5,698 results match your criteria Infantile Hemangioma


Congenital Disseminated Pyogenic Granuloma: Characterization of an Aggressive Multisystemic Disorder.

J Pediatr 2020 Jul 2. Epub 2020 Jul 2.

Division of Vascular and Interventional Radiology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Objective: To describe the clinical, radiological and histopathological features of "congenital disseminated pyogenic granuloma" (CDPG) involving various organs with high morbidity related to cerebral hemorrhagic involvement.

Study Design: We searched the database of the Vascular Anomalies Center at Boston Children's Hospital from 1999 to 2019 for patients diagnosed as having multiple vascular lesions, visceral vascular tumors, congenital hemangiomatosis, multiple pyogenic granulomas or multiple vascular lesions without a definite diagnosis. A retrospective review of the medical records, photographs, histopathological and imaging studies was performed. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.079DOI Listing

Successful Treatment of Infantile Hemangioma with High Risk of Severe Sequelae by Microneedle Radiofrequency.

Dermatol Ther 2020 Jul 2. Epub 2020 Jul 2.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.

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http://dx.doi.org/10.1111/dth.13953DOI Listing

Klippel-Trenaunay and Sturge-Weber Overlap Syndrome with KRAS and GNAQ mutations.

Ann Clin Transl Neurol 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, No.58 Zhongshan Road 2, Guangzhou, 510080, China.

Patients with combined phenotypes of Sturge-Weber syndrome and Klippel-Trenaunay syndrome have been reported, though the underlying genetic spectrum in these individuals remains to be elucidated. We reported the patient presenting with Klippel-Trenaunay and Sturge-Weber overlap syndrome in mainland China. Histopathologic study confirmed the hemangioma of vein and capillary. Read More

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http://dx.doi.org/10.1002/acn3.51106DOI Listing

Integrated propranolol, methylprednisolone, and surgery in managing a rare case of infantile hemangioma with concurrent cleft lip and palate.

Ann Med Surg (Lond) 2020 Aug 19;56:91-94. Epub 2020 Jun 19.

Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.

Infantile hemangioma (IH) with concurrent cleft lip and palate is a rare case. Surgical management is often considered as the best management for infantile hemangioma with concurrent cleft lip and palate. However, considering the functionality aspect and aesthetic appearance, a plastic surgeon can also consider non-surgical management without interrupting the surgical timeline for the cleft lip and palate. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322350PMC

Primary and secondary retinal capillary haemangioma in Mexico.

Arch Soc Esp Oftalmol 2020 Jun 26. Epub 2020 Jun 26.

Departamento de Retina y Vítreo, Fundación Hospital Nuestra Señora de la Luz, IAP, Ciudad de México, México.

A series is presented of 16 cases of retinal capillary haemangioma from consecutive patients at an ophthalmology teaching hospital in Mexico City. There were 7 primary haemangioblastomas, and 9 due to von Hippel-Lindau disease. All cases associated with this disease already had systemic manifestations, such as cerebellar, medullary and renal tumours. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.05.024DOI Listing

Diode laser-assisted management of intraoral soft tissue overgrowth: a case series.

Gen Dent 2020 Jul-Aug;68(4):28-31

The conventional method of managing intraoral soft tissue overgrowth involves surgical excision using a scalpel under local anesthesia. These procedures are often associated with excessive bleeding that leads to complications. Now, minimally invasive methods such as laser excision are available for the management of intraoral soft tissue lesions. Read More

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Mitochondria as Target for Tumor Management of Hemangioendothelioma.

Antioxid Redox Signal 2020 Jun 27. Epub 2020 Jun 27.

Indiana University School of Medicine, 12250, Surgery, MRLB Suite 454, 975 W Walnut Street, Indianapolis, Indiana, United States, 46202-5114;

Aims: Hemangioendothelioma (HE) may be benign or malignant. EOMA cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Read More

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http://dx.doi.org/10.1089/ars.2020.8059DOI Listing

Observation on the effects of 595- nm pulsed dye laser and 755- nm long-pulsed alexandrite laser on sequential therapy of infantile hemangioma.

