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    1 OF 735

    Ruptured mitral valve aneurysm: A devastating complication of aortic valve endocarditis.
    Echocardiography 2018 Mar 22. Epub 2018 Mar 22.
    Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Science, Teheran, Iran.
    Mitral valve aneurysm is a rare clinical entity that is mostly resulted from infective endocarditis, in particular, aortic valve endocarditis. Once mitral valve aneurysm ruptures and severe mitral regurgitation and hemodynamic instability develop, prompt surgery should be considered. Here we report a patient with ruptured mitral valve aneurysm associated with native aortic valve endocarditis that was improved after a successful mitral and aortic valve replacement surgery associated with antibiotic therapy for 6 weeks. Read More

    Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium.
    J Thorac Cardiovasc Surg 2018 Feb 15. Epub 2018 Feb 15.
    Department of Cardiovascular Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.
    Objective: We had previously reported the short-term results of the aortic valve neocuspidization (AVNeo) procedure. We have now evaluated the midterm results with the longest follow-up of 118 months.

    Methods: From April 2007 through December 2015, 850 patients were treated with AVNeo using autologous pericardium. Read More

    Distribution of streptococcal groups causing infective endocarditis: a descriptive study.
    Diagn Microbiol Infect Dis 2018 Feb 24. Epub 2018 Feb 24.
    Department of Infectious Diseases, Cleveland Clinic, 9500 Euclid Avenue, G21, Cleveland, OH 44195, USA. Electronic address:
    The purpose of this study was to describe the distribution of streptococci causing infective endocarditis (IE). A total of 296 patients with definite IE admitted from July 2007 to December 2014 were identified, with microbial identification done by a combination of blood culture, valve culture, and valve polymerase chain reaction (PCR). The overall distribution of streptococci was 76% viridans (n = 224), 17% pyogenic (50), 6% nutritionally variant (17), and 2% anaerobic (5). Read More

    Transcatheter Pulmonary Valve Replacement With the Melody Valve in Small Diameter Expandable Right Ventricular Outflow Tract Conduits.
    JACC Cardiovasc Interv 2018 Mar;11(6):554-564
    Division of Pediatric Cardiology, Lucille Packard Children's Hospital at Stanford University, Palo Alto, California; Department of Pediatrics, Lucile Packard Children's Hospital Heart Center, Stanford University School of Medicine, Palo Alto, California; Department of Cardiothoracic Surgery, Lucile Packard Children's Hospital Heart Center, Stanford University School of Medicine, Palo Alto, California.
    Objectives: This study sought to evaluate the safety, feasibility, and outcomes of transcatheter pulmonary valve replacement (TPVR) in conduits ≤16 mm in diameter.

    Background: The Melody valve (Medtronic, Minneapolis, Minnesota) is approved for the treatment of dysfunctional right ventricular outflow tract (RVOT) conduits ≥16 mm in diameter at the time of implant. Limited data are available regarding the use of this device in smaller conduits. Read More

    A case of Cardiobacterium valvarum endocarditis with cerebral hemorrhage after MVR, TVP and vegetation removal operation.
    Ann Clin Microbiol Antimicrob 2018 Mar 22;17(1):11. Epub 2018 Mar 22.
    Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
    Background: Cardiobacterium is a fastidious Gram-negative bacillus, and is a rare human pathogen in clinical settings. Herein, we describe a case of Cardiobacterium valvarum (C. valvarum) endocarditis with a rare complication of cerebral hemorrhage after mitral valve replacement (MVR), tricuspid valve prosthesis (TVP) and vegetation removal operation. Read More

    Investigation of bacteremia after debonding procedures.
    Acta Odontol Scand 2018 Mar 23:1-6. Epub 2018 Mar 23.
    c Department of Microbiology , Gaziantep University , Gaziantep , Turkey.
    Objective: The purpose of this study is to investigate the effect of debonding procedures after completion of orthodontic treatments on bacteremia.

