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    20794 results match your criteria Infectious Myositis

    1 OF 416

    Acute myositis: an unusual and severe side effect of docetaxel: a case report and literature review.
    Anticancer Drugs 2018 Mar 20. Epub 2018 Mar 20.
    Departments of Medical Oncology.
    Docetaxel is an antimicrotubules cytotoxic agent prescribed widely by medical oncologists in multiple tumor types (breast, lung, prostate, stomach, head, and neck). However, the side effects of docetaxel are numerous (cytopenia, peripheral edema, myalgia, arthralgia, alopecia, and sensitive neuropathy) and recent concerns have been raised about neutropenic enterocolitis in France. Here, we report the case of a 57-year-old patient with metastatic prostatic cancer, who developed a severe myositis and fasciitis grade IV 1 week after his second docetaxel infusion. Read More

    Type I interferon in rheumatic diseases.
    Nat Rev Rheumatol 2018 Mar;14(4):214-228
    Colton Center for Autoimmunity, Department of Medicine, New York University School of Medicine, New York, NY, USA.
    The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases, large subgroups of patients demonstrate persistent activation of the type I interferon pathway. Genetic variations in type I interferon-related genes are risk factors for some rheumatic diseases, and can explain some of the heterogeneity in type I interferon responses seen between patients within a given disease. Read More

    [Serum free light chains for monitoring systemic lupus erythematosus activity].
    Wiad Lek 2018 ;71(1 pt 1):21-31
    Klinika Reumatologii i Układowych Chorób Tkanki Łącznej Uniwersytetu Medycznego w Lublinie, Lublin, Polska.
    Objective: Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease leading to chronic inflammation of numerous tissues and organs. The search for clinically useful markers of its activity is ongoing. At present, it is suggested that serum free light chains (FLC) may be useful in assessing SLE activity. Read More

    Case Series: Herpes Zoster Ophthalmicus with Acute Orbital Inflammation.
    Optom Vis Sci 2018 Mar 16. Epub 2018 Mar 16.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
    Significance: Herpes zoster ophthalmicus (HZO) has variable initial manifestations, and acute orbital inflammation may be the first sign without apparent zoster rash. This case series is significant for presenting diverse clinical features and treatment options of HZO with acute orbital inflammation.

    Purpose: To report a case series of patients diagnosed as HZO with acute orbital inflammation including two cases with unique presentations. Read More

    New Myositis Classification Criteria-What We Have Learned Since Bohan and Peter.
    Curr Rheumatol Rep 2018 Mar 17;20(4):18. Epub 2018 Mar 17.
    Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Rheumatology Unit, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
    Purpose Of Review: Idiopathic inflammatory myopathy (IIM) classification criteria have been a subject of debate for many decades. Despite several limitations, the Bohan and Peter criteria are still widely used. The aim of this review is to discuss the evolution of IIM classification criteria. Read More

    Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion.
    Mol Neurobiol 2018 Mar 15. Epub 2018 Mar 15.
    German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.
    Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disorder in the elderly with no defined etiology or effective therapy. Endoplasmic reticulum stress and deposition of myostatin, a secreted negative regulator of muscle growth, have been implicated in disease pathology. The myostatin signaling pathway has emerged as a major target for symptomatic treatment of muscle atrophy. Read More

    The prevalence and clinical significance of anti-PUF60 antibodies in patients with idiopathic inflammatory myopathy.
    Clin Rheumatol 2018 Mar 15. Epub 2018 Mar 15.
    Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, Beijing, 100029, China.
    Autoantibodies against poly-U-binding factor 60 kDa protein (PUF60) have been reported in Caucasian dermatomyositis (DM) patients. However, their clinical significance in idiopathic inflammatory myopathy (IIM) remains to be fully clarified. Our objective was to analyze the prevalence and clinical significance of anti-PUF60 antibodies in a large cohort of Chinese IIM patients. Read More

    Bench to bedside review of myositis autoantibodies.
    Clin Mol Allergy 2018 7;16. Epub 2018 Mar 7.
    Experimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. Read More

    Using serum troponins to screen for cardiac involvement and assess disease activity in the idiopathic inflammatory myopathies.
    Rheumatology (Oxford) 2018 Mar 12. Epub 2018 Mar 12.
    Rheumatology Department, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
    Objectives: Limitations in the methods available for identifying cardiac involvement and accurately quantifying disease activity in the idiopathic inflammatory myopathies (IIMs) may contribute to poor outcomes. We investigated the utility of different serum muscle damage markers [total creatine kinase (CK), cardiac troponin T (cTnT) and cardiac troponin I (cTnI)] to address these issues.

