90,473 results match your criteria Infertility


High-throughput transcriptome-Seq and small RNA-Seq reveal novel functional genes and microRNAs for early embryonic arrest in humans.

Gene 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, China. Electronic address:

Early Embryonic Arrest (EEA) is one of the major causes of female infertility. Genetic factors including specific genes and miRNAs may play pivotal roles on EEA. However, it is not well defined what genes and micro RNAs participate the pathophysiological alterations of EEA. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.084DOI Listing
February 2019

Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):719-722

Department of Obstetrics and Gynecology, Infertility Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques.

Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject.

Materials And Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled. Read More

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November 2018

Cyclophosphamide-induced testicular toxicity ameliorate by treatment: An experimental study.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):711-718

Solid Tumor Research Center Urmia . University of Medical Sciences, Urmia, Iran.

Background: Cyclophosphamide (CP) is one of the most invasive chemotherapeutic agents, which used commonly despite of its wide spectrum toxicity. Clinical evidence showed toxic side effects of CP in multiple organ systems.

Objective: The objective of the present study was to evaluate the effects of on CP-induced testicular toxicity in rats. Read More

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November 2018

The effect of inflammatory diseases associated with opportunistic urogenital infection on the hormonal function of the female reproductive system.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):697-702

Dermatovenerology Department, Kazan State Medical University, Kazan, Russia.

Background: Sexually transmitted infections play a great role in formation of inflammatory diseases of female urogenital system. These diseases can cause a decrease in the level of female sex hormones, as well as the ratio of estrogens and androgens.

Objective: To determine changes in the state of sex hormones in women with inflammatory diseases of ovaries associated with opportunistic urogenital flora. Read More

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November 2018

Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):689-696

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Vitamin D has multifaceted function in human reproductive physiology. It has been revealed that vitamin D is involved in spermatogenesis, and semen quality can be linked to vitamin D status in men.

Objective: Evaluating the correlation of 25-hydroxy vitamin D (25-OHD) levels in serum with basic and advanced semen parameters and essential determinants of spermatozoa function. Read More

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November 2018

The prevalence of infertility in 20-49 years women in Yazd, 2014-2015: A cross-sectional study.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):683-688

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Infertility is a serious health problem that affects the individual, her/his family, and the community. Infertility is defined as failure to achieve clinical pregnancy after at least 12 months of unprotected coitus.

Objective: The purpose of this study was to investigate the prevalence of primary and secondary infertility and the associated factors in Yazd Greater Area during 2014-2015. Read More

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November 2018

Acute and sub-acute toxicity of aqueous extract of aerial parts of N. E. Brown in mice and rats.

Heliyon 2019 Jan 29;5(1):e01179. Epub 2019 Jan 29.

Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences College of Health Sciences, University of Ilorin, Kwara State, Nigeria.

N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356088PMC
January 2019

Evaluation of polymorphism of protein codon 72 in oral lichen planus by PCR technique.

J Dent Res Dent Clin Dent Prospects 2018 19;12(4):245-251. Epub 2018 Dec 19.

Department of Genetics, Research and Clinical Center for Infertility, Shahid Sadoughi Medical Sciences University, Yazd, Iran.

Our research was aimed to study protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Seventy paraffin-embedded tissue samples (30 OLP, 20 OSCC and 20 IFH) were studied. DNA was purified and amplified using allele-specific polymerase chain reaction to detect polymorphism. Read More

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http://dx.doi.org/10.15171/joddd.2018.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368942PMC
December 2018

Protein intake and the risk of premenstrual syndrome.

Public Health Nutr 2019 Feb 18:1-8. Epub 2019 Feb 18.

1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.

Objective: To examine the relationship between protein intake and the risk of incident premenstrual syndrome (PMS).

Design: Nested case-control study. FFQ were completed every 4 years during follow-up. Read More

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http://dx.doi.org/10.1017/S1368980018004019DOI Listing
February 2019

Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review.

J Pediatr Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Electronic address:

Background/purpose: The purpose of this systematic review by the American Pediatric Surgical Cancer Committee was to summarize evidence from the current medical literature regarding fertility restoration and hormone replacement for female children and adolescents treated with gonadotoxic treatments.

