5,289 results match your criteria Infantile Hemangioma


Outcomes of surgical treatment for hemangiomas.

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina.

Objective: To quantify complications and rates of adverse events associated with surgical excision of hemangiomas in children using a national surgical database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP -pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9th revision code: 228. Read More

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http://dx.doi.org/10.1111/pde.13751DOI Listing
February 2019

[Magnetic Resonance Imaging of the Orbital Cavity: Indications and Diagnostic Possibilities].

Klin Monbl Augenheilkd 2019 Feb 18. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

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http://dx.doi.org/10.1055/a-0849-0000DOI Listing
February 2019

Current Treatment and Management of Infantile Hemangiomas.

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, University of Washington, WA, USA; Department of Oculoplastic and Reconstructive Surgery, University of Washington, WA, USA. Electronic address:

Infantile hemangiomas (IHs), otherwise known as infantile capillary hemangiomas, strawberry hemangiomas, or strawberry nevi, are non-malignant vascular tumors that commonly affect children. The natural disease course typically involves growth for up to a year followed by regression without treatment over a period of years, with no cosmetic or functional sequelae. Less commonly, however, IHs can become a threat to vision or even life depending on location and size of the lesion. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.02.005DOI Listing
February 2019

Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier.

Front Neurosci 2019 31;13:33. Epub 2019 Jan 31.

INSERM U1220 Institut de Recherche en Santé Digestive, CHU Purpan, Université Toulouse III Paul Sabatier, Toulouse, France.

Propranolol is the first-line treatment for infants suffering from infantile hemangioma. Recently, some authors raised the question of potential neurologic side effects of propranolol due to its lipophilic nature and thus its ability to passively cross the blood-brain barrier (BBB) and accumulate into the brain. Hydrophilic beta-blockers, such as atenolol and nadolol, where therefore introduced in clinical practice. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00033
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http://dx.doi.org/10.3389/fnins.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365417PMC
January 2019
1 Read

A barrier to care: Distance traveled affects adherence to treatment and follow-up plans for patients with infantile hemangioma.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Texas Children's Hospital, The Woodlands, Texas.

A chart review was performed of all patients diagnosed with infantile hemangioma in the pediatric dermatology clinic to determine whether distance traveled by the patient affected adherence to follow-up and treatment plans. An increase in distance was associated with an increase in likelihood of nonadherence to treatment or follow-up plans. Compared to patients who lived within 10 miles of a pediatric dermatologist, families who lived farther away were less likely to adhere to treatment plans. Read More

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http://dx.doi.org/10.1111/pde.13788DOI Listing
February 2019

Combination therapy of propranolol, levothyroxine, and liothyronine was effective in a case of severe consumptive hypothyroidism associated with infantile hepatic hemangioma.

Clin Pediatr Endocrinol 2019 31;28(1):9-14. Epub 2019 Jan 31.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Infantile hepatic hemangioma (IHH) can be accompanied by consumptive hypothyroidism. We report the case of a 4-mo-old boy who showed massive hepatomegaly, peripheral coldness, lethargy, and failure to thrive. An enhanced computed tomography scans demonstrated multiple hemangiomas in both lobes of the liver, and a thyroid function tests showed severe hypothyroidism: TSH 561. Read More

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http://dx.doi.org/10.1297/cpe.28.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356094PMC
January 2019
1 Read

Lingual Alveolar Soft Part Sarcoma in a 1-Year-Old Infant: Youngest Reported Case With Characteristic ASPSCR1-TFE3 Fusion.

Pediatr Dev Pathol 2019 Feb 11:1093526619830290. Epub 2019 Feb 11.

1 Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Alveolar soft part sarcoma (ASPS) is an exceptionally rare non-rhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(11.2;q25). This translocation results in the chimeric ASPSCR1-TFE3 transcription factor which drives tumorigenesis. Read More

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http://dx.doi.org/10.1177/1093526619830290DOI Listing
February 2019

Associations between short-term efficacy and clinical characteristics of infantile hemangioma treated by propranolol.

