102,183 results match your criteria Infective Endocarditis


Identifying missed clinical opportunities for the earlier diagnosis of HIV in Australia, a retrospective cohort data linkage study.

PLoS One 2018 6;13(12):e0208323. Epub 2018 Dec 6.

Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia.

Background: Treatment as prevention approaches for HIV require optimal HIV testing strategies to reduce undiagnosed HIV infections. In most settings, HIV testing strategies still result in unacceptably high rates of missed and late diagnoses. This study aimed to identify clinical opportunities for targeted HIV testing in persons at risk to facilitate earlier HIV diagnosis in New South Wales, Australia; and to assess the duration between the diagnosis of specific conditions and HIV diagnosis. Read More

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December 2018

A Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco- Therapy of Skin Infection.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Abuse of antibiotics and their residues in the environment result in the emergence and prevalence of drug-resistant bacteria and lead to serious health problems. Herein, a photon-controlled antibacterial platform that can efficiently kill drug-resistant bacteria and avoid the generation of new bacterial resistance was designed by encapsulating black phosphorus quantum dots (BPQDs) and pharmaceutical inside a thermal-sensitive liposome. The antibacterial platform can release pharmaceutical in a spatial-, temporal- and dosage-controlled fashion since the BPQDs can delicately generate heat under near-infrared (NIR) light stimulation to disrupt the liposome. Read More

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December 2018
2 Reads

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Pharm Res 2018 Dec 5;36(1):22. Epub 2018 Dec 5.

Department Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123, Saarbrücken, Germany.

Purpose: The objective of this work was to evaluate the potential of polymeric spherical and aspherical invasive nanocarriers, loaded with antibiotic, to access and treat intracellular bacterial infections.

Methods: Aspherical nanocarriers were prepared by stretching of spherical precursors, and both aspherical and spherical nanocarriers were surface-functionalized with the invasive protein InvA497. The relative uptake of nanocarriers into HEp-2 epithelial cells was then assessed. Read More

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December 2018
1 Read

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The radiographic appearance of infectious intracranial aneurysms (IIAs) of infective endocarditis (IE) on magnetic resonance imaging (MRI) of brain is varied. We aimed to describe the IIA-specific MRI features in a series of patients with IIAs.

Methods: Records of patients with active IE who had digital subtraction angiography (DSA) at a tertiary medical center from January 2011 to December 2016 were reviewed. Read More

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December 2018
1 Read

Preliminary Results of Bone Regeneration in Oromaxillomandibular Surgery Using Synthetic Granular Graft.

Biomed Res Int 2018 5;2018:8503427. Epub 2018 Nov 5.

Unit of Maxillo-Facial Surgery, University of Rome "Sapienza", Azienda Ospedaliera Universitaria "Sant'Andrea", Rome, Italy.

Traumatic, neoplastic, inflammatory, or infective dental removal promotes a gradual resorption process of bone which leads to a "nonuse" atrophy of the alveolar ridges. Many techniques allows restoring an appropriate bone thickness, but nowadays the attention is focused on the use of natural or synthetic grafts. Numerous studies have been conducted to develop and test new synthetic materials. Read More

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November 2018

Non-standard treatment for uncomplicated urogenital infections: a systematic review.

BMJ Open 2018 Dec 4;8(12):e023808. Epub 2018 Dec 4.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To review the literature for non-standard treatment options for uncomplicated (CT) infections in adolescents and adults.

Design: Systematic review.

Data Sources: Ovid MEDLINE/PubMed, Ovid EMBASE, Cochrane Trials & Systematic Review Databases, CINAHL Plus with Full Text, Web of Science Core Collection, Scopus, ProQuest Dissertations & Theses Global, ClinicalTrials. Read More

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December 2018

Oral vaccination with Trichinella spiralis DNase II DNA vaccine delivered by attenuated Salmonella induces a protective immunity in BALB/c mice.

Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More

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December 2018

Evaluation of anti-infectives prescriptions in a pediatric hemato-oncological center: A retrospective study.

