9,924 results match your criteria Infectious Endocarditis


Bloodstream infection in hospital therapeutic patients.

Klin Lab Diagn 2022 Jun;67(6):355-361

G.N. Gabrichevskii Moscow research institute for epidemiology and microbiology for Rospotrebnadzor.

Bloodstream infection (BI) is the cause of high mortality. Hospital bloodstream infection (HBI) complicates hemodialysis, pneumonia, oncohematological diseases. Positive hemoculture obtaining depends on the volume of blood inoculation, the number of blood samples, the incubation time. Read More

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Bartonella quintana Infection in People Experiencing Homelessness in the Denver Metropolitan Area.

J Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, U.S.A.

Background: Bartonella quintana is an important cause of infection amongst people experiencing homelessness that is underdiagnosed due to its non-specific clinical manifestations. We reviewed cases identified in the Denver Metropolitan Area from 2016-2021.

Methods: The electronic medical records from two large academic medical centers in Colorado were reviewed for demographic, clinical, and laboratory features of patients with B. Read More

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Outpatient parenteral antimicrobial therapy (OPAT) service is associated with inpatient-bed cost savings.

Br J Cardiol 2021 1;28(3):38. Epub 2021 Sep 1.

Consultant Cardiologist Department of Cardiology, Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent, ST4 6QG.

In a cardiology department, there are some patients that require long-term antibiotics, such as those with infective endocarditis or infected prosthetic devices. We describe our experience with intravenous antibiotic therapy for patients with cardiology diagnoses who require a period of antibiotics in our outpatient service during the period of the COVID-19 pandemic. A total of 15 patients were selected to have outpatient antibiotic therapy (age range 36 to 97 years, 60% male). Read More

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September 2021

Non-bacterial Thrombotic Endocarditis as a Rare Manifestation of Early Stage Gastric Cancer.

Cureus 2022 May 22;14(5):e25213. Epub 2022 May 22.

Internal Medicine Department, Curry Cabral Hospital, Central Lisbon University Hospital Centre, Lisbon, PRT.

Endocarditis is an inflammation of the endocardium and is characterized by the presence of vegetation, which may occur in the context of infectious or non-infectious diseases. Despite the higher rate of infective endocarditis diagnosis, it may also surge in other non-infectious conditions such as cancer or chronic inflammatory syndromes. Cancer defines a hypercoagulable state, and cancer-associated thrombophilia can have a diverse clinical presentation, most commonly venous thromboembolism and rarely non-bacterial thrombotic endocarditis (NBTE). Read More

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Sex Differences in Characteristics of Patients with Infective Endocarditis: A Multicenter Study.

J Clin Med 2022 Jun 18;11(12). Epub 2022 Jun 18.

School of Medicine, West Virginia University, Morgantown, WV 26506, USA.

Infectious diseases like infective endocarditis (IE) may manifest or progress differently between sexes. This study sought to identify the differences in demographic and clinical characteristics among male and female patients with IE. Data were obtained from a newly developed registry comprising all adult patients with first IE admission at the four major tertiary cardiovascular centers in West Virginia, USA during 2014-2018. Read More

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High Incidence of Acute Kidney Injury in Patients Treated with High-Dose Amoxicillin and Cloxacillin Combination Therapy.

Antibiotics (Basel) 2022 Jun 4;11(6). Epub 2022 Jun 4.

Department of Nephrology, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.

High-dose amoxicillin and cloxacillin combination therapy is recommended for the empiric treatment of selected patients with infective endocarditis despite a low level of evidence. The main objective of this study was to evaluate the renal tolerance of high-dose intravenous amoxicillin and cloxacillin combination. We studied 27 patients treated with amoxicillin and cloxacillin (≥100 mg/kg daily) for at least 48 h. Read More

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A Proposal for Addiction and Infectious Diseases Specialist Collaboration to Improve Care for Patients With Opioid Use Disorder and Injection Drug Use Associated Infective Endocarditis.[.

J Addict Med 2021 Oct 27. Epub 2021 Oct 27.

Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE.

Patients with injection drug use-associated infective endocarditis and opioid use disorder often receive treatment for the infection that fails to address its underlying cause. People who inject drugs (PWID) and develop serious infections also face disparities in antibiotic management, particularly with regards to use of outpatient parenteral antimicrobial therapy (OPAT). We highlight literature on OPAT in PWID challenging the notion that PWID cannot be managed with OPAT. Read More

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October 2021

Between a Rock and a Hard Place: Percutaneous Aspiration and Debulking for Tricuspid Valve Endocarditis.