Medicine (Baltimore) 2019 Feb;98(6):e14346

Department of Vascular anomalies and Interventional Radiology, Qilu Children's Hospital of Shandong University, Jingshi Road, Jinan City, Shandong Province, China.

Propranolol is the mainstay of treatment for infantile hemangiomas (IHs) benefited from its low complication in the present study. However, it has an uncertainty treating period with cumbersome methods which may be related to clinical features. This study sought to considered possible influences of short-term efficacy to medication. Read More

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http://dx.doi.org/10.1097/MD.0000000000014346DOI Listing
February 2019
1 Read

Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas.

Mol Med Rep 2019 Jan 24. Epub 2019 Jan 24.

Department of Anatomy, Anhui Medical University, Hefei, Anhui 230601, P.R. China.

Infantile hemangiomas (IH) are the most common infantile neoplasms and are characterized by initial proliferation during infancy and subsequent spontaneous regression within the next 5‑10 years, frequently leaving fibrous fat residues. However, the specific mechanisms underlying the differentiation of hemangioma stem cells (HemSCs) into adipocytes are not clear. The purpose of the present study was to investigate the effect of insulin‑like growth factor I (IGF‑1) on HemSCs from patients with IH and to determine the signaling mechanisms involved. Read More

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http://dx.doi.org/10.3892/mmr.2019.9895DOI Listing
January 2019

Late ulceration of residual abortive infantile hemangioma: a rare complication.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Dermatology and Reference center for Genodermatoses and Rare Skin Diseases (MAGEC), Université Paris Descartes - Sorbonne Paris Cité, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, APHP, Paris, France.

Abortive and minimal growth infantile hemangiomas (IH) are present at birth and have a proliferative component of less than 25% of their total surface. Clinically, they appear most frequently as a telangiectatic patch with venules, surrounded by a halo of vasoconstriction. They may be large or small, segmental or focal. Read More

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http://dx.doi.org/10.1111/bjd.17717DOI Listing
February 2019
1 Read

[Posterior mediastinum infantile hemangioma in an 11 months infant, an unusual finding. A case report and review of the literature].

Cir Pediatr 2019 Jan 21;32(1):46-48. Epub 2019 Jan 21.

Servicio de Cirugía Pediátrica. Hospital Universitario de Canarias. La Laguna, Tenerife.

Mediastinal infantile hemangioma has not been reported so far (as far as we are aware), using accurate diagnostic methods. MRI scans are essential for a correct characterization and assessment of the extension. Moreover, Endothelial cell glucose transporter 1 (GLUT1) isoform protein represents an extremely important diagnostic tool to differentiate Infantile Hemangioma from other vascular neoplasms. Read More

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January 2019

MiR-187-3p Enhances Propranolol Sensitivity of Hemangioma Stem Cells.

Cell Struct Funct 2019 Feb 2. Epub 2019 Feb 2.

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine.

Infantile hemangioma is the most common soft tissue tumors in childhood. In clinic, propranolol is widely used for infantile hemangioma therapy. However, some of the infantile hemangioma patients display resistance to propranolol treatment. Read More

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https://www.jstage.jst.go.jp/article/csf/advpub/0/advpub_180
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http://dx.doi.org/10.1247/csf.18041DOI Listing
February 2019
3 Reads

Itraconazole induces regression of infantile hemangioma via down-regulation of the PDGF-D/PI3K/Akt/mTOR pathway.

J Invest Dermatol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common anti-fungal agent, can clinically improve or cure IH; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits the proliferation and promotes apoptosis of the endothelial cells of mouse hemangioma (EOMA) cell line and infantile primary hemangioma endothelial cell (HemEC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193003
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http://dx.doi.org/10.1016/j.jid.2018.12.028DOI Listing
January 2019
6 Reads

"Intramedullary capillary hemangioma presenting with hydrocephalus and spastic paraparesis in a two-month-old infant".

