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    21025 results match your criteria Infectious Myositis

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    Imaging of Kingella kingae musculoskeletal infections in children: a series of 5 cases.
    Emerg Radiol 2018 Jun 16. Epub 2018 Jun 16.
    Department of Radiology, CSC, MC 3252, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792-3252, USA.
    Purpose: Kingella kingae musculoskeletal infections continue to be under-diagnosed and there remains a paucity of literature on its imaging features. The purpose of this manuscript is to review the imaging, clinical, and laboratory findings of microbiology-proven K. kingae infections. Read More

    Immune checkpoint-mediated myositis and myasthenia gravis: A case report and review of evaluation and management.
    Am J Otolaryngol 2018 Jun 5. Epub 2018 Jun 5.
    Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
    Background: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).

    Methods: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease. Read More

    The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease.
    Arch Rheumatol 2018 Mar 12;33(1):26-32. Epub 2017 Oct 12.
    Department of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, Tokyo, Japan.
    Objectives: This study aims to analyze the distribution and clinicopathological characteristics of anti-aminoacyl-transfer ribonucleic acid (tRNA) synthetase (ARS) antibodies in rheumatoid arthritis patients.

    Patients And Methods: We retrospectively studied the anti-ARS antibody levels in 228 RA patients' (44 males, 184 females; mean age 62.9±14. Read More

    Ankylosing Neurogenic Myositis Ossificans of the Hip: A Case Series and Review of Literature.
    Hip Pelvis 2018 Jun 4;30(2):86-91. Epub 2018 Jun 4.
    Department of Orthopaedic Surgery, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
    Purpose: Neurogenic myositis ossificans (NMO) in patients with traumatic spinal cord or brain injuries can cause severe joint ankylosis or compromise neurovascularture. The purpose of this study was to evaluate the clinical and radiological outcomes of and review considerations relevant to surgical resection of NMO of the hip joint.

    Materials And Methods: Six patients (9 hips) underwent periarticular NMO resection between 2015 and 2017. Read More

    A case of severe Pembrolizumab-induced neutropenia.
    Anticancer Drugs 2018 Jun 8. Epub 2018 Jun 8.
    Department of Internal Medicine, Division of Pulmonary Diseases, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    Immune checkpoint inhibitors have revolutionized cancer therapy. Given their mechanism of action, immune-related adverse events have been associated with their use. We present the first documented case of pembrolizumab-induced grade IV neutropenia. Read More

    Immune checkpoint failures in inflammatory myopathies: An overview.
    Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.
    Department of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium.
    Dermatomyositis (DM), polymyositis (PM), inclusion bosy myositis (IBM), immune mediated necrotizing myopathy (IMNM) and overlap myositis (OM) are classified as inflammatory myopathies (IM) with involvement of autoimmune features such as autoreactive lymphocytes and autoantibodies. Autoimmunity can be defined as a loss in self-tolerance and attack of autoantigens by the immune system. Self-tolerance is achieved by a group of immune mechanisms occurring in central and periphal lymphoid organs and tissues, called immune checkpoints, that work in synergy to protect the body from harmful immune reactions. Read More

    Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis.
    Arthritis Res Ther 2018 Jun 8;20(1):117. Epub 2018 Jun 8.
    Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, 2.706 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
    Background: The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultraviolet (UV) light towards the equator. In this study, we investigated whether differing genetic background in populations could contribute to this distribution of DM. Read More

    [Serum free light chains for monitoring systemic lupus erythematosus activity].
    Wiad Lek 2018 ;71(1 pt 1):21-31
    Klinika Reumatologii i Układowych Chorób Tkanki Łącznej Uniwersytetu Medycznego w Lublinie, Lublin, Polska.
    Objective: Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease leading to chronic inflammation of numerous tissues and organs. The search for clinically useful markers of its activity is ongoing. At present, it is suggested that serum free light chains (FLC) may be useful in assessing SLE activity. Read More

