568 results match your criteria Infection and Drug Resistance [Journal]


Alternative eradication regimens for infection in Indonesian regions with high metronidazole and levofloxacin resistance.

Infect Drug Resist 2019 31;12:345-358. Epub 2019 Jan 31.

Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan,

Background: The prevalence of resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens.

Methods: We determined the minimum inhibitory concentrations (MICs) of five alternative antibiotics for (rifaximin, rifabutin, furazolidone, garenoxacin, and sitafloxacin) using the agar dilution method and assessed mutations associated with antibiotic resistance using next-generation sequencing. Read More

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http://dx.doi.org/10.2147/IDR.S187063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362932PMC
January 2019

The impact of initial antibiotic treatment failure: real-world insights in patients with complicated, health care-associated intra-abdominal infection.

Infect Drug Resist 2019 31;12:329-343. Epub 2019 Jan 31.

Department of Medicine, Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena - Instituto de Biomedicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain,

Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation of antibiotic therapy) for health care-associated infections across five countries.

Patients And Methods: Data were collected from a retrospective chart review of patients aged ≥18 years with health care-associated complicated intra-abdominal infection (cIAI). Potential risk factors for IAT failure were identified using logistic regression analyses. Read More

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http://dx.doi.org/10.2147/IDR.S184116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362915PMC
January 2019

Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis.

Infect Drug Resist 2019 29;12:311-319. Epub 2019 Jan 29.

Community and Occupational Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt,

Background: Neonatal sepsis (NS) is an important cause of morbidity and mortality among newborns. Its diagnosis depends mainly on blood culture that takes at least 48 hours to give results. Therefore, searching for biomarkers for early diagnosis is of value. Read More

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http://dx.doi.org/10.2147/IDR.S191533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357881PMC
January 2019

Platelet-rich plasma plays an antibacterial, anti-inflammatory and cell proliferation-promoting role in an in vitro model for diabetic infected wounds.

Infect Drug Resist 2019 29;12:297-309. Epub 2019 Jan 29.

Department of Endocrinology, Southwest Hospital, Army Medical University, Chongqing, People's Republic of China,

Aim: This study was designed to examine the potential mechanism underlying these roles of platelet-rich plasma in treating diabetic foot ulcers (DFUs).

Methods: and HaCaT were co-cultured under high glucose conditions to serve as an in vitro model for infected cells in DFUs. Platelet-rich gel (PRG) or extract liquid of platelet-rich gel (EPG) were used to interfere with the model to observe the growth of HaCaT cells and , and the effect of miR-21 changes in HaCaT cells on PDCD4, NF-κB activity and related inflammatory factors. Read More

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http://dx.doi.org/10.2147/IDR.S186651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357877PMC
January 2019
2 Reads

Comparative analysis of KPC-2-encoding chimera plasmids with multi-replicon IncR:Inc:IncN1 or IncFII:Inc:IncN1.

Infect Drug Resist 2019 24;12:285-296. Epub 2019 Jan 24.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China,

Background: IncR, IncFII, IncpA1763-KPC, and IncN1 plasmids have been increasingly found among species, but plasmids with hybrid structures derived from the above-mentioned incompatibility groups have not yet been described.

Methods: Plasmids p721005-KPC, p504051-KPC, and pA3295-KPC were fully sequenced and compared with previously sequenced related plasmids pHN84KPC (IncR), pKPHS2 (IncFII), pKOX_NDM1 (IncFII), pHN7A8 (IncFII), and R46 (IncN1).

Results: The backbone of p721005-KPC/p504051-KPC was a hybrid of the entire 10-kb IncR-type backbone from pHN84KPC, the entire 64. Read More

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http://dx.doi.org/10.2147/IDR.S189168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353027PMC
January 2019

Selection between aztreonam and cephalosporins for treatment of infections with pseudomonads needs more caution.

Authors:
Bhoj R Singh

Infect Drug Resist 2019 24;12:281-284. Epub 2019 Jan 24.

Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, India,

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http://dx.doi.org/10.2147/IDR.S193132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353025PMC
January 2019

Prevalence and predictors of occult hepatitis C virus infection among Egyptian patients who achieved sustained virologic response to sofosbuvir/daclatasvir therapy: a multi-center study.

Infect Drug Resist 2019 22;12:273-279. Epub 2019 Jan 22.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt,

Background: Occult hepatitis C virus (HCV) infection (OCI) is characterized by the detection of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) and/or hepatocytes with undetectable HCV-RNA or antibodies in the serum. In this study, we tried to evaluate the prevalence and possible predictors of OCI in patients who achieved sustained virologic response (SVR) post sofosbuvir/daclatasvir (SOF/DCV) therapy.

