1,587,027 results match your criteria Infection Genetics and Evolution [Journal]


Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.

Yonsei Med J 2019 Jan;60(1):10-21

Division of Rheumatology, Department of Internal Medicine, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Conference Nomenclature of Vasculitides proposed in 2012 have encouraged physicians to classify AAV patients properly. Read More

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January 2019

Genomic sequence capture of haemosporidian parasites: Methods and prospects for enhanced study of host-parasite evolution.

Mol Ecol Resour 2018 Dec 16. Epub 2018 Dec 16.

Museum of Southwestern Biology and Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, New Mexico, 87131-0001, USA.

Avian malaria and related haemosporidians (Plasmodium, [Para]Haemoproteus, and Leucocytoozoon) represent an exciting multi-host, multi-parasite system in ecology and evolution. Global research in this field accelerated after 1) the publication in 2000 of PCR protocols to sequence a haemosporidian mitochondrial (mtDNA) barcode, and 2) the development in 2009 of an open-access database to document the geographic and host ranges of parasite mtDNA haplotypes. Isolating haemosporidian nuclear DNA from bird hosts, however, has been technically challenging, slowing the transition to genomic-scale sequencing techniques. Read More

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December 2018

Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa).

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan, 611130, China.

Elizabethkingia miricola is a Gram-negative rod which has been incriminated in severe infections in humans. Recently, a serious infectious disease was identified in Chinese spiny frogs (Quasipaa spinosa), in the Sichuan Province of China; the disease was characterized by corneal opacity, the presence of ascites, and neurologic symptoms. A Gram-negative bacillus was isolated from the liver, spleen, and kidney of the diseased frogs. Read More

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December 2018

Hepatitis c late relapse in patients with directly acting antiviral- related sustained virological response at week 12.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Laboratory for the identification of prognostic factors of response to the treatment against infectious diseases, University of Campania, Naples, Italy.

Aim: The aim of the present study was to identify, among the patients with failure to DAA regimen, those with a late relapse (after the achievement of a sustained virological response at week 12) and to characterize the clinical, epidemiological and virological features of these patients.

Material And Methods: 129 HCV patients with non-response to an IFN-free regimen were enrolled. Sanger sequencing of NS3, NS5A and NS5B was performed at failure by home-made protocols. Read More

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December 2018

Orf virus infection of human keratinocytes and dermal fibroblasts: limited virus detection and interference with intercellular adhesion molecule-1 up-regulation.

Exp Dermatol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Orf virus (Parapoxvirus ovis, ORFV) is a dermatotropic virus causing pustular dermatitis in small ruminants and humans. We analyzed isolated human primary keratinocytes (KC) and dermal fibroblasts (FB) for cell death and virus replication by infection with a patient-derived ORFV isolate. ORFV infection was associated with rapid induction of cell death in KC allowing for considerable virus removal. Read More

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December 2018
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House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions.

Allergy 2018 Dec 16. Epub 2018 Dec 16.

Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, member of the German Center for Lung Research, 80802, Munich, Germany.

Background: Eicosanoid lipid mediators play key roles in type 2 immune responses, e.g. in allergy and asthma. Read More

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December 2018

Advances in understanding obligate biotrophy in rust fungi.

New Phytol 2018 Dec 16. Epub 2018 Dec 16.

UMR 1136 INRA/Université de Lorraine Interactions Arbres/Microorganismes, INRA Centre Grand Est - Nancy, 54280, Champenoux, France.

Rust fungi (Pucciniales) are the largest group of plant pathogens and represent one of the most devastating threats to agricultural crops worldwide. Despite the economic importance of these highly specialized pathogens, many aspects of their biology remain obscure largely because rust fungi are obligate biotrophs. The rise of genomics and advances in high-throughput sequencing technology have presented new options for identifying candidate effector genes involved in pathogenicity mechanisms of rust fungi. Read More

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December 2018

Is malnutrition associated with postoperative complications in patients with primary bone sarcomas?

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Modifiable risk factors that can be optimized to minimize postoperative complications in patients with bone sarcomas are yet to be identified.

Methods: We retrospectively identified 275 patients aged 18 and older who underwent surgery for primary bone sarcomas who also had albumin values recorded within 4 weeks before surgery. Postoperative complications were defined as infection, hematoma, need for additional surgery, or wound complications. Read More

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December 2018

Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.

