5,268 results match your criteria Infection[Journal]


Multiple colonization with carbapenem-resistant Gram-negative bacteria acquired in India and transferred to Switzerland.

Infection 2019 Apr 10. Epub 2019 Apr 10.

Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 18, 1700, Fribourg, Switzerland.

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http://dx.doi.org/10.1007/s15010-019-01307-4DOI Listing

Analysis of hepatitis B virus-mixed genotype infection by ultra deep pyrosequencing in Sudanese patients, 2015-2016.

Infection 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Via Portuense, 292, 00149, Rome, Italy.

Purpose: The frequency of detection of HBV co-infection with multiple HBV genotypes is influenced by the detection method; usually co-infections are detected by multiplex PCR or hybridization assays, and are rarely confirmed by sequencing and conventional cloning. The objective of this study was to confirm by ultra-deep pyrosequencing (UDPS) mixed HBV infections, previously detected by multiplex-nested PCR.

Methods: Sixteen samples from HBV co-infected Sudanese patients detected by multiplex-nested PCR, were amplified targeting the P/S region and sequenced by UDPS. Read More

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http://dx.doi.org/10.1007/s15010-019-01306-5DOI Listing

Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis.

Infection 2019 Apr 6. Epub 2019 Apr 6.

Division of Allergy, Immunology and Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 362, New Brunswick, NJ, 08901, USA.

Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI. Read More

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http://dx.doi.org/10.1007/s15010-019-01304-7DOI Listing
April 2019
2 Reads

A case of a surgical-site infection with Staphylococcus condimenti.

Infection 2019 Apr 5. Epub 2019 Apr 5.

Department of Laboratory Medicine, AZ Sint-Jan Brugge AV, Ruddershove 10, 8000, Bruges, Belgium.

Introduction: Coagulase-negative staphylococci (CNS) are considered to have a medium or low pathogenic capacity when compared to S. aureus. Among the more harmless, CNS are those that are used in the food industry, represented by S. Read More

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http://dx.doi.org/10.1007/s15010-019-01276-8DOI Listing
April 2019
1 Read

An unusual case of post-trauma polymicrobial cutaneous diphtheria.

Infection 2019 Apr 5. Epub 2019 Apr 5.

Department of Orthopedics, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

We report a rare case of post-traumatic cutaneous diphtheria in a patient referred from a hospital in rural India. The diagnosis of cutaneous diphtheria was confirmed by the isolation of Corynebacterium diphtheriae cultured from the ulcer of the leg, along with Staphylococcus aureus, Streptococcus pyogenes, and Arcanobacterium haemolyticum. The patient was kept on isolation and treated with erythromycin for 14 days without antitoxin. Read More

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http://dx.doi.org/10.1007/s15010-019-01300-xDOI Listing

A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery.

Infection 2019 Apr 3. Epub 2019 Apr 3.

Department of Oral- and Maxillofacial Surgery, University Medical Center, Augustusplatz 2, 55131, Mainz, Germany.

Purpose: Especially in oral and maxillofacial surgery, where procedures involving the aero-digestive tract considered clean contaminated, surgical site infections (SSI) represent a severe health care burden. To improve implementation and methodological standard, an upgrade of the existing S1 guideline to a consensus-guided S3 guideline was initiated by the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. Read More

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http://dx.doi.org/10.1007/s15010-019-01303-8DOI Listing

Septic arthritis due to streptococci and enterococci in native joints: a 13 year retrospective study.

Infection 2019 Mar 30. Epub 2019 Mar 30.

Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland.

Objectives: Streptococcal species are the second most common cause of native joint septic arthritis (SA). However, there are few systematic data about streptococcal SA.

Methods: The medical records of adults with SA caused by streptococci, pneumococci, and enterococci at our tertiary care centre between 2003 and 2015 were reviewed. Read More

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http://dx.doi.org/10.1007/s15010-019-01301-wDOI Listing
March 2019
1 Read

Utility of predictive tools for risk stratification of elderly individuals with all-cause acute respiratory infection.

