96,445 results match your criteria Infertility


Environmental contaminants and male infertility: Effects and mechanisms.

Andrologia 2020 May 24:e13646. Epub 2020 May 24.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth and function of male reproductive organs. Several epidemiological reports have correlated the blood and seminal levels of environmental contaminants with poor sperm quality. Read More

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http://dx.doi.org/10.1111/and.13646DOI Listing

N, N-Dimethylacetamide, an FDA approved excipient, acts post-meiotically to impair spermatogenesis and cause infertility in rats.

Chemosphere 2020 May 15;256:127001. Epub 2020 May 15.

University of Zurich, Center of Dental Medicine, Oral Biotechnology & Bioengineering, Plattenstrasse11, 8032, Zürich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland; CABMM, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zürich, Switzerland. Electronic address:

N, N-Dimethylacetamide is an FDA approved solvent widely used in pharmaceutical industry to facilitate the solubility of lipophilic, high molecular weight drugs with poor water solubility. However, the cytotoxic effects of DMA raises the concern about its use in clinical applications. In the present study, we address the effect of DMA on spermatogenesis. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127001DOI Listing

Biochemistry of infertility.

Clin Chim Acta 2020 May 21. Epub 2020 May 21.

Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland;; Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland. Electronic address:

Infertility affects approximately 186 million people worldwide and 8-12% of couples of reproductive age. Therefore, a comprehensive diagnostic evaluation of infertility is crucial to achieving improvements in targeted prevention and treatment outcomes. The aim of this review is to explore the biochemistry of infertility in order to properly diagnose and treat infertile couples. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.039DOI Listing

CENP-W regulates kinetochore-microtubule attachment and meiotic progression of mouse oocytes.

Biochem Biophys Res Commun 2020 Jun 24;527(1):8-14. Epub 2020 Apr 24.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Oocyte meiotic maturation failure and unfaithful chromosome segregation are major causes for female infertility. Here, we showed that CENP-W, a relatively novel member of the kinetochore protein family, was expressed in mouse oocytes from the germinal vesicle (GV) to metaphase II (MII) stages. Confocal microscopy revealed that CENP-W was localized in the germinal vesicle in the GV stage, and then became concentrated on kinetochores during oocyte maturation. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.078DOI Listing

Decisional Conflict and Knowledge Among Patients with Varicocele Seeking Treatment for Infertility.

Urology 2020 May 20. Epub 2020 May 20.

Department of Urology, David Geffen School of Medicine at University of California, Los Angeles, 10945 Le Conte Ave, Ueberroth #3361, Los Angeles, CA 90095. Electronic address:

Objective: To study disease-specific knowledge and decisional quality in men with varicocele being counseled for infertility.

Methods: A instrument designed to measure decisional quality by evaluating disease-specific knowledge, decisional conflict, and impression that shared decision-making was administered to 92 men identified to have a varicocele seeking their initial infertility consultation. Mean scores on disease-specific knowledge questionnaire, prevalence of decisional conflict, and impact of consultation on preferred infertility treatment were analyzed. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.014DOI Listing

Testicular ultrasound (TU) score: a new proposal for a scoring system to predict testicular function.

Andrology 2020 May 23. Epub 2020 May 23.

Department of Experimental Medicine, Sapienza" University of Rome, Rome, Italy.

Background: Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume is hampered by a lack of information on the prognostic value of its findings, which to date have only been incorporated in a score proposed by Lenz et al. in 1993. Read More

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http://dx.doi.org/10.1111/andr.12822DOI Listing

Gonadotropin Treatment For The Male Hypogonadotropic Hypogonadism.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan. Italy.

Hypogonadotropic hypogonadism (HH) is caused by a dysfunction in the hypothalamus and/or the pituitary gland and it can be congenital or acquired. This condition is biochemically characterized by low or inappropriately normal gonadotropins levels along with low total testosterone levels. If fertility is not an issue, testosterone therapy is the treatment of choice to induce and maintain secondary sexual characteristics and sexual function. Read More

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http://dx.doi.org/10.2174/1381612826666200523175806DOI Listing

An update on stem cell therapy for Asherman syndrome.

