562 results match your criteria Infectious Disorders - Drug Targets[Journal]


Molecular Binding and Simulation Studies of Staphylococcus aureus Superantigens with Flavonoid Compounds.

Infect Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Department of Integrative Biology, VIT, Vellore, Tamil nadu, 632 014. India.

Superantigens of Staphylococcus aureus namely enterotoxin A, exfoliative toxin A, and Toxic shock syndrome toxin-1 cause detrimental effects on the cells of immune system. In this work, the toxins were downloaded from Protein DataBank database and energy minimized using KoBaMIN server. Forty flavonoids compounds were identified by pubchem compound database through extensive literature study and their 3D structures were obtained by submitting SMILES to CORINA tool. Read More

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http://dx.doi.org/10.2174/1871526519666190207092307DOI Listing
February 2019
2 Reads

Plasmid-Mediated Quinolone Resistance in Pseudomonas aeruginosa Isolated from Burn Patients in Tehran, Iran.

Infect Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Student Research Committee, Qazvin University of Medical Sciences, Qazvin. Iran.

Introduction: Plasmid-induced quinolone resistance has raised a great concern in the treatment of serious infections worldwide. The aims of this study were to determine the antibiotic susceptibility, the frequency of qepA, aac(6')-Ib, and qnr genes by PCR and sequencing, and typing of the resistant isolates using repetitive extragenic palindromic sequence-based PCR (REP-PCR) in Pseudomonas aeruginosa isolated from burn wound infections.

Material And Methods: In the current cross-sectional study, 149 P. Read More

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http://dx.doi.org/10.2174/1871526519666190206205521DOI Listing
February 2019
12 Reads

Non-compliance to mass drug administration associated with the low perception of the community members about their susceptibility to lymphatic filariasis in Ankobra, Ghana.

Infect Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

School of Public Health (SPH), University of Ghana, Legon, Accra. Ghana.

Background: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high (4.5%). Read More

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http://dx.doi.org/10.2174/1871526519666190206210808DOI Listing
February 2019

Antimicrobial Resistance and Presence of Cass 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children With Diarrhea In Tehran, Iran.

Infect Disord Drug Targets 2019 Jan 30. Epub 2019 Jan 30.

Divison of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran. Iran.

Background: Salmonellosis is a major food-borne disease worldwide. The increasing prevalence of antimicrobial resistance among food-borne pathogens such as Salmonella spp. is concerning. Read More

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http://dx.doi.org/10.2174/1871526519666190130171020DOI Listing
January 2019
1 Read

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

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http://dx.doi.org/10.2174/1871526519666190128102039DOI Listing
January 2019
2 Reads

Post-Traumatic Endophthalmitis due to Acinetobacter radioresistens: Virulence Potential of Commensal Bacteria.

Infect Disord Drug Targets 2019 Jan 23. Epub 2019 Jan 23.

Department of Microbiology, Government Medical College and Hospital, Sector 32, Chandigarh. India.

Acinetobacter species are widely distributed in soil, water and hospital environment. In addition to A. calcoaceticus-baumannii complex, the clinically most relevant species, there are other genomospecies which are less frequently identified, mostly due to lack of accurate methods for routine identification. Read More

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http://dx.doi.org/10.2174/1871526519666190123145321DOI Listing
January 2019
3 Reads

Hepatitis C virus: Efficacy of new DAAs Regimens.

Infect Disord Drug Targets 2019 Jan 20. Epub 2019 Jan 20.

Tropical Medicine Department, Tanta University. Egypt.

Background: HCV treatment showed dramatical change due to the introduction of potent strong direct antiviral drugs. Before the appearance of Direct-acting antivirals, multiple therapeutic interventions were used for hepatitis C, but none of these interventions were effective on patient-centered outcomes. Direct-acting antivirals cause disruption of viral replication because they target specific nonstructural viral proteins. Read More

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http://dx.doi.org/10.2174/1871526519666190121114003DOI Listing
January 2019
1 Read

Distribution of genes encoding iron uptake systems among the Escherichia coli isolates from foodstuffs compared to Escherichia coli isolated from clinical specimens.

Infect Disord Drug Targets 2019 Jan 18. Epub 2019 Jan 18.

