3,253 results match your criteria Inflammation[Journal]


Correction to: The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Inflammation 2019 Feb 15. Epub 2019 Feb 15.

Postgraduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.

After publication of our article it came to our attention that it contains a number of errors with regard to the citations. The details are provided below. Read More

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http://dx.doi.org/10.1007/s10753-019-00974-7DOI Listing
February 2019

Umbelliferone Ameliorates CCl-Induced Liver Fibrosis in Rats by Upregulating PPARγ and Attenuating Oxidative Stress, Inflammation, and TGF-β1/Smad3 Signaling.

Inflammation 2019 Feb 11. Epub 2019 Feb 11.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Umbelliferone (UMB) is a natural coumarin that has diverse biological activities. However, its potential to protect against liver fibrosis has not been reported yet. This study aimed to investigate the protective effect of UMB against carbon tetrachloride (CCl)-induced liver fibrosis in rats. Read More

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http://dx.doi.org/10.1007/s10753-019-00973-8DOI Listing
February 2019

Correction to: Immunometabolism: Another Road to Sepsis and its Therapeutic Targeting.

Authors:
Vijay Kumar

Inflammation 2019 Feb 9. Epub 2019 Feb 9.

Children's Health Queensland Clinical Unit, Department of Paediatrics and Child Care, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, QLD, 4078, Australia.

The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below: In the published article, the subheading "Immunometabolic Reprogramming Among MDSCs During Sepsis" should read as "Immunometabolic Reprogramming Among Endothelial Cells or ECs During Sepsis". Read More

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http://link.springer.com/10.1007/s10753-019-00970-x
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http://dx.doi.org/10.1007/s10753-019-00970-xDOI Listing
February 2019
1 Read

Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis.

Inflammation 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The most epidemic liver disorder non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis and inflammation with hepatocellular damage. Recently, it is predictable to be the extensive cause for liver transplantation. The absence of an approved therapeutic agent for NASH is the reason for investigating saroglitazar (SAR) which showed promising effects as a dual PPAR-α/γ agonist in recent studies on NASH. Read More

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http://dx.doi.org/10.1007/s10753-019-00967-6DOI Listing
February 2019
1 Read

Attenuation of Sepsis-Induced Cardiomyopathy by Regulation of MicroRNA-23b Is Mediated Through Targeting of MyD88-Mediated NF-κB Activation.

Inflammation 2019 Feb 8. Epub 2019 Feb 8.

Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300054, China.

Myocardial cell injury or cardiomyopathy is associated with excessive inflammatory response and apoptosis of cardiac myocytes during sepsis. MicroRNA-23b (miR-23b) is a multifunctional miRNA that is considered to regulate immunosuppression in sepsis. The aim of this study was to examine the effect of miR-23b on cardiomyopathy induced by sepsis and to explore the potential mechanism involved. Read More

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http://dx.doi.org/10.1007/s10753-019-00958-7DOI Listing
February 2019

Correction to: Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis through miR-17-5p Downregulating TLR4.

Inflammation 2019 Feb 8. Epub 2019 Feb 8.

Department of Emergency, People's Hospital of Ningxia Hui Autonomous Region, the First Affiliated Hospital of Northwest University for Nationalities, No.301 Zhengyuan North Street, Yinchuan, 750000, Ningxia, China.

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http://dx.doi.org/10.1007/s10753-019-00972-9DOI Listing
February 2019
1.921 Impact Factor

High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.

Inflammation 2019 Feb 8. Epub 2019 Feb 8.

Department of Respiratory, The 2nd Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan, China.

Paraquat (PQ) intoxication seriously endangers human beings' health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes cell apoptosis, necrosis as well as ROS generation in a dose dependent manner. Of note, low-dose PQ (50 μM) induces cell autophagy, increases Nrf2 as well as p65 levels and has little impacts on Keap1, while high-dose PQ (500 μM) inhibits autophagy, upregulates Keap1 as well as downregulates p65 and Nrf2. Read More

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http://dx.doi.org/10.1007/s10753-018-00956-1DOI Listing
February 2019

Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo.

