89,485 results match your criteria Infertility
Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.
Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More
Chem Biol Interact 2018 Dec 3. Epub 2018 Dec 3.
Department of Occupational and Environmental Health, School of Public Health, Shandong University, China. Electronic address:
Understanding of the mechanism of embryo loss is critical for successful pregnancy considering an increase in the incidence of infertility. In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS). CS is a material used in certain production processes, and women are sometimes exposed to it in occupational settings. Read More
PLoS One 2018 6;13(12):e0208485. Epub 2018 Dec 6.
Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide, and an important health problem especially in women of reproductive age. This study aimed to determine the relationship between IDA and sexual satisfaction and function among reproductive-aged Iranian women. In this study, 129 women (52 with IDA and 77 non-IDA) with age 18-45 in Mahshahr, Iran were recruited. Read More
PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.
Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.
Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More
Reproduction 2018 Dec 1. Epub 2018 Dec 1.
L Salamonsen, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia.
The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity. I have contributed to understanding the molecular and cellular changes underpinning these events, and how disturbance of them leads to menstrual disorders, infertility and endometrial diseases including abnormal uterine bleeding, endometriosis and endometrial cancer. Read More
Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.
Department of Urology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Introduction: Endometriosis consists in the proliferation of endometrial tissue outside of the uterine cavity, predominantly in the ovaries but also in the urinary bladder or bowel. About 10% of fertile women are affected and the main symptoms are pain, menstrual disorders and infertility. Surgery is the treatment option for those symptomatic patients in which medical treatment had no success. Read More
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
National Health and Medical Research Council Centre for Research Excellence in PCOS, Monash University, Melbourne, Victoria, Australia.
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.
Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?
Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.
What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More
Am J Physiol Renal Physiol 2018 Dec 6. Epub 2018 Dec 6.
Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, United States.
Zinc (Zn) is the second most abundant trace element, but is considered a micronutrient as it is a cofactor for many enzymes and transcription factors. While Zn deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn is nephrotoxic. As for other ions and solutes, Zn is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Gynecology, Linyi People's Hospital, Linyi, China.
Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More
Prenat Diagn 2018 Dec 5. Epub 2018 Dec 5.
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ.
Advanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut-offs, which has complicated systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Read More
Cardiovasc Intervent Radiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
Introduction: Varicocele is often associated with impaired sperm parameters. Different procedures have been developed for varicocele treatment. The aim of this study was to evaluate the effects of varicocele treatment on conventional sperm parameters. Read More
Mol Cell Proteomics 2018 Dec 5. Epub 2018 Dec 5.
Molecular Biology of Reproduction and Development, Human Genetics Unit, Faculty of Medicine, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, and Hospital Clinic, Spain
Our aim was to define seminal plasma proteome signatures of infertile patients categorized according to their seminal parameters using TMT-LC-MS/MS. To that extent, quantitative proteomic data was analyzed following two complementary strategies: (i) the conventional approach based on standard statistical analyses of relative protein quantification values; and (ii) a novel strategy focused on establishing stable-protein pairs. By conventional analyses, the abundance of some seminal plasma proteins was found to be positively correlated with sperm concentration. Read More
Reprod Biomed Online 2018 Nov 13. Epub 2018 Nov 13.
AP-HP, Reproductive Biology Unit, Paris-Sud University, Paris-Saclay University, Antoine Béclère Hospital, Clamart 92140, France.
Research Question: Chromosomal translocations are known genetic causes of male infertility. Are certain translocations or chromosomal regions more directly associated with sperm defects? Is there a threshold of sperm impairment that can be relevant for detection of translocations?
Design: This is a monocentric retrospective observational study covering a 10-year period. Eighty-one patients carrying a reciprocal translocation (RCT) and 63 carrying a Robertsonian translocation (ROBT) were compared with 105 fertile patients. Read More
Best Pract Res Clin Obstet Gynaecol 2018 Nov 6;53:20-29. Epub 2018 Oct 6.
Department of Obstetrics and Gynaecology, University of Amsterdam, Amsterdam, the Netherlands.
Unexplained infertility is defined as the absence of conception despite 12 months of unprotected intercourse, not explained by anovulation, poor sperm quality, tubal pathology or any known cause of infertility. The two most applied treatments for unexplained infertility are intra-uterine insemination and in vitro fertilisation. As these treatments do not target a specific mechanism but rather increase the probability of conception as compared to natural conception chances, they should be weighed against the prognosis of natural conception. Read More
BMC Womens Health 2018 Dec 5;18(1):197. Epub 2018 Dec 5.
Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.
Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More
Cell J 2019 Apr 18;21(1):49-56. Epub 2018 Nov 18.
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic
Objective: Fast Free-of-Acrylamide Clearing Tissue (FACT) is a recently developed protocol for the whole tissue three-dimensional (3D) imaging. The FACT protocol clears lipids using sodium dodecyl sulfate (SDS) to increase the penetration of light and reflection of fluorescent signals from the depth of cleared tissue. The aim of the present study was using FACT protocol in combination with imaging of auto-fluorescency of red blood cells in vessels to image the vasculature of a translucent mouse tissues. Read More
Cell J 2019 Jan 18;21(1):35-42. Epub 2018 Nov 18.
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Objective: The extracellular matrix (ECM) of the cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore gene expression profiles for ECM and cell adhesion molecules in the cumulus cells of polycystic ovary syndrome (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS).
Materials And Methods: In this prospective case-control study enrolled 23 women less than 36 years of age who participated in an intracytoplasmic sperm injection (ICSI) program. Read More
J Zhejiang Univ Sci B 2018 Dec.;19(12):948-959
Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Stress affects the male reproductive system and can cause sub-fertility or infertility. Although Phyllanthus emblica L. (PE) extract has been shown to have high antioxidant capacity and protective properties in damaged tissue, the preventive effects of PE extract on testicular function from stress-related impairment have never been demonstrated. Read More
J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.
Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
Dioxins (eg, 2,3,7,8-tetrachlorodibenzo-p-dioxin/TCDD), as environmental endocrine disruptors and toxic carcinogens, can affect male reproductive health. The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR). In this study, we investigated the association of AhRR-c. Read More
Mol Biol Rep 2018 Dec 1. Epub 2018 Dec 1.
Department of Microbiology, Immunology and Biochemistry, University of Tennessee, Health Science Center, Memphis, TN, USA.
Rheumatoid arthritis (RA) is considered as a long-term autoimmune disorder. Gene polymorphism and oxidative stress might be involved in the pathogenesis of the disease. We aimed to determine the association between PON-1L55M polymorphism and its effects on inflammatory markers such as anti-cytroline circulated-peptide (CCP)-antibodies, C-reactive protein (CRP), neopterin serum concentration, arylesterase (ARE) and butyrylcholinesterase (BuChE) activities and total-antioxidant-capacity (TAC) level with the activity of disease in RA patients. Read More
Int Urogynecol J 2018 Dec 1. Epub 2018 Dec 1.
Department of Gynecology and Obstetrics, Imam Khomeini Hospital, Fellowship in Pelvic Floor Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Introduction And Hypothesis: Most patients suffering from vaginismus feel sinful, anxious, and incompetent, with reduced self-confidence. This study was aimed at comparing the effectiveness of the physiotherapy of pelvic floor muscles as a standard treatment and local injection of botulinum toxin on the sexual functioning of patients with primary vaginismus.
Methods: In this randomized clinical trial (RCT), the study population included women with primary vaginismus referred to the Sexual Health and Gynecologic Clinics of Imam Khomeini Hospital during 2013-2014. Read More
Transl Androl Urol 2018 Dec;7(6):941-949
Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.
Spina bifida is a congenital neural tube defect with many neurological implications, as well as decreased sexual function and infertility. Few studies have directly investigated infertility in men with spina bifida. Infertility in this special patient population is primarily the result of spermatogenic defects and/or failure of sperm transport due to erectile or ejaculatory dysfunction. Read More
Transl Androl Urol 2018 Dec;7(6):920-925
Smith Institute for Urology, Northwell Health, New Hyde Park, NY, USA.
Background: The prevalence of varicoceles is estimated to be 15% in the general population but is nearly 35% among men with primary infertility and increases by 10% with each decade of life. Studies among adults infer a higher rate of varicoceles among first-degree relatives of patients with varicoceles. However, these studies do not consider the presence of varicoceles, or other venous abnormalities, at the time of desired paternity in first-degree relatives of adolescent patients. Read More
J Pak Med Assoc 2018 Dec;68(12):1769-1781
The Department of Gynecology, Shandong University of Traditional Chinese Medicine, Jinan, China.
Objective: To assess the difference in the metabolomics profiles of follicular fluid between older and younger reproductive-aged women.
