9,451 results match your criteria Infectious Endocarditis


Role of the Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.

Infect Immun 2021 Jul 6:IAI0034721. Epub 2021 Jul 6.

Department of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.

GraS is a membrane sensor in that induces and expression to alter the surface positive charge upon exposure to cationic human defense peptides (HDPs). The sensing domain of GraS likely resides in the 9-residue extracellular loop (EL). In this study, we assessed a hospital-acquired (HA)-MRSA strain (COL) for the specific role of two distinct EL mutations: F38G (bulk) and D/35/37/41K (charged inversion). Read More

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Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus.

Enferm Infecc Microbiol Clin 2021 Jul 2. Epub 2021 Jul 2.

Infectious Disease Department, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain. Electronic address:

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Basis of the persistence of capsule-negative Streptococcus suis in porcine endocarditis inferred from comparative genomics.

FEMS Microbiol Lett 2021 07;368(13)

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.

The capsule (cap) of Streptococcus suis is an anti-phagocytic element and is one of the major virulence factors. However, we have found cap-positive and cap-negative isolates in porcine endocarditis. Here, we compared genome sequences of multiple cap-negative isolates with those of a cap-positive isolate from a single endocarditis. Read More

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The New Challenge for Heart Endocarditis: From Conventional Prosthesis to New Devices and Platforms for the Treatment of Structural Heart Disease.

Biomed Res Int 2021 14;2021:7302165. Epub 2021 Jun 14.

Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, UK.

Infective endocarditis is a sinister condition with considerable morbidity and mortality. Its relevance in the current era is compounded by the increased use of implanted devices such as replacement valves or cardiac implantable electronic devices. These infections are caused by multiple different bacteria with different virulence, pathogenicity, and antimicrobial resistance. Read More

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Bloodstream Infection Associated with an Urticarial Exanthem.

Case Rep Infect Dis 2021 10;2021:9932170. Epub 2021 Jun 10.

Section of Infectious Diseases, Medical Service, Oklahoma City VA Health Care System, 921 NE 13th Street, Oklahoma City, OK 73104, USA.

. Capnocytophaga canimorsus is a fastidious, slow-growing, Gram-negative rod that is a commensal bacterium in normal gingival flora of canine and feline species. Infection with the organism may cause disease ranging from flu-like symptoms to disseminated intravascular coagulation (DIC), fulminant sepsis, meningitis, and endocarditis with an overall fatality rate of 6-26%. Read More

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endocarditis in an immunocompetent host.

Proc (Bayl Univ Med Cent) 2021 Apr 2;34(4):494-495. Epub 2021 Apr 2.

Department of Infectious Diseases, Baylor Scott and White Medical Center - Round Rock, Round Rock, Texas.

This case describes an 83-year-old immunocompetent woman who presented to the emergency department with complaints of nausea, vomiting, and dizziness. She was found to have evidence of embolic stroke secondary to endocarditis. This case emphasizes the challenge of diagnosing fungal endocarditis, as it can be difficult to culture, and the importance of broad differentials even in patients with no obvious risk factors. Read More

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Pasteurella Cerebral Mycotic Aneurysm: A Case Report and Review of the Literature.

Cureus 2021 May 29;13(5):e15312. Epub 2021 May 29.

Department of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, USA.

species (spp.) are pleomorphic, Gram-negative, facultatively anaerobic bacilli commonly found in the upper respiratory tract and oral cavities of wild and domesticated animals such as dogs and cats. spp. Read More

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Endocarditis in Liver Transplant Recipients: A Systematic Review.

J Clin Med 2021 Jun 16;10(12). Epub 2021 Jun 16.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.

Infective Endocarditis (IE) is associated with significant mortality. Interestingly, IE in patients with liver transplantation has not been adequately described. The aim of this review was to systematically review all published cases of IE in liver transplant recipients and describe their epidemiology, microbiology, clinical characteristics, treatment and outcomes. Read More

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Incidence and Risk Factors for Acute Kidney Injury during the Treatment of Methicillin-Sensitive Infections with Cloxacillin Based Antibiotic Regimens: A French Retrospective Study.

