25,418 results match your criteria Infectious Myositis

Epidemiology, survival and clinical characteristics of inclusion body myositis.

Ann Neurol 2022 May 20. Epub 2022 May 20.

Department of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Objective: We performed a population-based study on inclusion body myositis with the primary aims to define the prevalence, survival rate and incidence and to investigate the symptom profiles associated with disease duration and sex over a 33-year period.

Methods: Patients diagnosed between 1985 and 2017 in Region Västra Götaland, Sweden were identified according to the European Neuromuscular Centre diagnostic criteria from 2011.

Results: We identified 128 patients, 89 men and 39 women with the strict clinico-pathologically definition of inclusion body myositis. Read More

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Lack of muscle stem cell proliferation and myocellular hypertrophy in sIBM patients following blood-flow restricted resistance training.

Neuromuscul Disord 2022 Apr 26. Epub 2022 Apr 26.

Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Rheumatology, Odense University Hospital, Odense, Denmark.

Sporadic inclusion body myositis (sIBM) is characterised by skeletal muscle inflammation, progressive muscle loss and weakness, which is largely refractory to immunosuppressive treatment. Low-load blood-flow restricted (BFR) training has been shown to evoke gains in myofibre cross sectional area (mCSA) in healthy adults. This could partially be due to the activation and integration of muscle satellite cells (SC) resulting in myonuclei addition. Read More

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A rare case of docetaxel-induced myositis in a patient with a lung adenocarcinoma.

Thorac Cancer 2022 May 20. Epub 2022 May 20.

Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.

Docetaxel is a cytotoxic taxane frequently used to treat patients with various cancers, including non-small cell lung cancer (NSCLC). Docetaxel is known to cause acute myalgias, arthralgias, and neuropathy, but there have been few published case reports of myositis. Here, we describe a rare case of docetaxel-induced myositis diagnosed based on laboratory data, thigh magnetic resonance imaging (MRI), and electromyography (EEG). Read More

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Diagnostic impact of F-FDG PET/CT imaging on the detection of immune-related adverse events in patients treated with immunotherapy.

Clin Transl Oncol 2022 May 20. Epub 2022 May 20.

Department of Nuclear Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Introduction: Immunotherapy is an effective treatment method for cancer cells with humoral and cellular immune mechanisms of action but triggers an inflammatory response and disrupts standard protective immune tolerance. Early detection of immune-related adverse events (irAEs) on PET/CT is crucial for patient management and subsequent therapy decisions. In this study, we aimed to evaluate the impact of F-FDG PET/CT on detecting of irAEs in patients receiving immunotherapy. Read More

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Resistin Expression Is Associated With Interstitial Lung Disease in Dermatomyositis.

Front Med (Lausanne) 2022 3;9:903887. Epub 2022 May 3.

Department of Rheumatology, Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, China.

Objective: In the current study, we aimed to assess resistin mRNA levels in the peripheral blood mononuclear cells (PBMCs) of dermatomyositis patients with interstitial lung disease (DM-ILD) and their correlation with disease activity.

Methods: We detected resistin mRNA levels in the PBMCs of 37 DM-ILD, 8 DM patients without ILD, and 19 healthy control (HC) subjects by performing quantitative reverse transcription real-time polymerase chain reaction analysis. Associations between resistin expression levels and major clinical manifestations, laboratory examinations, and disease activity were also analyzed. Read More

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Clinical Characteristics of Idiopathic Orbital Inflammation Syndrome in Relation to Intraocular Pressure.

Clin Ophthalmol 2022 11;16:1467-1473. Epub 2022 May 11.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Purpose: To investigate the clinical characteristics of idiopathic orbital inflammation and changes in intraocular pressure (IOP) before and after its treatment.

Patients And Methods: We retrospectively studied 20 eyes from the medical records of 19 patients who were diagnosed with idiopathic orbital inflammation between April 1, 2004, and April 30, 2019, at Toyama University Hospital. The inflammation site (type of disease), treatment provided, IOP before and after treatment, and the symptoms (proptosis, decreased ocular movements or diplopia, periorbital edema, and ocular pain) were analyzed. Read More

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Streptococcus sanguinis Endocarditis of Bicuspid Aortic Valve Presenting as Septic Arthritis of Lumbar Facet Joint.

Cureus 2022 Apr 16;14(4):e24189. Epub 2022 Apr 16.

Internal Medicine, University of Illinois College of Medicine, Peoria, USA.