J Oncol Pharm Pract 2018 Dec 5:1078155218816779. Epub 2018 Dec 5.

1 Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Introduction: A few years after the discovery and development of anti-infectives, this therapeutic feat gave way to bacterial resistance because of the overconsumption of antibiotics, most often with unjustified prescriptions. The objective was to evaluate the compliance of the prescription of antibiotherapy in the pediatric onco-hematology unit of Rabat Children's Hospital and to determine the drug interactions.

Material And Methods: This is a retrospective study of anti-infectives prescriptions in pediatric onco-hematology. Read More

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December 2018

Trends in Drug Use-Associated Infective Endocarditis and Heart Valve Surgery, 2007 to 2017: A Study of Statewide Discharge Data.

Ann Intern Med 2018 Dec 4. Epub 2018 Dec 4.

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (A.J.S., D.L.R.).

Background: Drug use-associated infective endocarditis (DUA-IE) is increasing as a result of the opioid epidemic. Infective endocarditis may require valve surgery, but surgical treatment of DUA-IE has invoked controversy, and the extent of its use is unknown.

Objective: To examine hospitalization trends for DUA-IE, the proportion of hospitalizations with surgery, patient characteristics, length of stay, and charges. Read More

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December 2018

Drug-Associated Infective Endocarditis Trends: What's All the Buzz About?

Authors:
Alysse G Wurcel

Ann Intern Med 2018 Dec 4. Epub 2018 Dec 4.

Tufts Medical Center and Tufts University, Boston, Massachusetts (A.G.W.).

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December 2018

Oral antibiotics in infective endocarditis.

Authors:
David Isaacs

J Paediatr Child Health 2018 Dec;54(12):1401-1402

Children's Hospital at Westmead, Sydney.

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December 2018

The Hsp70/J-protein machinery of the African trypanosome, Trypanosoma brucei.

Cell Stress Chaperones 2018 Dec 1. Epub 2018 Dec 1.

Biotechnology Innovation Centre, Rhodes University, Grahamstown, South Africa.

The etiological agent of the neglected tropical disease African trypanosomiasis, Trypanosoma brucei, possesses an expanded and diverse repertoire of heat shock proteins, which have been implicated in cytoprotection, differentiation, as well as progression and transmission of the disease. Hsp70 plays a crucial role in proteostasis, and inhibition of its interactions with co-chaperones is emerging as a potential therapeutic target for numerous diseases. In light of genome annotations and the release of the genome sequence of the human infective subspecies, an updated and current in silico overview of the Hsp70/J-protein machinery in both T. Read More

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December 2018

Pulmonary Valve Prosthesis Endocarditis Caused By .

Thorac Cardiovasc Surg Rep 2018 Jan 29;7(1):e47-e49. Epub 2018 Nov 29.

Center of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.

  is a gram-negative bacterium assigned to the family of . Less than 1% of Q-fever infection leads to infective endocarditis (IE). Cases of reported pulmonary valve (PV) prosthesis endocarditis are scarce. Read More

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January 2018

Valve durability after transcatheter aortic valve implantation.

J Thorac Dis 2018 Nov;10(Suppl 30):S3629-S3636

Division of Cardiology, University of Washington, Seattle, WA, USA.

Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure to treat severe symptomatic aortic stenosis. While the TAVI procedure can be performed safely and provide excellent 5-year results, little is known about long-term durability. TAVI valves are composed of bioprosthetic leaflets are prone to deterioration, which are categorized as structural valve deterioration (SVD) and non-SVD. Read More

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November 2018

Regulation of Root-Knot Nematode Behavior by Seed Coat Mucilage-Derived Attractants.

Mol Plant 2018 Nov 29. Epub 2018 Nov 29.

Graduate School of Science & Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan. Electronic address:

Seed exudates influence the behaviour of soil organisms, but how this occurs remains unclear, particularly for multicellular animals. Here we show that compounds associated with Arabidopsis seed coat mucilage regulate the behaviour of soil-borne animals, specifically root-knot nematodes (RKN). Infective RKN J2 larvae actively travel toward Arabidopsis seeds through chemotaxis. Read More

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November 2018
1 Read

Surgical treatment of right-sided infective endocarditis.

