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    5022 results match your criteria Infantile Hemangioma

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    Effects of Propranolol on Neurodevelopmental Outcomes in Patients with Infantile Hemangioma: A Case-Control Study.
    Biomed Res Int 2018 25;2018:5821369. Epub 2018 Feb 25.
    Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs).

    Methods: Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Read More

    Mesenteric infantile hemangioma: diagnostic work-up.
    Quant Imaging Med Surg 2018 Mar;8(2):252-256
    Radiology Department, Santobono Hospital, Napoli, Italy.
    A very rare localization of infantile hemangioma (IH) is mesentery. It may manifest with intra-luminal or intra-peritoneal bleeding. Here there is the case of a 45-day-old infant, presenting with anemia and poor growth, subsequently referred to an uncommon hemangioma of the mesentery. Read More

    Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review.
    J Cutan Med Surg 2018 Apr 1:1203475418770570. Epub 2018 Apr 1.
    5 Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
    Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Read More

    PEDF/VEGF ratio plays a crucial role in the spontaneous regression of infant hemangioma and the therapeutic effect of propranolol.
    Cancer Sci 2018 Apr 17. Epub 2018 Apr 17.
    Program of Molecular Medicine Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, 510080, China.
    Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating the activation of the VEGF pathway, which is hyperactivated in IH. However, this treatment is reportedly ineffective for 10% of tumors, and 19% of patients relapse after propranolol treatment. Read More

    Oncosuppressors and Oncogenes: Role in Haemangioma Genesis and Potential for Therapeutic Targeting.
    Int J Mol Sci 2018 Apr 13;19(4). Epub 2018 Apr 13.
    Department of Physiology, Faculty of Health Sciences, University of Pretoria, 9 Botshelo Road, Pretoria 0007, South Africa.
    Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. Excessive neovessel formation is associated with various neoplasms such as infantile hemangiomas (IH). Read More

    Capillary hemangioma associated with dermal atrophy masquerading as a deep fungal infection.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
    Hemangiomas are benign vascular neoplasms which arise in early adulthood. Herein we present a 79-year-old woman with a hemangioma of the lower flank masquerading as a cutaneous manifestation of a systemic fungal infection upon initial histological analysis. Decreased elastin and collagen within the lesion likely accounted for the clumping and splaying of the capillaries into "hyphae-like" structures. Read More

    Treatment of Facial Infantile Hemangioma: Comparative Study Between Propranolol and Ethanolamine Oleate.
    J Craniofac Surg 2018 Apr 4. Epub 2018 Apr 4.
    Institute of Plastic and Craniofacial Surgery, SOBRAPAR Hospital, Campinas, Brazil.
    Background: Infantile hemangiomas (IH) are the most common benign vascular tumors in childhood. Approximately 10% to 15% of these tumors require drug or surgical intervention. There are many options for IH treatment, of which propranolol is currently considered the gold standard. Read More

    Nonepithelial Tumors and Tumor-like Lesions of the Skin and Subcutis in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207
    3 Department of Pathology, University of Virginia, Charlottesville, Virginia.
    This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors. Read More

    Analysis of Follicle-Stimulating Hormone Receptor in Infantile Hemangioma.
    Ann Plast Surg 2018 Apr;80(4 Suppl 4):S211-S213
    From the Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, Boston, MA.
    Introduction: The life cycle of infantile hemangioma (IH) and secretion of follicle-stimulating hormone (FSH) are identical. We previously have shown that IH contains the FSH receptor (FSHR). The purpose of this study was to identify which cell type(s) in IH expresses FSHR. Read More

    [Repurposing of betablockers in dermatology].
    Rev Med Suisse 2018 Mar;14(600):670-675
    Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.
    Betablockers are used for decades in the treatment of cardiovascular diseases. Recently, the repurposing of the wide spectrum betablocker propranolol revolutionized the infantile hemangioma management. Besides, betablockers have been shown to significantly improve the prognosis of melanoma patients. Read More

    Imaging and Pathologic findings of Hepatic Small Vessel Hemangioma.
    Curr Probl Diagn Radiol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Radiology University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:
    Hepatic small vessel hemangioma represents a distinct yet very rare pathologic entity of the liver. The entity has also been in the past referred to as adult capillary hemangioma of the liver and congenital noninvoluting hemangioma. Imaging findings are not definitive and biopsy or resection is ultimately necessary. Read More

