31,322 results match your criteria Infection and Immunity[Journal]


Lectin activity of the TcdA and TcdB toxins of .

Infect Immun 2018 Dec 10. Epub 2018 Dec 10.

Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.

is a major cause of hospital-acquired antibiotic-associated diarrhoea. produces two cytotoxins, TcdA and TcdB, both toxins are multi-domain proteins that lead to cytotoxicity through the modification and inactivation of small GTPases of the Rho/Rac family. Previous studies have indicated that host glycans are targets for TcdA and TcdB, with interactions thought to be with both α- and β-linked galactose. Read More

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http://dx.doi.org/10.1128/IAI.00676-18DOI Listing
December 2018

A novel, multiple-antigen pneumococcal vaccine protects against lethal challenge.

Infect Immun 2018 Dec 10. Epub 2018 Dec 10.

Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom

Current vaccination against uses vaccines based on capsular polysaccharides from selected serotypes, and has led to non-vaccine serotype replacement disease. We have investigated an alternative serotype-independent approach, using multiple-antigen vaccines (MAV) prepared from TIGR4 lysates enriched for surface proteins by a chromatography step after culture under conditions that induce expression of heat shock proteins (Hsp, thought to be immune adjuvants). Proteomics and immunoblots demonstrated that compared to standard bacterial lysates, MAV was enriched with Hsps and contained several recognised protective protein antigens, including pneumococcal surface protein A (PspA) and pneumolysin (Ply). Read More

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http://dx.doi.org/10.1128/IAI.00846-18DOI Listing
December 2018
4 Reads

The SOS Response Mediates Sustained Colonization of the Mammalian Gut.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Bacteria have a remarkable ability to survive, persist, and ultimately adapt to environmental challenges. A ubiquitous environmental hazard is DNA damage and most bacteria have evolved a network of genes known as the SOS response to combat genotoxic stress. The SOS response aids in bacterial survival by regulating genes involved in DNA repair and damage tolerance. Read More

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http://dx.doi.org/10.1128/IAI.00711-18DOI Listing
December 2018

The impact of co-infection on colonisation of the chicken.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK.

can cause the disease coccidiosis in chickens. The direct and often detrimental impact of this parasite on chicken health, welfare and productivity is well recognised, however less is known about the secondary effects infection may have on other gut pathogens. is the leading cause of human bacterial food-borne disease in many countries and has been demonstrated to exert negative effects on poultry welfare and production in some broiler lines. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00772-18
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http://dx.doi.org/10.1128/IAI.00772-18DOI Listing
December 2018
4 Reads

Methamphetamine impairs IgG1-mediated phagocytosis and killing of by J774.16 macrophage- and NR-9640-microglia-like cells.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY

The prevalence of methamphetamine (METH) use is estimated at ∼35 million people worldwide, with over 10 million users in the United States. Chronic METH abuse and dependence expose the users to participate in risky behaviors that may result in the acquisition of HIV and AIDS-related infections. is an encapsulated fungus that causes cryptococcosis, an opportunistic infection that has recently been associated with drug users. Read More

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http://dx.doi.org/10.1128/IAI.00113-18DOI Listing
December 2018
1 Read

The role of gonococcal Neisserial surface protein A (NspA) in serum resistance and comparison of its factor H binding properties with that of its meningococcal counterpart.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605.

the causative agent of gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement inhibitor factor H (FH). We previously reported FH binding to independently of lipooligosaccharide (LOS) sialylation. Here we report that Factor H-like protein 1 (FHL-1), which contains FH domains 1 through 7 and possesses complement inhibitory activity, also binds to The ligand for both FH and FHL-1 was identified as Neisserial surface protein A (NspA), which has previously been identified as a ligand for these molecules on As with -NspA, NspA bound FH/FHL-1 through FH domains 6 and 7. Read More

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http://dx.doi.org/10.1128/IAI.00658-18DOI Listing
December 2018
1 Read
3.731 Impact Factor

Role of a stem-loop structure in transcript stability.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

CagA is a secreted effector protein that contributes to gastric carcinogenesis. Previous studies showed that there is variation among strains in steady-state levels of CagA, and that a strain-specific motif downstream of the transcriptional start site (+59 motif) was associated with both high levels of CagA and premalignant gastric histology. The 5' untranslated region contains a predicted stem-loop-forming structure adjacent to the +59 motif. Read More

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http://dx.doi.org/10.1128/IAI.00692-18DOI Listing
December 2018
2 Reads

Peptidoglycan recognition protein 4 suppresses early inflammatory responses to and contributes to S1PR agonist-mediated disease attenuation.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Microbiology and Immunology, University of Maryland Medical School, Baltimore, Maryland, USA.

