101,921 results match your criteria Infertility

Fertistat: a potential tool for adolescent sexual health.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Geneva University Hospitals, Department of Woman, Child and Adolescent, Catherine McCarey, Department of Woman, Child and Adolescent, Geneva University Hospitals, 30, boulevard de la Cluse, 1205 Geneva, Switzerland.

The FertiStat (fertility status awareness) tool provides personalized advice on reducing risk factors for infertility and seeking medical advice based on lifestyle and reproductive profile.

Study Objective: The aim of our research was to test the FertiStat tool in younger patients (14-24 years). A secondary objective was to screen for and evaluate knowledge of risk factors impacting fertility. Read More

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Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats.

Life Sci 2021 May 11:119605. Epub 2021 May 11.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus (DM) may lead to testicular infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult male rats by high-fat diet consumption for 12 weeks, accompanied by a single dose streptozotocin injection. Read More

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Novel Biallelic Variations Cause Multiple Morphological Abnormalities of the Sperm Flagella.

DNA Cell Biol 2021 May 14. Epub 2021 May 14.

Department of Ophthalmology, Xiang'an Hospital of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China.

Sperm motility is vital to human reproduction, and malformed sperm flagella can cause male infertility. Individuals with multiple morphological abnormalities of the flagella mostly have absent, short, coiled, bent, and/or irregular-caliber flagella. In this study, a patient with male infertility underwent a physical examination along with his wife. Read More

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Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.

Clin Genet 2021 May 14. Epub 2021 May 14.

Reproductive Medicine Centre, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Non-obstructive azoospermia (NOA) is the most severe form of male infertility, and it is primarily associated with genetic defects. We performed whole-exome sequencing of 236 patients with NOA and identified a homozygous pathogenic variant of autophagy-related 4D cysteine peptidase (ATG4D) in two siblings from a consanguineous family and compound heterozygous pathogenic variants of ATG4D in two sporadic cases. The expression of LC3B, a regulator of autophagic activity, was significantly decreased, and the apoptosis rate of spermatogenic cells in testicular tissues was increased. Read More

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Importance of real-time measurement of sperm head morphology in intracytoplasmic sperm injection.

Zygote 2021 May 14:1-8. Epub 2021 May 14.

Department of Advanced Medical Science, Asahikawa Medical University, Hokkaido078-8510, Japan.

Intracytoplasmic sperm injection (ICSI) is an important technique in male infertility treatment. Currently, sperm selection for ICSI in human assisted reproductive technology (ART) is subjective, based on a visual assessment by the operator. Therefore, it is desirable to develop methods that can objectively provide an accurate assessment of the shape and size of sperm heads that use low-magnification microscopy available in most standard fertility clinics. Read More

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A simultaneous next-generation sequencing approach to the diagnosis of couple infertility.

Minerva Endocrinol (Torino) 2021 May 14. Epub 2021 May 14.

MAGI Euregio, Bolzano, Italy.

Background: Infertility is a disorder of the male and/or female reproductive system, characterized by failure to establish a clinical pregnancy after 12 months of regular unprotected sexual intercourse. On a world basis, about one in six couplesare affected by infertility during their reproductive lifespan. Despite a comprehensive diagnostic work-up, infertility in about 50% of couples remains idiopathic. Read More

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Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines.

World J Mens Health 2021 Apr 21. Epub 2021 Apr 21.

Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India.

Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. Read More

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Standardized Laboratory Procedures, Quality Control and Quality Assurance Are Key Requirements for Accurate Semen Analysis in the Evaluation of Infertile Male.

World J Mens Health 2021 Apr 21. Epub 2021 Apr 21.

American Center for Reproductive Medicine, Cleveland, OH, USA.

Semen analysis is a basic test for evaluating male fertility potential, as it plays an essential role in driving the future management and treatment of infertility in couples. Manual semen analysis includes the evaluation of both macroscopic and microscopic parameters, whereas automated semen analysis is conducted through a computer-aided sperm analysis system and can include additional parameters that are not evaluated by manual analysis. Both quality control (QC) and quality assurance (QA) are important to ensure reproducible results for semen analysis, and represent fundamental checks and balances of all stages (pre-analytical, analytical, and post-analytical) of semen analysis. Read More

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Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review.

