21,618 results match your criteria Infectious Myositis


Intravenous human immunoglobulin and/or methylprednisolone pulse therapies as a possible treat-to-target strategy in immune-mediated necrotizing myopathies.

Rheumatol Int 2019 Feb 18. Epub 2019 Feb 18.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

To evaluate the relevance of immunoglobulin (IVIg) and/or methylprednisolone pulse therapies in immune-mediated necrotizing myopathy (IMNM). Secondarily, to analyze the muscle damage measured by late magnetic resonance images (MRI). This retrospective study included 13 patients with defined IMNM (nine patients positive for the anti-signal recognition particle and four patients positive for hydroxyl-methyl-glutaryl coenzyme A reductase) who were followed from 2012 to 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-019-04254-3DOI Listing
February 2019

OMERACT 2018 Modified Patient-reported Outcome Domain Core Set in the Life Impact Area for Adult Idiopathic Inflammatory Myopathies.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Learning, Informatics and Medical Education, Karolinska Institutet; Function Area Occupational Therapy and Physical Therapy, Allied Health Professionals Function, Karolinska University Hospital, Department of Neurobiology, Care Science and Society, Division of Physiotherapy and Department of Medicine, Karolinska Institutet; Division of Rheumatology, Rheumatology Unit, Department of Medicine, Karolinska Institutet, Solna, Sweden; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Division of Rheumatology, Department of Internal Medicine, Medical Research Center, College of Medicine, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea; Division of Rheumatology, Fiona Stanley Hospital, Institute for Immunology and Infectious Diseases, Murdoch University, Perth; The Notre Dame University Fremantle, Fremantle, Australia; Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, the Netherlands; Center for Global Health, University of Ottawa, Ottawa, Ontario, Canada. Support for this project comes from a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1277); The Swedish Rheumatism Association; The Börje Olhagen foundation (supported by grants provided by the Stockholm County Council ALF project); the Diplomat Specialty Infusion Group; Option Care; and Nufactor Inc. M. Regardt, PhD, Occupational Therapist, Department of Learning, Informatics and Medical Education, Karolinska Institutet, and Function Area Occupational Therapy and Physical Therapy, Allied Health Professionals Function, Karolinska University Hospital; C.A. Mecoli, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; J.K. Park, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital; I. de Groot, Patient Research Partner; C. Sarver, Patient Research Partner; M. Needham, MD, Division of Rheumatology, Fiona Stanley Hospital, Institute for Immunology and Infectious Diseases, Murdoch University, and The Notre Dame University; M. de Visser, MD, PhD, Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience; B. Shea, MSN, Center for Global Health, University of Ottawa; C.O. Bingham III, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; I.E. Lundberg, MD, PhD, Division of Rheumatology, Rheumatology Unit, Department of Medicine, Karolinska Institutet; Y.W. Song, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Medical Research Center, College of Medicine, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University; L. Christopher-Stine, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; H. Alexanderson, PhD, Physiotherapist, Department of Neurobiology, Care Science and Society, Division of Physiotherapy and Department of Medicine Solna, Karolinska Institutet, and Function Area Occupational Therapy and Physical Therapy, Allied Health Professionals Function, Karolinska University Hospital. M. Regardt and Dr. C. Mecoli are co-first authors. Address correspondence to M. Regardt, Function Area Occupational Therapy and Physical Therapy, Karolinska University Hospital, Department of LIME, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden. E-mail: Accepted for publication December 21, 2018.

Objective: To present and vote on a myositis modified patient-reported outcome core domain set in the life impact area at the Outcome Measures in Rheumatology (OMERACT) 2018.

Methods: Based on results from international focus groups and Delphi surveys, a draft core set was developed.

Results: Domains muscle symptoms, fatigue, level of physical activity, and pain reached ≥ 70% consensus and were mandatory to assess in all trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.181065DOI Listing
February 2019
1 Read

Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease.

Arthritis Res Ther 2019 Feb 14;21(1):58. Epub 2019 Feb 14.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Background: Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstitial lung disease (CTD-ILD). This study aimed to evaluate Krebs von den Lungen 6 (KL-6) as a potential biomarker reflecting the severity of CTD-ILD as assessed through computed tomography (CT) and pulmonary function test (PFT) parameters.

