602 results match your criteria Infection and Drug Resistance [Journal]


Cycloserine for treatment of multidrug-resistant tuberculosis: a retrospective cohort study in China.

Infect Drug Resist 2019 29;12:721-731. Epub 2019 Mar 29.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200032, China.

Purpose: Cycloserine has been used in multidrug-resistant tuberculosis (MDR-TB) treatment since the 1950s. We evaluated the efficacy and safety of cycloserine and sought to clarify the role of cycloserine for treatment of simple MDR-TB, pre-extensively drug-resistant tuberculosis (pre-XDR-TB), and extensively drug-resistant tuberculosis (XDR-TB).

Materials And Methods: A retrospective observational study was performed in Zhejiang Province, China. Read More

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http://dx.doi.org/10.2147/IDR.S195555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445236PMC

Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against induced liver pathology.

Infect Drug Resist 2019 28;12:709-719. Epub 2019 Mar 28.

Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.

Introduction: Schistosomiasis is one of the most prevalent parasitic infections in developing countries. Although chemotherapy is one of the main strategies in controlling the disease, it is less effective in reversal of schistosome-induced pathology especially in the chronic and advanced stages of schistosomiasis. New strategies and prospective therapeutic agents with antifibrotic effects are needed. Read More

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https://www.dovepress.com/eugenol-a-potential-schistosomicid
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http://dx.doi.org/10.2147/IDR.S196544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445185PMC
March 2019
1 Read

What drives inappropriate use of antibiotics? A mixed methods study from Bahawalpur, Pakistan.

Infect Drug Resist 2019 26;12:687-699. Epub 2019 Mar 26.

School of Management, Massey Business School, Massey University, Auckland, New Zealand.

Purpose: This study investigates the knowledge, attitudes and practices of the general public regarding the use of antibiotics in community pharmacy, in Pakistan.

Methods: This is a mixed method study where data were collected through a validated questionnaire and semi-structured interviews. Convenience sampling techniques were used to recruit participants from the general public of Bahawalpur, Pakistan who visited pharmacies to purchase antibiotics between 1 June 2018 and 31 July 2018. Read More

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https://www.dovepress.com/what-drives-inappropriate-use-of-a
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http://dx.doi.org/10.2147/IDR.S189114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440533PMC
March 2019
1 Read

Risk factors with the development of infection with tigecycline- and carbapenem-resistant .

Infect Drug Resist 2019 20;12:667-674. Epub 2019 Mar 20.

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China,

Background: Tigecycline is regarded as a last resort treatment for carbapenem-resistant (CREC) infections, and increasing numbers of tigecycline- and carbapenem-resistant (TCREC) isolates have been reported in recent years. However, risk factors and clinical impacts of these isolates are poorly characterized.

Patients And Methods: We conducted a retrospective case-case-control study of hospitalized patients with TCREC infection during the period 2012-2016 in Chongqing, China. Read More

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http://dx.doi.org/10.2147/IDR.S189941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430992PMC
March 2019
1 Read

High prevalence of KPC-2-producing hypervirulent causing meningitis in Eastern China.

Infect Drug Resist 2019 18;12:641-653. Epub 2019 Mar 18.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China,

Background: has been the leading causative pathogen for adult bacterial meningitis in several Asian countries. The clinical and microbiological characteristics of meningitis in mainland China are still unknown.

Materials And Methods: The clinical data of patients with meningitis from January 2011 to July 2017 in a tertiary hospital were retrospectively evaluated. Read More

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https://www.dovepress.com/high-prevalence-of-kpc-2-producing
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http://dx.doi.org/10.2147/IDR.S191892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430001PMC
March 2019
4 Reads

Susceptibility rates of clinically important bacteria collected from intensive care units against colistin, carbapenems, and other comparative agents: results from Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART).

Infect Drug Resist 2019 14;12:627-640. Epub 2019 Mar 14.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan,

Objectives: This study aimed to determine the in vitro susceptibility of commonly encountered Gram-negative bacilli (GNB) recovered from patients admitted to intensive care units (ICUs) in Taiwan against colistin, carbapenems, and other comparative agents.

Methods: In total, 758 nonduplicate GNB isolates were obtained from clinical specimens of ICU patients at seven medical centers in 2016. Minimum inhibitory concentrations (MICs) were determined using the Vitek 2 susceptibility system. Read More

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http://dx.doi.org/10.2147/IDR.S194482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421902PMC
March 2019
2 Reads

System dynamics modeling of public health services provided by China CDC to control infectious and endemic diseases in China.