Cureus 2022 May 20;14(5):e25166. Epub 2022 May 20.

Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, USA.

Right-sided infective endocarditis (IE) constitutes about 10% of total IE cases. Of these, tricuspid endocarditis comprises about 90% of all right-sided IE cases with intravenous drug use (IVDU) as its strongest risk factor. In patients with larger vegetations (>20 mm) or with persistent bacteremia, surgical intervention is often the standard of care. Read More

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Evaluation of inter-observer variability regarding aortic and mitral valve findings on transesophageal echocardiograms ordered for suspected endocarditis.

Echocardiography 2022 Jun 22. Epub 2022 Jun 22.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Background: Transesophageal echocardiography (TEE) is the gold standard for the detection of valvular vegetations (VV). Differentiating small VV from degenerative changes is challenging and prone to inter-observer variability. We evaluated inter-observer agreement regarding aortic (AV) and mitral valve (MV) findings on TEEs ordered for suspected infective endocarditis (IE). Read More

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Infective endocarditis in patients with rheumatic heart disease: a single-centre retrospective comparative study.

N Z Med J 2022 Feb 25;135(1550):62-73. Epub 2022 Feb 25.

Cardiologist, Green Lane Cardiovascular Service, Auckland City Hospital.

Aims: We reviewed the baseline characteristics and outcomes of patients with infective endocarditis (IE) and compared those with and without rheumatic heart disease (RHD).

Methods: We retrospectively reviewed patients ≥15 years with IE treated at Auckland City Hospital between January 2016 and December 2018 and excluded device-related IE and complex congenital heart disease. RHD status was based on echocardiographic features or previous history of rheumatic fever with valvular disease. Read More

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February 2022

Erythrodermic Psoriasis and Staph-Infective Endocarditis-A Conundrum in Succession.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221105243

Department of Internal Medicine, Kern Medical, Bakersfield, CA, USA.

Erythrodermic psoriasis is a rare subtype of psoriasis vulgaris that presents with diffuse erythema and desquamation over greater than 75% of the body's surface area. We present a case of a 57-year-old male who was admitted with a diffuse, erythematous scaly rash covering his entire body, with associated subjective fevers. Skin biopsy revealed erythrodermic psoriasis, and blood cultures were positive for methicillin-sensitive . Read More

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Brain abscess due to Aggregatibacter aphrophilus in association with atrial septal defect:Case report and literature review.

Clin Neurol Neurosurg 2022 Jun 11;219:107337. Epub 2022 Jun 11.

National Center for Infectious Diseases research, The Third People's Hospital of Shenzhen, Shenzhen, China. Electronic address:

Background: Aggregatibacter aphrophilus(A. aphrophilus)is one of the organisms of the HACEK group. Previously reported cases of brain abscesses caused by A. Read More

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Catastrophic Perforation in Streptococcus Pneumoniae Aortitis: Complications of Infective Endocarditis in the Current Antimicrobial Era.

J Community Hosp Intern Med Perspect 2022 31;12(1):48-53. Epub 2022 Jan 31.

Department of Internal Medicine, SSM St. Mary's Hospital - St. Louis, St. Louis, MO 63117, USA.

Infectious aortitis is an uncommon but life-threatening cause of aortitis. Given the lack of specific symptoms, establishing the diagnosis is often a challenge. When it is associated with an endovascular infection, such as infective endocarditis, blood cultures may be diagnostic although often limited by low positive predictive value. Read More

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January 2022

, a novel pathogen causing destructive infective endocarditis requiring mitral annular reconstruction.

JTCVS Tech 2022 Jun 15;13:70-73. Epub 2022 Apr 15.

Department of Cardiothoracic Surgery, Townsville University Hospital, Townsville, Queensland, Australia.

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A Case Series of Eustachian Valve Endocarditis: An Under-Diagnosed and Rare Entity.

Am J Case Rep 2022 Jun 17;23:e936279. Epub 2022 Jun 17.

Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.

