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    [Clinical and imaging features of pulmonary veno-occlusive disease and pulmonary capillary hemangioma].
    Zhonghua Jie He He Hu Xi Za Zhi 2018 Jan;41(1):41-46
    Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medice, Shanghai 200433, China.
    Objective: To improve the diagnosis and treatment of the pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangioma (PCH). Methods: The clinical features, radiological findings, laboratory testing and treatment in 8 cases of PVOD/PCH which was diagnosed from 2013 to 2017 were described. Results: PVOD/PCH was rare. Read More

    Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions.
    Am J Med Genet A 2018 Jan 17. Epub 2018 Jan 17.
    Department of Pediatrics, University of California San Diego, San Diego, California.
    The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013. A total of 51/969 (5. Read More

    [Mammary hemangioma in an infant with apparent mastitis. Case report].
    Arch Argent Pediatr 2018 Feb;116(1):e98-e101
    Pediatría, Servicio de Oncohematología Infantil, Hospital General Universitario Gregorio Marañón, Madrid, España.
    Mammary pathology is infrequent during childhood. It is rare the probability of finding a breast mass in an infant. The most frequent possible diagnoses at this age are breast abscess, mastitis, breast engorgement due to maternal hormonal stimulation and hemangioma. Read More

    Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas.
    Pediatr Dermatol 2018 Jan 9. Epub 2018 Jan 9.
    Departments of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.
    Topical timolol maleate has recently gained popularity as a treatment for superficial infantile hemangiomas, but calculating a safe dose of timolol can be time consuming, which may limit the medication's use in fast-paced clinical environments. This report offers a simplified calculation of the maximum daily safe dosage as 1 drop of medication per kilogram of body weight. Read More

    Pediatric Testicular Hemangioma in a 10-Year-Old: a Rare Entity That May Mimic Malignancy with Appraisal of the Literature.
    Urology 2018 Jan 3. Epub 2018 Jan 3.
    University of Pittsburgh School of Medicine, UPMC Department of Pathology; Children's Hospital of Pittsburgh of UPMC. Electronic address:
    Capillary hemangioma is a rare benign lesion in the testicle, particularly in pediatrics. It can mimic malignancy, leading to radical orchiectomy. We present a case of a testicular hemangioma in a child, and review the literature on testicular hemangiomas in this age group. Read More

    Effect of oral propranolol on periocular Capillary Hemangiomas of Infancy.
    Pediatr Neonatol 2017 Dec 6. Epub 2017 Dec 6.
    Dept of Pediatric Ophthalmology & Strabismus, Sankara Nethralaya, Medical Research Foundation, Chennai, India.
    Background: To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI).

    Methods: Medical records of 21 infants diagnosed with periocular capillary hemangioma during a period of 5 years from 2009 to 2014 were retrospectively reviewed. The data collected included demographic details, clinical features and details of imaging studies and response to the therapy. Read More

    Management trends of infantile hemangioma: A national perspective.
    Int J Pediatr Otorhinolaryngol 2018 Jan 2;104:84-87. Epub 2017 Nov 2.
    Medical College of Wisconsin, Department of Otolaryngology & Communication Sciences, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Children's Hospital of Wisconsin, Division of Pediatric Otolaryngology, 8915 W. Connell Court, Milwaukee, WI 53226, USA. Electronic address:
    Introduction: The primary management of infantile hemangioma (IH) has changed since 2008, with the initiation of propranolol. The change that propranolol has affected on resource utilization is unknown.

    Materials And Methods: The Kids' Inpatient Database (KID) in 2003, 2006, 2009, and 2012 was queried for ICD-9 codes for IH in children under age three. Read More

    Restricted Range of Motion and a Cold Upper Extremity in a Two-Year-Old Boy: Kaposiform Hemangioendothelioma of the Bone and the Brachial Plexus: A Case Report.
    JBJS Case Connect 2017 Oct-Dec;7(4):e79
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California.
    Case: We report a case of kaposiform hemangioendothelioma (KHE) of the scapula in a 2-year-old boy with motor and sensory abnormalities of the left upper extremity, suggesting brachial plexus involvement. The locally invasive nature prevented resection; sirolimus therapy resulted in improvement of the motor and sensory impairment, as well as decreased tumor size on imaging.

