503 results match your criteria Infectious Agents and Cancer [Journal]


High-risk type human papillomavirus infection and p16 expression in laryngeal cancer.

Infect Agent Cancer 2019 5;14. Epub 2019 Mar 5.

1Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215 Japan.

Background: Oropharyngeal cancers associated with high-risk type human papillomavirus (HR-HPV) infection have better prognosis than virus negative cancers. Similarly, the HPV status in laryngeal cancer (LC) may be associated with better outcome.

Methods: Samples from 88 patients with LC were investigated using the polymerase chain reaction (PCR) and p16 immunohistochemistry for HR-HPV analysis. Read More

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http://dx.doi.org/10.1186/s13027-019-0224-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402092PMC
March 2019
1 Read
2.071 Impact Factor

The prevalence of EBV and CMV DNA in epithelial ovarian cancer.

Infect Agent Cancer 2019 26;14. Epub 2019 Feb 26.

1Department of Gynecology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Background: The underlying cause of epithelial ovarian cancer (EOC) is unknown. It has been theorized that infectious agents could contribute to ovarian tumorigenesis.

Objective: To investigate the potential role of oncogenic viral infection in EOC, we examined the prevalence of Epstein-Barr Virus (EBV) DNA and cytomegalovirus (CMV) DNA in EOC tissue samples. Read More

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http://dx.doi.org/10.1186/s13027-019-0223-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390605PMC
February 2019
2 Reads

Perspectives on immunotherapy via oncolytic viruses.

Infect Agent Cancer 2019 11;14. Epub 2019 Feb 11.

Department of Molecular Medicine, University of Padua, Via A. Gabelli, 63, 35121 Padua, Italy.

Background: With few exceptions, current chemotherapy and radiotherapy protocols only obtain a slightly prolonged survival with severe adverse effects in patients with advanced solid tumors. In particular, most solid malignancies not amenable to radical surgery still carry a dismal prognosis, which unfortunately is also the case for relapsing disease after surgery. Even though targeted therapies obtained good results, clinical experience showed that tumors eventually develop resistance. Read More

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http://dx.doi.org/10.1186/s13027-018-0218-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371415PMC
February 2019
1 Read

Association of host immunity with infection in recurrent gastric cancer.

Infect Agent Cancer 2019 11;14. Epub 2019 Feb 11.

2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background: infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. Read More

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http://dx.doi.org/10.1186/s13027-019-0221-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371572PMC
February 2019

The role of and in pathogenesis of esophageal cancer.

Infect Agent Cancer 2019 30;14. Epub 2019 Jan 30.

1Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

and are anaerobic Gram-negative bacterial species which have been implicated in periodontal diseases as a part of red complex of periodontal pathogens. Esophageal cancer is the eight most common cause of cancer deaths worldwide. Higher rates of esophageal cancer cases may be attributed to lifestyle factors such as: diet, obesity, alcohol and tobacco use. Read More

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http://dx.doi.org/10.1186/s13027-019-0220-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352356PMC
January 2019
1 Read

Effect of hepatitis B virus DNA replication level and anti-HBV therapy on microvascular invasion of hepatocellular carcinoma.

Infect Agent Cancer 2019 21;14. Epub 2019 Jan 21.

1Department of Hepatobiliary and Pancreatic Surgery, the Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao City, 266003 Shandong Province China.

Background: Chronic hepatitis B virus (HBV) infection is a major risk factor for the occurrence and development of cirrhosis and hepatocellular carcinoma (HCC). Microvascular invasion (MVI) of HCC is closely related to postoperative recurrence. We aimed to investigate the effect of HBV DNA replication levels and anti-HBV treatment on the occurrence of MVI in HCC. Read More

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http://dx.doi.org/10.1186/s13027-019-0219-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341680PMC
January 2019
2 Reads

Correction to: Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population.

Infect Agent Cancer 2019 21;14. Epub 2019 Jan 21.

1International Centre for Reproductive health, Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185 P3, 9000 Ghent, Belgium.

[This corrects the article DOI: 10.1186/s13027-016-0114-5.]. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0209-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341690PMC
January 2019
7 Reads

mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome.