    Materials And Methods: Twenty-eight patients who were treated with fixed orthodontic treatment at the Faculty of Dentistry's Department of Orthodontics at Gaziantep University and who had an indication of debonding were selected for this study, and blood samples were taken from these patients at different times and examined for bacteremia. Blood culture samples were taken from the antecubital veins of the patients prior to debonding (T), immediately after removing the bracket (T), and immediately after cleaning the composite residues and plaque deposits on the enamel surface (T). Read More

    Echocardiography has low utility in cancer patients with Staphylococcus aureus bacteraemia: findings from a retrospective study.
    Support Care Cancer 2018 Mar 21. Epub 2018 Mar 21.
    Department of Medical Oncology & Clinical Haematology, Olivia Newton John Cancer Research and Wellness Centre, Austin Health, Heidelberg, Victoria, Australia.
    Aim: To describe the incidence of infective endocarditis (IE) detected on echocardiography in cancer patients with confirmed Staphylococcus aureus bacteraemia (SAB).

    Methods: We retrospectively identified 95 cases of SAB in cancer patients from January 2007-March 2016. Echocardiography was ordered at the discretion of the treating team, and positive findings defined according to the Modified Duke Criteria. Read More

    A case ofendocarditis in a patient with cardiovascular implantable electronic device.
    Infect Drug Resist 2018 9;11:387-390. Epub 2018 Mar 9.
    Department of Internal Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
    Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Read More

    Infective Endocarditis Associated with Atopic Dermatitis.
    Int Heart J 2018 Mar 20. Epub 2018 Mar 20.
    Department of Cardiovascular Surgery, St. Mary's Hospital.
    We report a case of aortic valve infective endocarditis (IE) in a 24-year-old man with atopic dermatitis (AD). He had a history of balloon valvuloplasty for a stenotic bicuspid aortic valve, and had dental caries but no invasive dental procedure before the onset of IE. On admission, skin lesions of AD with itching and scratches were found on the neck, trunk, and extremities. Read More

    A rare cause of healthcare-associated infective endocarditis:.
    IDCases 2018 6;12:18-20. Epub 2018 Mar 6.
    Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
    We report a case of infective endocarditis secondary to healthcare-associated bloodstream infection caused by an uncommon etiologic agent, multidrug-resistant. The patient was treated with a combination of antimicrobial therapy and surgery, but could not be saved. With this case, we discuss the prevalence, risk factors, treatment options, and outcomes of the rarely encountered-associated infective endocarditis. Read More

    A dairy worker with fever and an abnormal echocardiogram.
    Heart Asia 2017 11;9(2):e010915. Epub 2017 Jul 11.
    Department of Cardiology, Christian Medical College and Hospital, Vellore, India.
    Description Of The Case: A 38-year-old male presented with history of progressively increasing dyspnoea of 25 days duration. He gave history of low -grade fever associated with malaise and weight loss over the preceding 6 months. He worked in the dairy industry in the Middle East and returned to India owing to his illness. Read More

    A Case of Anterior Spinal Artery Syndrome Caused byEndocarditis.
    Case Rep Med 2018 29;2018:9658120. Epub 2018 Jan 29.
    Department of Infectious Disease, Jersey Shore University Medical Center, Neptune, NJ, USA.
    Background: Infectious endocarditis (IE) typically occurs in the setting of intravenous drug use, prosthetic heart valves, or rheumatic heart disease. However, there are a few reports of IE occurring in the setting of immunosuppression secondary to cancer and/or chemotherapy. Here, we present a case of a cancer patient who developed anterior spinal artery (ASA) syndrome secondary to a septic embolus from IE. Read More

    Mycotic Pulmonary Artery Aneurysm Mimicking a Rasmussen Aneurysm.
    Ochsner J 2018 ;18(1):104-107
    Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA.
    Background: Mycotic aneurysms arising from the pulmonary arteries are rare; only a few cases have been reported.andspecies are the most common causative pathogens. Mycotic aneurysms are seldom clinically apparent unless as a sequela of adverse procedural complications. Read More

    Infective endocarditis in neutropenic patients with viridans streptococci bacteraemia.
    Clin Microbiol Infect 2018 Mar 17. Epub 2018 Mar 17.
    University Hospital, Universidade Federal do Rio de Janeiro. Electronic address:
    Viridans streptococci (VS) are important agents of bacteraemia in neutropenic patients and important agents of community-acquired infective endocarditis (IE) in non-neutropenic patients. However, the incidence of IE in neutropenic patients seems to be rare. In this systematic review of the literature we sought to answer the following questions: (1) What is the frequency of IE in neutropenic patients with VS bacteraemia? (2) What is the most frequent clinical presentation of IE? (3) Is routine investigation for IE indicated in neutropenic patients with VS bacteraemia? The incidence of IE in patients with VS bacteraemia was 0. Read More