World Neurosurg 2019 Jan 24. Epub 2019 Jan 24.

Director and Head, Department of Radiology, Fortis Memorial Research Institute, Gurugram, Haryana-122003. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.01.067DOI Listing
January 2019
1 Read

Efficacy of infantile hepatic hemangioma with propranolol treatment: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14078

Division of Gastroenterology and Hepatology, Department of Pediatrics, MacKay Children's Hospital.

Rationale: Hepatic hemangioma is rarely discovered during the infantile period. Although most of the cases are asymptomatic, some of them may suffer life-threatening situations. In this regard, early detection is mandatory for preventing the ominous consequences that might be culminated from the disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000014078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358341PMC
January 2019
1 Read

Infantile hemangiomas: our current understanding and treatment options.

Dermatol Online J 2018 Sep 15;24(9). Epub 2018 Sep 15.

State University of New York Downstate, Department of Dermatology, Brooklyn, New York Veterans Health Administration, Department of Dermatology, Brooklyn, New York.

Infantile hemangioma (IH) is the most common vascular tumor of infancy, affecting up to 10% of all infants. Our understanding of IH and its management has greatly evolved. The etiology of IH is unclear but hypoxia is thought to play a key role. Read More

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September 2018

Giant Hepatic Hemangioma and Placental Chorangiosis: A Unique Case of Stillbirth?

Fetal Pediatr Pathol 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Pathology, DISC , University of Genoa , Genoa , Italy.

Introduction: Hepatic hemangiomas (HH) are benign vascular tumors, and when large, may contribute to fetal morbidity/mortality. Chorangiosis is placental villus capillary hypervascularity, probably linked with fetal hypoxia.

Case Report: We present a macrosomic stillbirth at 39 + 3 weeks of gestation with congestive heart failure (CHF) and myocardial infarction. Read More

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http://dx.doi.org/10.1080/15513815.2018.1564159DOI Listing
January 2019
1 Read
0.398 Impact Factor

Verrucous Hemangioma.

Eplasty 2019 7;19:ic1. Epub 2019 Jan 7.

Department of Plastic Surgery, Morsani College of Medicine, Tampa, Fla.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328935PMC
January 2019

A primary cutaneous vascular neoplasm with histologic features of anastomosing hemangioma.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Departments of Pathology/Microbiology, Pediatrics and Orthopaedic Surgery, Nebraska Medical Center, Omaha, Nebraska.

Anastomosing hemangioma (AH) is a relatively novel variant of benign vascular tumors originally described in the genitourinary tract. Although AH was subsequently documented in various anatomic locations, a primary AH of the skin has not been reported in the literature. The current case report documents a vascular lesion with histologic features reminiscent of an AH. Read More

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http://doi.wiley.com/10.1111/cup.13426
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http://dx.doi.org/10.1111/cup.13426DOI Listing
January 2019
2 Reads

Congenital Large Cutaneous Hemangioma with Arteriovenous and Arterioarterial Malformations: A Novel Association.

Fetal Pediatr Pathol 2019 Jan 19:1-6. Epub 2019 Jan 19.

c Department of Gyneco-Obstetrics, Hospital Habib Bougatfa, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.

Background: Congenital cutaneous hemangioma is a benign vascular lesion that is a leading cause of severe hemodynamic compromise in a fetus when it is of significant size and especially in association with arteriovenous malformation.

Case Report: A large cutaneous hemangioma involving the right arm of a 32-week-old male fetus was complicated by fetal hypotrophy, hydrops fetalis and neonatal death. Axillary arteriovenous fistulas and bilateral arterial carotid-subclavian anastomosis were demonstrated at autopsy. Read More

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http://dx.doi.org/10.1080/15513815.2018.1547337DOI Listing
January 2019
2 Reads

Safety assessment during initiation and maintenance of propranolol therapy for infantile hemangiomas.

Adv Clin Exp Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Pediatric Surgery and Urology, Wroclaw Medical University, Poland.

