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    1 OF 98

    The expression and function of miR-424 in infantile skin hemangioma and its mechanism.
    Sci Rep 2017 Sep 19;7(1):11846. Epub 2017 Sep 19.
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
    Infantile hemangioma is the most common benign tumor in infants. Many studies have confirmed that basic fibroblast growth factor (bFGF) and its key receptor FGFR1 are highly expressed in hemangioma. Moreover, several miRNAs can regulate angiogenesis. Read More

    Atenolol treatment for severe Infantile Hemangiomas: a single-centre prospective study.
    J Eur Acad Dermatol Venereol 2017 Sep 18. Epub 2017 Sep 18.
    First Department of Pediatrics, University of Athens, Aghia Sofia" Children's Hospital, Athens, Greece.
    Infantile hemangiomas (IHs) are common benign vascular tumors of infancy with an incidence of 4-5% (1) . The majority of IHs are self-limited, though in approximately 10% of patients, when their lesions compromise vital and sensory functions or cause disfigurement, medical treatment is warranted (2,3) . Τhe most exciting development in the treatment for IHs over the last decade has been the discovery of propranolol's effects during the proliferative phase of the hemangioma cycle (4) . Read More

    Inhibition of hemangioma growth using polymer-lipid hybrid nanoparticles for delivery of rapamycin.
    Biomed Pharmacother 2017 Sep 9;95:875-884. Epub 2017 Sep 9.
    Department of Vascular Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefangdadao Road, Wuhan 430022, Hubei, China. Electronic address:
    Although infantile hemangiomas is benign, its rapid growth may induce serious complications. However, only one drug Hemangeol™ has been approved by US Food and Drug Administration (FDA) to treat infantile hemangiomas. Thus it is necessary to develop novel alternative drugs to treat infantile hemangiomas. Read More

    Exploring the association between chorangioma and infantile haemangioma in singleton and multiple pregnancies: a case-control study in a Swedish tertiary centre.
    BMJ Open 2017 Sep 3;7(9):e015539. Epub 2017 Sep 3.
    Section of Perinatal Pathology, Department of Pathology, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Objectives: Placenta or placental chorangioma could be the origin site of infantile haemangioma since they share various histochemical and genetic characteristics with placental vascular tissue. The aim of the current study was to investigate the association between chorangiomas and infantile haemangiomas in singleton and multiple pregnancies.

    Materials And Methods: An informative questionnaire enquiring about the presence or not of infantile haemangioma and including illustrative photos of haemangioma was sent to 469 (153 cases with chorangioma and 316 controls) mothers of 323 singleton (104 cases and 219 controls) and 146 multiple (49 cases and 97 controls) liveborn neonates registered in Sweden. Read More

    Treatment of Refractory Infantile Hemangiomas and Pulmonary Hypertension With Sirolimus in a Pediatric Patient.
    J Pediatr Hematol Oncol 2017 Aug 30. Epub 2017 Aug 30.
    Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI.
    Infantile hemangioma is a benign vascular neoplasm that spontaneously involutes over time. Management, when needed, consists of medications, laser treatment and surgical excision. We describe a 3-year-old girl who presented shortly after birth with diffuse cutaneous hemangiomas, hepatosplenomegaly with liver lesions, anemia, and acute heart failure. Read More

    Survivin: A novel marker and potential therapeutic target for human angiosarcoma.
    Cancer Sci 2017 Aug 28. Epub 2017 Aug 28.
    Division of Cancer Biology, National Cancer Center Research Institute, Tokyo, Japan.
    Human angiosarcoma is a rare malignant vascular tumor associated with extremely poor clinical outcome and generally arising in skin of the head and neck region. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechanisms of angiosarcoma progression, we collected 85 cases of human angiosarcoma specimens with clinical records and analyzed ISO-HAS-B patient-derived angiosarcoma cells. Read More

    Prevalence and pattern of lobular capillary hemangioma in Eastern Madhya Pradesh, India: A clinicopathological analysis.
    Indian J Dent Res 2017 Jul-Aug;28(4):424-428
    Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
    Background: Lobular capillary hemangioma is a common benign vascular tumor seen in the oral cavity. It occurs in response to various stimuli such as low-grade local irritation, traumatic insult, and hormonal factors or as a response to a wide variety of drugs.