Infection 2019 Mar 30. Epub 2019 Mar 30.

Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC, USA.

Purpose: A number of scoring tools have been developed to predict illness severity and patient outcome for proven pneumonia, however, less is known about the utility of clinical prediction scores for all-cause acute respiratory infection (ARI), especially in elderly subjects who are at increased risk of poor outcomes.

Methods: We retrospectively analyzed risk factors and outcomes of individuals ≥ 60 years of age presenting to the emergency department with a clinical diagnosis of ARI.

Results: Of 276 individuals in the study, 40 had proven viral infection and 52 proven bacterial infection, but 184 patients with clinically adjudicated ARI (67%) remained without a proven microbial etiology despite extensive clinical (and expanded research) workup. Read More

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http://dx.doi.org/10.1007/s15010-019-01299-1DOI Listing
March 2019
2 Reads

Correction to: Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh.

Infection 2019 Mar 25. Epub 2019 Mar 25.

Department of Infectious and Tropical Diseases, Spedali Civili, Piazzale Spedali Civili, 1, 25123, Brescia, Italy.

The original version of this article unfortunately contained a mistake. Arnaldo Caruso was not listed among the authors. Read More

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http://dx.doi.org/10.1007/s15010-019-01296-4DOI Listing

GeneXpert of stool versus gastric lavage fluid for the diagnosis of pulmonary tuberculosis in severely ill adults.

Infection 2019 Mar 23. Epub 2019 Mar 23.

Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, No. 97, Machang, Tongzhou District, Beijing, 101149, China.

Purpose: Stool is an alternative specimen matrix for tuberculosis (TB) tests, because Mycobacterium tuberculosis (MTB) can be swallowed and detected in the samples from digestive tract. We aimed to assess the performance of GeneXpert on stool and gastric lavage fluid (GALF) in diagnosing TB among patients with severe pulmonary TB.

Methods: We enrolled adults with suspected pulmonary TB who were unable to produce sputum at visit between January 2016 and June 2018. Read More

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http://dx.doi.org/10.1007/s15010-019-01295-5DOI Listing
March 2019
2.618 Impact Factor

Practices, organisation, and regulatory aspects in advising on antibiotic prescription: the international ESCMID AntibioLegalMap survey.

Infection 2019 Mar 22. Epub 2019 Mar 22.

Université de Lorraine, APEMAC, 54000, Nancy, France.

Purpose: Giving advice about antibiotic prescription through dedicated consultations is a cornerstone of antibiotic stewardship programmes. Our objective was to explore practices, organisation, and regulatory requirements related to antibiotic advising.

Methods: We performed an international, exploratory, Internet-based, cross-sectional survey targeting infectious diseases and clinical microbiology specialists. Read More

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http://dx.doi.org/10.1007/s15010-019-01298-2DOI Listing

Severe progressive cutaneous infection caused by Fonsecaea monophora in a patient after trauma.

Infection 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology and Venerology, Peking University First Hospital, 1st Xi'an men Street, Xicheng District, Beijing, 100034, China.

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http://dx.doi.org/10.1007/s15010-019-01293-7DOI Listing

Asymptomatic Leishmania infection in blood donors from the Southern of Spain.

Infection 2019 Mar 19. Epub 2019 Mar 19.

Department of Parasitology, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, s/n, 18011, Granada, Spain.

Objectives: To investigate the proportion of asymptomatic infection among blood donors in a region endemic for Leishmania; and to ascertain epidemiological and genetic factors associated with this condition.

Methods: We studied 1260 blood donors in the Province of Granada in the Southern Spain. After obtaining informed consent in each participant, a poll about habits, housing and contact with animals were carried out. Read More

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http://dx.doi.org/10.1007/s15010-019-01297-3DOI Listing

Vertebral osteomyelitis due to Candida species.