Background: Propranolol is an effective method of treatment for infantile hemangiomas (IH). A recent concern is a shift of the therapy into outpatient settings.

Objectives: The aim of the study was to evaluate the safety of initiating and maintaining propranolol therapy for IH. Read More

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http://dx.doi.org/10.17219/acem/94136DOI Listing
January 2019
2 Reads

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells.

Exp Ther Med 2019 Jan 2;17(1):307-315. Epub 2018 Nov 2.

Department of Dermatology, University of Medicine and Pharmacy 'Iuliu Hațieganu', 400012 Cluj-Napoca, Romania.

Infantile hemangioma is one of the most common benign tumors affecting children, with ~10-15% requiring medical treatment. These tumors consist of endothelial cells and stromal components, including fibroblasts, pericytes and mast cells. Effects of propranolol treatment in combination with bevacizumab or vincristine on cell growth were compared in the current study using human umbilical vein endothelial cells (HUVECs) and BJ human normal fibroblasts (BJs) to determine potential synergic effects . Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6925
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http://dx.doi.org/10.3892/etm.2018.6925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307438PMC
January 2019
6 Reads

Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills.

J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.14762DOI Listing
January 2019

Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas.

Front Oncol 2018 18;8:605. Epub 2018 Dec 18.

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. Oral propranolol has achieved great success in treating IHs since 2008. To minimize the systemic side events caused by oral administration of propranolol, topical timolol started to be applied in the treatment of IHs, especially for superficial lesions. Read More

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http://dx.doi.org/10.3389/fonc.2018.00605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305365PMC
December 2018
3 Reads

No Increased Risks Associated with Propranolol Treatment for Infantile Hemangioma in Preterm Infants were Identified at 3 Years of Age.

Am J Clin Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

Background: Concerns have been raised that propranolol treatment of infantile hemangioma (IH) may be associated with increased risks of adverse effects and growth impairment in preterm infants due to their immature development.

Objective: This study aimed to find out whether treatment of IH with propranolol in preterm infants is associated with higher incidences of long-term adverse effects and growth impairment in comparison with term infants.

Methods: The clinical data of 55 preterm infants and 180 term infants with IH treated with oral propranolol for 6 months were retrospectively collected and analyzed. Read More

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http://dx.doi.org/10.1007/s40257-018-00419-1DOI Listing
January 2019
2 Reads
2.519 Impact Factor

Effectiveness of topical propranolol 4% gel in the treatment of pyogenic granuloma in children.

J Dermatol 2018 Dec 28. Epub 2018 Dec 28.

Pediatric Dermatology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Pyogenic granuloma is a benign acquired vascular tumor that affects the skin and mucous membranes, occurring more often in children and young adults. Treatment is often required due to the associated risk of ulceration and bleeding. There are several publications reporting the use of beta-blockers for the treatment of pyogenic granuloma. Read More

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http://dx.doi.org/10.1111/1346-8138.14740DOI Listing
December 2018
3 Reads

Small Bowel Pyogenic Granuloma With Cytomegalovirus Infection in a Patient With Crohn's Disease (Report of a Case and Review of the Literature).

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

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http://dx.doi.org/10.21873/invivo.11468DOI Listing
October 2018
8 Reads
1.148 Impact Factor

PHACE syndrome: Infantile hemangiomas associated with multiple congenital anomalies: Clues to the cause.

Authors:
Dawn H Siegel

Am J Med Genet C Semin Med Genet 2018 Dec;178(4):407-413

Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI.

Infantile hemangiomas (IH) are the most common vascular tumor of infancy with an estimated 80,000 annual diagnoses in the United States. The genetic mechanisms underlying IH and the related multi-organ birth defect syndromes, PHACE (an acronym for Posterior fossa brain malformations, segmental facial Hemangiomas, Arterial anomalies, Cardiac defects, Eye anomalies, and sternal clefting or supraumbilical raphe) and LUMBAR (an acronym for Lower body hemangiomas, Urogenital anomalies, Myelopathy, Bone deformities, Anorectal malformations/Arterial anomalies, Renal anomalies) remain unsolved. With advances in next generation sequencing (NGS), genomic alterations have been identified in a wide range of vascular anomaly syndromes. Read More

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http://dx.doi.org/10.1002/ajmg.c.31659DOI Listing
December 2018
2 Reads

Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement.

