22,881 results match your criteria Infectious Myositis


COVID-19 and the nervous system.

Authors:
Joseph R Berger

J Neurovirol 2020 May 23. Epub 2020 May 23.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

A pandemic due to novel coronavirus arose in mid-December 2019 in Wuhan, China, and in 3 months' time swept the world. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic similarities to the virus (SARS-CoV-1) responsible for the severe acute respiratory syndrome (SARS) epidemic nearly 20 years earlier. The spike proteins of both viruses dictate tissue tropism using the angiotensin-converting enzyme type 2 (ACE-2) receptor to bind to cells. Read More

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http://dx.doi.org/10.1007/s13365-020-00840-5DOI Listing

Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.

Int Immunopharmacol 2020 May 21;85:106611. Epub 2020 May 21.

Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil. Electronic address:

While thioridazine (Tio) inhibits the antioxidant defenses of Trypanosoma cruzi, the gold standard antitrypanosomal drug benznidazole (Bz) has potent anti-inflammatory and pro-oxidant properties. The combination of these drugs has never been tested to determine the effect on T. cruzi infection. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106611DOI Listing

Antibodies against immunogenic epitopes with high sequence identity to SARS-CoV-2 in patients with autoimmune dermatomyositis.

Ann Rheum Dis 2020 May 22. Epub 2020 May 22.

Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Manchester, Manchester, UK

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http://dx.doi.org/10.1136/annrheumdis-2020-217522DOI Listing

Pulmonary and systemic involvement of COVID-19 assessed by ultrasound-guided minimally invasive autopsy.

Histopathology 2020 May 22. Epub 2020 May 22.

BIAS - Brazilian Image Autopsy Study Group, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

Aims: Brazil ranks high in the number of COVID-19 cases and COVID-19's mortality rate. In this context, autopsies are important to confirm the disease, determine associated conditions, and study the pathophysiology of this novel disease. In order to follow biosafety recommendations, we used Ultrasound-Guided Minimally Invasive Autopsy (MIA-US) to assess the systemic involvement of COVID-19 and present the results of ten initial autopsies. Read More

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http://dx.doi.org/10.1111/his.14160DOI Listing

Fatal autoimmune storm after a single cycle of anti-PD-1 therapy: A case of lethal toxicity but pathological complete response in metastatic lung adenocarcinoma.

Hematol Oncol Stem Cell Ther 2020 May 15. Epub 2020 May 15.

Department of Medical Oncology, Hospital Clínico San Carlos, Madrid, Spain.

As immunotherapy agents are incorporated into the routine oncological practice, the number of patients at the risk of immune-related adverse events has increased dramatically. However, the prompt identification and effective management of severe autoimmune complications remain a challenge. We report the case of a patient with metastatic lung adenocarcinoma who experienced a fatal autoimmune storm 3 weeks after the first dose of anti-programmed death receptor-1 (PD-1) agent pembrolizumab, which included thyroiditis, hepatitis, myositis, myocarditis, pneumonitis, and myasthenia gravis. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.04.006DOI Listing

Associations between MRI and EMG findings in myopathies.

Acta Neurol Scand 2020 May 20. Epub 2020 May 20.

Department of Diagnostic and Interventional Radiology, University of Magdeburg, Magdeburg, Germany.

Objectives: Magnetic resonance imaging (MRI) is a cornerstone in diagnosis of myopathies. The present study sought to elucidate possible associations between electromyography (EMG) findings and histogram parameters derived from clinical MRI in myositis and other myopathies.

Materials & Methods: 26 patients with myopathies were included in this retrospective study. Read More

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http://dx.doi.org/10.1111/ane.13284DOI Listing

Knee intra-articular extraskeletal aneurysmal bone cyst: a case report and review of literature.

Skeletal Radiol 2020 May 20. Epub 2020 May 20.

Department of Orthopedic surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Aneurysmal bone cyst (ABC) is a benign locally destructive lesion that usually developed in the bone cavity of bones, less commonly on the surface of cortical bones and very rarely develop outside the bone. There are only 35 reports of extraskeletal aneurysmal bone cyst (ESABC) in the English literature. We report a case of a 12-year-old female with no history of trauma who presented with knee pain. Read More

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http://dx.doi.org/10.1007/s00256-020-03464-2DOI Listing

Statin use in patients with non-HMGCR idiopathic inflammatory myopathies: A retrospective study.

