6,373 results match your criteria Infantile Hemangioma


Benign Neonatal Hemangiomatosis.

Adv Neonatal Care 2022 Mar 29. Epub 2022 Mar 29.

Center for Clinical Studies, Webster, Texas (Dr Miller); Mercer University School of Medicine, Macon, Georgia (Drs Miller, Gordon, Peterson, and Cohen); Department of Pediatrics, Beverly Knight Olson Children's Hospital, Navicent Health, Macon, Georgia (Drs Gordon and Peterson); Skin Care Physicians of Georgia, Macon, Georgia (Dr Cohen); and Department of Pediatrics, Spartanburg Regional Healthcare System, Spartanburg, South Carolina (Dr Bowe).

Background: Benign neonatal hemangiomatosis (BNH) is a rare, self-limiting subtype of infantile hemangiomas (IHs), in which infants with multiple cutaneous hemangiomas lack visceral involvement. Other subtypes of IHs exist that may mimic BNH and can be life-threatening depending on hemangioma location and size.

Clinical Findings: At birth, a 295/7-week preterm female presented with several pinhead-sized pink papules distributed throughout her body. Read More

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VEGF Pathway Gene Expression Profile of Proliferating versus Involuting Infantile Hemangiomas: Preliminary Evidence and Review of the Literature.

Children (Basel) 2022 Jun 17;9(6). Epub 2022 Jun 17.

Center of Expertise for Rare Vascular Disease in Children, Louis Turcanu Children Hospital, 300041 Timisoara, Romania.

. Infantile hemangiomas may have unexpected behavior. Initial regression (spontaneously or drug-induced) may be followed by unexplained recurrences. Read More

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Successful use of telemedicine for evaluation of infantile hemangiomas during the early COVID-19 pandemic: A cross-sectional study.

Pediatr Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, University of California San Francisco, San Francisco, California, USA.

Background/objectives: The COVID-19 pandemic prompted a rapid expansion in the use of telemedicine. This study aimed to assess the experiences of hemangioma specialists utilizing telemedicine during the COVID-19 pandemic to evaluate and manage infantile hemangiomas (IH), including perceived effectiveness of different modalities and barriers to care delivery.

Methods: Multicenter cross-sectional study asking providers to describe their experiences using telemedicine for initial evaluation of IH from March to September 2020. Read More

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Oral Atenolol versus Propranolol in the Treatment of Infantile Hemangioma: A Systematic Review and Meta-Analysis.

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):279-286. Epub 2022 May 12.

Department of Paediatric Surgery, PGIMER, Chandigarh, India.

Background: Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. Propranolol is considered first-line therapy for IH. However, it is associated with side effects. Read More

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Right gluteal capillary hemangioma: a rare clinical image.

Pan Afr Med J 2022 15;41:214. Epub 2022 Mar 15.

Department of Child Health Nursing, Srimati Radhikabai Meghe Memorial College of Nursing, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India.

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Update on Treatment of Infantile Hemangiomas: What's New in the Last Five Years?

Front Pharmacol 2022 26;13:879602. Epub 2022 May 26.

Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy.

Among benign vascular tumors of infancy, hemangiomas are the commonest, affecting approximately 5-10% of one-year-old children. They are derived from a benign proliferation of vascular endothelial cells (VECs) in the mesoderm and may arise anywhere on the body around 1-2 weeks after birth. Infantile hemangiomas (IHs) are characterized by an early proliferative phase in the first year followed by a spontaneous progressive regression within the following 5 years or longer. Read More

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A Comprehensive Review of Hepatic Hemangioma Management.

J Gastrointest Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Surgery, The Ohio State University Wexner Medical Center, 395 W. 12th Ave., Suite 670, Columbus, OH, USA.

Background: Hepatic hemangiomas (HHs) are benign liver lesions often discovered incidentally on imaging for various unrelated pathologies. We herein review the etiology, classification, diagnostic imaging, and management of HHs.

Methods: A comprehensive systematic review was performed utilizing MEDLINE/PubMed and Web of Science databases, with the end of search date being March 1, 2022, regarding HH diagnosis, imaging, and management. Read More

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Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma.

Pediatr Surg Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Vascular Anomalies and Interventional Radiology, Children's Hospital Affiliated to Shandong University Ji'nan Children's Hospital, Jinan, China.