    Experimental Transmission of Frog Virus 3-Like Ranavirus in Juvenile Chelonians at Two Temperatures.
    J Wildl Dis 2018 Jun 7. Epub 2018 Jun 7.
    2   Zoological Pathology Program, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, 3300 Golf Rd., Brookfield, Illinois 60513, USA.
    The pathogenicity of frog virus 3 (FV3)-like ranavirus varies in adult chelonian species at different environmental temperatures, but differences in pathogenicity at different temperatures has yet to be determined in juveniles. Our objective was to determine the susceptibility to FV3-like ranavirus in four species of juvenile chelonians: red-eared sliders (RES; Trachemys scripta elegans), Mississippi map turtles ( Graptemys pseudogeographica kohnii), false map turtles (FMT; Graptemys pseudogeographica), and eastern river cooters ( Pseudemys concinna concinna) at two environmental temperatures. Two simultaneous trials ( n=8 treatment and n=4 controls of each species) were conducted in separate temperature-controlled rooms with animals maintained at 22 C or 27 C. Read More

    Health care costs and comorbidities for patients with inclusion body myositis.
    Curr Med Res Opin 2018 Jun 7:1-16. Epub 2018 Jun 7.
    c Novartis Pharmaceuticals Corporation , New York , NY.
    Objective: This study identifies the health care costs and utilization, as well as comorbidities, in a Medicare population of inclusion body myositis (IBM) patients.

    Methods: Medicare patients aged ≥65 years with a diagnosis claim for IBM were identified and matched to a cohort of non-IBM patients based on age, sex, race, calendar year, and census region. Generalized linear models were used to estimate health care costs and utilization during the follow-up period. Read More

    Mortality, length of stay and cost of hospitalization among patients with systemic sclerosis: results from the National Inpatient Sample.
    Rheumatology (Oxford) 2018 Jun 2. Epub 2018 Jun 2.
    Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.
    Objectives: To evaluate the hospitalizations and define the factors associated with in-hospital mortality, longer length of stay (LOS) and higher hospital costs among SSc hospitalizations.

    Methods: We used the National Inpatient Sample (2012-13) to identify adult hospitalizations with SSc, excluding patients with concomitant diagnosis of RA and systemic lupus. We calculated rates of hospitalization, in-hospital mortality, LOS and hospital costs. Read More

    Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom.
    Case Rep Dermatol 2018 May-Aug;10(2):110-114. Epub 2018 May 4.
    Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
    Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. Read More

    Acute Kidney Injury Secondary to Rhabdomyolysis: A Rare Presentation of Chikungunya Fever.
    J Coll Physicians Surg Pak 2018 Jun;28(6):S94-S96
    Department of Nephrology, The Kidney Centre Postgraduate Training Institute, Karachi.
    Chikungunya fever is an arthropod-borne viral illness characterised by high grade fever and incapacitating arthralgias. It is considered benign; however, in the recent outbreaks, several complications have been reported worldwide. We report a case of male patient with Chikungunya fever, possibly contracted from infected mosquitoes endemic in Karachi, Pakistan. Read More

    Current Classification and Management of Inflammatory Myopathies.
    J Neuromuscul Dis 2018 ;5(2):109-129
    Department of Neurology, Muscle Immunobiology Group, Neuromuscular Center, University MedicalCenter Göttingen, Göttingen, Germany.
    Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) including anti-synthetase syndrome (ASS), and inclusion body myositis (IBM). Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progressive, chronic disease course in IBM, patients with myositis typically present with a subacute onset of weakness of arms and legs, often associated with pain and clearly elevated creatine kinase in the serum. Read More

    Lung Involvements in Rheumatic Diseases: Update on the Epidemiology, Pathogenesis, Clinical Features, and Treatment.
    Biomed Res Int 2018 8;2018:6930297. Epub 2018 May 8.
    Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
    Lung illness encountered in patients with rheumatic diseases bears clinical significance in terms of increased morbidity and mortality as well as potential challenges placed on patient care. Although our understanding of natural history of this important illness is still limited, epidemiologic knowledge has been accumulated during the past decade to provide useful information on the risk factors and prognosis of lung involvements in rheumatic diseases. Moreover, the pathogenesis particularly in the context of genetics has been greatly updated for both the underlying rheumatic disease and associated lung involvement. Read More