Department of Microbiology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan. Iran.

Introduction: Bacteria are requiring iron ions to grow and infect the host, which, by using iron uptake systems, acquire free iron from their host cell. Escherichia coli is one of the most important pathogens causing food poisoning and clinical infections. The aim of this study was to assess the genes encoding iron uptake systems in food samples compared to clinical specimens. Read More

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http://dx.doi.org/10.2174/1871526519666190119112542DOI Listing
January 2019
1 Read

Legionella pneumonia in pregnancy: A case report and review of the literature.

Infect Disord Drug Targets 2019 Jan 18. Epub 2019 Jan 18.

Burrell College of Osteopathic Medicine, Department of Medicine, Section of Infectious Diseases Las Cruces, New Mexico. United States.

L. pneumophila is an unusual cause of pneumonia with a prevalence of 2.7%, and it is even more uncommon in pregnancy [1]. Read More

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http://dx.doi.org/10.2174/1871526519666190119110657DOI Listing
January 2019

Phenotypic and Molecular Survey of Metallo-beta-lactamase-producing Pseudomonas aeruginosa Isolated from Patients with Nosocomial and Non-Nosocomial Infections.

Infect Disord Drug Targets 2019 Jan 18. Epub 2019 Jan 18.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj. Iran.

Background: Resistance to antimicrobial agents in Pseudomonas aeruginosa (P. aeruginosa) including carbapenems is a prominent problem in patients. Aim of this study is surveying metallo-beta-lactamase (MBL)-producing P. Read More

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http://dx.doi.org/10.2174/1871526519666190119113328DOI Listing
January 2019

Trichomonas Vaginalis Infection among Women Attending laboratory Centers in Ilam, Iran.

Infect Disord Drug Targets 2019 Jan 17. Epub 2019 Jan 17.

Department of Parasitology, school of medicine, Ilam University of Medical Sciences, Ilam. Iran.

Trichomoniasis is known as a common venereal disease. It is estimated that 180 million people in the world are infected with this disease. The present study was conducted to estimate the prevalence of (Trichomonas vaginalis) T. Read More

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http://www.eurekaselect.com/169077/article
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http://dx.doi.org/10.2174/1871526519666190117120705DOI Listing
January 2019
3 Reads

Hydroxyenone Derivatives: In vitro Anti-malarial and Docking Studies against P. falciparum.

Infect Disord Drug Targets 2019 Jan 15. Epub 2019 Jan 15.

Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana. India.

A series of 1-{2-(prop-2-ynyloxy)aryl}-3-hydroxy-3-(4'-trifluoromethyl-phenyl)prop-2-en-1-ones obtained by photo-irradiation of 2-{2-(prop-2-ynyloxy)benzoyl}-3-(4-trifluoromethyl-phenyl)oxiranes (that were characterized by spectral studies: FT-IR, 1H NMR, 13C NMR and Mass analysis) was screened for the anti-malarial activity by evaluating against chloroquine-sensitive P. falciparum (CD7). The molecular docking studies using AutoDock Vina were also performed to further ascertain the efficacy of these compounds with PDB:4ORM. Read More

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http://dx.doi.org/10.2174/1871526519666190116110108DOI Listing
January 2019

PZQ therapy: how close are we in the development of effective alternative anti-schistosomal drugs?

Infect Disord Drug Targets 2018 Dec 31. Epub 2018 Dec 31.

Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886. South Africa.

Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. Read More

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http://dx.doi.org/10.2174/1871526519666181231153139DOI Listing
December 2018
3 Reads

Stopping of the downtrend of Tuberculosis in Iran, a systematic review of associated risk factors.

Infect Disord Drug Targets 2018 Dec 28. Epub 2018 Dec 28.

Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz. Iran.

Tuberculosis (TB) is a public health problem in developing countries. In recent decades, the incidence of the disease has been gradually reducing in Iran. However, the reducing incidence of the disease has stopped in the country during recent years. Read More

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http://dx.doi.org/10.2174/1871526519666181228162837DOI Listing
December 2018

Characterization of Antibacterial-Producing Endophytic Fungi of Syzygiumpolyanthum Leaves.