Incidence of whooping cough (pertussis), a bacterial infection of the respiratory tract caused by the bacterium , has reached levels not seen since the 1950s. Antibiotics fail to improve the course of disease unless administered early in infection. Therefore, there is an urgent need for the development of anti-pertussis therapeutics. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00601-18
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http://dx.doi.org/10.1128/IAI.00601-18DOI Listing
December 2018
3 Reads

Establishment, validation and application of a New World Primate model of ETEC disease for vaccine development.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 USA.

The establishment of an animal model that closely approximates ETEC disease in humans is critical for the development and evaluation of vaccines against this enteropathogen. Here, we evaluated the susceptibility of , a New World monkey species, to ETEC infection. Animals were challenged orogastrically with 10-10 colony forming units (CFU) of the human pathogenic CFA/I+ ETEC strain H10407 and examined for evidence of diarrhea and fecal shedding of bacteria. Read More

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http://dx.doi.org/10.1128/IAI.00634-18DOI Listing
December 2018

Downregulation of the central noradrenergic system by infection.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

School of Biology, Faculty of Biological Sciences, Clarendon Way, University of Leeds, Leeds LS2 9JT, UK

is associated with physiological effects in the host. Dysregulation of catecholamines in the central nervous system has previously been observed in chronically-infected animals. In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells The mechanism responsible for the NE suppression was found to be down-regulation of dopamine β-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine with down-regulation observed and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00789-18
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http://dx.doi.org/10.1128/IAI.00789-18DOI Listing
December 2018
4 Reads

PBP3 and PBP4 facilitate NOD1 agonist peptidoglycan fragment release and survival in stationary phase.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA

releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides. These molecules can be released by the actions of lytic transglycosylases or an amidase. Read More

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http://dx.doi.org/10.1128/IAI.00833-18DOI Listing
December 2018
2 Reads

Acknowledgment of Reviewers.

Infect Immun 2018 Dec 20;86(12). Epub 2018 Nov 20.

Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1128/IAI.00752-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246906PMC
December 2018

PPE37 is essential for heme-iron acquisition (HIA) and a defective PPE37 in BCG prevents HIA.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688

(Mtb), one of the world's leading causes of death, must acquire nutrients, such as iron, from the host to multiply and cause disease. Iron is an essential metal and Mtb possesses two different systems to acquire iron from its environment: Siderophore-Mediated Iron Acquisition (SMIA) and Heme-Iron Acquisition (HIA), involving uptake and degradation of heme to release ferrous iron. We have discovered that BCG, the tuberculosis vaccine strain, is severely deficient in HIA, and exploited this phenotypic difference between BCG and Mtb to identify genes involved in HIA by complementing BCG's defect with a fosmid library. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00540-18
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http://dx.doi.org/10.1128/IAI.00540-18DOI Listing
November 2018
3 Reads

Characterisation of the mode of action of Aurodox, a Type III Secretion System inhibitor from .

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK

Recent work has demonstrated that the polyketide natural product Aurodox, from is able to block the pathogenesis of the murine pathogen In this work we aimed to aimed gain a better understanding of the mechanism of action of the compound. We show that Aurodox downregulates the expression of the Type Three Secretion Systems of enteropathogenic and enterohaemorhagic Furthermore, we have used transcriptomic analysis to show that Aurodox inhibits the expression at the transcriptional level by repressing the master regulator, Our data support a model in which Aurodox acts upstream of and not directly on the secretion system itself. Finally, we have shown that Aurodox, unlike some traditional antibiotics, does not induce expression of RecA, which is essential for the production of Shiga toxin. Read More