    Cerebral Microbleeds: Imaging and Clinical Significance.
    Radiology 2018 Apr;287(1):11-28
    From the Affidea Centre de Diagnostic Radiologique de Carouge (CDRC), Geneva, Switzerland (S.H.); Faculty of Medicine, University of Geneva, Geneva, Switzerland (S.H.); Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden (S.H., E.M.L.); Department of Neuroradiology, University Hospital Freiburg, Freiburg, Germany (S.H.); Department of Radiology and Nuclear Medicine and Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands (M.W.V.); Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands (J.P.A.K., F.B.); Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, England (H.R.J., F.B.).
    Cerebral microbleeds (CMBs), also referred to as microhemorrhages, appear on magnetic resonance (MR) images as hypointense foci notably at T2*-weighted or susceptibility-weighted (SW) imaging. CMBs are detected with increasing frequency because of the more widespread use of high magnetic field strength and of newer dedicated MR imaging techniques such as three-dimensional gradient-echo T2*-weighted and SW imaging. The imaging appearance of CMBs is mainly because of changes in local magnetic susceptibility and reflects the pathologic iron accumulation, most often in perivascular macrophages, because of vasculopathy. Read More

    Lethal endomyocarditis caused by chronic "Krokodil" intoxication.
    Forensic Sci Med Pathol 2018 Mar 19. Epub 2018 Mar 19.
    Department of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, Bari, Italy.
    "Krokodil" is a home-made opioid drug obtained by synthesizing desomorphine from codeine and combining it with other low-cost additives. Initially introduced in the former Soviet countries, it was then imported to Western Europe as a heroin substitute. To our knowledge, this is the first report of an Italian case of lethal krokodil abuse, that occurred in a 39-year-old man, who died suddenly after transportation to the Emergency Department (ED) for hyperthermia associated with sweating, dyspnoea and tachycardia. Read More

    Beyond Standard Echocardiography in Infective Endocarditis: Computed Tomography, 3-Dimensional Imaging, and Multi-Imaging.
    Circ Cardiovasc Imaging 2018 Mar;11(3):e007626
    From the Department of Cardiology, Assistance Publique Hopitaux de Marseille, La Timone Hospital, Marseille, France; and Aix Marseille Université, IRD, Assistance Publique Hopitaux de Marseille, MEPHI, IHU-Méditerranée Infection, France.

    Comparison of Cardiac Computed Tomography With Transesophageal Echocardiography for Identifying Vegetation and Intracardiac Complications in Patients With Infective Endocarditis in the Era of 3-Dimensional Images.
    Circ Cardiovasc Imaging 2018 Mar;11(3):e006986
    From the Division of Cardiology, Severance Cardiovascular Hospital (I.-C.K., G.-R.H., J.-W.H., C.Y.S.), Department of Cardiovascular Surgery, Severance Cardiovascular Hospital (S.H.L., S.L., B.-C.C.), and Department of Radiology, Research Institute of Radiological Science, Severance Hospital (S.C., Y.J.K.), Yonsei University College of Medicine; and Division of Cardiology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University (I.-C.K.).
    Background: Recent evolution of cardiac computed tomography (CT) provides useful information about valvular and perivalvular structures. We compared the diagnostic performance of CT and transesophageal echocardiography (TEE) with applications of 3-dimensional reconstruction in detecting vegetation and intracardiac complications in patients with infective endocarditis (IE).

    Methods And Results: Seventy-five patients (53 men; age, 58±15 years) with definite IE who underwent TEE and CT with 3-dimensional reconstruction within 3 days were analyzed. Read More

    Molecular survey of neglected bacterial pathogens reveals an abundant diversity of species and genotypes in ticks collected from animal hosts across Romania.
    Parasit Vectors 2018 Mar 20;11(1):144. Epub 2018 Mar 20.
    Institute for Diagnosis and Animal Health, Bucharest, Romania.
    Background: Ticks are transmitting a wide range of bacterial pathogens that cause substantial morbidity and mortality in domestic animals. The full pathogen burden transmitted by tick vectors is incompletely studied in many geographical areas, and extensive studies are required to fully understand the diversity and distribution of pathogens transmitted by ticks.