Infect Agent Cancer 2018 29;13:43. Epub 2018 Dec 29.

1Molecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP CEP 14784 400 Brazil.

Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood.

Objective: We analyzed hotspot gene mutations in a series of esophageal squamous cell carcinomas associated or not with chagasic megaesophagus, as well as, in chagasic megaesophagus biopsies. We also checked for correlations between the presence of mutations with patients' clinical and pathological features. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0216-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311070PMC
December 2018
18 Reads

Association of HLA-G 3' UTR polymorphism and expression with the progression of cervical lesions in human papillomavirus 18 infections.

Infect Agent Cancer 2018 29;13:42. Epub 2018 Dec 29.

1Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China.

Background: Human leukocyte antigen (HLA)-G is an immune checkpoint molecule, which expression in cervical cancer cells enables them to escape immunosurveillance. To date, limited information has been published on the association of HLA-G genetic background in malignant cells with levels of HLA-G expression and the clinical outcome of patients.

Methods: We investigated the influence of the HLA-G (rs66554220) and + 3142 (rs1063320) polymorphisms in 130 cases of HPV16 infection, 130 cases of HPV18 infection and 185 age-matched, unrelated, HPV-negative, and cytologically normal Chinese Han women. Read More

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http://dx.doi.org/10.1186/s13027-018-0217-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311041PMC
December 2018
7 Reads

Risk factors for liver Cancer in HIV endemic areas of Western Kenya.

Infect Agent Cancer 2018 22;13:41. Epub 2018 Dec 22.

1Jaramogi Oginga Odinga University of Science and Technology, P.O., Box, 210-40601, Bondo,, Kenya.

Background: Hepatocellular carcinoma (HCC) is a malignant cancer of the liver and a leading cause of cancer-related mortality worldwide. Human immunodeficiency virus (HIV) has not been known to have a direct causal relationship with HCC despite independently causing inflammation of the liver. However, little is known on risk factors for HCC patients in an HIV endemic area. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0214-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303973PMC
December 2018
19 Reads

Concurrent and reactivation of hepatitis B virus infection in diffuse large B-cell lymphoma: risk factors and survival outcome.

Infect Agent Cancer 2018 12;13:40. Epub 2018 Dec 12.

Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000 China.

Objective: To determine the clinical features and survival difference of HBV related and Non-HBV related diffuse large B-cell lymphoma (DLBCL) and to evaluate the occurrence of HBV reactivation in DLBCL patients and related risk factors for HBV reactivation after R-CHOP therapy.

Methods: A total of 246 patients diagnosed with CD20+ DLBCL were enrolled from June 2010 to June 2015. The medical records and survival data were analysed. Read More

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http://dx.doi.org/10.1186/s13027-018-0215-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292058PMC
December 2018
1 Read

Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience.

Infect Agent Cancer 2018 11;13:39. Epub 2018 Dec 11.

1Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, 2 Alameda San Marcos Avenue, Chorrillos, 15067 Lima, Peru.

Non-Hodgkin Lymphoma (NHL) is a neoplasm associated with a group of malignancies called AIDs-Defining Malignancies (ADMs) in Human-Immunodeficiency Virus (HIV) -patients. Similar to the case of NHL in Latin America, particularly in Peru, the amount of research done on others ADMs is limited, especially in the case of Kaposi's Sarcoma (KS). Prior investigations have talked about the great potential risk that represents this illness in latin american population, but topics as prognosis factors are yet to be well defined. Read More

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http://dx.doi.org/10.1186/s13027-018-0213-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288895PMC
December 2018
3 Reads

Prognostic role of HPV infection in esophageal squamous cell carcinoma.

Infect Agent Cancer 2018 29;13:38. Epub 2018 Nov 29.

1Department of Surgery, Medical School, University of Pécs, Hungary, Ifjuság Street 13, Pécs, 7624 Hungary.

Background: The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response.

Methods: Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. Read More

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http://dx.doi.org/10.1186/s13027-018-0210-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264038PMC
November 2018
5 Reads

Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer.

Infect Agent Cancer 2018 26;13:37. Epub 2018 Nov 26.

Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.

Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Read More

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http://dx.doi.org/10.1186/s13027-018-0211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260560PMC
November 2018
3 Reads

Mitofusin-2 acts as biomarker for predicting poor prognosis in hepatitis B virus related hepatocellular carcinoma.

Infect Agent Cancer 2018 26;13:36. Epub 2018 Nov 26.

1Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000 People's Republic of China.

Objective: To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC.

Methods: A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis. The relationship between MFN2 expression and clinical features of patients with HCC was analyzed. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0212-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258311PMC
November 2018
13 Reads

Human papilloma virus E1-specific T cell immune response is associated with the prognosis of cervical cancer patients with squamous cell carcinoma.

Infect Agent Cancer 2018 16;13:35. Epub 2018 Nov 16.

1Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi, China.

Background: Cervical cancer is attributable to human papilloma virus (HPV) infection in the majority cases. E1, an HPV derived-protein, plays an important role in the initiation and development of cervical cancer. Our study aims to investigate the HPV E1-specific T cell response in patients with cervical squamous cell carcinoma (CSCC). Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0206-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240195PMC
November 2018
12 Reads

The influence of prostatic infection on serum levels of IL6 and CXCL8 in prostate cancer patients.

Infect Agent Cancer 2018 14;13:34. Epub 2018 Nov 14.

1Department of Urology, Faculty of Medicine and Health, Örebro University, 701 85 Örebro, Sweden.

Background: Chronic prostatic inflammation, caused by has been proposed to influence the risk of prostate cancer development. In vitro studies have demonstrated the capacity of to induce secretion of Interleukin 6 (IL6) and C-X-C motif chemokine ligand 8 (CXCL8) by prostate epithelial cells. Both these inflammatory mediators have been implicated in prostate cancer pathophysiology. Read More

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http://dx.doi.org/10.1186/s13027-018-0204-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234669PMC
November 2018
1 Read

Endemic Kaposi sarcoma in HIV-negative children and adolescents: an evaluation of overlapping and distinct clinical features in comparison with HIV-related disease.

Infect Agent Cancer 2018 9;13:33. Epub 2018 Nov 9.

Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.

Background: Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences between endemic HIV-negative and epidemic HIV-positive pediatric KS in a KS-associated herpesvirus-endemic region of Africa.

Methods: We describe clinical characteristics of 20 HIV-negative children with endemic KS over a six-year period and compare findings with a historical control-an HIV-related pediatric KS cohort from Lilongwe, Malawi. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0207-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230225PMC
November 2018
16 Reads
2.071 Impact Factor

Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx.

Infect Agent Cancer 2018 9;13:32. Epub 2018 Nov 9.

3Laboratory of Medical Microbiology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Background: Oral and oropharyngeal squamous cell carcinomas (OSCC and OPSCC) represent the majority of head and neck squamous cell carcinomas (HNSCC). Human papillomavirus (HPV) is an important etiologic factor together with Epstein-Barr virus (EBV). Little is known on the prevalence of major herpesviruses [EBV, cytomegalovirus (CMV) and HHV-6, - 7 and - 8] in HNSCCs. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0205-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230228PMC
November 2018
20 Reads

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis.

Infect Agent Cancer 2018 9;13:31. Epub 2018 Nov 9.

1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play important roles in cancer progression and maintenance. However, the high risk HPV E5 protein is also demonstrated to affect some cellular pathway and signaling in human cell lines. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0208-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230221PMC
November 2018
11 Reads

Tenofovir disoproxil fumarate reduce incidence of HCC development in CHB-patients with compensated cirrhosis.

Infect Agent Cancer 2018 29;13:30. Epub 2018 Aug 29.

Clinical laboratory, the sixth people's hospital of Qingdao, Qingdao, 266000 Shandong China.

Background: The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analogue regimen or not have a different prognosis.

Methods: Two hundred forty-two CHB-related compensated cirrhosis patients were attributed into groups regarding their anti-virus regimens containing tenofovir disoproxil fumarate (TDF) or not. Read More

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http://dx.doi.org/10.1186/s13027-018-0203-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114711PMC
August 2018
24 Reads

Reducing incidence of cervical cancer: knowledge and attitudes of caregivers in Nigerian city to human papilloma virus vaccination.