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http://dx.doi.org/10.1128/IAI.00595-18DOI Listing
November 2018
3 Reads

Zebrafish G-CSFR maintains neutrophil number and function throughout the lifespan.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

School of Medicine, Deakin University, Geelong, Victoria, Australia

Granulocyte colony-stimulating factor receptor (G-CSFR), encoded by the gene, represents a major regulator of neutrophil production and function in mammals, with inactivating extracellular mutations identified in a cohort of neutropenia patients unresponsive to G-CSF treatment. This study sought to elucidate the role of the zebrafish G-CSFR by generating mutants harboring these inactivating extracellular mutations using genome editing. Zebrafish mutants possessed significantly decreased numbers of neutrophils from embryonic to adult stages, which were also functionally compromised, did not respond to G-CSF and displayed enhanced susceptibility to bacterial infection. Read More

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http://dx.doi.org/10.1128/IAI.00793-18DOI Listing
November 2018
1 Read

Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA

The Type VII secretion system ESX-5, which has been implicated in virulence, is activated at the transcriptional level by the phosphate starvation responsive Pst/SenX3-RegX3 signal transduction system. Deletion of , which encodes a Pst phosphate transporter component, causes constitutive activation of the response regulator RegX3, hyper-secretion of ESX-5 substrates and attenuation in the mouse infection model. We hypothesized that constitutive activation of ESX-5 secretion causes attenuation of the Δ mutant. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00660-18
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http://dx.doi.org/10.1128/IAI.00660-18DOI Listing
November 2018
3 Reads

Segmental variation in a duplicated pseudogene generates antigenic variants.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Paul G. Allen School for Global Animal Health and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman Washington, 99164.

is a prototypical highly antigenically variant bacterial pathogen, dependent on sequential generation of Major Surface Protein-2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression site and diversity is achieved by gene conversion of chromosomally encoded pseudogenes. Analysis of the full complement of pseudogenes in the St. Read More

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http://dx.doi.org/10.1128/IAI.00727-18DOI Listing
November 2018

Non-typeable invasive blood isolates are mainly phosphorylcholine negative and show decreased complement-mediated killing in comparison to colonizing isolates from the oropharynx, which is associated with lower binding of IgM and CRP to the bacterial surface.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, the Netherlands.

Non-typeable (NTHi) bacteria express various molecules that contribute to their virulence. The presence of phosphocholine (PCho) on NTHi lipooligosaccharide increases adhesion to epithelial cells and is an advantage for the bacterium enabling nasopharyngeal colonization, as measured in humans and animal models. However, when PCho is expressed on the lipooligosaccharide, it is also recognized by acute phase protein C-reactive protein (CRP) and PCho-specific antibodies, both potent initiators of the classical pathway of complement activation. Read More

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http://dx.doi.org/10.1128/IAI.00604-18DOI Listing
November 2018
1 Read

NOVEL ASSAY TO CHARACTERIZE NEUTROPHIL RESPONSES TO ORAL BIOFILMS.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, M5S 3E2

Neutrophils, the most numerous leukocytes, play an important role in maintaining oral health through interactions with oral microbial biofilms. Both neutrophil hyperactivity and the bacterial subversion of neutrophil responses can cause inflammation-mediated tissue damage as seen in periodontal disease. We describe here an assay that assesses neutrophil activation responses to mono-species biofilms bacteria in vitro based on surface expression of cluster of differentiation (CD) markers associated with various neutrophil functions. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00790-18
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http://dx.doi.org/10.1128/IAI.00790-18DOI Listing
November 2018
4 Reads

IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to infection.

Infect Immun 2018 Nov 19. Epub 2018 Nov 19.

School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK

Macrophages are important orchestrators of inflammation during bacterial infection acting both as effector cells and as regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and microbicidal potential have been described. Our previous work unveiled a positive and a negative correlation between levels of IFN-γ and IL-17A, respectively, and lung function in cystic fibrosis, particularly in patients chronically infected with This study sought to define key parameters in human anti-bacterial immunity under Th1- and Th17-dominated inflammatory conditions; the final aim was to identify unique characteristics that could be fine-tuned therapeutically to minimise tissue damage while maximising bacterial clearance. Read More

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http://dx.doi.org/10.1128/IAI.00814-18DOI Listing
November 2018
2 Reads

Interplay of nitric oxide synthase (NOS) and SrrAB in modulation of metabolism and virulence.