J Assist Reprod Genet 2020 May 22. Epub 2020 May 22.

Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

The current treatment for Asherman syndrome is limited and not very effective. The aim of this review is to summarize the most recent evidence for stem cells in the treatment of Asherman syndrome. The advent of stem cell therapy has propagated experimentation on mice and humans as a novel treatment. Read More

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http://dx.doi.org/10.1007/s10815-020-01801-xDOI Listing

Evaluation and treatment of infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy.

Reprod Biomed Online 2020 Apr 28. Epub 2020 Apr 28.

Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, Catania 95123, Italy. Electronic address:

Asherman syndrome is a rare acquired clinical condition resulting in the obliteration of the uterine cavity causedby the presence of partial or complete fibrous intrauterine adhesions involving at least two-thirds of the uterine cavity potentially obstructing the internal cervical orifice. Common reported symptoms of the disease are alterations of the menstrual pattern with decreased menstrual bleeding leading up to amenorrhoea and infertility. Hysteroscopy is currently considered the gold standard diagnostic and therapeutic approach for patients with intrauterine adhesions. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.03.021DOI Listing

Sperm proteomic changes associated with early embryo quality after ICSI.

Reprod Biomed Online 2020 May 11;40(5):700-710. Epub 2020 Jan 11.

EUGIN-UB Research Excellence Program; Molecular Biology of Reproduction and Development Research Group, Fundació Clínic per a la Recerca Biomèdica (FCRB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Casanova 143, Barcelona 08036, Spain; Biochemistry and Molecular Genetics Service, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain. Electronic address:

Research Question: Do alterations of human sperm protein profile affect embryo quality?

Design: Sperm proteins from 27 infertile couples undergoing intracytoplasmic sperm injection (ICSI) were extracted and digested. The resulting peptides were labelled using tandem mass tags, separated by two-dimensional liquid chromatography, and identified and quantified using tandem mass spectrometry. Subsequently, sperm protein and peptide abundance were statistically analysed for correlation with ICSI-derived embryo quality in the subset of idiopathic infertile couples. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.01.004DOI Listing

Effects of a short-term mindfulness-based stress reduction program on the quality of life of women with infertility: A randomized controlled clinical trial.

Complement Ther Med 2020 May 13;50:102403. Epub 2020 Apr 13.

Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background And Purpose: Although some programs based on mindfulness-based stress reduction (MBSR) have been suggested to promote quality of life (QoL) in different conditions, limited studies have addressed their potential effects in women with infertility. In this study, we aimed to determine the effects of an MBSR program on the QoL of women with infertility.

Materials And Methods: This randomized controlled clinical trial was conducted on 36 women with infertility, who were selected by consecutive sampling from the Infertility Center of Ahvaz Imam Khomeini Hospital, Iran. Read More

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http://dx.doi.org/10.1016/j.ctim.2020.102403DOI Listing

Deep Learning-Based Morphological Classification of Human Sperm Heads.

Diagnostics (Basel) 2020 May 20;10(5). Epub 2020 May 20.

Department of Information and Computational Sciences, School of Mathematical Sciences and LMAM, Peking University, Beijing 100871, China.

Human infertility is considered as a serious disease of the reproductive system that affects more than 10% of couples across the globe and over 30% of the reported cases are related to men. The crucial step in the assessment of male infertility and subfertility is semen analysis that strongly depends on the sperm head morphology, i.e. Read More

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http://dx.doi.org/10.3390/diagnostics10050325DOI Listing

Vitamin D-Binding Protein in Pregnancy and Reproductive Health.

Nutrients 2020 May 20;12(5). Epub 2020 May 20.

Monash Centre for Health Research and Implementation (MCHRI) and Centre of Cardiovascular Research and Education in Therapeutics (CCRET), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168 VIC, Australia.

Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Read More

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http://dx.doi.org/10.3390/nu12051489DOI Listing

Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report.

Medicine (Baltimore) 2020 May;99(20):e20199

Reproductive and Genetic Center of Integrated Traditional and Western Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province.