BACKGROUND The eustachian valve is rarely involved in bacterial endocarditis. Patients who present with bacteremia and evidence of organic septic emboli should raise the suspicion of endocarditis as a possible differential diagnosis. This case series describes 2 unique cases of eustachian valve endocarditis (EVE) in patients who had a history of intravenous drug use; although 63% of EVE is caused by Staphylococcus aureus, the causative agent in our first case was methicillin-resistant Staphylococcus epidermidis (MRSE), which is only the third reported case of EVE caused by Staphylococcus epidermidis. Read More

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INFECTIVE ENDOCARDITIS IN PREGNANCY: A CONTEMPORARY COHORT.

Am J Perinatol 2022 Jun 16. Epub 2022 Jun 16.

Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, United States.

Objective Pregnancy-related infective endocarditis (IE) caries a high risk of morbidity and mortality. With increasing intravenous drug abuse (IVDA) amid the opioid epidemic, the risk factor profile may be shifting. In this case series, we aimed to describe risk factors and outcomes for peripartum IE in a contemporary cohort. Read More

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Not Your Usual Case of Culture-Negative Endocarditis: A Case Report of Bartonella Endocarditis.

Cureus 2022 May 12;14(5):e24947. Epub 2022 May 12.

Infectious Disease, Sarasota Memorial Hospital, Florida State University College of Medicine, Sarasota, USA.

Advancements in transcatheter interventions have revolutionized the treatment of adult congenital heart disease. We present a case of a 32-year-old male with a history of tetralogy of Fallot with pulmonary atresia diagnosed with spp. culture-negative infective endocarditis (IE) of his Melody valve, necessitating Melody valve replacement. Read More

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Alternative Nuclear Imaging Tools for Infection Imaging.

Curr Cardiol Rep 2022 Jun 13. Epub 2022 Jun 13.

Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, Via Roma 57, 56126, Pisa, Italy.

Purpose Of Review: Cardiovascular infections are serious disease associated with high morbidity and mortality. Their diagnosis is challenging, requiring a proper management for a prompt recognition of the clinical manifestations, and a multidisciplinary approach involving cardiologists, cardiothoracic surgeons, infectious diseases specialist, imagers, and microbiologists. Imaging plays a central role in the diagnostic workout, including molecular imaging techniques. Read More

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Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry.

Eur Heart J 2022 Jun 8. Epub 2022 Jun 8.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Aim: Fatality of infective endocarditis (IE) is high worldwide, and its diagnosis remains a challenge. The objective of the present study was to compare the clinical characteristics and outcomes of patients with culture-positive (CPIE) vs. culture-negative IE (CNIE). Read More

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Connections between Exoproteome Heterogeneity and Virulence in the Oral Pathogen Aggregatibacter actinomycetemcomitans.

mSystems 2022 Jun 13:e0025422. Epub 2022 Jun 13.

University of Groningen, University Medical Center Groningengrid.4494.d, Department of Medical Microbiology, Groningen, the Netherlands.

Aggregatibacter actinomycetemcomitans is a Gram-negative bacterial pathogen associated with severe periodontitis and nonoral diseases. Clinical isolates of A. actinomycetemcomitans display a rough (R) colony phenotype with strong adherent properties. Read More

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Dealing with the epidemic of endocarditis in people who inject drugs.

Can J Cardiol 2022 Jun 9. Epub 2022 Jun 9.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario; Division of Cardiac Surgery, University of Toronto, Toronto, Ontario; Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario. Electronic address:

North America is facing an opioid epidemic and growing illicit drug supply, contributing to growing numbers of injection drug use-related infective endocarditis (IDU-IE). Patients with IDU-IE have high early and late mortality. Patients with IDU-IE more commonly present with right-sided IE compared to those with non-IDU-IE and a majority are a result of S. Read More

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Molecular Analysis with16s rRNA PCR/Sanger Sequencing and Molecular Antibiogram performed on DNA extracted from valve improve diagnosis and targeted therapy of Infective Endocarditis: a prospective study.

Clin Infect Dis 2022 Jun 10. Epub 2022 Jun 10.

Research department, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy.

Background: Molecular analysis (MA) on heart valve (HV) improves the microbiologic diagnosis of infectious endocarditis (IE). The main drawback of MA is the lack of antimicrobial susceptibility information.

Methods: We conducted a prospective cohort observational study of consecutive adult patients from April 2012 to May 2021 who underwent valve surgery at our hospital. Read More

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[A case of acute renal failure revealing brucellian endocarditis and neurological complications in Batna (Algeria)].

Med Trop Sante Int 2022 03 30;2(1). Epub 2022 Mar 30.