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is a natural bioactive compound with anti-inflammatory effects in different diseases, including inhibition of the inflammatory response in chondrocytes, whose morphology and avascular supply are similar to those of NP cells. Therefore, we hypothesized that baicalein may have a therapeutic effect on IDD by suppressing the inflammatory response. Read More

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http://dx.doi.org/10.1007/s10753-019-00965-8DOI Listing
February 2019

Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway.

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, 07084, South Korea.

This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s10753-019-00971-wDOI Listing
February 2019

Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.

Inflammation 2019 Feb 6. Epub 2019 Feb 6.

Department of Anesthesiology, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes. Read More

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http://dx.doi.org/10.1007/s10753-019-00969-4DOI Listing
February 2019

MicroRNA-155 Mediates Obesity-Induced Renal Inflammation and Dysfunction.

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Chronic inflammation is a major contributor to obesity-related renal damage. Recent studies have demonstrated that microRNA (miR)-155 is closely associated with hyperglycemia-induced nephropathy, but whether renal miR-155 participates in the inflammatory response and development of obesity-related nephropathy is unknown. In present study, we investigated the pathophysiological role of renal miR-155 in palmitic acid (PA)-treated endothelial cell and high-fat-diet (HFD)-fed mouse models by specific miR-155 sponge. Read More

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http://dx.doi.org/10.1007/s10753-019-00961-yDOI Listing
February 2019

Chinese Birch Pollen Allergy and Immunotherapy in Mice.

Authors:
Zhijuan Xie Jia Yin

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Wang Fu Jing Street, Beijing, 100730, China.

Birch pollen allergy is a common cause of spring pollinosis in China. However, there is little research on birch pollen allergen in China and only the major allergen (Bet v 1) has been fully characterized. Chinese birch pollen-induced airway inflammation models in BALB/c mice were developed and administered subcutaneous immunotherapy (SCIT). Read More

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http://dx.doi.org/10.1007/s10753-019-00957-8DOI Listing
February 2019
1 Read

Novel Treatment of Experimental Autoimmune Prostatitis by Nanoparticle-Conjugated Autoantigen Peptide T2.

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China.

The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. Fifty male C57BL/6 mice were randomly divided into five groups of ten mice each. Read More

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http://dx.doi.org/10.1007/s10753-019-00968-5DOI Listing
February 2019
2 Reads
1.921 Impact Factor

DPP-4 Inhibition Leads to Decreased Pancreatic Inflammatory Profile and Increased Frequency of Regulatory T Cells in Experimental Type 1 Diabetes.

Inflammation 2019 Feb 1. Epub 2019 Feb 1.

Departmento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rua Alexandre Baraúna, 949, Fortaleza, Ceará, 60430-160, Brazil.

Sitagliptin is a dipeptidyl peptidase-4 inhibitor (iDPP-4), which has been used for type 2 diabetes treatment. Recently, iDPP-4 has been described as a promising treatment of type 1 diabetes (T1D) but is still necessary to evaluate immune effects of sitagliptin. C57BL/6 mice were induced by multiple low doses of streptozotocin. Read More

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http://dx.doi.org/10.1007/s10753-018-00954-3DOI Listing
February 2019

Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.

Inflammation 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory Medicine, Xuzhou Medical University Affiliated Hospital of Lianyungang, No.182 North Tongguan Road, Lianyungang, 222002, China.

Umbilical cord blood mesenchymal stem cells (UCB-MSCs) have been shown to be a source of stem cells for use in cellular therapies and have immunomodulatory effects on several immune cells in an inflammatory environment. However, whether UCB-MSCs have immunomodulatory effects against lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in macrophages and whether it is involved in phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway remain unclear. After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Read More

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http://dx.doi.org/10.1007/s10753-019-00960-zDOI Listing
February 2019

Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions.

