91,285 results match your criteria Infertility


Effectiveness of shortened time interval to postpartum visit in improving postpartum attendance: Design and rationale for a randomized controlled trial.

Contemp Clin Trials 2019 Apr 17. Epub 2019 Apr 17.

The University of Vermont College of Medicine, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Smith 410, Main Campus, 111, Colchester, Avenue Burlington, VT 05401, USA.

Background/aims: Recent evidence suggests that there are numerous benefits to scheduling postpartum visits as early as 3 weeks post-delivery. However, findings are not conclusive due to methodological limitations. This report discusses the unique aspects of a randomized controlled trial's (RCT) design, intervention, and strategies to maintain participant retention. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.012DOI Listing

Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Aims: Increasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.043DOI Listing

Urocortinergic system in the epididymis of the normal and cryptorchid dogs.

Reprod Domest Anim 2019 Apr 20. Epub 2019 Apr 20.

Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.

Cryptorchidism is associated with changes in the gonads and the spermatic duct system, which may cause infertility problems. Urocortin (UCN) is a corticotrophin-releasing hormone (CRH)-related peptide, which affects several functions of male genital organs. The aim of the present study was to investigate the expression of UCN and its receptors CRHR1 and CRHR2 using immunohistochemistry, western blotting, and real-time reverse transcription polymerase chain reaction in tissues collected from the epididymis of normal and cryptorchid dogs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/rda.13443
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http://dx.doi.org/10.1111/rda.13443DOI Listing
April 2019
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Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with DSD (differences in sex development).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Elizabeth Garrett Anderson UCL Institute of Women's Health, University College London Hospitals, 250 Euston Road, London, NW12PG.

Discordance between gonadal type and gender identity has often led to an assumption of infertility in patients with differences in sex development (DSD). However, there is now greater recognition of fertility being an important issue for this group of patients. Currently, gonadal tissue that may have fertility potential is not being stored for individuals with DSD and, where gonadectomy forms part of management, is often discarded. Read More

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http://dx.doi.org/10.1111/cen.13994DOI Listing

Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice.

Biol Reprod 2019 Apr 20. Epub 2019 Apr 20.

Reproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan 430060, China.

Sulforaphane (SFN), a dietary isothiocyanate that is mainly found in cruciferous vegetables, possesses anti-oxidative and anticancer activity and modulates inflammation. However, little is known about the role of SFN in obesity-related male reproductive defects. The present study aimed to investigate the effects of SFN on high-fat diet (HFD)-induced male spermatogenic impairment and further clarify the possible underlying mechanisms. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz067DOI Listing
April 2019
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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. Read More

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http://dx.doi.org/10.1002/jcp.28666DOI Listing

The Possible Role of XRCC1 Gene Polymorphisms with Idiopathic Non-obstructive Azoospermia in Southeast Turkey.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing DNA damage during spermatogenesis. We examined the effects the possible role of two single nucleotide polymorphisms of XRCC1 Arg194Trp and Arg399Gln in DNA repair gene XRCC1 with risk of idiopathic non-obstructive azoospermia (INOA) in a south-east Turkey population.

Materials And Methods: The genotype and allele frequencies of two observed polymorphisms of XRCC1 Arg194Trp and Arg399Gln were examined by polymerase chain reaction-restriction fragment length polymorphism in 102 infertile men with INOA and 102 fertile controls. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4435DOI Listing
April 2019
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Nonsense mutation in causes normal-pressure hydrocephalus with ciliary abnormalities.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Departments of Neuropsychiatry (Y.M., N.Y., H.O.) and Otolaryngology-Head and Neck Surgery (C.S.), Unit of Translation Medicine, and Department of Human Genetics (S.Y., A.K., H.M., K.-i.Y., S.O.), Nagasaki University Graduate School of Biomedical Sciences; Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute (K.M., M.N.), Central Laboratory, Institute of Tropical Medicine (NEKKEN) (M.S.), and Gene Research Center, Center for Frontier Life Sciences (T.K.), Nagasaki University; Department of Infectious Diseases (T.T.) and Child and Adolescent Psychiatry Community Partnership Unit (A.I.), Nagasaki University Hospital; Department of Cell Pathology (Y.K.), Graduate School of Medical Sciences, Kumamoto University; and Department of Clinical Psychology, Faculty of Medicine (N.K.), Kagawa University, Takamatsu, Japan.