Infect Drug Resist 2019 13;12:613-625. Epub 2019 Mar 13.

Department of Military Health Service Management, College of Military Health Service Management, Second Military Medical University, Shanghai, China,

Background: Infectious and endemic diseases are a serious public health concern worldwide, and their prevention and treatment are globally controversial. This study aimed to establish an system dynamics (SD) model to analyze the factors influencing public health services provided by the Chinese Centers for Disease Control and Prevention (China CDC) to implement infectious and endemic disease control in China, by establishing more effective interventions to provide public health services and thus achieving the goal of controlling infectious and endemic diseases.

Materials And Methods: An SD model was constructed using the Vensim DSS program. Read More

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https://www.dovepress.com/system-dynamics-modeling-of-public
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http://dx.doi.org/10.2147/IDR.S185177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422414PMC
March 2019
3 Reads

Increase in antibiotic resistant in a University Hospital in Japan.

Infect Drug Resist 2019 12;12:597-602. Epub 2019 Mar 12.

Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.

Background: Eradication effectively prevents -associated diseases; however, antibiotic resistance has increased throughout Japan and worldwide. This study aimed to assess rates of resistance to antibiotics; amoxicillin, clarithromycin and metronidazole in a University Hospital in Japan.

Materials And Methods: (208 strains) were isolated from patients at the Okayama University Hospital in Japan. Read More

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http://dx.doi.org/10.2147/IDR.S196452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419596PMC

In vitro activity and pharmacodynamic/pharmacokinetic parameters of clarithromycin and azithromycin: why they matter in the treatment of respiratory tract infections.

Authors:
Ross J Davidson

Infect Drug Resist 2019 8;12:585-596. Epub 2019 Mar 8.

Department of Pathology and Laboratory Medicine, Division of Microbiology, Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada,

Clarithromycin and azithromycin are second-generation macrolides established and widely used for treating a range of upper and lower respiratory tract infections. Extensive clinical trials data indicate that these drugs are highly effective in these applications and broadly comparable in their clinical and microbiological effectiveness. However, consideration of pharmacokinetic, metabolic, and tissue-penetration data, including the significant antibacterial activity of the metabolite 14-hydroxy-clarithromycin, plus the findings of pharmacodynamic modeling, provide evidence that the long half-life and lower potency of azithromycin predispose this agent to select for resistant isolates. Read More

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http://dx.doi.org/10.2147/IDR.S187226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413744PMC
March 2019
1 Read

Characterization of the most common gene mutations associated with ethambutol resistance in isolates from Iran.

Infect Drug Resist 2019 6;12:579-584. Epub 2019 Mar 6.

Khuzestan Tuberculosis Regional Reference Laboratory, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Ethambutol (Emb) is one of the first-line drugs in the standard combination therapy for tuberculosis; however, due to the rapid increase in Emb resistance among clinical isolates of (MTB), early detection of Emb resistance is desirable. As the operon is considered involved in resistance to Emb, this study aimed to analyze the most common mutations within the operon among MTB isolates from Iran to find any correlations of these mutations with Emb resistance.

Methods: A total of 307 clinical isolates of MTB were screened for Emb resistance by phenotypic drug-susceptibility testing. Read More

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http://dx.doi.org/10.2147/IDR.S196800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411316PMC

High rates of CTX-M group-1 extended-spectrum β-lactamases producing from pets and their owners in Faisalabad, Pakistan.

Infect Drug Resist 2019 6;12:571-578. Epub 2019 Mar 6.

Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Purpose: Pet animals have been considered a potential carrier of clinically important multi-drug-resistant . However, little is known about the role of pets as reservoirs of extended-spectrum β-lactamase (ESBL) producing in Pakistan. This study was designed to determine the prevalence and genetic relatedness of ESBL-producing multidrug-resistant in pets, their owners, and veterinary professionals. Read More

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http://dx.doi.org/10.2147/IDR.S189884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411320PMC

Clinical utility of tafenoquine in the prevention of relapse of malaria: a review on the mode of action and emerging trial data.

Infect Drug Resist 2019 6;12:553-570. Epub 2019 Mar 6.

