21,771 results match your criteria Infectious Myositis


Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study.

Clin Rheumatol 2019 Apr 19. Epub 2019 Apr 19.

Division of Diagnostic Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: To determine the prevalence of clinical manifestations and incidence rate of cardiopulmonary complications in a comparison between men and women with early SSc.

Methods: An inception cohort of early-SSc patients at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, between January 2010 and June 2016, was used. All patients were assessed for clinical manifestations and underwent ECG, echocardiography, and HRCT at the study entry and then annually. Read More

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http://dx.doi.org/10.1007/s10067-019-04551-zDOI Listing

A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy.

Front Immunol 2019 2;10:638. Epub 2019 Apr 2.

Division of Pediatric Rheumatology, Department of Pediatrics, Duke University, Durham, NC, United States.

Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. Practically, this attempt to foretell an occurrence and predict its outcomes is evident in multiple disciplines ranging from meteorology to sociologic studies. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00638
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http://dx.doi.org/10.3389/fimmu.2019.00638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454149PMC
April 2019
1 Read

MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

RMD Open 2019 28;5(1):e000850. Epub 2019 Mar 28.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM.

Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443133PMC
March 2019
1 Read

[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
5 Reads

Myopathy in a 61-year-old Hispanic man.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

A 61-year-old Hispanic man presented to a county hospital for subacute progressive weakness, heliotrope rash and dysphagia. There was initial suspicion for dermatomyositis (DM) given the history; however, the physical exam was not consistent. An MRI followed by a muscle biopsy revealed necrotising autoimmune myositis and anti-3-hydroxy-3-methylglutary-coenzyme A-reductase antibody titers returned positive; the patient was diagnosed with necrotising autoimmune myositis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22889
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http://dx.doi.org/10.1136/bcr-2018-228892DOI Listing
April 2019
2 Reads

Acute flaccid paralysis in North East Delta, Egypt: A retrospective analysis of prospectively collected surveillance data.

J Infect Public Health 2019 Apr 13. Epub 2019 Apr 13.

Ministry of Health, Egypt. Electronic address:

Background: Effective acute flaccid paralysis (AFP) surveillance is crucial in countries approaching the final phase of polio eradication. Thus this study was conducted to highlight the epidemiological pattern of AFP as a surveillance tool for polio in Egypt.

Methods: A record-based descriptive study was conducted to include all AFP cases (599) reported in the last 9 years starting from January 2009 to December 2017 in Dakahlia, North East of Delta, Egypt. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193012
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http://dx.doi.org/10.1016/j.jiph.2019.03.016DOI Listing
April 2019
2 Reads

Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

J Autoimmun 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

Objectives: To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients.

Methods: Adult patients with confirmed IIM recruited to the EuroMyositis registry (n = 1637) from four centres were investigated for the presence of MSAs/MAAs by radiolabelled-immunoprecipitation, with confirmation of anti-MDA5 and anti-NXP2 by ELISA. Clinical associations for each autoantibody were calculated for 1483 patients with a single or no known autoantibody by global linear regression modelling. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.001DOI Listing
April 2019
1 Read

Clinical Utility of RNA Sequencing to Resolve Unusual GNE Myopathy with a Novel Promoter Deletion.

Muscle Nerve 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.

Introduction: UDP N-acetylglucosamine2-epimerase/N-acetylmannosamine-kinase (GNE) gene mutations can cause mostly autosomal-recessive myopathy with juvenile-onset known as hereditary-inclusion-body-myopathy (HIBM).

Methods: We describe a family of a patient showing an unusual HIBM with both vacuolar myopathy and myositis without quadriceps-sparing, hindering diagnosis. We show how genetic testing with functional assays, clinical transcriptome sequencing (RNA-seq) in particular, helped facilitate both the diagnosis and a better understanding of the genotype-phenotype relationship. Read More

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http://dx.doi.org/10.1002/mus.26486DOI Listing
April 2019
1 Read

Voriconazole-induced Myositis in a Double Lung Transplant Recipient.

Cureus 2019 Feb 1;11(2):e3998. Epub 2019 Feb 1.

Internal Medicine, University of Kentucky School of Medicine, Lexington, USA.

