1,187,800 results match your criteria Infants & Young Children[Journal]


Patent ductus arteriosus and small for gestational age infants: Treatment approaches and outcomes.

Early Hum Dev 2019 Feb 13;131:10-14. Epub 2019 Feb 13.

Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: The current treatment approach in patent ductus arteriosus suggests the identification of high-risk infants that may benefit the most from treatment. Small for gestational age infants are a high-risk population in which the treatment approach to the patent ductus arteriosus and outcomes have not been described.

Aim: To compare the patent ductus arteriosus treatment approach and outcomes in small for gestational age and appropriate for gestational age infants. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.002DOI Listing
February 2019

A novel method for examining corneal endothelial cell morphology in infants.

Authors:
Jay Self

J AAPOS 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Medicine, University of Southampton, Southampton, United Kingdom, University Hospital Southampton, Southampton.

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http://dx.doi.org/10.1016/j.jaapos.2019.01.011DOI Listing
February 2019

Habituation and Novelty Detection fNIRS brain responses in 5 and 8 month old infants: The Gambia and UK.

Dev Sci 2019 Feb 16:e12817. Epub 2019 Feb 16.

Department of Medical Physics and Biomedical Engineering, University College London, UK.

The first 1000 days of life are a critical window of vulnerability to exposure to socio-economic and health challenges (i.e. poverty/undernutrition). Read More

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http://dx.doi.org/10.1111/desc.12817DOI Listing
February 2019

The impact of improved water, sanitation and hygiene on oral rotavirus vaccine immunogenicity in Zimbabwean infants: sub-study of a cluster-randomized trial.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Background: Oral vaccines have lower efficacy in developing compared to developed countries. Poor water, sanitation and hygiene (WASH) may contribute to reduced oral vaccine immunogenicity.

Methods: We conducted a cluster-randomized 2x2 factorial trial in rural Zimbabwe (NCT01824940). Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz140DOI Listing
February 2019
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A Pregnancy Cohort to Study Multidimensional Correlates of Preterm Birth in India: Study Design, Implementation, and Baseline Characteristics of the Participants.

Am J Epidemiol 2019 Feb 16. Epub 2019 Feb 16.

Regional Centre for Biotechnology, National Capital Region Biotech Cluster, Faridabad, Delhi NCR, India.

Globally, preterm birth is a major public health problem. In India, 3.6 million of the 27 million infants born annually are preterm. Read More

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http://dx.doi.org/10.1093/aje/kwy284DOI Listing
February 2019

Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To determine the prevalence of limited health literacy in parents of infants born ≤32 and 0/7 weeks and if health literacy changes during hospitalization.

Study Design: Multi-site, prospective cohort study measuring health literacy using the Parent Health Literacy Activities Test, which estimates caregivers' ability to complete tasks such as reading prescription labels and preparing bottles. Data were analyzed using parametric and nonparametric comparison tests and multivariable regression to control for confounders. Read More

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http://dx.doi.org/10.1038/s41372-019-0340-yDOI Listing
February 2019

The Relationship between blood pressure parameters and left ventricular output in neonates.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

Objective: To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow.

Study Design: This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Read More

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http://dx.doi.org/10.1038/s41372-019-0337-6DOI Listing
February 2019

Is early caffeine therapy safe and effective for ventilated preterm infants?

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41372-019-0336-7DOI Listing
February 2019

Comparison of early postnatal prediction models for survival in congenital diaphragmatic hernia.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Objective: To compare the PF-PCO equation-partial pressure of arterial oxygen (PaO)/fraction of inspired oxygen (FiO) minus partial pressure of carbon dioxide (PCO)-to three other tools for postnatal prediction of survival in infants with congenital diaphragmatic hernia (CDH).