Inflammation 2019 Jan 31. Epub 2019 Jan 31.

Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Among the clinical manifestations observed in septic patients, sepsis-associated encephalopathy (SAE) is probably the most obscure and poorly explored. It is well established, however, that SAE is more prevalent in aged individuals and related to a worse outcome. In this context, we decided to investigate the acute effects of sepsis, induced by cecal ligation and puncture (CLP), on the cerebral transcriptional profile of young and old rats. Read More

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http://link.springer.com/10.1007/s10753-019-00964-9
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http://dx.doi.org/10.1007/s10753-019-00964-9DOI Listing
January 2019
3 Reads

PP2ACα of Alveolar Macrophages Is a Novel Protective Factor for LPS-Induced Acute Respiratory Distress Syndrome.

Inflammation 2019 Jan 25. Epub 2019 Jan 25.

Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, 548 Binwen Rd, Hangzhou, 310053, China.

Protein phosphatase 2A (PP2A) is one main serine/threonine phosphatase in eukaryotes, and its activation changes have been linked to modulation of numerous pathological processes, such as cancer, inflammation, fibrosis, and neurodegenerative diseases. Acute respiratory distress syndrome (ARDS), the major cause of respiratory failure, remains with limited therapies available up to now. Alveolar macrophages (AMs) are essential to innate immunity and host defense, participating in the pathogenesis of ARDS. Read More

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http://link.springer.com/10.1007/s10753-019-00962-x
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http://dx.doi.org/10.1007/s10753-019-00962-xDOI Listing
January 2019
4 Reads

Sevoflurane Prevents Airway Remodeling via Downregulation of VEGF and TGF-β1 in Mice with OVA-Induced Chronic Airway Inflammation.

Inflammation 2019 Jan 24. Epub 2019 Jan 24.

Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui, China.

Asthma is characterized by chronic airway inflammation, which is the underlying cause of airway remodeling featured by goblet cell hyperplasia, subepithelial fibrosis, and proliferation of smooth muscle. Sevoflurane has been used to treat life-threatening asthma and our previous study shows that sevoflurane inhibits acute lung inflammation in ovalbumin (OVA)-induced allergic mice. However, the effect of sevoflurane on airway remodeling in the context of chronic airway inflammation and the underlying mechanism are still unknown. Read More

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http://dx.doi.org/10.1007/s10753-019-00963-wDOI Listing
January 2019

Calgranulin B and KL-6 in Bronchoalveolar Lavage of Patients with IPF and NSIP.

Inflammation 2019 Jan 24. Epub 2019 Jan 24.

Respiratory Diseases and Lung Transplantation Unit, AOUS - Department of Medical, Surgical and Neurological Sciences, University of Siena, Viale Bracci, 16 -, 53100, Siena, Italy.

Idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) are the most frequent idiopathic interstitial pneumonias. The aim of this study was to evaluate concentrations of calgranulin B and Krebs von den Lungen 6 (KL-6) in bronchoalveolar lavage (BAL) fluid of patients with IPF and idiopathic NSIP (i-NSIP) with fibrotic pattern. Thirty patients with IPF (68. Read More

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http://link.springer.com/10.1007/s10753-018-00955-2
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http://dx.doi.org/10.1007/s10753-018-00955-2DOI Listing
January 2019
5 Reads

Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats.

Inflammation 2019 Jan 24. Epub 2019 Jan 24.

Department of Anesthesiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No.160 Pudian Road, Shanghai, China.

Cardiopulmonary bypass (CPB) can induce inflammatory lung injury, which is a common complication during cardiac surgery. Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in lung injury after CPB. Previous studies have shown that electroacupuncture (EA) has potential anti-inflammatory activity. Read More

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http://dx.doi.org/10.1007/s10753-018-0944-yDOI Listing
January 2019
1 Read
1.921 Impact Factor

Honokiol Attenuates Sepsis-Associated Acute Kidney Injury via the Inhibition of Oxidative Stress and Inflammation.