Objective: To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members with NPH.

Methods: We performed whole-exome sequencing (WES) on a Japanese family with multiple individuals with NPH and identified a candidate gene. Then we generated knockout mouse using CRISPR/Cas9 to confirm the effect of the candidate gene on the pathogenesis of hydrocephalus. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007505DOI Listing
April 2019
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Women's attitudes and beliefs about using fertility preservation to prevent age-related fertility decline-A two-year follow-up.

Patient Educ Couns 2019 Mar 28. Epub 2019 Mar 28.

Cardiff Fertility Studies Group, School of Psychology, Cardiff University, 70 Park Place, CF10 3AT, Cardiff, UK. Electronic address:

Objective: The health belief and transtheoretical model were used to describe how women make decisions about fertility preservation (FP) and identify factors that predict their decisions.

Methods: This is a two-year prospective study with 107 childless women aged 30-37. Women filled anonline survey assessing individual factors, intentions to do FP, variables of the health belief model, FP decisional stage and FP behaviour. Read More

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http://dx.doi.org/10.1016/j.pec.2019.03.019DOI Listing

The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678752
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http://dx.doi.org/10.1055/s-0039-1678752DOI Listing
November 2018
4 Reads

Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678753
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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018
1 Read

Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military.

Semin Reprod Med 2018 Nov 19;36(6):323-326. Epub 2019 Apr 19.

Walter Reed National Military Medical Center, Bethesda, Maryland.

The U.S. military mirrors the U. Read More

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http://dx.doi.org/10.1055/s-0039-1681084DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
1 Read

Semen quality is affected by HLA class I alleles together with sexually transmitted diseases.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), Porto, Portugal.

Background: The human leukocyte antigen (HLA) locus includes several genes with key roles in antigen presentation and immune response, some of them inclusively found to be associated with non-obstructive azoospermia. Still, HLA connections to other infertility phenotypes such as semen hyperviscosity (SHV), asthenozoospermia (AST), and oligozoospermia (OLI) have been often neglected.

Objectives: In this work, we aimed to evaluate the association of HLA class I and II genes with SHV, AST, and OLI phenotypes while exploring a possible role in an adaptive immune response to sexually transmitted diseases (STD). Read More

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http://dx.doi.org/10.1111/andr.12625DOI Listing

Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3112-3120

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Objective: Male infertility is a wide spread disease among couple of childbearing age. Spermatozoa are highly susceptible to oxidative stress. Reactive oxygen species (ROS) are capable of damaging the sperm membrane and DNA, inducing lipid peroxidation and sperm DNA fragmentation (SDF). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17595DOI Listing

GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial.

Int J Endocrinol 2019 13;2019:2487067. Epub 2019 Mar 13.

Department of OBGYN, Walter Reed National Military Medical Center, Bethesda, MD, USA.

This study is aimed at comparing clinical pregnancy rates (CPRs) in patients who are administered either gonadotropin-releasing hormone agonist (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. A total of 197 infertile women were randomly assigned to receive either GnRHa trigger ( = 98 cycles) or hCG trigger ( = 99 cycles) for ovulation trigger. Read More

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http://dx.doi.org/10.1155/2019/2487067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436329PMC

Memory T Cells in Pregnancy.