Introduction: Resistance ovary syndrome (ROS) is a disease characterized by hypergonadotropic amenorrhea but with normal ovarian reserve. Currently, its pathogenesis is still unclear and the treatment methods are complex. Nevertheless, there are evident negative effects of this disease on females' physical and mental health such as gonadal dysplasia, infertility, anxiety, and depression. Read More

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http://dx.doi.org/10.1097/MD.0000000000020199DOI Listing

Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists.

J Clin Endocrinol Metab 2020 May 22. Epub 2020 May 22.

Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, Piazzale Golgi, Pavia, Italy.

Context: Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese women show poorer reproductive outcomes regardless of the mode of conception, and higher body mass index (BMI) is associated with poorer fertility prognosis. Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, and many women with PCOS are also overweight or obese. Read More

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http://dx.doi.org/10.1210/clinem/dgaa285DOI Listing

MRI in the evaluation of the azoospermic male.

Diagn Interv Radiol 2020 May 22. Epub 2020 May 22.

Departments of Radiology and Urology, Medical University of Gdańsk, Gdańsk, Poland.

Purpose: We aimed to show the usefulness of magnetic resonance imaging (MRI) in the evaluation of infertile men and its ability to distinguish obstructive from nonobstructive azoospermia.

Methods: Between April 2015 and February 2018, 45 azoospermic men underwent scrotal MRI. We evaluated the images with an emphasis on signal characteristics of the testis and morphologic changes typical for obstruction. Read More

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http://dx.doi.org/10.5152/dir.2019.19189DOI Listing

Re-determination of upper reference range of follicular stimulating hormone in infertile men.

Syst Biol Reprod Med 2020 May 22:1-8. Epub 2020 May 22.

Department of Urology, Erciyes University , Kayseri, Turkey.

FSH in infertile patients may be measured in the normal range and abnormal semen analysis findings may be observed in patients with normal FSH values. A recent study predicts that the sperm morphology and concentration may be impaired if the FSH value is above 4.5 IU/L. Read More

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http://dx.doi.org/10.1080/19396368.2020.1758834DOI Listing

The possible role of NF-κB1 Rs28362491 polymorphism in male fertility of Egyptian population.

Andrologia 2020 May 22:e13659. Epub 2020 May 22.

Department of Biochemistry & Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Male reproductive impairment is responsible for at least 50% of cases of couple infertility. Nuclear factor-kappa B (NF-κB) has been functionally linked to germ cell apoptosis, which may affect human fertility. The aim of this study was to determine the association between the rs28362491 SNP of the NF-κB1 gene and infertility in Egyptian men. Read More

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http://dx.doi.org/10.1111/and.13659DOI Listing

Reproductive outcomes with donor sperm in couples with severe male-factor infertility after intracytoplasmic sperm injection failures.

J Assist Reprod Genet 2020 May 21. Epub 2020 May 21.

Assisted Reproduction Center, Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University, 73#, Houzaimen North Street, Xi'an, People's Republic of China.

Purpose: To evaluate reproductive outcomes of artificial insemination and IVF with donor sperm (AID or IVF-D) for male-factor couples with a history of unsuccessful ICSI attempt.

Methods: This retrospective cohort includes couples with severe male-factor infertility who failed ICSI treatment, and subsequently underwent semen donation treatment. We report the following outcomes: (1) live birth rates in AID and IVF-D treatment for couples with severe male infertility factors and prior ICSI failures; (2) paternal impact on embryo development of the same oocyte cohort; (3) prognostic factors in obtaining a live birth with donor semen. Read More

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http://dx.doi.org/10.1007/s10815-020-01828-0DOI Listing

Chlorpyrifos effects on integrin alpha v and beta 3 in implantation window phase.

Environ Sci Pollut Res Int 2020 May 22. Epub 2020 May 22.

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran.