Infect Agent Cancer 2018 17;13:29. Epub 2018 Aug 17.

College of Medicine, Enugu State Teaching Hospital Parklane, Enugu, Nigeria.

Background: Despite the high prevalences of Human Papilloma Virus (HPV) infections and cervical cancer in Nigeria, utilization of the HPV vaccine as a highly effective preventive measure remains low. The aim of this study was to find out the awareness and attitudes of caregivers to HPV infections and the factors that determine acceptance of an HPV vaccine for their pre-adolescent girls.

Methods: This was a cross-sectional descriptive study of 508 caregivers of female children in Enugu Nigeria. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0202-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098589PMC
August 2018
17 Reads
2.071 Impact Factor

HPV genotype distribution among women with normal and abnormal cervical cytology presenting in a tertiary gynecology referral Clinic in Ethiopia.

Infect Agent Cancer 2018 14;13:28. Epub 2018 Aug 14.

The AIDS Center, Hadassah University Hospital - Hebrew University, Jerusalem, Israel.

Background: Cervical cancer is the second most prevalent cancer among women of child-bearing age in Ethiopia. The aim of this study was to determine human papilloma virus (HPV) genotype distribution among HIV-negative women with normal and abnormal cervical cytology results.

Methods: We investigated a consecutive of 233 HIV-negative women between December 2008 and March 2009 presenting in a Tertiary Gynecology Referral Clinic in Ethiopia. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0201-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092870PMC
August 2018
29 Reads

Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience.

Infect Agent Cancer 2018 31;13:27. Epub 2018 Jul 31.

4Department of Radiation Oncology, Wake Forest Baptist Medical Center, Winston Salem, NC USA.

Background: Non-Hodgkin lymphoma (NHL) is the most common cancer in people with HIV. Although 95% of HIV patients are in developing countries like Peru, the majority of these studies have been conducted in developed countries. In this study we aim to evaluate prognostic factors associated with outcomes in HIV positive patients undergoing systemic therapy for treatment of NHL. Read More

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http://dx.doi.org/10.1186/s13027-018-0200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069811PMC
July 2018
5 Reads

Prevalence of "unclassified" HPV genotypes among women with abnormal cytology.

Infect Agent Cancer 2018 24;13:26. Epub 2018 Jul 24.

Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", via M Semmola, 80131 Naples, Italy.

Background: High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated.

Methods: Liquid-based cytological samples were collected from 337 women referred for colposcopy following an abnormal cytological diagnosis. Read More

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http://dx.doi.org/10.1186/s13027-018-0199-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056927PMC
July 2018
16 Reads

Glycogene expression profiles based on microarray data from cervical carcinoma HeLa cells with partially silenced E6 and E7 HPV oncogenes.

Infect Agent Cancer 2018 20;13:25. Epub 2018 Jul 20.

1Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km. 4.5 Carretera Federal Atlixco-Metepec, Atlixco, C.P. 74360 Puebla, Mexico.

Background: Aberrant glycosylation is a characteristic of tumour cells. The expression of certain glycan structures has been associated with poor prognosis. In cervical carcinoma, changes in the expression levels of some glycogenes have been associated with lymph invasion. Read More

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http://dx.doi.org/10.1186/s13027-018-0197-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053821PMC
July 2018
5 Reads

Prevalence of CagA and antimicrobial sensitivity of isolates of patients with gastric cancer in Egypt.

Infect Agent Cancer 2018 16;13:24. Epub 2018 Jul 16.

2Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: ) infection has been recognized as a significant threat for gastric cancer. However, studies that investigated the oncogenic factors and antimicrobial resistance of in Egyptian isolates with gastric cancer are rare. The current study aimed to examine: (1) The pattern of antimicrobial resistance of isolates of Egyptian gastric cancer patients, and (2) the prevalence of Cytotoxin-associated gene A (CagA). Read More

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http://dx.doi.org/10.1186/s13027-018-0198-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048886PMC
July 2018
20 Reads
2.071 Impact Factor

The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC.

Infect Agent Cancer 2018 3;13:23. Epub 2018 Jul 3.

1Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - IRCCS di Napoli, via Mariano Semmola, I-80131 Naples, Italy.

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Read More

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http://dx.doi.org/10.1186/s13027-018-0194-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029348PMC
July 2018
3 Reads

Plasmablastic lymphoma in Malawi.

Infect Agent Cancer 2018 28;13:22. Epub 2018 Jun 28.

UNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Read More

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http://dx.doi.org/10.1186/s13027-018-0195-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022505PMC
June 2018
12 Reads

Tenofovir decrease hepatocellular carcinoma recurrence in chronic hepatitis B patients after liver resection.

Infect Agent Cancer 2018 8;13:19. Epub 2018 Jun 8.

Invasive Technology Department, Jining NO.1 People's Hospital, Jining, Shandong 272100 People's Republic of China.

Background: Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigate whether CHB-related HCC patients receiving TDF and ETV have a different prognosis. Read More

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http://dx.doi.org/10.1186/s13027-018-0191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994044PMC
June 2018
10 Reads

Negative effect of hepatitis in overall and progression-free survival among patients with diffuse large B-cell lymphoma.

Infect Agent Cancer 2018 7;13:18. Epub 2018 Jun 7.

2College of Medicine (COM), King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia.

Background: Hepatitis B virus (HBV) is one of the most prevalent and serious infections worldwide. HBV reactivation is a serious complication for lymphoma patients who are being treated with rituximab-containing regimen. Since the impact of HBV has not been fully evaluated on the prognosis of diffuse large B cell lymphoma (DLBCL), this study examined the effect of the hepatitis infection on the progression-free survival (PFS) and overall survival (OS) in patients with DLBCL who received rituximab-containing chemotherapy. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0190-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992760PMC
June 2018
14 Reads

Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.

Infect Agent Cancer 2018 11;13:21. Epub 2018 Jun 11.

1Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infection and p16 positive OPSCC is now recognized as a separate disease entity. There are only limited data available regarding HPV-related OPSCC in Asian countries and no data from Malaysia. Read More

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http://dx.doi.org/10.1186/s13027-018-0193-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996537PMC
June 2018
6 Reads

Prognostic factors in patients with HBV-related hepatocellular carcinoma following hepatic resection.

Infect Agent Cancer 2018 8;13:20. Epub 2018 Jun 8.

Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Praram VI Road, Ratchathewi, Bangkok, 10400 Thailand.

Background: To analyze prognostic factors following hepatic resection in patients with HBV-related hepatocellular carcinoma.

Methods: We retrospectively analyzed 217 patients with HBV-related hepatocellular carcinoma who underwent hepatic resection at our hospital between January 2006 and December 2015. Disease-free survival and overall survival rates were analyzed using the Kaplan-Meier method and the log-rank test. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0192-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994073PMC
June 2018
4 Reads

Comparison of anti-HBV regimen with or without adefovir on hepatocellular carcinoma development of Chronic hepatitis B patients with compensated cirrhosis: a retrospective cohort study.

Infect Agent Cancer 2018 22;13:17. Epub 2018 May 22.

3Department of oncology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000 People's Republic of China.

Background: The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analogue regimen or not have a different prognosis.

Methods: 242 CHB-related compensated cirrhosis patients from 2008 June to 2011 December were included in our study and attributed into groups based on their anti-virus regimens containing adefovir (ADV) or not. Read More

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http://dx.doi.org/10.1186/s13027-018-0189-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963167PMC
May 2018
1 Read

Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America.

Infect Agent Cancer 2018 8;13:16. Epub 2018 May 8.

Fundación Huésped, Pasaje Gianantonio 3932, C1202ABB Buenos Aires, Argentina.

Background: This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort.

Methods: Demographic, cancer, and HIV-related data from HIV-positive adults diagnosed with cancer ≤ 1 year before or any time after HIV diagnosis from January 1, 2000-June 30, 2015 were retrospectively collected. Cancer cases were classified as AIDS-defining cancers (ADC) and non-AIDS-defining cancers (NADC). Read More

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http://dx.doi.org/10.1186/s13027-018-0188-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941620PMC
May 2018
27 Reads
2.071 Impact Factor

Epidemiologic and economic burden of HPV diseases in Spain: implication of additional 5 types from the 9-valent vaccine.