Patients And Methods: A cross-sectional multicenter study was designed to enroll 1,280 HCV-infected patients who received SOF (400 mg) plus DCV (60 mg) once daily ± ribavirin regimen for 12 weeks and achieved SVR 12 weeks post treatment. Read More

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http://dx.doi.org/10.2147/IDR.S181638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348965PMC
January 2019

Central nervous system infection mimicking central nervous system idiopathic inflammatory demyelinating disease.

Infect Drug Resist 2019 22;12:255-259. Epub 2019 Jan 22.

Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China,

(Lm) is an opportunistic pathogen that causes life-threatening infections, especially when the central nervous system (CNS) is involved. Here, we report a patient who was admitted to the hospital with headache, dizziness, right side facial numbness, and hoarseness. The individual was initially diagnosed with central nervous system idiopathic inflammatory demyelinating disease (CNS IIDD), which was then found to be CNS Lm infection (brainstem and cervical cord infection). Read More

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http://dx.doi.org/10.2147/IDR.S189930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348973PMC
January 2019

Prevalence and antimicrobial resistance of species isolated from diarrheal patients in Ahvaz, southwest Iran.

Infect Drug Resist 2019 22;12:249-253. Epub 2019 Jan 22.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Introduction: Shigellosis is a significant global human health problem, and is in charge of almost 165 million cases of this disease annually, of whom 163 million cases are in developing countries and 1.5 million cases are in developed countries. The main aims of the current survey were to identify spp. Read More

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http://dx.doi.org/10.2147/IDR.S187861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348961PMC
January 2019

Treatment of severe ventriculitis caused by extensively drug-resistant by intraventricular lavage and administration of colistin.

Infect Drug Resist 2019 21;12:241-247. Epub 2019 Jan 21.

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China,

Background: Severe ventriculitis (SV) caused by multidrug-resistant bacteria is associated with high morbidity and mortality in neurosurgical patients. This study assessed the outcomes of patients with SV caused by who were treated by intraventricular (IVT) lavage and colistin administration.

Methods: This retrospective study included consecutive patients with SV caused by who were admitted at the Neurosurgical Department of Shanghai Tenth People's Hospital from January 2014 to September 2017. Read More

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http://dx.doi.org/10.2147/IDR.S186646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345184PMC
January 2019
1 Read

Resistance rates of non- infections in Taiwan after the revision of 2012 Clinical and Laboratory Standards Institute breakpoints.

Infect Drug Resist 2019 15;12:235-240. Epub 2019 Jan 15.

Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan,

Purpose: In 2012, the Clinical and Laboratory Standards Institute (CLSI) revised its breakpoints for drugs and species because of the increase in non- infections and their drug resistance. Following global trends, the non- candidemia resistance rate has increased in Taiwan as well. To update the antifungal susceptibility of non- candidemia isolates, we conducted a multicenter study using the revised break points. Read More

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http://dx.doi.org/10.2147/IDR.S184884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338119PMC
January 2019
1 Read

Gene drives as a response to infection and resistance.

Infect Drug Resist 2019 14;12:229-234. Epub 2019 Jan 14.

Department of Healthcare Administration, Sawyer Business School, Suffolk University, Boston, MA, USA,

Vector-borne infectious diseases continue to be a major threat to public health. Although some prevention and treatment modalities exist for these diseases, resistance to such modalities, exacerbated by global climate change, remains a fundamental challenge. Developments in genomic engineering technologies present a new front in battling vector-borne illnesses; however, there is a lack of consensus over the scope and consequences of these approaches. Read More

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http://dx.doi.org/10.2147/IDR.S187424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336018PMC
January 2019

Molecular characterization of the gene and its association with the frequency of plasmid pKLC102 and PAPI-1 pathogenicity island.

Infect Drug Resist 2019 11;12:221-227. Epub 2019 Jan 11.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: is the most common opportunistic pathogen associated with a broad range of infections, including cystic fibrosis, ocular, otitis media, and burn infections. The aim of this study was to show the frequency of the gene, and its association with plasmid pKLC102 and PAPI-1 pathogenicity island among strains.

Methods: The samples were collected from patients with cystic fibrosis, ocular, otitis media, and burn infections between January 2016 and November 2017. Read More

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https://www.dovepress.com/molecular-characterization-of-the-
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http://dx.doi.org/10.2147/IDR.S188527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333160PMC
January 2019
3 Reads

Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China.