Study Design: A retrospective analysis of 203 infants with CDH from 1 January 2003 to 30 June 2018. Area under the curve (AUC) analysis was performed for survival and secondary outcomes of survival without extracorporeal membrane oxygenation support (ECMO) and death despite ECMO. Read More

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http://dx.doi.org/10.1038/s41372-019-0335-8DOI Listing
February 2019

Placental findings among newborns with hypoxic ischemic encephalopathy.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA.

Objective: To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy.

Study Design: Retrospective case-control study of newborns with HIE (2006-2014) and controls matched for birth year, gestational age, weight, and gender. One pathologist reviewed archived placental sections using pre-specified criteria. Read More

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http://dx.doi.org/10.1038/s41372-019-0334-9DOI Listing
February 2019

Maternal preeclampsia and respiratory outcomes in extremely premature infants.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive.

Objective: To determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0336-5DOI Listing
February 2019

Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms.

Microbiome 2019 Feb 15;7(1):26. Epub 2019 Feb 15.

Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.

Background: Fungal infections are a significant cause of mortality and morbidity in hospitalized preterm infants, yet little is known about eukaryotic colonization of infants and of the neonatal intensive care unit as a possible source of colonizing strains. This is partly because microbiome studies often utilize bacterial 16S rRNA marker gene sequencing, a technique that is blind to eukaryotic organisms. Knowledge gaps exist regarding the phylogeny and microdiversity of eukaryotes that colonize hospitalized infants, as well as potential reservoirs of eukaryotes in the hospital room built environment. Read More

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http://dx.doi.org/10.1186/s40168-019-0638-1DOI Listing
February 2019

Branch pulmonary artery stenting in children by using premounted stents: Can we benefit from slenderization?

Catheter Cardiovasc Interv 2019 Feb;93(3):E198-E199

Department of Cardiology, Texas Heart Institute, Houston, Texas.

Children with branch pulmonary artery stenosis represent a challenging cohort for stenting Premounted stent implantation provides immediate obstruction relief and hemodynamic improvement in infants Planned stent intervention is required to account for somatic growth and next stage palliation in children Continued slenderization of adult coronary and peripheral interventions, stent technology, and delivery systems may allow for more durable solutions in light of patient size. Read More

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http://dx.doi.org/10.1002/ccd.28010DOI Listing
February 2019

Application of three-dimensional printing in pediatric living donor liver transplantation: a single-center experience.

Liver Transpl 2019 Feb 15. Epub 2019 Feb 15.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.

Background & Aims: Three-dimensional (3D) printing has been used to support organ translations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D printed liver models in pediatric living donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1002/lt.25435DOI Listing
February 2019

Self-generated Variability in Object Images Predicts Vocabulary Growth.

Dev Sci 2019 Feb 15:e12816. Epub 2019 Feb 15.

Indiana University, Bloomington.

Object names are a major component of early vocabularies and learning object names depends on being able to visually recognize objects in the world. However, the fundamental visual challenge of the moment-to-moment variations in object appearances that learners must resolve has received little attention in word learning research. Here we provide the first evidence that image-level object variability matters and may be the link that connects infant object manipulation to vocabulary development. Read More

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http://dx.doi.org/10.1111/desc.12816DOI Listing
February 2019

Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

Background: It has been proposed that the fetus prioritizes iron for hemoglobin production over delivery to tissues. However, few studies have evaluated the interrelations between hemoglobin and multiple iron status biomarkers in umbilical cord blood. A full understanding is needed of how these parameters influence each other within cord blood to fully interpret iron and hematologic status at birth. Read More

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http://dx.doi.org/10.1093/jn/nxy286DOI Listing
February 2019

High Hydrostatic Pressure Processing Better Preserves the Nutrient and Bioactive Compound Composition of Human Donor Milk.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.