Clin Cardiol 2020 May 20. Epub 2020 May 20.

Division of Rheumatology, University of California Los Angeles, Los Angeles, California, USA.

Background: Statins are the most widely used lipid lowering therapies which reduce cardiovascular risk, but are associated with muscular adverse events (AEs). Idiopathic inflammatory myopathies (IIM) are autoimmune diseases of the muscle with higher risk of cardiovascular disease. More data is needed regarding statin safety in patients with intrinsic muscle disease such as IIM. Read More

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http://dx.doi.org/10.1002/clc.23375DOI Listing

Comparing effectiveness of high-dose Atorvastatin and Rosuvastatin among patients undergone Percutaneous Coronary Interventions: A non-concurrent cohort study in India.

PLoS One 2020 19;15(5):e0233230. Epub 2020 May 19.

Mission Arogya Health and Information Technology Research Foundation, Kolkata, West Bengal, India.

Introduction: Atorvastatin-80mg/day and Rosuvastatin-40mg/day are the commonest high-dose statin (3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors) regimes for post-PCI (Percutaneous Coronary Interventions) patients to lower (by ≥50%) blood low-density-lipoprotein cholesterol (LDL-C). Dearth of conclusive evidence from developing world, regarding overall safety, tolerability and comparative effectiveness (outcome/safety/tolerability/endothelial inflammation control) of Rosuvastatin over Atorvastatin in high-dose, given its higher cost, called for an overall and comparative assessment among post-PCI patients in a tertiary cardiac-care hospital of Kolkata, India.

Methods: A record-based non-concurrent cohort study was conducted involving 942 post-PCI patients, aged 18-75 years, on high-dose statin for three months and followed up for ≥one year. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233230PLOS

Nivolumab resulting in persistently elevated troponin levels despite clinical remission of myocarditis and myositis in a patient with malignant pleural mesothelioma: case report.

Transl Lung Cancer Res 2020 Apr;9(2):360-365

Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Australia.

Malignant pleural mesothelioma (MPM) remains a deadly disease with limited therapeutic options beyond platinum/pemetrexed chemotherapy. Immune checkpoint inhibitors have demonstrated modest benefit in the second to later-line settings. An MPM patient from our institute developed myocarditis and myositis after 2 cycles of second-line nivolumab. Read More

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http://dx.doi.org/10.21037/tlcr.2020.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225145PMC

COVID 19: Neuromuscular Manifestations.

Ann Indian Acad Neurol 2020 Apr 21;23(Suppl 1):S40-S42. Epub 2020 Apr 21.

Dean, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

COVID-19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. Neuromuscular manifestations have been reported uncommonly in these early stages of the analysis. This manuscript studies the available information on the neuromuscular manifestations of COVID-19. Read More

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http://dx.doi.org/10.4103/aian.AIAN_309_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213035PMC

The Diagnostic Value of MR IVIM and T2 Mapping in Differentiating Autoimmune Myositis From Muscular Dystrophy.

Acad Radiol 2020 May 13. Epub 2020 May 13.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Road, Wuhan 430030, Hubei Province, People's Republic of China. Electronic address:

Rationale And Objectives: To confirm the feasibility and compare the accuracy of magnetic resonance imaging intravoxel incoherent motion (IVIM) and T2 mapping models for the differentiation of autoimmune myositis from muscular dystrophy.

Materials And Methods: Fourty-two autoimmune myositis and 11 muscular dystrophy patients proven by diagnostic criteria were enrolled in the study. Conventional MR sequences, IVIM, and T2 mapping through the bilateral thighs were obtained as well as blood samples for all patients. Read More

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http://dx.doi.org/10.1016/j.acra.2020.04.022DOI Listing

Lessons of the month: Herpetic viral dermatomyositis.

Clin Med (Lond) 2020 May;20(3):e12-e14

Aster Medcity, Kochi, India.

We present the case of a man who presented with severe left lower back pain radiating to the anterior aspect of left thigh. He also had fever and headache. Due to the exquisite tenderness along the inguinal region, the possibility of a psoas abscess was considered. Read More

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http://dx.doi.org/10.7861/clinmed.2020-0078DOI Listing

The promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis.

Arthritis Res Ther 2020 May 15;22(1):117. Epub 2020 May 15.

University of Bath, Bath, UK.