Infect Drug Resist 2019 10;12:211-219. Epub 2019 Jan 10.

Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563003, China,

Objectives: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-TB burden and resource-limited province of China. Read More

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http://dx.doi.org/10.2147/IDR.S188538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330984PMC
January 2019

Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.

Infect Drug Resist 2019 11;12:185-210. Epub 2019 Jan 11.

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia,

Background: Mannose-binding lectin (MBL) or mannose-binding protein (MBP), encoded by MBL2 gene and secreted by the liver, activates complement system through lectin pathway in innate immunity against the host's infection. Conflictingly, a number of MBL2 variants, rs1800450 (A>B), rs1800451 (A>C), rs5030737 (A>D), rs7096206 (Y>X), rs11003125 (H>L), and rs7095891 (P>Q) allele, have been found to be associated with compromised serum levels and pulmonary tuberculosis (PTB) susceptibility. The present meta-analysis study was performed to evaluate the potential association of these MBL2 gene variants with PTB susceptibility. Read More

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https://www.dovepress.com/association-of-mbl2-gene-polymorph
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http://dx.doi.org/10.2147/IDR.S188980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333159PMC
January 2019
3 Reads

Erratum: Detection and characterization of a clinical ST3204 strain coproducing NDM-16 and MCR-1 [Corrigendum].

Authors:

Infect Drug Resist 2019 8;12:183-184. Epub 2019 Jan 8.

[This corrects the article on p. 1189 in vol. 11, PMID: 30147347. Read More

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http://dx.doi.org/10.2147/IDR.S193782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329478PMC
January 2019

Oral sitafloxacin vs intravenous ceftriaxone followed by oral cefdinir for acute pyelonephritis and complicated urinary tract infection: a randomized controlled trial.

Infect Drug Resist 2019 8;12:173-181. Epub 2019 Jan 8.

Department of Surgery, Maharaj Nakorn Si Thammarat Hospital, Nakhon Si Thammarat, Thailand.

Background: The conventional antibiotic regimen for community-acquired upper urinary tract infections with moderate severity in Thailand is parenteral ceftriaxone (CTRX) for several days followed by oral cephalosporin for 7-14 days. The aim of this study was to compare the efficacy and safety of oral sitafloxacin (STFX) with that of intravenous CTRX followed by oral cefdinir (CFDN) for the therapy of acute pyelonephritis (APN) and complicated urinary tract infection (cUTI).

Methods: This open-label, randomized, controlled, noninferiority clinical trial included patients from nine centers across Thailand. Read More

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http://dx.doi.org/10.2147/IDR.S178183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329481PMC
January 2019
1 Read

Molecular epidemiology and clinical significance of isolated from clinical specimens.

Infect Drug Resist 2019 4;12:161-171. Epub 2019 Jan 4.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea,

Purpose: This study investigated the clinical epidemiology, antimicrobial susceptibility, and molecular epidemiology of isolates.

Patients And Methods: An observational study was conducted at a university hospital in the Republic of Korea from August to December 2016. All subjects were patients who tested positive for clinically. Read More

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https://www.dovepress.com/molecular-epidemiology-and-clinica
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http://dx.doi.org/10.2147/IDR.S184518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324608PMC
January 2019
3 Reads

Virulence and genomic features of a and coharboring hypermucoviscous of serotype K2 and ST65.

Infect Drug Resist 2019 3;12:145-159. Epub 2019 Jan 3.

Department of Respiratory Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China,

Background: Capsular serotype K2 of sequence type (ST) 65 has been recognized as a hypervirulent clone. Simultaneous presence of different genes has never been reported in this clone. In the present study, the genetic characteristics and virulence phenotype of a CTX-M-3 and CTX-M-14 coproducing ST65 human isolate, KP_06, that caused an intracranial infection, are evaluated. Read More

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http://dx.doi.org/10.2147/IDR.S187289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322562PMC
January 2019

Phenotypic and genotypic determinants of mupirocin resistance among isolates recovered from clinical samples of children: an Iranian hospital-based study.

Infect Drug Resist 2019 3;12:137-143. Epub 2019 Jan 3.

Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran,

Backgrounds: The aim of this study was to evaluate both phenotypic and genotypic determinants of mupirocin resistance among methicillin-resistant (MRSA) and methicillin susceptible (MSSA) strains recovered from different clinical samples of children who were admitted to the Children's Medical Center (CMC) Hospital, Tehran, Iran.