Methods: This retrospective study included 549 Korean patients with rheumatoid arthritis, systemic sclerosis, inflammatory myositis, and other CTDs with or without concurrent ILD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-019-1835-9DOI Listing
February 2019
1 Read

Sonographic assessment of musculoskeletal causes of calf pain and swelling.

Emerg Radiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic Radiology, Woodlands Health Campus, 2 Yishun Central 2, Tower E, Level 5, Singapore, 768024, Republic of Singapore.

Calf pain or swelling is a common presentation to the emergency department. The differential diagnoses are wide. Deep vein thrombosis (DVT) is often the first diagnosis to be excluded given its potentially fatal complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10140-019-01680-5DOI Listing
February 2019
1 Read

[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

The National Institute for Health Research Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS FoundationTrust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Objectives: With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could differentiate between IBM and PM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214644DOI Listing
February 2019

Association between TDP-43 and mitochondria in inclusion body myositis.

Lab Invest 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

Inclusion body myositis (IBM) is the most common cause of primary myopathy in individuals aged 50 years and over, and is pathologically characterized by protein aggregates of p62 and mislocalized cytoplasmic TDP-43, as well as mitochondrial abnormalities in affected muscle fibers. Our recent studies have shown the accumulation of TDP-43 in mitochondria in neurons from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), and revealed mitochondria as critical mediators of TDP-43 neurotoxicity. In this study, we investigated the association between mitochondria and TDP-43 in biopsied skeletal muscle samples from IBM patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-019-0233-xDOI Listing
February 2019
2 Reads

Parvimonas micra Spondylodiscitis: A Case Report and Systematic Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):67-71

Department of Orthopaedic Surgery, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

Introduction: Treatment and risk factors for Parvimonas micra spinal infections are scarcely researched. This study reports a case and presents a systematic review of the literature to provide evidence-based ground for diagnosis and treatment of P. micra spinal infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13107/jocr.2250-0685.1216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367290PMC
February 2019
8 Reads

A Case of Fibrodysplasia Ossificans Progressiva in a 5-year-old Boy with all Musculoskeletal Features and Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):36-39

Department of Medical Genetics, Istanbul University, Istanbul School of Medicine, Sehremini, Fatih, Istanbul, Turkey.

Introduction: Fibrodysplasia ossificans progressiva previously known as myositis ossificans progressiva is a rare connective tissue disorder with autosomal dominant genetic inheritance. Patients develop heterotrophic ossification starting with the first decade of life. Diagnosis is extremely difficult until ossifications are visible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13107/jocr.2250-0685.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367301PMC
February 2019

Statins, myalgia, and rhabdomyolysis.

Authors:
Anne Tournadre

Joint Bone Spine 2019 Feb 5. Epub 2019 Feb 5.

Service de rhumatologie, CHU Clermont-Ferrand, Hôpital G Montpied, 63003 Clermont-Ferrand, France; Unité de Nutrition Humaine, UMR1019 INRA/Université Clermont Auvergne, 63000 Clermont-Ferrand, France. Electronic address:

Statin-associated muscle symptoms (SAMSs) vary considerably in frequency and severity, with a spectrum extending from myalgia with normal creatine kinase (CK) levels or asymptomatic hyperCKemia to potentially life-threatening rhabdomyolysis and necrotizing autoimmune myopathy. Myalgia with CK elevation is the most common presentation. Onset is usually within 1 month after statin initiation or dosage intensification, and the symptoms can be expected to resolve within a few weeks after treatment discontinuation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.01.018DOI Listing
February 2019
1 Read

(Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: (Aves: Picidae).

Int J Parasitol Parasites Wildl 2019 Apr 24;8:106-110. Epub 2018 Dec 24.

INIBIOMA (CONICET-Universidad Nac. del Comahue), Departamento de Zoología-CRUB, 8400, Bariloche, Argentina.