Background: A myositis-specific autoantibody can now be identified in the majority of patients with myositis. They identify homogeneous patient subgroups and are key tools in developing a personalized approach to disease management. There is substantial clinical interest in exploiting myositis autoantibodies as biomarkers, and consequently, a large number of commercial assays have been developed for their detection. Read More

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http://dx.doi.org/10.1186/s13075-020-02210-2DOI Listing

Mitochondrial Dysfunction: A Common Hallmark Underlying Comorbidity between sIBM and Other Degenerative and Age-Related Diseases.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain.

Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy associated, among others, with mitochondrial dysfunction. Similar molecular features are found in Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM), underlying potential comorbidity. This study aims to evaluate common clinical and molecular hallmarks among sIBM, AD, and T2DM. Read More

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http://dx.doi.org/10.3390/jcm9051446DOI Listing

A Single Amino Acid Replacement in Penicillin Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness upon Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis.

Am J Pathol 2020 May 11. Epub 2020 May 11.

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA; Clinical Microbiology Laboratory, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA. Electronic address:

Invasive strains of Streptococcus pyogenes with significantly reduced susceptibility to beta-lactam antibiotics have been recently described. These reports have caused considerable concern in the international infectious disease, medical microbiology, and public health communities because S. pyogenes has remained universally susceptible to beta-lactam antibiotics for 70 years. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.04.014DOI Listing

Rheumatic Manifestations in Patients Treated with Immune Checkpoint Inhibitors.

Int J Mol Sci 2020 May 11;21(9). Epub 2020 May 11.

Department of Rheumatology, Patras University Hospital, University of Patras Medical School, 26500 Patras, Greece.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate the immune system, aiming at enhancing antitumor immunity. Their clinical efficacy is well-documented, but the side effects associated with their use are still under investigation. These drugs cause several immune-related adverse events (ir-AEs), some of which stand within the field of rheumatology. Read More

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http://dx.doi.org/10.3390/ijms21093389DOI Listing

Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases.

Expert Opin Biol Ther 2020 May 13:1-11. Epub 2020 May 13.

Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: the migration of monocytes and cytotoxic effector T cells, the proliferation and activation of fibroblast-like synoviocytes, angiogenesis, and osteoclastogenesis. Read More

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http://dx.doi.org/10.1080/14712598.2020.1764931DOI Listing

Statin Intolerance, anti-HMGCR Antibodies, and Immune Checkpoint Inhibitor-Associated Myositis: A "Two-Hit" Autoimmune Toxicity or Clinical Predisposition?

Oncologist 2020 May 13. Epub 2020 May 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Immune-related adverse events induced by immune checkpoint inhibitor (ICI) therapy may affect diverse organ systems, including skeletal and cardiac muscle. ICI-associated myositis may result in substantial morbidity and occasional mortality. We present a case of a patient with advanced non-small cell lung cancer who developed grade 4 myositis with concurrent myocarditis early after initiation of anti-programmed death ligand 1 therapy (durvalumab). Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0911DOI Listing
May 2020
4.865 Impact Factor

Lung involvement associated with anti-NXP2 autoantibodies in inflammatory myopathies: a French monocenter series.

Expert Rev Respir Med 2020 May 12. Epub 2020 May 12.

Assistance Publique Hôpitaux de Marseille. Hôpital Nord. Service de Pneumologie, Centre de Compétence national des maladies pulmonaires rares, Marseille, France.

: Idiopathic inflammatory myopathies (IIM) are characterized by muscular inflammation that can be associated with systemic disorders including lung. Anti-NXP2 antibody is a rare myositis-specific antibody and its association with pulmonary involvement is still unknown. In this study we investigated the characteristics of lung disease in patients with IMM associated with anti-NXP2 Ab. Read More

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http://dx.doi.org/10.1080/17476348.2020.1767598DOI Listing

Immune checkpoint inhibitors (ICIs)-related ocular myositis.

Neuromuscul Disord 2020 Feb 26. Epub 2020 Feb 26.

Department of Neuroscience, San Camillo-Forlanini Hospital, Rome, Italy.