Voriconazole is a triazole antifungal agent commercially approved in 2002. It is commonly used in immunocompromised patients as a therapeutic and prophylactic agent. We present the case of a 26-year-old Caucasian female who is a double lung transplant recipient who presented with complaints of generalized left lower extremity swelling and extreme tenderness of her left thigh. Read More

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https://www.cureus.com/articles/17324-voriconazole-induced-m
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http://dx.doi.org/10.7759/cureus.3998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445561PMC
February 2019
2 Reads

ACTA1-myopathy with prominent finger flexor weakness and rimmed vacuoles.

Neuromuscul Disord 2019 Mar 2. Epub 2019 Mar 2.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

Actinopathy is a group of clinically and pathologically heterogeneous myopathies due to mutations in the skeletal muscle sarcomeric α-actin 1-encoding gene (ACTA1). Disease-onset spans from prenatal life to adulthood and weakness can preferentially affect proximal or distal muscles. Myopathological findings include a spectrum of structural abnormalities with nemaline rods being the most common. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608966183127
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http://dx.doi.org/10.1016/j.nmd.2019.02.012DOI Listing
March 2019
3 Reads

Autoimmune myositis and myasthenia gravis resulting from a combination therapy with nivolumab and ipilimumab for metastatic melanoma.

Eur J Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Rheumatology, Yale New Haven Hospital, Connecticut, USA.

Checkpoint inhibitors are a novel option in the management of metastatic melanomas and many other malignancies. They are used to promote the activation of cytotoxic T-lymphocytes by inhibiting deactivation signals, enabling the immune response to the tumor. Numerous Immune-related adverse effects caused by checkpoint inhibitors have been reported in the literature. Read More

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http://dx.doi.org/10.5152/eurjrheum.2019.18159DOI Listing
April 2019
1 Read

Polyphasic Rhabdomyositis in California Sea Lions ( Zalophus Californianus): Pathology and Potential Causes.

Vet Pathol 2019 Apr 14:300985819829526. Epub 2019 Apr 14.

3 The Marine Mammal Center, Sausalito, CA, USA.

A myositis syndrome has been recognized for more than a decade in California sea lions (CSLs; Zalophus californianus) but a detailed description of the lesions and potential causes of this condition is lacking. The tissues of 136 stranded CSLs with rhabdomyositis were examined. Rhabdomyositis was considered incidental in 67% (91/136) of the CSLs, and a factor contributing to the animal stranding (significant rhabdomyositis) in 33% (45/136). Read More

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http://journals.sagepub.com/doi/10.1177/0300985819829526
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http://dx.doi.org/10.1177/0300985819829526DOI Listing
April 2019
3 Reads

[Treatment of distal humerus fracture with unexposed ulnar nerve medial elbow incision and anatomical locking compression plate].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):440-444

Department of Orthopaedics, Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou Sichuan, 646000,

Objective: To investigate the feasibility and effectiveness of unexposed ulnar nerve medial elbow incision, open reduction and internal fixation of anatomical locking compression plate (LCP) for distal humerus fractures.

Methods: Fourteen patients with distal humerus fracture were treated between January 2014 and June 2017. There were 5 males and 9 females, aged 18-85 years (mean, 65. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201808077
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http://dx.doi.org/10.7507/1002-1892.201808077DOI Listing
April 2019
4 Reads

Difficult case: rituximab in anti-SRP antibody myositis in pregnancy.

Pract Neurol 2019 Apr 12. Epub 2019 Apr 12.

Imperial College Healthcare NHS Trust, London, UK

A 30-year-old nulliparous woman presented at 15-week gestation with severe skeletal and respiratory muscle weakness, having been diagnosed with anti-signal recognition particle antibody myositis 3 years before. Remission had previously been induced with rituximab (after failure of standard therapies). She had continued oral prednisolone and rituximab every 6 months but had stopped this when planning pregnancy. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002168DOI Listing
April 2019
1 Read

Take Two: Utility of The Repeat Skeletal Muscle Biopsy.

Muscle Nerve 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurology, University of Colorado School of Medicine, Denver, CO.