    Outcome of Benign Acute Childhood Myositis: The Experience of 2 Large Tertiary Care Pediatric Hospitals.
    Pediatr Emerg Care 2018 Jun;34(6):400-402
    Division of Pediatric Emergency Medicine, Clinical Pharmacology Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Objective: The aims of the study were to determine the evolution of benign acute childhood myositis in children and to assess the relationship between creatine phosphokinase (CPK) values and myoglobinuria.

    Study Design: A retrospective study of patients with benign acute childhood myositis seen in 2 tertiary care university-affiliated pediatric hospitals during overlapping 4-year periods.

    Methods: Demographic data, historical details, clinical, and laboratory results were extracted from the charts of children younger than 16 years with a CPK greater than 3 times normal. Read More

    Combined usage of extracorporeal membrane oxygenation and double filtration plasmapheresis in amyopathic dermatomyositis patient with severe interstitial lung disease: A case report.
    Medicine (Baltimore) 2018 Jun;97(22):e10946
    Department of ICU, Shunde Hospital, Southern Medical University, Foshan Guangdong, China.
    Rationale: We report a man with amyopathic dermatomyositis (ADM) complicated by severe interstitial lung disease (ILD) received extracorporeal membrane oxygenation (ECMO) in combination with double filtration plasmapheresis (DFPP). This is the first report of the utility of ECMO in combination with DFPP in ADM related ILD in adults.

    Patient Concerns: A 48-year-old man who was previously healthy had a 2-month history of cough and shortness of breath, which aggravated in 5 days. Read More

    Clinical features of different orbital manifestations of granulomatosis with polyangiitis.
    Graefes Arch Clin Exp Ophthalmol 2018 May 30. Epub 2018 May 30.
    Institute of Eye Diseases, Rossolimo 11A,B, Moscow, Russia.
    Purpose: The aim of this study was to distinguish different forms of orbital involvement in granulomatosis with polyangiitis (GPA) and to compare their clinical course and outcomes.

    Methods: Two hundred twenty-six consecutive patients with GPA were retrospectively studied. All patients fulfilled the classification criteria of American College of Rheumatology; diagnosis of localized GPA was established according to Chapel Hill Consensus. Read More

    Antibodies to small ubiquitin-like modifier activating enzyme are associated with a diagnosis of dermatomyositis: results from an unselected cohort.
    Immunol Res 2018 May 29. Epub 2018 May 29.
    Department of Pathology, University of Utah, 30N 1900E, Salt Lake City, UT, 84132, USA.
    The aim of this study was to examine the frequency and significance of antibodies targeting the small ubiquitin-like modifier 1 activating enzyme (SAE) in patients under serologic evaluation for idiopathic inflammatory myopathies. Patient sera (n = 17) recognizing bands at approximately 40 (SAE1) and 90 (SAE2) kDa were identified in 6445 consecutive samples for myositis autoantibody evaluation by immunoprecipitation (IP) of S-labeled K562 cell lysate. All 17 positive samples, 176 disease, and 67 healthy controls were evaluated for SAE1 antibodies using a line immunoblot assay (LIA). Read More

    Does muscle biopsy change the treatment of pediatric muscular disease?
    Pediatr Surg Int 2018 Jul 29;34(7):797-801. Epub 2018 May 29.
    Department of Surgery, The Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.
    Background: Muscle biopsy is performed to confirm the diagnosis of neuromuscular disease and guide therapy. The purpose of our study was to determine if muscle biopsy changed patient diagnosis or treatment, which patients were most likely to benefit from muscle biopsy, and complications resulting from muscle biopsy.