Purpose: To assess the efficacy of transcatheter arterial embolization (TAE) plus propranolol treatment for infantile hepatic hemangioma (IHH).

Methods: A retrospective study of symptomatic IHH and hemodynamic changes in IHH was conducted between 2016 and 2019.

Results: There were five boys and seven girls with diffuse lesions (n = 7) and multifocal lesions (n = 5). Read More

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Retinal Capillary Hemangioma Leading to a Diagnosis of von Hippel-Lindau Disease in a Patient with Retinopathy of Prematurity.

Case Rep Ophthalmol 2022 May-Aug;13(2):323-329. Epub 2022 May 2.

Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA.

Von Hippel-Lindau (VHL) disease is a rare inherited cancer syndrome that results in the development of tumor formation in multiple systems. In the eye, retinal capillary hemangioma (RCH) can lead to severe vision loss. Retinopathy of prematurity (ROP) is likewise a rare disease in which abnormal retinal vasculature develops in premature infants. Read More

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Spinal kaposiform hemangioendotheliomas: is there a role for endovascular treatment?

Pediatr Neurosurg 2022 Jun 13. Epub 2022 Jun 13.

Kaposiform hemangioendotheliomas (KHE) are rare vascular neoplasms composed of groups of capillaries and endothelial cells, forming aneurysms and arteriovenous fistulas. They occur mainly in the extremities during early childhood or infancy, and although they are locally aggressive, the occurrence of metastases is uncommon. A 9-month-old male infant born with a thoracolumbar cutaneous red lesion presented with progressive loss of strength in lower limbs, evolving with progressive flaccid paraplegia and areflexia. Read More

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Infantile hepatic hemangiomas: looking backwards and forwards.

Precis Clin Med 2022 Mar 11;5(1):pbac006. Epub 2022 Feb 11.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.

Infantile hepatic hemangiomas (IHHs) are common benign tumors seen in the liver of infants. IHHs are true infantile hemangiomas (IHs) and have phases of proliferation and involution parallel to those of cutaneous IHs. The definition and classification of IHH are still confusing in the literature. Read More

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Clinical characteristics of infants with port-wine stain and glaucoma secondary to Sturge-Weber Syndrome.

BMC Ophthalmol 2022 Jun 9;22(1):260. Epub 2022 Jun 9.

Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Sturge-Weber Syndrome (SWS) is a rare disease involving the eye, skin, and brain. Port-wine stain (PWS) and glaucoma are common clinical manifestations. This study analysed the clinical characteristics of infants with PWS and glaucoma secondary to SWS. Read More

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Medical management of vascular anomalies of the head and neck.

J Oral Pathol Med 2022 Jun 6. Epub 2022 Jun 6.

Unité de Dermatologie Pédiatrique et Centre de Référence des Maladies Rares de la Peau d'Origine Génétique, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux cedex, France.

Depending on impairment, treatment of vascular anomalies is decided on a case-by-case basis in pluridisciplinary consultations. Interventional treatments, especially surgery and sclerotherapy, are usually partially efficient and management of patients with vascular anomalies increasingly involves the use of medical drugs. The most common vascular tumor is infantile hemangioma where first-line medical treatment, when necessary, is propranolol. Read More

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Changing Course of an Umbilical Cord Mass - Chasing the Diagnosis of Angiomyxoma.

Pediatr Dev Pathol 2022 Jun 4:10935266221106910. Epub 2022 Jun 4.

Department of Neonatology, 2569Cleveland Clinic, Cleveland, OH, USA.

Angiomyxoma of the umbilical cord is a rare benign vascular malformation with potential for fetal morbidity and mortality. Gross and histologic features of this lesion are identical to those described as "hemangioma," however "angiomyxoma" is a preferable term as current practice restricts the term "hemangioma" to infantile capillary proliferations that express glucose transporter 1. Here we describe the case of an umbilical cord angiomyxoma with associated pseudocysts diagnosed after delivery at 33 weeks. Read More

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Uses of eye drops in dermatology, literature review.

J Dermatolog Treat 2022 Jun 2:1-13. Epub 2022 Jun 2.

Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Since medication absorption through the skin and eye tissue seems similar, commercially available eye-drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable. The FDA-approved and off-label applications of various eye drops used as topical treatments in dermatological clinical practice were highlighted in this review. A thorough PubMed and Google Scholar library search using various combinations of the keywords (Eye drop, ocular solution, conjunctival installation, and skin diseases, topical, local, beta-blockers, prostaglandin, cyclosporin, apraclonidine, atropine, oxymetazoline). Read More

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Case of a Pregnant Woman with Capillary Hemangioma of the Parasellar Region.

NMC Case Rep J 2022 21;9:77-82. Epub 2022 Apr 21.

Department of Neurosurgery, Ichinomiya Municipal Hospital, Ichinomiya, Aichi, Japan.

Here we report a rare case of capillary hemangioma (CH) in a 28-year-old woman suffering from gradual worsening diplopia at 28 weeks of pregnancy. Magnetic resonance imaging (MRI) showed a mass lesion (about 3 cm in diameter) in the right parasellar region. We decided to observe as she was pregnant, and had no symptoms other than right abducent nerve palsy. Read More

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A cerebellar hemangioblastoma and visual and sensory disturbances presenting post partum.

Lancet 2022 05;399(10340):2065

Division of Neurosurgery, University of Connecticut Health Center, UConn Health, Farmington, CT, USA. Electronic address:

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Treatment response, survival, and safety profile of camrelizumab plus apatinib regimen as third-line treatment in metastatic gastric cancer patients.

Clin Res Hepatol Gastroenterol 2022 May 27:101962. Epub 2022 May 27.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address:

Background: Camrelizumab, as a PD-1 inhibitor on the market recently, presents favorable therapeutic efficacy in several advanced cancers, while its application in metastatic gastric cancer (mGC) lacks data. This study aimed to assess treatment response, survival profile, and adverse events of camrelizumab plus apatinib regimen as third-line treatment in mGC patients.

Methods: Nineteen mGC patients who received camrelizumab plus apatinib as third-line treatment were analyzed in this observational study. Read More

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Immunohistochemistry for FOSB and FOS is a Useful Ancillary Tool in the Diagnosis of Epithelioid Hemangioma but There are Pitfalls in Interpretation Including Expression in Other Vascular Lesions.

Int J Surg Pathol 2022 May 29:10668969221101867. Epub 2022 May 29.

91854Douglass Hanly Moir Pathology, Sonic Healthcare, Macquarie Park, Australia.

Epithelioid hemangioma is a benign vascular neoplasm associated with FOS and/or FOSB protein overexpression detected by immunohistochemistry (IHC). The aim of our study was to determine the co-expression or independent IHC expression of FOS and FOSB in a cohort of epithelioid hemangiomas. We also included two cohorts of other vascular lesions: papillary endothelial hyperplasia and lobular capillary hemangioma / pyogenic granuloma. Read More

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Diagnostic dilemma in an infant with stridor: ultrasound to the rescue!

Emerg Radiol 2022 May 27. Epub 2022 May 27.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Room No. 81c, New Delhi, 110029, India.

Stridor is one of the most important signs of partial or complete upper airway obstruction. Subglottic hemangioma (SGH) is a well-recognized however infrequent cause of infantile stridor. It is a potentially life-threatening condition. Read More

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Intracranial extension of an intramuscular haemangioma of superior rectus: case report and literature review.

BMC Ophthalmol 2022 May 23;22(1):232. Epub 2022 May 23.

Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Background: Intramuscular haemangiomas are rare, benign vascular tumours that represent < 1% of all haemangiomas. When involving the extraocular muscles, haemangiomas are extremely rare, with only nine cases reported in the literature; to date there are no reported cases of extraocular muscle haemangiomas extending into the brain.

Case Presentation: A 6-year-old boy with a two-week history of a painless swelling and erythema on the upper eyelid. Read More

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Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma.

Front Pediatr 2022 2;10:849496. Epub 2022 May 2.

Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background And Purpose: This study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of propranolol, β1-AR mutation and CYP2D6 188C>T, efficacy, and safety.

Experimental Approach: From January 2018 to April 2019, 140 patients with IH who were admitted to the hospital for oral propranolol and agreed to have their plasma concentration of propranolol tested, including 112 patients with β1-AR and CYP2D6 gene tested.