We describe pathological aspects of an infection caused by parasitic nematodes in skeletal muscles of a Magellanic woodpecker (), providing the first description of any disease findings in this species. A weakened female with locomotory dysfunction was rescued near Bariloche city (Argentine Patagonia), which soon died. At the necropsy, unexpected masses of tissue were located at three joints (legs and tail). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijppaw.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357897PMC

Combining immunofluorescence with immunoblot assay improves the specificity of autoantibody testing for myositis.

Rheumatology (Oxford) 2019 Feb 4. Epub 2019 Feb 4.

Laboratorio di Patologia Clinica, Ospedale San Antonio, Tolmezzo, Italy.

Objective: Immunoblot (IB) methods are widely used to detect myositis-specific autoantibodies (MSAs); however, false-positive results are common. In this study, we aimed to determine whether associating the anti-nuclear antibody (ANA) IIF pattern may help to improve the specificity of MSA detection by IB in patients with idiopathic inflammatory myositis (IIM).

Methods: Serum samples from 104 patients presenting with muscle weakness/myalgia and positive to at least one MSA by IB (MYOS12 Diver and MIOS7 Diver, D-tek) were tested for ANAs on HEp-2000 cells (Immuno Concepts). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/key451DOI Listing
February 2019

Yoga-Induced Myositis Ossificans Traumatica of the Scapholunate Ligament.

J Wrist Surg 2019 Feb 26;8(1):80-83. Epub 2018 Jun 26.

Department of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, California.

 Myositis ossificans traumatica (MOT) involves the heterotopic development of lamellar bone after a traumatic injury. Despite being termed "myositis," MOT is not limited to muscle but rather can involve tendons, fat, and fascia. "Traumatica" reflects that lesions are usually associated with a history of significant trauma, that is, fractures or surgery; however, many reports suggest they can also be linked to repetitive low-energy insults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1661354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358443PMC
February 2019
1 Read

Outcomes of Pregnancy in Women With Inflammatory Myositis: A Retrospective Cohort From India.

J Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objectives: Idiopathic inflammatory myositis (IIM) commonly affects women in the childbearing age group. Both disease activity and immunosuppressants used may have adverse effects on fertility and outcomes of pregnancy. We explored these outcomes in a retrospective cohort of women with IIM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000000996DOI Listing
February 2019
3 Reads

Cardiovascular Toxicities Associated with Immune Checkpoint Inhibitors.

Cardiovasc Res 2019 02 2. Epub 2019 Feb 2.

Division of Cardiology, Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN, USA.

Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in case series but have been underappreciated due to difficulties in diagnosis and non-specific clinical manifestations. ICIs are antibodies that block negative regulators of the T cell immune response, including cytotoxic T-lymphocyte associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and PD-1 ligand (PD-L1). While ICIs have introduced a significant mortality benefit in several cancer types, the augmented immune response has led to a range of immune-related toxicities, including cardiovascular toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvz026DOI Listing
February 2019
1 Read
5.940 Impact Factor

Responsiveness to Change of 5-point MRC scale, Endurance and Functional Evaluation for Assessing Myositis in Daily Clinical Practice.

J Neuromuscul Dis 2019 ;6(1):99-107

Department of Internal Medicine and Clinical Immunology, National Reference Center of Neuromuscular disorders, Pitié-Salpêtrière University Hospital, Sorbonne Université, Paris, France.

Background: Manual muscle testing has been widely used for the evaluation of muscle strength in myositis, yet less attention has been devoted to the evaluation of muscle function and endurance.

Objective: Our objective was therefore to compare the responsiveness to change of muscle strength, endurance and functional testing following induction therapy for severe myositis flare (requiring high-dose corticosteroids and combined immunotherapy) in patients with a diagnosis of dermatomyositis, immune-mediated necrotizing myopathy, or overlap myositis.

Methods: Muscle status was assessed at baseline and after mean 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JND-180358DOI Listing
January 2019
2 Reads

Strategy for Suspected Myositis.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France; Centre de Référence des Maladies Autoimmunes Rares de l'Est & Sud Ouest, 33000 Bordeaux, France; Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, 67081 Strasbourg, France.