    Materials And Methods: An IRB-approved retrospective chart review of all patients less than 18 years old undergoing muscle biopsy between January 2010 and August 2016 was performed. Read More

    Symptomatic muscular sarcoidosis: Lessons from a nationwide multicenter study.
    Neurol Neuroimmunol Neuroinflamm 2018 May 16;5(3):e452. Epub 2018 Mar 16.
    AP-HP (F.C.A., S.A, J.H., A.M., M.P., Z.A), Service de Médecine Interne 2, Institut e3m, Hôpital de la Pitié-Salpêtrière, Centre National de Référence Maladies Systémiques Rares, Lupus, Syndrome des anticorps antiphospholipides; Université Paris VI (F.C.A., J.H., O.B.), UPMC, Sorbonnes Universités; AP-HP (T.M.), Département de neurophysiologie et de neuropathologie, Hôpital de la Pitié-Salpêtrière, Paris; Service de Pneumologie (V.C.), Centre des maladies pulmonaires rares, Lyon; AP-HP (T.P.), Service de Médecine Interne, Hôpital Bichat; AP-HP (L.G., B.H., O.B., Z.A.), Service de Médecine Interne et immunologie clinique, Hôpital de la Pitié-Salpêtrière, Paris; AP-HP (M.S.), Service de Médecine Nucléaire, Hôpital Avicenne, Bobigny; Service de Médecine Interne (P.M.), CHU Bordeaux, Bordeaux; AP-HP (H.N., D.V.), Service de Pneumologie, Hôpital Avicenne, Bobigny, France.
    Objectives: To describe clinicopathologic features of muscular sarcoidosis and the associated sarcoidosis phenotype through a nationwide multicenter study.

    Methods: Patients were included if they had histologically proven sarcoidosis and symptomatic muscular involvement confirmed by biological, imaging, or histologic examinations.

    Results: Forty-eight patients (20 males) were studied, with a median age at muscular symptoms onset of 45 years (range 18-71). Read More

    Pseudomalignant myositis ossificans in the breast: A case report.
    Mol Clin Oncol 2018 Jun 13;8(6):749-752. Epub 2018 Apr 13.
    Alpha Medical Pathology, Ltd., 84101 Bratislava, Slovakia.
    Myositis ossificans (MO) is characterized by abnormal heterotopic ossification formation, typically involving muscles, tendons, ligaments, fascia, and aponeurosis. It can be categorized into nonhereditary and hereditary types, with the latter being a distinct entity with a separate pathophysiology and treatment approach. The pathophysiology of MO formation remains to be fully elucidated. Read More

    Benign acute myositis in an adult patient.
    BMJ Case Rep 2018 May 29;2018. Epub 2018 May 29.
    Neurologie, Hopitaux universitaires de Strasbourg, Strasbourg, France.
    The benign acute childhood myositis presents as a marked and painful oedema of leg muscles in the days following a viral illness. This disease is often considered as occurring only in children. We report the case of a 32-year-old patient who presented with severe pain and oedema of both legs associated with motor deficit of lower extremities. Read More

    Jugular foramen tumour resulting in hypoglossal denervation pseudohypertrophy: a rare and significant cause for tongue asymmetry.
    Int J Oral Maxillofac Surg 2018 May 26. Epub 2018 May 26.
    Oral and Maxillofacial Unit, Monash Health, Victoria, Australia.
    Paragangliomas of the jugular foramen are rare. They may present with symptoms of compression of the glossopharyngeal or vagus nerves, or due to secretion of catecholamines from chromaffin cells within the tumour. This case describes a rare presentation of glomus tumour. Read More

    Respiratory muscle involvement in sarcoidosis.
    Expert Rev Respir Med 2018 May 31:1-4. Epub 2018 May 31.
    a Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Faculty of Health/School of Medicine , Witten/Herdecke University , Cologne , Germany.
    Introduction: In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatigue and reduced health-related quality of life. Read More