Introduction: The utility of repeat muscle biopsy has not been adequately evaluated.

Methods: A retrospective review was undertaken of 144 repeat muscle biopsies performed from 1980-2017. Repeat biopsy was considered clinically relevant if it provided a new diagnosis, changed the existing diagnosis, or led to treatment changes or further investigations. Read More

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http://dx.doi.org/10.1002/mus.26484DOI Listing
April 2019
1 Read

Atypical Presentation of Human Acute Muscular Sarcocystosis: Sarcocystis Nesbitti Confirmed on Molecular Testing.

Am J Case Rep 2019 Apr 11;20:499-502. Epub 2019 Apr 11.

Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore.

BACKGROUND Acute muscular sarcocystosis (AMS) is one of a spectrum of diseases caused by the Sarcocystis parasite which infects humans in regions where it is endemic. Infections present with non-specific signs and symptoms and have been known to occur in clusters. CASE REPORT A 51-year-old Vietnamese male presented to Tan Tock Seng Hospital, Singapore with 3 weeks of fever, urticarial rash, non-productive cough, and lower back pain. Read More

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http://dx.doi.org/10.12659/AJCR.913327DOI Listing
April 2019
1 Read

Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
1 Read

Human Trichinosis and febrile myositis.

QJM 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Trichinosis is a parasitic infection caused by nematodes of the genus Trichinella. It is acquired by the ingestion of undercooked meat containing cysts of Trichinella species from either a domestic or sylvatic animal. Although considered to be a re-emerging zoonosis, there is lack of awareness among clinicians regarding the presentation of the disease. Read More

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http://dx.doi.org/10.1093/qjmed/hcz081DOI Listing
April 2019
1 Read

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

The ILD-GAP risk prediction model performs poorly in myositis-associated interstitial lung disease.

Respir Med 2019 Apr 21;150:63-65. Epub 2019 Feb 21.

Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 500, Baltimore, MD, 21224, USA. Electronic address:

Purpose: Myositis-associated interstitial lung disease (MA-ILD) is associated with increased mortality, but no prognostic model exists in this population. The ILD-GAP index was developed to predict mortality risk across all subtypes of chronic ILD. The purpose of this study was to validate the ILD-GAP risk prediction model in patients with MA-ILD. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461370PMC
April 2019
1 Read

Absence of sarcoplasmic MxA expression in antisynthetase syndrome in cohort of 194 cases.

Neuropathol Appl Neurobiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

We have read with great interest the recent article entitled 'Diagnostic potential of sarcoplasmic MxA expression in subsets of dermatomyositis' by Uruha et al. [1]. The authors validated the diagnostic utility of myxovirus resistance protein A (MxA) expression in myofibers in dermatomyositis (DM) as compared with other diagnostic markers regardless of subsets, following the first report for MxA as a diagnostic marker of DM [2]. Read More

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http://dx.doi.org/10.1111/nan.12551DOI Listing
April 2019
1 Read
3.927 Impact Factor

A Nonsmoker Man in His 40s With a Diagnosis of Genetic-Related Idiopathic Pulmonary Fibrosis (Surfactant-Protein C Gene Mutation).

Chest 2019 Apr;155(4):e91-e96

Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy. Electronic address:

A nonsmoker man in his 40s underwent bilateral lung transplantation with a referral diagnosis of genetic-related idiopathic pulmonary fibrosis (IPF). The patient had no medical history in childhood and early adulthood, nor was there a family history of IPF. His nonsmoker father presented with lung cancer at 59 years of age. Read More

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http://dx.doi.org/10.1016/j.chest.2018.12.015DOI Listing
April 2019
2 Reads

Screening for Myositis Antibodies in Interstitial Lung Disease.

Lung 2019 Apr 5. Epub 2019 Apr 5.

Cork University Hospital, Wilton, Cork, Ireland.

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http://dx.doi.org/10.1007/s00408-019-00226-3DOI Listing

Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 28 Yongun-dong, Chongno-gu, Seoul 110-744, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address:

Objectives: HLA genes are a major genetic risk factor for myositis and myositis specific antibodies (MSAs), exhibiting unique HLA backgrounds for myositis in different ethnic groups. This is the first large scale Korean study to genotype the HLA-DRB1 and -DPB1 alleles and to examine their association with myositis and MSAs.