    Methods: We assessed disease activity and cardiac involvement using the International Myositis Assessment and Clinical Studies Group core set measures in 123 participants with confirmed adult-onset IIM from the UK and Denmark. Read More

    β2-microglobulin as a marker of systemic lupus erythematosus activity.
    Adv Clin Exp Med 2018 Mar 13. Epub 2018 Mar 13.
    Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland.
    Background: Systemic lupus erythematosus (SLE) is characterized by alternating periods of activity and remission. A portion of the patients suffers from the chronically active form of the disease. The search for clinically useful markers of its activity is ongoing. Read More

    Myositis-specific autoantibodies in Japanese patients with juvenile idiopathic inflammatory myopathies.
    Mod Rheumatol 2018 Mar 13:1-16. Epub 2018 Mar 13.
    a Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.
    Objectives: The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs).

    Methods: We retrospectively analyzed the frequency of MSAs and their association with clinical or laboratory findings in 25 Japanese patients with JIIMs in Hokkaido district.

    Results: Eighteen of 25 patients (72%) were positive for MSAs; seven with anti-melanoma differentiation associated gene (MDA) 5 (28%), 5 with anti-transcriptional intermediary factor (TIF)-1γ (20%), 4 with anti-MJ/nuclear matrix protein (NXP)-2 (16%), 2 with anti-Jo-1 (8%), 1 with anti- HMG-CoA reductase, 1 with anti-signal recognition peptide (SRP) antibodies (4% each), including co-existence and transition of MSAs in one patient each. Read More

    Prevalence of Myositis-Specific Antibodies in Idiopathic Interstitial Pneumonias.
    Lung 2018 Mar 12. Epub 2018 Mar 12.
    Department of Pneumology, University Hospitals Leuven (UZ Leuven), Herestraat 49, 3000, Louvain, Belgium.
    Although included in the serological domain of the 'interstitial pneumonia with auto-immune features' (IPAF) research statement, the search for myositis-specific antibodies (MSA) is not incorporated in routine clinical practice. The objective of the study was to evaluate MSA prevalence in an idiopathic interstitial pneumonia (IIP) cohort (n = 68) with suggestive morphological interstitial lung disease patterns. Twelve of 68 patients (17. Read More

    Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease.
    BMC Pulm Med 2018 Mar 12;18(1):44. Epub 2018 Mar 12.
    Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
    Background: Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal role. Neutrophils store azurophil granules that contain defensins, which are antimicrobial peptides that regulate the inflammatory response. Read More

    Anti-PL-7 Antisynthetase Syndrome with Eosinophilic Pleural Effusion.
    Intern Med 2018 Mar 9. Epub 2018 Mar 9.
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan.
    A 68-year-old woman was admitted to our hospital with fever and pleural effusion. Her thoracentesis showed eosinophilic pleural effusion (EPE) without any evidence of malignancy, infection, or trauma. Pleural biopsy revealed pleuritis and intercostal myositis. Read More

    Skeletal muscle cells actively shape (auto)immune responses.
    Autoimmun Rev 2018 Mar 9. Epub 2018 Mar 9.
    Department of Neurology, University of Münster, Germany. Electronic address:
    Histopathological analyses of muscle specimens from myositis patients indicate that skeletal muscle cells play an active role in the interaction with immune cells. Research over the last few decades has shown that skeletal muscle cells exhibit immunobiological properties that perfectly define them as non-professional antigen presenting cells. They are able to present antigens via major histocompatibility complex molecules, exhibit costimulatory molecules and secrete soluble molecules that actively shape the immune response in an either pro- or anti-inflammatory manner. Read More