Infection 2019 Mar 13. Epub 2019 Mar 13.

Department of Pathology and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Objective: We have noted an increased number of cases of vertebral osteomyelitis secondary to Candida species over the past few years at our facility. Our aim was to identify and review these cases to elucidate risk factors, treatment regimens and outcomes.

Methods: We performed a retrospective chart review using our electronic medical record and microbiology laboratory database to identify cases of vertebral osteomyelitis due to Candida at a single teaching hospital from 2006-2018. Read More

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http://dx.doi.org/10.1007/s15010-019-01294-6DOI Listing

Correction to: Recurrent cholera epidemics in Africa: which way forward? A literature review.

Infection 2019 Mar 11. Epub 2019 Mar 11.

Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.

The original version of this article unfortunately contained a mistake. In the introduction, the infectious dose of Vibrio cholerae was written as 103-108 instead of 10-10 cells. Read More

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http://dx.doi.org/10.1007/s15010-019-01292-8DOI Listing

Diagnostic challenges in infective endocarditis: is PET/CT the solution?

Infection 2019 Feb 13. Epub 2019 Feb 13.

Department I of Internal Medicine, University of Cologne, KerpenerStraße 62, 50937, Cologne, Germany.

Purpose: Despite developments in both imaging and microbiological techniques, the final diagnosis of IE often remains challenging. In this single-center cohort study, we aimed to identify the specific indications for request of F-FDG-PET/CT in clinical practice and to evaluate the diagnostic benefit of this nuclear imaging technique.

Methods: A total of 235 patients with possible (n = 43) or definite (n = 192) IE according to the revised Duke criteria were prospectively studied from July 2013 until December 2016. Read More

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http://dx.doi.org/10.1007/s15010-019-01278-6DOI Listing
February 2019
1 Read

AmpC β-lactamase-producing Enterobacterales: what a clinician should know.

Infection 2019 Mar 6. Epub 2019 Mar 6.

Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.

Background: Enterobacterales are among the most common causes of bacterial infections in the community and among hospitalized patients, and multidrug-resistant (MDR) strains have emerged as a major threat to human health. Resistance to third-generation cephalosporins is typical of MDRs, being mainly due to the production of extended spectrum β-lactamases or AmpC-type β-lactamases.

Objective: The objective of this paper is to review the epidemiological impact, diagnostic issues and treatment options with AmpC producers. Read More

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http://dx.doi.org/10.1007/s15010-019-01291-9DOI Listing
March 2019
14 Reads

Correction to: The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from Sub-Saharan Africa.

Infection 2019 Mar 4. Epub 2019 Mar 4.

Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

The original version of this article unfortunately contained a mistake. The given name and family name of Filippo Parretti was transposed in the original publication. The correct name is as shown above. Read More

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http://link.springer.com/10.1007/s15010-019-01283-9
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http://dx.doi.org/10.1007/s15010-019-01283-9DOI Listing
March 2019
3 Reads
2.618 Impact Factor

Efficacy of teicoplanin monotherapy following initial standard therapy in Enterococcus faecalis infective endocarditis: a retrospective cohort study.

Infection 2019 Feb 27. Epub 2019 Feb 27.

Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac TSA 40031, 31059, Toulouse CEDEX 9, France.

Purpose: Teicoplanin is often used in Enterococcus faecalis infective endocarditis as a relay in case of penicillin side effects, or in outpatients. We assessed the efficacy of teicoplanin used as continuation therapy after initial standard treatment of E. faecalis endocarditis. Read More

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http://dx.doi.org/10.1007/s15010-019-01290-wDOI Listing
February 2019

Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment.

Infection 2019 Feb 26. Epub 2019 Feb 26.

National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Via Portuense, 292, 00149, Rome, Italy.

Objectives: In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, and reduction of recrudescence or reinfection.