Infect Disord Drug Targets 2018 Dec 26. Epub 2018 Dec 26.

Faculty of Pharmacy, Hasanuddin University. Indonesia.

Endophytic fungi lives in plants tissue and can produce the same bioactive compounds as its host plant produces. Syzygiumpolyanthum leaves have known to be one of the antibacterial compound producer. This study aimed to characterize morphologically, microscopically, and molecularly the antibacterial-producing endophytic fungi of Syzygiumpolyanthum leaves. Read More

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http://dx.doi.org/10.2174/1871526519666181226123541DOI Listing
December 2018
5 Reads

Association of Low Vitamin D Status with Complications of HIV and AIDS: A Literature Review.

Infect Disord Drug Targets 2018 Dec 21. Epub 2018 Dec 21.

Department HIV Medicine, Coventry & Warwickshire Partnership Trust. United Kingdom.

With the advent of combination antiretroviral therapy (cART) the survival of HIV patients have improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. Read More

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http://dx.doi.org/10.2174/1871526519666181221122731DOI Listing
December 2018
1 Read

Association Between Immunologic and Virologic Functioning and Health-Related Quality of Life Among People Living with HIV, Tehran, Iran.

Infect Disord Drug Targets 2018 Dec 21. Epub 2018 Dec 21.

Iranian research center for HIV/AIDS(IRCHA), Tehran University of Medical Sciences. Iran.

Background: With recent progress in the treatment of people living with HIV (PLWH) and their increased rate of survival, health-related quality of life (HRQoL) has become an important issue.

Objective: In the present study, we aimed to investigate the association of current CD4 cell count, baseline CD4 cell count, nadir CD4 cell count, and plasma viral load with health-related quality of life in people living with HIV (PLWH).

Methods: Participants were 67 PLWH who were under the treatment of antiretroviral therapy in Imam Khomeini Hospital of Tehran, Iran in 2016. Read More

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http://dx.doi.org/10.2174/1871526519666181221123932DOI Listing
December 2018

Outcomes of Treatment and Predictors of Response to Sofosbuvir plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection.

Infect Disord Drug Targets 2018 Dec 17. Epub 2018 Dec 17.

Department of Tropical Medicine & Infectious Diseases, Faculty of Medicine, Tanta University, Tanta. Egypt.

Background & Aims: Treatment plan of chronic HCV infection has dramatically improved after the introduction of different groups of direct-acting antiviral (DAA) drugs. These drugs have been found to be safe and effective. Sofosbuvir (SOF) plus simeprevir (SMV) regimen has been shown to be tolerable and effective in treatment of patients with HCV genotype 1. Read More

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http://dx.doi.org/10.2174/1871526519666181218104600DOI Listing
December 2018

Synthesis, biological evaluation and molecular docking studies of new pyrazolines as an antitubercular and cytotoxic agents.

Infect Disord Drug Targets 2018 Dec 17. Epub 2018 Dec 17.

Vignan Pharmacy College, Vadlamudi, Guntur. India.

A series of new pyrazolines containing 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M. tuberculosis H37Rv strain and in vitro anticancer activity against DU-145 prostate cancer cell lines. Majority of screened compounds have displayed potential activity against Mycobacterium tuberculosis H37Rv(MTB) strain and anticancer activity against DU-149 prostate cancer cell lines. Read More

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http://www.eurekaselect.com/168392/article
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http://dx.doi.org/10.2174/1871526519666181217120626DOI Listing
December 2018
2 Reads

Incidence and risk factors of brucellosis in Kermanshah province, Iran during 2010-2014.

Infect Disord Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Infectious diseases research center, AJA University of medical sciences, Tehran. Iran.

Introduction: Incidence of brucellosis was growing up in Iran during the past years. Kermanshah province-west of Iran is one of the endemic regions of the disease. The aim of this study was to evaluate the incidence and risk factors of brucellosis in Kermanshah province during a recent five-year period. Read More

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http://dx.doi.org/10.2174/1871526519666181211155420DOI Listing
December 2018
2 Reads

Target discovery for new antitubercular drugs using a large dataset of growth inhibitors from PubChem.

Authors:
Robert C Goldman

Infect Disord Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Drug Discovery and Development, RCG Consulting, 16024 Golden Lakes Drive. United States.

