5,991 results match your criteria Infantile Hemangioma

Infantile hemangioma and the risk factors in a Japanese population: A nationwide longitudinal study - The Japan Environment and Children's Study (JECS).

J Invest Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Toyama Regional Center for JECS, University of Toyama, Toyama, Japan; Department of Public Health, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

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Is prolonged monitoring necessary? An updated approach to infantile hemangioma treatment with oral propranolol.

Pediatr Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.

Background/objectives: Infantile hemangiomas (IH) are the most common soft-tissue tumors in childhood, occurring in up to 1 in 10 infants. Oral propranolol has been well established as the first-line treatment of complicated hemangiomas; however, variability in the administration protocol remains. We sought to evaluate our current propranolol treatment protocols to determine if the level of monitoring and follow-up predicts immediate or future adverse events by comparing one in-person visit vs two in-person visits versus teledermatology for treatment initiation and dose escalation. Read More

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Primary and secondary retinal capillary haemangioma in Mexico.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jun 2;96(6):337-341. Epub 2020 Aug 2.

Departamento de Retina & Vítreo, Fundación Hospital "Nuestra Señora de la Luz", I.A.P., Mexico City, Mexico.

A series is presented of sixteen cases of retinal capillary haemangioma (RCH) from consecutive patients at an ophthalmology teaching hospital in Mexico City. There were seven primary haemangioblastomas, and nine due to von Hippel-Lindau disease (VHL). All cases associated with VHL already had systemic manifestations, such as, cerebellar, medullary and renal tumours. Read More

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A Case Report of Multiple Capillary Hemangioma in a Chronic Myeloid Leukemia Patient Taking Tyrosine Kinase Inhibitors.

Ann Dermatol 2021 Jun 4;33(3):278-280. Epub 2021 May 4.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

A capillary hemangioma is a vascular tumor with small capillary sized vascular channel. Multiple capillary hemangioma in relation with drugs have been rarely reported. Here in, we report a case of multiple capillary hemangioma in patient diagnosed with chronic myeloid leukemia who received tyrosine kinase inhibitors (TKIs). Read More

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Dermatol Ther 2021 Jun 2:e15016. Epub 2021 Jun 2.

Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

An increasing use of beta-blockers in dermatology has been described over the last 10 years, despite the fact that their use in diseases other than infantile hemangiomas is off-label. This review discusses the emerging role of topical beta-blockers in the treatment of infantile hemangioma, but also pyogenic granuloma, Kaposi sarcoma, wounds and nail paronychia. Data in literature demonstrate that topical beta-blockers are a safe and valid therapeutic option in numerous cutaneous diseases. Read More

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Cardiac dysfunction associated with consumptive hypothyroidism in a case of hepatic hemangioma: case report.

Endokrynol Pol 2021 May 31. Epub 2021 May 31.

Department of Pediatric, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China, 109 West Xueyuan Road, Wenzhou, Zhejiang 325027, P.R. China, 325027 Zhejiang, China.

Background: Infantile hepatic hemangiomas (IHHs) are the most common liver tumor in infancy. And they have proved to lead to cardiac insufficiency and consumptive hypothyroidism.

Case Presentation: A two-month-old girl had two purple skin lesions. Read More

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Infantile Extracranial Rhabdoid Tumor of the Scalp.

Case Rep Med 2021 11;2021:6682960. Epub 2021 May 11.

Department of Neurosurgery, King Hussein Medical Center, Amman, Jordan.

Extracranial rhabdoid tumor is a rare tumor that can originate in multiple organs, and it is most commonly seen in the kidneys. This tumor has a grave prognosis. We report to the best of our knowledge the first case of infantile scalp extracranial rhabdoid tumor in a 6-month-old male baby who presented with a right parietal scalp mass since the age of 1 month. Read More

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Baseline description of the Spanish Academy of Dermatology infantile haemangioma nationwide prospective cohort. Comparison of patients treated with propranolol in routine clinical practice with previous pivotal clinical trial data.

Actas Dermosifiliogr 2021 May 27. Epub 2021 May 27.