Inflammation 2019 Jan 24. Epub 2019 Jan 24.

Intensive Care Unit, the First Affiliated Hospital of Dalian Medical University, No.222 Zhongshan Road, Dalian, 116011, Liaoning, China.

Acute kidney injury (AKI) is one of the most common complications of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural polyphenol from the traditional Chinese herb Magnolia officinalis, is known to possess anti-inflammatory and antioxidant activity. Here, the underlying mechanism of honokiol-induced amelioration of sepsis-associated AKI was analyzed. Read More

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http://dx.doi.org/10.1007/s10753-018-0937-xDOI Listing
January 2019

Review: the Roles and Mechanisms of Glycoprotein 130 Cytokines in the Regulation of Adipocyte Biological Function.

Inflammation 2019 Jan 19. Epub 2019 Jan 19.

Cardiology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Chronic low-grade inflammation is now widely accepted as one of the most important contributors to metabolic disorders. Glycoprotein 130 (gp130) cytokines are involved in the regulation of metabolic activity. Studies have shown that several gp130 cytokines, such as interleukin-6 (IL-6), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), have divergent effects on adipogenesis, lipolysis, and insulin sensitivity as well as food intake. Read More

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http://dx.doi.org/10.1007/s10753-019-00959-6DOI Listing
January 2019

Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-κB Signaling.

Inflammation 2019 Jan 15. Epub 2019 Jan 15.

Iintensive Care Unit, Heze Municipal Hospital, No. 2888, West Caozhou Road, Heze, 274031, China.

This study investigated the protective effect and underlying mechanism of action of umbelliferone (Umb) against lipopolysaccharide (LPS)-induced acute lung injury (ALI). An intragastric Umb injection prior to the administration of LPS dramatically decreased the wet/dry lung weight ratio, attenuated inflammatory cell infiltration in lung tissue, and reduced the LPS-induced production of inflammatory cytokines, including monocyte chemotactic protein-1(MCP-1), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), and IL-1β, in broncheoalveolar lavage fluid (BALF). In addition, Umb resulted in significant anti-oxidative effects as shown by decreased myeloperoxidase (MPO) and malondialdehyde (MDA) activity and increased superoxide dismutase (SOD) activity compared with the LPS group. Read More

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http://link.springer.com/10.1007/s10753-018-00953-4
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http://dx.doi.org/10.1007/s10753-018-00953-4DOI Listing
January 2019
3 Reads

Autophagy Activation Improves Lung Injury and Inflammation in Sepsis.

Inflammation 2019 Jan 15. Epub 2019 Jan 15.

Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, 300052, People's Republic of China.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) undergoes the process of pathological event including lung tissue dysfunction, pulmonary edema, and inflammation in sepsis. Autophagy is a cytoprotective process recognized as one of the major pathways for degradation and recycling of cellular constituents. Autophagy as a protective or maladaptive response was still confused in ALI during sepsis. Read More

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http://dx.doi.org/10.1007/s10753-018-00952-5DOI Listing
January 2019
10 Reads

Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.

Inflammation 2019 Jan 7. Epub 2019 Jan 7.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

It has been reported that matrix metalloproteinases (MMPs) are induced by many cytokines, and they are involved in various inflammatory processes, including periodontitis. However, the effects of interleukin-1β (IL-1β) on MMP-9 expression in cementoblasts, the cells responsible for cementum production, remain largely unknown. In this study, we used qPCR and gelatin zymogram analysis to show that IL-1β upregulated MMP-9 expression in cementoblast-derived cell line. Read More

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http://dx.doi.org/10.1007/s10753-018-00951-6DOI Listing
January 2019
1 Read
1.921 Impact Factor

B Cells Increase Myocardial Inflammation by Suppressing M2 Macrophage Polarization in Coxsackie Virus B3-Induced Acute Myocarditis.