We present extensive clinical, serological, morphological and muscle imaging data of a 66-year-old man with isolated bilateral ptosis and external ophthalmoplegia secondary to Immune checkpoint inhibitors (Pembrolizumab). He had elevated CK level (>5000 UI/L). No facial, bulbar, proximal, distal or axial muscular weakness was observed. Read More

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http://dx.doi.org/10.1016/j.nmd.2020.02.013DOI Listing
February 2020

Performance evaluation of a commercial line blot assay system for detection of myositis- and systemic sclerosis-related autoantibodies.

Clin Rheumatol 2020 May 8. Epub 2020 May 8.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

Introduction/objectives: A line blot (LB) assay is a multi-analyte platform capable of simultaneously detecting multiple anti-nuclear antibody specificities. Here, we evaluated the performance of a commercial LB assay developed for the identification of myositis- or systemic sclerosis (SSc)-related autoantibodies (autoAbs).

Method: We screened 300 serum samples from patients with various connective tissue diseases using an LB assay and compared the results of myositis- or SSc-related autoAbs with those identified by RNA and protein immunoprecipitation (IP) assays or indirect immunofluorescence (IIF). Read More

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http://dx.doi.org/10.1007/s10067-020-04973-0DOI Listing

[Myasthenia Gravis and Myositis(PD-1 Myopathy)].

Authors:
Shigeaki Suzuki

Gan To Kagaku Ryoho 2020 Feb;47(2):219-223

Dept. of Neurology, Keio University School of Medicine.

The specific characteristics of neuromuscular immune-related adverse events(irAEs)including myasthenia gravis have not been elucidated because the frequency is generally low, ranging from 1-2% of cancer patients undergoing therapy with programmed cell death 1(PD-1)inhibitors. Inflammatory myopathy(myositis)is also one of the representative neuromuscular irAEs. A variety of studies have demonstrated that myositis as an irAE is often accompanied by ocular muscle symptoms, which physicians have often termed "myasthenia-like" or "pseudo-myasthenic". Read More

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February 2020

Anaplastic lymphoma kinase inhibitor-associated myositis.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 6;7(4). Epub 2020 May 6.

From the Department of Neuropathology (A.U., S.S., C.D., H.-H.G., W.S.), Charité-Universitätsmedizin, Berlin; Department of Radiology (S.K.), Carl-Thiem-Klinikum Cottbus; Department of Neuropathology (H.-H.G.), Universitätsmedizin Mainz; Department of Neurology (A.D., R.H.), Carl-Thiem-Klinikum Cottbus; and Leibniz Science Campus Chronic Inflammation (W.S.), Berlin, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000735DOI Listing

Case Report: Dengue Virus-Triggered Parkinsonism in an Adolescent.

Am J Trop Med Hyg 2020 May 4. Epub 2020 May 4.

Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India.

Dengue fever continues to be an important cause of morbidity and mortality in tropical and subtropical countries. A wide range of neurological manifestations including dengue encephalopathy, Guillain-Barre syndrome, acute disseminated encephalomyelitis, transverse myelitis, cranial nerve palsies, and myositis have been reported following dengue infection. But parkinsonism secondary to dengue virus infection is uncommon, with only three published case reports in adults and one in children. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0039DOI Listing
May 2020
2.699 Impact Factor

Temporal relationship between idiopathic inflammatory myopathies and malignancies and its mortality: a nationwide population-based study.

Clin Rheumatol 2020 May 5. Epub 2020 May 5.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.

Objectives: To examine the temporal relationship between malignancies and idiopathic inflammatory myopathies (IIMs) and its impact on mortality.

Methods: A retrospective cohort for IIM patients was conducted using the Korean National Health Insurance Service databases. We observed more than 5 years before and after the diagnosis of IIM (2002~2016) to identify IIM patients who developed any malignancy and classified these patients into two groups: the cancer-associated myositis (CAM) group, who developed malignancy within 3 years before or after the diagnosis of IIM and the cancer-not-associated myositis (CNAM) group, who developed malignancy beyond 3 years of IIM onset. Read More

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http://dx.doi.org/10.1007/s10067-019-04782-0DOI Listing

Myositis from intramuscular oil injections in a bodybuilder.

CMAJ 2020 May;192(18):E480

Cumming School of Medicine, Department of Medicine (Prosperi-Porta, Oleynick, Vaughan), University of Calgary, Calgary, Alta.; Division of Infectious Diseases, Department of Medicine (Vaughan), Foothills Medical Centre, Calgary, Alta.

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http://dx.doi.org/10.1503/cmaj.191500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207174PMC

Inclusion Body Myositis. Genetics, Biomarkers and Muscle Biopsy.