Front Immunol 2019 2;10:625. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Adaptations of the maternal immune response are necessary for pregnancy success. Insufficient immune adaption is associated with pregnancy pathologies such as infertility, recurrent miscarriage, fetal growth restriction, spontaneous preterm birth, and preeclampsia. The maternal immune system is continuously exposed to paternal-fetal antigens; through semen exposure from before pregnancy, through fetal cell exposure in pregnancy, and through microchimerism after pregnancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00625
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http://dx.doi.org/10.3389/fimmu.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455355PMC
April 2019
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Vitamin D Receptor Polymorphism and Male Factor Infertility - Letter To Editor.

J Pak Med Assoc 2019 Apr;69(4):603-604

Department of Biological and Biomedical Sciences, Aga Khan University Karachi, Pakistan.

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April 2019
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Evaluation of chromosomal abnormalities and Y chromosome microdeletion in infertile males of 10 families.

J Pak Med Assoc 2019 Apr;69(4):567-571

Khyber Medical University, Peshawar.

This study was designed to investigate the hormonal, seminal changes and chromosomal aberrations in cases of male infertility. A total of ten infertile families from Khyber Pakhtunkhwa of Pakistan were included in the study. The families were clinically evaluated by standard criteria; diagnosis of azoospermic and oligospermic males was confirmed. Read More

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High frequencies of Non Allelic Homologous Recombination (NAHR) events at the AZF loci and male infertility risk in Indian men.

Sci Rep 2019 Apr 18;9(1):6276. Epub 2019 Apr 18.

CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.

Deletions in the AZoospermia Factor (AZF) regions (spermatogenesis loci) on the human Y chromosome are reported as one of the most common causes of severe testiculopathy and spermatogenic defects leading to male infertility, yet not much data is available for Indian infertile men. Therefore, we screened for AZF region deletions in 973 infertile men consisting of 771 azoospermia, 105 oligozoospermia and 97 oligoteratozoospermia cases, along with 587 fertile normozoospermic men. The deletion screening was carried out using AZF-specific markers: STSs (Sequence Tagged Sites), SNVs (Single Nucleotide Variations), PCR-RFLP (Polymerase Chain Reaction - Restriction Fragment Length Polymorphism) analysis of STS amplicons, DNA sequencing and Southern hybridization techniques. Read More

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http://www.nature.com/articles/s41598-019-42690-0
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http://dx.doi.org/10.1038/s41598-019-42690-0DOI Listing
April 2019
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A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks.

EBioMedicine 2019 Apr 15. Epub 2019 Apr 15.

Institut Jacques Monod, Université Paris Diderot, CNRS UMR7592, Paris 75013, France; Université Paris Diderot-Paris 7, 75205 Paris Cedex 13, France. Electronic address:

Background: Primary Ovarian Insufficiency (POI), a major cause of infertility, affects about 1-3% of women under forty years of age. Although there is a growing list of causal genetic alterations, POI remains mostly idiopathic.

Methods: We performed exome sequencing (WES) of two sisters affected with POI, one unaffected sister and their mother from a consanguineous family. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.075DOI Listing

Feasibility of transabdominal Doppler ultrasonography for studying ovarian blood flow characteristics in cycling gilts.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):77-85. Epub 2019 Apr 18.

Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig.

Objective: The aim of this study was to assess ovarian blood flow characteristics by applying transabdominal color Doppler ultrasonography during the course of the estrous cycle in gilts.

Materials And Methods: Estrus and ovulation were synchronized in 15 pubertal gilts. During their consecutive spontaneous estrous cycle the gilts were sonographically scanned daily and ovarian blood flow was determined by imaging perfused areas of the ovarian hilus and the ovarian tissue. Read More

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http://dx.doi.org/10.1055/a-0858-0076DOI Listing

Effect of preconception low dose aspirin on pregnancy and live birth according to socioeconomic status: A secondary analysis of a randomized clinical trial.

PLoS One 2019 18;14(4):e0200533. Epub 2019 Apr 18.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.