J Cosmet Laser Ther 2020 Jun 26:1-6. Epub 2020 Jun 26.

Department of Dermatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou, Zhejiang, China.

Background: Infantile hemangioma (IH) can lead to severe complications. The 595-nm pulsed dye laser is poorly effective on thick and deep IH. Long-pulsed alexandrite laser has the proper wavelength of 755 nm and a relatively deep penetration. Read More

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http://dx.doi.org/10.1080/14764172.2020.1783452DOI Listing

[Differential diagnosis of papilledema and macular exudation-the exophytically growing juxtapapillary retinal capillary hemangioma].

Ophthalmologe 2020 Jun 23. Epub 2020 Jun 23.

Augenzentrum am St. Franziskus-Hospital, Hohenzollernring 74, 48145, Münster, Deutschland.

In a 38-year-old female patient, who had been treated for acute visual impairment and suspected optic neuritis with no organic evidence in the right eye, an exophytically growing juxtapapillary retinal capillary hemangioma was found. The benign tumor is a rare but important differential diagnosis in cases of papilledema and macular exudation. The treatment is difficult; various therapeutic concepts are discussed. Read More

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http://dx.doi.org/10.1007/s00347-020-01138-xDOI Listing

[A Case of Radiation Necrosis in the Right Occipital Lobe Accompanied with Massive Hemorrhage:Histopathological Analysis].

No Shinkei Geka 2020 Jun;48(6):541-546

Department of Neurosurgery, Japanese Red Cross Fukuoka Hospital.

Radiation necrosis with massive hemorrhage is a rare complication of radiotherapy. We report the case of a male patient who had undergone radiotherapy therapy 18 years earlier and presently underwent gamma knife radiosurgery for a metastatic brain tumor in his right occipital lobe. The patient showed aberrant behavior with left homonymous hemianopsia and a gradual deterioration of cognitive function after radiotherapy. Read More

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http://dx.doi.org/10.11477/mf.1436204225DOI Listing

Epidural angiolipoma with concomitant intradural extramedullary capillary hemangioma at the same spinal level: A case report.

Oncol Lett 2020 Jul 21;20(1):209-214. Epub 2020 Apr 21.

Department of Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Spinal epidural angiolipomas (SALs) and spinal intradural extramedullary capillary hemangiomas (SIECHs) are both types of rare benign tumor, and their pathogeneses appear to be associated. The present report is, to the best of our knowledge, the first case of spinal angiolipoma and intradural extramedullary capillary hemangioma occurring at the same spinal level. A 54 year-old male patient experienced two operations within four months due to the occurrence of SAL and one SIECH at the T3 level presenting with sudden paraplegia. Read More

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http://dx.doi.org/10.3892/ol.2020.11559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286118PMC

Diagnosis and treatment of periorbital infantile hemangiomas: Case series and literature review.

Int J Pediatr Otorhinolaryngol 2020 Jun 3;136:110157. Epub 2020 Jun 3.

Department of Plastic Surgery, Jinling Hospital, Nanjing School of Clinical Medicine, Bengbu Medical College, Nanjing, Jiangsu, 210002, China; Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, 210002, China. Electronic address:

Objective: Infantile hemangiomas (IHs) are the most common benign tumor in infancy. Periorbital IHs may lead to visual dysplasia so prompt and effective treatment should be adopted. In this study, we retrospectively analyzed the diagnosis and treatment of periorbital IHs treated in our clinic and give the strategy for clinical practice. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110157DOI Listing

Juxtapapillary Capillary Retinal Angioma and Epiretinal Membrane Management in a Monocular Patient with Von Hippel-Lindau Syndrome.

Retin Cases Brief Rep 2020 Jun 10. Epub 2020 Jun 10.

University Hospitals Eye Institute, Case Western Reserve University Cleveland, Ohio.