    Cutaneous metastases of infantile choriocarcinoma can mimic infantile hemangioma both clinically and radiographically.
    Pediatr Radiol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Medical Imaging, Phoenix Children's Hospital, Phoenix, AZ, USA.
    Infantile metastatic choriocarcinoma is a rare tumor of placental origin that can be observed with or without maternal metastases. A single cutaneous mass may be the only clinically observed sign. Reports of imaging findings are scarce given the extreme rarity of the tumor, and the disease can be rapidly fatal in the absence of prompt diagnosis. Read More

    Safety Profile during Initiation of Propranolol for Treatment of Infantile Hemangiomas in an Ambulatory Day-Care Hospitalization Setting.
    J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.
    Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
    Background: Propranolol is the mainstay of treatment for infantile hemangioma. Despite its good safety profile, it is not risk-free. Guidelines for propranolol initiation and monitoring have been suggested, but protocols vary among practitioners. Read More

    [Benign aggressive vascular anomalies in children].
    Bull Cancer 2018 Mar 20. Epub 2018 Mar 20.
    Centre de référence des maladies rares de la peau d'origine génétique, hôpital Pellegrin-Enfants, centre hospitalier universitaire de Bordeaux, unité de dermatologie pédiatrique, 33076 Bordeaux cedex, France.
    Superficial vascular anomalies constitute a large group of malformative and tumoral conditions developed from all types of vessels. Vascular tumors are the result of cellular hyperplasia, whereas vascular malformations (VMs) are constituted of dysplastic vessels. The classification from International Society for the Study of Vascular Anomalies (ISSVA) is based on this pathogenic difference. Read More

    NDRG1 and FOXO1 regulate endothelial cell proliferation in infantile hemangioma.
    Exp Dermatol 2018 Mar 23. Epub 2018 Mar 23.
    Department of Plastic Surgery, Kyungpook National University, Daegu, Korea.
    The etiopathogenesis of infantile hemangioma has not been well understood, and it is accepted that angiogenic mediator dysregulation is the main contributor to the abnormal hemangioma capillary formation. The role of NDRG1, a hypoxia-inducible protein; FOXOs, which are tumor suppressor proteins; and the mTOR complex 2 pathway in infantile hemangioma have not been studied yet. The purpose of this study was to investigate NDRG1 and FOXO1 expression in the infantile hemangioma and the correlation of these proteins with proliferation and involution. Read More

    Angiographic optical coherence tomography imaging of hemangiomas and port wine birthmarks.
    Lasers Surg Med 2018 Mar 22. Epub 2018 Mar 22.
    Department of Dermatology, University of California, Irvine.
    Objectives: A current therapeutic challenge of vascular lesions is that they do not always respond effectively to laser treatment. Information on targeted vessels could potentially be used to guide laser treatments. Optical coherence tomography (OCT) is a useful tool for the non-invasive imaging of tissues, including skin hemangiomas and port wine birthmarks. Read More

    Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma.
    Am J Dermatopathol 2018 Apr;40(4):231-239
    Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.
    Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. Read More

    Competitive endogenous RNA networks: integrated analysis of non-coding RNA and mRNA expression profiles in infantile hemangioma.
    Oncotarget 2018 Feb 4;9(15):11948-11963. Epub 2018 Jan 4.
    Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China.
    Infantile hemangioma (IH) is the most common vascular tumour in infants. The pathogenesis of IH is complex and poorly understood. Therefore, achieving a deeper understanding of IH pathogenesis is of great importance. Read More

    Metastatic Choriocarcinoma Masquerading as a Congenital Glabellar Hemangioma.
    Pediatr Dev Pathol 2018 Jan 1:1093526618765039. Epub 2018 Jan 1.
    1 Department of Pathology and Laboratory Medicine, 14524 Phoenix Children's Hospital , Phoenix, Arizona.
    Infantile choriocarcinoma (ICC) is a rare, highly malignant form of gestational trophoblastic neoplasia. Rapid diagnosis and initiation of treatment are paramount in reaching a successful outcome. Patients with these tumors typically present with a triad of anemia, hepatomegaly, and precocious puberty. Read More

    Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management.
    Sci Rep 2018 Mar 9;8(1):4264. Epub 2018 Mar 9.
    Department of Pediatric Surgery, Chengdu Shangjin Nanhu Hospital, Chengdu, 611730, China.
    Currently, propranolol is the most preferred systemic therapy for problematic infantile hemangiomas (IHs). However, the side effects such as bronchial hyperreactivity may be intolerable. The aim of this study was to evaluate the frequency, risk factors and management of intolerable side effects (ISEs) during propranolol therapy. Read More

    A rare case of important and recurrent abnormal uterine bleeding in a post partum woman caused by cavernous hemangioma: a case report and review of literature.
    Pan Afr Med J 2017 10;28:130. Epub 2017 Oct 10.
    Department of Obstetrics and Gynecology, University Hospital of Yopougon, Abidjan, Ivory Coast.
    The cavernous hemangioma is a rare benign vascular tumor. About 50 cases of this disease were found in the literature over the last century and only 9 cases of cavernous hemangioma on the pregnant uterus were published it comes into cavernous or capillary form. The symptomatology is not unequivocal and when it occurs during pregnancy or postpartum, it causes life-threatening cataclysmic hemorrhage. Read More

    Enhanced rapamycin delivery to hemangiomas by lipid polymer nanoparticles coupled with anti-VEGFR antibody.
    Int J Mol Med 2018 Jun 28;41(6):3586-3596. Epub 2018 Feb 28.
    Department of Vascular Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
    The most common tumors in children are infantile hemangiomas which could cause morbidity and severe complications. The development of novel alternative drugs to treat infantile hemangiomas is necessary, since Hemangeol is the only US Food and Drug Administration-approved drug for infantile hemangiomas. However, Hemangeol has several disadvantages, including a high frequency of administration and adverse effects. Read More

    Promotion of Propranolol Delivery to Hemangiomas by Using Anti-VEGFR Antibody-Conjugated Poly(lactic-co-glycolic acid) Nanoparticles.
    J Biomed Nanotechnol 2017 Dec;13(12):1694-1705
    Infantile hemangiomas are the most common tumors affecting children. Although infantile hemangiomas are benign, they could result in morbidity and mortality. The only US Food and Drug Administration-approved drug for infantile hemangiomas is propranolol hydrochloride (Hemangeol™); however, its adverse effects and high frequency of administration hamper its clinical application. Read More

    A study of serum vascular endothelial growth factor in infantile hemangiomas.
    Indian J Dermatol Venereol Leprol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Dermatology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
    Background: Though infantile hemangiomas are the most common benign tumor of infancy, their etiopathogenesis is not fully understood. Some studies report a diagnostic role for vascular endothelial growth factor (VEGF), but such studies are lacking from India.

    Aims: To study the clinicoepidemiological profile of infantile hemangiomas, to estimate and compare the serum levels of VEGF in infantile hemangiomas and controls, and to determine correlations between serum levels of VEGF and growth characteristics of infantile hemangiomas. Read More

    Retin Cases Brief Rep 2018 Feb 19. Epub 2018 Feb 19.
    Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: The purpose of this study was to evaluate the safety and efficacy of intravitreal propranolol for the management of retinal capillary hemangioma in a patient with Von Hippel-Lindau.

    Methods: Two intravitreal injections of 50 μg/0.05 mL propranolol were administered 6 weeks apart in the left eye of a 26-year-old patient with bilateral multiple retinal capillary hemangiomas. Read More

    Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia.
    Dermatol Pract Concept 2018 Jan 31;8(1):28-32. Epub 2018 Jan 31.
    Department of Dermatology Acibadem University School of Medicine, Istanbul, Turkey.
    Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process.

    Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. Read More

    Venous outlet syndrome caused by capillary hemangioma of the subclavian vein.
    Asian Cardiovasc Thorac Ann 2018 Mar 14;26(3):224-226. Epub 2018 Feb 14.
    1 Thoracic Surgery Unit, University Hospital Careggi, Florence, Italy.
    We report a case of intravenous lobular capillary hemangioma in the subclavian vein, causing venous thoracic outlet syndrome. A 32-year-old woman was referred to our unit with facial and left arm oedema. Ultrasound evaluation, computed tomography and magnetic resonance imaging showed a hypervascular mass in the middle portion of the subclavian vein, with arrest of venous flow. Read More

    Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1α.
    Medicine (Baltimore) 2018 Feb;97(7):e9562
    Department of Pharmacology.
    Background: Curcumin has been used as an alternative medicine for the treatment of infantile hemangiomas (IHs); however, the mechanism underlying the effectiveness of curcumin in IHs remains largely unclear.