Methods: The retrospective study was conducted at the Centre of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China and comprised patient data related to the period between July and October 2015. Follicular fluid was obtained from male-factor infertility women aged 28-35 years as the younger group A, and those aged 35-42 years as the older group B. Read More
Best Pract Res Clin Endocrinol Metab 2018 Nov 3. Epub 2018 Nov 3.
Department of Obstetrics and Gynecology, Hôpital Foch - Université de Paris Ouest (UVSQ), France.
Endometriosis - a disease causing pain and infertility - is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and ART. Surgery enhances the chances of conceiving naturally during the 12-18 ensuing months irrespective of the stage of the disease. Read More
Fertil Steril 2018 Dec;110(7):1410-1411
Department of Urology, University of Miami, Miami, Florida. Electronic address:
Objective: To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser.
Design: Video presentation.
Setting: University hospital. Read More
Fertil Steril 2018 Dec;110(7):1347-1355
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut; Innovation Fertility Preservation and IVF, New York, New York. Electronic address:
Objective: To evaluate the impact of cancer diagnosis on response to ovarian stimulation for fertility preservation.
Setting: Not applicable. Read More
Fertil Steril 2018 Dec;110(7):1328-1337
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Objective: To evaluate the relationship between demographic, lifestyle, and reproductive factors and the risk of ectopic pregnancy (EP).
Design: Prospective cohort.
Setting: United States. Read More
Fertil Steril 2018 Dec;110(7):1298-1310
Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.
Objective: To study the effect of aging and granulosa cell growth hormone receptor (GHR) expression, and the effect of growth hormone (GH) co-treatment during IVF on receptor expression.
Design: Laboratory study.
Setting: University. Read More
Fertil Steril 2018 Dec;110(7):1285-1289
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, New York.
Objective: To assess the impact of using donor sperm in assisted reproductive technology (ART) cycles on perinatal outcomes.
Design: Historical cohort study.
Setting: US national database from the Society of Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 2012 to 2013. Read More
Fertil Steril 2018 Dec;110(7):1275-1276
Department of Surgery, McGill University Health Center, McGill University, Montreal, Quebec, Canada.
Fertil Steril 2018 Dec;110(7):1272-1273
Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois.
Fertil Steril 2018 Dec;110(7):1261-1262
Reproductive Partners San Diego and Division of Reproductive Endocrinology and Infertility, University of California, San Diego, California.
Fertil Steril 2018 Dec;110(7):1218-1226
Société de Recherche pour l'Infertilité (SRI), Brussels, Belgium.
Fertil Steril 2018 Dec;110(7):1216-1217
Société de Recherche pour l'Infertilité, Brussels, Belgium.
Fertil Steril 2018 Dec;110(7):1203-1208
Bioethics Institute Ghent, Department of Philosophy and Moral Sciences, Ghent University, Ghent, Belgium.
Two major breakthroughs in the field of assisted reproduction-oocyte donation and oocyte vitrification-have joined forces to create the rapidly emerging phenomenon of commercial egg banks (CEBs). In this review, we examine the history of this concept, the operational models, the geographical variations, and the benefits and pitfalls of CEBs, including the ethical and legal dilemmas arising from gamete mobility. We highlight future directions in the brave new world of third-party reproduction. Read More
J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.
Institute of Maternal and Child Research, School of Medicine, University of Chile.
Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).
Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.
Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More
J Theor Biol 2018 Nov 28. Epub 2018 Nov 28.
IVIRMA, Madrid. Av del Talgo, Madrid, 68. 28023, Spain; IdiPaz, Calle de Pedro Rico, Madrid, 6. 28029, Spain; Rey Juan Carlos University, Madrid, Spain. Electronic address:
The aim of this work is to study the aging rate at which human follicles reach the preovulatory state. To this end, both telomere length and telomerase activity effects on granulosa cells (GCs) aging has been studied. GCs are somatic cells which determine the development of the oocyte. Read More
Reprod Biomed Online 2018 Nov 16. Epub 2018 Nov 16.
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 173A Goessmann, 686 North Pleasant Street, Amherst MA 01003, USA.. Electronic address:
Research Question: To examine associations between sperm mitochondrial DNA copy number (mtDNAcn), sperm mitochondrial DNA deletions (mtDNAdel), semen parameters and clinical infertility in an IVF setting.