Purpose: To report a case of von Hippel-Lindau (VHL) syndrome in a monocular patient with progressive vision loss due to Juxtapapillary Capillary Retinal Angioma and epiretinal membrane (ERM).

Patient: We describe a 37-year-old white male patient with von Hippel-Lindau (VHL) syndrome who presented for retinal evaluation. The right eye was blind with NLP vision. Read More

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http://dx.doi.org/10.1097/ICB.0000000000001021DOI Listing

[Update on beta blockers in 2020].

Rev Med Interne 2020 Jun 9. Epub 2020 Jun 9.

Service de Cardiologie, CHRU et Université de Tours. Hôpital Trousseau, Avenue de la République - 37170 Chambray-lès-Tours, France. Electronic address:

Beta-blockers (BB) are an heterogenous set of molecules actively blocking β adrenergic receptors. Their pharmacological properties depend on their various effects on the adrenergic signalling. Although they are no longer a first-choice treatment in hypertensive patients, they remain a cornerstone of pharmacological strategy in several cardiovascular diseases such as stable angina, heart failure, arrythmia and aortic related connective diseases. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.04.007DOI Listing

Progressing eczematous dermatitis in an infantile hemangioma with minimal or arrested growth treated with tacrolimus ointment.

JAAD Case Rep 2020 Jun 4;6(6):572-573. Epub 2020 May 4.

Pediatric Dermatology Unit, Sultan Qaboos University Hospital, Muscat, Oman.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265063PMC

Relative frequency of oral focal reactive overgrowths: An institutional retrospective study.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):76-80. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Context: Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_350_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269285PMC

A Case of Consumptive Hypothyroidism in a 1-Month-Old Boy with Diffuse Infantile Hepatic Hemangiomas.

J Korean Med Sci 2020 Jun 8;35(22):e180. Epub 2020 Jun 8.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Consumptive hypothyroidism is a rare paraneoplastic syndrome characterized by excessive inactivation of the thyroid hormones due to increased type 3 iodothyronine deiodinase activity of tumors. We report the case of severe consumptive hypothyroidism in a 1-month-old boy with infantile hepatic hemangiomas who presented with cardiac failure and cholestasis. Diffuse infiltration of hepatic hemangiomas was detected on abdominal imaging studies, and thyroid function screening test revealed severe hypothyroidism, which necessitated the administration of higher-than-usual doses of levothyroxine for the normalization of thyroid function. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279942PMC

Compound Coherent Plane-Wave Ultrasound Imaging of Vascular Malformations of the Orbit.

Ophthalmic Plast Reconstr Surg 2020 Jun 4. Epub 2020 Jun 4.

Ophthalmic Plastic and Reconstructive, and Orbital Surgery Division, Department of Ophthalmology, New York Presbyterian Hospital, Columbia University Irving Medical Center, New York, New York, U.S.A.

Purpose: Prior color-flow Doppler ultrasound studies of the eye have been performed with systems that exceed US Food and Drug Administration permissible ophthalmic ultrasonic energy limits. The authors report a study of orbital vascular malformations using a novel, Food and Drug Administration compliant, ultrafast compound coherent plane-wave ultrasound device to produce power Doppler images.

Methods: Using a Verasonics Vantage 128 ultrasound engine and a user-developed MATLAB program with a 5-MHz linear-array probe, compound coherent plane-wave ultrasound data were collected on patients with orbital vascular malformations. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001732DOI Listing

Intravascular Lobular Capillary Hemangioma (Intravascular Pyogenic Granuloma): A Clinicopathologic Study of 40 Cases.

Am J Surg Pathol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

Intravascular lobular capillary hemangioma (ILCH), or intravascular pyogenic granuloma, is relatively rare and likely underrecognized. We reviewed all ILCH cases from our institution confirmed pathologically from 2006 to 2019. Immunostains for smooth muscle actin and Wilms tumor 1 were performed on all cases and prior immunohistochemical stains were reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001509DOI Listing

Imaging features of pathologically proven pediatric splenic masses.