Methods: HLA-DRB1 and HLA-DPB1 alleles and MSAs were examined in 179 patients with dermatomyositis (DM, n = 129) or polymyositis (PM, n = 50) and healthy controls (n = 800 for HLA-DRB1, n = 548 for HLA-DPB1). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.005DOI Listing
March 2019
4 Reads

Brain Infection by Hepatitis E Virus Probably via Damage of the Blood-Brain Barrier Due to Alterations of Tight Junction Proteins.

Front Cell Infect Microbiol 2019 19;9:52. Epub 2019 Mar 19.

Laboratory of Animal Pathology and Public Health, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Extrahepatic injury, particularly neurologic dysfunctions such as Guillain-Barré syndrome, neurologic amyotrophy, and encephalitis/meningoencephalitis/myositis were associated with HEV infection, which was supported by both clinical and laboratory studies. Thus, it is crucial to figure out how the virus invades into the central nervous system (CNS). In this study, CNS lesions were determined in rabbits and Mongolian gerbils inoculated with genotype 4 HEV. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436201PMC
March 2019
1 Read

Fibro-osseous Pseudotumor of digits and myositis Ossificans show consistent COL1A1-USP6 rearrangement: a Clinicopathological and genetic study of 27 cases.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Šikl's Department of Pathology, Charles University in Prague, The Faculty of Medicine and Faculty Hospital in Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic; Bioptická laboratoř s.r.o., Mikulášske nám. 4, 326 00, Pilsen.

Myositis ossificans (MO) and fibro-osseous pseudotumor of digits (FOPD) are localized, self-limiting bone-producing pseudosarcomatous lesions characterized by nodular fasciitis-like proliferation and osteoid and immature woven bone production, which may eventually develop into more mature lamelar bone. Traditionally, MO/FOPD were thought to be of reactive, non-neoplastic nature. USP6 gene rearrangement was recently reported as a consistent finding in MO and FOPD, thus expanding the spectrum of transient, USP6-rearranged neoplasms. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.009DOI Listing
April 2019
2 Reads

Cardiometabolic risk and subclinical vascular damage assessment in idiopathic inflammatory myopathies: a challenge for the clinician.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Institute of Clinical Physiology CNR, Pisa, Italy.

Objectives: A high prevalence of cardiovascular disease (CVD), not fully explained by the prevalence of traditional risk factors only, is reported in patients with idiopathic inflammatory myopathies (IIMs). Thus, we investigated if novel markers of CVD risk, like carotid diameter and advanced glycated end products, can better predict increased CVD risk in IIM patients.

Methods: We studied 43 consecutive patients diagnosed with IIM. Read More

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March 2019
3 Reads
2.724 Impact Factor

Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Research and Development, Inova Diagnostics, San Diego, CA, USA.

Objectives: The objective of this study was to compare the results obtained from different assays for the detection of anti-Mi-2 antibodies, which are important markers in the diagnosis of DM.

Methods: The study included 82 patients (68 females/14 males), most of whom had DM (n = 57), followed by PM (n = 16) and juvenile DM (n = 9). All samples were tested using a novel particle-based multi-analyte technology (PMAT) (Inova Diagnostics, research use only) in parallel with a line immunoassay (LIA: Euroimmun). Read More

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http://dx.doi.org/10.1093/rheumatology/kez092DOI Listing
April 2019
1 Read

Clinical significance of myositis-specific autoantibodies.

Authors:
Ran Nakashima

Immunol Med 2018 Sep 17;41(3):103-112. Epub 2018 Nov 17.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

To date, increasing numbers of myositis-specific autoantibodies (MSAs) have been reported and their clinical significance has been elucidated. Anti-aminoacyl-tRNA synthetase (ARS) and anti-melanoma-differentiation associated gene 5 (MDA5) are strongly associated with interstitial lung disease (ILD); however, the clinical course of ILD is different depending on which autoantibody is present. Anti-ARS is associated with chronic and repetitive ILD and anti-MDA5 is associated with rapidly progressive ILD. Read More

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http://dx.doi.org/10.1080/25785826.2018.1531188DOI Listing
September 2018
3 Reads

Myositis an evolving spectrum of disease.