Institute of Tropical Medicine, Eberhard Karls University Tübingen, Tübingen, Germany,

Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of , including dormant liver stages - so called hypnozoites. Its long half-life of ~15 days is allowing for a single exposure regimen. It has been under development since 1980 and received approval by the US Food and Drug Administration in summer 2018 as an anti-relapse drug for malaria in patients aged 16 years and older and for prophylaxis of malaria caused by any species in adults. Read More

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http://dx.doi.org/10.2147/IDR.S151031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411314PMC

Antimicrobial activities of ceftazidime-avibactam, ceftolozane-tazobactam, and other agents against , , and isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016.

Infect Drug Resist 2019 4;12:545-552. Epub 2019 Mar 4.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan,

Objective: The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016.

Materials And Methods: In total, 300 non-duplicate isolates of (n=100), (n=100), and (n=100) collected from 300 patients were studied. The minimum inhibitory concentrations (MICs) of these isolates to antimicrobial agents were determined using the broth microdilution method. Read More

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http://dx.doi.org/10.2147/IDR.S193638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404672PMC
March 2019
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Genetic basis for metronidazole and clarithromycin resistance in strains isolated from patients with gastroduodenal disorders.

Infect Drug Resist 2019 4;12:535-543. Epub 2019 Mar 4.

Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: The aim of this study was to evaluate the antimicrobial resistance and genetic basis for metronidazole (Mtz) and clarithromycin (Cla) resistance in strains of , isolated from patients with gastroduodenal disorders.

Patients And Methods: A total of 157 . isolates (from 22 gastric cancer, 38 peptic ulcer disease, and 97 non-ulcer dyspepsia patients) were analyzed for drug susceptibility to Mtz and Cla, by gradient diffusion test (E-test, MAST). Read More

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http://dx.doi.org/10.2147/IDR.S192942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404679PMC
March 2019
4 Reads

Loop-mediated isothermal amplification for detection of in respiratory specimens of hospitalized patients in Ahvaz, southwest Iran.

Infect Drug Resist 2019 1;12:529-534. Epub 2019 Mar 1.

Department of Pathobiology, School of Veterinary, University of Shahid Chamran, Ahvaz, Iran.

Background: Legionnaires' disease is an important public health problem that can cause substantial mortality and morbidity. Legionnaires' disease-risk estimation may be compromised by uncertainties in -detection methods. The aim of this study was the detection of in respiratory specimens of hospitalized patients with respiratory symptoms by culture, PCR, and loop-mediated isothermal amplification (LAMP) methods. Read More

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http://dx.doi.org/10.2147/IDR.S198099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402708PMC
March 2019
2 Reads

Profiles of hematological parameters in and malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia.

Infect Drug Resist 2019 5;12:521-527. Epub 2019 Mar 5.

School of Medicine, Department of Medical Laboratory Science, College of Health Science and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Malaria is a major health problem in the tropics, with 300-500 million cases and 1.1-2.7 million deaths occurring annually. Read More

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http://dx.doi.org/10.2147/IDR.S184489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407901PMC

Characterization of a novel -harboring IncFII plasmid and an -bearing IncI2 plasmid in a single ST167 clinical isolate.

Infect Drug Resist 2019 1;12:511-519. Epub 2019 Mar 1.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, China,

Background And Purpose: The spread of the plasmid-mediated, colistin-resistance gene into New Delhi metallo-β-lactamase (NDM)-producing bacterial isolates can cause untreatable infections. In this study, we conducted a molecular characterization of a novel, conjugative, -positive IncFII plasmid (pNDM-EC16-50) together with an -bearing IncI2 plasmid in a single ST167 clinical isolate EC16-50.

Methods And Results: EC16-50, which belongs to the strain ST167 and phylogroup A, was identified to co-produce NDM-5 and MCR-1. Read More

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http://dx.doi.org/10.2147/IDR.S192998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402710PMC
March 2019
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Impact of a probiotic-based hospital sanitation on antimicrobial resistance and HAI-associated antimicrobial consumption and costs: a multicenter study.

Infect Drug Resist 2019 27;12:501-510. Epub 2019 Feb 27.