Cell Mol Neurobiol 2018 Dec 15. Epub 2018 Dec 15.

State Key Laboratory Cultivation Base For TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.

Retinoic acid-induced 14 is a developmentally regulated gene induced by retinoic acid and is closely associated with NIK/NF-κB signaling. In the present study, we examined the effect of RAI14 on mTOR-mediated glial inflammation in response to inflammatory factors and chemical ischemia. A U87 cell model of LPS- and TNF-α-induced inflammation was used to investigate the role of RAI14 in glial inflammation. Read More

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December 2018

Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Oceanobacillus timonensis Marseille-P3532 (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587 (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. Read More

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December 2018

Illumina MiSeq Sequencing Investigation of Microbiota in Bronchoalveolar Lavage Fluid and Cecum of the Swine Infected with PRRSV.

Curr Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology, College of Life Science and Technology, Dalian University, Dalian, 116622, Liaoning, China.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide. In this study, we analyzed the microbiota in bronchoalveolar lavage fluid (BAL), mucosa, and feces in cecum of the PRRSV-challenged pigs using the Illumina MiSeq sequencing platform, to investigate the role of microbiota in the pathogenesis and development of porcine reproductive and respiratory syndrome (PRRS). Quantitative insights into microbial ecology analyses indicated that the dominant bacterial groups in the lung from the PRRSV-challenged pigs were Haemophilus parasuis and Mycoplasma hyorhinis, with a relative abundance of 35-48% and 27-41%, respectively. Read More

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December 2018

Parental awareness of newborn bloodspot screening in Ireland.

Ir J Med Sci 2018 Dec 15. Epub 2018 Dec 15.

Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation & Immunity (4i), University of Limerick, Limerick, Ireland.

Background: There is little known regarding how familiar parents are with the newborn bloodspot screening (NBS) test or how well parents of a child with a screen-detected condition understand that condition initially.

Aim: The study aim was to examine parental NBS awareness and conditions screened.

Methods: Two studies were conducted: [1] Parents of children with cystic fibrosis (CF) detected via NBS and subsequently, diagnosed (n = 124) completed a telephone questionnaire regarding information they received at the time of NBS. Read More

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December 2018

Translation of basic research in cognitive science to HIV-risk: a randomized controlled trial.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry and Behavioral Sciences, University of Washington, 1100 NE 45th Street, Suite 300, Box 354944, Seattle, WA, 98195-4944, USA.

Many people enrolled in drug diversion programs are not receiving evidence-based prevention for HIV or hepatitis. This study translated basic research from cognitive science to increase screening for infection and condom use in this population. A parallel three-condition randomized trial was conducted in a drug diversion sample (N = 358), comparing a memory practice condition with two active control conditions. Read More

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December 2018

Molecular Identification and Antifungal Susceptibility of Clinical Isolates of Sporothrix schenckii Complex in Medellin, Colombia.

Mycopathologia 2018 Dec 15. Epub 2018 Dec 15.

Grupo de Investigación Dermatológica, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-29, Oficina 303, Edificio Manuel Uribe Angel, Medellín, Colombia.

Background: Sporotrichosis is a subcutaneous mycosis that affects humans and other animals. Infection prevails in tropical and subtropical countries. Until a few years ago, it was considered that two varieties of Sporothrix schenckii caused this mycosis, but by applying molecular taxonomic markers, it has been demonstrated that there are several cryptic species within S. Read More

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December 2018

Interaction of H. pylori with toll-like receptor 2-196 to -174 ins/del polymorphism is associated with gastric cancer susceptibility in southern China.

Int J Clin Oncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.

Background: Genetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis.

Methods: This study included 520 people from southern China. Read More

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December 2018

Cranioplasties following craniectomies in children-a multicenter, retrospective cohort study.

Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurosurgery, Division of Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, room G03.124, 3484 CX, Utrecht, The Netherlands.

Objective: Complications following pediatric cranioplasty after craniectomy with either autologous bone flaps or cranial implants are reported to be common, particularly bone flap resorption. However, only sparse data are available regarding cranioplasty strategies, complications, and outcomes. This manuscript describes a Canadian-Dutch multicenter pediatric cohort study with autografts and cranial implant cranioplasties following craniectomies for a variety of indications. Read More

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December 2018

Effectiveness of an educational intervention on seasonal influenza vaccination campaign adherence among healthcare workers of the Palermo University Hospital, Italy.