Methods: Using PRISMA guidelines, questions were addressed by searching Medline, Cochrane, Embase Central and National clearing house databases using relevant search terms. Eligible studies included those that addressed ovarian tissue cryopreservation (OTC), oocyte harvest, ovarian transposition, and ovarian tissue auto-transplantation for females under the age of 20. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.021DOI Listing
January 2019

Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation.

Reprod Biomed Online 2018 Dec 22. Epub 2018 Dec 22.

Department of Obstetrics and Gynecology, Keio University Graduate School of Medicine, 35 Shinanomachi, -Shinjyuku-ku, Tokyo 160-8582, Japan.

Research Question: Do gut microbiota associate with the ovulatory cycle in women showing normogonadotrophic anovulation? In humans, the gut microbiota affects diverse physiological functions and dysbiosis (microbial imbalance) may lead to pathological syndromes. However, there is comparatively little information on the relevance of gut microbiota to reproductive functions in women. Here, a group of women with idiopathic chronic anovulation were examined, who do not exhibit any apparent endocrinological disorder, as they are suitable for investigating the relationship between intestinal bacteria and ovulatory disorders. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.026DOI Listing
December 2018

A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI, 49503, USA. Electronic address:

The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.034DOI Listing
February 2019

Age at menarche and clinical outcomes following medically assisted reproduction (MAR): a cohort study.

Gynecol Endocrinol 2019 Feb 18:1-5. Epub 2019 Feb 18.

a Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology , "Attikon Hospital ", Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Medically assisted reproduction (MAR) technologies have advanced rapidly, but in contrast to the specificity of modern approaches, they provide limited effectiveness in the management of the infertile couple. The purpose of this study was to assess the possible relationship between age at menarche and MAR outcomes of clinical pregnancy, live birth and the adverse incident of miscarriage, and to determine the offspring sex ratio according to age at menarche. In a cohort of 254 infertile couples who underwent 426 IVF/ICSI cycles, statistical analysis was performed by applying Student's t-test, chi-square test, and logistic regression models, adequately in the respective parameters and outcomes. Read More

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http://dx.doi.org/10.1080/09513590.2018.1538344DOI Listing
February 2019

The effect of maternal body mass index (BMI) and telomere function on in vitro fertilization (IVF) outcome: a preliminary cohort study.

Hum Fertil (Camb) 2019 Feb 17:1-7. Epub 2019 Feb 17.

b Sackler School of Medicine , Tel Aviv University , Tel Aviv , Israel.

Telomeres are a specific base sequence of DNA, responsible for chromosome stability and DNA protection. We aimed to investigate the association between telomere systems and IVF outcomes according to patients' BMI. For all telomere characteristics, there was a distinct trend towards shorter telomeres and activation of telomere shortening compensatory mechanisms in the BMI group >25kg/m, reaching statistical significance for senescence only (r = 0. Read More

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http://dx.doi.org/10.1080/14647273.2019.1575988DOI Listing
February 2019

miR-21 reverses impaired decidualization through modulation of KLF12 and NR4A1 expression in human endometrial stromal cells†.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that micro RNAs (miR) play a crucial role in embryo implantation. Read More

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http://dx.doi.org/10.1093/biolre/ioz026DOI Listing
February 2019

Utilization and outcomes of fertility preservation techniques in women undergoing allogeneic hematopoietic cell transplant.

Biol Blood Marrow Transplant 2019 Feb 14. Epub 2019 Feb 14.

Division of Hematology, Mayo Clinic, Rochester MN. Electronic address:

Iatrogenic menopause with consequent infertility is a major complication in reproductive aged women undergoing hematopoietic cell transplantation (HCT). Recent guidelines recommend a discussion of the possibility of infertility and the options for fertility preservation as part of informed consent before initiation of any cancer-directed therapy, including HCT. Women aged 15-49 years at the time of allogeneic HCT, between the years 2001 and 2017, were identified from the Mayo Clinic Rochester institutional HCT database. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.013DOI Listing
February 2019

Pelvic Peritoneal Pockets: Distribution, Histopathology, and Clinical Significance.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

The Fertility Clinic, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Schulich School of Medicine and Dentistry, Western University, London, ON.

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http://dx.doi.org/10.1016/j.jogc.2018.05.016DOI Listing
February 2019

Poches Péritonéales Pelviennes: Distribution, Histopathologie et Signification Clinique.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

The Fertility Clinic, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Schulich School of Medicine and Dentistry, Western University, London, ON.