The number of drugs available for treatment of active tuberculosis are diminishing due to increased multidrug resistance selection in Mycobacterium tuberculosis leading to multiple (MDR) and extensively (XDR) resistant strains. Also, TB is treated with multiple drugs to minimize further resistance development, mandating a sustained effort to identify new lead compounds for treating drug resistant TB, and shortening time to cure for all TB infections. High throughput screening, a well-known approach to discovery of new leads, is conducted in two basic modes 1) using whole cells and screening for inhibition of growth, or whole cell reporter cells that signals when a specific pathway is perturbed, and 2) in vitro non-cell based enzyme or other functional assays for direct ligand-target binding. Read More

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http://dx.doi.org/10.2174/1871526519666181205163810DOI Listing
December 2018
2 Reads

Molecular Modeling Studies of Halogenated Imidazoles against 14α-Demethylase from Candida albicans for treating Fungal Infections.

Infect Disord Drug Targets 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology, Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana-133203, Haryana. India.

Imidazole is one of the most explored and marketed azole utilized for the treatment of fungal infections. Lanosterol 14α-demethylase (Cytochrome P450DM) is the active target site for azole antifungals. This study emphasized on evaluation of a series of halogenated imidazole analogues using molecular docking studies for anti-Candidal activity. Read More

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http://www.eurekaselect.com/167921/article
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http://dx.doi.org/10.2174/1871526519666181130101054DOI Listing
November 2018
2 Reads

High-level aminoglycoside resistance in Enterococcus faecalis and Enterococcus faecium; as a serious threat in hospitals.

Infect Disord Drug Targets 2018 Nov 29. Epub 2018 Nov 29.

Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol. Iran.

The present work aimed to evaluate the frequency of aminoglycoside-modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. Read More

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http://dx.doi.org/10.2174/1871526519666181130095954DOI Listing
November 2018
1 Read

Evaluation of salivary Lipid peroxidation as a possible cause of dental caries.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Research Center for Molecular Medicine, Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan. Iran.

Background: Tissue destruction can be measured by the level of lipid peroxidation (LP) end products. Since free radicals are very reactive with low survival time, the level of free radicals and oxidative stress activity are measured indirectly by tissue damage end product assessment, i.e. Read More

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http://dx.doi.org/10.2174/1871526519666181123182120DOI Listing
November 2018

Repurposing of existing drugs for the bacterial infections: An In silico and In vitro study.

Infect Disord Drug Targets 2018 Nov 25. Epub 2018 Nov 25.

Department of Pharmacology, ISF College of Pharmacy (ISFCP), Moga, Punjab. India.

Background: The emergence of infectious diseases and its resistance to approved drugs is a global threat to human health. The incidence of infectious diseases is increasing day by day and expected to rise exponentially in next 2 decades. Thus, there is a need for new treatment modalities for the treatment of microbial infections. Read More

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http://www.eurekaselect.com/167716/article
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http://dx.doi.org/10.2174/1871526519666181126094244DOI Listing
November 2018
17 Reads

The prevalence of bacteriospermia in infertile men and association with semen quality in Southwestern Iran.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz. Iran.

Introduction: Infertility considered as a social and public health issue and estimated that the most of these infertile couple are residents of developing countries. Infectious diseases including the history of sexually transmitted infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Read More

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http://dx.doi.org/10.2174/1871526519666181123182116DOI Listing
November 2018
10 Reads

Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets

Infect Disord Drug Targets 2018 11 23. Epub 2018 Nov 23.

Department of Life and Environmental Sciences, University of Cagliari, Italy

Upon viral infection, the interferon (IFN) system triggers potent antiviral mechanisms limiting viral growth and spread. Hence, to sustain their infection, viruses evolved efficient counteracting strategies to evade IFN control. Ebola virus (EBOV), member of the family Filoviridae, is one of the most virulent and deadly pathogen ever faced by humans. Read More

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http://dx.doi.org/10.2174/1871526519666181123145540DOI Listing
November 2018
9 Reads

The causative organisms of bacterial meningitis and their antimicrobial resistance profiles in Iranian children in 2011-2016.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran. Iran.