Materials And Methods: A total of 120 clinical isolates of were collected from the microbiology laboratory of CMC Hospital. Antimicrobial susceptibility of the isolates to different antimicrobial agents was determined by disk diffusion method. Read More

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http://dx.doi.org/10.2147/IDR.S185610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322560PMC
January 2019

In vitro activity of colistin in combination with various antimicrobials against species, a report from South Iran.

Infect Drug Resist 2019 31;12:129-135. Epub 2018 Dec 31.

Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran,

Introduction: is a gram-negative,opportunistic pathogen responsible for resistant nosocomial infections especially in the intensive care units (ICUS).One reason for the failure in the treatment of is its ability of develop resistance against several antimicrobials. combination of different antimicrobials can be used to overcome such a resistance. Read More

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https://www.dovepress.com/in-vitro-activity-of-colistin-in-c
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http://dx.doi.org/10.2147/IDR.S182585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318711PMC
December 2018
4 Reads

Molecular epidemiology of ESBL-producing and : establishing virulence clusters.

Infect Drug Resist 2019 31;12:119-127. Epub 2018 Dec 31.

INSERM, Sorbonne Université, Institut Pierre Louis d'Épidémiologie et de Santé Publique, Paris, France.

Objective: To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing and and assess whether these clusters are associated with genetic determinants or clinical outcomes.

Methods: One hundred forty-eight and 82 . clinical isolates were obtained from 213 patients in Paris, France. Read More

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http://dx.doi.org/10.2147/IDR.S179134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318714PMC
December 2018

Outpatient ertapenem therapy in an ESBL-high-prevalence area: an efficacy, safety, and cost study.

Infect Drug Resist 2019 28;12:111-117. Epub 2018 Dec 28.

Department of Infectious Disease, Hospital General Dr. Manuel GEA González, Mexico City, Mexico,

Introduction: Outpatient parenteral antimicrobial therapy is a safe, effective, and convenient way of administering antimicrobials for a wide variety of infections. So far there are no reports on the efficacy of outpatient antimicrobial therapy in Mexico. Our objective was to determine the outcomes, safety, and cost of outpatient ertapenem therapy (OET) in our hospital. Read More

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http://dx.doi.org/10.2147/IDR.S173468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312697PMC
December 2018
4 Reads

Prevalence and molecular characteristics of gene in in a tertiary hospital of Zhejiang Province.

Infect Drug Resist 2019 28;12:105-110. Epub 2018 Dec 28.

Department of Laboratory, Quzhou People's Hospital, Quzhou, Zhejiang, China,

Objectives: gene has been widely reported in the world. This study aimed to analyze the prevalence and molecular characteristics of gene in from Quzhou People's Hospital.

Materials And Methods: A total of 62 isolates were isolated and preserved in our laboratory from 2007 to 2016. Read More

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http://dx.doi.org/10.2147/IDR.S190269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312689PMC
December 2018
2 Reads

Evaluation of the accuracy of molecular assays targeting the mutation A2059G for detecting high-level azithromycin resistance in : a systematic review and meta-analysis.

Infect Drug Resist 2019 28;12:95-104. Epub 2018 Dec 28.

Department of Reference STD Lab, National Center for STD Control, Chinese Center for Disease Control and Prevention, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China,

Background: resistance to azithromycin has become a significant public health concern globally, and high-level azithromycin-resistant (HL-AzmR) isolates have emerged frequently. However, high-level azithromycin resistance is considered to be caused by mutated alleles of 23S rRNA gene at position 2059, and identification of HL-AzmR isolates mainly relies on agar dilution method or E-test method. This study aimed to assess the accuracy of the molecular assays targeting the mutation A2059G for identifying HL-AzmR isolates and thereby determine the association between the mutation and high-level azithromycin resistance. Read More

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https://www.dovepress.com/evaluation-of-the-accuracy-of-mole
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http://dx.doi.org/10.2147/IDR.S183754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312691PMC
December 2018
4 Reads

Additional benefits of GeneXpert MTB/RIF assay for the detection of pulmonary tuberculosis patients with prior exposure to fluoroquinolones.

Infect Drug Resist 2019 27;12:87-93. Epub 2018 Dec 27.

Department of Tuberculosis, The Fifth People's Hospital of Suzhou, Suzhou, China,

Background: We performed a prospective study to investigate the association between pre-diagnosis exposure to fluoroquinolone (FQ) and laboratory testing results among tuberculosis (TB) patients.