Chlorpyrifos (CPF), as a worldwide pesticide, can effect on the integrins αv and β3 which play a main role in the implantation window. Therefore, the aim of this study was to consider CPF effects on integrin alpha v and beta 3 in implantation window phase. Thirty female NMRI mice were separated into groups of CPF, sham, and control. Read More

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http://dx.doi.org/10.1007/s11356-020-08288-0DOI Listing

Polycystic Ovary Syndrome and Pelvic Floor Dysfunction: A Narrative Review.

Res Rep Urol 2020 7;12:179-185. Epub 2020 May 7.

Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pelvic floor dysfunction is one of the most common disorders in women that is associated with social and economic consequences. In general, this disorder imposes direct and indirect costs on the economy of various societies. This review aimed to investigate pelvic floor dysfunction in women with polycystic ovary syndrome (PCOS). Read More

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http://dx.doi.org/10.2147/RRU.S249611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213900PMC

Dissimilar effects of curcumin on human granulosa cells: beyond its anti-oxidative role.

Reprod Toxicol 2020 May 18. Epub 2020 May 18.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, Porto, Portugal.

Global infertility prevalence has been increasing in recent decades, mainly due to advanced reproductive age. Concerned women look for dietary supplements with antioxidant properties advertised as a natural way to increase fertility. Curcumin (CUR) is a polyphenol with antioxidant and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.04.069DOI Listing

Scientific landscape of oxidative stress in male reproductive research: A scientometric study.

Free Radic Biol Med 2020 May 18. Epub 2020 May 18.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA; Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.

Unraveling the role of reactive oxygen species and associated oxidative stress (OS) in male reproduction is one of the key areas of male reproductive research. This article illustrates the scientific landscape of OS in male reproductive research over the past several decades (1941-2018) using a scientometric approach. Scientometric data (articles per year, authors, affiliations, journals, and countries) on OS related to male reproduction were retrieved from the Scopus database and analyzed for each decade. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.008DOI Listing

Effect of supportive counseling on pregnancy-specific stress, general stress, and prenatal health behaviors: A multicenter randomized controlled trial.

Patient Educ Couns 2020 May 5. Epub 2020 May 5.

Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Objective: The aim of this study was to investigate the effects of group supportive counseling (SC) on pregnancy-specific stress, general stress, and healthy behavior of pregnant women.

Methods: This randomized controlled trial study was conducted on 80 pregnant women in two groups; SC for six sessions, once a week for two hours (n = 40), and antenatal usual care (AUC) (n = 40). All Participants completed questionnaires measuring pregnancy-specific stress, state anxiety, prenatal health behaviors, perceived stress, and provided a saliva sample for measurement of cortisol at pre-intervention and 6-week post-intervention. Read More

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http://dx.doi.org/10.1016/j.pec.2020.04.024DOI Listing

Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility.

Int J Mol Sci 2020 May 19;21(10). Epub 2020 May 19.

Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Ovarian follicle steroidogenesis associated with embryo quality results in a successful pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete several steroid and peptide hormones. Follicles harvested from women who conceived after assisted reproductive therapy (ART) had significantly higher estradiol levels in follicular fluids than the follicles from women who failed to conceive after ART. Read More

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http://dx.doi.org/10.3390/ijms21103592DOI Listing

Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition.

Nutrients 2020 May 19;12(5). Epub 2020 May 19.

Unit of Andrology and Reproductive Medicine & Centre for Male Gamete Cryopreservation, Department of Medicine, University of Padova, 35128 Padova, Italy.

Dietary supplements (DS) represent a possible approach to improve sperm parameters and male fertility. A wide range of DS containing different nutrients is now available. Although many authors demonstrated benefits from some nutrients in the improvement of sperm parameters, their real effectiveness is still under debate. Read More

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http://dx.doi.org/10.3390/nu12051472DOI Listing

Orlistat attenuates obesity-induced decline in steroidogenesis and spermatogenesis by up-regulating steroidogenic genes.

Andrology 2020 May 21. Epub 2020 May 21.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: Steroidogenesis decline is reported to be one of the mechanisms associated with obesity-induced male factor subfertility/infertility.

Objectives: We explored the possible preventive/therapeutic effects of orlistat (a medication prescribed for weight loss) on obesity-induced steroidogenesis and spermatogenesis decline.