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http://dx.doi.org/10.1016/j.jogc.2018.12.009DOI Listing
February 2019

Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve.

EBioMedicine 2019 Feb 13. Epub 2019 Feb 13.

Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu 611130, PR China. Electronic address:

Background: Global consumption of protein per capita is rising, while rates of infertility are increasing. However, a clear relationship between protein intake and reproductive health has not been demonstrated. The activation of the quiescent primordial follicles is the first step of folliculogenesis, and their activation must be tightly controlled to prevent premature exhaustion of the ovarian follicular reserve. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.020DOI Listing
February 2019

Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men.

Reprod Biol Endocrinol 2019 Feb 16;17(1):24. Epub 2019 Feb 16.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, ACECR, Royan Institute for Biotechnology, Isfahan, Iran.

Background: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation with N-acetyl-cysteine (NAC) on the sperm quality, chromatin integrity and levels of oxidative stress in infertile men. Read More

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http://dx.doi.org/10.1186/s12958-019-0468-9DOI Listing
February 2019

SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy; Infertility Service, San Salvatore Hospital, L'Aquila 67100, L'Aquila, Italy. Electronic address:

Methylglyoxal (MG), a highly reactive dicarbonyl derived from metabolic processes, is the most powerful precursor of advanced glycation end products (AGEs). Glycative stress has been recently associated with ovarian dysfunctions in aging and PCOS syndrome. We have investigated the role of the NAD-dependent Class III deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.011DOI Listing
February 2019

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

Nat Commun 2019 Feb 15;10(1):777. Epub 2019 Feb 15.

Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland.

Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar). Read More

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http://dx.doi.org/10.1038/s41467-019-08730-zDOI Listing
February 2019

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion.

Stem Cell Res Ther 2019 Feb 15;10(1):61. Epub 2019 Feb 15.

Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Reproductive Medicine Center, Obstetrics and Gynecology Department, Shengjing Hospital affiliated to China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning, China.

Background: Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregnancy and endometrium regeneration. We also initiated platelet-rich plasma (PRP) acted as a beneficial supplement in MenSC culturing and a potential endometrial receptivity regulator. Read More

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http://dx.doi.org/10.1186/s13287-019-1155-7DOI Listing
February 2019

Resilience acts as a moderator in the relationship between infertility-related stress and fertility quality of life among women with infertility: a cross-sectional study.

Health Qual Life Outcomes 2019 Feb 15;17(1):38. Epub 2019 Feb 15.

Department of Social Medicine, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Background: Infertility-related stress can seriously impact the fertility quality of life (QoL) of infertile women. Resilience, as a coping resource, can effectively combat psychological stress. This study aimed to evaluate the fertility QoL of infertile women and to examine whether resilience moderates the association of infertility-related stress with fertility QoL. Read More

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http://dx.doi.org/10.1186/s12955-019-1099-8DOI Listing
February 2019

Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019
1 Read

The endometrium during and after ovarian hyperstimulation and the role of segmentation of infertility treatment.

Best Pract Res Clin Endocrinol Metab 2018 Sep 13. Epub 2018 Sep 13.

Department of Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

Controlled ovarian hyperstimulation (COH) is a crucial part of assisted reproductive technologies (ART) that resulted in a substantial increase in pregnancy rates from in vitro fertilization (IVF). However, in spite of the apparent benefit of COH on an increase in the number of follicles and the number of oocytes retrieved, allowing for extended embryo culture and enabling the selection of the best quality embryo for transfer, several reports has shown that the supraphysiologic hormonal levels may indeed have a detrimental effect at the endometrial level. The current article revises the pathophysiological mechanisms through which ovarian stimulation may negatively affect endometrial receptivity. Read More

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http://dx.doi.org/10.1016/j.beem.2018.09.003DOI Listing
September 2018

Current Progress in Uterus Transplantation Research in Asia.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. Read More

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http://dx.doi.org/10.3390/jcm8020245DOI Listing
February 2019
1 Read

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
February 2019

Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism.

Aging Male 2019 Feb 15:1-10. Epub 2019 Feb 15.

b Laboratory of Physiology and Biochemistry of Exercise Faculty of Human Kinetics , Universidade de Lisboa , Cruz Quebrada , Portugal.