Skeletal muscle inflammation is the feature shared by all forms of myositis. However, the muscle damage ranges in severity from asymptomatic to responsible for severe weakness. In addition, myositis usually occurs as a systemic disease that affects multiple organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.01.013DOI Listing
January 2019
1 Read

Fibro-osseous pseudotumor on the hyponychium of the great toe.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

The University of Texas McGovern Medical School at Houston, Houston, Texas.

Fibro-osseous pseudotumor of the toe is a benign soft tissue tumor that is predominant in the young adult population. Although the etiology is unknown, a history of trauma has been reported to precede tumor development. The differential diagnosis includes myositis ossificans, extraskeletal osteosarcoma, and pyogenic granuloma. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Juvenile idiopathic inflammatory myopathies: A clinicopathological study with emphasis on muscle histology.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):61-66

Department of Neurology, Institute of Neurological Sciences, Care Hospital, Hyderabad, Telangana, India.

Background: Juvenile idiopathic inflammatory myopathies (JIIM) are rare and heterogeneous. Subtype identification is important for treatment.

Materials And Methods: Patients below 18 years diagnosed as idiopathic inflammatory myopathy (IIM) according to the Bohan and Peter criteria between January 2010 and May 2015 were evaluated with muscle biopsy in the four domains: muscle fiber, inflammation, connective tissue, and vascular, with basic panel of histochemical stains as per recommendations of the European Neuromuscular center (ENMC) workshop 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_387_17DOI Listing
February 2019
1 Read

Ceftaroline Plus Daptomycin for Refractory Methicillin- Resistant Staphylococcus aureus Bacteremia in a Child.

J Pediatr Pharmacol Ther 2018 Nov-Dec;23(6):490-493

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be difficult to treat, with growing adult literature supporting the combination of ceftaroline and daptomycin for these patients. Here, we report a pediatric patient with persistent MRSA bacteremia with associated cellulitis, fasciitis, myositis, and a deep venous thrombosis causing septic pulmonary emboli. After being unable to clear the bacteremia on vancomycin and then daptomycin monotherapy, the bacteremia cleared quickly with rapid clinical improvement after the addition of ceftaroline to daptomycin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5863/1551-6776-23.6.490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336175PMC
January 2019
1 Read

[Muscular polyarteritis nodosa-a case-based review].

Z Rheumatol 2019 Jan 29. Epub 2019 Jan 29.

Rheumatologie, Klinische Immunologie, Nephrologie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Background: Myalgia is a common but unspecific set of symptoms that may be caused by orthopedic, neurological and internal medical conditions, often resulting in a diagnostic challenge. Muscular polyarteritis nodosa (PAN) is a rare differential diagnosis of myalgia with elevated serological inflammatory markers.

Objective: Based on three clinical cases and the literature this review describes the essential clinical and diagnostic features of muscular PAN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00393-019-0595-xDOI Listing
January 2019
1 Read

A Descriptive Study of Lectin Histochemistry of the Placenta in Cattle following Inoculation of Neospora caninum.

J Comp Pathol 2019 Jan 1;166:45-53. Epub 2018 Dec 1.

Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.

The aim of this study was to describe the lectin-binding pattern in the placentas of cows infected experimentally with Neospora caninum. Four cows were inoculated intravenously with 1 × 10 tachyzoites of the NC-1 strain of N. caninum at 150 ± 7 days of pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcpa.2018.10.172DOI Listing
January 2019
1 Read

Efficacy and safety of rituximab in anti-synthetase antibody positive and negative subjects with idiopathic inflammatory myopathy: a registry-based study.

Rheumatology (Oxford) 2019 Jan 25. Epub 2019 Jan 25.

Division of Rheumatology, Department of Medicine, Solna, and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Objective: Post-hoc analyses of the Rituximab in Myositis trial indicate that specific autoantibodies profiles may influence treatment response. We compared the efficacy and safety of rituximab in anti-synthetase antibody (ARS-ab) positive and negative patients.

Methods: Adult idiopathic inflammatory myopathy (IIM) subjects in the Swedish Rheumatology Quality Register who received ⩾ 1 cycle of rituximab were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/key450DOI Listing
January 2019
1 Read

Severe Thrombocytopenia in Patient with Dermatomyositis.