    Materials And Methods: All patients presenting to the Department of Dentistry, Shyam Shah Medical College, Rewa, Madhya Pradesh during July 2014 to June 2016, who were diagnosed by histopathologic confirmation as oral lobular capillary hemangioma (OLCH), were evaluated for the area involved, clinicopathologic presentation, demographic features, and treatment. Read More

    Intradural-extramedullary capillary hemangioma with acute bleeding, case report and literature review.
    World Neurosurg 2017 Aug 17. Epub 2017 Aug 17.
    Capillary hemangiomas are benign vascular tumors. They are commonly founded in the vertebral bodies but very seldom in the spinal cord. The most common symptom at onset is long-lasting axial pain without neurologic deficit. Read More

    Use of the Hemangioma Severity Scale to facilitate treatment decisions for infantile hemangiomas.
    J Am Acad Dermatol 2017 Aug 14. Epub 2017 Aug 14.
    Department of Dermatology, Hecovan Expertise-Center for Hemangioma and Vascular Malformations, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: The Hemangioma Severity Scale (HSS) assesses the severity of an infantile hemangioma (IH).

    Objective: First, to compare HSS scores between patients with IH for whom propranolol treatment was indicated at their first visit and those who were not treated. Second, to assess suitable cutoff values for the need for propranolol treatment. Read More

    Unexpected Effect of Propranolol and Prednisolone on Infantile Facial Rhabdomyosarcoma.
    J Pediatr Hematol Oncol 2017 Aug 14. Epub 2017 Aug 14.
    *Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal †Division of Plastic Surgery, San Diego School of Medicine, University of California, Frankfurt am Main ‡Institute for Dermatopathology, Friedrichshafen, Germany.
    A 14-month-old Nepalese infant had developed a rapidly growing facial tumor originating from a dark spot on her upper eyelid. A cavernous hemangioma was suspected and treated with high doses of propranolol and prednisolone. Remission was dramatic. Read More

    Anastomosing haemangioma of liver: A case report.
    Mol Clin Oncol 2017 Sep 24;7(3):507-509. Epub 2017 Jul 24.
    Department of Radiology, Shanghai Jing'an District Centre Hospital, Shanghai 200040, P.R. China.
    Anastomosing haemangioma (AH) is a recently described, unusual variant of capillary hemangioma that appears to be unique to the genitourinary system, with a particular proclivity for the kidney. AH is a subtype of capillary haemangioma, which is rarely encountered in clinical practice, particularly in the liver. We herein present the case of a 57-year-old woman with an incidental finding on magnetic resonance imaging of a local lesion in the liver, sized 3. Read More

    Study of Cognitive Function in Children Treated with Propranolol for Infantile Hemangioma.
    Pediatr Dermatol 2017 Sep 14;34(5):554-558. Epub 2017 Aug 14.
    Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain.
    Background: Oral propranolol is considered the first choice for the treatment of infantile hemangiomas (IHs). There is a concern that administering propranolol in newborns and infants could induce adverse effects in learning and memory processes in the long term. The purpose of this study was to assess cognitive and memory functions in children who had been treated with propranolol for IH during their infancy. Read More

    Different Clinical Features of Acral Abortive Hemangiomas.
    Case Rep Dermatol Med 2017 12;2017:2897617. Epub 2017 Jul 12.
    Department of Pediatric Surgery, Hospital Universitario Central de Asturias, Oviedo, Spain.
    Some infantile hemangiomas called in literature "minimal or arrested growth hemangiomas" or "abortive hemangiomas" are present at birth and have a proliferative component equaling less than 25% of its total surface area. Often, they are mistaken for vascular malformation. We present five patients (three girls and two boys) with abortive hemangiomas diagnosed between January 2010 and December 2015 localized in acral part of the extremities. Read More

    Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 1: classification, sonographic approach and vascular tumors.
    Pediatr Radiol 2017 Aug 4;47(9):1184-1195. Epub 2017 Aug 4.
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
    Sonography can be used in the management of pediatric soft-tissue vascular anomalies for diagnosing, for assessing lesion extent and for evaluating complications and response to therapy. The sonographic technique includes a combination of gray-scale imaging with color and spectral Doppler techniques. However the interpretation of the sonographic findings requires correlation with the clinical findings, some of which can be easily obtained at the time of scanning. Read More

    [Tufted angiomas of the head and neck. German version].
    HNO 2017 Jul 31. Epub 2017 Jul 31.
    Klinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
    Background: Tufted angiomas (TAs) are uncommon benign vascular tumors mostly located cutaneously or subcutaneously in the skin of the neck and upper trunk, which appear during childhood and grow slowly. TAs are a variant of lobular capillary hemangiomas. This is the first study to provide an overview of the current literature in combination with the authors' own clinical experience on this rare entity in the head and neck area with non-dermatological localization. Read More

    Spinal capillary hemangiomas: Two cases reports and review of the literature.
    Asian J Neurosurg 2017 Jul-Sep;12(3):556-562
    Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
    Hemangiomas have rarely been found in the spinal cord. A few cases of spinal capillary hemangioma have been reported since 1987. The authors reported the two cases of capillary hemangioma including the tumor at conus medullaris and the another mimicked von Hippel-Lindau disease. Read More

    Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-α for infantile hemangioma.
    Cancer Manag Res 2017 7;9:279-286. Epub 2017 Jul 7.
    Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute.
    Background: Infantile hemangiomas (IHs) are the most common benign vascular tumor of infancy. They occur more frequently in female infants. The cause of hemangioma is currently unknown; however, current studies suggested the importance of estrogen (E2) signaling in hemangioma proliferation. Read More

    [Small intestinal cavernous hemangioma causing chronic hemorrhage: a case report].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Jul;37(7):866-868
    Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China.E-mail:
    Small intestinal hemangioma is a rare condition that can be divided histologically into capillary, cavernous or mixed types, among which the cavernous type is the most common. Here we report a case of small intestinal cavernous hemangioma with chronic hemorrhage in 44-year-old man. The patient complained of weakness and dizziness for 2 years that aggravated 1 month before admission accompanied by intermittent melena. Read More

    In Vivo Microvascular Pattern of Solitary Juxtapapillary Capillary Hemangioma on OCT Angiography.
    Ophthalmic Surg Lasers Imaging Retina 2017 Jul;48(7):592-595
    Juxtapapillary capillary hemangioma (JCH) is a vascular hamartoma. Fluorescein fundus angiography aids in diagnosis. The vascular morphology of this tumor has not been documented with optical coherence tomography angiography (OCTA), a new, noninvasive diagnostic modality that provides high-resolution images of vascular pattern based on blood flow in the retina and choroid. Read More

    Simple Preparation of Timolol 0.5% Gel from Eye Drop Solution for Superficial Infantile Hemangiomas.
    Int J Pharm Compd 2017 Jul-Aug;21(4):282-289
    National Skin Centre Pte. Ltd., Singapore.
    The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Read More

    microRNA-143 acts as a suppressor of hemangioma growth by targeting Bcl-2.
    Gene 2017 Sep 14;628:211-217. Epub 2017 Jul 14.
    Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    Infantile hemangioma is the most common vascular tumor affecting infants, which is associated with clonal expansion of endothelial cells. The aim of this study is to determine the role of microRNA (miR)-143 in the growth and survival of hemangioma-derived endothelial cells (HemECs). We examined the expression of miR-143 in patients with proliferating-phase (n=10) and involuting-phase (n=8) hemangiomas. Read More

    Spinal epidural capillary hemangioma: A rare case report with a review of literature.
    Surg Neurol Int 2017 21;8:123. Epub 2017 Jun 21.
    Department of Neuropathology, NIMHANS, Bengaluru, Karnataka, India.
    Background: Purely epidural capillary hemangiomas are very rare. There are only 6 such reports.