Patients And Methods: Each TB-suspected patient provided sputum specimen for mycobacteria growth indicator tube (MGIT) culture and GeneXpert among pulmonary TB patients. Confirmed TB patients and clinically diagnosed TB patients were further enrolled in the final analysis. Read More

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http://dx.doi.org/10.2147/IDR.S181259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314046PMC
December 2018

Silencing of unveils the role of -linked glycans during the host-fungus interaction.

Infect Drug Resist 2019 28;12:67-85. Epub 2018 Dec 28.

Department of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico,

Background: is a neglected fungal pathogen for the human being and other mammals. In several fungal systems, Och1 is a Golgi α1,6-mannosyltransferase with a key function in the synthesis of -linked glycans; which are important elements during the host-fungus interplay. The role of in fungal virulence seems to be species-specific, being an essential component for virulence and dispensable during the interaction of with the host. Read More

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http://dx.doi.org/10.2147/IDR.S185037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312695PMC
December 2018
1 Read

Rotavirus infection beyond the gut.

Infect Drug Resist 2019 24;12:55-64. Epub 2018 Dec 24.

Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Galicia, Spain,

The landscape of rotavirus (RV) infection has changed substantially in recent years. Autoimmune triggering has been added to clinical spectrum of this pathology, which is now known to be much broader than diarrhea. The impact of RV vaccines in these other conditions is becoming a growing field of research. Read More

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https://www.dovepress.com/rotavirus-infection-beyond-the-gut
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http://dx.doi.org/10.2147/IDR.S186404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307677PMC
December 2018
5 Reads

Endemic dissemination of different sequence types of carbapenem-resistant strains harboring and genes in Kerman hospitals, Iran, from 2015 to 2017.

Infect Drug Resist 2019 21;12:45-54. Epub 2018 Dec 21.

Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran,

Introduction: The emergence and spread of strains resistant to multiple antimicrobial agents are considered as a serious challenge for nosocomial infections.

Materials And Methods: In this study, 175 nonrepetitive clinical isolates of were collected from hospitalized patients in Kerman, Iran. Extended-spectrum β-lactamases (ESBLs), AmpC, and carbapenemase-producing isolates were recognized by phenotypic methods. Read More

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https://www.dovepress.com/endemic-dissemination-of-different
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http://dx.doi.org/10.2147/IDR.S186994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306073PMC
December 2018
4 Reads

Detection of in patients with leprosy in India [Retraction].

Authors:

Infect Drug Resist 2019 21;12:31. Epub 2018 Dec 21.

[This retracts the article on p. 1677 in vol. 11, PMID: 30349325. Read More

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http://dx.doi.org/10.2147/IDR.S198258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306048PMC
December 2018

Emergence and molecular characterization of multidrug-resistant isolates harboring extended-spectrum β-lactamases causing ventilator-associated pneumonia in China.

Infect Drug Resist 2019 20;12:33-43. Epub 2018 Dec 20.

Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China,

Background: Ventilator-associated pneumonia (VAP) is a common nosocomial infection associated with high morbidity due to multidrug-resistant (MDR) pathogens. The purpose of this study was to determine the occurrence of extended-spectrum β-lactamase (ESBL) genes, especially , in ()-associated VAP and to investigate the antimicrobial resistance patterns and molecular epidemiological characteristics of strains.

Materials And Methods: From January 2013 to December 2015, we retrospectively collected 89 VAP-causing isolates from tertiary-care hospitals in China, among which ESBL-producing strains were assessed for antimicrobial susceptibility. Read More

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https://www.dovepress.com/emergence-and-molecular-characteri
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http://dx.doi.org/10.2147/IDR.S189494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304254PMC
December 2018
7 Reads

In vitro activity of cefoperazone and cefoperazone-sulbactam against carbapenem-resistant and .

Infect Drug Resist 2019 20;12:25-29. Epub 2018 Dec 20.

Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan,

Background: This study aimed to investigate the in vitro activity of cefoperazone-sulbactam against carbapenem-resistant and , and to evaluate the antibiotic resistance mechanisms of these bacteria.

Materials And Methods: In total, 21 isolates of carbapenem-resistant and 15 isolates of carbapenem-resistant with different pulsed-field gel electrophoresis types were collected for assessment of the in vitro antibacterial activities of cefoperazone and cefoperazone-sulbactam and the associated resistance mechanisms of the bacteria.