Objectives: To describe the identity and antimicrobial resistance patterns of the causative agents of bacterial meningitis in children referred to Children's Medical Center (CMC) Hospital, Tehran, Iran.

Methods: This retrospective study was performed at CMC Hospital during a six year period from 2011 to 2016. The microbiological information of the patients with a diagnosis of bacterial meningitis was collected and the following data were obtained: patients' age, sex, hospital ward, the results of CSF and blood cultures, and the antibiotic susceptibility profiles of isolated organisms. Read More

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http://dx.doi.org/10.2174/1871526519666181123130101DOI Listing
November 2018
10 Reads

Withdrawn: Controlling HCV infection by targeting its translation initiation site in PBMCs using siRNA; In Vitro.

Authors:

Infect Disord Drug Targets 2018 11 14. Epub 2018 Nov 14.

The manuscript has been withdrawn by the publisher. Read More

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http://www.eurekaselect.com/167381/article
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November 2018
10 Reads

Evaluating the Effect of Cinnarizine on Promastigotes and Amastigotesforms of Leishmania major

Infect Disord Drug Targets 2018 11 12. Epub 2018 Nov 12.

Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious , Diseases, Iran University of Medical Sciences, Tehran, Iran

As an important global disease, cutaneous leishmaniasis is associated with complications such as secondary infections and atrophic scars. The first line treatment with antimonials is expensive and reported to have serious side effects and enhance resistance development. The main objective of this study was to evaluate the effect of Cinnarizine on standard strains of Leishmania major because of paucity of information on this subject. Read More

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http://dx.doi.org/10.2174/1871526518666181113114820DOI Listing
November 2018
19 Reads

Molecular analysis of uropathogenic E.coli isolates from Urinary tract infections in Ilam.

Infect Disord Drug Targets 2018 Nov 12. Epub 2018 Nov 12.

Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam. Iran.

The aim of the current study was to investigate the prevalence virulence genes profile in UPEC isolates in Ilam. For this purpose, a total of 8o UPEC isolates for patients with UTIs were collected during 6 months period. The multiplex polymerase chain reaction (Multiplex PCR) was used for detection of the papEF, fimH, iucD, hlyA, fyuA, and ompT genes. Read More

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http://dx.doi.org/10.2174/1871526518666181113091322DOI Listing
November 2018

Spontaneous chest abscess caused by Salmonella enterica subspp. arizonae; a rare cause of skin and soft tissue infection in the Desert Southwest. Case report and review of the literature.

Infect Disord Drug Targets 2018 Nov 4. Epub 2018 Nov 4.

Texas Tech University Health Sciences Center and Center for Infectious Diseases and Travel Medicine+, New Mexico State University. United States.

Salmonella enterica subspecies arizonae is a rare pathogen but has been reported in the literature in immunosuppressed and rarely immunocompetent patients. Most disease states have been reported in animals and reptiles. Human exposure has resulted in a range of complications from skin and soft tissue infections to bacteremia and periprosthetic joint infections. Read More

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http://dx.doi.org/10.2174/1871526518666181105115226DOI Listing
November 2018
9 Reads

Symptoms of toxicity and plasma cytochrome c levels in human immunodeficiency virus-infected patients receiving anti-retroviral therapy in Ghana: A cross-sectional study.

Infect Disord Drug Targets 2018 Nov 2. Epub 2018 Nov 2.

Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Legon. Ghana.

Background: Side effects and toxicity have posed a threat to the positive contribution of antiretroviral therapy (ART) in the management of human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). Symptoms of mitochondrial toxicity including myopathy, pancreatitis, hyperlipidaemia and lactic acidosis are found among HIV-infected patients on ART. To date, there is not a reliable biomarker for monitoring ART-related mitochondrial toxicity. Read More

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http://dx.doi.org/10.2174/1871526518666181102112010DOI Listing
November 2018
4 Reads

Immunisation status of children with cerebral palsy in rural Bangladesh: results from the Bangladesh Cerebral Palsy Register (BCPR).

Infect Disord Drug Targets 2018 Oct 23. Epub 2018 Oct 23.

Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney. Australia.