    Case Description: A 50-year-old male presented with a progressive lower extremity paraparesis. Read More

    Posttraumatic Progressive Vertebral Hemangioma Induced by a Fracture.
    Case Rep Surg 2017 20;2017:8280678. Epub 2017 Jun 20.
    Department of Neurosurgery, Bahçeşehir University Faculty of Medicine, Istanbul, Turkey.
    The authors present an extremely rare case of an aggressive and progressive vertebral capillary hemangioma of the lumbar spine secondary to a trauma. A 40-year-old man who complained of back and leg pain due to a hemangioma of L1 that had begun a year after the fracture of the same vertebra was subsequently operated on. Due to the profuse bleeding, only a subtotal removal was possible. Read More

    M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression.
    Am J Pathol 2017 Sep 12;187(9):2102-2111. Epub 2017 Jul 12.
    Center for Regenerative Medicine, Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Division of Hematology/Oncology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:
    Infantile hemangiomas are benign tumors of vascular endothelial cells (ECs), characterized by three distinct stages: proliferating phase, involuting phase, and involuted phase. The mechanisms that trigger involution of hemangioma into fibro-fatty tissue remain unknown. We report a novel mechanism by which M1-polarized macrophages induce endothelial-to-mesenchymal transition (EndMT) and promote hemangioma regression. Read More

    Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis.
    Korean J Spine 2017 Jun 30;14(2):57-60. Epub 2017 Jun 30.
    Department of Neurosurgery, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.
    Capillary hemangiomas are common benign vascular tumors on skin and soft tissues, but developing as an intradural and extramedullary (IDEM) tumor in spine is extremely rare. In this report, we present IDEM tumor compressing thoracic cord in T2-3 level with extensive arachnoiditis below the tumor level in a 60-year-old man. The lesion was removed and histological diagnosis was capillary hemangioma. Read More

    Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma.
    Front Oncol 2017 27;7:137. Epub 2017 Jun 27.
    Department of Interventional Therapy, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0. Read More

    Congenital Progressive Mutilating Hemangioma.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):395-396. Epub 2017 Jun 11.
    "Onkoderma" - Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    A 73-year-old male patient was admitted with symptoms of decompensated cardiac and pulmonary insufficiency with long-lasting history. A tumor-like formation was observed within the clinical examination, covering the whole skin of the nose, paranasal region of the left part of the face, as well as the upper and lower left eyelids. The lesion was with yellow to brownish surface and dark-reddish to violet discolored peripheral area, composed of nodular formations, smooth central surface and firm texture on palpation. Read More

    Clinical Evaluation of Color Doppler Ultrasound in Selecting the Optimal Treatment Modality for Infantile Hemangioma.
    Chin Med Sci J 2017 06;32(2):100-6
    Department of Dermatology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
    Objective We investigated the efficacy and safety of 1064 nm Nd: YAG laser, intense pulsed light (IPL), and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler ultrasound guidance in choosing the optimal treatment modality. Methods Infantile patients who were clinical diagnosed as hemangiomas were randomly divided into group A, who had color Doppler ultrasound examinations before the treatment, and group B who had the treatment without ultrasound evaluation. Patients in the group A were assigned into subgroups according to the depth of lesion by sonography: group A-1 for those who had a lesion depth <1. Read More