Immunol Med 2018 Jun 11;41(2):46-54. Epub 2018 Sep 11.

b Division of rheumatology, Department of Medicine , Solna, Karolinska Institutet, and Karolinska University Hospital , Stockholm , Sweden.

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of disorders characterized, as common feature, by inflammation of skeletal muscle and muscle weakness. Traditionally, IIMs have been subclassified in into polymyositis, dermatomyositis and inclusion body myositis, but this subclassification has several limitations, because clinical features as well as treatment response vary within the three IIM subgroups. In the last years several novel autoantibodies in patients with IIMs have been identified. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481571DOI Listing
June 2018
6 Reads

Benign Acute Childhood Myositis: A Benign Disease that Mimics More Severe Neuromuscular Disorder.

J Pediatr Neurosci 2018 Oct-Dec;13(4):404-409

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Context: Proximal lower limb weakness presenting acutely with or without preceding fever is a strong mimic of Guillain-Barré syndrome (GBS). Benign acute childhood myositis (BACM) forms an important differential diagnosis in such cases.

Aim: To characterize the clinical and laboratory findings of patients with BACM for better understanding of the disease. Read More

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http://dx.doi.org/10.4103/JPN.JPN_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413614PMC
April 2019
8 Reads

Low-level Parasite Persistence Drives Vasculitis and Myositis in Skeletal Muscle of Mice Chronically-infected with.

Infect Immun 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

In chronic () infection, the cause of Chagas disease, life-threatening inflammatory diseases develop over time in the heart, esophagus, and colon of some patients. C57BL/6 mice infected with the myotropic strain of model many of the immunologic and parasitologic features of the human infection but succumb to chronic paralyzing myositis and skeletal muscle vasculitis, not cardiomyopathy or gastrointestinal disease. Here we show that T cell depletion in the chronic phase of this model increased tissue parasitism to acute phase levels, and induced neutrophilic skeletal muscle inflammation. Read More

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http://dx.doi.org/10.1128/IAI.00081-19DOI Listing

Myalgia, Obtundity and Fever in a Patient with a Prosthesis.

Eur J Case Rep Intern Med 2019 8;6(2):001021. Epub 2019 Feb 8.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Objective: We describe a rare case of group G streptococcus (GGS) sepsis complicated by bacterial toxin myopathy.

Case: A 65-year-old man, with a history of infection of his shoulder prosthesis, presented with multiorgan failure and notable myalgia likely caused by toxins. The patient was treated successfully with antibiotics and prosthesis removal. Read More

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http://dx.doi.org/10.12890/2019_001021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432832PMC
February 2019
1 Read

Snakebite (Protobothrops mucrosquamatus)-related myositis.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.03.013DOI Listing
March 2019
2 Reads

Cytometric cell-based assays for anti-striational antibodies in myasthenia gravis with myositis and/or myocarditis.

Sci Rep 2019 Mar 27;9(1):5284. Epub 2019 Mar 27.

Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

The purposes of the present study were to identify anti-striational antibodies in myasthenia gravis (MG) patients with myositis and/or myocarditis using a combination of cell-based assays and flow cytometry (cytometric cell-based assays) and to describe the main clinical implications. Among 2,609 stored samples collected from all over Japan between 2003 and 2016, we had serum samples from 30 MG patients with myositis and/or myocarditis. Cytometric cell-based assays with titin, ryanodine receptor, and voltage-gated Kv1. Read More

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http://dx.doi.org/10.1038/s41598-019-41730-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437199PMC
March 2019
2 Reads

Specific Autoantibodies and Clinical Phenotypes Correlate with the Aberrant Expression of Immune-Related MicroRNAs in Dermatomyositis.

J Immunol Res 2019 19;2019:2927061. Epub 2019 Feb 19.

Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, Beijing 100029, China.

Aims: The serum concentrations of miRNAs, miR-23a-3p, miR-23b-3p, miR-146a-5p, miR-146b-5p, and miR-150-5p, were shown to be associated with the immune and inflammatory progressions. We assessed the expressions of these five miRNAs in association with clinical phenotypes and myositis-specific autoantibody-defined subgroups of dermatomyositis (DM).