    Results: We sampled 824 ticks of 11 species collected in 19 counties in Romania. Read More

    Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation.
    Thromb Haemost 2018 Mar 19. Epub 2018 Mar 19.
    Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
    can cause bloodstream infections associated with infective endocarditis (IE) and disseminated intravascular coagulopathy (DIC). Both complications involve platelets. In view of an increasing number of antibiotic-resistant strains, new approaches to control systemicinfection are gaining importance. Read More

    Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA.
    Emerg Infect Dis 2018 Apr;24(4)
    The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure brown heroin in the 1970s-1990s; however, candidiasis accompanying IVDU became considerably rarer as the purity of the heroin supply increased. We reviewed cases of candidemia occurring over a recent 7-year period in persons >14 years of age at a tertiary care hospital in central Massachusetts. Read More

    Efficacy of Glutaraldehyde-Treated Leaflets for Mitral Valve Repair to Treat Active Infective Endocarditis: A Case Report.
    Ann Thorac Cardiovasc Surg 2018 Mar 16. Epub 2018 Mar 16.
    Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
    We report the use of glutaraldehyde (GA) in a case of valve repair for mitral valve prolapse associated with active infective endocarditis. GA scrubbed at the site of infection decontaminates and reinforces infected fragile tissue, avoids excessive debridement, and strengthens the edges of valve leaflets to facilitate suturing. Read More

    Cardiac implantable electronic device and vascular access: Strategies to overcome problems.
    J Vasc Access 2018 Mar 1:1129729818762981. Epub 2018 Mar 1.
    2 Cardiology Department, Centre for Heart Diseases, Military Hospital, Wroclaw, Poland.
    For arrhythmia treatment or sudden cardiac death prevention in hemodialysis patients, there is a frequent need for placement of a cardiac implantable electronic device (pacemaker, implantable cardioverter defibrillator, or cardiac resynchronization device). Leads from a cardiac implantable electronic device can cause central vein stenosis and carry the risk of tricuspid regurgitation or contribute to infective endocarditis. In patients with end-stage kidney disease requiring vascular access and cardiac implantable electronic device, the best strategy is to create an arteriovenous fistula on the contralateral upper limb for a cardiac implantable electronic device and avoidance of central vein catheter. Read More

    Coxiella burnetii endocarditis on bioprosthetic aortic valve, with peripheral arterial embolism.
    Cardiovasc Pathol 2018 Feb 16;34:38-39. Epub 2018 Feb 16.
    Department of Nephrology, AP-HP, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
    Acute limb ischemia related to Coxiella burnetii endocarditis is rare. We report an original case of a 68-year-old man hospitalized for recurrent acute left limb ischemia in a context of atrial flutter, which revealed C. burnetii endocarditis. Read More

    Valve-sparing root replacement for freestanding pulmonary autograft aneurysm after the Ross procedure.
    J Thorac Cardiovasc Surg 2018 Feb 20. Epub 2018 Feb 20.
    Department of Cardiothoracic and Vascular Surgery, Kepler University Hospital, Linz, Austria.
    Objective: Autograft dilatation is the main long-term complication following the Ross procedure using the freestanding root replacement technique. We reviewed our 25-year experience with the Ross procedure with a special emphasis on valve-sparing reoperations.

    Methods: From 1991 to 2016, 153 patients (29. Read More

    Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.
    Am J Med Sci 2018 Mar 20;355(3):293-298. Epub 2017 Jul 20.
    Department of Medicine, Medical University of South Carolina, Charleston, SC. Electronic address:
    Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE). Nested case-control study was conducted with 70 patients with SLE selected from a longitudinal database based on levels of aPL and presence or absence of valve disease by echocardiogram. Valvular abnormalities observed were regurgitation (52), other (14), artificial valves (4), stenosis (2), thickening (2) and no Libman-Sacks endocarditis (0). Read More