Methods: We describe five cases of Plasmodium vivax malaria in returning travelers treated with dihydroartemisinin-piperaquine. Read More

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http://dx.doi.org/10.1007/s15010-019-01286-6DOI Listing
February 2019
1 Read

Appropriate use of antifungals: impact of an antifungal stewardship program on the clinical outcome of candidaemia in a French University Hospital.

Infection 2019 Feb 26. Epub 2019 Feb 26.

Service de pharmacie, Pharmacie centrale, Centre Hospitalier Universitaire de Caen, avenue Côte de Nacre, 14033, Caen Cedex 9, France.

Objectives: The objective of this study was to compare clinical outcomes of patients with candidaemia before and after implementation of an antifungal stewardship program (AFSP).

Methods: This study included all consecutive cases of candidaemia identified from January 2012 to December 2015 in a French University Hospital. Data were collected retrospectively for a period of 2 years before implementation of the AFSP, and prospectively for 2 years after. Read More

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http://dx.doi.org/10.1007/s15010-018-01264-4DOI Listing
February 2019

Correction to: Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016.

Infection 2019 Apr;47(2):257

Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

In this article the cooperating partners of the ClinSurv HIV cohort were not listed in the acknowledgements. The correct paragraph appears below. Read More

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http://dx.doi.org/10.1007/s15010-019-01281-xDOI Listing

Latent tuberculosis infection in transplant candidates: a systematic review and meta-analysis on TST and IGRA.

Infection 2019 Feb 25. Epub 2019 Feb 25.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: The diagnostic accuracy of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST) for latent tuberculosis infection (LTBI) in transplant candidates is uncertain.

Methods: Pubmed, Embase and Cochrane library were searched to identify relevant studies. Quality of included studies was assessed with RevMan5 software (via GUADAS2 checklist). Read More

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http://dx.doi.org/10.1007/s15010-019-01285-7DOI Listing
February 2019
2.618 Impact Factor

Improving quality of antifungal use through antifungal stewardship interventions.

Infection 2019 Feb 25. Epub 2019 Feb 25.

Department of Haematology/Oncology, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.

Purpose: In recent years antifungal stewardship (AFS) programmes have been increasingly recommended to provide optimal antifungal treatment. In a previous study (study I) in the department of haematology and oncology of a German tertiary care hospital we found areas for improvement concerning antifungal prescription. Subsequently, AFS measures were implemented and their impact on quality of antifungal use was assessed in this study. Read More

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http://dx.doi.org/10.1007/s15010-019-01288-4DOI Listing
February 2019
2 Reads

Respiratory syncytial virus contributes to more severe respiratory morbidity than influenza in children < 2 years during seasonal influenza peaks.

Infection 2019 Feb 23. Epub 2019 Feb 23.

Institut National de Santé Publique du Québec, 2400 Avenue d'Estimauville, Quebec, QC, G1E 7G9, Canada.

Purpose: To compare the frequency and the severity of influenza and respiratory syncytial viruses (RSV) infections among children < 24 months hospitalized with respiratory symptoms.

Methods: Data from a prospective study conducted during the peak of five influenza seasons in the Province of Quebec, Canada were used.

Results: We detected higher frequency of RSV compared to influenza viruses (55. Read More

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http://dx.doi.org/10.1007/s15010-019-01287-5DOI Listing
February 2019

Genomic epidemiology of MRSA infection and colonization isolates among military trainees with skin and soft tissue infection.

Infection 2019 Feb 22. Epub 2019 Feb 22.

Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Purpose: Individuals with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI) can be simultaneously colonized with MRSA on multiple body sites. Using whole genome sequencing (WGS), the intrahost relatedness of MRSA colonization and infection isolates was investigated.