Methods: Twenty-four adult male Sprague-Dawley rats weighing 250-300 g were randomized into four groups (n = 6/group), namely; normal control (NC), high-fat diet (HFD), HFD plus orlistat preventive (HFD+Opr) group and HFD plus orlistat treatment (HFD+Ot) group. Read More

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http://dx.doi.org/10.1111/andr.12824DOI Listing

Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2.

Mol Ther Nucleic Acids 2020 May 1;20:788-800. Epub 2020 May 1.

Hunan Normal University School of Medicine, 371 Tongzipo Road, Changsha, Hunan 410013, China; The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan 410013, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China. Electronic address:

Spermatogenesis depends on precise epigenetic and genetic regulation of spermatogonial stem cells (SSCs). However, it remains largely unknown about the roles and mechanisms of small noncoding RNA in regulating the self-renewal and apoptosis of human SSCs. Notably, we have found that Homo sapiens-microRNA (hsa-miR)-1908-3p is expressed at a higher level in human spermatogonia than pachytene spermatocytes. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.04.016DOI Listing

Classification algorithm of patients with endometriosis: Proposal for tailored management.

Adv Clin Exp Med 2020 May 21. Epub 2020 May 21.

Gynecology and Obstetrics, Department of Surgical Sciences, City of Health and Science, University of Torino, Italy.

Endometriosis is a pseudoneoplastic disease that has a significant personal and social impact. Unlike other neoplastic diseases, its management is burdened by uncertainty and controversy. The aim of this article is to furnish clinicians with a simple, useful and updated tool to select an appropriate diagnostic-therapeutic care pathway for affected women. Read More

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http://dx.doi.org/10.17219/acem/118849DOI Listing

Chronic Prostatitis/Chronic Pelvic Pain Syndrome patients show Th1 and Th17 self-reactive immune responses specific to prostate and seminal antigens and decreased semen quality.

BJU Int 2020 May 21. Epub 2020 May 21.

Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Objectives: To assess the presence of self-reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Subjects And Methods: peripheral blood and semen samples were collected from CP/CPPS patients and age-matched healthy control volunteers. The analysis of lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) to different seminal plasma-derived and purified PAg, serum autoantibodies specific to PAg, leukocyte subpopulations and inflammatory cytokines in semen, sperm apoptosis/necrosis, and semen quality parameters were performed. Read More

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http://dx.doi.org/10.1111/bju.15117DOI Listing

The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates.

Asian J Androl 2020 May 19. Epub 2020 May 19.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA.

This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and morphology. The mean conventional and intracytoplasmic sperm injection (ICSI) fertilization rates were calculated in each group. Read More

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http://dx.doi.org/10.4103/aja.aja_18_20DOI Listing

Could COVID-19 have an impact on male fertility?

Andrologia 2020 May 21:e13654. Epub 2020 May 21.

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.

The pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to several hypotheses of functional alteration of different organs. The direct influence of this virus on the male urogenital organs is still to be evaluated. However some hypotheses can already be made, especially in the andrological field, for the biological similarity of the SARS-CoV and SARS-CoV2. Read More

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http://dx.doi.org/10.1111/and.13654DOI Listing

Patient demographics and management challenges in an Irish symptomatic breast cancer unit.

Ir J Med Sci 2020 May 20. Epub 2020 May 20.

Department of Medical Oncology, Beaumont Hospital, Dublin, Ireland.

Background: Breast cancer is the most common cancer in women. Beaumont Hospital is a nationally designated symptomatic breast cancer unit, independent of the national screening programme, BreastCheck.

Aims: We hypothesised that patients attending symptomatic breast cancer units differ from national registry data and aimed to characterise this in a retrospective study. Read More

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http://dx.doi.org/10.1007/s11845-020-02245-zDOI Listing

Is intracytoplasmic sperm (ICSI) better than traditional in vitro fertilization (IVF): confirmation of higher blastocyst rates per oocyte using a split insemination design.

J Assist Reprod Genet 2020 May 20. Epub 2020 May 20.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women & Infants Hospital, 90 plain street, Providence, RI, 02905, USA.