Septic arthritis of the facet joint (SAFJ) is an uncommon etiology of low back pain that usually affects the elderly population and immunocompromised patients but is rare in immunocompetent and young patients. When such a clinical presentation occurs, it is imperative to diagnose the source of the infection. We report a case of septic arthritis of the left third and fourth lumbar vertebrae facet joint due to in a young immunocompetent adult, and the source of infection was found to be subacute infective endocarditis of a bicuspid aortic valve which was undiagnosed till now. Read More

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Not a Statin-Induced Myopathy: Metastatic Pancreatic Adenocarcinoma Presenting As Paraneoplastic Myositis.

Cureus 2022 May 15;14(5):e25016. Epub 2022 May 15.

Internal Medicine, Saint Francis Hospital, Hartford, USA.

Polymyositis is an inflammatory disease that causes bilateral proximal muscle weakness; unlike dermatomyositis, it is not usually associated with malignancy. However, there are a handful of case reports documenting polymyositis in patients with lymphoma, breast, lung, and bladder cancer. Here we report a case of metastatic pancreatic adenocarcinoma disguised by presenting as polymyositis. Read More

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[Treatment of Dermatomyositis and Immune-Mediated Necrotizing Myopathy with Poor Muscle Recovery with Steroids and IVIg: Therapeutic Strategies for Refractory Inflammatory Myositis].

Brain Nerve 2022 May;74(5):545-552

Department of Neurology, JA Toride Medical Center.

The majority of inflammatory myositis cases can be cured by immunomodulatory therapies. We recently observed that the phenotype and response to therapies differed according to myositis-specific autoantibodies; therefore, it is essential to select a suitable therapy after thoroughly evaluating the autoantibody, clinical severity, and complications. In some cases, the symptoms can be controlled by steroid monotherapy, but some cases exhibit steroid resistance and require other therapies. Read More

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Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome.

Ther Adv Chronic Dis 2022 13;13:20406223221098128. Epub 2022 May 13.

Department of Rheumatology, Key Laboratory of Myositis, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, 100029 Beijing, China.

Background: Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis (DM) has low survival rate, whereas macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases. Their coexistence is very rare. This study aimed to describe the prevalence, clinical characteristics, and outcomes of anti-MDA5 antibodies-positive DM patients complicated with MAS. Read More

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Therapy-resistant dermatomyositis with extensive 'lumbar belt' calcinosis.

BMJ Case Rep 2022 May 18;15(5). Epub 2022 May 18.

Systemic Autoimmune and Rares Diseases Unit. Internal Medicine Department, Hospital Virgen del Rocio, Seville, Spain.

Calcinosis cutis (CC) is the umbrella term for calcium salt deposition on skin and subcutaneous tissue. We present a unique case of CC associated with anti-Mi2-positive dermatomyositis, having a distinctive distribution of subcutaneous calcifications appearing as a 'lumbar belt'. Treatment of CC remains challenging for clinicians due to a lack of high-quality evidence. Read More

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Long-term Outcome in 7 Patients With Idiopathic Orbital Myositis.

Toshihiko Matsuo

Jpn Clin Med 2019 12;10:1179670719866525. Epub 2019 Aug 12.

Department of Ophthalmology, Okayama University Hospital and Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan.

Purpose: Idiopathic orbital myositis, a rare disease of unknown cause, presents a diagnostic puzzle because the diagnosis is based on the exclusion of other diseases. This study aims at elucidating its long-term outcome to answer a clinical question whether idiopathic orbital myositis would be a distinct clinical entity.

Methods: Retrospective review was made on 7 consecutive patients (6 men and 1 woman) with the age at the initial visit ranging from 33 to 69 years (mean, 45. Read More

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Ipilimumab-related orbitopathy: a case report.

Orbit 2022 May 17:1-5. Epub 2022 May 17.

Moran Eye Center, University of Utah John A., Salt Lake City, Utah, USA.

Ipilimumab, an immune checkpoint inhibitor used in the treatment of metastatic melanoma, can cause immune-related adverse events including rare ocular-related inflammation. This is a case of a 54-year-old man with metastatic melanoma and bilateral orbital inflammation associated with ipilimumab that occurred after drug rechallenge 6 years after initial orbital inflammation with ipilimumab use. Imaging revealed tendon-involving myositis. Read More

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Polymyositis as a paraneoplastic syndrome of a patient with primary pulmonary lymphoepithelioma-like carcinoma: a case report and literature review.

J Cardiothorac Surg 2022 May 17;17(1):120. Epub 2022 May 17.

Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, Shizhong District, No. 1866, West Section of Hanan Avenue, Neijiang, 641000, Sichuan, China.