CIAS Research Interdepartmental Centre, Departments of Architecture and Medical Sciences, University of Ferrara, Ferrara, Italy,

Purpose: Antimicrobial resistance (AMR) is one of the major threats to human health, and the high frequency of resistant pathogens in the hospital environment can contribute to the transmission of difficult-to-treat health care-associated infections (HAIs). We recently reported that, compared with conventional chemical cleaning, the use of a microbial-based sanitation strategy (Probiotic Cleaning Hygiene System [PCHS]) was associated with remodulation of hospital microbiota and reduction of HAI incidence. Here, we aimed to analyze the impact of PCHS on AMR and related effects, such as HAI-associated antimicrobial drug consumption and costs. Read More

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http://dx.doi.org/10.2147/IDR.S194670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398408PMC
February 2019

Rational use of antibiotics in an intensive care unit: a retrospective study of the impact on clinical outcomes and mortality rate.

Infect Drug Resist 2019 26;12:493-499. Epub 2019 Feb 26.

Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.

Background: Intensive care units (ICUs) are specialized units where patients with critical conditions are admitted for getting specialized and individualized medical treatment. High mortality rates have been observed in ICUs, but the exact reason and factors affecting the mortality rates have not yet been studied in the local population in Pakistan.

Aim: This study was aimed to determine rational use of antibiotic therapy in ICU patients and its impact on clinical outcomes and mortality rate. Read More

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http://dx.doi.org/10.2147/IDR.S187836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396654PMC
February 2019
1 Read

Extensively drug-resistant Gram-negative bacterial bloodstream infection in hematological disease.

Infect Drug Resist 2019 26;12:481-491. Epub 2019 Feb 26.

Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China,

Background: Extensively drug-resistant Gram-negative bacterial (XDR-GNB) bloodstream infection (BSI) is difficult to treat and is associated with a high mortality rate in patients with hematological diseases. The aim of this study is to investigate the predisposing risk factors and the efficacy of the antibiotic treatment in these patients, including exploration of efficacy and adverse effects of high-dose tigecycline.

Methods: Between January 2013 and December 2017, 27 XDR-GNB BSI patients with hematological diseases were diagnosed and retrospectively reviewed in the current study. Read More

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http://dx.doi.org/10.2147/IDR.S191462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396657PMC
February 2019
1 Read

Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant strains isolated from hospitalized patients in Guangdong Province, China.

Infect Drug Resist 2019 25;12:447-459. Epub 2019 Feb 25.

Department of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China,

Purpose: The main objective of this study was to decipher the prevalence, antimicrobial resistance, major virulence genes and the molecular characteristics of methicillin-resistant (MRSA) isolated from different clinical sources in southern China.

Materials And Methods: The present study was performed on 187 non-duplicate clinical isolates collected from three tertiary hospitals in Guangdong Province, China, 2010-2016. Antimicrobial susceptibility testing was performed by the disk diffusion method and by measuring the minimum inhibitory concentration. Read More

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http://dx.doi.org/10.2147/IDR.S192611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394240PMC
February 2019
1 Read

Treatment of late bacterial infections resulting from soft-tissue filler injections.

Infect Drug Resist 2019 20;12:469-480. Epub 2019 Feb 20.

Department of Microbiology, Medical University of Warsaw, Warsaw, Poland,

Purpose: Late bacterial infections (LBIs) after esthetic facial augmentation using hyaluronic acid (HA) fillers are relatively rare yet severe complications that are difficult to treat. No adequate treatment standards have hitherto been formulated. We have bridged this gap by formulating a treatment scheme based on the principles of treating foreign-body implantation-related infections and treating bacterial growth in the form of biofilm. Read More

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https://www.dovepress.com/treatment-of-late-bacterial-infect
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http://dx.doi.org/10.2147/IDR.S186996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390860PMC
February 2019
7 Reads

Epidemiology of carbapenem-resistant Enterobacteriaceae: a 5-year experience at a tertiary care hospital.

Infect Drug Resist 2019 20;12:461-468. Epub 2019 Feb 20.

Clinical Microbiology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Purpose: The incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing worldwide. Ertapenem resistance is mediated by non-carbapenemase mechanisms, and has less of an effect on susceptibility to imipenem and meropenem. This study aimed to study the epidemiology of CRE, and to compare risk factors and related mortality between non-susceptibility to ertapenem alone Enterobacteriaceae (NSEE), with non-susceptibility to other carbapenems (imipenem, meropenem, or doripenem) Enterobacteriaceae (NSOCE) at a tertiary care hospital in Thailand. Read More

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https://www.dovepress.com/epidemiology-of-carbapenem-resista
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http://dx.doi.org/10.2147/IDR.S192540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390851PMC
February 2019
1 Read

Detection of four patients who were infected by in Vietnam.