Methods: The present study included 49 patients with DM and 30 healthy controls. Read More

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http://dx.doi.org/10.1155/2019/2927061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399529PMC
February 2019
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Diagnostic Utility of Separate Anti-Ro60 and Anti-Ro52/TRIM21 Antibody Detection in Autoimmune Diseases.

Front Immunol 2019 12;10:444. Epub 2019 Mar 12.

Laboratory of Dermatology, Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France.

Anti-SS-A antibodies are often sought for in autoimmune diseases diagnosis. Two different target proteins have actually been identified: Ro52 and Ro60. Clinical and immunological associations seem different depending on anti-Ro52 or anti-Ro60 antibodies presence. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423153PMC
March 2019
1 Read

Letter in response to 'Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors'.

Eur J Cancer 2019 Mar 23;112:47-48. Epub 2019 Mar 23.

Department of Medicine, McGill University, Canada; Division of Rheumatology, Jewish General Hospital, Montreal, Canada; Lady Davis Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ejca.2019.02.010DOI Listing
March 2019
5 Reads

Myositis associated with A bacteremia appears to be common.

J Family Med Prim Care 2019 Jan;8(1):125-129

Department of Neurology, JIPMER, Puducherry, India.

Background: Fever and severe myalgia in a tropical country like India bring to mind leptospirosis, rickettsioses, dengue, and other viral fevers. Enteric fever is widely prevalent in Asia, but myositis has not been previously described in A bacteremia.

Materials And Methods: Retrospectively, we recruited patients with enteric fever admitted to our treating unit over a 6-month period. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_202_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396611PMC
January 2019
3 Reads

An Interesting Presentation of Lyme Pseudothrombophlebitis.

Pediatr Emerg Care 2019 Mar 21. Epub 2019 Mar 21.

From the Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Philadelphia, PA.

An 8-year-old boy presented to the emergency department with swelling and pain of his left knee and calf for approximately 1 week. His examination was significant for moderate knee effusion and swelling of the posterior calf with erythema and warmth of the affected areas. An ultrasound obtained at an outside hospital showed a large heterogeneous mass in the gastrocnemius, and a magnetic resonance imaging revealed a large, heterogeneous, rim-enhancing collection in the medial head of the left gastrocnemius muscle with surrounding myositis involving the gastrocnemius muscle. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001826DOI Listing

Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies.

Clin Rheumatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Clinical Immunology and Rheumatology, St John's Medical College, Sarjapur Road, Bengaluru, 560034, India.

Bohan and Peter is the oldest criteria for the classification of idiopathic inflammatory myopathies (IIM). Recently, 2017 EULAR/ACR criteria were introduced which were validated against a control group. The objective of this study was to assess the performance of the 2017 EULAR/ACR criteria in retrospective cohort of adult and juvenile idiopathic inflammatory myopathies and compare with Bohan and Peter criteria. Read More

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http://dx.doi.org/10.1007/s10067-019-04512-6DOI Listing
March 2019
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Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: a nationwide population study in Taiwan.

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context.

Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ⩾18 years who were eligible for the Taiwan catastrophic illness certificate. Read More

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http://dx.doi.org/10.1093/rheumatology/kez076DOI Listing
March 2019
5 Reads

Neutrophilic eccrine hidradenitis secondary to pegfilgrastim in a patient with synovial sarcoma.

Clin Case Rep 2019 Mar 7;7(3):533-536. Epub 2019 Feb 7.

University of Kansas Hospital Kansas City Kansas.

Here, we report a case of neutrophilic eccrine hidradenitis (NEH) in a teenage male with synovial sarcoma associated with extracutaneous manifestations including myositis and splenomegaly secondary to pegfilgrastim. To the best of our knowledge, NEH has not been previously reported to occur in association with extracutaneous manifestations. Read More

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http://dx.doi.org/10.1002/ccr3.1932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406152PMC
March 2019
2 Reads

A rare presentation of benign acute childhood myositis.