    Perspective: Scientific and ethical concerns pertaining to animal models of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA).
    Autoimmun Rev 2018 Mar 8. Epub 2018 Mar 8.
    Victorian Cytology Service, Carlton, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Australia.
    The autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was first described in 2011. The aluminium containing adjuvants of vaccines were stated to be one of the main causes of the condition. Other disorders associated with ASIA include siliconosis, Gulf war syndrome, sick building syndrome and the macrophagic myositis syndrome. Read More

    Revisiting Pathological Classification Criteria for Adult Idiopathic Inflammatory Myopathies: In-Depth Analysis of Muscle Biopsies and Correlation Between Pathological Diagnosis and Clinical Manifestations.
    J Neuropathol Exp Neurol 2018 Mar 7. Epub 2018 Mar 7.
    Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
    The European Neuromuscular Centre (ENMC) pathological classification criteria of idiopathic inflammatory myopathies (IIMs) are debatable. The aim of this study was to explore their practicability and reproducibility. We conducted a retrospective analysis of 57 cases of IIMs excluding dermatomyositis (DM) and sporadic inclusion body myositis (sIBM) by in-depth analysis of muscle biopsies and comparisons of the clinical characteristics among polymyositis (PM), non-specific myositis (NSM) and necrotizing autoimmune myopathy (NAM). Read More

    Recognition and nursing management of children with non-traumatic limp.
    Emerg Nurse 2018 03;25(10):24-30
    Torbay Hospital, Torquay, Devon, England.
    Children with acute onset non-traumatic limp often present to emergency departments (EDs). The limp can occasionally be associated with medical emergencies such as septic arthritis and slipped upper femoral epiphysis but is often due to less severe conditions. This article discusses the common and self-limiting causes of acute onset of non-traumatic limp in children, such as transient synovitis, reactive arthritis, and benign acute childhood myositis. Read More

    Cytological and histological correlation of granular cell tumor in a series of three cases.
    J Cancer Res Ther 2018 Jan-Mar;14(2):459-461
    Department of Pathology, IPGME and R, Kolkata, West Bengal, India.
    Granular cell tumor (GCT) is an uncommon soft tissue tumor characterized by proliferation of cells with granular eosinophilic cytoplasm. We came across three such tumors, one in the tongue, one in the chest wall, and one in the right deltoid region, which were referred for fine-needle aspiration cytology. On cytological examination, the first two cases were diagnosed as GCT, and the mass in deltoid region was suggestive of proliferative myositis. Read More

    Serum BAFF in Indian patients with IIM: a retrospective study reveals novel clinico-phenotypic associations in children and adults.
    Clin Rheumatol 2018 Mar 7. Epub 2018 Mar 7.
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.
    We studied the serum levels of B cell survival factors BAFF and APRIL in patients with idiopathic inflammatory myositis (IIM) and their relation with clinical and autoantibodies. Seventy-five patients (51 females and 24 males) with IIM (Bohan and Peter's criteria 1975) and 25 healthy adults were analyzed for BAFF, APRIL and IL-17 by ELISA, and myositis-specific and associated antibodies (MSA and MAA) using line immunoblot assay. Of the 75 patients, 59 were adults, 42 had Dermatomyositis (DM), and 17 had Polymyositis. Read More

    Myositis, Ganglioneuritis, and Myocarditis with Distinct Perifascicular Muscle Atrophy in a 2-Year-Old Male Boxer.
    Front Vet Sci 2018 20;5:20. Epub 2018 Feb 20.
    Comparative Neuromuscular Laboratory, Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
    A 2-year-old male, intact Boxer was referred for chronic diarrhea, hyporexia, labored breathing, weakness and elevated creatine kinase, and alanine aminotransferase activities. Initial examination and diagnostics revealed a peripheral nervous system neurolocalization, atrial premature complexes, and generalized megaesophagus. Progressive worsening of the dog's condition was noted after 36 h; the dog developed aspiration pneumonia, was febrile and oxygen dependent. Read More