World J Mens Health 2021 Apr 16. Epub 2021 Apr 16.

Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Purpose: Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged chromatin and a decreased ability to repair DNA strand breaks. However, the impact of advanced paternal age on DNA fragmentation remains inconclusive. The aim of the present systematic review was to investigate the impact of advancing paternal age (APA) on DNA fragmentation. Read More

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BAG2-Mediated Inhibition of CHIP Expression and Overexpression of MDM2 Contribute to the Initiation of Endometriosis by Modulating Estrogen Receptor Status.

Front Cell Dev Biol 2020 27;8:554190. Epub 2021 Apr 27.

Union Hospital, Tongji Medical College, Institute of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Endometriosis is an estrogen-dependent gynecological disease primarily affecting women of childbearing age, which gives rise to pelvic pain calling for multiple operations, and sometimes leading to infertility. However, the etiology of endometriosis remains poorly understood. In this study we investigated the roles of two Ubiquitin E3 Ligases, namely hsc70-interacting protein (CHIP) and mouse double minute 2 (MDM2), in the abnormal estrogenic activity in endometriosis. Read More

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Procreative rights denied? Access to assisted reproduction technologies by single women in China.

Lei Zhu

J Law Biosci 2021 Jan-Jun;8(1):lsaa084. Epub 2021 Feb 22.

Institute of International Law, Wuhan University, Wuhan City, Hubei Province, China.

The Chinese regulatory framework on access to assisted reproduction technologies (hereafter ART) is relatively restrictive, limiting ART exclusively to heterosexual married couples as a medical treatment for infertility. ART clinics across China are prohibited from providing ART services for single women. This creates significant regulatory barrier for single women to exercise their procreative rights. Read More

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February 2021

The Efficacy of Complementary and Alternative Medicine in the Treatment of Female Infertility.

Evid Based Complement Alternat Med 2021 23;2021:6634309. Epub 2021 Apr 23.

Digestive Hospital of Heilongjiang Hospital, Harbin, China.

Female infertility is a state of fertility disorder caused by multiple reasons. The incidence of infertility for females has significantly increased due to various factors such as social pressure, late marriage, and late childbirth, and its harm includes heavy economic burden, psychological shadow, and even marriage failure. Conventional solutions, such as hormone therapy, in vitro fertilization (IVF), and embryo transfer, have the limitations of unsatisfied obstetric outcomes and serious adverse events. Read More

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Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis.

Fertil Steril 2021 May 10. Epub 2021 May 10.

ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, 13075-460 Campinas, Brazil; Division of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, Brazil; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. Electronic address:

Objective: To evaluate the effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation (SDF) rates in infertile men with clinical varicocele.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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Chemotherapy-based gonadotoxicity risk evaluation as a predictor of reproductive outcomes in post-pubertal patients following ovarian tissue cryopreservation.

BMC Womens Health 2021 May 13;21(1):201. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: The sterilizing effect of cancer treatment depends mostly on the chemotherapy regimen and extent of radiotherapy. Prediction of long-term reproductive outcomes among cancer survivors according to chemo-radiotherapy regimen may improve pre-treatment fertility preservation counseling and future reproductive outcomes.

Methods: The aim of this study was to evaluate long term reproductive outcomes in cancer survivors according to gonadotoxicity risk estimation of the chemo-radiotherapy regimens utilized. Read More

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Ayurvedic management of female infertility due to tubal blockage.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Amrita School of Ayurveda, Amrita Viswavidyapeetham, Kollam, India.

Objectives: Secondary Infertility is a major concern worldwide, accounting for about 40% of female infertility due to lifestyle factor. Secondary Infertility is having a close proximity to a disorder explained in Ayurvedic classics, due to a variety of causes. Several Ayurvedic interventions are advised such as (∼purification therapy) for vitiated in female reproductive organs, (∼oral intake of medicated oil) followed by (∼purgation) to produce quality ovum. Read More

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Inhibition of human sperm motility and capacitation by ziram is mediated by decreasing tyrosine protein kinase.