Infect Immun 2018 Nov 12. Epub 2018 Nov 12.

Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, FL, 32611-0700

nitric oxide synthase (saNOS) is a major contributor to virulence, stress resistance, and physiology, yet the specific mechanism(s) by which saNOS intersects with other known regulatory circuits are largely unknown. The SrrAB two-component system, which modulates gene expression in response to the reduced state of respiratory menaquinones, is a positive regulator of expression. Several SrrAB-regulated genes were also previously-shown to be induced in an aerobically-respiring mutant, suggesting potential interplay between saNOS and SrrAB. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00570-18
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http://dx.doi.org/10.1128/IAI.00570-18DOI Listing
November 2018
5 Reads

whole cell antigens offer protection against Rocky Mountain spotted fever in the canine host.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 (CVM-KSU)

Rocky Mountain Spotted Fever (RMSF) is a potentially fatal tick-borne disease in people and dogs. RMSF is reported in the USA and several countries in north, central and south Americas. The causing agent of this disease, , is transmitted by several species of ticks, including , and RMSF clinical signs generally include fever, headache, nausea, vomiting, muscle pain, lack of appetite, and rash. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00628-18
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http://dx.doi.org/10.1128/IAI.00628-18DOI Listing
November 2018
15 Reads

Phosphothreonine lyase promotes p65 degradation in a MAPK-MSK1-dependent manner.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

Bacterial phosphothreonine lyases are identified type III secretion system (T3SS) effectors that irreversibly dephosphorylate host mitogen-activated protein kinase (MAPK) signaling to promote infection. However, the effects of phosphothreonine lyase on nuclear factor-κB (NF-κB) signaling remain largely unknown. In this study, we detected significant phosphothreonine lyase-dependent p65 degradation during infection in macrophages, and this degradative effect was blocked by the protease inhibitor, MG132. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00508-18
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http://dx.doi.org/10.1128/IAI.00508-18DOI Listing
November 2018
4 Reads

Bacterial clearance enhanced by α2, 3- and α2, 6-sialyllactose via receptor-mediated endocytosis and phagocytosis.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea

Sialyllactose (SL) is a representative human milk oligosaccharide (HMO) of human breast milk. The roles of SL in infant brain development and immunity have been reported in previous studies. In this study, we identified the impact of SL on innate immunity. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00694-18
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http://dx.doi.org/10.1128/IAI.00694-18DOI Listing
November 2018
4 Reads
3.731 Impact Factor

Pathogenicity Island One is Expressed in the Chicken Intestine and Promotes Bacterial Proliferation.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

is a common cause of foodborne illness in the United States. This bacterium can be transmitted to humans via contaminated chicken meat and eggs, and virulence in humans requires the Type Three Secretion System-1 (TTSS-1), encoded on Pathogenicity Island One (SPI-1). Chickens often carry Enteritidis sub-clinically, obscuring the role of SPI-1 in facilitating bacterial colonization. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00503-18
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http://dx.doi.org/10.1128/IAI.00503-18DOI Listing
November 2018
2 Reads

Probiotic exopolysaccharide protects from systemic infection, inducing dual-functioning macrophages that restrict bacterial growth and limit inflammation.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL

causes severe systemic infection with high mortality rates. We previously identified exopolysaccharide (EPS) from a probiotic, , that induces anti-inflammatory macrophages with an M2 phenotype and protects mice from -induced colitis. We tested if EPS could protect from systemic infection induced by and found that EPS-treated mice had enhanced survival as well as reduced weight loss, systemic inflammation, and bacterial burden. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00791-18
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http://dx.doi.org/10.1128/IAI.00791-18DOI Listing
November 2018
2 Reads

Genomic, phenotypic, and virulence analysis oral and infective endocarditis isolates.