Int J Neurosci 2020 May 4:1-10. Epub 2020 May 4.

Third Department of Neurology, Aristotle University of Thessaloniki, Greece.

Sporadic inclusion body myositis is the most common idiopathic inflammatory myopathy over the age of 50, with a male-to-female ratio of 3:1. Symptoms onset before age of 60 occurs in 18-20% of patients, with a delay in diagnosis of 5 to 8 years.The classic clinical presentation of SIBM consists of proximal leg and distal arm weakness, and most commonly patients present early slowly progressive quadriceps weakness which leads to falls and to difficulties in climbing stairs, while less common the initial complaints refer to finger flexor weakness and atrophy, foot drop, or dysphagia, and rare presentations include prominent forearm weakness, sparing the quadriceps. Read More

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http://dx.doi.org/10.1080/00207454.2020.1763340DOI Listing

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies.

Front Cell Dev Biol 2020 17;8:226. Epub 2020 Apr 17.

Experimental Therapeutics Laboratory, University of South Australia Cancer Research Institute, Adelaide, SA, Australia.

Introduction: High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM).

Methods: Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes using immunohistochemistry and ELISA. Read More

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http://dx.doi.org/10.3389/fcell.2020.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180187PMC

Fibro-osseous Pseudotumor of the Toe.

Eplasty 2020 22;20:ic2. Epub 2020 Feb 22.

Department of Oral and Maxillofacial Surgery and Plastic Surgery.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180200PMC
February 2020

The assessment of patients with the antiphospholipid antibody syndrome: where are we now?

Rheumatology (Oxford) 2020 May 1. Epub 2020 May 1.

Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK.

The antiphospholipid antibody syndrome (APS), a chronic autoimmune thrombophilia with an increased mortality and morbidity, has been recognized for more than three decades. Unlike other autoimmune rheumatic conditions such as systemic lupus erythematosus, myositis and Sjögren's syndrome, relatively few attempts have been made to develop activity, damage or disease-specific quality of life indices for APS. In this review of the literature, we consider those attempts that have been made to develop assessment tools for patients with APS, but also reflect upon the nature of the condition, to discuss, in particular, whether an activity index is appropriate for this disease. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa172DOI Listing

Immune Checkpoint Inhibitor-Related Myositis: From Biology to Bedside.

Int J Mol Sci 2020 Apr 26;21(9). Epub 2020 Apr 26.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, 70124 Bari, Italy.

Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. Read More

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http://dx.doi.org/10.3390/ijms21093054DOI Listing

Macrophage activation syndrome in adult dermatomyositis: a case-based review.

Rheumatol Int 2020 Apr 30. Epub 2020 Apr 30.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases, characterized by fever, hepatosplenomegaly, and pancytopenia. Dermatomyositis (DM) is one of the causes of MAS; however, its clinical characteristics in DM patients remain unclear. This study aimed to present a case of anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM complicated by MAS in a 29-year-old woman and to review the literatures including similar cases. Read More

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http://dx.doi.org/10.1007/s00296-020-04590-9DOI Listing

Bar None: A Rare Cause of Oropharyngeal Dysphagia.

Dig Dis Sci 2020 Jun;65(6):1656-1660

Divisions of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.

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http://dx.doi.org/10.1007/s10620-020-06274-7DOI Listing

Nailfold Videocapillaroscopy is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients.

Diagnostics (Basel) 2020 Apr 25;10(5). Epub 2020 Apr 25.

Regional Referral Centre for Rare Lung Diseases, A. O. U. "Policlinico-Vittorio Emanuele" Dept. Of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud's phenomenon (RP) as possibly associated with systemic sclerosis (SSc). Recent insights have also highlighted its role in the diagnostic assessment of idiopathic inflammatory myopathies (IIMs). The aim of this study is to describe the diagnostic role of NVC in a series of 361 consecutive patients with interstitial lung disease (ILD). Read More

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http://dx.doi.org/10.3390/diagnostics10050253DOI Listing

An MRI study of immune checkpoint inhibitor-induced musculoskeletal manifestations myofasciitis is the prominent imaging finding.

Rheumatology (Oxford) 2020 May;59(5):1041-1050

Department of Rheumatology, University of Patras Medical School, Patras, Greece.