Hypogonadism affects an extensive part of the male population, especially among the elderly. The quest for treatment regarding low levels of serum testosterone and male infertility has, therefore, worldwide relevance. Zinc has important biological actions insofar as the male reproductive physiology and endocrine system. Read More

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http://dx.doi.org/10.1080/13685538.2019.1573220DOI Listing
February 2019

Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.

Expert Rev Endocrinol Metab 2019 Jan 31:1-13. Epub 2019 Jan 31.

a Department of Obstetrics and Gynecology , University of Wisconsin , Madison , WI , USA.

Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial and highly prevalent endocrine disorder, progress towards a cure is hindered by absence of a definitive pathogenic mechanism and lack of an animal model of naturally occurring PCOS. Areas covered: These include an overview of PCOS and its potential etiology, and an examination of insights gained into its pathogenic origins. Read More

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http://dx.doi.org/10.1080/17446651.2019.1576522DOI Listing
January 2019

Predictors of breastfeeding non-initiation in the NICU.

Matern Child Nutr 2019 Feb 14:e12797. Epub 2019 Feb 14.

OB/GYN Department, University of Cincinnati, Cincinnati, OH, USA.

This study compared predictors of breastfeeding non-initiation between infants who were and were not admitted to the NICU so that interventions can target high-risk mothers whose infants desperately need breastmilk. This was a population-based retrospective cohort study of singleton Ohio live births using birth certificates, 2006-2015. In babies who were and were not admitted to the NICU, a multivariable logistic regression model assessed the association between breastfeeding non-initiation and predictors relating to the mother, neonate, and labor and delivery events while adjusting for covariables. Read More

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http://dx.doi.org/10.1111/mcn.12797DOI Listing
February 2019

The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review.

Andrology 2019 Feb 15. Epub 2019 Feb 15.

Department of Urology, University of Washington Medical Center, Seattle, WA, USA.

Background: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Read More

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http://dx.doi.org/10.1111/andr.12585DOI Listing
February 2019

Effect of Chemotherapeutics and Tocopherols on MCF-7 Breast Adenocarcinoma and KGN Ovarian Carcinoma Cell Lines .

Biomed Res Int 2019 15;2019:6146972. Epub 2019 Jan 15.

Department of Medical Biotechnology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5052, Australia.

The combination of doxorubicin and cyclophosphamide commonly used to treat breast cancer can cause premature ovarian failure and infertility. -Tocopherol is a potent antioxidant whereas -tocopherol causes apoptosis in a variety of cancer models including breast cancer. We hypothesised that the combination of doxorubicin (Dox) and 4-hydroperoxycyclophosphamide (4-Cyc) would be more cytotoxic than each agent alone, and that -tocopherol would reduce and -tocopherol would augment the cytotoxicity of the combined chemotherapeutics. Read More

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http://dx.doi.org/10.1155/2019/6146972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350544PMC
January 2019

Uterine artery embolization in the treatment of symptomatic fibroids - state of the art 2018.

Authors:
Anna Stępniak

Prz Menopauzalny 2018 Dec 31;17(4):141-143. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Uterine fibroids are considered to be the most common benign tumours in females. The vast majority of these tumours are incidental findings and do not require any treatment. Symptomatic fibroids, with ailments such as abnormal uterine bleeding, dysmenorrhoea, pelvic pain, impaired urination, bowel dysfunction, infertility, and recurrent pregnancy loss, are indicated for medical treatment. Read More

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http://dx.doi.org/10.5114/pm.2018.81733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372851PMC
December 2018

Novel mutations in PATL2: expanding the mutational spectrum and corresponding phenotypic variability associated with female infertility.

J Hum Genet 2019 Feb 14. Epub 2019 Feb 14.

State Key Laboratory of Genetic Engineering, Zhongshan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

Oocyte maturation arrest results in primary female infertility, but the genetic etiology of this phenotype remains largely unknown. Previously, we and other groups have reported that biallelic mutations in PATL2 are mainly responsible for human oocyte germinal vesicle-stage arrest and that the specific phenotype varies for different mutations. Here, we identified four novel missense mutations (p. Read More

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http://dx.doi.org/10.1038/s10038-019-0568-6DOI Listing
February 2019

Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin.

Pathophysiology 2019 Feb 5. Epub 2019 Feb 5.