    Methods: In this study, we isolated primary human hemangioma endothelial cells (HemECs) from fresh surgical specimens of 3 patients. We treated HemECs by curcumin and investigated the alterations in proliferative and apoptotic signaling pathways with cell counting kit-8, flow cytometry, western blotting, immunofluorescence, and real-time polymerase chain reaction. Read More

    15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms and .
    Front Pharmacol 2018 30;9:25. Epub 2018 Jan 30.
    Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    Infantile hemangioma (IH) is a common and benign vascular neoplasms, which has a high incidence in children. Although IH is benign, some patients experience complications such as pain, functional impairment, and permanent disfigurement. Treatment options for IH include corticosteroids, surgery, vincristine, interferon or cyclophosphamide. Read More

    Hemangioma of the Hard Palate in an Elderly Patient as a Life-Threatening Surgical Emergency.
    J Craniofac Surg 2018 Feb 12. Epub 2018 Feb 12.
    Department of Otorhinolaryngology, Van Training and Research Hospital, Van, Turkey.
    Hemangiomas of the head and neck are common benign tumors usually in childhood. They are rarely seen in hard palate. The authors present a geriatric patient with abundant hemorrhage due to a capillary hemangioma of the hard palate. Read More

    A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis.
    Am J Med Genet A 2018 Apr 13;176(4):1015-1022. Epub 2018 Feb 13.
    Center for Craniofacial Research, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas.
    Tooth development is regulated by multiple genetic pathways, which ultimately drive the complex interactions between the oral epithelium and mesenchyme. Disruptions at any time point during this process may lead to failure of tooth development, also known as tooth agenesis (TA). TA is a common craniofacial abnormality in humans and represents the failure to develop one or more permanent teeth. Read More

    Topical timolol for an iris hemangioma.
    J AAPOS 2018 Apr 20;22(2):156-158. Epub 2018 Mar 20.
    University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; Pediatric Ophthalmology, Children's Mercy Hospital, Kansas City, Missouri. Electronic address:
    Extraocular infantile hemangiomas have been shown to respond to oral and topical beta blockers, while there is little literature regarding the management of intraocular infantile hemangiomas with beta blockers. This case report discusses the management of an iris hemangioma with topical timolol, a treatment previously unreported in the literature. Read More

    Selective hemangioma cell dysfunction and apoptosis triggered by in vitro treatment with imiquimod.
    Toxicol Lett 2018 May 2;288:82-88. Epub 2018 Feb 2.
    Laboratorio de Biología Tumoral, Dpto. de Química Biológica IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address:
    Infantile hemangiomas are the most common benign tumors of infancy, characterized by unregulated angiogenesis and endothelial cells with high mitotic rate. Although spontaneous regression occurs, sometimes treatment is required and alternatives to corticosteroids should be considered to reduce side effects. Imiquimod is an imidazoquinoline, approved for some skin pathologies other than hemangioma. Read More

    Factors associated with delayed referral for infantile hemangioma necessitating propranolol.
    J Eur Acad Dermatol Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Reference Centre for Rare Skin Diseases, Dermatology Department, CHU Larrey, Paul Sabatier University, Toulouse, France.
    Background: Oral propranolol is the gold standard to treat infantile hemangiomas. There is better efficacy and a lower risk of sequelae if therapy is started before the end of the growth phase, but most children are referred too late. Herein, we report the first study to investigate the delay and its associated factors when referring infants with infantile hemangiomas that need propranolol therapy. Read More

    A Rare Cause of Hemoptysis in Childhood: Tracheal Capillary Hemangioma.
    Turk Thorac J 2017 Oct 21;18(4):131-133. Epub 2017 Jul 21.
    Clinic of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey.
    Hemangiomas are benign tumors most frequently seen in childhood and are mostly associated with cutaneous and mucosal surfaces. Tracheal capillary hemangiomas are extremely rare. The most common presenting symptom is hemoptysis, ranging from minor to major and chronic cough. Read More