Clin Case Rep 2019 Mar 29;7(3):461-464. Epub 2019 Jan 29.

The Department of Orthopaedics and Traumatology University of Hong Kong Hong Kong China.

Benign acute childhood myositis is a self-limiting muscle disorder characterized by calf pain with an isolated finding of elevated serum creatine kinase, being preceded by an influenza-like illness. The classic clinical and laboratory features may allow for a correct diagnosis. This report describes some accompanying symptoms which are not usually perceived. Read More

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http://doi.wiley.com/10.1002/ccr3.2001
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http://dx.doi.org/10.1002/ccr3.2001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406135PMC
March 2019
9 Reads

Neurotoxicity associated with cancer immunotherapy: immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy.

Curr Opin Neurol 2019 Mar 19. Epub 2019 Mar 19.

Department of Oncology.

Purpose Of Review: Immune checkpoint inhibitors (ICPI) and chimeric antigen receptor T cells (CAR-T) represent novel therapies recently approved to treat a number of human cancers. As both approaches modulate the immune system, they can generate a number of immune-related adverse events (irAEs), including a large spectrum of novel neurological toxicities. These are of special interest given their potential severity and risk of compromising further oncologic treatment. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000686DOI Listing
March 2019
2 Reads

A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis.

J Gen Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Stanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.

We discuss a challenging case of a 58-year-old Vietnamese-American woman who presented to her new primary care provider with an 8-year history of slowly progressive dysphagia, hoarseness, muscle weakness with associated frequent falls, and weight loss. She eventually reported dry eyes and dry mouth, and she was diagnosed with Sjogren's syndrome. Subsequently, she was additionally diagnosed with inclusion body myositis and gastric light-chain (AL) amyloidosis. Read More

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http://dx.doi.org/10.1007/s11606-019-04931-wDOI Listing
March 2019
3 Reads

A Case of Progressive Ossifying Fibrodysplasia of Tracheobronchial Respiratory Muscles.

Case Rep Radiol 2019 11;2019:5095343. Epub 2019 Feb 11.

Radiology Department of Bingerville University Hospital, Abidjan, Côte d'Ivoire.

The authors report a case of progressive ossifying myositis (POM) in a 13-year-old boy, revealed by dry cough and dyspnea. Conventional chest x-rays and whole-body CT showed extraskeletal ossification that seems to affect the left bronchial strain and trachea. This lesional topography, if established, not yet described to our knowledge, contrasts with the observations of all the authors, including Munchmeyer, for whom smooth muscles and muscles attached to the skeleton by a single end are spared by the heterotopic ossifications characteristic of the disease. Read More

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http://dx.doi.org/10.1155/2019/5095343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388317PMC
February 2019
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Distinct interferon signatures stratify inflammatory and dysimmune myopathies.

RMD Open 2019 26;5(1):e000811. Epub 2019 Feb 26.

IMRB, Inserm U955-Team 10, Paris Est-Creteil University, Paris, France.

Objective: The role of interferons (IFN) in the pathophysiology of primary inflammatory and dysimmune myopathies (IDM) is increasingly investigated, notably because specific neutralisation approaches may constitute promising therapeutic tracks. In present work we analysed the muscular expression of specific IFNα/β and IFNγ-stimulated genes in patients with various types of IDM.

Methods: 39 patients with IDM with inclusion body myositis (IBM, n=9), dermatomyositis (DM, n=10), necrotising autoimmune myopathies (NAM, n=10) and antisynthetase myositis (ASM, n=10), and 10 controls were included. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00081
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http://dx.doi.org/10.1136/rmdopen-2018-000811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397431PMC
February 2019
6 Reads

Polypropylene Mesh Repair of Traumatic Hernia of the Vastus Lateralis: Case Report and Review.

Plast Reconstr Surg Glob Open 2019 Feb 25;7(2):e2101. Epub 2019 Feb 25.

CIC (Centre d'Image Corporelle), Nyon, Switzerland.

Myofascial herniations of the lower limb are a rare cause of chronic nerve compression and pain. They may have congenital or traumatic origin, and the tibialis anterior muscle is the most frequent localization. A few cases will require operative management. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416141PMC
February 2019
1 Read