    Skeletal Muscle Lymphoma Presenting with Chronic Compartment Syndrome of Leg after Trauma.
    Case Rep Oncol Med 2018 1;2018:4078672. Epub 2018 Apr 1.
    Kaohsiung Medical University Hospital, No. 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
    Compartment syndrome may be acute or chronic based on the clinical course and etiology. Here, we report the first known case to be diagnosed with skeletal muscle-derived B-cell lymphoma presenting with chronic compartment syndrome after trauma. A 62-year-old woman sought medical attention due to a one-month history of painful left lower leg swelling and paresthesia of the medial side of the foot after falling over. Read More

    [Effect of functional exercise at different time and different immobilization positions on functional recovery of elbow joint with type C distal humeral fractures].
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Aug;31(8):946-951
    Department of Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu Sichuan, 610072, P.R.China.
    Objective: To investigate the effect of functional exercises at different time and different immobilization positions on the functional recovery of elbow joint with type C distal humeral fractures.

    Methods: A total of 120 patients with type C distal humeral fractures admitted to the hospital between June 2013 and July 2015 were included in the study. They were randomly allocated to 3 groups, 40 patients in each group. Read More

    [F]Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosing polymyositis/dermatomyositis.
    Exp Ther Med 2018 Jun 13;15(6):5023-5028. Epub 2018 Apr 13.
    Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
    [F]fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG-PET/CT) is useful for diagnosing cancers and inflammatory diseases. A polymyositis/dermatomyositis (PM/DM) lesion is an inflammatory heterogeneous disease of the striated muscle. In the present study, the maximum standardized uptake value (SUV) was compared between 22 cases with definite or probable PM/DM (PM/DM group) that underwent [F]FDG-PET/CT examination and the same number of patients with no myopathy. Read More

    Electrical impedance imaging of human muscle at the microscopic scale using a multi-electrode needle device: A simulation study.
    Clin Neurophysiol 2018 May 15. Epub 2018 May 15.
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215-5491, USA. Electronic address:
    Objective: To use a standard modeling approach to evaluate the feasibility of imaging healthy and diseased skeletal muscle at the microscopic scale with a novel electrical impedance imaging (EII) needle.

    Methods: We modeled an EII needle containing 16 impedance electrodes arranged circumferentially around the shaft of a non-conductive 19-gauge needle in 4 planes. We then combined the finite element method approach with a reconstruction algorithm to create imaging simulations of the electrical properties of the triceps brachii by localized intramuscular fat (as might be seen in any chronic neuromuscular disease) and by localized edema (as in inflammatory myositis or after direct muscle injury). Read More

    [Efficacy of sequential therapy with telbivudine in treatment of HBeAg-positive chronic hepatitis B patients with partial response to pegylated interferon-α therapy].
    Zhonghua Gan Zang Bing Za Zhi 2018 Feb;26(2):102-107
    Department of Liver Research Center, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
    To investigate the efficacy of sequential therapy with telbivudine in the treatment of HBeAg-positive chronic hepatitis B (CHB) patients with partial response after a standard course of interferon therapy. A retrospective cohort study was performed for 58 HBeAg-positive CHB patients with partial response at the end of interferon therapy (48-60 weeks) from January 2009 to December 2013. According to whether telbivudine was used sequentially or withdrawn at the end of the course of treatment, the patients were divided into telbivudine sequential therapy group and withdrawal group, and the two groups were compared with in terms of biochemical, virological, and serological response rates. Read More

    Limb-girdle muscular dystrophy type 2B misdiagnosed as polymyositis at the early stage: Case report and literature review.
    Medicine (Baltimore) 2018 May;97(21):e10539
    Department of Neurology (III), China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
    Rationale: Dysferlin myopathy is an autosomal recessive hereditary muscular dystrophy due to deficiency of dysferlin caused by alteration of the DYSF gene; Limb-girdle muscular dystrophy type 2B (LGMD2B) is the most common in Its clinical phenotypes. However, LGMD2B is rarely seen in clinical cases and may initially present as weakness of proximalpelvis muscles and muscles in the posterior compartments of thighs,which will then cause difficulty in running and limping during walking. Laboratory tests at an early stage of the disease often indicate an increased level of serum creatine kinase (CK). Read More