    Conjunctival Capillary Hemangioma.
    Cureus 2017 Nov 29;9(11):e1892. Epub 2017 Nov 29.
    Pathology, Hofstra Northwell School of Medicine.
    Conjunctival hemangioma over the age of 60 is rare, with few cases reported in the literature. We present a unique case of a conjunctival capillary hemangioma, adding to the sparse literature of this uncommon vascular tumor. Here, we present an interesting case of spontaneous development of this tumor at age 68, without associated systemic disease process or cutaneous manifestations. Read More

    Current perspectives on the optimal management of infantile hemangioma.
    Pediatric Health Med Ther 2017 6;8:107-116. Epub 2017 Dec 6.
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Infantile hemangiomas (IHs) are the most common benign tumor of infancy. As our understanding of their pathobiology has evolved, treatment has become more focused and tailored to specifically treat IH while minimizing adverse effects. Propranolol has gained FDA approval as the first medical therapy for a traditionally surgical disease. Read More

    Co-existing infantile hepatic hemangioma and mesenchymal hamartoma in a neonate.
    J Surg Case Rep 2018 Jan 23;2018(1):rjx260. Epub 2018 Jan 23.
    Department of Pediatric Surgery, CHRU Nancy, 54500 Vandoeuvre-lès-Nancy, France.
    Infantile hepatic hemangioma (IHH) and mesenchymal hamartoma (MH) form the first and second most common benign hepatic tumors in children. In this case report, we present a newborn child in whom a growing hepatic mass was discovered at the age of 7 days. She suffered also from anemia, respiratory and renal failure. Read More

    Over-expression of PPAR-γ2 gene enhances the adipogenic differentiation of hemangioma-derived mesenchymal stem cells and .
    Oncotarget 2017 Dec 26;8(70):115817-115828. Epub 2017 Dec 26.
    Department of Plastic Surgery, Children's Hospital, Nanjing, Jiangsu 210008, China.
    Background: Most of infantile hemangiomas involute into fibrofatty tissue in childhood, which indicates adipogenesis during this period. Mesenchymal stem cells (MSCs) contribute to the adipogenesis in IH. In this study, we investigated the effects of overexpression of PPAR-γ2 gene on the adipogenic differentiation of Hemangioma-derived MSCs (Hem-MSCs), and discussed the possibility of targeted therapy via PPAR-γ pathway. Read More

    Vascular Ehlers-Danlos syndrome with cryptorchidism, recurrent pneumothorax, and pulmonary capillary hemangiomatosis-like foci: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8853
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University School of Medicine.
    Rationale: Vascular Ehlers-Danlos syndrome (vEDS) is a rare autosomal dominant inherited collagen disorder caused by defects or deficiency of pro-alpha 1 chain of type III procollagen encoded by COL3A1. vEDS is characterized not only by soft tissue manifestations including hyperextensibility of skin and joint hypermobility but also by early mortality due to rupture of arteries or vital organs. Although pulmonary complications are not common, vEDS cases complicated by pneumothorax, hemothorax, or intrapulmonary hematoma have been reported. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis.
    Arch Dermatol Res 2018 Jan 23. Epub 2018 Jan 23.
    The Children's Hospital, Zhejiang University School of Medicine, No. 3333 Binsheng Road, Hangzhou, 310052, Zhejiang, China.
    A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results. The present study assessed the response rate and adverse events of topical timolol in the treatment of infantile hemangioma. Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and Cochrane library were searched until October 2016. Read More

    Screening for Brain Involvement in Infants with Multifocal Cutaneous Infantile Hemangiomas.
    Dermatology 2017 20;233(6):435-440. Epub 2018 Jan 20.
    Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
    Background: Multifocal (≥5) infantile hemangiomas (IHs) are known as a risk factor for extracutaneous involvement. Liver is the most commonly involved organ, but involvement of other systems has also been reported. This study aims to describe the characteristic findings in a group of infants with multiple cutaneous hemangiomas, with emphasis on intracranial involvement. Read More

    [Clinical and imaging features of pulmonary veno-occlusive disease and pulmonary capillary hemangioma].
    Zhonghua Jie He He Hu Xi Za Zhi 2018 Jan;41(1):41-46
    Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medice, Shanghai 200433, China.
    To improve the diagnosis and treatment of the pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangioma (PCH). The clinical features, radiological findings, laboratory testing and treatment in 8 cases of PVOD/PCH which was diagnosed from 2013 to 2017 were described. PVOD/PCH was rare. Read More

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