Background: When mother's milk is insufficient, pasteurized human donor milk (DM) is the recommended supplement for hospitalized very-low-birth-weight infants. The current method of pasteurization (Holder, 62.5°C, 30 min) negatively affects heat-sensitive nutrients and bioactive proteins. Read More

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http://dx.doi.org/10.1093/jn/nxy302DOI Listing
February 2019

Substitution of Dietary Sulfur Amino Acids by DL-2-hydroxy-4-Methylthiobutyric Acid Increases Remethylation and Decreases Transsulfuration in Weaned Piglets.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Institute of Nutritional Physiology, Dummerstorf, Germany.

Background: DL-2-hydroxy-4-methylthiobutyric acid (DL-HMTBA), an L-methionine (L-Met) hydroxyl analogue, has been suggested to be a dietary L-Met source. How dietary DL-HMTBA compared with L-Met affects whole-body L-Met kinetics in growing individuals is unknown.

Objectives: We determined to what extent DL-HMTBA supplementation of an L-Met-deficient diet affects whole-body L-Met and L-cysteine (L-Cys) kinetics, protein synthesis (PS), and the L-Met incorporation rate in liver protein (L-MetInc) compared with L-Met and DL-Met supplementation in a piglet model. Read More

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http://dx.doi.org/10.1093/jn/nxy296DOI Listing
February 2019

Exposure to a Slightly Sweet Lipid-Based Nutrient Supplement During Early Life Does Not Increase the Preference for or Consumption of Sweet Foods and Beverages by 4-6-y-Old Ghanaian Preschool Children: Follow-up of a Randomized Controlled Trial.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Whether consuming sweet foods early in life affects sweet food preferences and consumption later in childhood is unknown.

Objective: We tested the hypothesis that exposure to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not increase preference for or consumption of sweet items at preschool age.

Methods: We followed up children who had participated in a randomized trial in Ghana in which LNS was provided to 1 group of women during pregnancy and 6 mo postpartum and to their infants from ages 6-18 mo (LNS group). Read More

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http://dx.doi.org/10.1093/jn/nxy293DOI Listing
February 2019

Arrest of Fetal Brain Development in ALG11-Congenital Disorder of Glycosylation.

Pediatr Neurol 2018 Dec 24. Epub 2018 Dec 24.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Background: Arrest of fetal brain development and the fetal brain disruption sequence describe a severe phenotype involving microcephaly, occipital bone prominence, and scalp rugae. Congenital disorders of glycosylation are a heterogeneous group of inherited disorders involved in glycoprotein and glycolipid biosynthesis, which can cause microcephaly and severe neurodevelopmental disability.

Methods: We report an example of fetal microcephaly diagnosed at 36 weeks' gestation with a history of normal fetal biometry at 20 weeks' gestation. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.009DOI Listing
December 2018

Human Fetal TNF-α-Cytokine-Producing CD4 Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Immunity 2019 Feb 5. Epub 2019 Feb 5.

Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg 20251, Germany. Electronic address:

Although the fetal immune system is considered tolerogenic, preterm infants can suffer from severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we demonstrate that human fetal intestines predominantly contain tumor necrosis factor-α (TNF-α)CD4CD69 T effector memory (Tem) cells. Single-cell RNA sequencing of fetal intestinal CD4 T cells showed a T helper 1 phenotype and expression of genes mediating epithelial growth and cell cycling. Read More

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http://dx.doi.org/10.1016/j.immuni.2018.12.010DOI Listing
February 2019

Expired Tidal Volume Variation in Extremely Low Birth Weight and Very Low Birth Weight Infants on Volume-Targeted Ventilation.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Section of Neonatology, Indiana University, Indianapolis, IN.

In a prospective study we describe the delivery of small tidal volumes to extremely low birth weight (ELBW) and very low birth weight (VLBW) infants using a volume-targeted ventilation mode (VTV). Tidal volume delivery was consistent for both ELBW and VLBW infants independent of gestational age, birth weight, and the target volume. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.053DOI Listing
February 2019

Hospital Variation in Child Protection Reports of Substance Exposed Infants.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, University of Washington School of Public Health, Seattle, WA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA; Harborview Injury Prevention & Research Center, University of Washington, Seattle, WA.