Departamento de Dermatología, Hospital Virgen del Rocío, Sevilla, España; Departamento de Dermatología, Hospital Viamed Santa Ángela de la Cruz, Sevilla, España.

Background: There are several therapeutic options for infantile haemangiomas (IH). Propranolol is used according to a pivotal trial. We aimed to describe the characteristics of IH in clinical practice, including the therapies used, and to compare the characteristics of patients treated with propranolol with those of the trial to assess its external validity. Read More

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Update on infantile hemangioma.

Hye Lim Jung

Clin Exp Pediatr 2021 May 26. Epub 2021 May 26.

Deparment of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

The International Society for the Study of Vascular Anomalies classifies vascular anomalies into vascular tumors and vascular malformations. Vascular tumors are neoplasms of endothelial cells, among which infantile hemangiomas (IHs) are the most common, occurring in 5-10% of infants. Glucose transporter-1 protein expression in IHs differs from that of other vascular tumors or vascular malformations. Read More

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Propranolol for infantile hemangiomas with hyperinsulinemic hypoglycemia.

Pediatr Int 2021 Jun 27;63(6):724-725. Epub 2021 May 27.

Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

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PHACES Syndrome and Associated Anomalies: Risk Associated With Small and Large Facial Hemangiomas.

AJR Am J Roentgenol 2021 May 26:1-8. Epub 2021 May 26.

Department of Medical Imaging, CHU Sainte-Justine, 3175, Cote-Sainte-Catherine, Montreal, QC H3T 1C5, Canada.

PHACES syndrome includes posterior fossa malformations, hemangioma, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities, and sternal defect with or without supraumbilical raphe. Usually, brain imaging is performed when facial hemangiomas are larger than 5 cm. Data on associated anomalies regardless of hemangioma size are sparse. Read More

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Retinal racemose hemangioma (retinal arteriovenous communication) diagnosed and managed with multimodal imaging.

Retin Cases Brief Rep 2021 May 1. Epub 2021 May 1.

Vitreous Retina Macula Consultants of New York, New York, NY, USA Columbia University College of Physicians and Surgeons, New York, NY, USA New York University, Department of Ophthalmology, New York, NY, USA Manhattan Eye, Ear, and Throat Hospital, Lenox Hill Hospital, New York, NY, USA Wilmer Eye Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA Institute of Ophthalmology, Fundación Conde de Valenciana, Mexico City, Mexico Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena University Hospital, Siena, Italy Department of Ophthalmology, Hofstra Northwell School of Medicine, Hempstead, NY, USA.

Purpose: Retinal racemose hemangioma (RRH) is a rare congenital abnormality of the retinal vasculature with a variety of secondary manifestations that can cause vision loss, including macular edema. This report aims to demonstrate the utility of swept-source optical coherence tomography angiography (SS-OCTA) in further characterizing this abnormality.

Methods: Case report with multimodal imaging including SS-OCTA. Read More

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Hemorrhage and secondary infection of an infantile hemangioma during involution: A case report.

Clin Case Rep 2021 May 6;9(5):e03989. Epub 2021 May 6.

Department of Otolaryngology-Head and Neck Surgery University of Arkansas for Medical Sciences Little Rock AR USA.

Bleeding complications due to IHs are generally limited. Secondary abscess formation after hemorrhage has not been reported. Rapid expansion of an IH should raise concern for hemorrhage in IHs that have been an involutionary phase. Read More

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Subglottic ectopic thymus mimicking airway haemangioma.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Paediatric Otolaryngology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Subglottic haemangioma presents as progressive obstruction in the neonatal and infantile airway, with a soft lesion seen during endoscopy. Diagnosis is based on macroscopic findings, biopsy is not usually performed and propranolol is first-line treatment. In contrast, ectopic thymus is a rare differential diagnosis for subglottic mass made by histopathological examination after excision or autopsy. Read More

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Presence of estrogen and progesterone receptors in proliferating and involuting infantile hemangiomas.

J Plast Reconstr Aesthet Surg 2021 Apr 20. Epub 2021 Apr 20.

Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Background: Studies in the literature have demonstrated the presence of sex hormone receptors in infantile hemangiomas (IHs), but further investigation is needed to determine the role of these receptors in their proliferation and involution. To date, there are no studies in the literature that aimed to quantitatively examine the expression of sex hormone receptors throughout the different phases of hemangioma development.

Objective: The objective of our study was to quantitatively evaluate the expression of estrogen (ER) and progesterone (PR) receptors in the proliferative and involuting phases of IHs through the use of real-time polymerase chain reaction (RT-PCR). Read More

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Posterior Mediastinal and Cutaneous Back Hemangiomas in Infants: A New Association.

European J Pediatr Surg Rep 2021 Jan 12;9(1):e37-e40. Epub 2021 May 12.

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Infantile hemangiomas (IHs) are common vascular tumors. In most cases, a benign course with favorable outcome can be anticipated. IH typically present as cutaneous lesions either with a localized or diffuse segmental distribution. Read More

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January 2021

Melanocytes determine angiogenesis gene expression across human tissues.

PLoS One 2021 13;16(5):e0251121. Epub 2021 May 13.

Department of Surgery, Harvard Medical School, The Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Several angiogenesis-dependent diseases, including age-related macular degeneration and infantile hemangioma, display differential prevalence among Black, as compared to White individuals. Although socioeconomic status and genetic architecture have been suggested as explaining these differences, we have recently shown that pigment production per se might be involved. For example, we have shown that the extracellular protein fibromodulin is a pro-angiogenic factor highly secreted by melanocytes in White but not Black individuals. Read More

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Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review.

Am J Ophthalmol Case Rep 2021 Jun 16;22:101095. Epub 2021 Apr 16.

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Purpose: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary to amblyopia.

Observations: We report a case of a two-month-old female infant with a severe deep orbital IH. Read More

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Ultrasonographic features of an intravascular lobular capillary hemangioma originating in the basilic vein: Case report and literature review.

J Clin Ultrasound 2021 May 12. Epub 2021 May 12.

Department of Ultrasound Medicine, West China Hospital, Sichuan University, Chengdu, China.

Intravascular lobular capillary hemangioma (ILCH) is a rare variant of pyogenic granuloma, which develops within the lumen of a blood vessel. Here, we report the case of a 38-year-old male presenting with a mobile, incompressible, nonpulsatile nodule in the superficial fascia of the forearm. A first ultrasonographic examination diagnosed the mass as intravascular thrombosis with partial recanalization. Read More

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Multifocal pleural capillary hemangioma: a rare cause of hemorrhagic pleural effusion-case report.

BMC Pulm Med 2021 May 10;21(1):156. Epub 2021 May 10.

Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Capillary hemangioma can be found in many organs, but rarely in pleura. Previously, only localized pleural capillary hemangioma cases have been reported. Corticosteroids are the most commonly recommended drugs in capillary hemangioma. Read More

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Circular RNA expression profiles in the plasma of patients with infantile hemangioma determined using microarray analysis.

Exp Ther Med 2021 Jun 15;21(6):634. Epub 2021 Apr 15.

Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.

Circular RNAs (circRNAs) are noncoding RNAs that have important roles in tumor progression. Previous studies have examined the circRNAs involved in infantile hemangioma (IH) tumors. The present study compared the circRNA levels in plasma samples from patients with IH and control individuals. Read More

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Evaluation of plasma and urinary levels of vascular endothelial growth factor and matrix metalloproteinase-9 in patients with infantile hemangioma.

Int J Dermatol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.

Background: The pathogenesis of infantile hemangioma (IH) is not fully understood. It has been suggested that angiogenic factors increase in the proliferative stage, decreasing subsequently in the regression phase.

Objectives: To evaluate vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP-9) levels, according to infantile hemangioma (IH) growth stages and size, and to compare these levels in patients with IH and control subjects. Read More

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MiR-206 promotes extracellular matrix accumulation and relieves infantile hemangioma through targeted inhibition of DNMT3A.

Cell Cycle 2021 May 4;20(10):978-992. Epub 2021 May 4.

Department of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.