J Thorac Cardiovasc Surg 2018 Sep 25. Epub 2018 Sep 25.

Heart and Vascular Institute, Department of Thoracic and Cardiovascular Surgery. Electronic address:

Objective: Right-sided infective endocarditis is increasing because of increasing prevalence of predisposing conditions, and the role and outcomes of surgery are unclear. We therefore investigated the surgical outcomes for right-sided infective endocarditis.

Methods: From January 2002 to January 2015, 134 adults underwent surgery for right-sided infective endocarditis. Read More

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September 2018

Identification of novel vaccine candidates against cryptosporidiosis of neonatal bovines by reverse vaccinology.

Vet Parasitol 2018 Dec 12;264:74-78. Epub 2018 Nov 12.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Argentina; Facultad de Ciencias exactas, químicas y naturales (FCEQN), Universidad de Morón, Morón, Argentina. Electronic address:

The apicomplexan protozoan Cryptosporidium parvum is an important causative agent of diarrhea of neonatal bovines. Vaccination has been proposed as an advantageous strategy against cryptosporidiosis of calves since besides protection against disease it has also the potential to prevent dissemination of infective oocysts into the environment. Antigens anchored to the parasite surface via glycosylphosphatidylinositol (GPI) are implicated in host cell attachment and invasion and represent promising vaccine candidates. Read More

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December 2018

Establishment of Cooperia oncophora in calves.

Vet Parasitol 2018 Dec 8;264:64-68. Epub 2018 Nov 8.

AgResearch Grasslands, Private Bag 11008, Palmerston North, 4442, New Zealand.

The establishment rate of Cooperia oncophora related to host age and previous infection was investigated in young calves. Calves of similar age were kept on a feed pad and allocated into multiple groups, based on their age and weight. Two groups (each n = 16) received trickle infections with an ivermectin-susceptible C. Read More

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December 2018

Eprinomectin pour-on: Prevention of gastrointestinal and pulmonary nematode infections in sheep.

Vet Parasitol 2018 Dec 8;264:42-46. Epub 2018 Nov 8.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101 Rohrdorf, Germany.

The present study was conducted to further characterize the anthelmintic activity of the 0.5% w/v topical formulation of eprinomectin (EPRINEX Pour-on, Merial) when administered at 1 mg/kg body weight to sheep in preventing the establishment of induced gastrointestinal and pulmonary nematode infections. Thirty-six female Merino sheep (∼4 months of age, weighing 27. Read More

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December 2018

[Antibiotic prophylaxis in urodynamics: Clinical practice guidelines using a formal consensus method].

Prog Urol 2018 Nov 27. Epub 2018 Nov 27.

Service d'urologie, université Paris-7, hôpital Bichat Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.

Objective: The aim of this work was to issue clinical practice guidelines on antibiotic prophylaxis in urodynamics (urodynamic studies, UDS).

Materials And Methods: Clinical practice guidelines were provided using a formal consensus method. Guidelines proposals were drew up by a multidisciplinary experts group (pilot group = steering group), then rated by a panel of 12 experts (rating group) using a formal consensus method, and then peer reviewed by a reviewing/reading group of experts (different from the rating group). Read More

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November 2018
4 Reads

A Nationwide Study in Denmark of the Association Between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents.

JAMA Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Importance: Infections have been associated with increased risks for mental disorders, such as schizophrenia and depression. However, the association between all infections requiring treatment and the wide range of mental disorders is unknown to date.

Objective: To investigate the association between all treated infections since birth and the subsequent risk of development of any treated mental disorder during childhood and adolescence. Read More

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December 2018

Syphilitic uveitis misdiagnosed as viral retinitis-a misleading history.

J Ophthalmic Inflamm Infect 2018 Dec 4;8(1):22. Epub 2018 Dec 4.

Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi, 110001, India.

Background: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision.