    Re-repair of the failed mitral valve: insights into aetiology and surgical management.
    Eur J Cardiothorac Surg 2018 Mar 14. Epub 2018 Mar 14.
    Department of Thoracic and Cardiovascular Surgery, Catholic University of Louvain, Saint Luc Hospital, Brussels, Belgium.
    Objectives: Mitral valve (MV) repair is the gold standard for treatment of degenerative mitral regurgitation. A variety of surgical techniques allow surgeons to achieve a high rate of MV repair even with MV diseases of other aetiologies. However, a certain number of repairs fail over time. Read More

    [Streptococcus pneumoniae endocarditis in a child: a case report].
    Rev Chil Pediatr 2017 Dec;88(6):776-780
    Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
    Introduction: the incidence of invasive infections caused by pneumococcus (Streptococcus pneumoniae) has declined since generalized vaccination with pneumococcal conjugated vaccine, but it is still a prevalent pathogen in children. Amongst pneumococcal invasive infections, IE (infectious endocarditis) is rare, with an incidence between 1 and 7%.

    Case Report: We describe the case of a previously healthy 4 year old boy, who had received one dose of 10-valent pneumococcal conjugate vaccine who presents with fever, a new heart murmur and heart failure. Read More

    Diagnostic accuracy of transthoracic echocardiography to identify native valve infective endocarditis: a systematic review and meta-analysis.
    Intern Emerg Med 2018 Mar 15. Epub 2018 Mar 15.
    Internal Medicine Department, Ca' Granda Foundation IRCCS, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
    Infective endocarditis (IE) is a serious and potentially life-threatening disease, and accurate diagnosis is essential. We performed a systematic review and meta-analysis to assess the diagnostic accuracy of transthoracic echocardiography (TTE), with transesophageal echocardiography (TEE) as the reference standard, in patients with suspected IE of the native valves. We performed a systematic search in MEDLINE, EMBASE and Cochrane Library searching for studies that enrolled adult patients with suspected native valves IE where data about both TTE and TEE could be extracted. Read More

    RE: 'Streptococcus: A novel human pathogen?'
    Int J Surg Case Rep 2017 20;41:493-494. Epub 2017 Nov 20.
    Rostock University Medical Center, Division of Tropical Medicine and Infectious Diseases, Ernst-Heydemann-Strasse 6, 18057 Rostock, Germany.
    Streptococcus pluranimalium as a novel human pathogen has been reported by several authors in various contexts. In all reported cases in humans the microorganism was detected by the Vitek2. The great advances with the introduction of new analytical techniques such as MALDI-TOF or 16S rRNA analysis enabled a more detailed discrimination of pathogens such as these nonhemolytic streptococci. Read More

    Infected symptomatic carotid artery atheroma concurrent with bacterial endocarditis.
    BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
    Optimal management of patients with stroke due to symptomatic carotid artery disease coexistent with bacterial endocarditis is still not well established. We report the case of a patient who presented with multifocal left middle cerebral artery stroke in the setting ofendocarditis and was found to have near-occlusive ipsilateral carotid artery stenosis in stroke workup. Carotid artery endarterectomy was performed, and atheroma material demonstrated complicated plaque with cultures positive forThis report demonstrates that patients with cardioembolic disorders such as bacterial endocarditis with vegetations who present with stroke may benefit from evaluation for extracranial vessel stenosis. Read More

    [Serum albumin and cardiovascular diseases: A comprehensive review of the literature].
    Ann Cardiol Angeiol (Paris) 2018 Mar 12. Epub 2018 Mar 12.
    Service de cardiologie, centre hospitalier Edmond-Garcin, avenue des Soeurs-Gastine, 13400 Aubagne, France. Electronic address:
    Cardiovascular diseases are the leading cause of death worldwide. Conceptually, endothelial dysfunction, inflammatory status and oxidative stress are at the forefront in the onset and development of most cardiovascular diseases, particularly coronary artery disease and heart failure. Serum albumin, the most abundant plasma protein, has many physiological properties, including anti-inflammatory, antioxidant and antiplatelet aggregation activity. Read More

    Percutaneous pulmonary valve implantation in patients with dysfunction of a "native" right ventricular outflow tract - Mid-term results.
    Int J Cardiol 2018 May;258:31-35
    Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center, Munich, Germany.
    Background: To investigate the feasibility and mid-term results of percutaneous pulmonary valve implantation (PPVI) in patients with conduit free or "native" right ventricular outflow tracts (RVOT).