Methods: In the context of a prospective case-control study of SSTI, we analyzed colonization and infection isolates from US Army Infantry trainees with purulent infection due to MRSA. Read More

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http://link.springer.com/10.1007/s15010-019-01282-w
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http://dx.doi.org/10.1007/s15010-019-01282-wDOI Listing
February 2019
5 Reads

Liver fibrosis is associated with cognitive impairment in people living with HIV.

Infection 2019 Feb 19. Epub 2019 Feb 19.

Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy.

Purpose: Our aim was to better explore the association between liver fibrosis (LF) and neurocognitive impairment (NCI) in people living with HIV (PLWH).

Methods: We performed a cross-sectional cohort study by consecutively enrolling PLWH at two clinical centers. All subjects underwent a comprehensive neuropsychological battery; NCI was defined as having a pathological performance (1. Read More

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http://link.springer.com/10.1007/s15010-019-01284-8
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http://dx.doi.org/10.1007/s15010-019-01284-8DOI Listing
February 2019
12 Reads

Focal spleen lesions in visceral leishmaniasis, a neglected manifestation of a neglected disease: report of three cases and systematic review of literature.

Infection 2019 Feb 15. Epub 2019 Feb 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: The Mediterranean area is endemic for the zoonotic form of visceral leishmaniasis (VL) caused by Leishmania infantum, a species which has been recently associated with unexpected epidemiological and clinical features.

Method: We report the result of a systematic review of the literature on VL unusually presenting with spleen focal lesions, including three previously unpublished cases.

Results: A total of 28 cases of VL with multiple spleen focal lesions were retrieved. Read More

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http://dx.doi.org/10.1007/s15010-019-01279-5DOI Listing
February 2019
1 Read

Acute epididymo-orchitis due to Salmonella Typhi in a young man from Bangladesh.

Infection 2019 Feb 15. Epub 2019 Feb 15.

Department of Infectious and Tropical Diseases, Spedali Civili, Piazzale Spedali Civili, 1, 25123, Brescia, Italy.

S. typhi infection rarely involves the genitourinary system. We report the first described case of acute epididymo-orchitis due to S. Read More

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http://dx.doi.org/10.1007/s15010-019-01280-yDOI Listing
February 2019

Derivation of a quick Pitt bacteremia score to predict mortality in patients with Gram-negative bloodstream infection.

Infection 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine, Palmetto Health University of South Carolina Medical Group, Columbia, SC, USA.

Purpose: This retrospective cohort study derived a "quick" version of the Pitt bacteremia score (qPitt) using binary variables in patients with Gram-negative bloodstream infections (BSI). The qPitt discrimination was then compared to quick sepsis-related organ failure assessment (qSOFA) and systemic inflammatory response syndrome (SIRS).

Methods: Hospitalized adults with Gram-negative BSI at Palmetto Health hospitals in Columbia, SC, USA from 2010 to 2013 were identified. Read More

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http://dx.doi.org/10.1007/s15010-019-01277-7DOI Listing
February 2019
14 Reads

Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection.

Infection 2019 Feb 7. Epub 2019 Feb 7.

Center of Clinical Laboratory, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Introduction: A woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study.

Case Report: Tigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Read More

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http://dx.doi.org/10.1007/s15010-019-01274-wDOI Listing
February 2019
2 Reads

Invasive fungal disease is associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplant: a single center, retrospective study.

Infection 2019 Apr 7;47(2):275-284. Epub 2019 Feb 7.

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Invasive fungal disease (IFD) and graft-versus-host disease (GVHD) are major causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the impacts of IFD on chronic GVHD remain unknown.

Methods: We conducted a retrospective study of 510 patients with hematologic malignancy undergoing allo-HSCT to explore the effects of IFD on chronic GVHD. Read More

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http://dx.doi.org/10.1007/s15010-018-01265-3DOI Listing
April 2019
6 Reads

First reported human case of meningitis by Staphylococcus condimenti.

Infection 2019 Feb 7. Epub 2019 Feb 7.