Inflammation 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, People's Republic of China.

The role of B cells in viral myocarditis (VMC) remains controversial. In order to establish a role and mechanism of action for B cells in acute VMC, we established an acute VMC mouse model by intraperitoneal injection of Coxsackie virus group B type 3 (CVB3). At day 7, mice were analyzed using myocardial histopathology, and the presence of M2 macrophages in spleen and heart. Read More

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http://dx.doi.org/10.1007/s10753-018-0950-0DOI Listing
January 2019
2 Reads

Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative.

Inflammation 2018 Dec 19. Epub 2018 Dec 19.

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.

The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim of this study was to investigate the anti-arthritic effects of JC3 in rat models of carrageenan-induced paw pain and carrageenan/kaolin-induced knee arthritis. The anti-nociceptive effect of JC3 was assessed by measuring paw withdrawal pressure thresholds using an analgesy-meter. Read More

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http://link.springer.com/10.1007/s10753-018-0947-8
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http://dx.doi.org/10.1007/s10753-018-0947-8DOI Listing
December 2018
1 Read

Cannabinoid CB Receptor Antagonist Rimonabant Decreases Levels of Markers of Organ Dysfunction and Alters Vascular Reactivity in Aortic Vessels in Late Sepsis in Rats.

Inflammation 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Curitiba, Paraná, Brazil.

Sepsis is a life-threatening condition with high mortality rates that is caused by dysregulation of the host response to infection. We previously showed that treatment with the cannabinoid CB receptor antagonist rimonabant reduced mortality rates in animals with sepsis that was induced by cecal ligation and puncture (CLP). This improvement in the survival rate appeared to be related to an increase in arginine vasopressin (AVP) levels 12 h after CLP. Read More

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http://dx.doi.org/10.1007/s10753-018-0919-zDOI Listing
December 2018
1 Read

Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome.

Inflammation 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, Zhejiang Hospital, 12 Lingyin Road, Zhejiang, Hangzhou, China.

The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. Read More

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http://dx.doi.org/10.1007/s10753-018-0945-xDOI Listing
December 2018
1 Read

Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice.

Inflammation 2018 Dec 15. Epub 2018 Dec 15.

College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.

Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Read More

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http://dx.doi.org/10.1007/s10753-018-0948-7DOI Listing
December 2018
1 Read

The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Inflammation 2018 Dec 14. Epub 2018 Dec 14.

Postgraduate Program of Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.

Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. Read More

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http://dx.doi.org/10.1007/s10753-018-0946-9DOI Listing
December 2018
1.921 Impact Factor

Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation.

Inflammation 2018 Dec 12. Epub 2018 Dec 12.

Department of Neonatology, Guangdong Women and Children Hospital, Guang Zhou Medical University, Guangzhou, 510010, Guangdong, China.

Intrauterine inflammation is the main reason for neonatal adverse outcomes and normal placenta perfusion plays an important role in fetal development. However, whether inflammation will affect placental angiogenesis and the underlying mechanism are still poorly understood. To investigate lipopolysaccharide (LPS)-induced intrauterine inflammation on placenta angiogenesis and Wnt5a-Flt1 expression. Read More

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http://dx.doi.org/10.1007/s10753-018-0936-yDOI Listing
December 2018

Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA + DHA.

Inflammation 2018 Dec 10. Epub 2018 Dec 10.

Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, 570020, India.

Effect of aging and hyperglycemia on oxidative stress (OS) and inflammation in dyslipidemic conditions has not been elucidated. Hence, in this study, we assessed the implications of aging, hyperglycemia, and also the dietary effect of n-3 fatty acids (α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)) on OS and inflammation in dyslipidemic rats. Dyslipidemia was induced in young and aged rats by feeding high-fat lard (HFL) diet. Read More

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http://link.springer.com/10.1007/s10753-018-0949-6
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http://dx.doi.org/10.1007/s10753-018-0949-6DOI Listing
December 2018
5 Reads
1.921 Impact Factor

Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway.