Findings: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. Read More

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December 2018
3 Reads

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.

Parasit Vectors 2018 Dec 4;11(1):622. Epub 2018 Dec 4.

Department of Parasitology, Faculty of Science, University of Granada, Granada, Spain.

Background: Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. In this study, we examine the potential functions of two proteins of Leishmania major, PHB1 and PHB2, as well as how they might help protect the protozoan against oxidative stress. Read More

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December 2018

Patient preferences for treatment of acute bacterial skin and skin structure infections in the emergency department.

BMC Health Serv Res 2018 Dec 4;18(1):932. Epub 2018 Dec 4.

Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.

Background: Limited research has assessed patient preferences for treatment disposition and antibiotic therapy of acute bacterial skin and skin structure infection (ABSSSI) in the emergency department (ED). Understanding patient preference for the treatment of ABSSSI may influence treatment selection and improve satisfaction.

Methods: A survey was conducted across 6 US hospital EDs. Read More

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December 2018
1 Read

Antimicrobial Susceptibilities of Oral Isolates of and According to the Consensus Guidelines for Fastidious Bacteria.

Medicines (Basel) 2018 Dec 3;5(4). Epub 2018 Dec 3.

Department of Microbiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan.

The genera and , previously known as nutritionally variant streptococci (NVS), are fastidious bacteria requiring vitamin B₆ analogs for growth. They are members of human normal oral microbiota, and are supposed to be one of the important pathogens for so-called "culture-negative" endocarditis. The type strains and oral isolates identified, by using both phenotypic profiles and the DNA⁻DNA hybridization method, were examined for susceptibilities to 15 antimicrobial agents including penicillin (benzylpenicillin, ampicillin, amoxicillin, and piperacillin), cephem (cefazolin, ceftazidime, ceftriaxone, and cefaclor), carbapenem (imipenem), aminoglycoside (gentamicin), macrolide (erythromycin), quinolone (ciprofloxacin), tetracycline (minocycline), glycopeptide (vancomycin), and trimethoprim-sulfamethoxazole complex. Read More

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December 2018

Impact of tetracationic calix[4]arene conformation - from conic structure to expanded bolaform- on their antibacterial and antimycobacterial activities.

Chembiochem 2018 Dec 4. Epub 2018 Dec 4.

FRANCE.

The four possible conformers of a new tetra-guanidino calix[4]arene thought to interact deleteriously with bacterial membrane were synthesized, characterized and evaluated for their in vitro antibacterial activity against various reference Gram negative and Gram positive bacteria: E. coli, P. aeruginosa, S. Read More

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December 2018
1 Read
3.090 Impact Factor

[S2k guidelines of the PEG on calculated parenteral initial treatment of bacterial diseases in adults : Focussed summary and supplementary information on antibiotic treatment of critically ill patients].

Anaesthesist 2018 Dec 3. Epub 2018 Dec 3.

Stabsstelle Klinische Mikrobiologie und Krankenhaushygiene, Klinikum der Universität München, Campus Großhadern, München, Deutschland.

In January 2018 the recent revision of the S2k guidelines on calculated parenteral initial treatment of bacterial diseases in adults-update 2018 (Editor: Paul Ehrlich Society for Chemotherapy, PEG) was realized. It is a helpful tool for the complex infectious disease setting in an intensive care unit. The present summary of the guidelines focuses on the topics of anti-infective agents, including new substances, pharmacokinetics and pharmacodynamics as well as on microbiology, resistance development and recommendations for calculated drug therapy in septic patients. Read More

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December 2018
2 Reads

Mutations in and Correlate With Daptomycin Resistance in .

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, TX

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (/ sub-group) from daptomycin (DAP)-naïve patients to develop DAP resistance All strains rapidly developed high-level and stable DAP-resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified: CdsA (phosphatidate cytidylyltransferase) and/or PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. Read More

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December 2018
1 Read

Is One Sample Enough? β-lactam Target Attainment and Penetration into Epithelial Lining Fluid based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA

Describing the disposition of antimicrobials agents at the site of infection is crucial to guide optimal dosing for investigational agents. For antibiotics in development for nosocomial pneumonia, concentrations are frequently determined in the epithelial lining fluid (ELF) of the lung from a bronchoscopy at a single time point. The influence of profiles constructed from a single ELF concentration point for each subject has never been reported. Read More

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December 2018

Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report.