    Methods And Results: We identified all 18 patients with conduit free or "native" right ventricular outflow tract, who were treated with percutaneous pulmonary valve implantation (PPVI) in our institution. They were divided into two groups - these in whom the central pulmonary artery was used as an anchoring point for the preparation of the landing zone (n=10) for PPVI and these, in whom a pulmonary artery branch was used for this purpose (n=8). Read More

    Brom Aortoplasty for Supravalvular Aortic Stenosis.
    World J Pediatr Congenit Heart Surg 2018 Mar;9(2):139-146
    1 Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
    Background: Controversy remains regarding the optimal surgical approach for children with supravalvular aortic stenosis (SVAS).

    Methods: Since 1997 we have used Brom three-patch aortoplasty for patients with SVAS. We prefer computed tomography (CT) imaging for preoperative evaluation rather than cardiac catheterization as it avoids the well-known morbidity of general anesthesia. Read More

    Q fever in Spain: Description of a new series, and systematic review.
    PLoS Negl Trop Dis 2018 Mar 15;12(3):e0006338. Epub 2018 Mar 15.
    Department of Internal Medicine, University Teaching Hospital, Santiago de Compostela, A Coruña, Spain.
    Background: Forms of presentation of Q fever vary widely across Spain, with differences between the north and south. In the absence of reported case series from Galicia (north-west Spain), this study sought to describe a Q-fever case series in this region for the first time, and conduct a systematic review to analyse all available data on the disease in Spain.

    Methods: Patients with positive serum antibodies to Coxiella burnetii from a single institution over a 5-year period (January 2011-December 2015) were included. Read More

    Effects of Oral Flora on Platelets: Possible Consequences in Cardiovascular Disease.
    J Periodontol 1996 Oct;67 Suppl 10S:1138-1142
    Department of Oral Science.
    During episodes of dental bacteremia, viridans group streptococci encounter platelets. Among these microorganisms, certaininduce human and rabbit platelets to aggregate in vitro. In experimental rabbits, circulating streptococci induced platelets to aggregate, triggering the accumulation of platelets and fibrin into the heart valve vegetations of endocarditis. Read More

    Oral Streptococci and Cardiovascular Disease: Searching for the Platelet Aggregation-Associated Protein Gene and Mechanisms of Streptococcus sanguis-Induced Thrombosis.
    J Periodontol 2005 Nov;76 Suppl 11S:2101-2105
    Department of Oral Sciences, School of Dentistry and the Mucosal and Vaccine Research Center, University of Minnesota, Minneapolis, MN.
    Background: Pathogenic mechanisms in infective endocarditis, disseminated intravascular coagulation, and cardiovascular events involve the aggregation of platelets into thrombi. Attendant infection by oral bacteria contributes to these diseases. We have been studying how certain oral streptococci induce platelet aggregation in vitro and in vivo. Read More

    Infective Endocarditis: Current Approaches to Antibacterial Therapy.
    Antibiot Khimioter 2016;61(5-6):43-52
    The problem of infective endocarditis (IE) continues to maintain its importance because of the high mortality rate and severe complications. Modern IE is a polyetiologic disease, the onset and development of which may be due to the pathogens, components of an extremely extensive list, enlarging almost every year. The serious obstacles in the effective antimicrobial therapy refer to the growing resistance of the IE pathogens to antibiotics and the increasing etiologic role of the previously very rare infectious agents. Read More

    Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature.
    Medicine (Baltimore) 2018 Mar;97(11):e0079
    Department of Cardiology, The First Hospital of Jilin University, Changchun, China.
    Rationale: Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as "Loeffler endocarditis. Read More

    Surgical interventions of isolated active mitral valve endocarditis: Predisposing factors and impact of neurological insults on final outcome.
    Medicine (Baltimore) 2018 Mar;97(11):e0054
    Department of Thoracic and Cardiovascular Surgery.
    The feasibility and durability of mitral valve (MV) repair in active infective endocarditis (IE) has been reported, but proper management of perioperative neurological complications and surgical timing remains uncertain and may crucially affect the outcome.In this single-center retrospective observational study, patients who underwent isolated MV surgery for active native IE in our institution between August 2005 and August 2015 were reviewed and analyzed. Patients who were operated on for healed IE or who required combined procedures were excluded from this study. Read More