Objective: To assess: (i) the prevalence, and clinical and imaging characteristics of immune checkpoint inhibitor (ICI)-induced musculoskeletal immune-related adverse events (ir-AEs) in a prospective manner and (ii) whether serum levels of cytokines associated with the Th1/Th2/Th17 response are differentially expressed in patients with and without musculoskeletal Ir-AEs.

Methods: All patients treated with ICI who developed musculoskeletal manifestations were referred to the Rheumatology Department, and an MRI of the involved area(s) was performed.

Results: During the study period, a total of 130 patients were treated with ICIs. Read More

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http://dx.doi.org/10.1093/rheumatology/kez361DOI Listing

Fibrodysplasia ossificans progressiva-a rare disease with distinctive features yet still a diagnostic challenge: A case report.

Medicine (Baltimore) 2020 Apr;99(17):e19933

Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University and VA Portland Health Care System, Portland, OR.

Rationale: Fibrodysplasia ossificans progressiva (FOP) is rare genetic disease featuring progressive heterotopic ossification of soft tissues of the musculoskeletal system which leads to severe disability and premature death. Recognition of this disease is important since invasive diagnostic procedures can promote disease progression. However, despite its distinctive clinical manifestations, diagnosis can be difficult because of its rarity PATIENT CONCERNS:: A 20-year-old woman was referred to rheumatology clinic for management of "ankylosing spondylitis". Read More

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http://dx.doi.org/10.1097/MD.0000000000019933DOI Listing

Radiation Recall Myositis Detected With 18F-FDG PET/CT After a Treatment of Cervical Cancer.

Clin Nucl Med 2020 Apr 21. Epub 2020 Apr 21.

From the Departments of Nuclear Medicine and Radiobiology.

A 34-year-old woman, after being treated for cervical cancer, presented with severe pain in the inguinal and the upper abdominal region with restriction in range of motion of the trunk 71 days after radiation therapy and 19 days after receiving adjuvant gemcitabine and cisplatin chemotherapy. The F-FDG PET/CT showed complete response to cancer treatment, but also revealed a localized inflammatory process that was delimited by radiation fields rather than anatomical structures, suggesting a radiation recall phenomenon. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003024DOI Listing

Ovoid palatal patch: a clue to anti-TIF1γ dermatomyositis.

BMJ Case Rep 2020 Apr 23;13(4). Epub 2020 Apr 23.

Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Read More

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http://dx.doi.org/10.1136/bcr-2019-234111DOI Listing

Myositis as a manifestation of SARS-CoV-2.

Ann Rheum Dis 2020 Apr 23. Epub 2020 Apr 23.

Department of Rheumatology, Bicetre Hospital, Le Kremlin-Bicêtre, France

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http://dx.doi.org/10.1136/annrheumdis-2020-217573DOI Listing

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.

Ann Rheum Dis 2020 Apr 23. Epub 2020 Apr 23.

Rheumatology, University Hospital of Bordeaux, Bordeaux, France.

Background: Rheumatic and musculoskeletal immune-related adverse events (irAEs) are observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs). Given the recent emergence of these events and the lack of guidance for rheumatologists addressing them, a European League Against Rheumatism task force was convened to harmonise expert opinion regarding their identification and management.

Methods: First, the group formulated research questions for a systematic literature review. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217139DOI Listing

Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy.

Vet Sci 2020 Apr 21;7(2). Epub 2020 Apr 21.

Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina (ME), Italy.

Infectious causes of myositis are reported relatively uncommonly in horses. Among them, bacterial causes include subsp. , , spp. Read More

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http://dx.doi.org/10.3390/vetsci7020047DOI Listing

Clinical Features of Ocular Motility in Idiopathic Orbital Myositis.

J Clin Med 2020 Apr 18;9(4). Epub 2020 Apr 18.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 13620, Korea.

Objective: To elucidate the clinical features of ocular motility and the risk factors for recurrence in idiopathic orbital myositis.

Methods: The medical records of 31 patients diagnosed with idiopathic orbital inflammation between 2003 and 2019 were retrospectively reviewed. All patients were initially treated with corticosteroids. Read More

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http://dx.doi.org/10.3390/jcm9041165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231042PMC

[Antinuclear antibodies in systemic autoimmune disease].

Ned Tijdschr Geneeskd 2020 Apr 23;164. Epub 2020 Apr 23.