    Localization and Expression of Nuclear Factor of Activated T-Cells 5 in Myoblasts Exposed to Pro-inflammatory Cytokines or Hyperosmolar Stress and in Biopsies from Myositis Patients.
    Front Physiol 2018 21;9:126. Epub 2018 Feb 21.
    Department of Neurology, Ghent University and Ghent University Hospital, Ghent, Belgium.
    Regeneration in skeletal muscle relies on regulated myoblast migration and differentiation, in which the transcription factor nuclear factor of activated T-cells 5 (NFAT5) participates. Impaired muscle regeneration and chronic inflammation are prevalent in myositis. Little is known about the impact of inflammation on NFAT5 localization and expression in this group of diseases. Read More

    Comments on the "2017 Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups". Points of concern.
    Arthritis Rheumatol 2018 Mar 7. Epub 2018 Mar 7.
    University of Cantabria, Rheumatology Division and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, CP, 39008, Santander, Spain.
    We have read with interest the report on the 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups" by Lundberg et al (1,2). These criteria represent an important advance in the classification of adult and juvenile idiopathic inflammatory myositis (IIMs), allowing the classification of IIMs in definite (probability cutoff ≥90%), probable (probability ≥55%), possible (probability ≥50% but <55%) and improbable/disposable (probability <50%), depending on the score reached by adding the selected variables (1,2). This article is protected by copyright. Read More

    Response to Comments on the "2017 EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups". Points of concern.
    Arthritis Rheumatol 2018 Mar 7. Epub 2018 Mar 7.
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    We have with great interest read the letter titled "Comments on the "2017 EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups". Points of concern", by Dr Castañeda et al published in your journal [1]. The authors discuss the antisynthetase syndrome (ASSD), a condition characterized by myositis, arthritis, interstitial lung disease (ILD), Raynaud's phenomenon and the presence of autoantibodies targeting aminoacyl transfer RNA synthetases, and the fact that this group was not included in the 2017 EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups [2]. Read More

    A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.
    Skelet Muscle 2018 Mar 6;8(1). Epub 2018 Mar 6.
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, 48824, USA.
    Background: The cause of immune-mediated myositis (IMM), characterized by recurrent, rapid-onset muscle atrophy in Quarter Horses (QH), is unknown. The histopathologic hallmark of IMM is lymphocytic infiltration of myofibers. The purpose of this study was to identify putative functional variants associated with equine IMM. Read More

    Sarcocystis myopathy in a patient with HIV-AIDS.
    J Neurovirol 2018 Mar 5. Epub 2018 Mar 5.
    Department of Medicine (Neurology), HMRC 611, University of Alberta, Edmonton, AB, T6G 2G3, Canada.
    Sarcocystosis is a zoonotic infection that causes intestinal and muscular illnesses in humans. Sarcocystosis was until recently considered rare in humans. To complete their life cycle, Sarcocystis species require both a definitive and an intermediate host. Read More

    High prevalence of chigger mite infection in a forest-specialist frog with evidence of parasite-related granulomatous myositis.
    Parasitol Res 2018 Mar 3. Epub 2018 Mar 3.
    Centro de Investigación para la Sustentabilidad and Programa de Doctorado en Medicina de la Conservación, Facultad de Ciencias de la Vida, Universidad Andres Bello, República 252, Santiago, Chile.
    Amphibians are hosts for a wide variety of micro- and macro-parasites. Chigger mites from the Hannemania genus are known to infect a wide variety of amphibian species across the Americas. In Chile, three species (H. Read More

    Laboratory investigation into the role of largemouth bass virus (Ranavirus, Iridoviridae) in smallmouth bass mortality events in Pennsylvania rivers.
    BMC Vet Res 2018 Mar 2;14(1):62. Epub 2018 Mar 2.
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 1129 Farm Lane, Room 174, East Lansing, MI, 48824, USA.
    Background: Mortality episodes have affected young-of-year smallmouth bass (Micropterus dolomieu) in several river systems in Pennsylvania since 2005. A series of laboratory experiments were performed to determine the potential role of largemouth bass virus (Ranavirus, Iridoviridae) in causing these events.