Objective: To examine whether hospital-level factors contribute to discrepancies in reporting to Child Protective Services (CPS) of infants diagnosed with prenatal substance exposure.

Study Design: We used a linked dataset of birth, hospital, and CPS records using diagnostic codes (International Classification of Diseases, Ninth Revision) to identify infants diagnosed with prenatal substance exposure. Using multilevel models, we examined hospital-level and individual birth-level factors in relation to a report to CPS among those infants prenatally exposed to substances. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.065DOI Listing
February 2019

The association between brain morphological development and the quality of general movements.

Brain Dev 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

Aim: To clarify the morphologic characteristics of the brain, which are the foundation of the emergence of general movements (GMs) in very-low-birth-weight infants.

Study Design: Prospective cohort study. GMs were scored according to a semiquantitative scoring system: the GMs optimality score (GMOS) at preterm and term ages. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.01.007DOI Listing
February 2019

Pilot Testing a Robot for Reducing Pain in Hospitalized Preterm Infants.

OTJR (Thorofare N J) 2019 Feb 15:1539449218825436. Epub 2019 Feb 15.

1 The University of British Columbia, Vancouver, Canada.

Optimizing neurodevelopment is a key goal of neonatal occupational therapy. In preterm infants, repeated procedural pain is associated with adverse effects on neurodevelopment long term. Calmer is a robot designed to reduce infant pain. Read More

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http://dx.doi.org/10.1177/1539449218825436DOI Listing
February 2019

Reply: "Letter to the Editor Re: Billeaud et al. 2018, , 690".

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Nestlé Nutrition R&D, 1800 Vevey, Switzerland.

We thank Bernard and colleagues for their careful reading and interest in our article [... Read More

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http://dx.doi.org/10.3390/nu11020406DOI Listing
February 2019

Biocatalysis of Fucodian in Sporophyll Using RD47 for Production of Prebiotic Fucosylated Oligosaccharide.

Mar Drugs 2019 Feb 14;17(2). Epub 2019 Feb 14.

Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea.

Fucosylated oligosaccharide (FO) is known to selectively promote the growth of probiotic bacteria and is currently marketed as a functional health food and prebiotic in infant formula. Despite widespread interest in FO among functional food customers, high production costs due to high raw material costs, especially those related to fucose, are a significant production issue. Therefore, several actions are required before efficient large-scale operations can occur, including (i) identification of inexpensive raw materials from which fucosylated oligosaccharides may be produced and (ii) development of production methods to which functional food consumers will not object (e. Read More

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http://dx.doi.org/10.3390/md17020117DOI Listing
February 2019

Physiological and clinical role of insulin in the neonate.

Expert Rev Endocrinol Metab 2010 Mar;5(2):197-207

c Department of Paediatrics, University of Cambridge, Box 116, Level 8, Addenbrooke's Hospital University Trust, Hills Road, Cambridge CB2 0QQ, UK.

In the newborn infant, insulin secretion has to adjust in response to the switch from a regulated and continuous placental supply of glucose in utero to the delivery of intermittent oral feeds postnatally. Changes in insulin secretion must reflect its primary role for maintaining glucose homeostasis, but also its roles in promoting growth and anabolism and in the newborn disorders of insulin secretion or sensitivity, which present with hyperglycemia and impaired growth. Recent elucidation of the genetic basis of neonatal diabetes has helped to provide valuable insights into the molecular mechanisms of β-cell function and the potential for treatment of some patients with oral hypoglycemic agents, although the majority require prolonged subcutaneous insulin treatment, which may prove challenging. Read More

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http://dx.doi.org/10.1586/eem.09.58DOI Listing

Are sensorimotor experiences the key for successful early intervention in infants with congenital brain lesion?

Infant Behav Dev 2019 Feb 12;54:133-139. Epub 2019 Feb 12.

Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark; DTU Compute, Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark.

Living with a congenital brain lesion may have detrimental effects on the ability to do everyday activities, but contrary to acquired brain lesions, people and in particular children, with congenital brain lesions may have limited or no experience of how their bodies work. This absence of experience gives rise to challenges for habilitation of sensorimotor abilities and derived cognitive abilities. How can motor and cognitive abilities be achieved and trained in an individual with no experience of potential abilities? In this article, we aim to review the existing knowledge about the development of sensorimotor integration. Read More

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http://dx.doi.org/10.1016/j.infbeh.2019.02.001DOI Listing
February 2019

Focused attention predicts visual working memory performance in 13-month-old infants: A pupillometric study.

Dev Cogn Neurosci 2019 Jan 24;36:100616. Epub 2019 Jan 24.

University of Massachusetts Boston, United States. Electronic address:

Attention turns looking, into seeing. Yet, little developmental research has examined the interface of attention and visual working memory (VWM), where what is seen is maintained for use in ongoing visual tasks. Using the task-evoked pupil response - a sensitive, real-time, involuntary measure of focused attention that has been shown to correlate with VWM performance in adults and older children - we examined the relationship between focused attention and VWM in 13-month-olds. Read More

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http://dx.doi.org/10.1016/j.dcn.2019.100616DOI Listing
January 2019

Infant removals: The need to address the over-representation of Aboriginal infants and community concerns of another 'stolen generation'.

Child Abuse Negl 2019 Feb 12;90:88-98. Epub 2019 Feb 12.

Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

Objectives: The removal of a child from their parents is traumatising, particularly in Aboriginal communities where a history of child removals has led to intergenerational trauma. This study will determine where disparities in child protection involvement exist among Aboriginal and non-Aboriginal children and characteristics associated with infant removals. Challenges faced by child protection and other agencies, and opportunities for overcoming these, are discussed. Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.01.017DOI Listing
February 2019

Geospatial analyses of adverse birth outcomes in Southwestern Ontario: Examining the impact of environmental factors.

Environ Res 2018 Dec 31;172:18-26. Epub 2018 Dec 31.

Department of Paediatrics, Western University, 800 Commissioners Road East, London, Ontario, Canada, N6A 5W9; Department of Epidemiology and Biostatistics, Western University, 1151 Richmond Street, London, Ontario, Canada, N6A 5C1; Children's Health Research Institute, 800 Commissioners Road East, London, Ontario, Canada, N6C 2V5; Lawson Health Research Institute, 750 Base Line Road East, London, Ontario, Canada, N6C 2R5; Human Environments Analysis Laboratory, Western University, 1151 Richmond Street, London, Ontario, Canada, N6A 3K7; Department of Geography, Western University, 1151 Richmond Street, London, Ontario, Canada, N6A 5C2; School of Health Studies, Western University, 1151 Richmond Street, London, Ontario, Canada, N6A 3K7. Electronic address:

Background: A growing body of research has examined the association between exposure to environmental factors during pregnancy and adverse birth outcomes; however, many studies do not control for potential covariates and findings vary considerably.

Objective: To test the relative influence of environmental factors including exposure to air pollution, major roads, highways, industry, parks, greenspaces, and food retailers on low birth weight (LBW) and preterm birth (PTB) in Southwestern Ontario (SWO), Canada, while accounting for medical (e.g. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.068DOI Listing
December 2018

Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse?

Free Radic Biol Med 2019 Feb 12. Epub 2019 Feb 12.

Division of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.

Preterm birth is a primary cause of worldwide childhood mortality. Bronchopulmonary dysplasia, characterized by impaired alveolar and lung vascular development, affects 25-50% of extremely low birth weight (BW; <1 kg) infants. Abnormalities in lung function persist into childhood in affected infants and are second only to asthma in terms of childhood respiratory disease healthcare costs. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.038DOI Listing
February 2019

Cholecystectomy During the Third Trimester of Pregnancy: Proceed or Delay?