J Clin Med 2021 Jun 12;10(12). Epub 2021 Jun 12.

Department of Infectious Diseases, Le Mans General Hospital, 72000 Le Mans, France.

Background: Cloxacillin has been associated with the occurrence of acute kidney injury (AKI). The incidence of this complication in the literature is low (2.5-3. Read More

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Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome.

Curr Med Mycol 2020 Dec;6(4):70-74

Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background And Purpose: species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%.

Case Report: Herein, we report a four- year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. Read More

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December 2020

Rare presentation of infective endocarditis due to Salmonella entrica subspecies salamae (subgroup ll) in a sickle cell anemia girl.

IDCases 2021 10;25:e01184. Epub 2021 Jun 10.

Pediatric Department, King Fahad Central Hospital, Jazan, Saudi Arabia.

Sickle cell anemia (SCA) is a common inherited kind of hemolytic anemia in Africa and some areas of Asia. In Saudi Arabia, SCA is prevalent as well. The patient of SCA is prone to some bacteria species more than the others, and Salmonella is one of the most prevalent infections in SCA that were known to cause bacteremia, osteomyelitis, septic arthritis, and gastroenteritis. Read More

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Splinter haemorrhages and brain infarcts as an unusual presentation of sarcoidosis.

BMJ Case Rep 2021 Jun 30;14(6). Epub 2021 Jun 30.

Rheumatology Department, Royal Derby Hospital, Derby, UK.

We present an interesting case of a healthy 47-year-old woman who presented to the acute take with symptoms of visual apraxia, splinter haemorrhages and extreme fatigue. This was a diagnostic challenge with other unusual features to this case, which includes brain infarcts on MRI, raised troponin and oeosinophilia. Naturally endocarditis was the top differential but this was ruled out by serial negative blood cultures and a negative transthoracic echocardiogram. Read More

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A Brewing Back Pain.

N Engl J Med 2021 Jul;385(1):66-72

From the Department of Medicine, Section of Infectious Diseases (L.P.), the Division of Cardiac Surgery (A.G.), the Department of Internal Medicine and Pediatrics (R.A.M.), and the Department of Internal Medicine, Section of Hematology (A.I.L.), Yale School of Medicine, the Department of Epidemiology of Microbial Diseases, Yale School of Public Health (L.P.), and the Department of Infection Prevention, Yale New Haven Health (R.A.M.), New Haven, and Hartford Hospital, Hartford (J.M.) - all in Connecticut.

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Diagnostic complexity of rifampicin-induced coagulopathy in a patient with spontaneous muscle bleeding: A case report.

Medicine (Baltimore) 2021 Jul;100(26):e26234

Department for Internal Medicine, General Hospital "dr. Josip Benčević," Andrije Štampara 42, Slavonski Brod, Croatia.

Introduction: Rifampicin is currently used to treat various bacterial infections, with the most significant application in the treatment of tuberculosis. Dose-independent side effects of the drug can lead to the development of various coagulation disorders, among which disseminated intravascular coagulation is the most dangerous. The mechanism of coagulopathy itself is multifactorial, but it is thought to be mediated by an immune response (formation of antigen-antibody complexes) and consequent damage to platelets and the vascular endothelium. Read More

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Clinical Features and Outcomes of Group Infective Endocarditis: A Multicenter Matched Cohort Study.

Open Forum Infect Dis 2021 Jun 29;8(6):ofab163. Epub 2021 Mar 29.

Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut d´Investigació Biomèdica de Bellvitg e, University of Barcelona, Barcelona, Spain.

Background: Although group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption.

Methods: We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or group (SGG) was performed in a 1:2 matched analysis. Read More

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The Dynamics of Infectious Diseases Associated With Injection Drug Use in Lawrence and Lowell, Massachusetts.

Open Forum Infect Dis 2021 Jun 15;8(6):ofab128. Epub 2021 Mar 15.

