8,881 results match your criteria Infectious Endocarditis


Infectious stentitis after treatment of coarctation of the aorta: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Background: Aortitis is a rare condition that can be caused by inflammatory or infectious aetiologies. The clinical presentation of aortitis includes a heterogeneous range of symptoms and clinical signs.

Case Summary: We present a 53-year-old man whose medical history included presence of a ventricular septal defect, a bicuspid aortic valve, and coarctation of the aorta. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319810PMC

Staphylococcus lugdunensis: Review of Epidemiology, Complications, and Treatment.

Cureus 2020 Jun 24;12(6):e8801. Epub 2020 Jun 24.

Internal Medicine, University of Louisville, Louisville, USA.

is a species of coagulase-negative staphylococci (CNS) that induces a variety of infectious diseases, including skin and soft tissue infection (SSTI), infective endocarditis (IE), and bone and PJI. This review article underscores the important points in the literature about infections, including its epidemiology, diagnosis, and treatment, as well as specific types of infections it can cause. Anatomical and age-related distributions of SSTIs have been noted, though they most commonly occur as abscesses. Read More

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http://dx.doi.org/10.7759/cureus.8801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325404PMC

Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population.

Cureus 2020 May 28;12(5):e8338. Epub 2020 May 28.

Medicine and Pathology: Laboratory, University of Alberta, Edmonton, CAN.

Background Infective endocarditis (IE) is an uncommon disease with an involved interplay of clinical and surgical team management. We aimed to define diagnosis parameters and delineate in-hospital management in patients with IE admitted in a tertiary hospital of Southern Italian. Materials and methods Fifty-six consecutive patients (42 males, 14 females; age range: 34-85 years) admitted for IE in the Infectious Diseases, Cardiac Surgery, and Cardiology units, between January 2011 and August 2017, were enrolled. Read More

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http://dx.doi.org/10.7759/cureus.8338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325401PMC

Contemporary Outcomes of Pulmonary Valve Endocarditis: A 16-Year Single Centre Experience.

Heart Lung Circ 2020 Jun 11. Epub 2020 Jun 11.

Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Limited data exist regarding the clinical characteristics and contemporary outcomes of patients with pulmonary valve (PoV) infective endocarditis (IE).

Methods: This is a retrospective cohort study of patients with a confirmed diagnosis of IE affecting the PoV at our centre between January 2002 and October 2018. Electronic medical records were reviewed to gather the clinical and echocardiographic variables. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.04.015DOI Listing

Duration of Pre-Operative Antibiotic Treatment and Culture Results in Patients With Infective Endocarditis.

J Am Coll Cardiol 2020 Jul;76(1):31-40

Institute for Infectious Diseases, University of Bern, Bern, Switzerland. Electronic address:

Background: Bacterial growth in cultures of resected heart valves of patients with infective endocarditis (IE) is influenced by pre-operative antibiotic treatment (preop-AT).

Objectives: This study sought to evaluate the time dependency of valve culture results (positive valve culture [PVC] vs. negative valve culture) on preop-AT. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.04.075DOI Listing

Impact of the Novel Prophage ϕSA169 on Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection.

mSystems 2020 Jun 30;5(3). Epub 2020 Jun 30.

The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA

Persistent methicillin-resistant (MRSA) endovascular infections are life-threatening syndromes with few therapeutic options. The potential impact of bacteriophages on the persistent outcome has not been well studied. In this study, we investigated the role of a novel prophage (ϕSA169) in MRSA persistence by using a lysogen-free clinically resolving bacteremia (RB) isolate and comparing it to a derivative which was obtained by infecting the RB strain with ϕSA169, which has been lysogenized in a clinical persistent MRSA bacteremia (PB) isolate. Read More

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http://dx.doi.org/10.1128/mSystems.00178-20DOI Listing

From Infectious Endocarditis to Ventricular Pseudo-Aneurysm.

Circ Cardiovasc Imaging 2020 Jul 1;13(7):e010265. Epub 2020 Jul 1.

Cardiac Surgery Department (Y.B., M.F., L.C., N.d'O.), University Hospital, Clermont-Ferrand, France.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.010265DOI Listing

Treatment of osteoarticular, cardiovascular, intravascular catheter-related, and other complicated infections with dalbavancin and oritavancin: a systematic review.