Curr Health Sci J 2018 Apr-Jun;44(2):192-196. Epub 2018 Mar 27.

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania.

Dermatomyositis (DM) is part of a heterogeneous group of systemic diseases called idiopathic inflammatory myopathies. As in other autoimmune connective tissue diseases (CTD), abnormalities of hematopoietic tissue and/or peripheral blood cells may develop and represent an important prognostic factor. Most common CTD associated with thrombocytopenia (TP) are systemic lupus erythematosus and antiphospholipid syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.02.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320470PMC
March 2018
1 Read

Pro-inflammatory S100A11 is elevated in inflammatory myopathies and reflects disease activity and extramuscular manifestations in myositis.

Cytokine 2019 Apr 23;116:13-20. Epub 2019 Jan 23.

Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Background: S100A11 (calgizzarin), a member of the S100 family, is associated with oncogenesis, inflammation and myocardial damage. Our aim was to analyse S100A11 in idiopathic inflammatory myopathies (IIMs) and its association with disease activity features and cancer development.

Methods: S100A11 in muscle was determined by immunohistochemistry in polymyositis (PM), dermatomyositis (DM), myasthenia gravis (MG) and in subjects without autoimmune inflammatory disease (HC). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10434666193001
Publisher Site
http://dx.doi.org/10.1016/j.cyto.2018.12.023DOI Listing
April 2019
2 Reads

Myositis following hidden intraorbital plant foreign body: A case report.

J Fr Ophtalmol 2019 Feb 22;42(2):e69-e71. Epub 2019 Jan 22.

Oculoplastic and Orbital Service, Institut Català de Retina, 67, C. Pau Alcover, 08017 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2018.04.023DOI Listing
February 2019

Dermatomyositis associated with omalizumab therapy for severe asthma: a case report.

Allergy Asthma Clin Immunol 2019 17;15. Epub 2019 Jan 17.

3Department of Medicine, Western University, London, ON Canada.

Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-019-0319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337756PMC
January 2019
1 Read

Fitness genes of group A streptococci in necrotizing fasciitis and myositis.

Authors:
Harry R Hill

J Clin Invest 2019 Feb 22;129(2):516-517. Epub 2019 Jan 22.

Necrotizing fasciitis and myositis caused by group A streptococci (GAS) are among the most fulminating infections, with a mortality rate of 20% to 30%. Although numerous regimens have been utilized in attempts to control these devastating infections, such as combinations of various antimicrobial agents and intravenous immunoglobulin (IVIG) as well as hyperbaric oxygen therapy, none have been the complete answer. Zhu and colleagues have utilized a transposon-directed insertion-site sequencing (TraDIS) protocol to identify 126 genes of M1 and 116 genes of M28 strains of GAS required for myositis, of which 25% encode transporters, which could be used as possible targets for future therapeutic protocols. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI126482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355235PMC
February 2019
3 Reads

Gene fitness landscape of group A streptococcus during necrotizing myositis.

J Clin Invest 2019 Feb 22;129(2):887-901. Epub 2019 Jan 22.

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Necrotizing fasciitis and myositis are devastating infections characterized by high mortality. Group A streptococcus (GAS) is a common cause of these infections, but the molecular pathogenesis is poorly understood. We report a genome-wide analysis using serotype M1 and M28 strains that identified GAS genes contributing to necrotizing myositis in nonhuman primates (NHP), a clinically relevant model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI124994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355216PMC
February 2019
2 Reads
13.215 Impact Factor

West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa.

Emerg Infect Dis 2019 Feb;25(2):367-369

West Nile virus (WNV) is an arthropod-transmitted flavivirus that causes West Nile fever and may infrequently cause neuroinvasive disease in humans. We present 2 cases of confirmed WNV infection, 1 of severe encephalitis and 1 of mild febrile illness, in a couple returning to the United Kingdom from South Africa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2502.172101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346434PMC
February 2019
1 Read

Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito.