Ann Ig 2019 Jan-Feb;31(1):35-44

Department of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, Italy.

Introduction: Healthcare workers are continuously exposed to the risk of being infected by influenza viruses during their work, thus representing a threat especially for fragile patients. Although the Italian Ministry of Health strongly recommends influenza vaccination for all HCWs, coverage levels in Italy are still far from the expected. Several studies report that one of the preferred strategies to improve vaccination coverage among Healthcare Workers is improving vaccination knowledge through specific multidisciplinary courses. Read More

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December 2018

Strategies to control antibiotic resistance: results from a survey in Italian children's hospitals.

Ann Ig 2019 Jan-Feb;31(1):3-12

Medical Direction, Bambino Gesù Children's Hospital, Rome, Italy.

Background: Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance.

Study Design: Cross sectional multicenter study. Read More

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December 2018

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2018 Dec 14;99(1):66-71. Epub 2018 Dec 14.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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December 2018

Topical vancomycin for neurosurgery wound prophylaxis: an interim report of a randomized clinical trial on drug safety in a diverse neurosurgical population.

Authors:

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

OBJECTIVEPostoperative surgical site infections (SSIs) in neurosurgical patients carry a significant risk of increased morbidity and mortality. With SSIs accounting for approximately 20% of nosocomial infections and costing approximately $1.6 billion USD annually, there is a need for additional prophylaxis to improve current standards of care. Read More

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December 2018
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Increasing proportion of herpes simplex virus type 1 among women and men diagnosed with first-episode anogenital herpes: a retrospective observational study over 14 years in Melbourne, Australia.

Sex Transm Infect 2018 Dec 15. Epub 2018 Dec 15.

Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.

Objectives: Reports of rising herpes simplex virus type 1 (HSV-1) genital infections relative to HSV-2 have been published up to 2006 in Australia. These changes have been attributed to declining childhood immunity to HSV-1. We described the temporal trends of HSV-1 and HSV-2 up to 2017 in Melbourne, Australia, to determine if the earlier trend is continuing. Read More

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December 2018

Lymphogranuloma venereum presenting as an ulcer on the tongue.

Sex Transm Infect 2018 Dec 15. Epub 2018 Dec 15.

Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain

Oropharyngeal lymphogranuloma venereum (LGV) is an uncommon presentation and mainly consists of either asymptomatic infections or enlarged cervical lymphadenopathy. According to cross-sectional studies, the prevalence of pharyngeal LGV among men who have sex with men (MSM) seems to be very low. Tissue tropism could explain the difference between rectal and oral mucosa infection frequencies. Read More

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December 2018

Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Eur J Med Chem 2018 Dec 7;163:560-568. Epub 2018 Dec 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated. Read More

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December 2018

Chlamydia trachomatis ct143 stimulates secretion of proinflammatory cytokines via activating the p38/MAPK signal pathway in THP-1 cells.

Mol Immunol 2018 Dec 13;105:233-239. Epub 2018 Dec 13.

Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, 410078, China.

Chlamydia trachomatis (Ct) infections can cause bacterial sexually-transmitted and preventable blindness. The Ct infections induced excessive cytokines generation which attributed to pathologic changes in host cells. However, the precise mechanisms of Ct-induced cytokines production are still unclear. Read More

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December 2018

White spot syndrome virus infection activates Caspase 1-mediated cell death in crustacean.

Virology 2018 Dec 13;528:37-47. Epub 2018 Dec 13.

College of Life Sciences and Laboratory for Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address:

In vertebrates, pyroptosis is an intense inflammatory form of programmed cell death. This death pathway is critical for controlling pathogenic infection. In invertebrates, however, due to the lack of adaptive immune response, it is still elusive whether Caspase 1-dependent cell death pathway exists. Read More

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December 2018

Adaptation of Rabensburg virus (RBGV) to vertebrate hosts by experimental evolution.

Virology 2018 Dec 13;528:30-36. Epub 2018 Dec 13.

The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY, USA; Department of Biomedical Sciences, State University of New York at Albany School of Public Health, Albany, NY, USA.