Inflammation 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Affiliated Hospital of Southwest Medical University, No. 25, Tai Ping Street, Jiangyang District, 646000, Luzhou, China.

Schisandrin B (SchB) is an active compound extracted from the Chinese herb Schisandra chinensis and shows excellent anti-inflammatory activity. This study was performed to examine the effects of SchB in a rat model of IgA nephropathy (IgAN). IgAN was established in Sprague-Dawley rats by immunization with lipopolysaccharide (LPS), bovine serum albumin, and carbon tetrachloride. Read More

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http://dx.doi.org/10.1007/s10753-018-0943-zDOI Listing
December 2018
4 Reads

Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.

Inflammation 2018 Dec 3. Epub 2018 Dec 3.

Department of Periodontics and Oral Biology, School of Stomatology, China Medical University, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.

Porphyromonas gingivalis (P. gingivalis) is an important pathogen that contributes to periodontal disease and causes infections that promote the progression of atherosclerosis. Our previous studies showed that macrophage migration inhibitory factor (MIF) facilitates monocyte adhesion to endothelial cells by regulating the expression of intercellular adhesion molecule-1 (ICAM-1) in P. Read More

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http://dx.doi.org/10.1007/s10753-018-0942-0DOI Listing
December 2018
2 Reads

Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees.

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

Department of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, Kurose-Gakuendai 555-36, Higashi-Hiroshima, Hiroshima, 739-2695, Japan.

We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3 weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W + L) groups. Read More

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http://dx.doi.org/10.1007/s10753-018-0941-1DOI Listing
December 2018
1 Read

Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4.

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

Department of Emergency, People's Hospital of Ningxia Hui Autonomous Region, the First Affiliated Hospital of Northwest University for Nationalities, No.301 Zhengyuan North Street, Yinchuan, 750000, Ningxia, China.

To investigate the mechanism of Schisandrin B (Sch B) on the inflammation in LPS-induced sepsis. Sepsis mouse model was established by injecting LPS. qRT-PCR and western blot were used to measure the expression of miR-17-5p and TLR4. Read More

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http://dx.doi.org/10.1007/s10753-018-0931-3DOI Listing
December 2018
1 Read
1.921 Impact Factor

DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway.

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

School of Stomatology, Dalian Medical University, Dalian, 116044, People's Republic of China.

Macrophages play a fundamental role in human chronic diseases such as rheumatoid arthritis, atherosclerosis, and cancer. In the present study, we demonstrated that dual-specificity phosphatase 6 (DUSP6) was upregulated by lipopolysaccharide (LPS) treatment of macrophages. (E/Z)-BCI hydrochloride (BCI) functions as a small molecule inhibitor of DUSP6, and BCI treatment inhibited DUSP6 expression in LPS-activated macrophages. Read More

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http://dx.doi.org/10.1007/s10753-018-0924-2DOI Listing
December 2018
2 Reads

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting.

Authors:
Vijay Kumar

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

Children's Health Queensland Clinical Unit, Department of Paediatrics and Child Care, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, QLD, 4078, Australia.

Sepsis is a major health problem all over the world. Despite its existence since the time of Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units. The most current US FDA-approved drug called recombinant human activated protein C or Drotrecogin-α is also failed in clinical trials and showed similar effects as placebo. Read More

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http://dx.doi.org/10.1007/s10753-018-0939-8DOI Listing
December 2018
1 Read
1.921 Impact Factor

Insulin Antagonizes LPS-Induced Inflammatory Responses by Activating SR-A1/ERK Axis in Macrophages.

Inflammation 2018 Nov 29. Epub 2018 Nov 29.

Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, No. 101, Longmian Road, Nanjing, 211166, Jiangsu, People's Republic of China.