MAbs 2019 Jan 12;11(1):26-44. Epub 2018 Dec 12.

a UltraHuman Limited, Codebase , Edinburgh , UK.

Monoclonal anti-programmed cell death 1 (PD1) antibodies are successful cancer therapeutics, but it is not well understood why individual antibodies should have idiosyncratic side-effects. As the humanized antibody SHR-1210 causes capillary hemangioma in patients, a unique toxicity amongst anti-PD1 antibodies, we performed human receptor proteome screening to identify nonspecific interactions that might drive angiogenesis. This screen identified that SHR-1210 mediated aberrant, but highly selective, low affinity binding to human receptors such as vascular endothelial growth factor receptor 2 (VEGFR2), frizzled class receptor 5 and UL16 binding protein 2 (ULBP2). Read More

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http://dx.doi.org/10.1080/19420862.2018.1550321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343799PMC
January 2019
17 Reads

Effect of dosing regimen and microneedle pretreatment on in vitro skin retention of topically applied beta-blockers.

Biomed Microdevices 2018 12 6;20(4):100. Epub 2018 Dec 6.

Department of Pharmaceutical Science and Experimental Therapeutics, University of Iowa College of Pharmacy, 115 South Grand Avenue, Iowa City, IA, 52242, USA.

Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths. Read More

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http://dx.doi.org/10.1007/s10544-018-0348-7DOI Listing
December 2018
2 Reads

Cystic Anastomosing Hemangioma of the Ovary: A Case Report With Immunohistochemical and Ultrastructural Analysis.

Int J Surg Pathol 2018 Dec 6:1066896918817148. Epub 2018 Dec 6.

1 Istanbul University, Istanbul, Turkey.

In this article, we present a case of anastomosing hemangioma that shows cystic change. The tumor was a unilocular cystic lesion consisting of 2 distinct layers. The inner layer was composed of a proliferation of capillary-sized blood vessels resembling red pulp of the spleen. Read More

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http://dx.doi.org/10.1177/1066896918817148DOI Listing
December 2018
1 Read

Medical Management of Vascular Anomalies.

Curr Treat Options Pediatr 2018 Jun 27;4(2):221-236. Epub 2018 Apr 27.

Division of Pediatric Otolaryngology, Department of Surgery, Seattle Children's Hospital and Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington, United States.

Purpose Of Review: This chapter will summarize the most recent literature regarding the current state of medical treatment for vascular anomalies.

Recent Findings: Research into the biology of these anomalies has strengthened our understanding of each anomaly and has helped to pave the way for more tailored treatment options involving molecular and/or genetic targets.

Summary: While there is still a role for surgical intervention, medical therapies that target the etiology of vascular anomalies may represent an alternative or adjunctive approach in the management of these lesions. Read More

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http://link.springer.com/10.1007/s40746-018-0130-3
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http://dx.doi.org/10.1007/s40746-018-0130-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261360PMC
June 2018
21 Reads

Infantile Hepatic Hemangioma.

J Pak Med Assoc 2018 Dec;68(12):1846-1847

Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Infantile hepatic hemangioma (IHH) historically called "hemangiomaendothelioma" refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Read More

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December 2018
10 Reads

A Large Infantile Capillary Hemangioma of the Eyelid with 5 Years Follow-up.

J Coll Physicians Surg Pak 2018 Dec;28(12):970-971

Department of Pathology, Khyber Medical College, Peshawar, Pakistan.