    Case of Anti-Single Recognition Particle-Mediated Necrotizing Myopathy After Influenza Vaccination.
    J Clin Neuromuscul Dis 2018 Jun;19(4):211-216
    Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
    Immune-mediated necrotizing myopathy is a very rare inflammatory disease affecting skeletal muscles. Immune-mediated necrotizing myopathy may be associated with myositis-specific autoantibodies including anti-single recognition particle and anti-3-hydroxy-3- methylglutaryl-coenzyme A reductase, infectious agents (HIV or hepatitis C), other connective tissue disorders (such as scleroderma), and malignancy. We reported a 28-year-old healthy woman presented with subacute onset ascending muscle weakness 2 weeks after an annual influenza vaccination. Read More

    Myositis and Fasciitis: Role of Imaging.
    Semin Musculoskelet Radiol 2018 Jul 23;22(3):286-298. Epub 2018 May 23.
    Department of Radiology and Imaging, Hospital for Special Surgery, New York, New York.
    Imaging plays an important role in the evaluation of patients presenting with possible myositis, with magnetic resonance imaging the most appropriate modality but ultrasound also playing a complementary role. This article reviews the imaging appearance of the inflammatory myopathies, other forms of myositis, and mimickers of myositis, with a discussion of distinguishing features for each entity. The fascia and disease processes that preferentially involve the fascia are also reviewed. Read More

    Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia.
    Rom J Intern Med 2018 May 21. Epub 2018 May 21.
    Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia.
    Introduction: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia.

    Methods: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015. Read More

    Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement.
    Ann Diagn Pathol 2018 May 12;35:53-55. Epub 2018 May 12.
    Department of Pathology (Pathologie-DNA), Diakonessenhuis Utrecht, Utrecht, The Netherlands.
    Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Read More

    Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis.
    Biomed Res Int 2018 29;2018:5069042. Epub 2018 Jan 29.
    Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
    Sporadic inclusion body myositis (sIBM) is considered the most common acquired myopathy aged over 50 years. The disease is characterized by a particular process of muscle degeneration characterized by abnormal deposit of protein aggregates in association with inflammation. The aim of this study was to present clinical and muscle histopathological findings, including immunostaining for LC3B, p62, -synuclein, and TDP-43, in 18 patients with sIBM. Read More

    Trismus, masticatory myositis and antibodies against type 2M fibers in a mixed breed cat.
    JFMS Open Rep 2018 Jan-Jun;4(1):2055116918764993. Epub 2018 Apr 26.
    Comparative Neuromuscular Laboratory, School of Medicine, University of California San Diego, La Jolla, CA, USA.
    Case Summary: A 1-year-old male neutered mixed breed cat presented with a 2 month history of inability to fully open the mouth when yawning and decreased ability to prehend food. Physical examination revealed severe bilaterally symmetrical masticatory muscle atrophy, a restricted vertical mandibular range of motion of 11-12 mm, and a normal body condition score. Skull radiography was normal. Read More

    Blood-flow restricted resistance training in patients with sporadic inclusion body myositis: a randomized controlled trial.
    Scand J Rheumatol 2018 May 18:1-10. Epub 2018 May 18.
    b Department of Clinical Research , University of Southern Denmark , Odense , Denmark.
    Objectives: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM).