Background: Cerebral palsy (CP) is the most common cause of physical disability in childhood, with an estimated 17 million cases worldwide. There is limited data concerning the general health of this population and the immunisation status of children with CP is largely unknown.

Objective: We aimed to assess the immunisation status of children with CP in rural Bangladesh and determine the predictors of non-immunisation. Read More

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http://dx.doi.org/10.2174/1871526518666181024101002DOI Listing
October 2018
6 Reads

Defining 'satisfactory response' to therapy in abdominal tuberculosis : A work in progress.

Infect Disord Drug Targets 2018 Oct 22. Epub 2018 Oct 22.

Department of Gastroenterology and General Surgery, Postgraduate Institute of Medical education and Research, Chandigarh. India.

Abdominal tuberculosis is difficult to diagnose due to low sensitivity of microbiological tests and the low histological yield. Satisfactory response to therapy has long been used a criteria for the diagnosis of abdominal tuberculosis. However, the appropriate definitions of response to therapy in abdominal tuberculosis have remained unclear. Read More

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http://dx.doi.org/10.2174/1871526518666181022111323DOI Listing
October 2018
11 Reads

Parasitic Infections in Children with Disability in Resource Poor Settings: the Research Gaps

Infect Disord Drug Targets 2018 10 21. Epub 2018 Oct 21.

Westmead Institute for Medical Research, Marie Bashir Institute, Westmead Hospital. Australia.

The burden of parasitic infections among children with disability in resource poor settings has not been summarised through a focused review. Here, we have summarised the key studies reporting the burden of parasitic infections among children without and with disability. In most instances, among children without disability giardia or soil-transmitted helminths dominate the epidemiology, while among disabled individuals enteric protozoa are the predominant parasites to be reported in both resource-rich and resource-poor countries. Read More

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http://www.eurekaselect.com/166484/article
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http://dx.doi.org/10.2174/1871526518666181022103750DOI Listing
October 2018
6 Reads

Integrated Chemoinformatics-Molecular Docking Approach to Drug Discovery Against Viruses.

Infect Disord Drug Targets 2018 Oct 19. Epub 2018 Oct 19.

Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nazarbayev University, Astana. Kazakhstan.

Background: In the current study, we have used an integrated in silico approach that combines chemoinformatics and molecular docking to screen and test potential therapeutic compounds against viruses in a computer-simulated environment. Fluoroquinolones have been shown to inhibit HCV replication by targeting the helicase activity of HCV NS3. Based on this observation, we hypothesized that natural analogs of fluoroquinolones will have similar or superior inhibitory potential, while having potentially fewer adverse effects. Read More

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http://www.eurekaselect.com/166477/article
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http://dx.doi.org/10.2174/1871526518666181019162359DOI Listing
October 2018
6 Reads

Exploring and prioritization of mobile-based self-management strategies for HIV care.

Infect Disord Drug Targets 2018 Oct 22. Epub 2018 Oct 22.

Department of Health Information Management, Tehran University of Medical Sciences, Tehran. Iran.

Objectives: Appropriate mobile-based self-management strategies can be as new approaches to decelerate the HIV infection progression and improve quality of life. This study aims at (i) identifying in the literature mobile-based self-management strategies for HIV care and (ii) prioritizing those from the point of view of infectious diseases specialists. This study provides some clues to design useful mobile-based self-management tools for HIV patients, from the point of view of practitioners. Read More

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http://dx.doi.org/10.2174/1871526518666181022113900DOI Listing
October 2018

Burkholderia cepacia Complex Causing Pneumonia in an Immunocompetent Non-Cystic Fibrosis Patient: Case Report and Review of Literature.

Infect Disord Drug Targets 2018 Oct 22. Epub 2018 Oct 22.

Department of Microbiology, Government Medical College and Hospital, Sector-32, Chandigarh. India.

Background: Burkholderia cepacia complex is widespread in the environment and has been recognized as a cause of opportunistic pulmonary infections, particularly in patients with cystic fibrosis (CF). The natural ecology of the bacteria as part of plant growth-promoting rhizosphere provides stark contrast to its infectious potential. Its preponderance as a nosocomial pathogen may be due to its ability to survive in antiseptic solutions, contaminate equipments, and intrinsic antimicrobial resistance. Read More

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http://dx.doi.org/10.2174/1871526518666181022112857DOI Listing
October 2018
2 Reads

Anti-Pathogenic Efficacy and Molecular Targets of a Polyherbal Wound Care Formulation (Herboheal) Against Staphylococcus Aureus

Infect Disord Drug Targets 2018 10 22. Epub 2018 Oct 22.