Indian J Med Res 2018 Oct;148(4):373-384

Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Human parvovirus B19 (B19V) causes myriads of clinical diseases; however, owing to lack of awareness and undetermined clinical impact, it has failed to become a virus pathogen of global concern. Cryptically, B19V causes significant morbidity and mortality. Half of the world population and 60 per cent of Indians are known to be serologically naive and are at risk of acquiring B19V infections. Read More

View Article

Download full-text PDF

Source
http://www.ijmr.org.in/text.asp?2018/148/4/373/250539
Publisher Site
http://dx.doi.org/10.4103/ijmr.IJMR_533_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362725PMC
October 2018
5 Reads

Poststreptococcal Myalgia and Myositis.

Ann Intern Med 2019 Jan 22. Epub 2019 Jan 22.

Amsterdam UMC, Vrije Universiteit Amsterdam, and Amsterdam Infection & Immunity, Amsterdam, the Netherlands (M.K.B., M.L.V., E.J.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/L18-0589DOI Listing
January 2019
2 Reads

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Jan 18. Epub 2019 Jan 18.

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
January 2019
5 Reads

Atypical Cardiac Manifestations of Systemic Myositis.

J Clin Rheumatol 2019 Jan 18. Epub 2019 Jan 18.

Section of Cardiology, Department of Internal Medicine, and Departments of.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000000992DOI Listing
January 2019
1 Read

Imaging in the diagnosis of idiopathic inflammatory myopathies; indications and utility.

Expert Rev Neurother 2019 Feb 7;19(2):173-184. Epub 2019 Feb 7.

b School of Medicine , Notre Dame University Australia , Fremantle , Australia.

Introduction: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of muscle diseases that carry a significant morbidity and mortality risk. The utilization of imaging in the diagnostic pathway of IIM is therefore important to obtain early diagnosis and even monitor patients over time. Areas covered: Magnetic resonance imaging (MRI) has been the main imaging modality used to detect myositis but limitations include cost and accessibility, leading to delays in time to scan, and patient contraindications. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1572507DOI Listing
February 2019
5 Reads
2.834 Impact Factor

Focal myositis and contracture secondary to amiodarone extravasation from a peripheral cannula.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Department of Neurophysiology, Liverpool Hospital, Sydney, New South Wales, Australia.

A 63-year-old man underwent cardioversion of atrial fibrillation with intravenous amiodarone through an antecubital fossa cannula. Mid-infusion, the cannula tissued. He developed immediate pain and swelling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227725DOI Listing
January 2019
3 Reads

Immune checkpoint inhibitors-related rheumatic diseases: what rheumatologist should know?

Curr Rheumatol Rev 2019 Jan 18. Epub 2019 Jan 18.

Istinye University Faculty of Medicine, Liv Hospital, Department of Rheumatology, Istanbul. Turkey.

Immune checkpoint inhibitors are revolutionized drugs for cancer immunotherapy in the last years. The mechanism of action of CPIs including the limitation of the activation of T-cells, and thus enhancing the self-immune response against tumour cells. Checkpoint-inhibitors(CPIs) may dysregulate the immune system which resulting in some toxicities. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169153/article
Publisher Site
http://dx.doi.org/10.2174/1573397115666190119094736DOI Listing
January 2019
24 Reads

Acute Proximal Myopathy in a Young Male-A Case of Infectious Myositis.

Medicina (Kaunas) 2019 Jan 17;55(1). Epub 2019 Jan 17.

University of Pennsylvania, Philadelphia, PA 19104, USA.

: Acute proximal muscle weakness has a broad differential. Infectious myositis is difficult to differentiate clinically from inflammatory myopathy, often causing a delayed diagnosis. Infectious myositis should be thought of as a differential for proximal muscle pain and weakness in the right context. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55010019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359648PMC
January 2019

Bacteria-Responsive Nanoliposomes as Smart Sonotheranostics for Multidrug Resistant Bacterial Infections.

ACS Nano 2019 Jan 18. Epub 2019 Jan 18.