Pediatr Radiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Splenic masses present a diagnostic challenge to radiologists and clinicians alike, with a relative paucity of data correlating radiologic findings to pathological diagnosis in the pediatric population. To illustrate splenic mass imaging findings and approximate lesion prevalence, we retrospectively reviewed all splenectomies and splenic biopsies for splenic masses at a single academic pediatric hospital over a 10-year period in patients 18 years and younger. A total of 31 splenic masses were analyzed. Read More

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http://dx.doi.org/10.1007/s00247-020-04692-3DOI Listing

A retrospective study of 2 or 3 mg/kg/day propranolol for infantile hemangioma.

Pediatr Int 2020 Jun 3;62(6):751-753. Epub 2020 Jun 3.

Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.1111/ped.14181DOI Listing

Benign neonatal hemangiomatosis with early regression of skin lesions: A case report and review of the published work.

J Dermatol 2020 Jun 3:e15413. Epub 2020 Jun 3.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

A 2-day-old Japanese male infant was referred to our outpatient clinic for multiple cutaneous hemangiomas present since birth. Physical examination revealed 14 small, well-circumscribed red papules, scattered over the head, face, dorsum of the right hand, trunk, lower extremities, buttocks and penis. Ultrasound examination revealed no evidence of visceral involvement. Read More

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http://dx.doi.org/10.1111/1346-8138.15413DOI Listing

Intranasal lobular capillary hemangioma: A series of five cases.

Respir Med Case Rep 2020 11;30:101073. Epub 2020 May 11.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Lobular capillary hemangiomas (LCH) are acquired benign vascular lesions of the skin and mucous membranes mostly affecting the head and neck region. Involvement of the nasal cavity is extremely rare and can manifest as epistaxis and nasal obstruction.

Case Series: In this case series, we present five cases of intranasal LCH. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236058PMC

Use of dermal fat grafts for treating anetoderma with lipoatrophy following involution of hemangiomas.

Pediatr Dermatol 2020 May 22. Epub 2020 May 22.

Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Infantile hemangioma (IH) is a benign vascular tumor that gradually involutes over several years. Rapidly involuting congenital hemangioma (RICH) is the relatively rare congenital vascular tumor that is fully grown at birth and does not undergo postnatal growth and involutes during the first year. However, after involution of both IH and RICH, some have severe sequelae, such as redundant skin or conspicuous scarring, requiring additional treatment. Read More

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http://dx.doi.org/10.1111/pde.14207DOI Listing

Aggressive growing of the infantile cavernous hemangioma of the calvaria: a case report and review of literature.

Childs Nerv Syst 2020 May 20. Epub 2020 May 20.

Department of Neurosurgery, Nagano Children's Hospital, 3100 Toyoshina, Azumino, 399-8288, Japan.

Introduction: Primary intraosseous cavernous hemangiomas of the skull are very rare in the pediatric age group and usually slow-growing tumors.

Case Report: We present a case of 5-month-old girl with a left occipital cavernous hemangioma that is rapidly growing. The subcutaneous occipital tiny mass was first noted at birth, and the lesion became rapidly enlarged in size and became soft for 3 months. Read More

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http://dx.doi.org/10.1007/s00381-020-04678-4DOI Listing

Infantile Hemangioma: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Infantile hemangiomas are the most common vascular tumors of infancy affecting up to 12% of infants by the first year of life.

Objective: To familiarize physicians with the natural history, clinical manifestations, diagnosis, and management of infantile hemangiomas.

Methods: A Pubmed search was conducted in November 2019 in Clinical Queries using the key term 'infantile hemangioma'. Read More

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http://dx.doi.org/10.2174/1573396316666200508100038DOI Listing

MRI-based texture analysis for differentiating pediatric craniofacial rhabdomyosarcoma from infantile hemangioma.

Eur Radiol 2020 May 8. Epub 2020 May 8.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Objectives: To evaluate the diagnostic performance of MRI texture analysis (TA) for differentiation of pediatric craniofacial rhabdomyosarcoma (RMS) from infantile hemangioma (IH).