Infect Agent Cancer 2018 2;13:15. Epub 2018 May 2.

Health Economics and Outcomes Research, Real World Insights, IQVIA, Barcelona, Spain.

Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women. Read More

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http://dx.doi.org/10.1186/s13027-018-0187-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930836PMC
May 2018
8 Reads

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications.

Infect Agent Cancer 2018 10;13:14. Epub 2018 Apr 10.

1Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padova, Italy.

The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote tumorigenesis, EBV must restrict its lytic cycle, which would ultimately lead to cell death, selectively express latent viral proteins, and establish an unlimited proliferative potential. The latter step depends on the maintenance of telomere length provided by telomerase. Read More

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http://dx.doi.org/10.1186/s13027-018-0186-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892012PMC
April 2018
19 Reads

Human papillomavirus genome variants and head and neck cancers: a perspective.

Infect Agent Cancer 2018 10;13:13. Epub 2018 Apr 10.

2Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Via Franco Gallini 2, 33081 Aviano, PN Italy.

Human papillomaviruses (HPV) cause infections that are responsible for diverse clinical manifestations from benign conditions to invasive cancer. As different HPV types are associated with variable pathogenic potential, minor genetic variations within a given high-risk HPV type might also be associated with distinct oncogenic capacities, through variable ability of persistence or risk of progression to precancer/cancer. Most recent HPV variant studies in the cervix using latest sequencing technology confirmed that minor changes in the HPV genome can have a major influence on carcinogenesis and have revealed key data that help better understand the carcinogenicity of HPV at a molecular level. Read More

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http://dx.doi.org/10.1186/s13027-018-0185-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891965PMC
April 2018
2 Reads

Role of BK human polyomavirus in cancer.

Infect Agent Cancer 2018 5;13:12. Epub 2018 Apr 5.

2Departamento de Oncología Básico clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. Read More

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http://dx.doi.org/10.1186/s13027-018-0182-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887205PMC
April 2018
3 Reads

Immunogenicity of a Fap2 peptide mimotope of and its potential use in the diagnosis of colorectal cancer.

Infect Agent Cancer 2018 2;13:11. Epub 2018 Apr 2.

2Research Center for Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.

Background: The role of Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of natural killer (NK) cells against cancer cells, thus, allowing proliferation of the latter eventually leading to tumor growth. The aim of the study was to identify the immunogenicity of a peptide mimotope of the Fap2 protein and to determine the reactivity of colorectal cancer patients' sera against the mimotope. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s13027-018-0184-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879760PMC
April 2018
8 Reads

Cellular prognostic markers in hepatitis-related hepatocellular carcinoma.

Infect Agent Cancer 2018 27;13:10. Epub 2018 Mar 27.

1Laboratory of Cancer Immunoregulation, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Via Mariano Semmola, 1, 80131 Naples, Italy.

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from cancer in men and women, respectively. HBV and HCV chronic infection is the main risk factor for HCC. Read More

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http://dx.doi.org/10.1186/s13027-018-0183-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870199PMC
March 2018
4 Reads

The role of bacteria in cancer therapy - enemies in the past, but allies at present.

Infect Agent Cancer 2018 15;13. Epub 2018 Mar 15.

1Department of Medical Microbiology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian, 116044 China.

In recent decades, bacteria's therapeutic role has aroused attention in medicinal and pharmaceutical research. While bacteria are considered among the primary agents for causing cancer, recent research has shown intriguing results suggesting that bacteria can be effective agents for cancer treatment - they are the perfect vessels for targeted cancer therapy. Several bacterial strains/species have been discovered to possess inherent oncolytic potentials to invade and colonize solid tumors in vivo. Read More

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http://dx.doi.org/10.1186/s13027-018-0180-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856380PMC
March 2018
6 Reads

Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma.

Infect Agent Cancer 2018 13;13. Epub 2018 Mar 13.

1Department of Cell and Molecular Biology, Team Cytokines and Nitric oxide synthases. Faculty of Biology, University Houari Boumediene USTHB, Bab-Ezzouar, Algiers, Algeria.