    Results: Juvenile smallmouth bass experimentally infected with the largemouth bass virus exhibited internal and external clinical signs and mortality consistent with those observed during die-offs. Read More

    Statin-related myopathies.
    Pract Neurol 2018 Mar 1. Epub 2018 Mar 1.
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
    Statins are the Marmite ('You either love it or hate it!') of the drug world, both in terms of therapeutic benefit and risk of side effects. Proponents think that they are potential life-savers, opponents that their main benefit is lining the pockets of pharma. Some consider side effects to be a major issue, outweighing any therapeutic benefit, others that they are rare and essentially innocuous. Read More

    [Statin-associated muscle symptoms : Current management in 2018].
    Rev Med Suisse 2018 Feb;14(596):462-469
    Consultation spécialisée des lipides, Service d'endocrinologie, diabétologie et métabolisme, CHUV, Avenue de la Sallaz 8, 1011 Lausanne.
    Statins are the first line treatment in hyperlipidemia, either in primary or secondary prevention of cardiovascular diseases. One of the most prescribed drug class worldwide, this drug class is often the focus of highly publicized drug controversies. Various adverse effects have been attributed to statins, in particular statin-associated muscle symptoms (SAMS). Read More

    Concurrent methicillin-resistant Staphylococcus aureus septicemia and pyomyositis in a patient with dengue hemorrhagic fever: a case report.
    BMC Infect Dis 2018 02 27;18(1):99. Epub 2018 Feb 27.
    The Teaching (General) Hospital - Kandy, Kandy, Sri Lanka.
    Background: Concurrent presence of dengue hemorrhagic fever (DHF), tropical pyomyositis and septicemia due to methicillin-resistant Staphylococcus aureus (MRSA) in a previously healthy person has never been reported. These three conditions even individually are potentially fatal. "Here we describe a case of a patient contracting dengue and developing DHF along with concurrent pyomyositis likely to be due to MRSA, leading to MRSA septicemia with abscesses formed by MRSA". Read More

    Electromyographic findings in sporadic inclusion body myositis.
    J Electromyogr Kinesiol 2018 Apr 11;39:114-119. Epub 2018 Feb 11.
    Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Clinically oriented diagnostic criteria can be as specific for diagnosis of sporadic inclusion body myositis (sIBM) as pathological criteria, especially at the time of presentation. EMG may provide an convincing proof that a muscle biopsy should be performed.

    Aims: To compare the EMG results in patients with sIBM divided into subgroups based on the newest ENMC criteria for sIBM and to obtain the utility of EMG in the diagnostic process at the time of presentation. Read More

    Evidence supports blind screening for internal malignancy in dermatomyositis: Data from 2 large US dermatology cohorts.
    Medicine (Baltimore) 2018 Jan;97(2):e9639
    Department of Dermatology, Stanford University.
    The association between dermatomyositis and internal malignancy is well established, but there is little consensus about the methods of cancer screening that should be utilized.We wished to analyze the prevalence and yield of selected cancer screening modalities in patients with dermatomyositis.We performed a retrospective analysis of 2 large US dermatomyositis cohorts comprising 400 patients. Read More

    Anti-HMGCR Myopathy.
    J Neuromuscul Dis 2018 ;5(1):11-20
    National Institutes of Health, NIAMS, Bethesda, MD, USA.
    Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spectrum of this disease to include pediatric patients and young adults without statin exposure and those with a chronic myopathy resembling limb-girdle muscular dystrophy. We provide a summary of clinical findings, pathologic features, muscle imaging, and immunogenetic risk factors of the disease. Read More

    Muscle ischaemia associated with NXP2 autoantibodies: a severe subtype of juvenile dermatomyositis.
    Rheumatology (Oxford) 2018 Feb 20. Epub 2018 Feb 20.
    Reference Center for Neuromuscular Diseases, FILNEMUS, Paris, France.
    Objectives: Myositis-specific autoantibodies (MSAs) are increasingly used to delineate distinct subgroups of JDM. The aim of our study was to explore without a priori hypotheses whether MSAs are associated with distinct clinical-pathological changes and severity in a monocentric JDM cohort.