Key Results And Conclusions And Implications: The mean peak blood levels of propranolol, 4-hydroxypropranolol (4-OH-P), and N-deisopropylpropranolol (NDP) were 60. Read More

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Clinical Outcomes of Small Infantile Hemangiomas Treated With Pulsed Dye Laser.

Dermatol Surg 2022 May 17. Epub 2022 May 17.

Department of Plastic and Reconstructive Surgery, Yokohama City University Hospital, Yokohama, Japan.

Background: Infantile hemangioma (IH) often causes cosmetic disfigurement. Early intervention with propranolol for large, high-risk lesions is recommended in the American Academy of Pediatrics' Clinical Practice Guideline. Conversely, strategies for the management of small, low-risk lesions have not been established; however, pulsed dye laser (PDL) is often used to treat these lesions. Read More

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Efficacy of intravenous propranolol for life-threatening diffuse neonatal hemangiomatosis.

Pediatr Dermatol 2022 May 16. Epub 2022 May 16.

Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Oral propranolol is recommended as the first-line agent for infantile hemangioma requiring systemic treatment. Life-threatening complications such as obstructive infantile hemangioma of the airway or infantile hepatic hemangioma associated with high-output congestive heart failure are major indications for the consideration of early treatment. We present the case of an infant with life-threatening diffuse neonatal hemangiomatosis, including airway obstruction due to subglottic hemangioma, heart failure due to multiple hepatic hemangiomas with portohepatic venous shunts, and severe anemia due to continuous gastrointestinal bleeding, in which treatment with intravenous propranolol proved successful. Read More

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Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System.

Front Surg 2022 27;9:868187. Epub 2022 Apr 27.

Gillies McIndoe Research Institute, Wellington, New Zealand.

Cells exhibiting embryonic stem cell (ESC) characteristics have been demonstrated in vascular anomalies (VAs), cancer, and fibroproliferative conditions, which are commonly managed by plastic surgeons and remain largely unsolved. The efficacy of the mTOR inhibitor sirolimus, and targeted therapies that block the Ras/BRAF/MEK/ERK1/2 and PI3KCA/AKT/mTOR pathways in many types of cancer and VAs, further supports the critical role of ESC-like cells in the pathogenesis of these conditions. ESC-like cells in VAs, cancer, and fibroproliferative conditions express components of the renin-angiotensin system (RAS) - a homeostatic endocrine signaling cascade that regulates cells with ESC characteristics. Read More

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Flexor digitorum profundus tendon infiltration by post-traumatic hemangioma. A pediatric case.

Hand Surg Rehabil 2022 May 13. Epub 2022 May 13.

Department of Orthopedics and Traumatology, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Université libre de Bruxelles, 808 Lennik str., 1070 Bruxelles, Belgium.

Pediatric cases of post-traumatic hemangioma of the palm are rare. Clinical evaluation and imaging are sometimes ambiguous and surgical exploration may show more conclusive results. This case report discusses the diagnosis and treatment of a teenager with post-traumatic hemangioma infiltrating the flexor digitorum profundus tendon of the index finger. Read More

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A New Nonlinear Photothermal Iterative Theory for Port-Wine Stain Detection.

Int J Environ Res Public Health 2022 05 5;19(9). Epub 2022 May 5.

Shaanxi Key Laboratory of Ultrasound, School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China.

The development of appropriate photothermal detection of skin diseases to meet complex clinical demands is an urgent challenge for the prevention and therapy of skin cancer. An extensive body of literature has ignored all high-order harmonics above the second order and their influences on low-order harmonics. In this paper, a new iterative numerical method is developed for solving the nonlinear thermal diffusion equation to improve nonlinear photothermal detection for the noninvasive assessment of the thickness of port-wine stain (PWS). Read More

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Is Infantile Hemangioma a Neuroendocrine Tumor?

Int J Mol Sci 2022 May 5;23(9). Epub 2022 May 5.

BRIC, UMR 1312, Inserm, University Bordeaux, F-33076 Bordeaux, France.

Infantile hemangioma (IH) is the most common infantile tumor, affecting 5-10% of newborns. Propranolol, a nonselective β-adrenergic receptor (ADRB) antagonist, is currently the first-line treatment for severe IH; however, both its mechanism of action and its main cellular target remain poorly understood. Since betablockers can antagonize the effect of natural ADRB agonists, we postulated that the catecholamine produced in situ in IH may have a role in the propranolol response. Read More

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