    Conclusion: Osseous infiltration of KHE is known to occur, but its primary presentation in bone without skin involvement is rare and diagnostically challenging. Read More

    Combined approach to management of periocular arteriovenous malformation by interventional radiology and surgical excision.
    Indian J Ophthalmol 2018 Jan;66(1):151-154
    Department of Interventional Radiology, Apollo Specialty Hospitals, Chennai, Tamil Nadu, India.
    Periorbital arteriovenous malformations (AVMs) are congenital lesions that may cause significant morbidity such as amblyopia, cosmetic disfigurement, or chronic pain. Due to the rarity of these lesions, they are frequently misdiagnosed and treated inappropriately. We managed a 6-year-old girl with preseptal AVM by endovascular embolization followed by complete surgical excision after 2 days. Read More

    Endogenous peptides profiles of human infantile hemangioma tissue and their clinical significance for treatment.
    J Cell Biochem 2017 Dec 21. Epub 2017 Dec 21.
    Department of Plastic&Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China.
    Endogenous peptides recently attract increasing attention for their participation in various biological processes. Their roles in the pathogenesis of human infantile hemangioma remains poorly understood. In this study, we used liquid chromatography-tandem mass spectrometry to construct a comparative peptidomic profiling between human infantile hemangioma tissue and matched normal skin. Read More

    Eczematous dermatitis in an infantile hemangioma with minimal or arrested growth.
    Pediatr Dermatol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Dermatology, School of Medicine, University of Virginia, Charlottesville, VA, USA.
    Infantile hemangiomas (IHs) with minimal or arrested growth differ from standard IHs in that they have a reduced or absent growth phase. An association between IHs with minimal or arrested growth and superimposed eczematous dermatitis has not been described in the literature. We present a case detailing this association in which an IH with minimal or arrested growth responded well to treatment with propranolol and the superimposed eczema cleared completely with topical hydrocortisone. Read More

    Unusual Case of Acquired Capillary Hemangioma of the Eyelid in an Adult.
    Ann Maxillofac Surg 2017 Jul-Dec;7(2):308-311
    Department of Plastic Surgery, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India.
    Acquired capillary hemangioma of the eyelid is very uncommon in adults. To our knowledge, only eight such cases have been reported in the literature till date. We report the case of a 25-year-old female with acquired capillary hemangioma of the left lower eyelid treated by cutting diathermy followed by reconstruction of the cutaneous and cartilaginous defect. Read More

    Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas.
    Clin Ophthalmol 2017 8;11:2177-2181. Epub 2017 Dec 8.
    Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
    Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.

    Patients And Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Read More

    [What's new in pediatric dermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS29-IVS39
    Centre de référence des maladies rares de la peau et des muqueuses d'origine génétique, service de dermatologie, hôpital Archet 2, CHU de Nice, France. Electronic address:
    The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example. There were also clinical articles on various affections such as the sign of the scalp hair collar sign, childhood prurigo, ichthyosis, atopic dermatitis, warts or Zika virus infection. Read More

    A prospective study of topical carteolol therapy in Chinese infants with superficial infantile hemangioma.
    Pediatr Dermatol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of China Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
    Background/objective: To report our observations from a trial of the short-term effectiveness and safety of topical carteolol hydrochloride drops to treat infantile hemangiomas (IHs).