J Am Coll Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Surgery, Massachusetts General Hospital, Boston, MA.

Background: Current guidelines suggest that cholecystectomy during the third trimester of pregnancy is safe for both the women and the fetus. However, no population-based study has examined this issue. The aim of this analysis was to compare the results of cholecystectomy during the third trimester of pregnancy with outcomes in women operated on in the early postpartum period in a large population. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.024DOI Listing
January 2019

[The polymorphism of detoxification genes system genes in very preterm infants.]

Klin Lab Diagn 2018 ;63(10):658-660

Federal State Budget Institution "Ivanovo research Institute of maternity and childhood named after V.N. Gorodkov" of the Ministry of health of the Russian Federation, Russia, 153000, Ivanovo.

his article is devoted to the comparative analysis of polymorphism of genes of the detoxification system in premature newborns with birth weight less than 1500 g and gestational age less than 32 weeks, formed bronchopulmonary dysplasia (BPD) (n=50), and without signs of BPD (n=47). A positive association between the presence in the genotype of deletion variants of glutathioneS-transferases (GSTT1 and GSTМ1) and risk of developing BPD in preterm infants. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-658-660DOI Listing
January 2018

Ultrasound Findings of Mammary Duct Ectasia Causing Bloody Nipple Discharge in Infancy and Childhood.

J Ultrasound Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Chonnam National University Hospital, Gwangju, Korea.

Bloody nipple discharge in infancy and childhood is extremely rare, and mammary duct ectasia is the most common etiology. Ultrasound (US) findings of mammary duct ectasia include dilated ducts and tubular anechoic lesions that may contain echogenic debris in the subareolar region. However, mammary duct ectasia may show variable US findings, which are not well described in the literature. Read More

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http://dx.doi.org/10.1002/jum.14970DOI Listing
February 2019

Age of Introduction of Complementary Feeding and Overweight in Adolescence and Adulthood: A Systematic Review.

Matern Child Nutr 2019 Feb 15:e12796. Epub 2019 Feb 15.

Department of Nutrition Sciences, Federal University of Bahia, Brazil.

Recent studies on early infant feeding suggest that the type of diet and age of starting complementary foods may have a positive correlation with overweight in adolescence and adulthood. This study aimed to systematically review the evidence on the relationship between the age of introduction of complementary feeding and excess weight in adolescence and adulthood. PROSPERO: CRD42017067764. Read More

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http://dx.doi.org/10.1111/mcn.12796DOI Listing
February 2019

High plasma soluble CD163 during infancy is a marker for neurocognitive outcomes in early treated HIV-infected children.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Global Health, University of Washington, Seattle, WA, USA.

Background: Monocyte activation may contribute to neuronal injury in aviremic HIV-infected adults; data are lacking in children. We examined the relation between monocyte activation markers and early and long-term neurodevelopmental outcomes in early-treated HIV-infected children.

Setting: Prospective study of infant and child neurodevelopmental outcomes nested within a randomized clinical trial (NCT00428116) and extended cohort study in Kenya. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001979DOI Listing
February 2019
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Maternal Depression and Stress in the NICU: Associations With Mother-Child Interactions at Age 5 Years.

J Am Acad Child Adolesc Psychiatry 2019 Jan 3. Epub 2019 Jan 3.

Washington University School of Medicine, St. Louis, MO.

Objective: Previous studies suggest that maternal postpartum mental health issues may impact parenting and child development in preterm infants, but have often not measured symptomatology in the Neonatal Intensive Care Unit (NICU) nor followed families through early childhood. This study examines how maternal depressive symptoms and stress in the NICU are related to parenting behaviors at age 5 years, in mothers of children born very preterm (≤30 weeks gestation).