Rabensburg virus (RBGV; Flaviviridae, Flavivirus) has been classified as both a novel flavivirus and a unique lineage of West Nile virus (WNV). RBGV and WNV share approximately 76% sequence homology, yet RBGV does not replicate to high viral titers within vertebrate cell lines at physiological temperatures and has not been naturally isolated from a vertebrate host. These unique genetic and biological characteristics make RBGV a viable tool to identify the genetic determinants of flavivirus infectivity and fitness in vertebrate hosts. Read More

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December 2018

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method.

J Mol Graph Model 2018 Nov 28;87:204-210. Epub 2018 Nov 28.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa. Electronic address:

Tuberculosis (TB) is one of the world's deadliest diseases resulting from infection by the bacterium, Mycobacterium tuberculosis (M.tb). The L,D-transpeptidase enzymes catalyze the synthesis of 3 → 3 transpeptide linkages which are predominant in the peptidoglycan of the M. Read More

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November 2018

Engineered nanomaterials inhibit Podosphaera pannosa infection on rose leaves by regulating phytohormones.

Environ Res 2018 Dec 6;170:1-6. Epub 2018 Dec 6.

Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, MA 01003, United States.

In the present study, we investigated the antifungal effects of engineered nanomaterials (ENMs) against Podosphaera pannosa (P. pannosa), a fungal pathogen that causes powdery mildew on plants in the rose family. Four commercial ENMs, including multi-wall carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), copper oxide (CuO) nanoparticles (NPs) and titanium dioxide (TiO) NPs, were used to prepare 50 or 200 mg/L NP suspensions in deionized water. Read More

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December 2018

Phospholipase A2 products predict the hematopoietic support capacity of horse serum.

Differentiation 2018 Dec 6;105:27-32. Epub 2018 Dec 6.

Department of Hematology and Oncology, Medical Faculty, University of Leipzig, Leipzig, Germany.

Horse serum is commonly used as an additive to support the maintenance of hematopoietic progenitor cells in culture. However, the wide variability in the performance of different lots calls for parallel testing of multiple batches over extended periods of culture. Identification of the serum components that determine hematopoietic support would therefore save considerable time and effort and would help to standardize culture procedures. Read More

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December 2018

A new sequence based encoding for prediction of host-pathogen protein interactions.

Comput Biol Chem 2018 Dec 5;78:170-177. Epub 2018 Dec 5.

Department of Computer and Information Sciences, Sakarya University, Serdivan, Sakarya, 54050, Turkey.

Pathogen-host interactions are very important to figure out the infection process at the molecular level, where pathogen proteins physically bind to human proteins to manipulate critical biological processes in the host cell. Data scarcity and data unavailability are two major problems for computational approaches in the prediction of pathogen-host interactions. Developing a computational method to predict pathogen-host interactions with high accuracy, based on protein sequences alone, is of great importance because it can eliminate these problems. Read More

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December 2018

A novel ferritin gene from Procambarus clarkii involved in the immune defense against Aeromonas hydrophila infection and inhibits WSSV replication.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Ferritin is a protein related to the storage of iron and widely distributed in animals. It participates in many biological process, including antioxidation, cell activation, angiogenesis, regulation of iron metabolic balance and immune defense. In the present study, a novel ferritin gene was identified from red swamp crayfish Procambarus clarkii, with a cDNA sequence encoding a predicted 221 amino-acid residues. Read More

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December 2018

Hematopoietic tissue of Macrobrachium rosenbergii plays dual roles as a source of hemocyte hematopoiesis and as a defensive mechanism against Macrobrachium rosenbergii nodavirus infection.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand; Nakhonsawan Campus, Mahidol University, Nakhonsawan, 60130, Thailand. Electronic address:

White tail disease caused by Macrobrachium rosenbergii nodavirus (MrNV) infection takes place only in nauplii, not adults, of M. rosenbergii prawn. Hemocyte homeostasis and immune-related functions derived from the hematopoietic tissue (Hpt) in adult prawn are presumed to play roles in resisting viral infection. Read More

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December 2018

The comparisons in protective mechanisms and efficiencies among dietary α-lipoic acid, β-glucan and l-carnitine on Nile tilapia infected by Aeromonas hydrophila.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, 200241, PR China. Electronic address:

Dietary α-lipoic acid (LA), β-glucan (Gluc) and l-carnitine (L-Ca) are commonly used additives to promote fish growth and stress resistance in aquaculture production. However their mechanisms and efficiencies in helping fish to resist diseases have not been compared before. In this study, we fed Nile tilapia (Oreochromis niloticus) with diets containing appropriate doses of LA, Gluc and L-Ca for five weeks and further intraperitoneally injected the fish with Aeromonas hydrophila. Read More

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December 2018

Accuracy of IP-10 for diagnosing latent tuberculosis infection: a systematic review and meta-analysis.

Clin Microbiol Infect 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China. Electronic address:

Background: Effective diagnostic methods for detecting latent tuberculosis infection (LTBI) are important for its eradication. A number of studies have evaluated the use of interferon gamma-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported.

Objectives: Our objective was to assess the diagnostic value of IP-10 for LTBI. Read More

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December 2018

Reconciling estimates of the global influenza burden.

Lancet Respir Med 2018 Dec 12. Epub 2018 Dec 12.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China.

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December 2018

What are the main drivers for public policies to prevent healthcare-associated infections?

J Hosp Infect 2018 Dec 13. Epub 2018 Dec 13.

Nottingham University Business School. Nottingham, UK.

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December 2018

A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR.

Biochim Biophys Acta Proteins Proteom 2018 Dec 13. Epub 2018 Dec 13.

Unité Microbiologie, Bioorganique et Macromoléculaire (CP206/04), département R3D, Faculté de Pharmacie, Université Libre de Bruxelles, B-1050 Brussels, Belgium. Electronic address:

The Mycobacterium tuberculosis EthR is a member of the TetR family of repressors, controlling the expression of EthA, a mono-oxygenase responsible for the bioactivation of the prodrug ethionamide. This protein was established as a promising therapeutic target against tuberculosis, allowing, when inhibited by a drug-like molecule, to boost the action of ethionamide. Dozens of EthR crystal structures have been solved in complex with ligands. Read More

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December 2018

The critical role of microRNAs in stress response: therapeutic prospect and limitation.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:

Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More

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December 2018

A large-volume academic center retrospective audit of the temporal evolution of immediate breast reconstruction protocols and the effect on breast prosthetic infection.

J Plast Reconstr Aesthet Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD 21287, United States.

Background: Complications of tissue expanders (TEs) in breast reconstruction are challenging. We sought to identify TE infection risks and acellular dermal matrix (ADM) and infection control protocol impacts on infection in a longitudinal study.

Methods: We retrospectively analyzed TE/implant reconstructions in 2004 (no ADM), 2009 (TE and ADM), 2013 (TE, ADM, and infection control protocol), and 2015 (TE, ADM, and infection control protocol). Read More

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November 2018
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Borrelia burgdorferi sensu lato infection in patients with peripheral facial palsy.

Ticks Tick Borne Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

The aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology. Adult patients with PFP who presented at our department between January 2006 and December 2013 qualified for the study if they had undergone lumbar puncture and also been tested for the presence of borrelial IgM and IgG antibodies in serum and cerebrospinal fluid (CSF) in indirect chemiluminescence immunoassay. Patients with PFP who had obvious signs/symptoms indicating a disease other than Lyme borreliosis (LB) were excluded. Read More

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December 2018

Chronic hepatitis C infection - Noninvasive assessment of liver fibrosis in the era of direct acting antivirals.

Dig Liver Dis 2018 Nov 28. Epub 2018 Nov 28.

Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

Significant advancements in the diagnosis and treatment of chronic hepatitis C infection and its associated fibrosis have revolutionized treatment of these patients over the last several years. Liver biopsy, the gold standard diagnostic method for evaluating liver fibrosis level, was routinely used prior to initiation of hepatitis C therapy, placing patients at an inherent risk of adverse events. The recent advent of noninvasive serologic and nonserologic measures of hepatic fibrosis level has reduced the need for liver biopsy significantly, thereby minimizing its associated risks. Read More

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November 2018

Incidence, Cost, and Risk Factors for Readmission after Coronary Artery Bypass Grafting.