Infect Drug Resist 2019 18;12:439-445. Epub 2019 Feb 18.

Department of Molecular Diagnosis, National Hospital for Tropical Diseases, Hanoi, Vietnam.

Introduction: lives as a parasite in the portal vein causing intestinal lesions. It also lives in the liver, spleen, and the vein of the urinary bladder causing lesions in the urinary system. Angola is an endemic area of , which causes lesions in the urinary system, including the urinary bladder. Read More

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http://dx.doi.org/10.2147/IDR.S179746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388730PMC
February 2019
1 Read

The efficacy and safety of nemonoxacin compared with levofloxacin in the treatment of community-acquired pneumonia: a systemic review and meta-analysis of randomized controlled trials.

Infect Drug Resist 2019 14;12:433-438. Epub 2019 Feb 14.

Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan,

Objectives: This meta-analysis aims to assess the clinical efficacy and safety of nemonoxacin in comparison with levofloxacin in treating community-acquired pneumonia (CAP).

Materials And Methods: The Pubmed, Embase, ClinicalTrials.gov. Read More

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http://dx.doi.org/10.2147/IDR.S193233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388749PMC
February 2019
2 Reads

Metabolic mechanism of ceftazidime resistance in .

Infect Drug Resist 2019 13;12:417-429. Epub 2019 Feb 13.

Center for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory for Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, University City, Guangzhou 510006, People's Republic of China,

Background: Microbial metabolism confounds antibiotic efficacy. However, information regarding effect of metabolism on cephalosporin antibiotics-mediated killing and is largely absence, although the drugs are widely used in clinic and the bacteria are pathogens to both human and aquaculture animals.

Purpose: This study explores the metabolome of cephalosporin antibiotic-resistant and analyzes the role of bacterial metabolism in drug and multidrug-resistance. Read More

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http://dx.doi.org/10.2147/IDR.S179639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388739PMC
February 2019
5 Reads

Biochemical but not compositional recovery of skin mucosal microbiome communities after disruption.

Infect Drug Resist 2019 13;12:399-416. Epub 2019 Feb 13.

Department of Biological Sciences, Sam Houston State University, Huntsville, TX, USA,

Background: The microbiomes of animals are complex communities that strongly affect the health of the hosts. Microbiomes on mucosal surfaces have the highest densities and most extensive biochemical exchanges with the hosts. Although antibiotics are potent tools to manage infections, they can disrupt the normal microbiota, causing numerous side effects. Read More

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http://dx.doi.org/10.2147/IDR.S185992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388737PMC
February 2019

Epidemiologic analysis and control strategy of infection in intensive care units in a teaching hospital of People's Republic of China.

Infect Drug Resist 2019 12;12:391-398. Epub 2019 Feb 12.

Department of Infectious Diseases, Key Laboratory of Infectious and Parasitic Diseases in Chongqing, Chongqing 400016, People's Republic of China.

Background: (KP) is the most common pathogen isolated in intensive care units (ICUs) and the most frequently encountered carbapenemase-producing Enterobacteriaceae. Increasing antimicrobial drug resistance, especially in carbapenem-resistant KP (CRKP), can limit the choice of antibiotics used for the treatment of infectious diseases and further poses a negative impact on patient outcome. However, the reason behind this increasing resistance is not well known. Read More

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http://dx.doi.org/10.2147/IDR.S189154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388741PMC
February 2019

Plasmid-mediated colistin resistance gene in and isolated from market retail fruits in Guangzhou, China.

Infect Drug Resist 2019 11;12:385-389. Epub 2019 Feb 11.

Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China,

Background: As a result of the growing prevalence of the plasmid-mediated mobile colistin resistance gene among Gram-negative bacteria, the surveillance of has been globally applied. In our study, we aimed to shed light on the possibility of transmission of -resistant isolates through market retail fruits.

Methods And Results: Herein, 133 different fruit surface samples were collected and screened for the different MCR variants ( to ) using PCR and confirmed with sequencing. Read More

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http://dx.doi.org/10.2147/IDR.S194635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377047PMC
February 2019
2 Reads

New Delhi metallo-β-lactamase-producing isolates among late-onset VAP patients: multidrug-resistant pathogen and poor outcome.