    Methods: From October 2012 to September 2015, the study recruited 349 children with superficial IHs. Participants were randomized to two groups: treatment (n = 224 who received 2% carteolol hydrochloride drops administered to the lesion surface twice daily) and observation (n = 125 who did not receive treatment). Read More

    Holmes heart and tetralogy of Fallot in association with PHACE.
    Pediatr Dermatol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
    PHACE is an association between large infantile hemangiomas and brain, arterial, cardiac, and/or ocular abnormalities. Aortic or subclavian aberrations are the most common cardiovascular anomalies in PHACE, whereas complex congenital heart disease is rare. We report a case of Holmes heart and three cases of tetralogy of Fallot in PHACE association. Read More

    [Research progresses in the pathogenesis, diagnosis and treatment of infantile hemangioma with PHACE syndrome].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Dec;19(12):1291-1296
    Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
    Infant hemangioma, the most common benign tumor in children, is characterized by rapid proliferation, followed by slower spontaneous involution. However, some patients with facial segmental hemangioma are associated with PHACE syndrome. PHACE syndrome is characterized by vascular nerve and vascular cutaneous lesions of multiple systemic systems, often resulting in structural and functional impairments. Read More

    Reversible profound sensorineural hearing loss due to propranolol sensitive hemangioma in an infant with PHACE syndrome.
    Int J Pediatr Otorhinolaryngol 2017 Dec 5;103:55-57. Epub 2017 Oct 5.
    University of Utah, Division of Otolaryngology, United States.
    PHACE syndrome is the association of large or segmental infantile hemangiomas of the face or scalp with abnormalities within the posterior fossa, arteries, cardiovascular system, and eyes. We present a case of reversible profound sensorineural hearing loss due to a cerebellopontine angle infantile hemangioma that was successfully treated with propranolol. Read More

    Congenital Vascular Tumors.
    Otolaryngol Clin North Am 2018 Feb;51(1):89-97
    Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue Boston, MA, 02115, USA. Electronic address:
    Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Read More

    Infantile Hemangiomas in the Head and Neck Region.
    Otolaryngol Clin North Am 2018 Feb;51(1):77-87
    Division of Hematology, Vascular Anomalies Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Oncology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Division of Hematology, Hemangioma and Vascular Malformation Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Infantile hemangiomas (IHs) are benign vascular tumors of infancy most common in the region of the head and neck. Infantile hemangiomas are common; but they are extremely heterogeneous and cause a range of complications depending on their morphology, size, or location. Medical interventions for high-risk patients include topical and systemic therapies, including oral propranolol, which has revolutionized the management of IHs over the past recent years. Read More

    Management of Infantile Hemangiomas of the Airway.
    Otolaryngol Clin North Am 2018 Feb;51(1):133-146
    Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, 600 Gresham Drive, Norfolk, VA 23507, USA. Electronic address:
    Infantile hemangiomas (IHs) of the airway are far less common than their cutaneous counterparts, and their symptoms mimic those of viral croup. As a result, by the time these lesions are diagnosed, they are often advanced and causing airway compromise. Fortunately, the evolution of propranolol as an effective and safe pharmacotherapy has simplified management of IH and reduced the likelihood of complications previously seen with steroid therapy and surgery. Read More

    The Surgical Management of Infantile Hemangiomas.
    Otolaryngol Clin North Am 2018 Feb;51(1):125-131
    Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, Vascular Birthmark Institute of New York, Department of Otolaryngology-Head and Neck Surgery, 210 East 64th Street, 7th Floor, New York, NY 10065, USA. Electronic address:
    The surgical management of facial infantile hemangiomas presents a unique challenge. The aim of the surgeon should be to remove the hemangioma and to restore normal facial features. Each of the facial zones has its own special features and challenges. Read More

    The Role of Surgery in the Management of Infantile Hemangiomas: What is the Best Timing?
    Otolaryngol Clin North Am 2018 Feb;51(1):119-123
    The Hemangioma and Malformation Treatment Center, Charleston, SC, USA. Electronic address:
    Surgery for the management of infantile hemangiomas has become commonplace. Surgical technique articles are plentiful; however, little has been written about the timing of surgery. Knowledge of the biology of the tumors, data from developmental psychology, and the utility of facial reconstruction provide guidelines for timing of surgical intervention. Read More