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA

, an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with pre-disposing cardiac valvular damage. Although commonly isolated from patients with IE, little is known about the factors that make any particular isolate more virulent than another or, indeed, whether significant differences in virulence exist among isolates. In this study we compared the genomes of a collection of strains, comprising both oral isolates and bloodstream isolates from patients diagnosed with IE. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00703-18
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http://dx.doi.org/10.1128/IAI.00703-18DOI Listing
November 2018
4 Reads

Antibodies to protein but not glycolipid structures are important for host defense against .

Infect Immun 2018 Nov 5. Epub 2018 Nov 5.

Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands

Antibody responses to () correlate with pulmonary clearance. However, -specific IgG antibodies can cross-react with the myelin glycolipid galactocerebroside (GalC) and cause neurologic disorders. We assessed whether anti-glycolipid antibody formation is part of the physiological immune response to We show that antibodies against -proteins and -glycolipids arise in serum of -infected children and mice. Read More

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http://dx.doi.org/10.1128/IAI.00663-18DOI Listing
November 2018
1 Read

recapitulates attributes of zoonotic human disease in a murine infection model.

Infect Immun 2018 Oct 29. Epub 2018 Oct 29.

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215

are Gram-negative pathogens that cause chronic systemic infection in farm animals and zoonotic infection in humans. Study of the genus has been hindered by the need for biosafety level three, select agent containment. , originally isolated from the desert pack rat, presented an opportunity to develop an alternative, non-select agent experimental model. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00255-18
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http://dx.doi.org/10.1128/IAI.00255-18DOI Listing
October 2018
4 Reads

The Evasive Enemy: Insights into the Virulence and Epidemiology of the Emerging Attaching and Effacing Pathogen, .

Infect Immun 2018 Oct 29. Epub 2018 Oct 29.

Department of Neuroscience, New York State Psychiatric Institute, Columbia University Medical Center, New York 10032, USA.

The diarrheic attaching and effacing (A/E) pathogen was first isolated from infants in Bangladesh in 1991, although the bacterium was initially classified as Subsequent genetic and biochemical interrogation of these isolates raised concerns about their initial taxonomic placement. It was not until 2003 that these isolates were reassigned to the novel taxon because they were genetically more closely related to , although they had diverged sufficiently to warrant a novel species name. Unfortunately, new isolates continue to be mistyped as enteropathogenic (EPEC) or enterohemorrhagic (EHEC) owing to shared traits, most notably the ability to form A/E lesions. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00254-18
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http://dx.doi.org/10.1128/IAI.00254-18DOI Listing
October 2018
9 Reads

Erratum for Nguyen et al., "Toll-Like Receptor 2 and Lipoprotein-Like Lipoproteins Enhance Staphylococcus aureus Invasion in Epithelial Cells".

Infect Immun 2018 Nov 25;86(11). Epub 2018 Oct 25.

Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany.

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http://iai.asm.org/lookup/doi/10.1128/IAI.00627-18
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http://dx.doi.org/10.1128/IAI.00627-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204693PMC
November 2018
4 Reads

Reply to "Bacterial Proliferation May Be the Key Component of Sepsis Mortality".

Authors:
Antonio De Maio

Infect Immun 2018 Nov 25;86(11). Epub 2018 Oct 25.

Division of Trauma, Critical Care, Burns and Acute Injury, Department of Surgery, School of Medicine, University of California, La Jolla, California, USA

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http://dx.doi.org/10.1128/IAI.00201-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204708PMC
November 2018
1 Read

Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during infection.

Infect Immun 2018 Oct 22. Epub 2018 Oct 22.

Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.

During infection the host utilizes a diverse array of processes to combat invaders, including the restriction of essential nutrients such as manganese. Similar to many other pathogens, possesses two manganese importers, MntH and MntABC. Several infection models have revealed a critical role for MntABC during staphylococcal infection. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00642-18
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http://dx.doi.org/10.1128/IAI.00642-18DOI Listing
October 2018
3 Reads

The host scaffolding protein Filamin A and the exocyst complex control exocytosis during InlB-mediated entry of .

Infect Immun 2018 Oct 22. Epub 2018 Oct 22.