Infect Drug Resist 2019 11;12:373-384. Epub 2019 Feb 11.

Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: spp. are increasingly important microbes involved in late-onset ventilator-associated pneumonia (VAP).

Purpose: The aims of this study were to determine the prevalence of New Delhi metallo-β-lactamase (MβL) (NDM-1)-producing spp. Read More

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http://dx.doi.org/10.2147/IDR.S186924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377045PMC
February 2019

Clinical outcome of bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study.

Infect Drug Resist 2019 11;12:359-371. Epub 2019 Feb 11.

Department of Cell Biology, School of Medicine, Nankai University, Tianjin, China,

Background: Extended-spectrum β-lactamase-producing (ESBL-EC) is one of the main antimicrobial-resistant pathogens. Little data are available on how biofilm formation (BF) contributes to EC-caused bloodstream infection (BSI) in cancer patients. This study investigated the impact of BF on clinical outcomes of cancer patients with EC-caused BSI. Read More

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http://dx.doi.org/10.2147/IDR.S192072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377049PMC
February 2019
1 Read

Mutations in play an important role in ciprofloxacin-resistant .

Infect Drug Resist 2019 8;12:261-272. Epub 2019 Feb 8.

Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China,

Purpose: To investigate the main resistance mechanisms to fluoroquinolones (FQs) in and also to investigate the effect of time and concentration on mutations in resistance genes.

Materials And Methods: The clinical isolates of which are sensitive to ciprofloxacin (CIP) or levofloxacin (LEV) were collected. The isolates were incubated with different concentrations of CIP or LEV for 5 days and the minimal inhibitory concentrations (MICs) of CIP, LEV and ofloxacin (OFX) were measured. Read More

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http://dx.doi.org/10.2147/IDR.S182272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371945PMC
February 2019

The blood transcriptional signature for active and latent tuberculosis.

Infect Drug Resist 2019 30;12:321-328. Epub 2019 Jan 30.

Department of Respiration, The First Hospital of Jiaxing, The First Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.

Background: Although the incidence of tuberculosis (TB) has dropped substantially, it still is a serious threat to human health. And in recent years, the emergence of resistant bacilli and inadequate disease control and prevention has led to a significant rise in the global TB epidemic. It is known that the cause of TB is infection. Read More

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http://dx.doi.org/10.2147/IDR.S184640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363485PMC
January 2019

Alternative eradication regimens for infection in Indonesian regions with high metronidazole and levofloxacin resistance.

Infect Drug Resist 2019 31;12:345-358. Epub 2019 Jan 31.

Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan,

Background: The prevalence of resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens.

Methods: We determined the minimum inhibitory concentrations (MICs) of five alternative antibiotics for (rifaximin, rifabutin, furazolidone, garenoxacin, and sitafloxacin) using the agar dilution method and assessed mutations associated with antibiotic resistance using next-generation sequencing. Read More

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http://dx.doi.org/10.2147/IDR.S187063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362932PMC
January 2019
1 Read

The impact of initial antibiotic treatment failure: real-world insights in patients with complicated, health care-associated intra-abdominal infection.

Infect Drug Resist 2019 31;12:329-343. Epub 2019 Jan 31.

Department of Medicine, Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena - Instituto de Biomedicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain,

Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation of antibiotic therapy) for health care-associated infections across five countries.

Patients And Methods: Data were collected from a retrospective chart review of patients aged ≥18 years with health care-associated complicated intra-abdominal infection (cIAI). Potential risk factors for IAT failure were identified using logistic regression analyses. Read More

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http://dx.doi.org/10.2147/IDR.S184116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362915PMC
January 2019
2 Reads

Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis.

Infect Drug Resist 2019 29;12:311-319. Epub 2019 Jan 29.

Community and Occupational Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt,

Background: Neonatal sepsis (NS) is an important cause of morbidity and mortality among newborns. Its diagnosis depends mainly on blood culture that takes at least 48 hours to give results. Therefore, searching for biomarkers for early diagnosis is of value. Read More

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http://dx.doi.org/10.2147/IDR.S191533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357881PMC
January 2019
1 Read

Platelet-rich plasma plays an antibacterial, anti-inflammatory and cell proliferation-promoting role in an in vitro model for diabetic infected wounds.

Infect Drug Resist 2019 29;12:297-309. Epub 2019 Jan 29.