Method: This longitudinal study followed a diverse sample of 74 very preterm children and their mothers. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.08.016DOI Listing
January 2019

Factors Impacting Practice of Home Kangaroo Mother Care with Low Birth Weight Infants Following Hospital Discharge.

J Trop Pediatr 2019 Feb 14. Epub 2019 Feb 14.

Save the Children, Health and Nutrition National Support Office, Gurgaon, Haryana, India.

Objective: To identify enablers and barriers related to home Kangaroo Mother Care (KMC) adoption after hospital discharge.

Study Design: An exploratory study, using a mixed methods evaluation, followed 60 mother-infant dyads from the hospital ward to 4 weeks post-hospital discharge.

Results: Fifty-three of the mothers (88. Read More

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http://dx.doi.org/10.1093/tropej/fmz007DOI Listing
February 2019

Prolonged Anesthetic Exposure in Children and Factors Associated With Exposure Duration.

J Neurosurg Anesthesiol 2019 Jan;31(1):134-139

Departments of Anesthesiology and Epidemiology, Columbia University College of Physicians and Surgeons and Mailman School of Public Health.

Introduction: Anesthetic exposure duration has come under scrutiny because of a Food and Drug Administration warning against prolonged use of anesthesia in children, defined as exposures longer than 3 hours.

Methods: Data for 2,613,344 pediatric anesthetic records from the American Society of Anesthesiologist's National Anesthesia Clinical Outcomes Registry from 2010 to 2015 were analyzed to describe anesthetic duration and the prevalence of prolonged exposures in children. Common pediatric inpatient procedures were independently assessed to determine factors associated with exposure duration. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000540DOI Listing
January 2019

Reaching Parents Through an Online Community.

J Neurosurg Anesthesiol 2019 Jan;31(1):122-124

Departments of Anesthesiology.

Scientific studies in animal models have demonstrated the neurotoxic effects of anesthetic and sedative drugs on the developing brain. Human studies, however, have been limited and less conclusive. The implications for clinical care remain unclear, and there is a critical need for further research on anesthetic toxicity to ensure safe anesthesia practices for infants and children. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000539DOI Listing
January 2019

SmartTots Outcomes Workshop 2017: Notes From a Round Table Discussion About Outcome Measures.

J Neurosurg Anesthesiol 2019 Jan;31(1):115-118

Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD.

An important element of designing research studies is the selection of appropriate outcome measures to ensure that the question posed is properly answered given the evidence. The selection of outcome measures is especially important when tackling complex, interdisciplinary problems, where appropriate outcome measures may not be as simple as a blood test or a laboratory value. One such area of study is the research into neurodevelopmental outcomes after early exposure to anesthetic agents. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000550DOI Listing
January 2019

Healthcare provider diagnostic testing practices for identification of Clostridioides (Clostridium) difficile in children: an Emerging Infections Network survey.

Infect Control Hosp Epidemiol 2019 Feb 15:1-5. Epub 2019 Feb 15.

Department of Internal Medicine,University of Iowa Carver College of Medicine,Iowa City, Iowa.

Objective: To characterize healthcare provider diagnostic testing practices for identifying Clostridioides (Clostridium) difficile infection (CDI) and asymptomatic carriage in children.

Design: Electronic survey.

Methods: An 11-question survey was sent by e-mail or facsimile to all pediatric infectious diseases (PID) members of the Infectious Diseases Society of America's Emerging Infections Network (EIN). Read More

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http://dx.doi.org/10.1017/ice.2018.347DOI Listing
February 2019

High- versus low-intensity interventions for perinatal depression delivered by non-specialist primary maternal care providers in Nigeria: cluster randomised controlled trial (the EXPONATE trial).

Br J Psychiatry 2019 Feb 15:1-8. Epub 2019 Feb 15.

Associate Professor,Division of Social and Transcultural Psychiatry,McGill University; andResearch Director,Department of Psychiatry,Jewish General Hospital,Canada.