    Method: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week. Read More

    Juvenile dermatomyositis: Latest advances.
    Best Pract Res Clin Rheumatol 2017 Aug 10;31(4):535-557. Epub 2018 Jan 10.
    Paediatric Rheumatology Department, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, United Kingdom. Electronic address:
    Registries and biobanks for juvenile dermatomyositis (JDM) have generated statistical power to help understand pathogenesis and determine treatment and long-term outcomes in this rare and heterogeneous disease. Genotype, autoantibodies, muscle histology and early clinical features may predict prognosis and guide personalised treatment. While corticosteroids and disease-modifying anti-rheumatic drugs improve outcomes, there remain children who experience refractory disease. Read More

    Medications received by patients with juvenile dermatomyositis.
    Semin Arthritis Rheum 2018 Mar 28. Epub 2018 Mar 28.
    Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Building 10, Rm 4-2352, MSC 1301, 10 Center Drive, Bethesda, MD 20892-1301. Electronic address:
    Objective: Few controlled studies are available to guide treatment decisions in juvenile dermatomyositis (JDM). This study evaluated therapies received, changes of treatment over time, and factors associated with medication choices in JDM.

    Methods: We performed a retrospective analysis of the number and type of therapies and duration of treatment for 320 patients with JDM enrolled in a North American registry. Read More

    Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.
    Neuropathol Appl Neurobiol 2018 May 16. Epub 2018 May 16.
    Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
    Aims: To evaluate the relationship between expression of myxovirus-resistance protein A (MxA) protein on muscle biopsies by immunohistochemistry and disease activity in juvenile dermatomyositis (JDM) patients. Also, another aim was to investigate whether the expression of MxA is related with myositis-specific autoantibodies (MSA) status in JDM patients.

    Methods: 103 patients (median aged 6. Read More

    Differential diagnosis of vacuolar muscle biopsies: use of p62, LC3 and LAMP2 immunohistochemistry.
    Acta Myol 2017 Dec 1;36(4):191-198. Epub 2017 Dec 1.
    Center for Neuromuscular Diseases "Paolo Peirolo", Department of Neuroscience "Rita Levi Montalcini", University of Turin, Italy.
    Intrafibral vacuoles are the morphological hallmark in a wide variety of human skeletal muscle disorders with different etiology. In most cases, differential diagnosis is feasible with a routine histochemical work up of muscle biopsy. Ultrastructural analysis is an important confirmatory tool, but it is not widely available. Read More

    Case report: A rare case of focal myositis presenting as Sartorius muscle contracture: A case report and review of literature.
    Medicine (Baltimore) 2018 May;97(20):e10766
    Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China.
    Rationale: Focal myositis (FM) is a very rare myopathy of unknown etiology characterized by focal enlargement within one single skeletal muscle. In particular, it occurs only involving the Sartorius muscle has never been reported.

    Patient Concerns: A 25-year-old man was admitted to the hospital with progressive restricted left hip joint extension, left thigh discomfort and gait disturbance for 6 years. Read More

    Idiopathic inflammatory myopathies in adults: A comparative study of Bohan and Peter and European Neuromuscular Center 2004 criteria.
    Neurol India 2018 May-Jun;66(3):767-771
    Department of Neurology, Institute of Neurological Sciences, Care Hospital, Banjara Hills, Hyderabad, Telangana, India.
    Background: Bohan and Peter criteria are widely used for the diagnosis of idiopathic inflammatory myopathies (IIMs). Recently, European Neuromuscular Center (ENMC) formulated criteria to identify subgroups of IIMs.

    Aim: To compare the two diagnostic criteria in adult IIMs. Read More

    Associations between apparent diffusion coefficient and electromyography parameters in myositis-A preliminary study.
    Brain Behav 2018 May 30;8(5):e00958. Epub 2018 Mar 30.
    Department of Diagnostic and Interventional Radiology University of Leipzig Leipzig Germany.
    Objective: MRI is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Read More

    Klinefelter's syndrome with lupus encephalitis and retroperitoneal teratoma.
    Lupus 2018 Jan 1:961203318776107. Epub 2018 Jan 1.
    3 Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore.
    We report a case of a middle-aged male who presented with pyrexia of unknown origin, oral ulcers, rash and bicytopenia. His past medical history included unexplained proteinuria, infertility and joint pain. Initial workup showed a large retroperitoneal soft tissue mass, which has appeared stable for 10 years. Read More

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