J Med Case Rep 2018 Dec 3;12(1):357. Epub 2018 Dec 3.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 301B Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong SAR.

Background: Limbic encephalitis is characterized by rapid onset of working memory deficit, mood changes, and often seizures. The condition has a strong paraneoplastic association, but not all cases are invariably due to tumors.

Case Presentation: We present a case of limbic encephalitis in a Chinese patient who initially presented to our hospital with optic neuritis and no other neurological symptoms. Read More

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December 2018

Infective endocarditis complicated with nonobstructive ST elevation myocardial infarction related to septic embolism with intracranial hemorrhage: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13089

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital.

Rationale: Infective endocarditis (IE) complicated with obstructive ST elevation myocardial infarction (STEMI) has been reported in the literature and which were mostly related to coronary artery embolism, obstruction, or compression. However, there has been no reported case discussing about IE complicated with nonobstructive STEMI.

Patient Concerns: In this report, we report a 38-year-old female suffering from intermittent fever and was later diagnosed as IE. Read More

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November 2018
1 Read

Difference in Outcome Following Surgery for Native Aortic and Mitral Valve Infective Endocarditis.

Thorac Cardiovasc Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Skane University Hospital and Lund University, Lund, Sweden.

Background:  We investigated differences in clinical presentation, microbiology, and short- and long-term results according to the affected valve in patients who underwent surgery for left-sided native valve infective endocarditis (IE).

Methods:  This was a single-center retrospective study of 117 patients with isolated mitral valve IE (group M) and 140 patients with isolated aortic valve IE (group A) who underwent surgery between 1998 and 2015.

Results:  The mean age of patients in group M was 62 ± 14 years, whereas in group A the patients were 56 ± 14 years old ( = 0. Read More

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November 2018
7 Reads

A metapopulation model of dog rabies transmission in N'Djamena, Chad.

J Theor Biol 2018 Nov 27;462:408-417. Epub 2018 Nov 27.

Swiss Tropical and Public Health Institue, Socinstrasse 57, Basel 4051, Switzerland; University of Basel, Petersplatz 1, Basel 4001, Switzerland.

Rabies transmission was interrupted for several months in N'Djamena, the capital city of Chad, after two mass vaccination campaigns of dogs. However, there was a resurgence in cases, which was not predicted by previous models of rabies transmission. We developed a deterministic metapopulation model with importation of latent dogs, calibrated to four years of weekly incidence data from passive surveillance, to investigate possible causes for the early resurgence. Read More

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November 2018

Exploring the biology and structural architecture of sortase roleon Biofilm formation in gram positive pathogens.

Curr Top Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Science Block, Karaikudi-630003, Tamilnadu. India.

Gram-positive bacteria signify a surface organelle that decorates the cell surfaces using Sortase enzymes. The mechanism of SrtC lings to the formation of amide or peptide bonds between cell surface proteins that sorting signal to strategically positioned amino groups. Sorting signals linked to peptidoglycan function as the principal architects of cell wall and facilitate each microbe to effectively interact with its host environment. Read More

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November 2018

Enterocutaneous fistula in severely active Crohn's disease: preoperative anti-TNF alpha treatment to limit bowel resection-report of a case.

Int J Colorectal Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.

Purpose: Strategies for limiting the extent of bowel resection in cases of enterocutaneous or interenteric fistulas in severely active Crohn's disease are urgently necessary. Anti-inflammatory therapy with tumor necrosis factor alpha (anti-TNF alpha) inhibitors has positive impact on fistulizing Crohn's disease. We describe a case of a 32-year-old male suffering from enterocutaneous fistula in severely active Crohn's disease. Read More

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November 2018
3 Reads

Multispacer sequence typing of Coxiella burnetii DNA from removed prosthetic heart valve material discloses first human case of infective endocarditis caused by MST_18.