Ecotoxicol Environ Saf 2021 May 10;218:112281. Epub 2021 May 10.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China. Electronic address:

Many endocrine disruptors may interfere with sperm motility, hyperactivation, and capacitation, thereby leading to male infertility. In the current study, we screened 14 endocrine disruptors, including plant ingredients, cigarette ingredients, minerals, insecticides and fungicides, plastics, and plasticizers, to inhibit human sperm motility and forward motility. Only ziram, a dithiocarbamate fungicide, can effectively inhibit sperm motility, forward motility, hyperactivation, capacitation, and spontaneous acrosome reaction of normal human spermatozoa. Read More

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The protective effect of zinc on morphine-induced testicular toxicity via p53 and Akt pathways: An in vitro and in vivo approach.

J Trace Elem Med Biol 2021 May 8;67:126776. Epub 2021 May 8.

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Background: Chronic use of morphine is associated with reproductive complications, such as hypogonadism and infertility. While the side effects of morphine have been extensively studied in the testis, much less is known regarding the effects of morphine on Sertoli cells and the effects of zinc on morphine-induced testicular injury as well as their underlying mechanisms. Therefore, the purpose of this study was to investigate the effect of morphine (alone and co-administered with zinc) on cell viability and apoptosis of the testicular (Sertoli) cells as well as the tumor suppressor p53 and phosphorylated-protein kinase B (p-Akt) protein levels in both in vitro and in vivo models. Read More

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Prevalence of endometriosis and peritoneal pockets in women with infertility and/or pelvic pain.

J Obstet Gynaecol Can 2021 May 10. Epub 2021 May 10.

Professor Emeritus, University of Tennessee Health Science Centre, Memphis Tennessee, USA; Institutional Review Board, Virginia Commonwealth University, Richmond, Virginia, USA.

Objective: To evaluate the prevalence of endometriosis and peritoneal pockets and to analyze whether these pockets are associated with pain.

Methods: Analysis of prospectively registered data of all women undergoing laparoscopy for infertility or pelvic pain between 1988 and 2011 at KU Leuven University Hospital.

Results: Of 4497 women, 191 had 238 pockets, with a prevalence of 4. Read More

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Men's perception and understanding of male-factor infertility in the UK.

Br J Nurs 2021 May;30(9):S8-S16

Consultant Urologist, Newcastle Fertility Centre, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne.

Male-factor infertility is a common but stigmatised issue, and men often do not receive the emotional support and the information they need. This study sought to understand awareness of male fertility issues compared to female fertility among the UK general male public, and also what were perceived as being the optimum methods for providing support for affected men, emotionally and through information. Men feel that male infertility is not discussed by the public as much as female infertility. Read More

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Association of obstructive sleep apnea risk with depression and anxiety symptoms in women with polycystic ovary syndrome.

J Clin Sleep Med 2021 May 13. Epub 2021 May 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, University of California San Francisco, San Francisco, California.

Study Objective: To determine whether obstructive sleep apnea (OSA) risk is associated with depression and anxiety symptoms in women with polycystic ovary syndrome (PCOS).

Methods: This is a cross-sectional study of women with PCOS, by the Rotterdam criteria, seen at a single academic center between June 2017 and June 2020. Depression symptoms, anxiety symptoms and OSA risk were assessed with self-administered Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7) and Berlin questionnaires, respectively. Read More

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Emerging progress on diagnosis and treatment of female genital tuberculosis.

J Int Med Res 2021 May;49(5):3000605211014999

Department of Respiratory Medicine, Jingzhou Chest Hospital, Jingzhou, Hubei, China.

Female genital tuberculosis (FGTB) is an infection caused by and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. Read More

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Male Infertility.

J Urol 2021 May 13:101097JU0000000000001860. Epub 2021 May 13.