Methods: This study included 15 patients with RMS and 42 patients with IH who underwent MRI before an invasive procedure. All patients had a solitary lesion. Read More

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http://dx.doi.org/10.1007/s00330-020-06908-4DOI Listing

Multimodal Imaging of a Case of Juxtapapillary Retinal Capillary Hemangioma.

Ophthalmol Retina 2020 05;4(5):544

Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal; Faculdade de Medicina, Universidade de Coimbra (FMUC), Coimbra, Portugal; Association for Biomedical Research and Innovation in Light and Imaging (AIBILI), Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.oret.2020.01.003DOI Listing

Histopathological analysis of biopsies of "peri-implant inflammatory lesions." Everything is not what it seems.

Clin Implant Dent Relat Res 2020 Jun 7;22(3):366-372. Epub 2020 May 7.

Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Peri-implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri-implant mucosa. There is little information about the histopathological analysis of these peri-implant inflammatory diseases. Read More

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http://dx.doi.org/10.1111/cid.12905DOI Listing

Change of serum cytokine profiles by propranolol treatment in patients with infantile hemangioma.

Drug Discov Ther 2020 ;14(2):89-92

Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

Infantile hemangioma is a benign cutaneous tumor, which sometimes rapidly enlarges, causes cosmetic problem, destroys normal tissue, and possibly threatens life. Dye lasers, steroid administration, and watchful waiting had been the treatment options for infantile hemangioma, but in recent years propranolol therapy has become available. The mechanism underlying the action of propranolol, however, is still unknown. Read More

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http://dx.doi.org/10.5582/ddt.2020.03014DOI Listing
January 2020

Giant Infantile Hepatic Hemangioma: Case Report and Surgical Technique.

Sisli Etfal Hastan Tip Bul 2020 25;54(1):108-112. Epub 2020 Mar 25.

Department of Pediatric Surgery, Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.

Infantile hepatic hemangioma is the most common liver tumor in children. The most common symptoms are mass in her stomach, anemia and heart failure. According to the findings of the patient, the treatment may vary from the clinical follow-up to liver transplantation. Read More

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http://dx.doi.org/10.14744/SEMB.2018.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192244PMC

Beta Blocker Therapy for Congenital Hepatic Arteriovenous Fistula in Two Neonates.

Front Pediatr 2020 21;8:163. Epub 2020 Apr 21.

Department of Pediatric Cardiology, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Hepatic arteriovenous fistula (HAVF) is an abnormal communication between the hepatic arteries and hepatic veins. This condition is treated mainly using interventional closure and surgery. However, these procedures are associated with many postoperative complications and high mortality. Read More

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http://dx.doi.org/10.3389/fped.2020.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186415PMC

Progressively increasing density of the solid center of a ground-glass nodule in a solitary pulmonary capillary hemangioma: A case report.

Pathol Int 2020 May 5. Epub 2020 May 5.

Department of Diagnostic Pathology, NTT Medical Center Tokyo, Tokyo, Japan.

Solitary pulmonary capillary hemangiomas (SPCHs) are recently recognized, rare benign lesions that form solitary nodules owing to capillary proliferation. These lesions are usually detected incidentally as small ground-glass nodules (GGNs) on computed tomography (CT), and progressively enlarge over time. The radiological distinction from peripheral lung cancers is particularly challenging. Read More

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http://dx.doi.org/10.1111/pin.12945DOI Listing

Lobular Capillary Hemangioma Originating From the Nasopharynx.

Ear Nose Throat J 2020 Apr 30:145561320922736. Epub 2020 Apr 30.

Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1177/0145561320922736DOI Listing

Pediatric dermatology emergencies.

Cutis 2020 03;105(3):132-136

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.

