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    When to stop propranolol for infantile hemangioma.
    Sci Rep 2017 Feb 22;7:43292. Epub 2017 Feb 22.
    From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
    There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Read More

    Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features.
    Eye (Lond) 2017 Feb 17. Epub 2017 Feb 17.
    Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
    AimTo describe the vascular features of choroidal tumors using enhanced depth imaging (EDI), optical coherence tomography (OCT), and OCT-angiography.MethodsIn this prospective study, we evaluated 116 Caucasian patients with choroidal tumors (60 eyes with choroidal nevi, 40 with choroidal melanoma, 6 with choroidal hemangioma, 2 with optic disc melanocytoma, 6 with choroidal osteoma, and 2 with retinal metastases). Patients underwent a complete ophthalmic examination including bulbar echography, EDI-OCT, OCT-angiography, and multicolor imaging. Read More

    Zygomatic Intraosseous Hemangioma: Case Report and Literature Review.
    Craniomaxillofac Trauma Reconstr 2017 Mar 4;10(1):1-10. Epub 2016 Nov 4.
    Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Intraosseous hemangiomas are uncommon intrabony lesions, representing approximately 0.5 to 1% of all intraosseous tumors. Their description varies from "benign vasoformative neoplasms" to true hamartomatous proliferations of endothelial cells forming a vascular network with intermixed fibrous connective tissue stroma. Read More

    The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma.
    Arch Dermatol Res 2017 Feb 14. Epub 2017 Feb 14.
    Plastic Surgery Department of Affiliated Fujian Union Hospital of Fujian Medical University, No.29, Xinquan Road, Fuzhou, 350001, Fujian, China.
    In previous studies, the expression and the role of proangiogenic factors in infantile hemangiomas have been well studied. However, the role of angiogenic inhibitors has been revealed rarely. The expression of PEDF, as the strongest and safe endogenous inhibitor, is still unrecognized until the current study. Read More

    Capillary Hemangioma of Thoracic Spinal Cord: PET/CT and MR Findings.
    Clin Nucl Med 2017 Feb 13. Epub 2017 Feb 13.
    From the Departments of *Nuclear Medicine, and †Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Capillary hemangiomas are frequently encountered superficially in the cutaneous, subcutaneous, or mucosal tissues during the childhood and early adulthood, but the occurrence of spinal intradural capillary hemangioma is relatively rare. Herein, we report a case with capillary hemangioma of the thoracic spine. MR and PET/CT features of this lesion are presented, and awareness of this entity may help differentiate it from other spinal intradural tumors. Read More

    Prospective, open-label, rater-blinded and self-controlled pilot study of the treatment of proliferating superficial infantile hemangiomas with 0.5% topical timolol cream versus 595-nm pulsed dye laser.
    J Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Topical timolol and 595-nm pulsed dye laser (PDL) are both widely used in the treatment of superficial infantile hemangiomas (IH). However, to date, there is no reliable study comparing the therapeutic outcomes between the two treatment options. We designed the present study to evaluate and compare the efficacy and safety of timolol cream and PDL in the treatment of superficial proliferating IH. Read More

    Propranolol treatment of infantile hemangioma is not associated with psychological problems at 7 years of age.
    J Am Acad Dermatol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Dermatology, Radboud University Medical Centre, and the Radboudumc Expertise-Centre for Hemangioma, Nijmegen, The Netherlands; Vascular Anomalies (Hecovan), Nijmegen, The Netherlands.
    Background: Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH).

    Objectives: We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH.

    Methods: Twenty-seven patients with IH (6. Read More

    The Possible Role of Endoscopy in Diagnosis of Benign Tumors of the Nasal Cavity.
    J Craniofac Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
    Background: Benign tumors of the nasal cavity represent a large variety of different histopathological entities. Although advances in nasal endoscopy over the past couple of decades have made it possible to detect the vast majority of these lesions, accurate diagnosis and proper management can be delayed since they are misdiagnosed as inflammatory paranasal sinus disease or simple epistaxis.