A five-day baby girl presented with a large mass involving the right upper and lower eyelid obstructing the visual axis completely. She was treated with intralesional triamcinolone acetonide injection under general anesthesia but no change in size of the tumor was observed. Oral beta blocker, propranolol, 1 mg/kg body weight, was given at three months. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.12.970DOI Listing
December 2018
1 Read

Efficacy and safety of oral atenolol for the treatment of infantile haemangioma: A systematic review.

Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.

Recently, several studies have reported their experience in using oral atenolol in patients with infantile haemangioma (IH), especially as an alternative to propranolol, but the efficacy and safety of oral atenolol has not been evaluated. We searched PubMed (Medline), Central, Embase, Web of Science and EBSCOhost (until May 2018) for the eligible studies reporting more than 10 IH patients who were treated with oral atenolol with detailed original data, including outcomes, regimens and adverse events (AEs). The data was standardised and analysed by using R software with meta-package. Read More

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http://dx.doi.org/10.1111/ajd.12966DOI Listing
December 2018
4 Reads

Thin polymeric films for the topical delivery of propranolol.

Colloids Surf B Biointerfaces 2019 Feb 12;174:582-586. Epub 2018 Nov 12.

Department of Food and Drug, Parco Area delle Scienze 27/A, Università di Parma, 43124, Parma, Italy. Electronic address:

Background/aims: Infantile hemangioma (IH), the most common benign tumor of childhood, is currently treated with propranolol. The aim of this work was to study in vitro propranolol permeation and skin retention from an original polymeric film, composed of polyvinyl alcohol and an acrylic polymer.

Methods: Propranolol polymeric films were applied in occlusive and non-occlusive conditions, on either full thickness skin or isolated epidermis. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.11.022DOI Listing
February 2019
4 Reads

Clinical features of canine pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.

J Vet Intern Med 2019 Jan 29;33(1):114-123. Epub 2018 Nov 29.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Background: Histologic features of pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description.

Objectives: To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH.

Animals: Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small-sized to medium-sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both. Read More

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http://doi.wiley.com/10.1111/jvim.15351
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http://dx.doi.org/10.1111/jvim.15351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335444PMC
January 2019
1 Read

Repurposing propranolol as an antitumor agent in von Hippel-Lindau disease.

J Neurosurg 2018 Oct 1:1-9. Epub 2018 Oct 1.

1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

OBJECTIVEVon Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs account for significant morbidity and mortality, ultimately necessitating numerous neurological and renal surgeries. Propranolol is an FDA-approved pan-beta adrenergic antagonist with antitumor effects against infantile hemangiomas (IHs) and possibly VHL HBs. Read More

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http://dx.doi.org/10.3171/2018.5.JNS172879DOI Listing
October 2018
1 Read
3.737 Impact Factor

Episcleral racemose hemangioma.

J AAPOS 2018 Nov 20. Epub 2018 Nov 20.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Racemose hemangioma is a rare, benign vascular malformation. In the episclera, it appears as dilated, tortuous blood vessels that pass from the fornix over the globe surface to the limbal area, without capillary architecture, and then loop backward into the fornix. Fluorescein angiogram reveals the vascular malformation with rapid flow and confirms the episcleral vessels to be large in caliber and with a curvilinear, twisted configuration. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.10.007DOI Listing
November 2018
13 Reads

Oral propranolol therapy in 23 infants with infantile hemangioma.

Arch Plast Surg 2018 Nov 15;45(6):517-524. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.

Background: Infantile hemangioma (IH) is a common vascular tumor in pediatric patients, and is commonly treated with propranolol. We describe our experiences with dosage, response to treatment, and side effects in 23 IH patients treated with propranolol.

Methods: For this nonrandomized comparative cohort study, the authors enrolled 23 patients treated with propranolol. Read More

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http://dx.doi.org/10.5999/aps.2018.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258977PMC
November 2018
17 Reads

Aural Polyp is not Always Due to Chronic Otitis Media (COM): Preoperative Computed Tomographic Scan is Good Pointer for Sinister Lesions.

Indian J Otolaryngol Head Neck Surg 2018 Dec 30;70(4):505-509. Epub 2018 Aug 30.