Department of Endocrinology, Southwest Hospital, Army Medical University, Chongqing, People's Republic of China,

Aim: This study was designed to examine the potential mechanism underlying these roles of platelet-rich plasma in treating diabetic foot ulcers (DFUs).

Methods: and HaCaT were co-cultured under high glucose conditions to serve as an in vitro model for infected cells in DFUs. Platelet-rich gel (PRG) or extract liquid of platelet-rich gel (EPG) were used to interfere with the model to observe the growth of HaCaT cells and , and the effect of miR-21 changes in HaCaT cells on PDCD4, NF-κB activity and related inflammatory factors. Read More

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https://www.dovepress.com/platelet-rich-plasma-plays-an-anti
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http://dx.doi.org/10.2147/IDR.S186651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357877PMC
January 2019
3 Reads

Comparative analysis of KPC-2-encoding chimera plasmids with multi-replicon IncR:Inc:IncN1 or IncFII:Inc:IncN1.

Infect Drug Resist 2019 24;12:285-296. Epub 2019 Jan 24.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China,

Background: IncR, IncFII, IncpA1763-KPC, and IncN1 plasmids have been increasingly found among species, but plasmids with hybrid structures derived from the above-mentioned incompatibility groups have not yet been described.

Methods: Plasmids p721005-KPC, p504051-KPC, and pA3295-KPC were fully sequenced and compared with previously sequenced related plasmids pHN84KPC (IncR), pKPHS2 (IncFII), pKOX_NDM1 (IncFII), pHN7A8 (IncFII), and R46 (IncN1).

Results: The backbone of p721005-KPC/p504051-KPC was a hybrid of the entire 10-kb IncR-type backbone from pHN84KPC, the entire 64. Read More

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http://dx.doi.org/10.2147/IDR.S189168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353027PMC
January 2019
1 Read

Selection between aztreonam and cephalosporins for treatment of infections with pseudomonads needs more caution.

Authors:
Bhoj R Singh

Infect Drug Resist 2019 24;12:281-284. Epub 2019 Jan 24.

Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, India,

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http://dx.doi.org/10.2147/IDR.S193132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353025PMC
January 2019

Prevalence and predictors of occult hepatitis C virus infection among Egyptian patients who achieved sustained virologic response to sofosbuvir/daclatasvir therapy: a multi-center study.

Infect Drug Resist 2019 22;12:273-279. Epub 2019 Jan 22.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt,

Background: Occult hepatitis C virus (HCV) infection (OCI) is characterized by the detection of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) and/or hepatocytes with undetectable HCV-RNA or antibodies in the serum. In this study, we tried to evaluate the prevalence and possible predictors of OCI in patients who achieved sustained virologic response (SVR) post sofosbuvir/daclatasvir (SOF/DCV) therapy.

Patients And Methods: A cross-sectional multicenter study was designed to enroll 1,280 HCV-infected patients who received SOF (400 mg) plus DCV (60 mg) once daily ± ribavirin regimen for 12 weeks and achieved SVR 12 weeks post treatment. Read More

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http://dx.doi.org/10.2147/IDR.S181638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348965PMC
January 2019

Central nervous system infection mimicking central nervous system idiopathic inflammatory demyelinating disease.

Infect Drug Resist 2019 22;12:255-259. Epub 2019 Jan 22.

Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China,

(Lm) is an opportunistic pathogen that causes life-threatening infections, especially when the central nervous system (CNS) is involved. Here, we report a patient who was admitted to the hospital with headache, dizziness, right side facial numbness, and hoarseness. The individual was initially diagnosed with central nervous system idiopathic inflammatory demyelinating disease (CNS IIDD), which was then found to be CNS Lm infection (brainstem and cervical cord infection). Read More

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http://dx.doi.org/10.2147/IDR.S189930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348973PMC
January 2019

Prevalence and antimicrobial resistance of species isolated from diarrheal patients in Ahvaz, southwest Iran.

Infect Drug Resist 2019 22;12:249-253. Epub 2019 Jan 22.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Introduction: Shigellosis is a significant global human health problem, and is in charge of almost 165 million cases of this disease annually, of whom 163 million cases are in developing countries and 1.5 million cases are in developed countries. The main aims of the current survey were to identify spp. Read More

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http://dx.doi.org/10.2147/IDR.S187861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348961PMC
January 2019
1 Read

Treatment of severe ventriculitis caused by extensively drug-resistant by intraventricular lavage and administration of colistin.