Department of Theriogenology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. Electronic address:

Reproductive dysfunction is a common consequence of both obesity and diabetes. This study investigated the impact of obesity and diabetes, alone or combined, on physiological reproductive parameters in male rats. Twenty-four male Wistar Albino rats were divided into four groups: Control; obese non-diabetic; diabetic; and obese diabetic. Read More

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http://dx.doi.org/10.1016/j.pathophys.2019.02.001DOI Listing
February 2019

Obesity and reduced fertility of men.

Authors:
M Škurla R Rybář

Ceska Gynekol 2018 ;83(3):212-217

Objective: Description of the relationship between the overweight man and the reduction of his reproductive potential.

Design: Review article.

Setting: Center of Assisted Reproduction Sanus, Jihlava. Read More

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January 2018

Robot assisted laparoscopic abdominal cerclage: two case reports.

Ceska Gynekol 2018 ;83(3):195-200

Objective: In this work we report the first use of robot-assisted preconceptual abdominal cerclage in the Czech Republic with subsequent live birth. We present two patients with a history of late pregnancy losses (late miscarriage) who underwent robotic abdominal cerclage.

Design: Case report. Read More

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January 2018

Altered Molecular Pathways in the Proteome of Cryopreserved Sperm in Testicular Cancer Patients before Treatment.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Center of Excellence in Genomic Medicine Research, Jeddah 21589, Saudi Arabia.

Testicular cancer (TC) represents the most common cancer affecting men within the reproductive age and is often accompanied by major disturbances in semen parameters. Cryopreservation is recommended in these patients before initiating cancer treatment. Currently, there are no studies reporting the molecular mechanisms associated with altered semen quality in these men. Read More

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http://dx.doi.org/10.3390/ijms20030677DOI Listing
February 2019
2.862 Impact Factor

F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY 10065. Electronic address:

Objective: The bioavailability of the non-hormonal male contraceptive adjudin is low in rats due to the blood-testis barrier (BTB). This study was designed to examine if F5-peptide, an endogenously produced reversible BTB modifier, could enhance the bioavailability of adjudin to affect spermatogenesis and provide a contraceptive effect in rats while reducing systemic toxicity.

Study Design: We overexpressed F5-peptide in adult male rats (n=10 rats; with 3 or 4 rats for each of the three different experiments noted in the three regimens) by intratesticular injection of a mammalian expression vector pCI-neo (pCI-neo/F5-peptide) vs. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.007DOI Listing
February 2019
2.335 Impact Factor

Waist circumference in relation to outcomes of infertility treatment with assisted reproductive technologies.

Am J Obstet Gynecol 2019 Feb 11. Epub 2019 Feb 11.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Background: Many studies have documented lower likelihood of live birth with increasing body mass index (BMI) among women undergoing assisted reproductive technologies (ART), but few have examined the association with waist circumference (WC), an anthropometric measure that allows assessment of central adiposity.

Objective(s): To examine the relation between baseline WC and infertility treatment outcomes among women undergoing treatment with ART.

Study Design: We followed 264 women who underwent 445 ART cycles for infertility treatment at the Massachusetts General Hospital between 2010 and 2017. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.013DOI Listing
February 2019

Three-dimensional 3D ultrasound combined with power Doppler for the differential diagnosis of endometrial lesions among infertile women.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Reproductive Medicine Center, Luoyang Center Hospital of Zhengzhou University, Luoyang, China.

Objective: To assess three-dimensional (3D) ultrasound combined with power Doppler (PD) for the differential diagnosis of endometrial lesions among infertile women.

Methods: A prospective study carried out at a reproductive medicine center in Luoyang, China, between January and December 2015. The inclusion criteria were asymptomatic infertility with normal endometrium or specific endometrial lesions. Read More

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http://dx.doi.org/10.1002/ijgo.12787DOI Listing
February 2019

Case 29-2018: A 31-Year-Old Woman with Infertility.

Authors:

N Engl J Med 2019 Feb;380(7):697

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http://dx.doi.org/10.1056/NEJMx190004DOI Listing
February 2019

Case 29-2018: A Woman with Infertility.

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N Engl J Med 2019 Feb;380(7):694-695

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http://dx.doi.org/10.1056/NEJMc1900145DOI Listing
February 2019

Effect of hysteroscopy before starting in-vitro fertilization for women with recurrent implantation failure: A meta-analysis and systematic review.