Department of Otorhinolaryngology, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana India.

Twenty five patients of aural polyp who underwent canal wall down mastoidectomy were analysed retrospectively. Histopathological examination revealed cholesteatoma in 22 (88%) patients. However, histopathological diagnosis in 3 of these patients was unusual and rare benign tumors of the middle ear cleft-meningioma, neurilemmoma and capillary hemangioma. Read More

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http://dx.doi.org/10.1007/s12070-018-1482-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224824PMC
December 2018
9 Reads

Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro.

Pharmacology 2019 16;103(1-2):61-67. Epub 2018 Nov 16.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing,

Background/aims: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs).

Methods: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Read More

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https://www.karger.com/Article/FullText/494762
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http://dx.doi.org/10.1159/000494762DOI Listing
November 2018
10 Reads
1.581 Impact Factor

Vascular malformation in a bicuspid aortic valve.

Cardiovasc Pathol 2019 Jan - Feb;38:39-41. Epub 2018 Oct 24.

Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015-, Paris, France.

We report here a case of capillary vascular malformation developed in a bicuspid aortic valve incidentally detected during valve replacement in a 67-year-old male patient. The International Society for the Study of Vascular Anomalies (ISSVA) classification was used to classify this vascular lesion instead of using the term hemangioma. The differential diagnosis and the literature are reviewed. Read More

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https://www.cardiovascularpathology.com/article/S1054-8807(1
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https://linkinghub.elsevier.com/retrieve/pii/S10548807183029
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http://dx.doi.org/10.1016/j.carpath.2018.10.006DOI Listing
October 2018
9 Reads

Atypical Presentation of Pyogenic Granuloma of the Right Index Finger: A Rare Case Report.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):577-580

1 Department of Orthopaedics, Miri General Hospital, Miri, Malaysia.

Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular lesion of the skin or mucous membrane with rapid growth or repetitive trauma. Rarely seen in adult, its management varies and surgical intervention is usually common. We report a case of pyogenic granuloma of the right index finger in a 46-year-old gentleman who presented with painless swelling of the right index finger after a trivial injury. Read More

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http://dx.doi.org/10.1142/S2424835518720335DOI Listing
December 2018
1 Read

Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma.

JAMA Ophthalmol 2019 Jan;137(1):91-95

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Importance: Choroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.

Objective: To determine whether the mutation found in most capillary malformations, GNAQ R183Q (c. Read More

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https://jamanetwork.com/journals/jamaophthalmology/fullartic
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http://dx.doi.org/10.1001/jamaophthalmol.2018.5141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382586PMC
January 2019
7 Reads

Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.

Eur J Pediatr 2019 Jan 12;178(1):1-6. Epub 2018 Nov 12.

Department of Pediatric Surgery, Vascular Anomalies Center, Autonoma University of Madrid, Madrid, Spain.

Propranolol has changed the management of infantile hemangiomas (IHs). We summarize the evolution of surgical treatment for IH at La Paz Children's Hospital (Madrid) in the era of propranolol, with a focus on hepatic IHs.Retrospectively, we compared surgical treatment of IHs in children referred during the periods 2004-2009 and 2009-2014. Read More

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http://dx.doi.org/10.1007/s00431-018-3290-zDOI Listing
January 2019
5 Reads

[Rare presentations of infantile hemangiomas: 4 cases].

Ann Dermatol Venereol 2018 Dec 9;145(12):749-755. Epub 2018 Nov 9.

Service de dermatologie, centre hospitalier régional et universitaire de Nancy, 54500 Vandœuvre-lès-Nancy, France.

Background: Infantile hemangioma (IH) is a common benign vascular tumor in children. In most cases, diagnosis is based entirely on clinical examination. When the diagnosis is uncertain, the first-line complementary examination is Doppler ultrasound. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183052
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http://dx.doi.org/10.1016/j.annder.2018.07.026DOI Listing
December 2018
7 Reads