Low socioeconomic status (SES) is associated with adverse pregnancy outcomes and infertility. Low-dose aspirin (LDA) was shown to improve livebirth rates in certain subsets of women, and therefore, may impact pregnancy rates differentially by SES status. Therefore, the aim of the current study was to examine whether daily preconception-initiated LDA affects rates of pregnancy, livebirth, and pregnancy loss differently across strata of socioeconomic status (SES). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200533PLOS
April 2019
2 Reads

Ovarian Reserve Testing: A Review of the Options, Their Applications, and Their Limitations.

Clin Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan.

Ovarian reserve refers to the number of oocytes remaining in a woman's ovaries that have the potential to yield a pregnancy. This is a concept based on the fact that the number of oocytes within a woman's ovaries and her ability to achieve pregnancy decline over time. There are 2 overlapping but distinct interpretations and utilizations of ovarian reserve testing (ORT)-biological and clinical. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000445DOI Listing

Deficiency of X-ray repair cross-complementing group 1 in primordial germ cells contributes to male infertility.

FASEB J 2019 Apr 18:fj201801962RR. Epub 2019 Apr 18.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China.

X-ray repair cross-complementing group 1 (), a key DNA repair gene, plays a vital role in maintaining genomic stability and is highly expressed in the early stages of spermatogenesis, but the exact functions remain elusive. Here we generated primordial germ cell-specific knockout (c) mice to elucidate the effects of on spermatogenesis. We demonstrated that deficiency results in infertility in male mice due to impaired spermatogenesis. Read More

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http://dx.doi.org/10.1096/fj.201801962RRDOI Listing

The incorporation of cystine by the soluble carrier family 7 member 11 (SLC7A11) is a component of the redox regulatory mechanism in stallion spermatozoa.

Biol Reprod 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, Cáceres, Spain.

Oxidative stress is considered a major mechanism causing sperm damage during cryopreservation and storage, and underlies male factor infertility. Currently, oxidative stress is no longer believed to be caused only by the overproduction of reactive oxygen species, but rather by the deregulation of redox signaling and control mechanisms. With this concept in mind, here, we describe for the first time the presence of the soluble carrier family 7 member 11 (SLC7A11) antiporter, which exchanges extracellular cystine (Cyss) for intracellular glutamate, in stallion spermatozoa, as well as its impact on sperm function using the specific inhibitor sulfasalazine. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz069DOI Listing
April 2019
1 Read

Assessment of Radiation Safety Knowledge Among Urology Residents in the United States.

J Endourol 2019 Apr 18. Epub 2019 Apr 18.

University of Kentucky, 4530, Urology, Lexington, Kentucky, United States ;

Introduction: Urologists are increasingly exposed to fluoroscopy, which can cause cellular damage. Appropriate knowledge and safety precautions concerning fluoroscopy are necessary and ideally should be taught in training. We sought to assess radiation safety knowledge among Urology residents in the United States. Read More

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https://www.liebertpub.com/doi/10.1089/end.2019.0133
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http://dx.doi.org/10.1089/end.2019.0133DOI Listing
April 2019
1 Read

Elevated temperature modulates rice pollen structure: a study from foothill of Himalayan agro-ecosystem in India.

3 Biotech 2019 May 11;9(5):175. Epub 2019 Apr 11.

3Forest Ecology and Climate Change Division, Forest Research Institute, Dehradun, Uttarakhand India.

Rice cultivation is practiced in various agro-climatic zones ranging from tropical to temperate. Anthesis is a critical stage for deciding productivity which is controlled by numerous biotic and abiotic stresses. Elevated temperature is one of the key abiotic stresses that adversely modulate the pollen formation and structure, i. Read More

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http://dx.doi.org/10.1007/s13205-019-1700-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459444PMC

Heterotopic pregnancy with suspicion of superfetation after the intrauterine insemination cycle with ovulation induction using clomiphene citrate: A case report.

Clin Pract 2019 Jan 25;9(1):1129. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, Ageo Central General Hospital, Ageo-shi, Saitama-ken.