Results: For carbapenem-resistant , the minimum inhibitory concentration (MIC) value and antibiotic susceptibility rate were similar for cefoperazone and cefoperazone-sulbactam (at 1:1 and 2:1 ratios). Read More

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http://dx.doi.org/10.2147/IDR.S181201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304247PMC
December 2018

Performance evaluation of the (1,3)-β-D-glucan detection assay in non-intensive care unit adult patients.

Infect Drug Resist 2019 20;12:19-24. Epub 2018 Dec 20.

Institute of Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy,

Objectives: To assess the performance of the (1,3)-β-D-glucan (BDG) detection assay in a large cohort of patients with suspected candidemia who were admitted to non-intensive care unit hospital wards.

Methods: This observational, retrospective cohort study was conducted in a 1,100-bed university hospital in Rome, where an infectious disease consultation team has been operational. Two groups of patients were included in the analysis: Group 1, patients with bloodstream infection (BSI) who had at least one BDG test performed ±48 hours from the first positive blood culture ( BSI Group) and Group 2, patients with risk factors for candidemia who had at least one BDG test but had negative blood cultures (Control Group). Read More

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https://www.dovepress.com/performance-evaluation-of-the-13-b
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http://dx.doi.org/10.2147/IDR.S181489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304239PMC
December 2018
1 Read

Prevalence and phenotypic characterization of carbapenem-resistant strains recovered from sputum and fecal samples of ICU patients in Zhejiang Province, China.

Infect Drug Resist 2019 18;12:11-18. Epub 2018 Dec 18.

Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China,

Objective: To understand the prevalence and transmission of carbapenem-resistant (CRKP) in ICU patients in Zhejiang Province, China, and determined the genetic and phenotypic characteristics of these CRKP strains.

Materials And Methods: A total of 202 ICU patients from eight tertiary hospitals were recruited and 55 non-duplicate CRKP strains were collected during July and August in 2017. These strains were subjected to determination of MICs, carriage of carbapenemase genes and variants, PFGE, MLST and virulence potential using larvae infection model. Read More

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http://dx.doi.org/10.2147/IDR.S175823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302810PMC
December 2018

Bezlotoxumab for the prevention of infection: a review of current evidence and safety profile.

Infect Drug Resist 2019 17;12:1-9. Epub 2018 Dec 17.

Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA.

infection (CDI) is a leading nosocomial disease estimated to cause nearly half a million cases in the United States annually. Recurrent CDI (rCDI) affects ~25% of patients after completion of standard of care therapy and is associated with substantial health care costs and a negative impact on patient's overall markers of quality of life. Bezlotoxumab is the first of its kind monoclonal antibody directed against toxin B and indicated for prevention of rCDI in at-risk patients. Read More

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https://www.dovepress.com/bezlotoxumab-for-the-prevention-of
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http://dx.doi.org/10.2147/IDR.S159957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301304PMC
December 2018
7 Reads

Community-acquired methicillin-resistant from ST1 lineage harboring a new SCC IV subtype (SCC IVm) containing the gene.

Infect Drug Resist 2018 14;11:2583-2592. Epub 2018 Dec 14.

Laboratory of Molecular Biology of Bateria, Department of Medical Microbiology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil,

A pivotal event in the evolutionary path of methicillin-resistant (MRSA) is the acquisition of the staphylococcal cassette chromosome (SCC) element carrying the gene, the determinant of methicillin resistance. Community-acquired (CA) MRSA is commonly associated with skin/soft tissue infections, and doxycycline is one of the drug choices for this purpose. Doxycycline resistance is associated with the acquisition of the gene carried by the plasmid pT181, which may also be integrated into SCC III and V. Read More

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http://dx.doi.org/10.2147/IDR.S175079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299468PMC
December 2018

Risk factors and prognosis of complicated urinary tract infections caused by in hospitalized patients: a retrospective multicenter cohort study.

Infect Drug Resist 2018 18;11:2571-2581. Epub 2018 Dec 18.

Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Spanish Network for Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III (ISCIII), Madrid, Spain,

Purpose: Complicated urinary tract infections (cUTIs) are among the most frequent health-care-associated infections. In patients with cUTI, deserves special attention, since it can affect patients with serious underlying conditions. Our aim was to gain insight into the risk factors and prognosis of cUTIs in a scenario of increasing multidrug resistance (MDR). Read More

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http://dx.doi.org/10.2147/IDR.S185753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302800PMC
December 2018

Genotyping and antibiotic resistance properties of strains isolated from human and animal gastric biopsies.

Infect Drug Resist 2018 13;11:2545-2554. Epub 2018 Dec 13.