    Objectives: The aims of the present study are to determine the relative incidence of benign tumor of the nasal cavity and to provide typical endoscopic features of common tumors. Read More

    21 cases reports on haemangioma of spleen.
    J Cancer Res Ther 2016 Oct-Dec;12(4):1323
    Biomedical Engineering Center, Beijing University of Technology, Beijing, China.
    The growing activity of hemangioma of spleen keeps unknown. To search theoretical basis for whether to take the operation, this study analyzed clinical data of 21 hemangioma patients, and 16 surgical specimens were analyzed immunohistochemistry of Ki-67, Bcl-2 and vascular endothelial growth factor (VEGF). Both 14 cases of cavernous hemangioma were positive for VEGF, and negative in capillary hemangioma, there was statistical significant difference between two types of hemangioma (P < 0. Read More

    Small infantile hemangioma and breast hypoplasia.
    J Eur Acad Dermatol Venereol 2017 Feb 6. Epub 2017 Feb 6.
    Clinique Dermatologique, Faculté de Médecine, Université de Strasbourg et Hôpitaux Universitaires de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg, France.
    Large and/or segmental infantile hemangiomas (IH) are sometimes associated with other localized and/or more widespread malformations such as those occurring in the PHACES (1). Breast hypoplasia occurring after IH has been barely reported (2). We report the case of a small IH of the breast, associated with a homolateral breast hypoplasia and we raise the question of a potential link between the 2 findings. Read More

    Rare cause for hemoptysis in an adolescent: Bronchial capillary hemangioma.
    Pediatr Pulmonol 2017 Feb 6. Epub 2017 Feb 6.
    Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics, University Hospital Heidelberg, Heidelberg, Germany.
    Hemoptysis is rare in children and adolescents. We describe an 11-year-old girl who presented with hemoptysis, cough, and exertional dyspnea. Radiologic and bronchoscopic assessment revealed a pedunculated mass in the right main stem bronchus with a ball valve effect. Read More

    Sinonasal Hemangioma: Diagnosis, Treatment, and Follow-Up of 37 Patients at a Single Center.
    J Oral Maxillofac Surg 2017 Jan 5. Epub 2017 Jan 5.
    Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University, Jeonju, Korea; and Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Electronic address:
    Purpose: Hemangioma is a common benign vascular lesion of the head and neck region. It rarely involves the mucous membranes of the nasal cavity and paranasal sinuses. It should be added to the differential diagnosis of nasal cavity masses when the presenting symptoms are epistaxis or nasal obstruction. Read More

    Scalloping Characteristics in a Patient with Extra-Cranial Hemangioma.
    Pol J Radiol 2017 9;82:17-18. Epub 2017 Jan 9.
    Department of Radiology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India.
    Infantile hemangiomas are the most common benign tumors of infancy and childhood with a reported incidence of 4% to 10% in infants. We report of a 9 year-old male child with a history of progressively increasing swelling over the right eyebrow region. The lesion was present since childhood; however, it increased in in size over the previous 3-4 months. Read More

    Successful Treatment of Infantile Hemangiomas With Propranolol in Low-Birth-Weight Infants.
    J Craniofac Surg 2017 Jan 30. Epub 2017 Jan 30.
    *Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo †Department of Plastic and Reconstructive Surgery, Juntendo University Urayasu Hospital, Chiba ‡Department of Plastic and Reconstructive Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
    Background: Infantile hemangioma (IH) is a benign neoplasm that causes scarring and cosmetic problems after spontaneous regression. Therefore, aggressive treatments such as laser irradiation and corticosteroid have been used; however, recently, the effect of propranolol has been widely noticed. In this study, the authors applied propranolol to low-birth-weight infants with IHs and evaluated its effect. Read More

    Vulvar Lobular Capillary Hemangioma: A Rare Location for a Frequent Entity.
    Case Rep Obstet Gynecol 2016 29;2016:3435270. Epub 2016 Dec 29.
    Department of Pathologic Anatomy, Dr. Nélio Mendonça Hospital, Av. Luís de Camões, Funchal, 9004-514 Madeira Island, Portugal.
    Lobular capillary hemangioma, or pyogenic granuloma, is an acquired hemorrhagic benign vascular lesion of the skin and mucous membranes. The pyogenic granuloma of the vulva is a rare finding and a limited number of case reports are available in the literature. To the best of our knowledge this is the first case described as a single pyogenic granuloma on the vulva. Read More