At 22 days after intrauterine insemination with ovulation induction using clomiphene citrate at a previous hospital, a 30-year-old woman was admitted to our hospital owing to right lower quadrant abdominal pain. We diagnosed threatened abortion because of a gestational sac in the uterus on transvaginal ultrasonography. The next day, she complained of increased abdominal pain. Read More

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http://dx.doi.org/10.4081/cp.2019.1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444374PMC
January 2019
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Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

Reprod Med Biol 2019 Apr 28;18(2):151-160. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood. This can be addressed using appropriate animal models of PCOS. In this review, we describe rodent models of hormone-induced PCOS that focus on the perturbation of the hypothalamic-pituitary-ovary (HPO) axis and abnormalities in neuropeptide levels. Read More

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http://dx.doi.org/10.1002/rmb2.12262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452010PMC

Klinefelter syndrome: From pediatrics to geriatrics.

Reprod Med Biol 2019 Apr 8;18(2):140-150. Epub 2018 Dec 8.

Department of Urology Yamaguchi University School of Medicine Ube Japan.

Background: Klinefelter syndrome (KS) is one of the major causes of nonobstructive azoospermia (NOA). Microdissection testicular sperm extraction (micro-TESE) is often performed to retrieve sperm. Infertility specialists have to care for KS patients on a lifelong basis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rmb2.12261
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http://dx.doi.org/10.1002/rmb2.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452011PMC
April 2019
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Rare case of an oligospermic male with 46,XX/46,XY tetragametic chimerism.

Andrologia 2019 Apr 17:e13290. Epub 2019 Apr 17.

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Chimerism, a rare human disorder, is assumed to be the result of an amalgamation of two separate zygotes in a single embryo. Studies have shown that the phenotypic spectrum of chimerism is variable and there is no definite genotype-phenotype correlation in patients with chimerism, therefore a majority of cases might remain undiagnosed. This study aims to investigate the possible mechanism of the chimerism in a 46,XX/46,XY infertile and phenotypically normal male, with 46,XX blood karyotype and normal spermatogenesis. Read More

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http://dx.doi.org/10.1111/and.13290DOI Listing
April 2019
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The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis.

Andrologia 2019 Apr 17:e13292. Epub 2019 Apr 17.

Faculty of Medicine, Department of Biostatistics, Inonu University, Malatya, Turkey.

Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. Read More

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http://dx.doi.org/10.1111/and.13292DOI Listing
April 2019
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Risk of Severe Maternal Morbidity by Maternal Fertility Status: A US study in 8 States.

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Center for Assisted Reproduction, Bedford, Texas.

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193057
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http://dx.doi.org/10.1016/j.ajog.2019.04.011DOI Listing
April 2019
2 Reads

Fresh IVF cycles increase risk of SGA, Frozen Cycles increase risk of LGA: Which is Worse?

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Tripler Army Medical Center, Hawaii.

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http://dx.doi.org/10.1016/j.ajog.2019.04.010DOI Listing
April 2019
1 Read

Deletion of maternal UHRF1 severely reduces mouse oocyte quality and causes developmental defects in preimplantation embryos.

FASEB J 2019 Apr 17:fj201801696RRRR. Epub 2019 Apr 17.

Department of Histology and Embryology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

The ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) protein recognizes DNA methylation and histone modification and plays a critical role in epigenetic regulation. Recently, UHRF1 was shown to have a role in DNA methylation in oocytes and early embryos. Here, we reveal that maternal UHRF1 determines the quality of mouse oocytes. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801696RRRR
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http://dx.doi.org/10.1096/fj.201801696RRRRDOI Listing
April 2019
2 Reads

Endometriosis.

Endocr Rev 2019 Apr 17. Epub 2019 Apr 17.

Departments of Obstetrics and Gynecology, Northwestern University, Chicago, IL.

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. Read More

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http://dx.doi.org/10.1210/er.2018-00242DOI Listing
April 2019
1 Read
21.059 Impact Factor

Reality of premature ovarian failure in Argentina.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):419-423. Epub 2019 Apr 11.