    Nasal Septal Cavernous Hemangioma.
    J Craniofac Surg 2017 Dec 6. Epub 2017 Dec 6.
    Otorhinolaryngology Clinic, Health Sciences University, Umraniye Education and Training Hospital, Istanbul, Turkey.
    Hemangiomas are benign tumors originating from the skin, mucosa, muscle, gland, and vascular tissue in the bone. Although it is common in the head and neck region, it is rarely seen in the nasal cavity and paranasal sinuses. Histologically capillary, cavernous, and mixed types are present, the most common is cavernous-type hemangioma. Read More

    Infantile hemangioma: pathogenesis and mechanisms of action of propranolol.
    J Dtsch Dermatol Ges 2017 Dec 28;15(12):1185-1190. Epub 2017 Nov 28.
    Department of Dermatology, University of São Paulo Medical School, Brazil.
    Infantile hemangioma (IH) is the most common benign tumor of childhood, with a prevalence of 4 % to 10 %. It is characterized by a proliferative rapid growth phase, which starts after a few weeks of life, followed by a slow regression phase. In IH cases that are potentially disfiguring or life-threatening (10 % to 15 % of all cases), systemic therapy should be promptly initiated. Read More

    Significant inhibition of infantile hemangioma growth by sustained delivery of urea from liposomes-in-microspheres.
    Oncol Rep 2018 Jan 20;39(1):109-118. Epub 2017 Nov 20.
    Department of Hemangioma and Vascular Malformation, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.
    Infantile hemangioma (IH) is a benign pediatric tumor, and rapid growth of IH can result in serious morbidity and even mortality. Only one drug Hemangeol™ (propranolol hydrochloride oral solution) has been approved for the treatment of IH, whereas patients suffer from its adverse effects and high frequency of administration. We have used urea, an organic compound and a normal body metabolite, in the treatment of IH for 20 years, and demonstrated that urea is an effective and well-tolerated treatment for IH. Read More

    Solitary pulmonary capillary hemangioma presents as ground glass opacity on computed tomography indicating adenocarcinoma in situ/atypical adenomatous hyperplasia: A case report.
    Biomed Rep 2017 Dec 9;7(6):515-519. Epub 2017 Oct 9.
    Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
    Solitary pulmonary capillary hemangioma (SPCH) is a rare type of benign lung tumor, which must be distinguished from early lung cancer and precancerous lesions of the lung that manifest in a similar way upon imaging. The current study describes a case of SPCH and a review of the literature is performed. The patient was a 40-year-old Chinese woman who was referred to the Liaoning Cancer Hospital and Institute (Shenyang, China) in October, 2015 with a cough without obvious inducement. Read More

    Atypical Presentation of Infantile Hepatic Hemangioma: A Case Study.
    Neonatal Netw 2017 Nov;36(6):374-379
    Infantile hepatic hemangioma (IHH) is the most common benign hepatic tumor of infancy. It is characterized by rapid proliferation in the first year of life, followed by slow involution during childhood. Presentation can range from asymptomatic to severe, high-output congestive heart failure (CHF). Read More

    Clinical and genetic findings in children with central nervous system arteriovenous fistulas.
    Ann Neurol 2017 Dec 12;82(6):972-980. Epub 2017 Dec 12.
    Department of genetics, Hopital Pitié-Salpêtrière, Paris, France.
    Objective: To assess the spectrum of genetic anomalies in a cohort of children presenting at least one cerebral or spinal pial arteriovenous fistula (AVF), and to describe their clinical characteristics.

    Methods: From 1988 to 2016, all consecutive patients with at least one cerebral or spinal pial AVF were screened for genetic disease. All patients aged <18 years were included. Read More

    Infantile hemangiomas: a 7-year experience of a single-center.
    Clujul Med 2017 20;90(4):396-400. Epub 2017 Oct 20.
    Department of Dermatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Objectives: The aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic.