Biotechnology Research Center, Shahr-e Kord Branch, Islamic Azad University, Shahr-e Kord, Iran.

Purpose: The present study was done to assess the prevalence rate, antibiotic resistance pattern and genotyping status of the strains isolated from human and animal gastric biopsy samples.

Patients And Methods: A total of 1,150 gastric biopsy samples were randomly collected from humans (children and adults) and animals (cows, sheep and goats). All samples were subjected to culture, urease test and histopathologic examination. Read More

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http://dx.doi.org/10.2147/IDR.S187885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296207PMC
December 2018
2 Reads

Vancomycin in the treatment of adult intra-abdominal infections: do we have strong evidences?

Infect Drug Resist 2018 7;11:2539-2543. Epub 2018 Dec 7.

Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China,

The management of intra-abdominal infections (IAIs) primarily includes adequate antimicrobial therapy and appropriate source control. Vancomycin is a fundamental and most effective antimicrobial agent. The aim of this study is to search and evaluate the quality of clinical evidences regarding the exclusive use of vancomycin for the management of adult IAIs. Read More

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https://www.dovepress.com/vancomycin-in-the-treatment-of-adu
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http://dx.doi.org/10.2147/IDR.S185331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290861PMC
December 2018
8 Reads

The association between platelet indices and deep surgical site infection after open induction internal fixation for traumatic limb fractures.

Infect Drug Resist 2018 6;11:2533-2538. Epub 2018 Dec 6.

Department of Orthopedics, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China,

Objectives: Deep surgical site infection (DSSI) is one of the most serious complications after open induction internal fixation (ORIF) for traumatic limb fractures. In this study, we aimed to investigate the diagnostic role of platelet indices (platelet count [PLT], mean platelet volume [MPV], and platelet distribution width [PDW]) in DSSI.

Patients And Methods: Data obtained between January 2011 and December 2017 in The Affiliated Drum Tower Hospital of Nanjing University Medical School from cases (n=29) with DSSI and fracture control subjects (n=29) matched for age, gender, and fracture type were analyzed. Read More

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http://dx.doi.org/10.2147/IDR.S184877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287519PMC
December 2018

Infection control perception and behavior: a question of sex and gender? Results of the AHOI feasibility study.

Infect Drug Resist 2018 4;11:2511-2519. Epub 2018 Dec 4.

Institute of Hygiene and Environmental Medicine, Universitätsmedizin Greifswald, Greifswald, Germany,

Purpose: Infections, in particular with multidrug-resistant organisms, are a burden for inpatient and outpatient care and the whole community. The pathogens "roam" with patients and their relatives, forming an epidemiological bridge between different care facilities. Patients could play an important role in infection control, given that they are properly involved. Read More

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http://dx.doi.org/10.2147/IDR.S178922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287514PMC
December 2018

An increasing trend of neonatal invasive multidrug-resistant group B streptococcus infections in southern China, 2011-2017.

Infect Drug Resist 2018 10;11:2561-2569. Epub 2018 Dec 10.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China,

Background: A multidrug-resistant (MDR) RR2 gene cluster was identified by whole-genome sequencing in several highly virulent (ST-17) Group B streptococcus (GBS) isolates, which caused neonatal invasive infections in southern China in 2016. Tracing the transmission and distribution of MDR isolates in this area is important for the effective management of future infections. The aim of this study was to obtain longitudinal data of MDR isolates to monitor epidemiological trends of general common isolates in southern China, and provide evidence for future characterization of antimicrobial resistance mechanisms. Read More

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http://dx.doi.org/10.2147/IDR.S178717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292236PMC
December 2018
1 Read

Simultaneous three Enterobacteriaceae with different -encoding plasmids in a patient transferred from mainland China to Taiwan.

Infect Drug Resist 2018 7;11:2555-2560. Epub 2018 Dec 7.

Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan,

New-Delhi metallo-β-lactamase1 (NDM-1) are increasing worldwide. Herein, we describe a single patient who carried three unusual NDM-1 carbapenem-resistant yielded from a urine specimen and and from stool specimens. For , its NDM-1-encoding plasmid was pKP04NDM with a size of ~54 kb replicons with an IncN backbone. Read More

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http://dx.doi.org/10.2147/IDR.S179024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290869PMC
December 2018

Prevalence of nontuberculous mycobacteria and high efficacy of d-cycloserine and its synergistic effect with clarithromycin against and .

Infect Drug Resist 2018 7;11:2521-2532. Epub 2018 Dec 7.