MiR-206 is abnormally expressed in infant hemangioma endothelial cells (HemECs), but the mechanism is not clear. We explored the intervention of miR-206 in HemECs in relation to extracellular matrix (ECM) metabolism. We selected 48 cases of infantile hemangioma (IH) from volunteer organizations. Read More

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Propranolol for Treatment of Infantile Hemangioma: Efficacy and Effect on Pediatric Growth and Development.

Int J Pediatr 2021 7;2021:6669383. Epub 2021 Apr 7.

Department of Otolaryngology-Head and Neck Surgery, University of Arkansas of the Medical Sciences, 4301 W, St Little Rock, Markham, AR, Canada 72205.

Purpose: Propranolol has been successful in treating problematic infantile hemangiomas (IH) but concerns regarding its effect on normal growth and development have been raised. This study examines physical growth, developmental milestones, and human growth hormone (hGH) levels in infants receiving propranolol for problematic IH.

Method: Monthly heights and weights of children undergoing propranolol therapy for IH were prospectively collected and tabulated. Read More

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Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride.

Pharmaceutics 2021 Apr 19;13(4). Epub 2021 Apr 19.

Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.

Oral propranolol hydrochloride has been the first-line treatment for infantile hemangioma (IH), whereas systemic exposure to propranolol has the potential of causing serious adverse reactions. Dermal delivery of propranolol is preferable due to high local drug concentration and fewer adverse effects. However, propranolol hydrochloride (BCS class I) is highly hydrophilic and has difficulty in penetrating the stratum corneum (SC) barrier. Read More

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Clitoromegaly, Vulvovaginal Hemangioma Mimicking Pelvic Organ Prolapse, and Heavy Menstrual Bleeding: Gynecologic Manifestations of Klippel-Trénaunay Syndrome.

Medicina (Kaunas) 2021 Apr 9;57(4). Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Klippel-Trénaunay Syndrome (KTS) is a genetic vascular malformation involving the capillary, lymphatic, and venous channels. Prenatal sonographic diagnosis of KTS with an enlarged fetal limb is well-known; however, postnatal gynecologic manifestations are rarely reported. KTS can cause clitoromegaly, vulvovaginal hemangioma, and heavy menstrual bleeding. Read More

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[Clinicopathological study of infantile hemangioma].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):508-510

Department of Hemangioma, Henan Provincial People's Hospital, Zhengzhou 450003, China.

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Using Topical Citric Acid to Treat an Infected Ulcerated Hemangioma in an Infant: A Case Study.

Wounds 2021 Feb;33(2):E17-E19

Maharashtra Institute of Medical Sciences and Research (MIMSR) Medical College Latur, India.

Introduction: Infantile hemangiomas (IHs) are the most common vascular abnormalities in children under 1 year old; most IHs involute spontaneously and do not need intervention unless a complication occurs. Ulceration and secondary infection are the most common complications. Despite appropriate conventional wound care, ulcerated IHs are difficult to heal. Read More

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February 2021

Surviving Inhibition Induces Cell Cycle Arrest and Disrupts Multipotency in Haemangioma Stem Cells.

Chin J Dent Res 2021 Apr;24(1):21-31

Objective: To explore the potential therapies for infantile haemangiomas by targeting survivin, a member of the inhibitor of apoptosis protein family, using its specific small molecule inhibitor YM155.

Methods: The expression of survivin in human haemangioma tissue was explored using immunohistochemistry and immunohistofluorescence. Cell cycle analysis and EdU assays were used to measure cell proliferation. Read More

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Primary malignant vascular tumors of the liver in children: Angiosarcoma and epithelioid hemangioendothelioma.

World J Gastrointest Oncol 2021 Apr;13(4):223-230

Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada.

Primary malignant vascular neoplasms of the liver, angiosarcoma and epithelioid hemangioendothelioma, are extremely rare entities in the pediatric population. International Society for the Study of Vascular Anomalies classification system is recommended for the pathologic diagnosis of hepatic vascular lesions in this age group. In this article, we highlight the clinicopathologic characteristics of hepatic angiosarcoma and epithelioid hemangioendothelioma in the pediatric population. Read More

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