    [Usage and efficacy of timolol maleate eye drops in treatment of superficial infantile hemangioma].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Jun;42(6):657-661
    Department of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To determine drug dose and usage of timolol maleate eye drops in the treatment of superficial infantile hemangioma.
 Methods: A total of 250 superficial hemangioma infants were recruited and assigned into 5 groups (n=50 for each group): an external application group and 4 exterior coating groups (2, 4, 6, 8 times per day). We evaluated the therapeutic effect of different methods for drug application (external application or exterior coating) and the frequency for drug administration on superficial infantile hemangioma. Read More

    RNF213 variants in a child with PHACE syndrome and moyamoya vasculopathy.
    Am J Med Genet A 2017 Sep 7;173(9):2557-2561. Epub 2017 Jul 7.
    Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Segmental infantile hemangiomas (IH) can be associated with congenital anomalies in a regional distribution. PHACE refers to large cervicofacial segmental IH in association with congenital anomalies of the aortic arch and medium-sized arteries of the head and neck, as well as structural anomalies of the posterior fossa and eye. A subset of PHACE patients have arterial anomalies that progress to moyamoya vasculopathy (MMV). Read More

    Infantile hemangiomas with minimal or arrested growth associated with soft tissue hypertrophy: a case series of 10 patients.
    J Eur Acad Dermatol Venereol 2017 Jul 5. Epub 2017 Jul 5.
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
    Background: Infantile hemangiomas with minimal or arrested growth (IH-MAGs) are characterized by a proliferative component of <25% of its surface area. The co-occurrence of IH-MAGs and soft tissue anomalies is rare, and case series of this association are lacking.

    Objective: We present 10 cases of IH-MAGs associated with soft tissue hypertrophy and describe their clinical features. Read More

    Incidence, Treatment Patterns, and Health Care Costs of Infantile Hemangioma: Results of a Retrospective German Database Analysis.
    Pediatr Dermatol 2017 Jul 4;34(4):450-457. Epub 2017 Jul 4.
    Pierre Fabre Pharma, Freiburg, Germany.
    Objectives: To determine the incidence, effect (defined according to treatment rate), and health care costs of infantile hemangiomas (IHs) in Germany from 2007 to 2012 by analyzing patient data of German statutory health insurances.

    Methods: A retrospective analysis using data from a database matched with the overall population covered by German statutory health insurance was performed. To describe the treatment rate and costs of IHs, a search algorithm was developed dividing the study population into three groups (patients with IHs, patients with IHs possibly requiring treatment, and patients with IHs receiving treatment). Read More

    Tufted angiomas of the head and neck.
    HNO 2017 Jun 30. Epub 2017 Jun 30.
    Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background: Tufted angiomas (TAs) are uncommon benign vascular tumors mostly located cutaneously or subcutaneously in the skin of the neck and upper trunk, which appear during childhood and grow slowly. TAs are a variant of lobular capillary hemangiomas. This is the first study to provide an overview of the current literature in combination with the authors' own clinical experience on this rare entity in the head and neck area with non-dermatological localization. Read More

    Intraosseous hemangioblastoma of the cervical spine: case report.
    J Neurosurg Spine 2017 Sep 30;27(3):312-315. Epub 2017 Jun 30.
    Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
    A 69-year-old woman presented with bilateral upper-extremity radiculopathy and neck pain after a mechanical fall. Admission CT and MRI of the cervical spine demonstrated a pathological C-4 fracture. Subsequent malignancy workup was negative. Read More

    Repurposing propranolol as a drug for the treatment of retinal haemangioblastomas in von Hippel-Lindau disease.
    Orphanet J Rare Dis 2017 Jun 29;12(1):122. Epub 2017 Jun 29.
    Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
    Background: Von Hippel-Lindau (VHL) disease is a rare oncological disease with an incidence of 1:36,000, and is characterized by the growth of different types of tumours. Haemangioblastomas in the central nervous system (CNS) and retina, renal carcinoma and pheochromocytomas are the most common tumours. The absence of treatment for VHL leads to the need of repeated surgeries as the only option for these patients. Read More

    Update on classification and diagnosis of vascular malformations.
    Curr Opin Pediatr 2017 Aug;29(4):448-454
    CHU Sainte-Justine, University of Montreal, Montreal, Québec, Canada.
    Purpose Of Review: This review provides an update of the classification in the classification of vascular anomalies since April 2014 at the International Society for the Study of Vascular Anomalies meeting in Melbourne, Australia.