Background: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer, which mostly occurred in non-smoking Asian populations. The prognosis of this tumor is better than other lung cancers. Polymyositis, a kind of idiopathic inflammatory myopathies, may negatively affect the prognosis of patients with lung cancer as a paraneoplastic syndrome (PNPS). Read More

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Pain profile and opioid medication use in patients with idiopathic inflammatory myopathies.

Rheumatology (Oxford) 2022 May 17. Epub 2022 May 17.

Myositis Support and Understanding, Lincoln, DE.

Objectives: Pain is commonly reported in people living with myositis. This study assesses the presence of pain in the subtypes of myositis as well frequency of opioid and non-opioid pain medication use.

Methods: A survey was developed and distributed by Myositis Support and Understanding, a patient-led advocacy organization, to members of its group. Read More

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Health-related quality of life in patients with mixed connective tissue disease: a comparison with matched systemic sclerosis patients.

Clin Exp Rheumatol 2022 05 2;40 Suppl 134(5):66-70. Epub 2022 May 2.

Department of Rheumatology, Leiden University Medical Center, The Netherlands.

Objectives: Health-Related Quality of Life (HRQoL) in adult patients with mixed connective tissue disease (MCTD) has not been described so far. Therefore, we performed an explorative study to evaluate HRQoL in MCTD patients.

Methods: MCTD patients fulfilling the Kahn criteria and participating in the prospective follow-up cohort for MCTD of the Leiden University Medical Center were included; and matched to systemic sclerosis (SSc) patients based on age, sex and disease duration. Read More

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Embolie pulmonaire septique et pyomyosite à .

CMAJ 2022 May;194(19):E689-E690

Département de médecine interne, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Inde

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Evaluation of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies Through Semiquantitative and Quantitative Analysis of Lung Computed Tomography.

J Thorac Imaging 2022 May 9. Epub 2022 May 9.

Department of Diagnostic Imaging, 2nd Radiology Unit, Pisa University Hospital, Pisa.

Purpose: To perform a semiquantitative and quantitative analysis of interstitial lung disease (ILD), through computed tomography (CT), in different serological subgroups of idiopathic inflammatory myopathies (IIM) patients, to find radiologic and clinical differences of disease related to serology.

Materials And Methods: This was a prospective study, which included 98 IIM patients, divided into serological subgroups: anti-aminoacyl-transfer-RNA-synthetases (anti-ARS) positive and myositis-specific autoantibodies (MSA) negative.For each baseline CT the total semiquantitative score of Warrick (WS) and the automated software (Computer-Aided Lung Informatics for Pathology Evaluation and Rating) quantitative scores interstitial lung disease % (ILD%) and vascular-related structure % (VRS%) were calculated. Read More

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Fibro Dysplasia Ossificans Progressiva.

Emrah Dogan

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):394

Muğla Sıtkı Koçman University, Turkey.

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The first case of proliferative fasciitis of tongue coexistent with squamous cell carcinoma: Case report of a rare lesion.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):129. Epub 2022 Mar 31.

Department of Pathology, Dr. Ulhas Patil Medical College and Hospital, Jalgaon (Khurd), Maharashtra, India.

Proliferative fasciitis (PF) is a rare pseudosarcomatous myofibroblastic benign tumor, a subcutaneous counterpart of proliferative myositis. Usually seen in upper extremities, no case has yet been documented in tongue or any other subsites in oral cavity. The present case becomes the first to be reported at this site as well as the first case of synchronous coexistent PF with squamous cell carcinoma (SCC) of tongue. Read More

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Treatment of MDA5-positive dermatomyositis complicated by gangrenous cholecystitis with tofacitinib.

Eur J Med Res 2022 May 15;27(1):68. Epub 2022 May 15.

Suining Central Hospital, 127 Desheng West Road, Chuanshan, Suining, 629000, Sichuan, China.

Background: Dermatomyositis is a rare idiopathic inflammatory disease with diverse presentations that can have varying degrees of cutaneous and systemic involvement. This phenotypic heterogeneity makes DM a therapeutic challenge. Some therapeutic drugs, such as hormones and immunosuppressants, have poor therapeutic effects. Read More

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Myositis-associated Interstitial Lung Disease: Clinical Characteristics and Factors Related to Pulmonary Function Improvement: A Latin-American Multicenter Cohort Study.

Reumatol Clin (Engl Ed) 2022 May;18(5):293-298

Hospital Juan A. Fernández, Buenos Aires, Argentina.