    Subcutaneous Lobular Capillary Hemangioma on 68Ga-PSMA PET/CT.
    Clin Nucl Med 2017 Jan 20. Epub 2017 Jan 20.
    From the Departments of *Nuclear Medicine & PET Centre, and †Pathology, Aarhus University Hospital, Aarhus, Denmark.
    We present a case of a subcutaneous process in the abdominal wall with high prostate-specific membrane antigen (PSMA) activity on Ga-PSMA PET/CT. Histology demonstrated a benign lobular capillary hemangioma with a high vascular density, with highly PSMA-positive endothelial cells. It is well known that PSMA is expressed in different tissue, including neovasculature in various malignant tumors, and the knowledge is rapidly evolving as new discoveries appear. Read More

    Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway.
    Int J Mol Med 2017 Mar 20;39(3):757-763. Epub 2017 Jan 20.
    Department of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.
    Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. Read More

    Benign vascular lesions of the lips: Diagnostic approach.
    J Cutan Pathol 2017 Jan 23. Epub 2017 Jan 23.
    School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
    Background: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service.

    Methods: Among 5600 biopsies, 131 cases were found. Read More

    Primary mesenchymal liver tumors of childhood.
    Semin Diagn Pathol 2016 Dec 23. Epub 2016 Dec 23.
    Indiana University School of Medicine, United States. Electronic address:
    Primary mesenchymal tumors of the liver represent a significant proportion of liver tumors among neonates, infants and young children. They may be discovered incidentally or present with an alarmingly large, rapidly growing abdominal mass. One third of pediatric liver tumors are benign with hemangioma and mesenchymal hamartoma being the commonest in that order. Read More

    Capillary Hemangioma of the Tympanic Membrane and External Auditory Canal.
    J Craniofac Surg 2017 Jan 18. Epub 2017 Jan 18.
    Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
    Hemangiomas are very common tumors characterized by large numbers of vessels filled with blood. Capillary hemangioma is the most common type of hemangioma, whereas capillary hemangiomas of the tympanic membrane and external auditory canal are extremely rare vascular tumors. Here, the authors present capillary hemangioma of the tympanic membrane and external auditory canal in a 54-year-old woman with right-sided aural fullness for 3 months. Read More

    Klippel-Trenaunay and Sturge-Weber overlapping syndrome in a Saudi boy.
    Sudan J Paediatr 2016 ;16(2):86-92
    Division of Pediatric Neurology, Department of Pediatrics, College of Medicine and King Saud University Medical City , King Saud University, Riyadh , Saudi Arabia.
    Sturge-Weber Syndrome (SWS) is a rare, sporadic neurocutaneous disorder. It is typically characterized by unilateral, posterior leptomeningeal angiomas that calcify, glaucoma, and facial portwine tains. Klippel-Trenaunay syndrome (KTS) is a rare congenital syndrome characterized by ipsilateral cutaneous capillary malformations, venous varicosities, and bony or soft tissue overgrowth of the affected limbs. Read More

    Infantile Intraosseous Maxillary Hemangioma.
    Indian Pediatr 2016 Dec;53(12):1103-1104
    Departments of Otorhinolaryngology and Head and Neck Surgery, and *Pathology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. Correspondence to: Dr Divya Gupta, Department of Otolaryngology and Head and Neck Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.
    Background: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare.

    Case Characteristics: 1- month-old full term boy with maxillary swelling. Read More

    Anastomosing Hemangioma of the Ovary: A Clinicopathological Study of Six Cases with Stromal Luteinization.
    Pathol Oncol Res 2017 Jan 3. Epub 2017 Jan 3.
    Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic.
    We report six cases of anastomosing hemangioma of the ovary. All lesions were unilateral and arose in 43 to 81 year old females. In all but one patient, the tumor was asymptomatic and represented incidental finding. Read More

    Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.
    Matrix Biol 2016 Dec 20. Epub 2016 Dec 20.
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United States; Department of Oral and Maxillofacial Surgery/Skeletal Biology Research Center, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA, United States. Electronic address:
    Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling. Here, based on studies of primary fibroblasts isolated from skin of Antx1+/+ and Antxr1-/- mice at embryonic stage E17.5 and postnatal day P49, we conclude that increased Col1a1 and Fn1 expression in Antxr1-deficient fibroblasts is partly mediated by a cell-autonomous ANTXR1-dependent mechanism. Read More