Int J Infect Dis 2018 Nov 26. Epub 2018 Nov 26.

Department of Clinical Microbiology, Aarhus University Hospital,Palle-Juul Jensens Boulevard 99, DK-8200 Aarhus N.

Introduction: In Denmark, Q fever was previously considered a rare and imported disease, but recent testing of antibodies in cattle as well as humans has indicated that the infection is widespread. A 76-year old Danish man was diagnosed with infective endocarditis and underwent open surgical aortic valve replacement with insertion of a biologic valve. Due to paravalvular leakage, destruction of the aortic annulus, and an aortic root abscess, the patient was re-operated three weeks later with replacement of the biologic valve and insertion of an aortic prosthetic tube. Read More

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November 2018
1 Read

Cardiac Computed Tomography of Aortic Infective Endocarditis.

QJM 2018 Nov 28. Epub 2018 Nov 28.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, Japan.

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November 2018

Bilateral watershed infarcts in infective endocarditis.

QJM 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Geriatrics, Ng Teng Fong General Hospital, Singapore.

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November 2018
1 Read

Musculoskeletal manifestations in pediatric patients infected with human immunodeficiency virus: Developing country perspective.

Eur J Rheumatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Medicine, Kolkata Medical College, Kolkata, India.

Objective: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established.

Methods: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years. Read More

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October 2018

Autophagy: A necessary process during the Trypanosoma cruzi life-cycle.

Virulence 2018 Nov 29:1-10. Epub 2018 Nov 29.

a Laboratorio de Biología de Trypanosoma cruzi y la célula hospedadora, Instituto de Histología y Embriología (IHEM) "Dr. Mario H. Burgos" CONICET , Universidad Nacional de Cuyo , Mendoza , Argentina.

Autophagy is a well-conserved process of self-digestion of intracellular components. T. cruzi is a protozoan parasite with a complex life-cycle that involves insect vectors and mammalian hosts. Read More

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November 2018
5 Reads

Staphylococcus aureus endocarditis associated with injecting new psychoactive substances.

J R Coll Physicians Edinb 2018 Dec;48(4):304-310

Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Staphylococcus aureus infective endocarditis (IE) associated with injection of new psychoactive substances (NPS) in Edinburgh from 2014 to 2016 was observed. We compared these infections with a series of S. aureus IE cases in a non-injecting population within Edinburgh. Read More

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December 2018
2 Reads

Infective Endocarditis in the Elderly: Diagnostic and Treatment Options.

Drugs Aging 2018 Nov 29. Epub 2018 Nov 29.

Department of Cardiology, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Infective endocarditis (IE) is an uncommon, life-threatening systemic disorder with significant morbidity and persistently high mortality. The age of the peak incidence of IE has shifted from 45 years in the 1950s to 70 years at the present time, and elderly people have a five-fold higher risk of IE than the general adult population. Elderly IE patients demonstrate a higher prevalence of coagulase-negative staphylococci, enterococci and Streptococcus bovis, and lower rates of infection by viridans group streptococci. Read More

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November 2018
1 Read

Evaluation of Strategies in the Management of Infective Aortic Valve Endocarditis at German Cardiac Surgical Departments.

Thorac Cardiovasc Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, Germany.

Background:  Surgical treatment of infective aortic valve endocarditis (AVE) remains a therapeutic challenge, necessitating interdisciplinary approach to limit morbidity and mortality in this high-risk cohort. With a considerable spectrum of available laboratory testings, imaging techniques, as well as operative strategies developed in recent years, there is a lack of standardization across cardiac surgical departments in Germany. Thus, the optimal treatment strategy of AVE has yet to be defined. Read More

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November 2018

Stroke in Patients with Infective Endocarditis: A 15-Year Single-Center Cohort Study.

Eur Neurol 2018 Nov 28;80(3-4):171-178. Epub 2018 Nov 28.