Ann Thorac Surg 2018 Dec 13. Epub 2018 Dec 13.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Readmissions adversely affect hospital reimbursement and quality measures. We aimed to evaluate the incidence, cost, and risk factors for readmission following Coronary Artery Bypass Grafting (CABG).

Methods: We queried the National Readmissions Database (NRD) and isolated patients who underwent CABG from 2013-2014. Read More

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December 2018

Impact of Complications on Resource Utilization during 90-day CABG Bundle for Medicare Beneficiaries.

Ann Thorac Surg 2018 Dec 13. Epub 2018 Dec 13.

HealthTrust Purchasing Group, L.P.

Background: The study reports the impact of adverse events during the index CABG surgery on Medicare reimbursement for the index hospitalization and a 90-day follow-up period.

Methods: This retrospective study used 2014 Medicare claims files for hospitals, skilled nursing services, rehabilitation facilities, long-term care facilities, home health services and outpatient visits. The study sample is 37,106 Medicare beneficiaries that survived an index CABG in a US hospital during the first three quarters of 2014. Read More

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December 2018

Trauma Exposure, DSM-5 Post-Traumatic Stress Disorder, and Sexual Risk Outcomes.

Am J Prev Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: The current study examined associations between DSM-5 post-traumatic stress disorder (PTSD) and three sexual risk outcomes: presence of a sexually transmitted disease/infection, frequency of condom use, and sex with a known user of injection drugs.

Methods: Data were from the National Epidemiologic Survey on Alcohol and Related Conditions-III (2012-2013, analyzed 2017), a nationally representative survey of non-institutionalized U.S. Read More

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December 2018

What Lies Within?: Imaging to Detect Ventricular Assist Device Infection.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

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December 2018

A case of pulmonary mucormycosis presented as Pancoast syndrome and bone destruction in an immunocompetent adult mimicking lung carcinoma.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Zhejiang Hospital, 12, Lingyin road, 310013 Hangzhou, China. Electronic address:

Pulmonary mucormycosis is a rare opportunistic infection caused by Mucormycosis. This fungal infection is uncommon in immunocompetent individuals. Because of its various clinical and imaging manifestations, it is a diagnostic challenge to distinguish pulmonary mucormycosis from other pulmonary diseases, such as carcinoma. Read More

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December 2018

An unusual case of gastrointestinal basidiobolomycosis mimicking colon cancer; literature and review.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Mycology/Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Gastrointestinal basidiobolomycosis (GIB), a rare fungal infection associated with high mortality, has been reported worldwide mainly from tropical and subtropical regions of Asia, USA, and Latin America. The clinical manifestations are highly diverse and non-specific depending on the underlying disease, but fever, abdominal pain, weight loss, diarrhea, constipation and chills have been observed. There are no prominent risk factors for GIB but climatic conditions and life style are related to this infection in arid and semi-arid regions. Read More

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December 2018

Virulence and resistance determinants of Klebsiella pneumoniae isolated from a Portuguese tertiary university hospital centre over a 31-year period.

Enferm Infecc Microbiol Clin 2018 Dec 12. Epub 2018 Dec 12.

Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, University of Lisbon, 1649-003, Lisbon, Portugal.

Introduction: The rapid and complex evolution of bacterial resistance mechanisms in Klebsiella pneumoniae producing extended-spectrum β-lactamases and carbapenemases in Klebsiella pneumoniae is one of the most significant threats to public health. However, questions and controversies regarding the interactions between resistance and virulence in multidrug-resistant K. pneumoniae isolates remain unclear. Read More

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December 2018

Descriptive epidemiology of Yersinia enterocolitica infection in a high-incidence area over an 8-year period, 2006-2013. EDICS project.

Enferm Infecc Microbiol Clin 2018 Dec 12. Epub 2018 Dec 12.

Sección Epidemiología, Centro Salud Pública, Castelló, España; CIBER-ESP grupo 41; Departamento de Medicina, Facultad de Ciencias de la Salud, Universitat Jaume I (UJI), España. Electronic address:

Descriptive epidemiology of Yersinia enterocolitica infection in an area of Castellón (Spain) between 2006 and 2013 from Yersinia enterocolitica strains isolated in the area and confirmed by the Spanish national reference laboratory. There were a total of 144 cases. The estimated incidence was 9. Read More

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December 2018
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