Institute of Science, Nirma University, Ahmedabad- 382481, Gujarat. India.

Background: A polyherbal formulation (Herboheal) traditionally indicated for woundcare was investigated for its anti-virulence potential against the notorious pathogen Staphylococcus aureus. und infections.

Objective: This study aimed at evaluating anti-virulence potential of Herboheal formulation against S. Read More

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http://dx.doi.org/10.2174/1871526518666181022112552DOI Listing
October 2018
11 Reads

Human Fasciolosis in Iran: a meta-analysis study.

Infect Disord Drug Targets 2018 Oct 17. Epub 2018 Oct 17.

Department of Parasitology and Mycology, School of Medicine, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad. Iran.

Background: Fascioliasis, an infectious disorder with a serious public health burden, is caused by two liver flukes belonging to the genus Fasciola. Iran is among the endemic areas for this disease. This study aimed to determine the seroprevalence of Human Fasciolosis in Iran. Read More

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http://dx.doi.org/10.2174/1871526518666181017115028DOI Listing
October 2018
3 Reads

Reuse of biopsy forceps may be associated with risk of transmission of HCV in Egyptian patients undergoing gastrointestinal endoscopy.

Infect Disord Drug Targets 2018 Oct 15. Epub 2018 Oct 15.

Tropical Medicine & Infectious Diseases and internal medicine departments, Tanta University Faculty of Medicine, Tanta. Egypt.

Background And Aims: Hepatitis viruses are not transmitted via gastrointestinal endoscopy except if there are any mistakes in sterilization and disinfection of the endoscope that disrupt the infection control measures. So we aimed to measure the risk of transmitting HCV by GI endoscopy at department of Tropical Medicine and infectious Diseases, in a major University hospital in Egypt.

Methodology: Our study was conducted on four hundred patients with exclusion of those with HCV, HBV, and/or HIV positive antibodies. Read More

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http://dx.doi.org/10.2174/1871526518666181015164002DOI Listing
October 2018
8 Reads

3D QSAR, Docking, Molecular dynamics simulations and MM-GBSA studies of Extended Side Chain of the Antitubercular Drug (6S) 2-Nitro-6-{[4-(trifluoromethoxy) benzyl] oxy}-6,7-dihydro-5H-imidazo[2,1-b] [1,3] oxazine.

Infect Disord Drug Targets 2018 Oct 15. Epub 2018 Oct 15.

Institute of Chemical Technology - Department of Pharmaceutical Sciences and Technology MUMBAI, Maharashtra. India.

PA-824 analogues have been proposed on a promising approach for treating MDR/XDR tuberculosis. In order to understand the structural requirement of reported extended side chain analogues were studied to get insight into their structural requirements responsible for high affinity as a ligand-based pharmacophore, 3D-QSAR model have been developed. A structurally diverse set of 84 molecules was divided into 17 molecules of test set and rest of the 67 molecules of training set. Read More

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http://dx.doi.org/10.2174/1871526518666181015145545DOI Listing
October 2018

Pharmaco-Audiology Vigilance In The Treatment Of Adult Patients With Hiv/Aids: Ototoxicity Monitoring Protocol Recommendation.

Infect Disord Drug Targets 2018 Oct 15. Epub 2018 Oct 15.

Department of Speech Pathology and Audiology, School of Human and Community Development, University of the Witwatersrand, Johannesburg. South Africa.

South Africa is considered the epicenter of HIV/AIDS with a high rate of TB infection as well. Links have been established between treatments of these conditions to ototoxicity. However, no standardized and systematic ototoxicity monitoring exists within the clinical sites where these conditions are treated; with very minimal and adhoc involvement of audiologists as part of the treatment team. Read More

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http://www.eurekaselect.com/166284/article
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http://dx.doi.org/10.2174/1871526518666181016102102DOI Listing
October 2018
1 Read

Prevalence of Metallo-β-Lactamases in Acinetobacter baumannii in Iran: A Review and ‎Meta-Analysis.