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand

is a food-borne bacterium that causes gastroenteritis, meningitis, or abortion. induces its internalization (entry) into some human cells through interaction of the bacterial surface protein InlB with its host receptor, the Met tyrosine kinase. InlB and Met promote entry, in part, through stimulation of localized exocytosis. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00689-18
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http://dx.doi.org/10.1128/IAI.00689-18DOI Listing
October 2018
8 Reads

exploits CD209 receptors for promoting host dissemination and infection.

Infect Immun 2018 Oct 22. Epub 2018 Oct 22.

Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei, China

is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade into the small intestine via the Peyer's patches to initiate dissemination. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00654-18
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http://dx.doi.org/10.1128/IAI.00654-18DOI Listing
October 2018
6 Reads
3.730 Impact Factor

Overlapping Roles for IL-36 Cytokines in Protective Host Defense against Murine Pneumonia.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A.

(Lp) causes life-threatening pneumonia culminating in acute lung injury. Innate and adaptive cytokines play an important role in host defense against Lp infection. Interleukin (IL)-36 cytokines are recently described members of the larger IL-1 cytokine family known to exert potent inflammatory effects. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00583-18
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http://dx.doi.org/10.1128/IAI.00583-18DOI Listing
October 2018
6 Reads

The pneumococcal surface proteins PspA and PspC sequester host C4 binding protein to inactivate complement C4b on the bacterial surface.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK

Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00742-18
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http://dx.doi.org/10.1128/IAI.00742-18DOI Listing
October 2018
11 Reads

Increased mortality in mice following immunoprophylaxis therapy with high dosage of nicotinamide in persistent infections.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545

Bacterial persistence, known as non-inherited antibacterial resistance, is a contributing factor to the establishment of long-lasting chronic bacterial infections. In this study, we examined the ability of nicotinamide (NA) to potentiate different classes of antibiotics against persister cells. Here we demonstrate that addition of NA in models of infection resulted in a significant depletion of the persister population in response to various classes of antibiotics. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00592-18
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http://dx.doi.org/10.1128/IAI.00592-18DOI Listing
October 2018
64 Reads
3.730 Impact Factor

Characterization of host responses during acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

is an opportunistic pathogen that causes nosocomial pneumonia and infects patients with cystic fibrosis. lung infections are difficult to treat due to bacterial resistance to antibiotics, and strains with multi-drug resistance are becoming more prevalent. Here we examined the use of a small host defense peptide, innate defense regulator 1002 (IDR-1002), in an acute lung infection in vivo. Read More

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http://dx.doi.org/10.1128/IAI.00661-18DOI Listing
October 2018
1 Read

PPIases Mip and PpiB of contribute to surface translocation, growth at suboptimal temperature and infection.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Institut für Mikrobiologie, Technische Universität Braunschweig, 38106, Braunschweig

The gamma-proteobacterium is the causative agent of Legionnaires' disease, an atypical pneumonia that manifests itself with severe lung damage. , a common inhabitant of fresh water environments, replicates in free-living amoebae, and persists in biofilms in natural and man-made water systems. Its environmental versatility is reflected in its ability to survive and grow within a broad temperature range as well as its capability to colonize and infect a wide range of hosts including protozoa and humans. Read More

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http://dx.doi.org/10.1128/IAI.00939-17DOI Listing
October 2018
1 Read

Diffusely adherent strains isolated from healthy carriers suppress cytokine secretions of epithelial cells stimulated by inflammatory substances.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Graduate School of Human Life Science, Osaka City University, Osaka, Japan

Diarrheagenicity of diffusely adherent (DAEC) remains controversial. Previously, we found that motile DAEC strains isolated from diarrheal patients induced high levels of interleukin 8 (IL-8) secretion via Toll-like receptor 5 (TLR5). However, DAEC strains from healthy carriers hardly induced IL-8 secretion, irrespective of their possessing flagella. Read More

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http://dx.doi.org/10.1128/IAI.00683-18DOI Listing
October 2018
3.731 Impact Factor

Controlled infection immunization using delayed death drug treatment elicits protective immune responses to blood-stage malaria parasites.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia

Naturally acquired immunity to malaria is robust and protective against all strains of the same species of This develops as a result of repeated natural infection, taking several years to develop. Evidence suggests that apoptosis of immune lymphocytes due to uncontrolled parasite growth contributes to the slow acquisition of immunity. To hasten and augment the development of natural immunity, we studied controlled infection immunization (CII) using low dose exposure to different parasite species ( or ) in two rodent systems (BALB/c and C57BL/6) and in human volunteers, with drug therapy commencing at the time of initiation of infection. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00587-18
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http://dx.doi.org/10.1128/IAI.00587-18DOI Listing
October 2018
3 Reads

falciparum cGMP-dependent protein kinase interacts with a subunit of the parasite proteasome.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey, United States

Malaria is caused by the protozoan parasite, , which undergoes a complex life-cycle in a human host and a mosquito vector. The parasite's cGMP dependent protein kinase (PKG) is essential at multiple steps of the life-cycle. Phosphoproteomic studies in eyrthocytic stages and ookinetes have identified proteolysis as a major biological pathway dependent on PKG activity. Read More

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http://dx.doi.org/10.1128/IAI.00523-18DOI Listing
October 2018

Gene Expression Differences in Host Response to Infection.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Center for Global Health, Department of Medicine, Weill Cornell Medicine, New York, NY.

Schistosome worms infect over 200 million people worldwide. They live in the host's bloodstream and alter host immunity. Epidemiological data suggest that males and females have different responses to schistosome infection, but the effect of sex on systemic response is undetermined. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00291-18
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http://dx.doi.org/10.1128/IAI.00291-18DOI Listing
October 2018
6 Reads

Granzyme B is an essential mediator in CD8+ T cell killing of infected cells.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

There is established evidence that cytotoxic CD8+ T cells are important mediators of immunity against the bovine intracellular protozoan parasite However, the mechanism by which the specific CD8+ T cells kill parasitized cells is not understood. Although the predominant pathway used by human and murine CD8+ T cells to kill pathogen-infected cells is granule exocytosis, involving release of perforin and granzyme B, there is to date a lack of published information on the biological activities of bovine granzyme B. The present study set out to define the functional activities of bovine granzyme B and determine its role in mediating killing of -parasitized cells. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00386-18
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http://dx.doi.org/10.1128/IAI.00386-18DOI Listing
October 2018
4 Reads

HS: a Bacterial Defense Mechanism Against the Host Immune Response.

Infect Immun 2018 Oct 15. Epub 2018 Oct 15.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, 77555, USA.

The biological mediator hydrogen sulfide (HS) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial HS provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections, and Elevations in HS increased the resistance of both species to immune-mediated killing. Clearance of infections with wild type and genetically HS-deficient and was compared and in mouse models of abdominal sepsis and burn wound infection. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00272-18
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http://dx.doi.org/10.1128/IAI.00272-18DOI Listing
October 2018
9 Reads

OxyR regulates the transcriptional response to hydrogen peroxide.

Infect Immun 2018 Oct 8. Epub 2018 Oct 8.

Vanderbilt Institute for Infection, Immunology, and Inflammation and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA

is a Gram-negative opportunistic pathogen that causes diverse infections, including pneumonia, bacteremia, and wound infections. Due to multiple intrinsic and acquired antimicrobial-resistance mechanisms, isolates are commonly multi-drug resistant and infections are notoriously difficult to treat. The World Health Organization recently highlighted carbapenem-resistant as a 'critical priority' for the development of new antimicrobials because of the risk to human health posed by this organism. Read More

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http://dx.doi.org/10.1128/IAI.00413-18DOI Listing
October 2018
2 Reads
3.731 Impact Factor

Supports Infection in Macrophages and .

Infect Immun 2018 Oct 8. Epub 2018 Oct 8.

Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX USA

Rickettsiae can cause life-threatening infections in humans. Macrophages are one of the initial targets for rickettsiae after inoculation by ticks. However, it remains poorly understood how rickettsiae remain free in macrophages prior to establishing their infection in microvascular endothelial cells. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00651-18
Publisher Site
http://dx.doi.org/10.1128/IAI.00651-18DOI Listing
October 2018
3 Reads
3.731 Impact Factor