Rapid emergence of multidrug resistant (MDR) "superbugs" poses a severe threat to global health. Notably, undeveloped diagnosis and concomitant treatment failure remain highly challenging. Herein, we report a sonotheranostic strategy to achieve bacteria-specific labeling and visualized sonodynamic therapy (SDT). Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsnano.8b09336
Publisher Site
http://dx.doi.org/10.1021/acsnano.8b09336DOI Listing
January 2019
11 Reads

Comparison between treatment naive juvenile and adult dermatomyositis muscle biopsies: difference of inflammatory cells phenotyping.

Adv Rheumatol 2018 Oct 26;58(1):37. Epub 2018 Oct 26.

Laboratório de Biologia Molecular e Celular, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Different inflammatory cells (i.e., CD4, CD8, CD20 and CD68) are involved in pathogenesis of DM muscle. Read More

View Article

Download full-text PDF

Source
https://advancesinrheumatology.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s42358-018-0037-5DOI Listing
October 2018
3 Reads

Relevance of serum angiogenic cytokines in adult patients with dermatomyositis.

Adv Rheumatol 2018 Jul 31;58(1):17. Epub 2018 Jul 31.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 3° andar, sala 3150 - Cerqueira César, Sao Paulo, CEP: 01246-903, Brazil.

Background: Until now, there are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM). Therefore, the aims of the present study were: (a) to analyze systematically and simultaneously serum levels of angiogenin (ANG), angiopoietin (ANGPT)-1, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-1 and - 2, platelet derived growth factor (PDGF)-AA and -BB in DM; (b) to correlate the serum level of these cytokines with the DM clinical and laboratory features.

Methods: This is a cross sectional study, in which 48 patients with DM aged 18 to 45 years were gender-, age- and ethnicity-matched with 48 healthy individuals (control group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42358-018-0018-8DOI Listing
July 2018
1 Read

Mycophenolate mofetil in patients with refractory systemic autoimmune myopathies: case series.

Adv Rheumatol 2018 Oct 22;58(1):34. Epub 2018 Oct 22.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 3 andar, sala 3150 - Cerqueira César, CEP 01246-903, Sao Paulo, Brazil.

Background: Currently, there are only few studies (mostly case reports or case series) on mycophenolate mofetil (MMF) in patients with systemic autoimmune myopathies (SAM). Therefore, the goal of the present study was to evaluate the safety and efficacy of MMF (monotherapy or coadjuvant drug) in a specific sample of patients with refractory SAM: dermatomyositis, polymyositis, anti-synthetase syndrome or clinically amyopathic dermatomyositis.

Methods: A case series including 20 consecutive adult patients with refractory SAM from 2010 to 2016 was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42358-018-0035-7DOI Listing
October 2018
1 Read

Favorable rituximab response in patients with refractory idiopathic inflammatory myopathies.

Adv Rheumatol 2018 Sep 18;58(1):31. Epub 2018 Sep 18.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Interpretation of rituximab efficacy for refractory idiopathic inflammatory myopathies (IIM) is hampered by the absence of a uniform definition of refractory myositis and clinical response. Therefore, rigorous criteria of refractoriness, together with a homogenous definition of clinical improvement, were used to evaluate rituximab one-year response.

Methods: A retrospective cohort study including 43 IIM (15 antisynthetase syndrome, 16 dermatomyositis, 12 polymyositis) was conducted. Read More

View Article

Download full-text PDF

Source
https://advancesinrheumatology.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s42358-018-0030-zDOI Listing
September 2018
10 Reads

Physical exercise among patients with systemic autoimmune myopathies.

Adv Rheumatol 2018 May 24;58(1). Epub 2018 May 24.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 3° andar, sala 3150 - Cerqueira César, Sao Paulo, 01246-903, Brazil.

Systemic autoimmune myopathies (SAMs) are a heterogeneous group of rare systemic autoimmune diseases that primarily affect skeletal muscles. Patients with SAMs show progressive skeletal muscle weakness and consequent functional disabilities, low health quality, and sedentary lifestyles. In this context, exercise training emerges as a non-pharmacological therapy to improve muscle strength and function as well as the clinical aspects of these diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42358-018-0004-1DOI Listing
May 2018
1 Read

Serum-soluble TRAIL: a potential biomarker for disease activity in myositis patients.