Background: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s13027-018-0181-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851087PMC
March 2018
39 Reads

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

Infect Agent Cancer 2018 2;13. Epub 2018 Feb 2.

2Division of Molecular Medicine & Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV infection (OBI). Previous reports showed that HBV variants in OBI-related HCC are different from those in HBsAg-positive HCC. In the present study, HBV quasispecies based on the pre-S/S gene in OBI-related HCC patients were examined by high throughput sequencing and compared with those in HBsAg-positive HCC. Read More

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http://dx.doi.org/10.1186/s13027-018-0179-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797373PMC
February 2018
7 Reads

Prevalence of human papillomavirus infection among Iranian women using COBAS HPV DNA testing.

Infect Agent Cancer 2018 25;13. Epub 2018 Jan 25.

Department of Biostatistics, Faculty of Medical Sciences, TarbiatModares University, Tehran, Iran.

Background: Persistent infection with High Risk Human Papillomavirus (HR HPV) typesplaysamajor role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cancer screening. The aim of this study was to estimate the prevalence of HR HPV infection among healthy women undergoing routine cervical cancer screening in Iran. Read More

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http://dx.doi.org/10.1186/s13027-018-0178-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784531PMC
January 2018
9 Reads

HIV-associated Kaposi's sarcoma in Maputo, Mozambique: outcomes in a specialized treatment center, 2010-2015.

Infect Agent Cancer 2018 19;13. Epub 2018 Jan 19.

5Epicentre, 8 rue Saint-Sabin, 75011 Paris, France.

Background: Kaposi's sarcoma (KS) is a common HIV-associated malignancy associated with disability, pain and poor outcomes. The cornerstone of its treatment is antiretroviral therapy, but advanced disease necessitates the addition of chemotherapy. In high-income settings, this often consists of liposomal anthracyclines, but in Mozambique, the first line includes conventional doxorubicin, bleomycin and vincristine, which is poorly-tolerated. Read More

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http://dx.doi.org/10.1186/s13027-018-0177-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775566PMC
January 2018
36 Reads

Human papillomavirus genotype distribution in cervical cancer biopsies from Nepalese women.

Infect Agent Cancer 2018 17;13. Epub 2018 Jan 17.

2Oncogenic Viruses Laboratory, National Institute of Infectious Diseases-ANLIS "Dr. Malbrán", Av. Velez Sarsfield 563, C1282AFF Buenos Aires, Argentina.

Background: Cervical cancer (CC) is the leading cause of morbidity and mortality from cancer in Nepalese women. Nearly all cases of CC are caused by infection with certain genotypes of human papillomavirus (HPV). Data on HPV genotype distribution in Nepalese CC patients is sparse. Read More

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http://dx.doi.org/10.1186/s13027-018-0176-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773015PMC
January 2018
9 Reads

Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge.

Infect Agent Cancer 2018 15;13. Epub 2018 Jan 15.

1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori - IRCCS - "Fondazione G. Pascale", Via Mariano Semmola, 80131 Naples, Italy.

Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), although it has been reported that also the contaminations of beef infected by oncogenic bovine viruses could increase colorectal cancer's risk. Regarding the mechanisms underlying the potential carcinogenicity of red and processed meat, different hypotheses have been proposed. Read More

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http://dx.doi.org/10.1186/s13027-018-0174-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769331PMC
January 2018
9 Reads

HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan.

Infect Agent Cancer 2018 12;13. Epub 2018 Jan 12.

4Charles University in Prague, University Hospital Motol, Prague, Czech Republic.

Background: Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Read More

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http://dx.doi.org/10.1186/s13027-018-0175-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767046PMC
January 2018
3 Reads

Could subspecies cause Crohn's disease, ulcerative colitis…and colorectal cancer?

Authors:
Ellen S Pierce

Infect Agent Cancer 2018 4;13. Epub 2018 Jan 4.

Spokane Valley, Washington, USA.

Infectious agents are known causes of human cancers. and cause a percentage of colorectal cancers in countries where the respective species are prevalent. Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). Read More

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http://dx.doi.org/10.1186/s13027-017-0172-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753485PMC
January 2018
8 Reads