S.C.D.U. Medicina Interna I, A.O.U. Maggiore Della Carità, Università del Piemonte Orientale, via Mazzini 18, 28100, Novara, Italy.

Staphylococcus condimenti (S. condimenti) is a coagulase-negative bacterium, generally regarded as not pathogenic. Indeed, S. Read More

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http://dx.doi.org/10.1007/s15010-018-01266-2DOI Listing
February 2019
2 Reads

In vitro activity of voriconazole and amphotericin B against Candida albicans, Candida krusei, and Cryptococcus neoformans in human cerebrospinal fluid.

Infection 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Pharmacology, Vienna University Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: Fungal central nervous system (CNS) infections show a high mortality rate and only a few antifungal agents are available to treat these infections. We hypothesize that the different biochemical properties of human cerebrospinal fluid (CSF) compared to the standard growth medium lead to the altered activity of antifungal agents in CSF. We investigated the in vitro activity of two of these agents, i. Read More

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http://dx.doi.org/10.1007/s15010-019-01275-9DOI Listing
February 2019

HBsAg-negative/anti-HBc-positive patients treated with rituximab: prophylaxis or monitoring to prevent hepatitis B reactivation?

Infection 2019 Apr 28;47(2):293-300. Epub 2019 Jan 28.

Department I of Internal Medicine, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Rituximab (RTX) has been classified as a drug associated with a high risk for hepatitis B virus (HBV) reactivation in HbsAg-negative/anti-HBc-positive patients. However, data on frequency of HBV reactivation are limited especially for RTX monotherapy. Several new recommendations for screening, monitoring and prophylactic antiviral treatment have been published recently. Read More

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http://dx.doi.org/10.1007/s15010-019-01271-zDOI Listing
April 2019
3 Reads

M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections.

Infection 2019 Jan 28. Epub 2019 Jan 28.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Purpose: To assess the incidence of Mycoplasma pneumoniae and Chlamydia pneumoniae in the pathogenesis of hospital-acquired respiratory tract infections (RTIs) in critically ill patients.

Methods: This is a retrospective cohort study of all ICU-patients ≥ 18 years with RTI who underwent conventional culture techniques and PCR testing for both M. pneumoniae and C. Read More

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http://dx.doi.org/10.1007/s15010-019-01273-xDOI Listing
January 2019
3 Reads

Sepsis: a frequent topic in a new Editorial Section in INFECTION.

Authors:
J R Bogner

Infection 2019 Feb;47(1):1-2

Klinik und Poliklinik IV, Sektion Klinische Infektiologie, Klinikum der Universität München, Pettenkoferstr. 8a, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s15010-019-01272-yDOI Listing
February 2019

The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from Sub-Saharan Africa.

Infection 2019 Jan 21. Epub 2019 Jan 21.

Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

Objectives: To evaluate ultrasound and praziquantel to, respectively, assess and reduce urogenital schistosomiasis (UGS)-associated morbidity in migrants from Sub-Saharan Africa (SSA).

Methods: Migrants from SSA with UGS attending three Italian centres for tropical diseases during 2011-2016 were retrospectively enrolled. Data on clinical symptoms, routine laboratory, parasitological tests, and ultrasound reported as per the WHO-Niamey protocol were collected at baseline and at available follow-up visits after treatment with praziquantel 40 mg/kg/day for 3 days. Read More

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http://dx.doi.org/10.1007/s15010-019-01270-0DOI Listing
January 2019
6 Reads
2.618 Impact Factor

Post-malaria neurological syndrome: a rare neurological complication of malaria.

Infection 2019 Apr 21;47(2):183-193. Epub 2019 Jan 21.

Department of Medicine, Division of Infectious Disease, SUNY Upstate Medical Center, Syracuse, NY, USA.