Purpose: To explore the effects of traditional vs. intracytoplasmic sperm injection (ICSI) insemination method on the outcome of high-quality blastocyst development in a split sibling oocyte cohort.

Methods: In this retrospective cohort study, we analyzed 62 ICSI/IVF split cycles. Read More

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http://dx.doi.org/10.1007/s10815-020-01819-1DOI Listing

KIR and HLA-C genes in male infertility.

J Assist Reprod Genet 2020 May 20. Epub 2020 May 20.

Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.

Purpose: Approximately 50% of men reporting to clinics for assisted reproduction have abnormal sperm parameters; we therefore considered whether they differ from fertile males in terms of the frequency of KIR and HLA-C genes, suggesting the involvement of NK cells and some T cells in the inflammatory reaction that can occur in the testes, vas deferens, or epididymis.

Method: We tested a total of 1064 men: 445 of them were patients who, together with their female partners, participated in in vitro fertilization (IVF), 298 men whose female partners suffered from recurrent spontaneous abortion. Three hundred twenty-one fertile men constituted the control group. Read More

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http://dx.doi.org/10.1007/s10815-020-01814-6DOI Listing

Phthalate Exposure and Long-Term Epigenomic Consequences: A Review.

Front Genet 2020 6;11:405. Epub 2020 May 6.

Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States.

Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability and plasticity. Phthalates are not present in plastics by covalent bonds and thus can easily leach into the environment and enter the human body by dermal absorption, ingestion, or inhalation. Read More

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http://dx.doi.org/10.3389/fgene.2020.00405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218126PMC

Living as an infertile woman: the case of southern and northern Ghana.

Reprod Health 2020 May 20;17(1):69. Epub 2020 May 20.

Department of Social Science, University of Eastern Finland, Kuopio, Finland.

Background: Infertility is detrimental to the health of married couples, especially women. Despite the consequences associated with the condition, little is done to reduce the repercussions. This study throws more light on the lived experiences of infertile women and on how they can be helped to improve their own condition. Read More

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http://dx.doi.org/10.1186/s12978-020-00920-zDOI Listing

41,XX * male mice: An animal model for Klinefelter syndrome.

Am J Med Genet C Semin Med Genet 2020 May 20. Epub 2020 May 20.

Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Münster, Münster, Germany.

Klinefelter syndrome (KS, 47,XXY) is the most frequent male chromosomal aneuploidy resulting in a highly heterogeneous clinical phenotype associated with hormonal dysbalance, increased rate of co-morbidities, and reduced lifespan. Two hallmarks of KS-affecting testicular functions are consistently observed: Hypergonadotropic hypogonadism and germ cell (GC) loss resulting in infertility. Although KS is being studied for decades, the underlying mechanisms for the observed pathophysiology are still unclear. Read More

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http://dx.doi.org/10.1002/ajmg.c.31796DOI Listing

Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial.

Hum Reprod 2020 May 20. Epub 2020 May 20.

Department of Biostatistics, Yale University School of Public Health, New Haven, CT 06520, USA.

Study Question: Are intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related to live birth rate in couples with unexplained infertility?

Summary Answer: Patient discomfort with IUI and lower inseminate TMC were associated with a reduced live birth rate, while time from hCG injection to IUI, sperm preparation method and ultrasound guidance for IUI were not associated with live birth success.

What Is Already Known: We previously determined that some baseline characteristics of couples with unexplained infertility, including female age, duration of infertility, history of prior loss and income, were related to live birth rate across a course of ovarian stimulation and IUI treatment. However, the relationship between treatment outcomes and per-cycle characteristics, including ultrasound guidance for IUI, timing of IUI relative to hCG injection, difficult or painful IUI and inseminate TMC, are controversial, and most prior investigations have not evaluated live birth outcome. Read More

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http://dx.doi.org/10.1093/humrep/deaa027DOI Listing

Awareness Regarding Causes of Infertility Among Out-patients at a Tertiary Care Hospital in Karachi, Pakistan.