    Immunolocalization of substance P and NK-1 receptor in vascular anomalies.
    Arch Dermatol Res 2017 Mar 17;309(2):97-102. Epub 2016 Dec 17.
    Research Laboratory on Neuropeptides, Biomedicine Institute, Virgen del Rocio, University Hospital, Avda. Manuel Siurot s/n, 41013, Seville, Spain.
    The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also ubiquitous in the human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates tumoral angiogenesis and proliferation. Thus, knowledge of this system is the key for a better understanding and, hence, a better management of many human diseases, including vascular anomalies (VA). Read More

    Utility of the Hemangioma Severity Scale as a Triage Tool and Predictor of Need for Treatment.
    Pediatr Dermatol 2017 Jan 16;34(1):78-83. Epub 2016 Dec 16.
    Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana.
    Background/objectives: Infantile hemangiomas (IHs) are commonly encountered in primary care and most often remain asymptomatic, resolving without sequelae. Certain characteristics are associated with a greater risk of complications, associated anomalies, and disfigurement. The heterogeneous presentation poses a clinical challenge for physicians in determining the need for treatment and subspecialty referral. Read More

    Myeloid Sarcoma in the Orbit.
    J Pediatr Ophthalmol Strabismus 2016 Dec 8;53:e64-e68. Epub 2016 Dec 8.
    The authors describe a case of myeloid sarcoma of the orbit in a pediatric patient. An 8-month-old male infant presented to the ophthalmology clinic with a left orbital mass, which had been increasing in size over the previous 2 months. The mass was initially diagnosed at another clinic as an infantile hemangioma, and had been treated with a topical formulation of timolol. Read More

    Inheritance Patterns of Infantile Hemangioma.
    Pediatrics 2016 Nov 12;138(5). Epub 2016 Oct 12.
    Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    Background And Objective: Infantile hemangioma (IH) includes, among its other risk factors, familial clustering, but a definitive understanding of IH's inheritance model and genetic basis is lacking. Our objective was to collect IH pedigrees in Finland, to study the inheritance patterns of IH within these families, and to analyze the characteristics of familial IHs.

    Methods: We identified 185 patients with IH who visited our vascular anomaly clinic between 2004 and 2007. Read More

    Retin Cases Brief Rep 2016 Dec 7. Epub 2016 Dec 7.
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
    Purpose: To present a self-peeling epiretinal membrane (ERM) in a patient with spontaneously improved retinal capillary hemangioma in the left eye.

    Methods: We demonstrate the improvement of an untreated retinal capillary hemangioma and resolution of ERM with fundus photography, fluorescein angiography, and spectral domain optical coherence tomography. Genetic testing excluded von Hippel-Lindau disease in this patient. Read More

    Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway.
    Biomed Pharmacother 2017 Jan 30;85:272-279. Epub 2016 Nov 30.
    Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355, Luding Road, Shanghai 200062, People's Republic of China. Electronic address:
    FABP4 is widely expressed in both normal and pathologic tissues. It promotes cell proliferation, survival and migration of endothelial cells, and therefore, angiogenesis. However, the role of FABP4 in hemangioma or hemangioma endothelial cells (HemECs) has not been explored. Read More

    Lobular capillary hemangioma of the tracheobronchial tree: A case report and literature review.
    Medicine (Baltimore) 2016 Nov;95(48):e5499
    aDepartment of Pulmonary Diseases, Beijing Tian Tan Hospital, Capital Medical University, Beijing bDepartment of Clinical Chemistry, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai cDepartment of Pathology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
    Rationale: Lobular capillary hemangioma (LCH) of the tracheobronchial tree is a rare benign tumor, whose characteristics and treatments remain relatively unknown.

    Patient Concerns: A 39-year-old man with hemoptysis caused by neoplasm in the bronchus intermedius was admitted to our hospital.