Insulin is a key regulator of metabolism and inflammation in the body. However, the mechanism of the anti-inflammatory effect of insulin is not fully understood. In the present study, we investigated the role of the class A1 scavenger receptor (SR-A1), a prototypic member of the pattern recognition receptor family, in the insulin-mediated suppression of inflammatory responses in macrophages. Read More

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http://dx.doi.org/10.1007/s10753-018-0933-1DOI Listing
November 2018
2 Reads
1.921 Impact Factor

Peroxisome Proliferator-Activated Receptor γ Agonist Rosiglitazone Protects Blood-Brain Barrier Integrity Following Diffuse Axonal Injury by Decreasing the Levels of Inflammatory Mediators Through a Caveolin-1-Dependent Pathway.

Inflammation 2018 Nov 28. Epub 2018 Nov 28.

Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, 710004, People's Republic of China.

Our early experiments confirmed that rosiglitazone (RSG), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, had therapeutic potential for the treatment of diffuse axonal injury (DAI) by inhibiting the expression of amyloid-beta precursor protein and reducing the loss and abnormal phosphorylation of tau, but the underlying mechanisms were not fully defined. In this study, we aimed to investigate a possible role for PPARγ in the protection of blood-brain barrier (BBB) integrity in a rat model of DAI, and the underlying mechanisms. PPAR agonists and antagonists were intraperitoneally injected after DAI. Read More

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http://link.springer.com/10.1007/s10753-018-0940-2
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http://dx.doi.org/10.1007/s10753-018-0940-2DOI Listing
November 2018
1 Read

Degradation Products of Polydopamine Restrained Inflammatory Response of LPS-Stimulated Macrophages Through Mediation TLR-4-MYD88 Dependent Signaling Pathways by Antioxidant.

Inflammation 2018 Nov 27. Epub 2018 Nov 27.

Division of Immunology, Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Polydopamine (PDA) has a promising application as coating of biomaterials due to its favorable degradability and bioadaptability. However, its bioactivity, such as anti-inflammatory capacity, was still little known. Herein, we investigated whether degradable products of PDA could affect inflammatory response in lipopolysaccharide (LPS)-stimulated human THP-1-derived macrophages. Read More

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http://dx.doi.org/10.1007/s10753-018-0923-3DOI Listing
November 2018
1 Read
1.921 Impact Factor

Interleukin (IL)-35 Suppresses IL-6 and IL-8 Production in IL-17A-Stimulated Human Periodontal Ligament Cells.

Inflammation 2018 Nov 27. Epub 2018 Nov 27.

Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.

Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 is reported to suppress IL-17A-producing helper T (Th17) cell activation. IL-17A is related to progression of periodontitis. Read More

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http://dx.doi.org/10.1007/s10753-018-0938-9DOI Listing
November 2018

Metabolomics Analysis Reveals Therapeutic Effects of α-Mangostin on Collagen-Induced Arthritis in Rats by Down-regulating Nicotinamide Phosphoribosyltransferase.

Inflammation 2018 Nov 27. Epub 2018 Nov 27.

Yijishan Hospital of Wannan Medical College, 2 West Zheshan Road, Wuhu, 241000, China.

α-Mangostin (MAN) is a bioactive compound isolated from pericarp of mangosteen (Garcinia mangostana Linn.) with significant anti-rheumatic potentials. The purpose of this study was to explore the mechanisms underlying its therapeutic effects on collagen-induced arthritis (CIA) in rats with metabolomics approaches. Read More

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http://dx.doi.org/10.1007/s10753-018-0932-2DOI Listing
November 2018
1 Read

The Expression of CXCL10/CXCR3 and Effect of the Axis on the Function of T Lymphocyte Involved in Oral Lichen Planus.

Inflammation 2018 Nov 22. Epub 2018 Nov 22.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.