Department of Neurology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: To explore the relationship between infective endocarditis (IE) and stroke.

Methods: The clinical data of patients diagnosed with IE from January 2003 to December 2017 in Beijing Anzhen Hospital Affiliated to Capital Medical University were retrospectively analyzed.

Results: A total of 861 patients (mean age: 40. Read More

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November 2018
2 Reads

Early surgery with aggressive surgical approach to improve 6-month outcomes in patients with active infective endocarditis: contribution of cerebral preoperative magnetic resonance imaging.

Gen Thorac Cardiovasc Surg 2018 Nov 27. Epub 2018 Nov 27.

Departments of Cardiology, Sapporo City General Hospital, Sapporo, Japan.

Objectives: We investigated the hypothesis that early surgery for infective endocarditis (IE) attenuates the rate of death or embolic events and does not increase the rate of relapse or postoperative valvular dysfunction (PVD) at 6 months.

Methods: 21 consecutive patients who underwent surgical treatment of IE were prospectively included. We assessed 6-month postoperative clinical outcomes by comparing early surgery (Group E, surgery within 72 h) and conventional treatment (Group C). Read More

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November 2018

Asunaprevir and daclatasvir in hemodialysis patients with chronic hepatitis C virus genotype 1b infection.

JGH Open 2017 Dec 28;1(4):148-152. Epub 2017 Nov 28.

Department of Internal Medicine, Division of Hepatology Saga University Hospital Saga Japan.

Background And Aim: Patients requiring hemodialysis show high morbidity with hepatitis C virus (HCV) infection, but there are difficulties associated with interferon-based therapies. Asunaprevir and daclatasvir could help patients with HCV genotype 1b because the drugs have a nonrenal metabolism and show good viral eradication. We evaluated the efficacy and safety of combined asunaprevir and daclatasvir therapy. Read More

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December 2017

Severity of presentation, not sex, increases risk of surgery for infective endocarditis (Commentary).

Ann Thorac Surg 2018 Nov 24. Epub 2018 Nov 24.

Structural Heart and Valve Center, Division of Cardiovascular Surgery, Emory University School of Medicine, 550 Peachtree Street NE, 6(th) Floor Atlanta, GA 30308. Electronic address:

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November 2018
1 Read

Innate Immune and Fungal Model of Alzheimer's Disease.

Authors:
Bodo Parady

J Alzheimers Dis Rep 2018 Aug 1;2(1):139-152. Epub 2018 Aug 1.

Children's Hospital Oakland Research Institute, Oakland, CA, USA.

Various fungi and bacteria can colonize in the brain and produce physical alterations seen in Alzheimer's disease (AD). Environmental and genetic factors affect the occurrence of fungal colonization, and how fungi can grow, enter the brain, and interact with the innate immune system. The essence of AD development is the defeat of the innate immune system, whether through vulnerable patient health status or treatment that suppresses inflammation by suppressing the innate immune system. Read More

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August 2018
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Diffusion-weighted Magnetic Resonance Imaging in Non-traumatic Vertebral Collapse: A Relook Into Its Utility in Making the Diagnosis in a Population Where Infections of Spine Are a Common Cause.

J Med Imaging Radiat Sci 2018 Mar 16;49(1):90-96. Epub 2017 Oct 16.

Department of Orthopaedics, JNMCH, AMU, Aligarh, Uttar Pradesh, India.

Aim: Magnetic resonance imaging (MRI) is the imaging investigation of choice in vertebral collapse. In this study, we considered various MRI features and appearance based on morphological features, signal intensity, contrast enhancement characteristics, and diffusion-weighted imaging (DWI) of various types of non-traumatic vertebral collapse for differentiating benign from malignant causes and its role in differentiating cases of infectious causes of vertebral collapse from malignant causes.

Materials And Methods: Between November 2014 to November 2016 a total of 100 consecutive patients from the MRI centre of JN Medical College and Hospital, Aligarh, were evaluated for the study. Read More

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Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2018 Nov 26. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

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November 2018
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