    Methods: Clinical, biological and histological findings from 23 JDM patients were assessed. Read More

    Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations.
    Expert Rev Clin Immunol 2018 Mar 23;14(3):215-224. Epub 2018 Feb 23.
    e Internal Medicine Department, Hospital Clinic , Universitat de Barcelona , CIBERER , Barcelona , Spain.
    Introduction: Musculoskeletal manifestations are well-recognized side effects of treatment with statins. New advances in this field have appeared in recent years. This review focuses on the diagnosis of these conditions and their underlying pathogenesis, in particular immune-mediated necrotizing myopathy. Read More

    [Myositis: more than a muscle disease].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2312
    Academisch Medisch Centrum-Universiteit van Amsterdam, Amsterdam.
    Idiopathic inflammatory myopathy (IIM), commonly referred to as "myositis", is a rare but treatable auto-immune disease that is often misdiagnosed or diagnosed after significant delay. Using three clinical case reports as introductory examples, an overview is given - and pitfalls are discussed - of the diagnosis and treatment of myositis. Disease features are often extra-muscular in nature, may vary considerably between patients, and are frequently non-specific. Read More

    Focal myositis: New insights on diagnosis and pathology.
    Neurology 2018 Mar 21;90(12):e1013-e1020. Epub 2018 Feb 21.
    From the Department of Internal Medicine (L.G., A.H.), Edouard Herriot University Hospital, Hospices Civils de Lyon; University Claude Bernard (L.G., A.H., F.T.-B., N.S.); INMG (L.G.), CNRS UMR 5310-INSERM U1217; Department of Neurology (P.P.), Croix-Rousse Hospital, Hospices Civils de Lyon; Department of Pathology, Neurology and Neurosurgery (F.T.-B., N.S.), Pierre Wertheimer University Hospital, Hospices Civils de Lyon; Service de Biostatistique (D.M.-B.), Hospices Civils de Lyon; Université de Lyon (D.M.-B.); Université Lyon 1 (D.M.-B.); and CNRS UMR5558 (D.M.-B.), Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.
    Objective: To better define in a cohort study the clinical and pathologic features of focal myositis (FM).

    Methods: With the use of the usual clinicopathologic definition, each confirmed case of FM in the Lyon University Hospital's myopathologic database between 2000 and 2016 was retrieved. Clinical, pathologic, imaging, serologic, and therapeutic data were collected. Read More

    What is in the Myopathy Literature?
    J Clin Neuromuscul Dis 2018 Mar;19(3):131-134
    Departments of Neurology and Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA.
    This review is focused on recent reports of sporadic inclusion body myositis (sIBM), myopathy in patients with human immunodeficiency virus type 1 (HIV) infection, and necrotizing autoimmune myopathy with antibodies to signal recognition particle. The sIBM articles cover associations with certain genetic polymorphisms, the possible pathogenic role of anti-cytosolic 5'-nucleotidase 1A antibody, and disease-related burden and health care costs. Another article addressed the possible pathogenic role of signal recognition particle antibody in necrotizing myopathy. Read More

    Mitochondrial DNA Deletions With Low-Level Heteroplasmy in Adult-Onset Myopathy.
    J Clin Neuromuscul Dis 2018 Mar;19(3):117-123
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
    We report the cases of 2 patients who presented to our Myositis Center with myalgias and elevated creatine kinase levels. Muscle biopsy showed pathological features consistent with mitochondrial myopathy. In both cases, a single large deletion in mitochondrial DNA at low-level heteroplasmy was identified by next-generation sequencing in muscle tissue. Read More

    Ultrasonographic images of the hand in a case with early eosinophilic fasciitis.
    J Med Ultrason (2001) 2018 Feb 20. Epub 2018 Feb 20.
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
    Eosinophilic fasciitis (EF), a rare rheumatic disease, usually affects the limbs symmetrically and generally spares the hands and feet. Cases of unilateral hand involvement are rarely reported. Here, we report such a rare case. Read More

    Use of High-Flow Nasal Cannula Oxygen Therapy in a Pregnant Woman with Dermatomyositis-Related Interstitial Pneumonia.
    Case Rep Crit Care 2017 31;2017:4527597. Epub 2017 Dec 31.
    Department of Anesthesiology, Kansai Medical University Hospital, Osaka, Japan.
    A 33-year-old pregnant woman was referred to our hospital with respiratory distress at 30 weeks of gestation. Chest computed tomography (CT) scans revealed pulmonary infiltrates along the bronchovascular bundles and ground-glass opacities in both lungs. Despite immediate treatment with steroid pulse therapy for suspected interstitial pneumonia, the patient's condition worsened. Read More

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