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Late diagnosis of classic congenital adrenal hyperplasia: long-term consequences during adulthood.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Endocrinology, Diabetes and Metabolism Department, Coimbra Hospital and University Center, Coimbra, Portugal.

Summary: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders related to enzyme deficiencies in the adrenal steroidogenesis pathway leading to impaired corticosteroid biosynthesis. Depending on the extension of enzyme defect, there may be variable severities of CAH - classic and non-classic. We report the case of a 37-year-old male patient with a previously unknown diagnosis of classic CAH referred to Endocrinology evaluation due to class III obesity and insulin resistance. Read More

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Tribute to my sister: A new look at the X and O of Turner syndrome.

Nan Montgomery

Am J Med Genet C Semin Med Genet 2021 May 12. Epub 2021 May 12.

Addison/Ripley Fine Art, Washington, District of Columbia, USA.

This essay describes the author's reflections as a contemporary artist who was the sister of a woman with Turner syndrome. She reflects on the process of creating a painting which is literally about X and 0, but conveys deeper artistic and personal themes. Read More

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Does acquired obstructive azoospermia have less impact than congenital azoospermia on ICSI results? Systematic review and meta-analysis.

Andrologia 2021 May 12:e14096. Epub 2021 May 12.

Department of Urology, Centro Universitário FMABC, Santo André, Brazil.

An electronic-based search was performed with MEDLINE bases through PubMed, Cochrane through Central, and Embase until August 2020 for the purpose of evaluating the impact of the aetiology of obstructive azoospermia on ICSI cycles. In the final analysis, there were 15 cohort studies included, comparing a group of patients with acquired azoospermia and others due to congenital bilateral absence of the vas deferens submitted to ICSI. Those 15 articles within 4,480 couples were analysed, and similar fertilisation rate (65. Read More

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Correction to: Adipose tissue-derived stem cells: a comparative review on isolation, culture, and differentiation methods.

Cell Tissue Bank 2021 May 13. Epub 2021 May 13.

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Reproductive outcomes of microdissection testicular sperm extraction in hypogonadotropic hypogonadal azoospermic men after gonadotropin therapy.

J Assist Reprod Genet 2021 May 12. Epub 2021 May 12.

Department of Urology, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei, 11217, Taiwan.

Purpose: Male infertility caused by hypogonadotropic hypogonadism (HH) is not common. The main treatment is gonadotropins for 12 months or longer. If the patient is still azoospermic, conventional or microdissection testicular sperm extraction (mTESE) may further help in sperm retrieval. Read More

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A case presentation with tranverse testicular ectopia.

Urol Case Rep 2021 Sep 5;38:101674. Epub 2021 Apr 5.

Department of Ultrasonic Medicine, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.

Transverse testicular ectopia (TTE) is a rare congenital anomaly, in which both gonads migrate toward the same hemiscrotum with increased risk of testicular malignancy and associated with various abnormalities. Proper knowledge and imaging techniques are essential in diagnosis. Ultrasonography(USG) offer an easy, safe, and convenient alternative in assessment of TTE. Read More

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September 2021

A human infertility-associated KASH5 variant promotes mitochondrial localization.

Sci Rep 2021 May 12;11(1):10133. Epub 2021 May 12.

College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.

KASH5 is the most recently identified member of the KASH domain family of tail anchored, outer nuclear membrane (ONM) and endoplasmic reticulum (ER) proteins. During meiosis prophase I, KASH5 and SUN1 form a complex that spans the nuclear envelope and which links the telomeres of meiotic chromosomes to cytoplasmic dynein. This connection is essential for homologous chromosome dynamics and pairing. Read More

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Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.

Cell Death Dis 2021 May 12;12(5):478. Epub 2021 May 12.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

The spermatogenesis process is complex and delicate, and any error in a step may cause spermatogenesis arrest and even male infertility. According to our previous transcriptomic data, CEP70 is highly expressed throughout various stages of human spermatogenesis, especially during the meiosis and deformation stages. CEP70 is present in sperm tails and that it exists in centrosomes as revealed by human centrosome proteomics. Read More

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