Background And Objectives: ILD patients can be positive to highly specific autoantibodies of connective tissue diseases (CTD). Among them stand out myositis-specific and associated autoantibodies (MSA/MAA). There is limited knowledge about treatment response and prognosis of ILD patients positive to MSA/MAA (MSA/MAA-ILD). Read More

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Current approach to diagnosis of inflammatory myopathies: Clinical features and myositis antibody profiles.

Indian J Pathol Microbiol 2022 May;65(Supplement):S252-S258

Department of Clinical Immunology and Rheumatology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Diagnosis of inflammatory myositis has been made easier with the availability of commercial assays for myositis-specific and myositis-associated antibodies. Clinico-serological association studies have permitted a better definition of clinical subsets. Myositis-specific auto-antibodies are highly specific and non-overlapping, whereas myositis-associated antibodies are those seen also in other connective tissue disorders such as systemic lupus erythematosus, primary Sjogren's syndrome, and idiopathic pulmonary auto-immune fibrosis. Read More

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Evolving classification and role of muscle biopsy in diagnosis of inflammatory myopathies.

Indian J Pathol Microbiol 2022 May;65(Supplement):S241-S251

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Idiopathic inflammatory myopathy (IIM) is a broad term that includes dermatomyositis, polymyositis, overlap myositis, sporadic inclusion body myositis, and immune-mediated necrotizing myopathy. The understanding of the pathogenesis of IIM is ever-evolving with regular updates in the classification schema. With the recognition of autoantibodies and their detection, the diagnostic algorithms are changing in favor of non-invasive diagnoses. Read More

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Basic requirements to establish a neuromuscular laboratory.

Indian J Pathol Microbiol 2022 May;65(Supplement):S233-S240

Department of Neuropathology, NIMHANS, Bangalore, Karnataka, India.

Histopathological analysis of muscle biopsy is a prerequisite in the evaluation of neuromuscular disorders, particularly inflammatory myopathies, metabolic myopathies, congenital myopathies, muscular dystrophies and differentiating myopathies and neurogenic disorders with overlapping clinically features. It not only provides useful information that helps in the diagnosis but also treatment and management. Fundamental skills and basic knowledge regarding handling, processing and analyzing a muscle biopsy are required in any specialized or a general pathology lab supporting neuromuscular clinical services. Read More

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Post Covıd-19 Vaccınatıon Inflammatory Syndrome: A Case Report.

Mod Rheumatol Case Rep 2022 May 12. Epub 2022 May 12.

Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul-Cerrahpasa, Istanbul, Turkey.

A previously healthy 24-year-old male patient was referred to our clinic with bilateral lower extremity pain and dark urine, which developed two weeks after receiving the second dose of BNT162b2 vaccine against SARS-CoV-2. Laboratory tests indicated rhabdomyolysis. Lower extremity magnetic resonance imaging was compatible with myositis. Read More

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Patterns of body composition and alteration after treatment in patients with newly diagnosed idiopathic inflammatory myopathies.

Rheumatology (Oxford) 2022 May 12. Epub 2022 May 12.

Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, 400016, China.

Objectives: To define the pattern of body composition and alteration after treatment of patients with newly diagnosed idiopathic inflammatory myopathies (IIM) using dual-energy X-ray absorptiometry (DXA).

Methods: DXA was used to obtain regional and whole-body measurements of fat mass (FM) and lean tissue mass (LTM) in 50 patients with newly diagnosed IIM and matched controls. The DXA indices of FM and LTM were calculated. Read More

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Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases.

Arthritis Res Ther 2022 May 12;24(1):107. Epub 2022 May 12.

Department of Internal Medicine III, Jena University Hospital - Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany.

Background: Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity and mortality. That is why ILD screening at a very early stage, at the onset of IRD, is essential. The objective of the present study was to evaluate the diagnostic value and utility of a stepwise approach as a potential ILD screening tool in patients with newly diagnosed IRD. Read More

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Coexisting sporadic late onset nemaline myopathy and AL amyloid myopathy - incidental or related?

Neuromuscul Disord 2022 Mar 26. Epub 2022 Mar 26.

Department of Neurology, Oregon Health & Science University, Portland, OR, USA. Electronic address:

Sporadic late onset nemaline myopathy (SLONM) and amyloid myopathy are frequently unrecognized acquired and treatable myopathies, which classically present with rapidly progressive and severe proximal muscle weakness. We report a case of SLONM and amyloid myopathy associated with IgM lambda monoclonal gammopathy in a 77-year-old Caucasian man. Creatine kinase (CK) was mildly elevated. Read More

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