Department of Biostatistics, Yale School of Public Health, Connecticut, USA.

Background: There are a wide variety of infectious complications of injection drug use. Understanding the trajectory of these complications might inform the development of an early warning system for human immunodeficiency virus (HIV) outbreaks that occur regularly among people who inject drugs (PWID).

Methods: A distributed lag Poisson regression model in the Bayesian setting was used to examine temporal patterns in the incidence of injection-associated infectious diseases and their association with HIV cases in Lawrence and Lowell, Massachusetts between 2005 and 2018. Read More

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Outcomes and Risk Factors of Septic Shock in Patients With Infective Endocarditis: A Prospective Cohort Study.

Open Forum Infect Dis 2021 Jun 25;8(6):ofab119. Epub 2021 Mar 25.

Infectious Diseases Department, Hospital Clinic, Barcelona, Spain.

Background: Little is known about the characteristics and impact of septic shock (SS) on the outcomes of infective endocarditis (IE). We aimed to investigate the characteristics and outcomes of patients with IE presenting with SS and to compare them to those of IE patients with sepsis (Se) and those with neither Se nor SS (no-Se-SS).

Methods: This is a prospective cohort study of 4864 IE patients from 35 Spanish centers (2008 to 2018). Read More

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An unusual case of infective endocarditis with acute limb ischemia and cardiac embolism.

IDCases 2021 17;25:e01201. Epub 2021 Jun 17.

Department of Infectious Disease, Louisiana State University Health Sciences Center, Shreveport, USA.

Infective endocarditis (IE) is a persistent health issue, particularly among intravenous drug users. We discussed a case of infective endocarditis in a patient who uses IV drugs, which had some unusual features such as unusual presentation, polymicrobial infection, left-sided valve involvement, coronary embolism, and an uncommon pathogen for IE. Read More

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Native valve endocarditis and pacemaker infection with Mycobacterium fortuitum.

IDCases 2021 16;25:e01200. Epub 2021 Jun 16.

Department of Infectious Disease, Mercyhealth, Rockford, IL, USA.

Endocarditis and cardiac device infection due to is a rare entity in the hospital settings. We report a case of pacemaker infection and native valve endocarditis due to , which was associated with tricuspid valve vegetation. two days after admission with fever, chills, body aches and swelling around her pacemaker, the patient's pacing system was surgically removed. Read More

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Bacterial infections in people who inject psychoactive substances: An observational study in a French university hospital.

Therapie 2021 Jun 1. Epub 2021 Jun 1.

Regional Addictovigilance Center, Montpellier University Hospital, 34295 Montpellier, France. Electronic address:

Aim Of The Study: To describe bacterial infections in injection drug users (IDUs) hospitalized at Montpellier University Hospital, France, and to identify factors that might influence the development of local or systemic infections.

Methods: This cross-sectional observational monocentric study prospectively included bacterial infections in IDUs hospitalized at Montpellier University Hospital between 2012 and 2018. Types of infection (local or systemic) were described and compared to identify specific features (injection practices). Read More

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Infection Rate and Outcomes of Watchman Devices: Results from a Single-Center 14-Year Experience.

Biomed Hub 2021 May-Aug;6(2):59-62. Epub 2021 Jun 3.

Department of Cardiovascular Disease, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

The Watchman device (WD) is a commonly used alternative strategy to oral anticoagulation for stroke risk reduction in patients with atrial fibrillation who have an increased bleeding risk. There are rare case reports of WD-related infection. Currently, there is no formal study that has systematically evaluated the incidence and outcomes WD-related infections. Read More

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Medically managed prosthetic valve endocarditis caused by .

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Infectious Diseases, Northern Care Alliance NHS Group, Manchester, UK.

Infective endocarditis is associated with morbidity and mortality even when appropriately treated. It can be more complicated to treat when prosthetic material is present, often necessitating surgical revision as well as antimicrobial therapy. Endocarditis caused by gram-negative bacilli is a rare occurrence, with some literature and expert opinion suggesting superior outcomes with combined surgery and antibiotics when a prosthetic valve is involved. Read More

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Case of eustachian valve endocarditis and the importance of synergistic antibiotic therapy.