Many pediatric skin conditions can be safely monitored with minimal intervention, but certain skin conditions are emergent and require immediate attention and proper assessment of the neonate, infant, or child. We review the following pediatric dermatology emergencies so that clinicians can detect and accurately diagnose these conditions to avoid delayed treatment and considerable morbidity and mortality if missed: staphylococcal scalded skin syndrome (SSSS), impetigo, eczema herpeticum (EH), Langerhans cell histiocytosis (LCH), infantile hemangioma (IH), and IgA vasculitis. Read More

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Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.

Histol Histopathol 2020 Apr 24:18222. Epub 2020 Apr 24.

Department of Cell Biology and Histology, School of Medicine, Campus of International Excellence "Campus Mare Nostrum", IMIB-Arrixaca, University of Murcia, Murcia, Spain.

Intussusceptive angiogenesis (IA) is currently considered an important alternative and complementary form of sprouting angiogenesis (SA). Conversely, intussusceptive lymphangiogenesis (IL) is in an initial phase of study. We compare their morphofunctional characteristics, since many can be shared by both processes. Read More

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http://dx.doi.org/10.14670/HH-18-222DOI Listing

Small bowel racemose hemangioma complicated with obstruction and chronic anemia: A case report and review of literature.

World J Gastroenterol 2020 Apr;26(14):1674-1682

Department of Gastrointestinal Surgery, Weihai Central Hospital, Weihai 264200, Shandong Province, China.

Background: Gastrointestinal hemangiomas are rare benign tumors. According to the size of the affected vessels, hemangiomas are histologically classified into cavernous, capillary, or mixed-type tumors, with the cavernous type being the most common and racemose hemangiomas being very rare in the clinic. Melena of uncertain origin and anemia are the main clinical manifestations, and other presentations are rare. Read More

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http://dx.doi.org/10.3748/wjg.v26.i14.1674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167414PMC

Propranolol-resistant infantile hemangioma successfully treated with sirolimus.

Pediatr Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Department of Dermatology, Hospital Sant Joan de Deu, Barcelona, Spain.

Infantile hemangiomas are the most common benign vascular tumors in childhood. Propranolol is the first-line treatment for infantile hemangiomas, but failures may occur. Sirolimus, an mTOR inhibitor, is a promising drug for the treatment of vascular malformations and vascular tumors. Read More

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http://dx.doi.org/10.1111/pde.14163DOI Listing

Intracranial, Intra-parenchymal Capillary Hemangioma - Case Report.

NMC Case Rep J 2020 Apr 24;7(2):43-46. Epub 2020 Mar 24.

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Toyama, Japan.

We report a very rare case of intracranial capillary hemangioma. This 15-year-old girl complained of pulsating headache in the temple area that aggravated with change of body positions. This headache usually lasted for 5 min and resolved without any treatment. Read More

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http://dx.doi.org/10.2176/nmccrj.cr.2019-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162812PMC

Serum cytokine profiles in infants with infantile hemangiomas on oral propranolol treatment: VEGF and bFGF, potential biomarkers predicting clinical outcomes.

Pediatr Res 2020 Apr 20. Epub 2020 Apr 20.

Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.

Background: Oral propranolol has become first-line treatment for infantile hemangiomas (IHs). This study focused on identifying cytokines related to the biology of IH and early regression indicators of IH after propranolol treatment.

Methods: For inclusion, the patients had to be aged less than 1 year and have an IH with a largest diameter ≥2 cm. Read More

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http://dx.doi.org/10.1038/s41390-020-0862-1DOI Listing

Proliferating Infantile Hemangioma Tissues and Primary Cell Lines Express Markers Associated with Endothelial-to-Mesenchymal Transition.

Plast Reconstr Surg Glob Open 2020 Feb 11;8(2):e2598. Epub 2020 Feb 11.

Gillies McIndoe Research Institute, Newtown, Wellington, New Zealand.