Int J Antimicrob Agents 2020 Jun 27:106069. Epub 2020 Jun 27.

University of Georgia College of Pharmacy, Albany, GA, 31701, USA. Electronic address:

Background: There is increasing interest in using oritavancin and dalbavancin for complicated Gram-positive infections as an alternative to in-hospital intravenous or outpatient antimicrobial therapy.

Objective: To evaluate the efficacy and safety of long-acting lipoglycopeptides (laLGPs) in patients with osteoarticular, cardiovascular, intravascular catheter-related, and other complicated infections.

Methods: A systematic literature search using was performed using "dalbavancin" and "oritavancin" as search terms. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106069DOI Listing

Pulmonic valve infective endocarditis: transesophageal echocardiography is critical to diagnosis.

Infect Dis (Lond) 2020 Jun 30:1-3. Epub 2020 Jun 30.

Department of Internal Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1080/23744235.2020.1784996DOI Listing

Early differentiation between uncomplicated and complicated Staphylococcus aureus bacteraemia: potential value and limitations of a clinical risk score.

Int J Clin Pract 2020 Jun 30:e13601. Epub 2020 Jun 30.

Department of Infectious Diseases, Leiden university Medical Center.

Objective: A cornerstone in the management of Staphylococcus aureus bacteraemia (SAB) is the differentiation between a complicated and an uncomplicated SAB course. The ability to early and accurately identify patients with - and without - complicated bacteraemia may optimize the utility of diagnostics and prevent unnecessary prolonged antibiotic therapy.

Methods: Development and validation of a prediction score in SAB using demographic, clinical, and laboratory data from 2 independent Dutch cohorts; estimating the risk of complicated disease at the time of the first positive blood culture. Read More

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http://dx.doi.org/10.1111/ijcp.13601DOI Listing

Development and validation of a dosing nomogram for amoxicillin in infective endocarditis.

J Antimicrob Chemother 2020 Jun 30. Epub 2020 Jun 30.

Clinical Pharmacology Department, CHU Nantes, Nantes, France.

Background: Amoxicillin is the first-line treatment for streptococcal or enterococcal infective endocarditis (IE) with a dose regimen adapted to weight.

Objectives: Covariates influencing pharmacokinetics (PK) of amoxicillin were identified in order to develop a dosing nomogram based on identified covariates for individual adaptation.

Patients And Methods: Patients treated with amoxicillin administered by continuous infusion for IE were included retrospectively. Read More

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http://dx.doi.org/10.1093/jac/dkaa232DOI Listing

Asymptomatic central line-associated bloodstream infections in children implanted with long term indwelling central venous catheters in a teaching hospital, Sri Lanka.

BMC Infect Dis 2020 Jun 29;20(1):457. Epub 2020 Jun 29.

Department of Microbiology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Microbiology, Saliyapura, Sri Lanka.

Background: Indwelling central venous catheters (CVC) are used to provide long term hemodialysis. The commonest and the severe complication of CVC is the central line-associated bloodstream infection (CLABSI). This study was done to assess the etiology and infectious complications of CVC in children on long term hemodialysis. Read More

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http://dx.doi.org/10.1186/s12879-020-05190-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325288PMC

Munich Comparative Study: Prospective Long-Term Outcome of the Transcatheter Melody Valve Versus Surgical Pulmonary Bioprosthesis With Up to 12 Years of Follow-Up.

Circ Cardiovasc Interv 2020 Jul;13(7):e008963

Department of Pediatric Cardiology and Congenital Heart Disease (S.G., P.E., A.E., A.H., C.M., D.T.), German Heart Center Munich, Technische Universität München.

Background: Percutaneous pulmonary valve implantation (PPVI) has become an important treatment of right ventricular outflow tract dysfunction. Studies directly comparing the long-term outcome of PPVI with the Melody valve to surgical pulmonary valve replacement (SPVR) are lacking.

Methods: All patients treated with PPVI with the Melody valve and SPVR between January 2006 and December 2018 in our center were enrolled into a database and investigated with a standard follow-up protocol. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008963DOI Listing

Optimizing outcomes in infective endocarditis: A comprehensive literature review.

J Card Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, School of Medicine, University of Liverpool, Liverpool, UK.