Erasmus MC, afd. Immunologie, Rotterdam.

Diagnosis of systemic autoimmune diseases, including systemic lupus erythematosus (SLE), can be supported by detection of antinuclear antibodies (ANA). Additional support may be provided by detecting antibodies against double-stranded (ds) DNA, standard extractable nuclear antigens (ENA) or certain disease-specific antigen combinations, including a myositis panel for idiopathic inflammatory myopathy (IIM). The detection of ANA has classically been effected by indirect immunofluorescence (IIF) analysis of patient serum using HEp-2 cells. Read More

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A bump in the neck. Myositis ossificans of the omohyoid muscle: Imaging findings.

Clin Ter 2020 May-Jun;171(3):e185-e188

Sezione di Scienze radiologiche - BIND, Università degli Studi di Palermo.

Myositis ossificans is a benign ossifying soft-tissue mass that occurs in muscle. In the majority of cases it is related to trauma but rarely observed in the neck. A 54 year-old-man with history of minor trauma and anticoagulant drug assumption for V Leiden mutation, was referred to our institution for a painless mass in the right supraclavicular fossa. Read More

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http://dx.doi.org/10.7417/CT.2020.2211DOI Listing

Oedematous myositis: a clinical presentation first suggesting dermatomyositis diagnosis.

Brain Pathol 2020 Apr 22. Epub 2020 Apr 22.

Department of Internal Medicine and Clinical Immunology, National Reference Center of Neuromuscular disorders, APHP, Pitié-Salpêtrière University Hospital, Sorbonne University, University Pierre et Marie Curie, Paris, France.

Aims: Oedema of the limbs is uncommon in idiopathic inflammatory myopathies (IIM). The few reported cases have been associated with severe and refractory dermatomyositis (DM), sometimes in association with cancers. We aimed to determine if oedematous myositis is a homogeneous subtype based on clinical, serological and pathological features. Read More

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http://dx.doi.org/10.1111/bpa.12844DOI Listing

The clinical phenotype associated with antisynthetase autoantibodies.

Reumatologia 2020 28;58(1):4-8. Epub 2020 Feb 28.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Objectives: Specific systemic autoimmune syndrome characterized by inflammatory myopathy, arthritis or arthralgias, interstitial lung disease (ILD), fever, Raynaud's phenomenon, and mechanic's hands is called antisynthetase syndrome (AS). The aim of this study was to assess the clinical spectrum associated with presence of aminoacyl-transfer RNA synthetase autoantibodies (ASA).

Material And Methods: A total of 305 patients with presence of myositis-specific autoantibodies were identified in the database of immunological tests performed in the Clinical Immunology and Transplantology Unit, Medical University of Gdansk between January 2011 and March 2016. Read More

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http://dx.doi.org/10.5114/reum.2020.93505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174798PMC
February 2020

DIVING INTO THE HETEROGENEITY OF INCLUSION BODY MYOSITIS.

Authors:
Hani Kushlaf

Muscle Nerve 2020 Apr 21. Epub 2020 Apr 21.

Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, United States.

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http://dx.doi.org/10.1002/mus.26897DOI Listing

A Case of Dermatomyositis Along with Esophageal Cancer and Screening of Serum Transcriptional Intermediary Factor 1 Gamma Antibodies in Various Cancer Patients.

Am J Case Rep 2020 Apr 21;21:e922004. Epub 2020 Apr 21.

Department of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo, Japan.

BACKGROUND Dermatomyositis (DM) is occasionally associated with malignancy, which is so-called cancer-associated myositis. The cancer screening in patients with dermatomyositis is an important clinical issue. That is because malignant disease underlying dermatomyositis is potentially life-threatening. Read More

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http://dx.doi.org/10.12659/AJCR.922004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193243PMC

Association of Dermatomyositis Sine Dermatitis and With Anti-Nuclear Matrix Protein 2 Autoantibodies.

JAMA Neurol 2020 Apr 20. Epub 2020 Apr 20.

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Importance: Reports on dermatomyositis (DM) sine dermatitis (DMSD) are scarce, and the concept of the disease has not been widely accepted.

Objective: To confirm the existence of DMSD, determine its prevalence, and characterize its serologic features.

Design, Setting, And Participants: This is a cohort study that reviewed clinical information, laboratory data, and muscle pathology slides from January 2009 to August 2019. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.0673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171574PMC