Background: Post-malaria neurological syndrome (PMNS) is a rare self-limiting neurological complication that can occur after recovery from malaria, usually severe falciparum malaria. It is characterized by a myriad of neuropsychiatric manifestations including mild neurological deficit to severe encephalopathy. PMNS was first described in 1996 and since then there have been 48 cases reported in the English literature. Read More

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http://dx.doi.org/10.1007/s15010-019-01267-9DOI Listing

Tularemia: an experience of 13 cases including a rare myocarditis in a referral center in Eastern Switzerland (Central Europe) and a review of the literature.

Infection 2019 Jan 17. Epub 2019 Jan 17.

Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland.

Background: Tularemia, a zoonotic disease caused by Francisella tularensis, can cause a broad spectrum of disease in humans including six major clinical presentations: the ulceroglandular, glandular, oculoglandular, oropharyngeal, typhoidal and pneumonic form. The epidemiology and ecology and thus transmission of tularemia are complex, depending on conditions unique to specific locations.

Case Series And Methods: Thirteen cases with different forms of the disease and one very rare case of a myocarditis are reported, discussed, and reviewed within the scope of current literature. Read More

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http://dx.doi.org/10.1007/s15010-019-01269-7DOI Listing
January 2019
2 Reads

Cerebrospinal fluid compartmentalization of HIV-1 and correlation with plasma viral load and blood-brain barrier damage.

Infection 2019 Jan 16. Epub 2019 Jan 16.

Clinic of Infectious Diseases, University of Bari "Aldo Moro", Piazza G. Cesare, 11, 70124, Bari, Italy.

Purpose: We aimed to evaluate HIV-1 compartmentalization between the cerebrospinal fluid (CSF) and plasma and investigate as to which extent HIV-1 strains in CSF differ from those in blood and whether a correlation with either plasma viral load (pVL) or an altered blood-brain barrier (BBB) does exist.

Study Design: We retrospectively evaluated paired CSF/blood samples collected from 86 HIV+ patients. HIV-RNA quantification, pol (PR/RT), and V3 sequencing were performed. Read More

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http://dx.doi.org/10.1007/s15010-019-01268-8DOI Listing
January 2019
1 Read

Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.

Infection 2019 Jan 16. Epub 2019 Jan 16.

Kliniken für Pneumologie und Infektiologie, EVK Herne und Augusta-Kranken-Anstalt Bochum, Thoraxzentrum Ruhrgebiet, Bergstrasse 26, 44791, Bochum, Germany.

Purpose: We studied the incidence, morbidity and mortality of all patients presenting in our teaching hospital with proven influenza virus and/or respiratory syncytial virus (RSV) infection during the influenza epidemic season 2018 which was characterized by a predominant incidence of influenza virus B type B of the Yamagata line.

Methods: In the fall of 2017, specific precaution measures in addition to standard measures were implemented, including standardized testing for influenza virus A,B and RSV by multiplex PCR of pharyngeal swabsData from all consecutive patients were analyzed retrospectively.

Results: Overall 651 patients were examined for the presence of influenza virus and RSV; 214 patients had influenza virus A (n = 36), B (n = 152), and/or RSV (n = 30), including four patients with dual infection. Read More

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http://link.springer.com/10.1007/s15010-018-1262-x
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http://dx.doi.org/10.1007/s15010-018-1262-xDOI Listing
January 2019
32 Reads

Correction to: Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series.

Infection 2019 Apr;47(2):335

Division of Infectious Diseases, American University of Beirut Medical Center, Riad El Solh, PO Box 11‑0236, Beirut, 1107 2020, Lebanon.

Unfortunately, the original version of this article contains mistakes. The names "Jean El-Cheikh" and Aline El Zakhem were spelled incorrectly. Read More

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http://dx.doi.org/10.1007/s15010-018-1259-5DOI Listing
April 2019
6 Reads
2.618 Impact Factor

Management of early- and late-onset sepsis: results from a survey in 80 German NICUs.

Infection 2019 Jan 3. Epub 2019 Jan 3.