Design: A total of 125 sperm samples were collected from men undergoing assisted reproductive procedures in an IVF clinic in Western Massachusetts, USA. Sperm mtDNAcn and mtDNAdel were measured by probe-based quantitative polymerase chain reaction. Read More
Reprod Biol Endocrinol 2018 Dec 2;16(1):113. Epub 2018 Dec 2.
Center of Reproductive Medicine and Surgery, Arcispedale Santa Maria Nuova (ASMN) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy.
There is growing evidence that lifestyle choices account for the overall quality of health and life (QoL) reflecting many potential lifestyle risks widely associated with alterations of the reproductive function up to the infertility. This review aims to summarize in a critical fashion the current knowledge about the potential effects of stress and QoL on female reproductive function. A specific literature search up to August 2017 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar. Read More
Leuk Lymphoma 2018 Dec 3:1-10. Epub 2018 Dec 3.
a The Shraga Segal Dept. of Microbiology, Immunology, and Genetics , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
Spermatogenesis is the process of the proliferation and differentiation of spermatogonial stem cells (SSCs) to generate sperm. Leukemia patients show impairment in some of the endocrine hormones that are involved in spermatogenesis. They also show a decrease in semen parameters before and after thawing of cryopreserved samples compared to a control. Read More
Int J Mol Sci 2018 Nov 29;19(12). Epub 2018 Nov 29.
The Shraga Segal Department of Microbiology, Immunology, and Genetics, Beer-Sheva 84105, Israel.
Aggressive chemotherapy may lead to permanent male infertility. Prepubertal males do not generate sperm, but their testes do contain spermatogonial cells (SPGCs) that could be used for fertility preservation. In the present study, we examined the effect of busulfan (BU) on the SPGCs of immature mice, and the possible induction of the survivor SPGCs to develop spermatogenesis in 3D in-vitro culture. Read More
Urol Int 2018 Dec 5:1-14. Epub 2018 Dec 5.
Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries.
Materials And Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Read More
Reprod Fertil Dev 2018 Dec 6. Epub 2018 Dec 6.
A strain of Staphylococcus aureus, capable of in vitro immobilisation of human and mouse spermatozoa, was already present in our laboratory. Therefore, in the present study, the factor responsible (sperm immobilisation factor, SIF) was isolated and purified. It was found to compromise not only motility, but also viability, morphology and Mg2+-ATPase activity of mouse spermatozoa. Read More
J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population.
Design: Women with PCOS-like status ("PCOSp") were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index and high levels of anti-müllerian hormone. Read More
Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.
Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
Study Question: Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality in white European men seeking medical help for primary couple's infertility?
Summary Answer: HPV seminal infections involving high-risk (HR) genotypes are associated with impaired sperm progressive motility and sperm DNA fragmentation (SDF) values.
What Is Known Already: HPV is commonly present in semen samples. However, whether the presence of HPV in semen is actually associated with impaired sperm parameters and SDF values have yet to be elucidated. Read More
Hum Reprod 2018 Dec 5. Epub 2018 Dec 5.
University Paris Descartes, Sorbonne Paris Cité, Faculty of Medicine, Assistance Publique-Hôpitaux de Paris, University Hospital Paris Centre, CHU Cochin, Laboratory of Histology Embryology Biology of Reproduction, 123 boulevard de Port Royal, Paris, France.
Study Question: Is JUNO protein present at the surface membrane of human oocytes and involved in the fertilisation process?
Summary Answer: JUNO protein is expressed on the plasma membrane of human oocytes and its inhibition by a monoclonal antibody completely blocks gamete fusion.
What Is Known Already: Fusion of gamete membranes is the culminating event of the fertilisation process, but its molecular mechanisms are poorly understood. Until now, three molecules have been shown to be essential: CD9 tetraspanin in the oocyte, Izumo1 protein on the sperm and Juno, its corresponding receptor on the oocyte. Read More
Endocrinology 2018 Dec 4. Epub 2018 Dec 4.
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School.
The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive development and function. Activation of specific, high affinity cell surface receptors (GnRHR) on gonadotropes by GnRH triggers signal transduction cascades to stimulate the coordinated synthesis and secretion of the pituitary gonadotropins, FSH and LH. These hormones direct gonadal steroidogenesis and gametogenesis, making their tightly regulated production and secretion essential for normal sexual maturation and reproductive health. Read More
Hum Mol Genet 2018 Dec 5. Epub 2018 Dec 5.
INSERM, Institut Cochin, Paris, France.