Cureus 2020 Apr 16;12(4):e7685. Epub 2020 Apr 16.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Introduction:  Infertility is the inability of a couple to achieve pregnancy within 12 months of sexual intercourse without the use of contraceptives. The Pakistani population, belonging to a low-middle income country, has a high prevalence of infertility due to a low knowledge and awareness regarding its causes, and lack of healthcare-seeking behavior for this medical issue. The prevalence of infertility in Pakistan is reported as 22%, with primary infertility accounting for 4% of the total cases. Read More

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http://dx.doi.org/10.7759/cureus.7685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233490PMC

and Human Papillomavirus Infection in Women From Southern Hunan Province in China: A Large Observational Study.

Front Microbiol 2020 5;11:827. Epub 2020 May 5.

Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.

and human papillomavirus (HPV) are the most common pathogens of sexually transmitted infections (STIs), which can increase the risk of cervical cancer and infertility. The purpose of this study was to evaluate the prevalence, genotype and risk factors of and/or HPV infection in women attending the annual physical examination, assistant reproductive treatment and visiting the gynecology clinics from Southern Hunan province in China. Cervical-swab samples were collected from 5006 participants. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214719PMC

Anesthesia During Functional Endoscopic Sinus Surgery for Kartagener's Syndrome: A Case Report and Literature Review.

Int J Gen Med 2020 1;13:157-161. Epub 2020 May 1.

Department of Anesthesiology and Intensive Care, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Introduction: Kartagener's syndrome (KS) is a ciliopathic, autosomal recessive disorder characterized by the triad of situs inversus, chronic sinusitis, and bronchiectasis. The abnormal ciliary structure and function lead to variable clinical manifestations, including dextrocardia, pneumonia, bronchitis, chronic rhinosinusitis, otitis media, reduced fertility in women, and infertility in men. This article reports our experience on general anesthesia with endotracheal intubation during functional endoscopic sinus surgery (FESS) in a patient with KS. Read More

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http://dx.doi.org/10.2147/IJGM.S251060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203035PMC

The Identification of Postovulation Infertility with the Measurement of Early Luteal Phase (Peak Day +3) Progesterone Production.

Authors:
Thomas W Hilgers

Linacre Q 2020 Feb 13;87(1):78-84. Epub 2019 Nov 13.

Saint Paul VI Institute for the Study of Human Reproduction, Omaha, NE, USA.

This study reports on 632 cycles from 105 women who were using the CREIGHTON MODEL Fertility™ System to avoid pregnancy and had either a serious reason to avoid pregnancy or some degree of a lack of confidence. A progesterone level was drawn on the third day after the Peak Day as they were charting, and if the progesterone level was 2.3 ng/mL or greater, then ovulation was determined to have passed. Read More

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http://dx.doi.org/10.1177/0024363919885551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016439PMC
February 2020

Oocyte retrieval outcomes among adolescent transgender males.

J Assist Reprod Genet 2020 May 20. Epub 2020 May 20.

IVF and Infertility Unit, Rabin Medical Center, Petach Tikva, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To compare fertility preservation (FP) outcomes among adolescent transgender males with those of cisgender females.

Methods: This retrospective cohort study included nine adolescent transgender males and 39 adolescent cisgender females who underwent FP between January 2017-April 2019 and September 2013-April 2019, respectively. The transgender males were referred before initiating testosterone, and the cisgender females were referred due to cancer diagnosis before starting anticancer treatment. Read More

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http://dx.doi.org/10.1007/s10815-020-01815-5DOI Listing

Combinational approach of retrospective clinical evidence and transcriptomics highlight AMH superiority to FSH, as successful ICSI outcome predictor.

J Assist Reprod Genet 2020 May 20. Epub 2020 May 20.

Assisted Conception Unit "IAKENTRO", Fragokklisias Str, 15125, Athens, Greece.

Objective: Combination of transcriptomic and retrospective clinical data, to assess anti-Mullerian hormone (AMH) functionality at a cumulus cell level and evaluate AMH potential as a suitable marker for IVF outcomes (oocytes retrieved, number of day 3 embryos, gestation outcomes).