Background: Contextually appropriate interventions delivered by primary maternal care providers (PMCPs) might be effective in reducing the treatment gap for perinatal depression.AimTo compare high-intensity treatment (HIT) with low-intensity treatment (LIT) for perinatal depression.

Method: Cluster randomised clinical trial, conducted in Ibadan, Nigeria between 18 June 2013 and 11 December 2015 in 29 maternal care clinics allocated by computed-generated random sequence (15 HIT; 14 LIT). Read More

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http://dx.doi.org/10.1192/bjp.2019.4DOI Listing
February 2019

Reproductive Health Outcomes in African Refugee Women: A Comparative Study.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

4 Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Background: African refugee women in the United States are at risk of poor reproductive health outcomes; however, examination of reproductive health outcomes in this population remains inadequate. We compared: (1) prepregnancy health and prenatal behavior; (2) prenatal history and prenatal care utilization; and (3) labor and birth outcomes between African refugee women and U.S. Read More

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http://dx.doi.org/10.1089/jwh.2018.7314DOI Listing
February 2019

Antenatal caregiving representations among expectant mothers with severe mental illness: a cross-sectional study.

J Reprod Infant Psychol 2019 Feb 15:1-14. Epub 2019 Feb 15.

a Department of Psychology , University of Copenhagen , Copenhagen , Denmark.

Objective: The study explores predictors of antenatal caregiving representations among mothers with a history of severe mental illness (SMI).

Background: Attachment research has demonstrated that multifactorial assessment of antenatal caregiving representations predicts later maternal behaviour and child attachment. However, the field lacks research among clinical groups. Read More

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http://dx.doi.org/10.1080/02646838.2019.1578868DOI Listing
February 2019

Dental Team's Role in Maternal and Child Oral Health During and After Pregnancy.

Compend Contin Educ Dent 2019 Feb;40(2):90-96; quiz 97

Associate Professor, Director, Predoctoral Pediatric Dentistry, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama.

For a mother-to-be, pregnancy presents an opportunity to improve not only her health and well being but also that of the immediate family, particularly the newborn infant. The National Consensus Statement of the Oral Health Care During Pregnancy Expert Group together with both governmental and non-governmental guidelines indicate that dental care is both safe and effective during pregnancy. These statements and guidelines may not be widely understood across all healthcare providers that form the perinatal care team, and confusion seems to exist among the general public regarding the safety of and necessity for dental care during pregnancy. Read More

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February 2019

[Social representations of epilepsy and therapeutic routes of parents of epileptic children in Abidjan].

Sante Publique 2018 September October;30(5):703-712

Purpose: The present study examines the influence of representations of childhood epilepsies in their generalized form on the therapy courses of parents seeking treatment for their epileptic children.

Methods: The approach used is retrospective, quantitative and qualitative. The data collection was done through the analysis of the medical records of 81 children diagnosed with epilepsy and treated at the Abidjan Infant Guidance Center over a period of 18 months (January 2015 to June 2016), and a semi-directive interview administered to their parents who came with them for their medical follow-up. Read More

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http://dx.doi.org/10.3917/spub.186.0703DOI Listing
February 2019

Predictors of breastfeeding non-initiation in the NICU.

Matern Child Nutr 2019 Feb 14:e12797. Epub 2019 Feb 14.

OB/GYN Department, University of Cincinnati, Cincinnati, OH, USA.

This study compared predictors of breastfeeding non-initiation between infants who were and were not admitted to the NICU so that interventions can target high-risk mothers whose infants desperately need breastmilk. This was a population-based retrospective cohort study of singleton Ohio live births using birth certificates, 2006-2015. In babies who were and were not admitted to the NICU, a multivariable logistic regression model assessed the association between breastfeeding non-initiation and predictors relating to the mother, neonate, and labor and delivery events while adjusting for covariables. Read More

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http://dx.doi.org/10.1111/mcn.12797DOI Listing
February 2019
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