Infect Drug Resist 2019 21;12:241-247. Epub 2019 Jan 21.

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China,

Background: Severe ventriculitis (SV) caused by multidrug-resistant bacteria is associated with high morbidity and mortality in neurosurgical patients. This study assessed the outcomes of patients with SV caused by who were treated by intraventricular (IVT) lavage and colistin administration.

Methods: This retrospective study included consecutive patients with SV caused by who were admitted at the Neurosurgical Department of Shanghai Tenth People's Hospital from January 2014 to September 2017. Read More

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http://dx.doi.org/10.2147/IDR.S186646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345184PMC
January 2019
3 Reads

Resistance rates of non- infections in Taiwan after the revision of 2012 Clinical and Laboratory Standards Institute breakpoints.

Infect Drug Resist 2019 15;12:235-240. Epub 2019 Jan 15.

Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan,

Purpose: In 2012, the Clinical and Laboratory Standards Institute (CLSI) revised its breakpoints for drugs and species because of the increase in non- infections and their drug resistance. Following global trends, the non- candidemia resistance rate has increased in Taiwan as well. To update the antifungal susceptibility of non- candidemia isolates, we conducted a multicenter study using the revised break points. Read More

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http://dx.doi.org/10.2147/IDR.S184884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338119PMC
January 2019
1 Read

Gene drives as a response to infection and resistance.

Infect Drug Resist 2019 14;12:229-234. Epub 2019 Jan 14.

Department of Healthcare Administration, Sawyer Business School, Suffolk University, Boston, MA, USA,

Vector-borne infectious diseases continue to be a major threat to public health. Although some prevention and treatment modalities exist for these diseases, resistance to such modalities, exacerbated by global climate change, remains a fundamental challenge. Developments in genomic engineering technologies present a new front in battling vector-borne illnesses; however, there is a lack of consensus over the scope and consequences of these approaches. Read More

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http://dx.doi.org/10.2147/IDR.S187424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336018PMC
January 2019

Molecular characterization of the gene and its association with the frequency of plasmid pKLC102 and PAPI-1 pathogenicity island.

Infect Drug Resist 2019 11;12:221-227. Epub 2019 Jan 11.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: is the most common opportunistic pathogen associated with a broad range of infections, including cystic fibrosis, ocular, otitis media, and burn infections. The aim of this study was to show the frequency of the gene, and its association with plasmid pKLC102 and PAPI-1 pathogenicity island among strains.

Methods: The samples were collected from patients with cystic fibrosis, ocular, otitis media, and burn infections between January 2016 and November 2017. Read More

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https://www.dovepress.com/molecular-characterization-of-the-
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http://dx.doi.org/10.2147/IDR.S188527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333160PMC
January 2019
8 Reads

Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China.

Infect Drug Resist 2019 10;12:211-219. Epub 2019 Jan 10.

Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563003, China,

Objectives: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-TB burden and resource-limited province of China. Read More

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http://dx.doi.org/10.2147/IDR.S188538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330984PMC
January 2019

Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.

Infect Drug Resist 2019 11;12:185-210. Epub 2019 Jan 11.

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia,

Background: Mannose-binding lectin (MBL) or mannose-binding protein (MBP), encoded by MBL2 gene and secreted by the liver, activates complement system through lectin pathway in innate immunity against the host's infection. Conflictingly, a number of MBL2 variants, rs1800450 (A>B), rs1800451 (A>C), rs5030737 (A>D), rs7096206 (Y>X), rs11003125 (H>L), and rs7095891 (P>Q) allele, have been found to be associated with compromised serum levels and pulmonary tuberculosis (PTB) susceptibility. The present meta-analysis study was performed to evaluate the potential association of these MBL2 gene variants with PTB susceptibility. Read More

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https://www.dovepress.com/association-of-mbl2-gene-polymorph
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http://dx.doi.org/10.2147/IDR.S188980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333159PMC
January 2019
6 Reads

Erratum: Detection and characterization of a clinical ST3204 strain coproducing NDM-16 and MCR-1 [Corrigendum].

Authors:

Infect Drug Resist 2019 8;12:183-184. Epub 2019 Jan 8.

[This corrects the article on p. 1189 in vol. 11, PMID: 30147347. Read More

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http://dx.doi.org/10.2147/IDR.S193782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329478PMC
January 2019
1 Read