    Methods: This is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic.

    Results: We had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Read More

    Cardiac arrest in a toddler treated with propranolol for infantile Hemangioma: a case report.
    Ital J Pediatr 2017 Nov 17;43(1):103. Epub 2017 Nov 17.
    Department of Women's and Children's Health, Pediatric Neurology and Neurophysiology, University Hospital of Padua, Padua, Italy.
    Background: Propranolol has become the first-line treatment for complicated Infantile Hemangioma (IH), showing so far a good risk-benefit profile.

    Case Presentation: We report the case of a toddler, on propranolol, who suffered cardiac arrest during an acute viral infection. She had a neurally-mediated syncope that progressed to asystole, probably because of concurrent factors as dehydration, beta-blocking and probably individual susceptibility to vaso-vagal phenomena. Read More

    [Infantile hemangioma of the eyelid].
    Ophthalmologe 2017 Dec;114(12):1171-1180
    Zentrum für Augenheilkunde, Abteilung für rekonstruktive Lid, Orbita und Tränenwegschirurgie, Brüderkrankenhaus Trier, Nordallee 1, 54292, Trier, Deutschland.
    Hemangiomas are one of the most common vascular tumors in infancy. In most cases no therapy is necessary and spontaneous regression is observed; however, if they arise in the periocular region, immediate action is required as rapid growth frequently leads to obstruction of the visual field with the risk of developing amblyopia and orbital suppression up to permanent disfigurement and stigmatization of those affected. Novel pharmaceutical treatment options led to a significant paradigm shift in the treatment of pediatric hemangiomas. Read More

    Von Hippel-Lindau Disease With Multi-Organ Involvement: A Case Report and 8-Year Clinical Course With Follow-Up.
    Am J Case Rep 2017 Nov 17;18:1220-1224. Epub 2017 Nov 17.
    Department of Radiation Oncology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
    BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. Read More

    Quality of life in children with infantile hemangioma: a case control study.
    Health Qual Life Outcomes 2017 Nov 16;15(1):221. Epub 2017 Nov 16.
    Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, #37 Guo-Xue-Xiang, Chengdu, Sichuan Province, 610041, China.
    Background: Infantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Thus, we conducted this study to evaluate the q QOL in patients with IH and find the predictors of poor QOL. Read More

    Infantile hemangiomas with conjunctival involvement: An underreported occurrence.
    Pediatr Dermatol 2017 Nov;34(6):681-685
    Department of Dermatology and Pediatrics, University of California, San Francisco, San Francisco, California.
    Background/objectives: Infantile hemangiomas (IHs) involving the conjunctiva are only anecdotally reported in the literature and little is known about their clinical course. In a retrospective case series we aimed to better delineate the clinical presentation, complications, and response to treatment of this uncommon subtype of IH. A classification of conjunctival IH is proposed. Read More

    Concurrent Sturge-Weber syndrome, facial infantile hemangioma, and cutis marmorata telangiectatica congenita.
    Cutis 2017 Oct;100(4):252-254
    Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA.
    We present a unique case of 3 vascular malformations-Sturge-Weber syndrome (SWS), facial infantile hemangioma (IH), and cutis marmorata telangiectatica congenita (CMTC)-with dermatologic manifestations presenting in the same patient. This case highlights the possibility of occurrence of multiple vascular malformations in the same patient; the potential role of epigenetic factors; and the importance of a multidisciplinary approach to diagnose, treat, and manage this complicated interplay of vascular abnormalities to achieve the best outcome. Read More

    Congenital capillary hemangioma arising from palpebral conjunctiva of a neonate.
    Indian J Ophthalmol 2017 Nov;65(11):1221-1223
    Department of Paediatric Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India.
    Capillary hemangioma is the most common benign vascular eyelid tumor in childhood. The periocular lesion appears within the first few weeks after birth and usually has superficial or deep components. Primary conjunctival capillary hemangiomas are rarely reported. Read More

    Orbital infantile hemangioma and rhabdomyosarcoma in children: differentiation using diffusion-weighted magnetic resonance imaging.
    J AAPOS 2017 Nov 4. Epub 2017 Nov 4.
    Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Purpose: To evaluate differences in magnetic resonance imaging (MRI) appearance between infantile hemangiomas and rhabdomyosarcomas of the orbit in pediatric patients using diffusion-weighted imaging.