Background: We have previously shown that the endothelium of the microvessels of infantile hemangioma (IH) exhibits a hemogenic endothelium phenotype and proposed its potential to give rise to mesenchymal stem cells, similar to the development of hematopoietic cells. This endothelial-to-mesenchymal transition (Endo-MT) process involves the acquisition of a migratory phenotype by the endothelial cells, similar to epithelial-to-mesenchymal transition that occurs during neural crest development. We hypothesized that proliferating IH expresses Endo-MT-associated proteins and investigated their expression at the mRNA, protein, and functional levels. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159972PMC
February 2020

Management of infantile hemangiomas during the COVID pandemic.

Pediatr Dermatol 2020 May 16;37(3):412-418. Epub 2020 May 16.

University of Minnesota, Minneapolis, Minnesota, USA.

The COVID-19 pandemic has caused significant shifts in patient care including a steep decline in ambulatory visits and a marked increase in the use of telemedicine. Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. For those requiring treatment, prompt initiation decreases morbidity and improves long-term outcomes. Read More

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http://dx.doi.org/10.1111/pde.14196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262142PMC

Limited Utility of Repeated Vital Sign Monitoring During Initiation of Oral Propranolol for Complicated Infantile Hemangioma.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

School of Medicine and Public Health, University of Wisconsin.

Background: Initial propranolol recommendations for infantile hemangioma published in 2013 were intended as provisional best practices to be updated as evidence-based data emerged.

Methods: A retrospective multicenter study was performed to evaluate utility of prolonged monitoring after first propranolol dose and escalation(s). Inclusion criteria included diagnosis of hemangioma requiring propranolol of ≥0. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.013DOI Listing

Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy.

Indian Pediatr 2020 Apr;57(4):366-368

Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Infantile hepatic hemangioma (IHH)-related consumptive hypothyroidism is rare and occurs as a result of excess thyroid hormone inactivating enzyme, type-3 iodothyronine deiodinase. We present an infant with IHH-related hypothyroidism, in whom treatment with propranolol led to regression of tumor and subsequent euthyroid status. Read More

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The histopathology of congenital hemangioma and its clinical correlations: a long-term follow-up study of 55 cases.

Histopathology 2020 Apr 12. Epub 2020 Apr 12.

Paris Descartes University, Sorbonne Paris Cité, 75005, Paris, France.

Aim: Congenital hemangiomas (CHs) can be subdivided into rapidly involuting, noninvoluting, and partially involuting subtypes (RICHs, NICHs and PICHs, respectively). During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. Given the rarity of CHs, the subtypes' histologic aspects and clinicopathological correlations have not been extensively characterized. Read More

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http://dx.doi.org/10.1111/his.14114DOI Listing

Giant placental chorioangioma followed by circulatory failure of the newborn and infantile hemangioma: Case report.

J Neonatal Perinatal Med 2020 ;13(1):135-138

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Placental chorioangioma (CA) is a benign placental tumor. No specific treatment is required for asymptomatic cases. We report a female infant born to a mother with giant placental CA. Read More

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http://dx.doi.org/10.3233/NPM-180118DOI Listing
January 2020

Three Distinct Vascular Anomalies Involving Skeletal Muscle: Simplifying the Approach for the General Radiologist.

Radiol Clin North Am 2020 May;58(3):603-618

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

Venous malformations and hemangiomas of the skeletal muscle are separate entities with different clinical presentation, histology, and imaging findings. Recent advances in the field of vascular anomalies and current efforts in the unification of terminology by the International Society for the Study of Vascular Anomalies are pivotal in understanding and differentiating intramuscular venous malformations and intramuscular capillary-type hemangioma. Fibroadipose vascular anomaly is another recently defined vascular anomaly affecting the skeletal muscle, with a distinct clinical presentation, histology, and imaging appearance. Read More

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http://dx.doi.org/10.1016/j.rcl.2020.01.005DOI Listing

Propranolol-induced hyperkalemia in the management of infantile hemangioma.

JAAD Case Rep 2020 Apr 25;6(4):359-361. Epub 2020 Mar 25.

Division of Pediatric Dermatology, Department of Pediatrics, King Abdullah Specialist Children's Hospital, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1016/j.jdcr.2020.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103665PMC