Medicine (Baltimore) 2019 Feb;98(7):e14075

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Objective: To study if hysteroscopy (HSC) before starting an in-vitro fertilization (IVF) cycle improves IVF outcomes in women with recurrent implantation failure (RIF).

Methods: The Medline, Cochrane, EMBASE, and Google Scholar databases were searched using the following keywords until March 31, 2017: in-vitro fertilization; infertility; hysteroscopy; recurrence; embryo implantation; and pregnancy. Randomized controlled trials (RCTs), two-arm prospective studies, and retrospective studies were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000014075DOI Listing
February 2019

Transcriptomic profile of cell cycle progression genes in human ovarian granulosa cells.

J Biol Regul Homeost Agents 2019 Feb 14;33(1). Epub 2019 Feb 14.

Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland.

The ovarian granulosa cells (GCs) that form the structure of follicle undergo substantial modification during the various stages of human folliculogenesis. These modifications include morphological changes, accompanied by differential expression of genes, encoding proteins which are mainly involved in cell growth, proliferation and differentiation. Recent data bring a new insight into the aspects of GCs' stem-like specificity and plasticity, enabling their prolonged proliferation and differentiation into other cell types. Read More

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February 2019

Expression of proteins related to thyroid hormone function in the uterus is down-regulated at the day of implantation in hypothyroid pregnant rats.

Cell Biol Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Hypothyroidism has been linked to infertility, but the mechanisms underlying infertility-related hypothyroidism have yet to be fully elucidated. Therefore, in this study, effects of hypothyroidism on expression of the proteins related to thyroid hormone function in the uterus, which were thought to play a role implantation, including thyroid hormone receptor (TR), thyroid stimulating hormone receptor (TSHR), retinoic acid receptor (RAR) and extracellular kinase (ERK) were identified. Pregnant female rats were rendered hypothyroid by giving methimazole (MMI), orally. Read More

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http://dx.doi.org/10.1002/cbin.11114DOI Listing
February 2019

Applying behavioral theory to understand fertility consultation uptake after cancer.

Psychooncology 2019 Feb 14. Epub 2019 Feb 14.

UC San Diego Moores Cancer Center.

Objective: The objective of this study was to examine the association between theoretical constructs from the Health Belief Model and fertility consultation status after cancer.

Methods: Reproductive-aged female cancer survivors self-reported their use of fertility consultation, perceived severity of and susceptibility to infertility, perceived barriers to and effectiveness of fertility consultation, and cues to action from family/peers and doctors, as well as demographics and cancer characteristics. Logistic regression was used to analyze the association between theoretical constructs and fertility consultation status. Read More

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http://dx.doi.org/10.1002/pon.5027DOI Listing
February 2019

History of the Obesogen Field: Looking Back to Look Forward.

Front Endocrinol (Lausanne) 2019 29;10:14. Epub 2019 Jan 29.

Program on Endocrine Disruption Strategies, Commonweal, Bolinas, CA, United States.

The Obesogen field developed from two separate scientific research areas, endocrine disruptors and the Developmental Origins of Health and Disease (DOHaD). Endocrine Disrupting Chemicals (EDCs) are exogenous chemicals or mixtures of chemicals that interfere with the action of hormones. Exposure to EDCs during early development (DOHaD) has been shown to increase susceptibility to a variety of diseases including infertility, asthma, breast and prostate cancer, early puberty, susceptibility to infections, heart disease, autoimmune disease, and attention deficit hyperactivity disorder/learning disability. Read More

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http://dx.doi.org/10.3389/fendo.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362096PMC
January 2019
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Unraveling the Function of Lemur Tyrosine Kinase 2 Network.

Front Pharmacol 2019 29;10:24. Epub 2019 Jan 29.

Department of Nephrology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.

Lemur Tyrosine Kinase 2 (LMTK2) is a recently cloned transmembrane protein, actually a serine/threonine kinase named after the Madagascar primate lemur due to the long intracellular C-terminal tail. LMTK2 is relatively little known, compared to other kinases but its role has been increasingly recognized. Published data show that LMTK2 regulates key cellular events, including endocytic trafficking, nerve growth factor signaling, apoptosis, and Cl transport. Read More

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http://dx.doi.org/10.3389/fphar.2019.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361741PMC
January 2019