Design: Raw RNA-sequencing data of cumulus cells sourced from younger (n = 10) patient group (group A) (age 29 (1 year of age), baseline FSH 7.4 (0. Read More

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http://dx.doi.org/10.1007/s10815-020-01802-wDOI Listing

Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.

Reprod Sci 2020 May 19. Epub 2020 May 19.

IVI Foundation, Av. Fernando Abril Martorell, 106-TorreA-Plantal, 46026, Valencia, Spain.

Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) are primary factors leading to infertility. However, there is a lack of appropriate animal models of DOR usable for assessing new therapeutic strategies. In this study, we aimed to evaluate whether chemotherapy treatment in mice could reproduce features similar of that observed in women with DOR. Read More

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http://dx.doi.org/10.1007/s43032-020-00191-wDOI Listing

CIB4 is essential for the haploid phase of spermatogenesis in mice†.

Biol Reprod 2020 Apr 25. Epub 2020 Apr 25.

Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

Spermatogenesis is a complex developmental process that involves the proliferation of diploid cells, meiotic division, and haploid differentiation. Many genes are shown to be essential for male fertility using knockout (KO) mice; however, there still remain genes to be analyzed to elucidate their molecular mechanism and their roles in spermatogenesis. Calcium- and integrin-binding protein 1 (CIB1) is a ubiquitously expressed protein that possesses three paralogs: CIB2, CIB3, and CIB4. Read More

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http://dx.doi.org/10.1093/biolre/ioaa059DOI Listing

Ulipristal acetate before in vitro fertilization: efficacy in infertile women with submucous fibroids.

Reprod Biol Endocrinol 2020 May 19;18(1):50. Epub 2020 May 19.

Obstetrics and Gynecology Unit, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Le Scotte" Viale Bracci, 53100, Siena, Italy.

Background: The presence of submucous fibroids strongly impacts on IVF results, therefore, these patients should be considered for surgical or medical treatment. The aim of this study was to assess the role of Ulipristal acetate (UPA), a selective progesterone receptor modulator, in restoring uterine cavity deformation due to submucous fibroids, in infertile patients attempting an IVF treatment. The secondary study outcome was to evaluate the impact of preconception UPA treatment on rate of biochemical pregnancy, ongoing pregnancy, and live birth compared to a control group without fibroids. Read More

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http://dx.doi.org/10.1186/s12958-020-00611-1DOI Listing

HPV Infection Affects Human Sperm Functionality by Inhibition of Aquaporin-8.

Cells 2020 May 17;9(5). Epub 2020 May 17.

Department of Molecular Medicine, Human Physiology Unit, University of Pavia, I-27100 Pavia, Italy.

Human sperm cells express different aquaporins (AQPs), AQP3, 7, 8, 11, which are localized both in the plasma membrane and in intracellular structures. Besides cell volume regulation and end stage of cytoplasm removal during sperm maturation, the role of AQPs extends also to reactive oxygen species (ROS) elimination. Moreover, oxidative stress has been shown to inhibit AQP-mediated HO permeability. Read More

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http://dx.doi.org/10.3390/cells9051241DOI Listing

Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes.

Int J Mol Sci 2020 May 15;21(10). Epub 2020 May 15.

Translational 'Omics and Biomarkers group, KK Research Centre, KK Women's and Children's Hospital, Singapore 229899, Singapore.

Endometriosis is a common inflammatory gynecological disorder which causes pelvic scarring, pain, and infertility, characterized by the implantation of endometrial-like lesions outside the uterus. The peritoneum, ovaries, and deep soft tissues are the commonly involved sites, and endometriotic lesions can be classified into three subphenotypes: superficial peritoneal endometriosis (PE), ovarian endometrioma (OE), and deep infiltrating endometriosis (DIE). In 132 women diagnosed laparoscopically with and without endometriosis ( = 73, 59 respectively), and stratified into PE, OE, and DIE, peritoneal fluids (PF) were characterized for 48 cytokines by using multiplex immunoassays. Read More

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http://dx.doi.org/10.3390/ijms21103515DOI Listing