    Methods: A multicenter retrospective review of MRIs of pediatric patients with infantile hemangiomas and rhabdomyosarcomas of the orbit was performed. MRI examinations from a total of 21 patients with infantile hemangiomas and 12 patients with rhabdomyosarcomas of the orbit were independently reviewed by two subspecialty board-certified neuroradiologists masked to the diagnosis. Read More

    Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in vitro and of tumor growth in vivo.
    Oncol Lett 2017 Nov 18;14(5):6170-6176. Epub 2017 Sep 18.
    Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Yuzhong, Chongqing 400014, P.R. China.
    Artesunate has been demonstrated to be a novel potential antitumor agent in numerous studies. However, its efficacy in infantile hemangioma is unknown. The aim of the present study was to investigate the role of artesunate in the control of vascular tumor biological behavior and molecular mechanism using mouse hemangioendothelioma endothelial (EOMA) cells and a nude mouse model. Read More

    Distributive Shock in a Neonate with Diffuse Infantile Hepatic Hemangioma.
    J Emerg Med 2018 Jan 27;54(1):e1-e3. Epub 2017 Oct 27.
    Childrens Hospital of Michigan, Detroit, Michigan.
    Background: Hemangiomas are common cutaneous findings on healthy infants. These vascular malformations are generally benign, though in rare circumstances they can potentially be fatal. This is particularly true when the hemangiomas are large or numerous and occurring in visceral organs. Read More

    Etiology of pediatric acquired blepharoptosis.
    J AAPOS 2017 Dec 3;21(6):485-487. Epub 2017 Nov 3.
    Royal Victorian Eye and Ear Hospital, East Melbourne, VIC Australia; Department of Ophthalmology, University of Melbourne, Parkville, VIC Australia; Centre for Eye Research Australia, East Melbourne, VIC Australia.
    Purpose: To describe the etiology of acquired pediatric blepharoptosis in a large clinical series and to elucidate the causes of the disease.

    Methods: The medical records of all patients presenting with acquired blepharoptosis at two specialist ocular plastics practices and a pediatric ophthalmology practice during a period of up to 25 years were reviewed retrospectively and classified according to their diagnosis. Patients were grouped into children (<18 years), younger adults (18-40 years), and older adults (>40 years). Read More

    Sporadic Intradural Extramedullary Hemangioblastoma of the Cauda Equina: Case Report and Literature Review.
    World Neurosurg 2018 Jan 28;109:436-441. Epub 2017 Oct 28.
    Department of Neurosurgery, Good Samaritan Regional Medical Center, Corvallis, Oregon, USA.
    Background: Spinal hemangioblastomas account for 1%-5% of all spinal cord tumors. Although spinal hemangioblastomas are rare, it is exceedingly rare to have a case of intradural extramedullary hemangioblastoma of the spine, especially in isolation without von Hippel-Lindau syndrome. The purpose of this report is to present a rare case of intradural extramedullary hemangioblastoma of the cauda equina and a literature review. Read More

    Role of imaging in the diagnosis of parotid infantile hemangiomas.
    Int J Pediatr Otorhinolaryngol 2017 Nov 4;102:61-66. Epub 2017 Sep 4.
    Vascular Anomalies Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Division of Vascular and Interventional Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
    Objectives: To review the clinical presentation, imaging and follow-up of parotid infantile hemangiomas (IH).

    Methods: Over a 15-year period, all patients with a clinical diagnosis of parotid IH were evaluated. Imaging was available in 35. Read More

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