Faculté de médecine, Université Batna 2, Batna, Algérie.

Introduction: Brucellosis is a major zoonosis affecting livestock and transmitted to humans; it is widespread worldwide with 500,000 new cases per year according to the World Health Organization. It has become rare in countries that have established an eradication policy of the disease in animals and pasteurization of milk, but remains endemo-epidemic in Algeria, where it constitutes a public health problem (incidence of 24.41 per 100,000 inhabitants in 2017). Read More

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Surgical techniques for infectious endocarditis of the mitral valve with hypertrophic cardiomyopathy in Costello syndrome.

J Cardiol Cases 2022 Jun 14;25(6):367-369. Epub 2022 Jan 14.

Department of Cardiac Surgery, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.

Costello syndrome is a rare congenital disease caused by activating germline mutations, and it is often associated with cardiac abnormalities. A 17-year-old male with a history of Costello syndrome presented with persistent fever. Vegetation attached to anterior mitral leaflet was detected, and antibiotic therapy was administered as treatment for infectious endocarditis. Read More

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Microbial Cell-Free DNA Identifies the Causative Pathogen in Infective Endocarditis and Remains Detectable Longer Than Conventional Blood Culture in Patients with Prior Antibiotic Therapy.

Clin Infect Dis 2022 Jun 10. Epub 2022 Jun 10.

Karius, Inc., Redwood City, California, USA.

Background: The diagnosis of infective endocarditis (IE) can be difficult, particularly if blood cultures fail to yield a pathogen. This study evaluates the potential utility of microbial cell-free DNA (mcfDNA) as a tool to identify the microbial etiology of IE.

Methods: Blood samples from patients with suspected IE were serially collected. Read More

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May Be Associated with the Virulence of by Increasing the Expression of and .

Infect Drug Resist 2022 2;15:2853-2864. Epub 2022 Jun 2.

Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Introduction: is an opportunistic pathogen that can cause life-threatening bloodstream infections such as sepsis and endocarditis. In recent years, the emergence and increase of methicillin-resistant and multidrug-resistant has posed a great challenge to the antibiotic treatment of infectious diseases. Anti-virulence strategies targeting virulence factors are an effective new therapy for the treatment of infections. Read More

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Nosocomial Valve Endocarditis after Crimean-Congo Hemorrhagic Fever.

Rev Soc Bras Med Trop 2022 6;55:e0691. Epub 2022 Jun 6.

Atatürk University, Faculty of Medicine, Department of Cardiovascular Surgery, Erzurum, Turkey.

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Apyretic pulmonary oedema revealing endocarditis: Case report and review of literature.

IDCases 2022 21;29:e01506. Epub 2022 May 21.

Laboratoire Bactériologie Hygiène, CHU Lille, Univ Lille, 59037 Lille, France.

is a member of the HACEK group of bacteria, responsible for infective endocarditis, mainly in patients with damaged or prosthetic valves. The low virulence of this organism can explain the insidious presentation and subacute or chronic progression of infective endocarditis. Here, a 41-year-old man with a past history of surgery for a Waldhausen type aortic coarctation was hospitalised with dyspnea and chest pains revealing an acute pulmonary oedema, without fever. Read More

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bacteremia and its implications: A case report.

IDCases 2022 20;29:e01516. Epub 2022 May 20.

Department of Infectious Disease, University Medical Center, 1800 W Charleston Blvd, Las Vegas, NV 89102, United States.

Background: The species is a gram positive, anaerobic, rod-shaped microbe that is known to produce many toxins. Most infections by the species involve , , and . However, other types of species are also clinically relevant, such as and . Read More

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Process mapping strategies to prevent subcutaneous implantable cardioverter-defibrillator infections.

J Cardiovasc Electrophysiol 2022 Jun 3. Epub 2022 Jun 3.

Department of Medicine, Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Background: Infection remains a major complication of cardiac implantable electronic devices and can lead to significant morbidity and mortality. Implantable devices that avoid transvenous leads, such as the subcutaneous implantable cardioverter-defibrillator (S-ICD), can reduce the risk of serious infection-related complications, such as bloodstream infection and infective endocarditis. While the 2017 AHA/ACC/HRS guidelines include recommendations for S-ICD use for patients at high risk of infection, currently, there are no clinical trial data that address best practices for the prevention of S-ICD infections. Read More

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