    Recent Findings: The reader will become familiar with how to diagnose the major vascular malformations, including capillary, venous, arteriovenous, and lymphatic and combinations thereof. In addition, vascular malformation syndromes, including those with overgrowth, will be clarified. Read More

    BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications.
    Arch Soc Esp Oftalmol 2017 Jun 23. Epub 2017 Jun 23.
    Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia (Cáceres), España.
    Case Report: A 45 year-old man with a history of adrenal phaeochromocytoma presented with a subretinal juxtapapillary haemorrhage on his left eye and a small asymptomatic vascular tumour in the contralateral eye. With the mentioned findings, the patient was diagnosed with bilateral retinal capillary haemangioma in the context of a von Hippel Lindau disease. Intravitreal aflibercept was prescribed, with a good outcome of the disease. Read More

    Tissue and serum mRNA profile of MMPs-2/9 as a potential novel biomarker for the most individual approach in infantile hemangiomas and cancer disease.
    Immunobiology 2017 Nov 3;222(11):1035-1042. Epub 2017 Jun 3.
    Department of Pediatric Surgery and Oncology, Central Clinical Hospital of Medical University of Lodz, Konopnicka Memorial Pediatric Center, ul. Sporna 36/50, 91-738 Lodz, Poland.
    Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propranolol influences their pathways. Read More

    [Pediatric salivary gland tumors and tumor-like lesions].
    Pathologe 2017 Jul;38(4):294-302
    Klinik für Hals‑, Nasen- und Ohrenheilkunde (HNO), Klinikum Augsburg, Sauerbruchstraße 6, 86156, Augsburg, Deutschland.
    Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Read More

    Circulating Levels of Vascular Endothelial Growth Factor and Basic Fibroblastic Growth Factor in Infantile Hemangioma Versus Vascular Malformations.
    Clin Appl Thromb Hemost 2017 Jan 1:1076029617710333. Epub 2017 Jan 1.
    2 Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Few preliminary reports studied the utility of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) for differentiation between infantile hemangiomas (IHs) and vascular malformations. The aim of this study was to investigate the role of serum VEGF and bFGF levels in differentiating IHs from vascular malformations and identifying the stage and clinical course of IHs. Serum levels of VEGF and bFGF were assessed in 60 infants and children with various cutaneous vascular anomalies defined in 3 groups: proliferating IHs (n = 25), involuting IHs (n = 23), and vascular malformations (n = 12), in comparison with their levels in 40 healthy matched control. Read More

    Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence.
    Clin Case Rep 2017 Jun 24;5(6):887-890. Epub 2017 Apr 24.
    Department of PediatricsMakassed General HospitalBeirutLebanon.
    Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. However, diffuse hepatic hemangioma can develop even in patients with single cutaneous hemangioma. This highlights the importance of physical examination and screening ultrasound in these patients. Read More

    Sildenafil suppresses the proliferation and enhances the apoptosis of hemangioma endothelial cells.
    Exp Ther Med 2017 Jun 5;13(6):2645-2650. Epub 2017 Apr 5.
    Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
    Treatment of infantile hemangiomas (IH) with propranolol was first reported in 2008. Regressions of lymphatic malformations combined with pulmonary hypertension was first reported in 2012 after three children received treatment with oral sildenafil, which serves as an antagonist of phosphodiesterase isoform-5 (PDE-5). A marked expression of endothelial cells in the cytoplasm of IH tissues was obtained in our previous study. Read More

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