Infect Disord Drug Targets 2018 Oct 15. Epub 2018 Oct 15.

Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj. Iran.

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen that causes major public health concerns, especially in hospitalized patients due to acquisition of resistant genes. The aim of this study was to systematically review the published data on the prevalence and dispersion of metallo-β-lactamases (MBLs) genes in A. Read More

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http://dx.doi.org/10.2174/1871526518666181016101430DOI Listing
October 2018

Significant induction of soluble TNFR2 compared with TNFR1 in serum samples of HIV patients with or without antiretroviral medication

Infect Disord Drug Targets 2018 10 16. Epub 2018 Oct 16.

Virology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.

Background Tumor necrosis factor and its receptors (sTNFR1 and sTNFR2) have been implicated in many infectious diseases. Identification of the key receptor (sTNFR1 or sTNFR2) which drives the immunopathogenesis of HIV infection is crucial in developing adjunctive therapy for HIV. Objective This study determined the expression levels of sTNFR1 and sTNFR2 in antiretroviral therapy (ART) - experienced and naïve HIV patients. Read More

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http://dx.doi.org/10.2174/1871526518666181016110409DOI Listing
October 2018
7 Reads

Distribution and characteristics of intrathoracic lymphadenopathy in TB/HIV coinfection.

Infect Disord Drug Targets 2018 Oct 16. Epub 2018 Oct 16.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Background Intrathoracic lymphadenopathy (ITLN) in human immunodeficiency virus (HIV) infected patients may have various etiologies and prognoses. Etiologies of ITLN can be distinguished based on the distribution of enlarged lymph nodes. Sometimes tuberculosis (TB) is the first sign of underlying HIV infection. Read More

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http://dx.doi.org/10.2174/1871526518666181016111142DOI Listing
October 2018
7 Reads

The resistance rate of helicobacter pylori to clarithromycin and main mutations on bacterial genomic responsible for bacterial resistance : A comparative study in children and adults ;Tehran ,Iran.

Infect Disord Drug Targets 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Infectious Disease, Iran University of Medical Sciences ,Tehran. Iran.

Background: High resistance to common antibiotics has become a huge global dilemma in eradicating Helicobacter Pylori infection in both children and adults. The great concern is about the resistance to different classes of antibiotics especially Clarithromycin because of its widespread use. The present survey aimed to assess the resistance rate to Clarithromycin in Helicobacter Pylori isolated in patients aged less than 15 years as compared to patients older than 15 years of age. Read More

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http://dx.doi.org/10.2174/1871526518666181012113052DOI Listing
October 2018

Surreptitious TB infections with recently identified DM people: A cross-sectional study.

Infect Disord Drug Targets 2018 Oct 11. Epub 2018 Oct 11.

Department of Microbiology, Sri Shivani College of Pharmacy, Warangal. India.

Background: Tuberculosis (TB) among Diabetic Mellitus (DM) population is more expected to fail treatment of TB due to smear negative TB.

Objective: We sought to compare and evaluate different methods to study the frequency of TB infections among DM patients.

Method: Sputum and urine samples were collected from 500 newly identified diabetic patients from different diabetic clinics of Warangal districts. Read More

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http://dx.doi.org/10.2174/1871526518666181011152914DOI Listing
October 2018
13 Reads

Diphtheria immunity in Australia: should we be concerned?

Infect Disord Drug Targets 2018 Oct 11. Epub 2018 Oct 11.

National Centre for Immunisation Research & Surveillance (NCIRS), The Children's Hospital at Westmead. Australia.

We report the results of the 2007 national serological survey of immunity to diphtheria in Australia to assess the impact of recent schedule changes on diphtheria immunity, and the adequacy of current policy in the context of increased international travel of people and pathogens. Residual sera (n =1656) collected opportunistically from Australian laboratories in 2007 were tested for diphtheria antibody levels using an enzyme immunoassay, with the protective threshold defined as ≥0.1 IU/mL. Read More

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http://dx.doi.org/10.2174/1871526518666181011114834DOI Listing
October 2018
9 Reads