    Lipoteichoic Acid InhibitsBiofilm Formation.
    Front Microbiol 2018 27;9:327. Epub 2018 Feb 27.
    Department of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
    A biofilm is an aggregate of microorganisms in which cells adhere to biological or non-biological surfaces and is responsible for various infectious diseases. Infections caused by, including pneumonia, endocarditis, and osteomyelitis, are often associated with colonization and biofilm formation. Although lipoteichoic acid (LTA) is involved in biofilm formation, the specific role of LTA is not clearly understood. Read More

    A case of tricuspid valve non-bacterial thrombotic endocarditis presenting as pulmonary embolism in a patient with antiphospholipid antibody syndrome.
    BMJ Case Rep 2018 Mar 13;2018. Epub 2018 Mar 13.
    Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
    A 47-year-old woman with a medical history of Raynaud's phenomenon presented with fever, cough and shortness of breath. She was found to have left lower lobe consolidation and pleural effusion and was treated as a case of pneumonia. During the hospital course, her respiratory status worsened, and she was intubated on the third hospital day. Read More

    A successful salvage therapy with daptomycin and linezolid for right-sided infective endocarditis and septic pulmonary embolism caused by methicillin-resistant Staphylococcus aureus.
    J Infect Chemother 2018 Mar 10. Epub 2018 Mar 10.
    Department of Cardiovascular Surgery, Japanese Red Cross Narita Hospital, 90-1, Iida-chou, Narita City, Chiba, 286-8523, Japan.
    Although vancomycin administration is recommended for the treatment of infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA), it is unclear whether an alternative agent, daptomycin, can be used to treat IE with pulmonary complications. A 26-year-old female who had undergone surgical repair of a ventricular septal defect as an early teenager presented with fever, headache, and vomiting. She was admitted to our hospital and diagnosed with right-sided IE with septic pulmonary embolism caused by MRSA. Read More

    Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases.
    Microorganisms 2018 Mar 13;6(1). Epub 2018 Mar 13.
    Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
    is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains following decades of antibiotic usage. This has generated renewed interest within the scientific community in alternative therapeutic agents, such as anti-antibodies. Read More

    French national survey on infective endocarditis and the Melody™ valve in percutaneous pulmonary valve implantation.
    Arch Cardiovasc Dis 2018 Mar 9. Epub 2018 Mar 9.
    Centre de Référence Malformations Cardiaques Congénitales, Complexes-M3C, Necker Hospital for Sick Children, George-Pompidou European Hospital, Assistance Publique des Hopitaux de Paris (AP-HP), 75015 Paris, France; Université Paris-Descartes, Sorbonne-Paris Cité, 75006 Paris, France.
    Background: Percutaneous pulmonary valve implantation (PPVI) is a routine treatment for dysfunctional right ventricular outflow tract. Infective endocarditis (IE) is a major concern.

    Aim: To report French experience with the Melody™ valve (Medtronic Inc. Read More

    Synthesis, gallium labelling and characterization of P04087, a functionalized phosphatidylserine-binding peptide.
    EJNMMI Radiopharm Chem 2017 7;2(1). Epub 2017 Feb 7.
    1Nuclear Medicine Department and DHU FIRE, Bichat-Claude Bernard University Hospital, AP-HP, Paris, France.
    Background: Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis and thrombus. The hexapeptide PGDLSR was described as a selective and high affinity ligand for PS. In this work, we synthesized and evaluated a gallium labelled-PGDLSR peptide as a potential and selective radiopharmaceutical for nuclear imaging. Read More

    Methicillin-SensitiveSuppurative Thyroiditis with Thyrotoxicosis.
    Case Rep Emerg Med 2017 19;2017:4018193. Epub 2017 Dec 19.
    Department of Emergency Medicine, Rutgers Robert Wood Johnson Medical School, 1 RWJ Place, MEB 104, New Brunswick, NJ 08901, USA.
    Intravenous drug use (IVDU) can lead to numerous complications from skin abscesses to bacteremia to endocarditis. Here, we present a rare case of acute suppurative thyroiditis as a complication of IVDU, in which a 26-year-old female with a past medical history of IVDU presented to the emergency department for evaluation of a large right sided neck mass. On exam, she had signs of sepsis and thyrotoxicosis. Read More

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