Background: Despite being rare, infective endocarditis (IE) is a life-threatening disease with poor prognosis. New diagnostic and therapeutic strategies are emerging; however, predisposing factors and microbiology of the disease are also changing with time. Because of this, there has been a lack of reduction in the disease's incidence and new challenges for clinicians have arisen such as an increasingly aging population and growing antimicrobial resistance. Read More

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http://dx.doi.org/10.1111/jocs.14656DOI Listing

Echocardiographic Characteristics of Subjects With COVID-19: A Case Series.

Cardiol Res 2020 Aug 3;11(4):260-265. Epub 2020 Jun 3.

Cardiology Department, Hospital Universitario, Universidad Autonoma de Nuevo Leon (UANL), Nuevo Leon, Mexico.

Although coronavirus disease 2019 (COVID-19) manifests in most cases with respiratory symptoms, other presentations can occur. Direct damage to the cardiovascular system has been reported and recently, acute myocardial injury has been identified as a risk factor for mortality. Transthoracic echocardiography is a non-invasive tool that allows the detection of myocardial damage with validated markers (left ventricular ejection fraction and global longitudinal strain). Read More

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http://dx.doi.org/10.14740/cr1084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295558PMC

Ceftriaxone treatment of spondylodiscitis and other serious infections with Cutibacterium acnes.

J Antimicrob Chemother 2020 Jun 26. Epub 2020 Jun 26.

Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.

Objectives: To establish testing and treatment recommendations for a ceftriaxone once-daily dose regimen for systemic infections with Cutibacterium acnes.

Methods: A review of the literature and a retrospective evaluation of patients diagnosed with C. acnes spondylodiscitis and treated with ceftriaxone were performed. Read More

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http://dx.doi.org/10.1093/jac/dkaa259DOI Listing

Antiplatelet Agents Have a Distinct Efficacy on Platelet Aggregation Induced by Infectious Bacteria.

Front Pharmacol 2020 5;11:863. Epub 2020 Jun 5.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU Méditerranée infection, Marseille, France.

Platelets are the cornerstone of hemostasis. However, their exaggerated aggregation induces deleterious consequences. In several diseases, such as infectious endocarditis and sepsis, the interaction between platelets and bacteria leads to platelet aggregation. Read More

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http://dx.doi.org/10.3389/fphar.2020.00863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291881PMC

Prospective Validation of PREDICT and its Impact on the Transesophageal Echocardiography Use in Management of Staphylococcus aureus Bacteremia.

Clin Infect Dis 2020 Jun 22. Epub 2020 Jun 22.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic Rochester, Minnesota.

Background: Infective endocarditis (IE) is the most feared complication of Staphylococcus aureus bacteremia (SAB). Transesophageal echocardiogram (TEE) is generally recommended for all patients with SAB, however, supporting data for this are limited. We previously developed a scoring system, "PREDICT", that quantifies the risk of IE and identifies patients who would benefit the most from undergoing TEE. Read More

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http://dx.doi.org/10.1093/cid/ciaa844DOI Listing

Gentamicin Vestibulotoxicity: Further Insights From a Large Clinical Series.

Otol Neurotol 2020 Jun 16. Epub 2020 Jun 16.

Department of Otolaryngology-Head and Neck Surgery, University Health Network.

Objective: To review insights gained from a 21-year experience with gentamicin-induced vestibulotoxicity including differences in vestibulotoxicity between single daily dosing (SDD) and multiple daily dosing (MDD) regimens.

Study Design: Retrospective case series.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002698DOI Listing

Single Photon Emission Tomography in the Diagnostic Assessment of Cardiac and Vascular Infectious Diseases.

Curr Radiopharm 2020 Jun 21. Epub 2020 Jun 21.

Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria. South Africa.

Background: Cardiac and vascular infection is a arising cause of mortality and morbidity in the adult population. Diagnosis based on culture and anatomic imaging is frequently inconclusive. Radiolabeled leucocyte scintigraphy plays a useful role in the diagnosis and management of these serious infectious conditions. Read More

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http://dx.doi.org/10.2174/1874471013666200621190001DOI Listing

Hospital Costs of Injection Drug Use in Florida.

Clin Infect Dis 2020 Jun 21. Epub 2020 Jun 21.

Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

People who inject drugs (PWID) experience significant injection related infections (IRI) at significant healthcare system cost. This article utilizes and validates an ICD-10 based algorithm to estimate hospitalized PWID populations, assess the total statewide morbidity of IRI among PWID, and calculates associated costs of care. Read More

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http://dx.doi.org/10.1093/cid/ciaa823DOI Listing

Long-term follow-up of the Shelhigh™ SuperStentless bioprosthesis aortic valve and valved conduit in a monocentric experience.

J Cardiovasc Surg (Torino) 2020 Jun 19. Epub 2020 Jun 19.

Division of Thoracic and Cardiovascular Surgery, Pontchaillou University Hospital Center, Rennes, France.

Background: The Shelhigh™ SuperStentless (Shelhigh, INC., Union, United States) is a stentless aortic valve bioprosthesis and aortic root valved conduit. In 2007, this device was recalled by FDA due to malfunction, and subsequently reintegrated by BioIntegral Surgical™ Few data are available over late durability of this device. Read More

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http://dx.doi.org/10.23736/S0021-9509.20.11219-9DOI Listing

Fungal endocarditis in transplant recipients: a systematic review.

Mycoses 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Invasive fungal infections remain a major cause of morbidity and mortality in transplant recipients. Moreover, Fungal Infective Endocarditis (FIE) is a rare infection that carries a higher mortality than bacterial IE in normal host, while in transplant recipients may be even higher. The purpose of this study was to systemically review all published cases of FIE in solid organ and allogeneic bone marrow transplant recipients, describe the epidemiology, microbiology, clinical characteristics, treatment and outcomes of these infections, and to identify risk factors for mortality by FIE. Read More

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http://dx.doi.org/10.1111/myc.13132DOI Listing

Infective Endocarditis After Transcatheter Aortic Valve Replacement.

J Am Coll Cardiol 2020 Jun;75(24):3020-3030

Department of Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Aarau, Switzerland.

Background: Infective endocarditis may affect patients after transcatheter aortic valve replacement (TAVR).

Objectives: The purpose of this study was to provide detailed information on incidence rates, types of microorganisms, and outcomes of infective endocarditis after TAVR.

Methods: Between February 2011 and July 2018, consecutive patients from the SwissTAVI Registry were eligible. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.04.044DOI Listing

Lead Extraction for Cardiovascular Implantable Electronic Device Infection in Patients With Left Ventricular Assist Devices.

JACC Clin Electrophysiol 2020 Jun 29;6(6):672-680. Epub 2020 Apr 29.

Division of Electrophysiology, Duke University Medical Center, Durham, North Carolina. Electronic address:

Objectives: The goal of this study was to assess the utility of transvenous lead extraction for cardiovascular implantable electronic device (CIED) infection in patients with a left ventricular assist device (LVAD).

Background: The use of transvenous lead extraction for the management CIED infection in patients with a durable LVAD has not been well described.

Methods: Clinical and outcomes data were collected retrospectively among patients who underwent lead extraction for CIED infection after LVAD implantation at Duke University Hospital. Read More

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http://dx.doi.org/10.1016/j.jacep.2020.02.006DOI Listing

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016.

BMC Infect Dis 2020 Jun 18;20(1):428. Epub 2020 Jun 18.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province, China.

Background: To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years.

Methods: A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective endocarditis were included. Read More

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http://dx.doi.org/10.1186/s12879-020-05153-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301995PMC

Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components.

JCI Insight 2020 Jun 16. Epub 2020 Jun 16.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America.

Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization. We used high-resolution mass spectrometry to define the proteome of staphylococcal and non-staphylococcal vegetations and Terminal Amine Isotopic Labeling of Substrates (TAILS) to define their proteolytic landscapes. These approaches identified over 2000 human proteins in staphylococcal and non-staphylococcal vegetations. Read More

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http://dx.doi.org/10.1172/jci.insight.135317DOI Listing

Matched retrospective study of infective endocarditis among solid organ transplant recipients compared to non-transplant: Seven-year experience in a US Referral Center.

Transpl Infect Dis 2020 Jun 15:e13368. Epub 2020 Jun 15.

Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Infective endocarditis (IE) is a rare complication following solid organ transplant (SOT); data on the clinical features and outcomes of IE in SOT recipients in the modern era are limited.

Methods: We conducted a single-center retrospective cohort study of IE diagnosed from 1/2008-12/2014 in SOT recipients, who were matched by age and microorganism to cases of IE in non-SOT, to describe the clinical features and outcomes.

Results: There were 14 cases of IE identified in SOT recipients matched to 56 non-SOT controls. Read More

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http://dx.doi.org/10.1111/tid.13368DOI Listing

The Role of 18-F FDG PET/CT in Imaging of Endocarditis and Cardiac Device Infections.

Semin Nucl Med 2020 Jul 8;50(4):319-330. Epub 2020 Apr 8.

Division of Infectious Disease, Department of Medicine, Mayo Clinic, Rochester, MN.

Cardiovascular infections are associated with significant morbidity and mortality, particularly when there is a delay in diagnosis and initiation of appropriate therapy. Echocardiography is currently the first line imaging study for endocarditis and cardiac device infections. However its sensitivity is limited in the presence of prosthetic material and changes may not be apparent until there is structural damage from the infectious process. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2020.03.003DOI Listing

Surgical infective endocarditis and concurrent splenic abscess requiring splenectomy: a case series and review of the literature.

Diagn Microbiol Infect Dis 2020 May 17;97(4):115082. Epub 2020 May 17.

Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Splenic abscess is an uncommon but serious complication of infective endocarditis (IE). The timing of surgical management of splenic abscess can be challenging when valve surgery is required. The American Heart Association (AHA) and the European Society of Cardiology (ESC) currently recommends splenectomy before valve replacement due to fear of reinfection of the heart valve; however, published data to support this recommendation are limited. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115082DOI Listing

[Hemoglobin drop after thrombolytic therapy in a 57-year-old stroke patient with "erosive gastritis"].

Internist (Berl) 2020 Jul;61(7):746-753

Gastroenterologie, Marien-Hospital Euskirchen, Gottfried-Disse-Str. 40, 53879, Euskirchen, Deutschland.

A 57-year-old woman underwent esophagogastroduodenoscopy due to a continuous drop in hemoglobin levels reaching 7.4 g/dl after treatment with intravenous thrombolytic therapy 1 week earlier because of an ischemic insult. Numerous erosive lesions were found in the gastric corpus. Read More

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http://dx.doi.org/10.1007/s00108-020-00818-9DOI Listing

Potential benefit of combination antifungal therapy in endocarditis.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia

endocarditis (AE) is a rare condition with a mortality rate greater than 60%. While it is generally accepted that both antifungal therapy and surgery are necessary for survival, the optimal antifungal regimen is unclear. A 62-year-old man was diagnosed with AE of a prosthetic aortic valve, complicated by cerebral emboli. Read More

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http://dx.doi.org/10.1136/bcr-2019-234008DOI Listing

Infective endocarditis at a tertiary-care hospital in China.

J Cardiothorac Surg 2020 Jun 10;15(1):135. Epub 2020 Jun 10.

Department of Cardiac Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Background: The aim of this study was to describe the clinical features and outcome of infective endocarditis at a general hospital in China and to identify the risk factors associated with in-hospital mortality.

Methods: A retrospective study was conducted and all patients diagnosed with definite or possible infective endocarditis between January 2013 and June 2018 according to the modified Duke criteria were included.

Results: A total of 381 patients were included. Read More

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http://dx.doi.org/10.1186/s13019-020-01183-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285574PMC

Molecular detection of Coxiella burnetii in livestock farmers and cattle from Magdalena Medio in Antioquia, Colombia.

PLoS One 2020 10;15(6):e0234360. Epub 2020 Jun 10.

Escuela de Ciencias de la Salud, Facultad de Medicina, Grupo Biología de Sistemas, Universidad Pontificia Bolivariana, Medellín, Antioquia, Colombia.

Coxiella burnetii causes Q fever in humans and coxiellosis in animals. In humans, it causes acute febrile illnesses like influenza, pneumonia, hepatitis, and chronic illnesses such as endocarditis, vascular infection, and post-infectious fatigue syndrome. It is widely distributed worldwide, and its main reservoirs are sheep, goats, and cattle. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234360PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286501PMC

Changing the Focus to the Whole Patient instead of One Oral Disease: The Concept of Individualized Prevention.