Clin Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

Department of Rheumatology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing, China.

Objectives: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF super-family, which is involved in the regulation of immune response and pathogenesis of autoimmune diseases, including polymyositis (PM) and dermatomyositis (DM). In this study, we examined the level and origin of serum-soluble TRAIL (sTRAIL) in patients with PM and DM and analyzed its association with disease activity and clinical features.

Method: 11 PM patients, 33 DM patients, and 20 healthy controls were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10067-018-04418-9
Publisher Site
http://dx.doi.org/10.1007/s10067-018-04418-9DOI Listing
January 2019
5 Reads

Systemic sclerosis and myositis as a paraneoplastic syndrome secondary to multiple myeloma.

Acta Reumatol Port 2018 Oct-Dec;43(4):316-317

Hospital Conde de Bertiandos - Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal.

We present a case of paraneoplastic systemic sclerosis (SSc) and myositis associated to a multiple myeloma (MM) in a 52-year-old Caucasian man. After MM treatment, skin and muscle changes improved, with no further relapses. Although rare, "scleroderma-like" or myositis lesions may be associated with MM. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis.

Gerontology 2019 Jan 14:1-13. Epub 2019 Jan 14.

Department of Exercise Biochemistry, Korea National Sport University, Seoul, Republic of

Background: Mitochondrial dysfunction is implicated in the pathogenesis of multiple muscular diseases, including sporadic inclusion body myositis (s-IBM), the most common aging-related muscle disease. However, the factors causing mitochondrial dysfunction in s-IBM are unknown.

Objective: We hypothesized that resistance exercise (RE) may alleviate muscle impairment by improving mitochondrial function via reducing amyloid-beta (Aβ) accumulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494723DOI Listing
January 2019
1 Read

Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy.

Hum Pathol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Pathology, University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.

Myositis ossificans (MO) is an uncommon myofibroblastic proliferation that may closely mimic sarcoma. A 33-year old woman presented with a 2cm breast mass. A core needle biopsy showed highly cellular spindle cell proliferations with atypia and high proliferation activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2018.12.008DOI Listing
January 2019
1 Read

Review: Myositis-specific autoantibodies, a cornerstone in immune-mediated necrotizing myopathy.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Internal Medicine and Clinical Immunology, Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France; Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, Centre de Recherche en Myologie, UMRS974, Paris, France. Electronic address:

Over the past few years, myositis-specific autoantibodies played an increasing role in the inflammatory idiopathic myositis definition. They became the critical immunological marker for immune-mediated necrotizing myopathy diagnosis (IMNM) since the paradigm switch from histological to serological criteria. This review is focused on the key role of the anti-signal recognition particle (anti-SRP) and the anti-3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase (anti-HMGCR) antibodies in immune-mediated necrotizing myopathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193000
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.09.008DOI Listing
January 2019
13 Reads

Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Microbiology and Immunology, Experimental Laboratory Immunology, KU Leuven, Leuven, Belgium; Laboratory of Medicine, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by immune-mediated muscular lesions that may be associated with extra-muscular manifestations involving skin, lungs, heart or joints. Four main groups of IIM can be distinguished: dermatomyositis (DM), overlap myositis including mainly anti-synthetase syndrome (ASS), immune mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM). Myositis-specific autoantibodies (MSA) are increasingly recognized as valuable tools for diagnosis, classification and prognosis of IIM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.004DOI Listing
January 2019
2 Reads
7.933 Impact Factor

Clinical spectrum of neuromuscular complications after immune checkpoint inhibition.

Neuromuscul Disord 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology, University of Pittsburgh Medical Center, 3471 Fifth Ave #810, Pittsburgh, PA 15213, United States. Electronic address:

Cancer immunotherapy has transformed the field of oncology and enabled more effective management of previously refractory neoplasms by activation of the immune response. Upregulation of the immune response may also trigger autoimmune adverse events, including neuromuscular complications. We performed a systematic review of autoimmune neuromuscular complications following immune checkpoint blockade. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nmd.2018.11.012DOI Listing
December 2018
1 Read