Argentinian Society of Gynecological and Reproductive Endocrinology, Buenos Aires, Argentina.

Premature Ovarian Insufficiency is defined as a decline in ovarian function that is accompanied by two biochemical determinations of Follicle Stimulating Hormone in hypergonadotropic values, in addition to low levels of circulating estrogens in women under 40 years old. Although some of its possible etiologies are recognized and diagnosed, most of the time, its cause remains unknown. It is a pathology with medical, psychological, and reproductive implications. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.419DOI Listing
March 2019
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Contemporary Management of Unexplained Infertility.

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York.

Infertility is estimated to affect about 10% to 15% of couples. Most cases of infertility have etiologies that can be attributed to tubal factors, ovulatory dysfunction, endometriosis, uterine factor, male factor, or diminished ovarian reserve, while the remainder often do not have a known attributable cause, that is, unexplained infertility. The current manuscript summarizes the contemporary management of unexplained infertility. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000450DOI Listing
April 2019
2 Reads

Anti-Müllerian Hormone and its Predictive Utility in Assisted Reproductive Technologies Outcomes.

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut.

Anti-Müllerian hormone (AMH) has become one of the most informative biochemical markers of the ovary and is considered the earliest and most sensitive marker of reproductive aging. The accuracy of AMH in predicting ovarian response to controlled ovarian stimulation has led to AMH-based prognostication counseling and individualization of assisted reproductive technology (ART) stimulation protocols to optimize ovarian response and minimize hyperstimulation risks. Although AMH is considered a good predictor of quantitative ART outcomes, its correlation with qualitative ART outcomes is still controversial. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000436DOI Listing
April 2019
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Differential recognition of diet-derived Neu5Gc-neoantigens on glycan microarrays by carbohydrate-specific pooled human IgG and IgA antibodies.

Bioconjug Chem 2019 Apr 17. Epub 2019 Apr 17.

Sialic acids (Sias) cover vertebrate cell surface glycans. N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc) are common Sia in mammals. Humans cannot synthesize Neu5Gc, but accumulate it on cells through red-meat rich diets, generating numerous immunogenic Neu5Gc-neoantigens. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00273DOI Listing
April 2019
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Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2-mTOR pathway.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetic, Facualty of Medcine, Tabriz University of Medical Sciences, Tabriz, Iran.

Successful implantation of embryos requires endometrial receptivity. Glucocorticoids are one of the factors influencing the implantation window. In this study, 40 female BALB/c mice were used to study the impacts of dexamethasone administration on endometrial receptivity markers during implantation window. Read More

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http://dx.doi.org/10.1002/jcp.28562DOI Listing
April 2019
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Gene discovery informatics toolkit defines candidate genes for unexplained infertility and prenatal or infantile mortality.

NPJ Genom Med 2019 15;4. Epub 2019 Apr 15.

1Kids Neuroscience Centre, Kids Research, Children's Hospital at Westmead, Sydney, NSW 2145 Australia.

Despite a recent surge in novel gene discovery, genetic causes of prenatal-lethal phenotypes remain poorly defined. To advance gene discovery in prenatal-lethal disorders, we created an easy-to-mine database integrating known human phenotypes with inheritance pattern, scores of genetic constraint, and murine and cellular knockout phenotypes-then critically assessed defining features of known prenatal-lethal genes, among 3187 OMIM genes, and relative to 16,009 non-disease genes. While around one-third (39%) of protein-coding genes are essential for murine development, we curate only 3% (624) of human protein-coding genes linked currently to prenatal/infantile lethal disorders. Read More

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http://dx.doi.org/10.1038/s41525-019-0081-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465277PMC
April 2019
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Discovery of non-invasive biomarkers for the diagnosis of endometriosis.

Clin Proteomics 2019 6;16:14. Epub 2019 Apr 6.

1Department of Women's Cancer, Institute for Women's Health, University College London, Cruciform Building 1.1, Gower Street, London, WC1E 6BT UK.