Adv Prev Med 2020 20;2020:6752342. Epub 2020 May 20.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.

Oral diseases are highly prevalent and a global burden. Accordingly, their prevention appears essential. Recently, different strategies have been developed, mainly focusing on the presence of singular oral diseases or conditions. Read More

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http://dx.doi.org/10.1155/2020/6752342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256733PMC

COVID-19: from epidemiology to treatment.

Eur Heart J 2020 06;41(22):2092-2112

Infectious Diseases Department, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain.

The COVID-19 pandemic has greatly impacted the daily clinical practice of cardiologists and cardiovascular surgeons. Preparedness of health workers and health services is crucial to tackle the enormous challenge posed by SARS-CoV-2 in wards, operating theatres, intensive care units, and interventionist laboratories. This Clinical Review provides an overview of COVID-19 and focuses on relevant aspects on prevention and management for specialists within the cardiovascular field. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279517PMC

Different Types of Coagulase Are Associated With 28-Day Mortality in Patients With Bloodstream Infections.

Front Cell Infect Microbiol 2020 19;10:236. Epub 2020 May 19.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

, a leading cause of bacteremia and infective endocarditis, exploits the human coagulation system by using a wide range of specific virulence factors. However, the impact of these host-pathogen interactions on the outcome of patients with bacteremia (SAB) remains unclear. A total of 178 patients with bacteremia were included and analyzed regarding bacterial factors ( gene size, and clinical parameters. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248564PMC

Obstructive heart failure with infective endocarditis.

IDCases 2020 29;21:e00845. Epub 2020 May 29.

Department of Infectious Diseases, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL, USA.

We illustrate the progression of infective endocarditis in a patient with a bioprosthetic mitral valve and decompensated heart failure secondary to an obstructive septic vegetation. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264758PMC

Risk factors of infective endocarditis in persons who inject drugs.

Harm Reduct J 2020 Jun 5;17(1):35. Epub 2020 Jun 5.

Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

Background: The rising incidence of infective endocarditis (IE) among people who inject drugs (PWID) has been a major concern across North America. The coincident rise in IE and change of drug preference to hydromorphone controlled-release (CR) among our PWID population in London, Ontario intrigued us to study the details of injection practices leading to IE, which have not been well characterized in literature.

Methods: A case-control study, using one-on-one interviews to understand risk factors and injection practices associated with IE among PWID was conducted. Read More

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http://dx.doi.org/10.1186/s12954-020-00378-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275611PMC

Objective cognitive performance and subjective complaints in patients with chronic Q fever or Q fever fatigue syndrome.

BMC Infect Dis 2020 Jun 5;20(1):397. Epub 2020 Jun 5.

Department of Medical Psychology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Primary aim of this study was to compare cognitive performance of patients with chronic Q fever or Q fever fatigue syndrome (QFS) to matched controls from the general population, while taking performance validity into account. Second, we investigated whether objective cognitive performance was related to subjective cognitive complaints or psychological wellbeing.

Methods: Cognitive functioning was assessed with a neuropsychological test battery measuring the domains of processing speed, episodic memory, working memory and executive functioning. Read More

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http://dx.doi.org/10.1186/s12879-020-05118-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275429PMC

Recommendations on Securing Microbiological Specimens to Guide the Multidisciplinary Management of Infective Native Aortic Aneurysms.

Ann Vasc Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiology, Rigshospitalet, Copenhagen, and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Background: The absence of recommendations for the systematic collection of microbiological specimens to help determine the management of infective native aortic aneurysms (INAAs) may lead to diagnostic difficulty and sub-optimal antibiotic treatment. In this review, we attempt to establish recommendations in the field by identifying current strategies for the diagnosis and management of INAA and comparing them with those for infective endocarditis (IE).

Methods: A systematic literature review of Medline and ScienceDirect databases was performed using PRISMA methodology to identify guidelines for the management of INAA. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.059DOI Listing

Acute convexity subarachnoid hemorrhage (cSAH) in infectious endocarditis (IE): imaging features and follow-up.