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Medicine, Division of Infectious Diseases, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

A 46-year-old woman with a history of end-stage renal disease on chronic haemodialysis presented with 1 week of fever, chills, altered mental status and hand pain. She was febrile and ill-appearing on presentation with a pulse rate of 102 beats per minute. She had a tunnelled dialysis catheter in her right neck. Read More

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Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.

Am Heart J 2021 Jun 20;240:63-72. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, North Carolina; Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD.

Background: The epidemiology, and outcome of infective endocarditis (IE) among solid organ transplant (SOT) recipients is unknown.

Methods: We used data from the 2013-2018 Nationwide Readmissions Database (NRD). IE- and SOT-associated hospitalizations were identified using diagnosis and procedure codes. Read More

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Rural-urban differences in hospitalizations for opioid use-associated infective endocarditis in Kentucky, 2016-2019.

J Rural Health 2021 Jun 18. Epub 2021 Jun 18.

Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky.

Purpose: In 2016, the US rate of opioid use-associated infective endocarditis (OUA IE) hospitalizations was 3.86/100,000 for rural and 3.49/100,000 for urban residents. Read More

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Q Fever Endocarditis in Northeast Iran.

Case Rep Infect Dis 2021 28;2021:5519164. Epub 2021 May 28.

Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

This report presents a case of chronic Q fever endocarditis. A 60-year-old male farmer and rancher was admitted to the hospital with symptoms of weight loss, fever, severe sweating, weakness, and anorexia. PCR was negative for in the blood sample, but phase I and II IgG antibodies against were positive (1 : 16384 and 1 : 2048, respectively) by the indirect immunofluorescent assay (IFA). Read More

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Impact of delayed device re-implantation on outcomes of patients with cardiovascular implantable electronic device related infective endocarditis.

Pacing Clin Electrophysiol 2021 Jun 16. Epub 2021 Jun 16.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.

Background: Optimal timing of cardiovascular implantable electronic device (CIED) re-implantation following device removal due to infection is undefined. Multinational guidelines reflect this and include no specific recommendation for this timing, while others have recommended waiting at least 14 days in cases of CIED related infective endocarditis (CIED-IE). The current work seeks to clarify this issue. Read More

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The efficacy and safety of intravenous lincosamide therapy in methicillin-resistant bacteremia.

Antimicrob Agents Chemother 2021 Jun 14:AAC0034321. Epub 2021 Jun 14.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.

Methicillin-resistant (MRSA) bacteraemia has a high case-fatality rate, but currently recommended antimicrobial therapies have many shortcomings. The efficacy and safety of lincosamide therapy for MRSA bacteraemia is incompletely defined. A retrospective audit of the management of all adults with MRSA bacteraemia at an Australian tertiary-referral hospital between 1 January 2007 and 31 December 2020. Read More

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A Report of Candida blankii Fungemia and Possible Endocarditis in an Immunocompetent Individual and the Review of Literature.

Cureus 2021 May 10;13(5):e14945. Epub 2021 May 10.

Division of Infectious Diseases, Veterans Affairs Medical Center, Gainesville, USA.

 is an emerging pathogenic fungus, first identified in 1968 as a new species. In the past five years, it has been identified in cystic fibrosis patient's airways and as fungemia in immunocompromised patients (post lung transplant and preterm neonates). It has been postulated to be a possible opportunistic pathogen based on the published case reports. Read More

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Extensive right-sided infectious endocarditis due to .

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Cardiology, Centro Hospitalar do Médio Ave EPE, Vila Nova de Famalicão, Portugal.

is a rare cause of infectious endocarditis. Most cases have an acute and aggressive evolution, with a high mortality rate. We report the case of a 36-year-old man, with a history of unrepaired ventricular septal defect, who came to the emergency department with fever, cough and asthenia with 3 months of evolution. Read More

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