    Diagnoses: The patient was diagnosed with LCH. Read More

    Excellent response of infantile orbital hemangioma to propranolol.
    Int Med Case Rep J 2016 17;9:369-371. Epub 2016 Nov 17.
    Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.
    Infantile hemangiomas are the most common vascular neoplasm that present in infancy, with more than half affecting the head and neck region. Periocularly, hemangiomas may be complicated by visual loss through induction of strabismal, deprivational, or anisometropic astigmatism. We report a case of a 5-year-old girl who presented with orbital hemangioma with potential risk of visual loss who had excellent response to propranolol. Read More

    Infantile Hemangioma with Minimal or Arrested Growth: Further Observations on Clinical and Histopathologic Findings of this Unique but Underrecognized Entity.
    Pediatr Dermatol 2017 Jan 22;34(1):64-71. Epub 2016 Nov 22.
    Director of Laser Unit, Royal Children's Hospital, Melbourne, Victoria, Australia.
    Background: Infantile hemangioma (IH) with minimal or arrested growth (IH-MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if PHACE (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge-Weber syndrome is suspected. Although the clinical and histologic characteristics of IH-MAG resemble capillary malformations, positive GLUT-1 status is a delineating feature. Read More

    Fat-containing soft-tissue masses in children.
    Pediatr Radiol 2016 Dec 19;46(13):1760-1773. Epub 2016 Nov 19.
    Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
    The diagnosis of soft-tissue masses in children can be difficult because of the frequently nonspecific clinical and imaging characteristics of these lesions. However key findings on imaging can aid in diagnosis. The identification of macroscopic fat within a soft-tissue mass narrows the differential diagnosis considerably and suggests a high likelihood of a benign etiology in children. Read More

    Hemangioma of the oral and perioral region: Nd:YAG vs surgery.
    Ann Ital Chir 2016 Oct 14;2578. Epub 2016 Oct 14.
    Introduction: Hemangiomas are very commonly diagnosticated in childhood. The area most affected by this disease is the head and neck. In recent decades, the laser therapy has changed the treatment of hemangiomas through special techniques with advantages in bleeding risk management. Read More

    Ultrasonography as an objective tool for assessment of infantile hemangioma treatment with propranolol.
    Int J Dermatol 2017 Feb 4;56(2):190-194. Epub 2016 Nov 4.
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood. Propranolol is an effective drug in treating IH. A reliable and complementary instrument is necessary to evaluate IH response to propranolol in addition to clinical and photographic assessments. Read More

    Point-of-Care Ultrasound to Diagnose Infantile Parotid Hemangioma.
    Pediatr Emerg Care 2016 Nov;32(11):812-814
    From the Keck School of Medicine of the University of Southern California, Los Angeles, CA.
    Soft tissue masses are common in the pediatric population and may represent a broad range of conditions. Point-of-care ultrasound can be used for rapid visualization and assessment of soft tissue masses in the emergency setting. We report a case of a pediatric head and neck mass in which point-of-care ultrasound was used to identify an infantile parotid hemangioma. Read More

    [Spanish consensus on infantile haemangioma].
    An Pediatr (Barc) 2016 Nov 19;85(5):256-265. Epub 2015 Nov 19.
    Servicio de Dermatología, Hospital Sant Joan de Deu, Barcelona, Universidad de Barcelona, Esplugues de Llobregat, Barcelona, España.
    Introduction: Infantile haemangiomas are benign tumours produced by the proliferation of endothelial cells of blood vessels, with a high incidence in children under the age of one year (4-10%). It is estimated that 12% of them require treatment. This treatment must be administered according to clinical practice guidelines, expert experience, patient characteristics and parent preferences. Read More

    Infantile Hemangioma Originates From A Dysregulated But Not Fully Transformed Multipotent Stem Cell.
    Sci Rep 2016 Oct 27;6:35811. Epub 2016 Oct 27.
    Department of Medicine, New York University School of Medicine, 550 First Avenue New York, NY 10016, USA.
    Infantile hemangioma (IH) is the most common tumor of infancy. Its cellular origin and biological signals for uncontrolled growth are poorly understood, and specific pharmacological treatment is unavailable. To understand the process of hemangioma-genesis we characterized the progenitor hemangioma-derived stem cell (HemSC) and its lineage and non-lineage derivatives. Read More

    Intravenous Lobular Capillary Hemangioma in the Subclavian Vein.
    Ann Thorac Surg 2016 Nov;102(5):e427-e429
    Department of Cardiovascular Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
    We report the case of a 73-year-old man with severe edema of the right upper extremity. Computed tomography, magnetic resonance imaging, and venography revealed an intravenous tumor in the middle portion of the right subclavian vein. The tumor was completely resected, and an accompanying thrombus was also removed using the transmanubrial osteomuscular sparing approach. Read More

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