J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Bichat Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Aim: To assess: (1) the prevalence of convexity subarachnoid hemorrhage (cSAH) in infective endocarditis (IE); (2) its relationship with IE features; (3) the associated lesions; (4) whether cSAH is a predictor of future hemorrhage; (5) whether cSAH could cause cortical superficial siderosis (cSS).

Methods: We retrospectively evaluated the MRI data in 240 IE-patients: At baseline, the location of cSAH and associated lesions; at follow-up, the occurrence of new lesions and of cSS. Patients with and without cSAH were compared. Read More

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http://dx.doi.org/10.1007/s00415-020-09953-7DOI Listing

Infective Endocarditis During the Infectious Diseases and Substance Use Disorder Syndemic: A Six-Year Case Series.

Open Forum Infect Dis 2020 May 25;7(5):ofaa142. Epub 2020 Apr 25.

Department of Pharmacy Maine Medical Center, Portland, Maine, USA.

Treatment for infective endocarditis (IE) has not been extensively studied in the setting of rising injection drug use. There were 12 cases of IE at the Maine Medical Center between 2013 and 2018. The patient characteristics, treatment regimens, and outcomes were retrospectively analyzed. Read More

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http://dx.doi.org/10.1093/ofid/ofaa142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252282PMC

Insidious postoperative Aspergillus niger graft aortitis.

IDCases 2020 16;21:e00823. Epub 2020 May 16.

Città della Salute e della Scienza di Torino, University of Turin, Department of Surgical Sciences, Division of Cardiac Surgery, Italy.

Fungal endocarditis/aortitis is an uncommon yet emerging entity accounting for 2% to 4% of all cases of infective endocarditis and continues to be associated with a poor prognosis. We present the first case of polyethylene-terephthalate (PETE) graft aortitis caused by , a rare fungal agent. Early diagnosis with frequent transoesophageal echocardiography (TEE) and a prompt surgical intervention coupled with optimal antifungal therapy are still the only option to reduce the exceedingly high mortality and morbidity. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256640PMC

Granulicatella Causing Infective Endocarditis and Glomerulonephritis.

IDCases 2020 11;21:e00792. Epub 2020 May 11.

Department of Nephrology, UConn Health Center, Farmington, CT, United States.

Granulicatella is a type of nutritionally variant Streptococcus (NVS) that requires special medium for growth. It has shown to cause infective endocarditis which is associated with higher mortality and complications. We present a case of Granulicatella causing endocarditis and glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256654PMC

The diagnostic benefit of 16S rDNA PCR examination of infective endocarditis heart valves: a cohort study of 146 surgical cases confirmed by histopathology.

Clin Res Cardiol 2020 Jun 2. Epub 2020 Jun 2.

Division Hospital and Environmental Hygiene, Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.

Aims: Upon suspicion of infective endocarditis, the causative microorganism must be identified to optimize treatment. Blood cultures and culturing of removed valves are the mainstay of this diagnosis and should be complemented by growth-independent methods. We assessed the diagnostic benefit of examining removed endocarditis valves by broad-range bacterial PCR to detect causative bacteria in cases where culturing was not available, negative, or inconclusive because a skin commensal was detected, in patients from our clinical routine practice. Read More

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http://dx.doi.org/10.1007/s00392-020-01678-xDOI Listing

Impact of systematic whole-body 18F-fluorodeoxyglucose PET/CT on the management of patients suspected of infective endocarditis: the prospective multicenter TEPvENDO study.

Clin Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Inserm CIC 1425, Paris, France.

Background: Diagnostic and patients' management modifications induced by whole-body 18F-FDG-PET/CT had not been evaluated so far in prosthetic valve (PV) or native valve (NV) infective endocarditis (IE)-suspected patients.

Methods: 140 consecutive patients in 8 tertiary care hospitals underwent 18F-FDG-PET/CT. ESC-2015-modified Duke criteria and patients' management plan were established jointly by two experts before 18F-FDG-PET/CT. Read More

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http://dx.doi.org/10.1093/cid/ciaa666DOI Listing

Systematic Whole Body 18F-FDG PET/CT in Infective Endocarditis: Are We There Yet?

Clin Infect Dis 2020 Jun 1. Epub 2020 Jun 1.

Division of Infectious Diseases, Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA.

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http://dx.doi.org/10.1093/cid/ciaa665DOI Listing