Background: Endometriosis is a common gynaecological disorder affecting 5-10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potentially serious complications, and is often delayed. Non-invasive biomarkers are urgently required to accelerate diagnosis and for triaging potential patients for surgery. Read More

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https://clinicalproteomicsjournal.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s12014-019-9235-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451201PMC
April 2019
3 Reads

[Controlling the spatiotemporal expression of germ line specific genes by PRC1.6 complex].

Yi Chuan 2019 Apr;41(4):271-284

School of Life Sciences, Lanzhou University, Lanzhou 730000, China.

Polycomb repressive complex 1 (PRC1) is a class of epigenetic regulatory complexes that normally represses gene expression by catalyzing and/or recognizing chromatin modifications. PRC1 mainly functions in stem cell maintenance, cell differentiation, cell cycle regulation and related processes. PRC1 also have aberrant functions which has been implicated in many types of developmental diseases and cancers. Read More

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http://www.cnki.net/kcms/doi/10.16288/j.yczz.18-332.html
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http://dx.doi.org/10.16288/j.yczz.18-332DOI Listing
April 2019
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Screening hysteroscopy in subfertile women and women undergoing assisted reproduction.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012856. Epub 2019 Apr 16.

Department of Reproductive Medicine, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India, 632004.

Background: Screening hysteroscopy in infertile women with unexplained infertility, or prior to intrauterine insemination (IUI) or in vitro fertilisation (IVF) may reveal intrauterine pathology that may not be detected by routine transvaginal ultrasound. Hysteroscopy, whether purely diagnostic or operative may improve reproductive outcomes.

Objectives: To assess the effectiveness and safety of screening hysteroscopy in subfertile women undergoing evaluation for infertility, and subfertile women undergoing IUI or IVF. Read More

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http://dx.doi.org/10.1002/14651858.CD012856.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472583PMC
April 2019
2 Reads

Deep MS/MS-Aided Structural-similarity Scoring for Unknown Metabolites Identification.

Anal Chem 2019 Apr 16. Epub 2019 Apr 16.

Tandem mass spectrometry (MS/MS) is the workhorse for structural annotation of metabolites, because it can provide abundance of structural information. Currently, metabolite identification mainly relies on querying experimental spectra against public or in-house spectral databases. The identification is severely limited by the available spectra in the databases. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b05405DOI Listing
April 2019
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Hot topics in male infertility: an afterword.

Panminerva Med 2019 Jun;61(2):196-199

Faculty of Health, Aarhus University, Aarhus, Denmark.

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https://www.minervamedica.it/index2.php?show=R41Y2019N02A019
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http://dx.doi.org/10.23736/S0031-0808.18.03587-5DOI Listing
June 2019
2 Reads
2.276 Impact Factor

Indications and outcomes of varicocele repair.

Panminerva Med 2019 Jun;61(2):152-163

American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA -

Varicoceles exert deleterious effect on testicular function. The condition has been associated with male infertility, testicular hypotrophy and pain. These comprises the common indications for varicocele repair currently. Read More

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http://dx.doi.org/10.23736/S0031-0808.18.03528-0DOI Listing
June 2019
1 Read
2.276 Impact Factor

Clinical utility of sperm DNA damage in male infertility.

Panminerva Med 2019 Jun;61(2):118-127

ANDROFERT Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, Brazil.

Sperm DNA fragmentation (SDF) is an advanced test of sperm function that is utilized during male fertility evaluation. Recently, a guideline was published highlighting the detrimental impact of SDF on sperm function identifying practice-based clinical indications for SDF testing. This review illustrates the commonly utilized SDF measurement techniques and explores the current evidence behind their utility in clinical practice. Read More

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https://www.minervamedica.it/index2.php?show=R41Y2019N02A011
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http://dx.doi.org/10.23736/S0031-0808.18.03530-9DOI Listing
June 2019
2 Reads
2.276 Impact Factor