Department of Pediatric Hematology and Oncology, Children's Hospital Medical Center, University Hospital of Saarland, Gebäude 9, Kirrberger Straße, 66421, Homburg/Saar, Germany.

Purpose: The management of early- (EOS) and late-onset sepsis (LOS) and neonatal intensive care units (NICUs) has not been extensively evaluated.

Methods: 231 highly specialized level 1 and level 2 NICUs in Germany were asked to participate in an internet-based survey.

Results: The final analysis of anonymized datasets from 80 NICUs (response rate 34. Read More

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http://dx.doi.org/10.1007/s15010-018-1263-9DOI Listing
January 2019
1 Read

Enterococcal bacteremia in febrile neutropenic children and adolescents with underlying malignancies, and clinical impact of vancomycin resistance.

Infection 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Purpose: Enterococci are a common cause of bacteremia in immunocompromised patients. Although the increase of vancomycin-resistant enterococci (VRE) makes appropriate antibiotic therapy difficult, clinical characteristics of enterococcal bacteremia and the impact of VRE infection on outcomes have rarely been reported in immunocompromised children.

Methods: We enrolled children and adolescents (< 19 years of age) with underlying malignancies who were diagnosed with enterococcal bacteremia during febrile neutropenia between 2010 and 2017. Read More

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http://dx.doi.org/10.1007/s15010-018-1260-zDOI Listing
December 2018
1 Read

Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime-avibactam.

Infection 2019 Apr 19;47(2):289-292. Epub 2018 Dec 19.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, P° Vall d'Hebron 119-129, 08035, Barcelona, Spain.

We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime-avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime-avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. Read More

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http://link.springer.com/10.1007/s15010-018-1261-y
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http://dx.doi.org/10.1007/s15010-018-1261-yDOI Listing
April 2019
5 Reads

Suboptimal performance of APRI and FIB-4 in ruling out significant fibrosis and confirming cirrhosis in HIV/HCV co-infected and HCV mono-infected patients.

Infection 2018 Dec 5. Epub 2018 Dec 5.

Department of Sciences for Health Promotion "G. D'Alessandro", University of Palermo, Palermo, Italy.

Purpose: We aimed to assess the diagnostic reliability of two indirect biomarkers, APRI and FIB-4, for the staging of liver fibrosis using transient elastography (TE) as reference standard, among HIV/HCV co-infected and HCV mono-infected patients.

Methods: This is an observational, retrospective study on subjects who had access to the RESIST HCV from October 2013 to December 2016, a regional network encompassing 22 hospitals and academic centers throughout Sicily. Sensitivity, specificity and diagnostic accuracy of indirect biomarkers for liver stiffness measurement (LSM) < 9. Read More

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http://dx.doi.org/10.1007/s15010-018-1258-6DOI Listing
December 2018
10 Reads

Challenges in HSV encephalitis: normocellular CSF, unremarkable CCT, and atypical MRI findings.

Infection 2019 Apr 1;47(2):267-273. Epub 2018 Dec 1.

Department of Neurology, Klinikum der Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: Herpes simplex virus (HSV) encephalitis continues to be the most common form of sporadic lethal encephalitis worldwide. The wide spectrum of clinical presentations and laboratory findings often poses a diagnostic challenge for physicians which might delay administration of life-saving therapy with acyclovir. Atypical presentations of HSV encephalitis have become increasingly prevalent with better diagnostic techniques and have not been well studied. Read More

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http://link.springer.com/10.1007/s15010-018-1257-7
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http://dx.doi.org/10.1007/s15010-018-1257-7DOI Listing
April 2019
15 Reads

Correction to: A review on anti-adhesion therapies of bacterial diseases.

Infection 2019 02;47(1):25-26

Department of Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

The presentation of Table  was incorrect. The corrected table is given below. Read More

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http://dx.doi.org/10.1007/s15010-018-1240-3DOI Listing
February 2019
1 Read