronic inflammation is a major contributor to obesity-related renal damage. Recent studies have demonstrated that microRNA (miR)-155 is closely associated with hyperglycemia-induced nephropathy, but whether renal miR-155 participates in the inflammatory response and development of obesity-related nephropathy is unknown. In present study, we investigated the pathophysiological role of renal miR-155 in palmitic acid (PA)-treated endothelial cell and high-fat-diet (HFD)-fed mouse models by specific miR-155 sponge. Read More

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http://dx.doi.org/10.1007/s10753-019-00961-yDOI Listing
February 2019
2 Reads

Chinese Birch Pollen Allergy and Immunotherapy in Mice.

Authors:
Zhijuan Xie Jia Yin

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Wang Fu Jing Street, Beijing, 100730, China.

Birch pollen allergy is a common cause of spring pollinosis in China. However, there is little research on birch pollen allergen in China and only the major allergen (Bet v 1) has been fully characterized. Chinese birch pollen-induced airway inflammation models in BALB/c mice were developed and administered subcutaneous immunotherapy (SCIT). Read More

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http://dx.doi.org/10.1007/s10753-019-00957-8DOI Listing
February 2019
1 Read

Novel Treatment of Experimental Autoimmune Prostatitis by Nanoparticle-Conjugated Autoantigen Peptide T2.

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China.

The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. Fifty male C57BL/6 mice were randomly divided into five groups of ten mice each. Read More

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http://dx.doi.org/10.1007/s10753-019-00968-5DOI Listing
February 2019
3 Reads
1.921 Impact Factor

DPP-4 Inhibition Leads to Decreased Pancreatic Inflammatory Profile and Increased Frequency of Regulatory T Cells in Experimental Type 1 Diabetes.

Inflammation 2019 Apr;42(2):449-462

Departmento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rua Alexandre Baraúna, 949, Fortaleza, Ceará, 60430-160, Brazil.

Sitagliptin is a dipeptidyl peptidase-4 inhibitor (iDPP-4), which has been used for type 2 diabetes treatment. Recently, iDPP-4 has been described as a promising treatment of type 1 diabetes (T1D) but is still necessary to evaluate immune effects of sitagliptin. C57BL/6 mice were induced by multiple low doses of streptozotocin. Read More

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http://dx.doi.org/10.1007/s10753-018-00954-3DOI Listing
April 2019
2 Reads

Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.

Inflammation 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory Medicine, Xuzhou Medical University Affiliated Hospital of Lianyungang, No.182 North Tongguan Road, Lianyungang, 222002, China.

Umbilical cord blood mesenchymal stem cells (UCB-MSCs) have been shown to be a source of stem cells for use in cellular therapies and have immunomodulatory effects on several immune cells in an inflammatory environment. However, whether UCB-MSCs have immunomodulatory effects against lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in macrophages and whether it is involved in phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway remain unclear. After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Read More

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http://dx.doi.org/10.1007/s10753-019-00960-zDOI Listing
February 2019
1 Read

Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions.

Inflammation 2019 Jan 31. Epub 2019 Jan 31.

Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Among the clinical manifestations observed in septic patients, sepsis-associated encephalopathy (SAE) is probably the most obscure and poorly explored. It is well established, however, that SAE is more prevalent in aged individuals and related to a worse outcome. In this context, we decided to investigate the acute effects of sepsis, induced by cecal ligation and puncture (CLP), on the cerebral transcriptional profile of young and old rats. Read More

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http://link.springer.com/10.1007/s10753-019-00964-9
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http://dx.doi.org/10.1007/s10753-019-00964-9DOI Listing
January 2019
13 Reads