The etiology of oral lichen planus (OLP) is still not clear. The purpose of this study was to explore the role of CXC chemokine receptor 3(CXCR3) and its ligand CXC motif chemokine 10(CXCL10) in the pathogenesis of OLP. We examined the expression of CXCR3 and CXCL10 in OLP patients and healthy controls by quantitative real-time PCR, Western blotting, ELISAs, and immunohistochemistry, respectively. Read More

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http://dx.doi.org/10.1007/s10753-018-0934-0DOI Listing
November 2018
3 Reads

Effects of Human Interleukin-10 on Ventilator-Associated Lung Injury in Rats.

Inflammation 2018 Nov 22. Epub 2018 Nov 22.

Department of Anesthesiology, the First Hospital of Fujian Medical University, Fuzhou, 350005, China.

Ventilator-induced lung injury (VILI) is one of the most serious complications of mechanical ventilation (MV) and can increase the mortality of patients with acute respiratory distress syndrome (ARDS). This work aimed to test the hypothesis that the anti-inflammatory properties of human interleukin-10 (hIL-10) can reduce VILI. Thirty-six healthy male Sprague-Dawley rats were randomly assigned into three groups (n = 12) as follows: a control group, a VILI group, and a hIL-10 group. Read More

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http://dx.doi.org/10.1007/s10753-018-0911-7DOI Listing
November 2018
11 Reads

Neutrophil Cytosolic Factor 1 Contributes to the Development of Sepsis.

Inflammation 2018 Nov 21. Epub 2018 Nov 21.

The Intravenous Drug Centralization Division of Jinan Central Hospital, Jinan Central Hospital, Jinan, 250014, Shandong, China.

To identify differentially expressed genes in sepsis and potential key role of reactive oxygen species (ROS) genes associated with sepsis. Gene expression dataset was available from GSE46599. Firstly, we screened the differentially expressed genes between sepsis and healthy samples. Read More

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http://link.springer.com/10.1007/s10753-018-0935-z
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http://dx.doi.org/10.1007/s10753-018-0935-zDOI Listing
November 2018
12 Reads

Breast Implant Texturization Does Not Affect the Crosstalk Between MSC and ALCL Cells.

Inflammation 2018 Nov 16. Epub 2018 Nov 16.

Department of Clinical and Molecular Sciences- Histology, Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy.

In the last decade, there has been a growing interest about the possible association between anaplastic large cell lymphoma (ALCL) and breast implants (BIA-ALCL). Many variables, such as breast implants texturization, have been investigated. Breast implants often lead to the formation of a periprosthetic capsule, characterized by inflammation. Read More

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http://link.springer.com/10.1007/s10753-018-0930-4
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http://dx.doi.org/10.1007/s10753-018-0930-4DOI Listing
November 2018
5 Reads

1,25-Dihydroxy Vitamin D Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM via the p38/NF-κB/NLRP3 Pathway.

Inflammation 2018 Nov 14. Epub 2018 Nov 14.

School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, China.

Vitamin D is reported to be involved in the regulation of inflammatory processes. In this study, biomarkers related to oxidative stress and inflammation were investigated to clarify the protective effects and possible mechanism of 1,25-dihydroxy vitamin D (1,25-(OH)D) on PM-induced inflammatory response. In the in vitro study using human bronchial epithelial (HBE) cells, aqueous extracts of PM could induce oxidative damage which is characterized by significant increases in production of reactive oxygen species, malonaldehyde concentration, and protein expression of HSPA1A and HO-1. Read More

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http://dx.doi.org/10.1007/s10753-018-0928-yDOI Listing
November 2018
2 Reads
1.921 Impact Factor

Correction to: Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-κB/P65 Pathway in Rheumatoid Arthritis.

Inflammation 2018 Nov 10. Epub 2018 Nov 10.

Department of Orthopedics, Affiliated Hospital of Nantong University, No.20 Xisi Road, Nantong City, Jiangsu, 226001, China.

Unfortunately the author name, Rongqing Qin, was wrongly spelt as Rongqin Qin in the original version. It has been updated and the complete corrected author group is given below. Read More

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http://dx.doi.org/10.1007/s10753-018-0925-1DOI Listing
November 2018