Tuberculosis Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: The prevalence of pulmonary disease caused by nontuberculous mycobacteria (NTM) is reportedly on the rise in the world. Some of the species are resistant to various antibiotics; hence, limited treatment options are available. The aims of this study were to investigate the prevalence of NTM and to determine the effect of d-cycloserine against and isolated from clinical specimens to find out the synergistic effect of d-cycloserine and clarithromycin. Read More

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http://dx.doi.org/10.2147/IDR.S187554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290872PMC
December 2018
1 Read

Relation between flomoxef minimum inhibitory concentrations and clinical outcomes of patients treated with flomoxef for Enterobacteriaceae bacteremia.

Infect Drug Resist 2018 27;11:2471-2480. Epub 2018 Nov 27.

Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal breakpoints based on the survival of patients with Enterobacteriaceae BSIs treated with flomoxef.

Methods: The 30-day crude mortality rate was analyzed among 224 adults who initiated flomoxef monotherapy for Enterobacteriaceae BSIs at a medical center over a 3-year period, according to the flomoxef MICs of the initial isolates. Read More

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https://www.dovepress.com/relation-between-flomoxef-minimum-
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http://dx.doi.org/10.2147/IDR.S185670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267728PMC
November 2018
1 Read

Fecal carriage and phylodiversity of community-acquired Enteric bacilli in Southwest Nigeria.

Infect Drug Resist 2018 27;11:2425-2433. Epub 2018 Nov 27.

Microbiology Unit, Department of Biological Sciences, Covenant University, Otta, Nigeria,

Purpose: Increasing rates of clonal spread of fecal bacilli remains a huge concern to the community health with resultant high morbidity. The fecal carriage and clonal diversity of within the communities in Southwest Nigeria were surveyed.

Materials And Methods: Enteric bacilli obtained from fresh fecal samples randomly collected from community residents were biotyped and profiled for antibiotic susceptibility. Read More

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http://dx.doi.org/10.2147/IDR.S178243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267359PMC
November 2018

Methicillin-resistant : livestock-associated, antimicrobial, and heavy metal resistance.

Infect Drug Resist 2018 28;11:2497-2509. Epub 2018 Nov 28.

Microbiology and Virology Research Group, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa,

is an opportunistic pathogen of human and other mammals that is of increasing clinical and veterinary importance due to its ability to rapidly develop antimicrobial resistance. The injudicious use of antibiotics has given rise to the emergence of antibiotic resistant strains, most importantly methicillin-resistant (MRSA). The emergence of livestock-associated MRSA (LA-MRSA) has highlighted the importance of directed research toward its prevention, as well as the need for the discovery and development of more efficient treatment than is currently available. Read More

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https://www.dovepress.com/methicillin-resistant-staphylococc
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http://dx.doi.org/10.2147/IDR.S175967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278885PMC
November 2018
7 Reads

Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing serovar Typhimurium isolated from a case of fatal burn wound infection.

Infect Drug Resist 2018 28;11:2491-2495. Epub 2018 Nov 28.

Department of Medical Microbiology and Immunology, RAK College of Medical Sciences, RAK Medical and Health Sciences University (RAKMHSU), Ras Al Khaimah, UAE,

species are frequently associated with gastrointestinal infections such as diarrhea. However, extraintestinal infections, including burn infections, have been described. Here, we report the first case of a carbapenem-resistant and metallo-β-lactamase (New Delhi metallo-β-lactamase), extended-spectrum β-lactamase (SHV-12), and AmpC β-lactamase (CMY-4) coproducing Typhimurium isolated from a fatal case of burn wound infection. Read More

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https://www.dovepress.com/whole-genome-sequence-analysis-of-
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http://dx.doi.org/10.2147/IDR.S167027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278884PMC
November 2018
9 Reads

The performance of serum cryptococcal capsular polysaccharide antigen test, histopathology and culture of the lung tissue for diagnosis of pulmonary cryptococcosis in patients without HIV infection.

Infect Drug Resist 2018 28;11:2483-2490. Epub 2018 Nov 28.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China,

Background: Clinicians may fail to make an early diagnosis of pulmonary cryptococcosis (PC) without HIV infection. Serum cryptococcal capsular polysaccharide antigen (CrAg) test, histopathology and culture of lung tissue play different roles in diagnosis of PC.

Objective: To investigate the performance of serum CrAg test, histopathology and culture of the lung tissue in diagnosis of PC without HIV infection. Read More

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http://dx.doi.org/10.2147/IDR.S178391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278883PMC
November 2018
2 Reads