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    1 OF 96

    Interdisciplinary Management of Head and Neck Vascular Anomalies: Clinical Presentation, Diagnostic Findings and Minimalinvasive Therapies.
    Eur J Radiol Open 2017 14;4:63-68. Epub 2017 May 14.
    Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
    Objectives: Vascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Read More

    Infantile Periocular Hemangioma.
    J Ophthalmic Vis Res 2017 Apr-Jun;12(2):205-211
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Infantile periocular hemangiomas (IPH) are common benign vascular tumors that present early in childhood. They typically show a rapid nonlinear growth pattern a few weeks after birth during a proliferative phase, then continue with an involution phase and may result in serious ocular or systemic complications. Theses tumors may present in a range of small isolated lesions to multiple, diffuse involvements. Read More

    Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation.
    Plast Reconstr Surg 2017 Jun;139(6):1277e-1284e
    Columbus, Ohio From the Department of Plastic Surgery, the Department of Biomedical Informatics, Center for Biostatistics, the Department of Surgery, and the Divisions of Vascular Surgery and General Surgery, The Ohio State University; and the Department of Pediatrics, the Hemangioma and Vascular Malformation Clinic, and the Department of Pediatrics, Division of Dermatology, Nationwide Children's Hospital.
    Background: Hemangiomas are unique endothelial cell tumors that involute spontaneously, which makes interpreting their response to therapies difficult. The objective of this work was to identify a potential biomarker in the urine of children with infantile hemangiomas that would facilitate testing new therapies.

    Methods: A prospective longitudinal study in children with hemangiomas and age-matched healthy controls was performed to determine whether microRNA-126, which is highly abundant in fetal endothelial cells, was more abundant in the urine of affected children. Read More

    PARAFOVEAL MICROVASCULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CIRCUMSCRIBED CHOROIDAL HEMANGIOMA.
    Retina 2017 May 19. Epub 2017 May 19.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Purpose: To evaluate parafoveal microvasculature in eyes with circumscribed choroidal hemangioma using optical coherence tomography angiography.

    Methods: Fourteen eyes with unilateral circumscribed choroidal hemangioma were imaged using OCT for central macular thickness and optical coherence tomography angiography for superficial and deep foveal avascular zone area, and superficial and deep capillary density (CD), comparing affected and paired fellow eyes.

    Results: Mean patient age was 53 years, and mean visual acuity was 20/60 in the involved eye and 20/25 in the fellow eye. Read More

    Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique.
    Oncol Lett 2017 May 13;13(5):2937-2944. Epub 2017 Mar 13.
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
    Hemangioma is one of the most common types of infantile vascular benign tumor. The aim of the present study was to investigate the role of B-cell lymphoma 2 (Bcl-2) and tumor protein p53 (p53) in the proliferation and apoptosis of hemangioma cells. A total of 38 paraffin-embedded hemangioma specimens (16 males and 22 females) and another 5 paraffin-embedded healthy surrounding tissue samples, collected between January 2007 and December 2010, were obtained from the Department of Pathology at Renmin Hospital of Wuhan University (Wuhan, China). Read More

    Management of a Life Threatening Bleeding Following Extraction of Deciduous Second Molar Related to a Capillary Haemangioma.
    Craniomaxillofac Trauma Reconstr 2017 Jun 16;10(2):166-170. Epub 2017 Mar 16.
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
    Various forms of vascular lesion affect the head and neck region. The head and neck vascular lesions are classified into neoplasms and malformations. Neoplasm presents either as hemangioma or lymphangioma; neoplasm usually presents in young age compared with vascular malformation. Read More

    Clinical case series of pediatric hepatic angiosarcoma.
    Pediatr Blood Cancer 2017 May 18. Epub 2017 May 18.
    Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
    Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Read More

    Arrested Development: Infantile Hemangioma and the Stem Cell Teratogenic Hypothesis.
    Lymphat Res Biol 2017 May 18. Epub 2017 May 18.
    4 Department of Medicine, New York University School of Medicine , New York, New York.
    Background: Early-life programming is defined by the adaptive changes made by the fetus in response to an adverse in utero environment. Infantile hemangioma (IH), a vascular anomaly, is the most common tumor of infancy. Here we take IH as the tumor model to propose the stem cell teratogenic hypothesis of tumorigenesis and the potential involvement of the immune system. Read More

    Use of propranolol in a remote region of rural Guatemala to treat a large facial infantile haemangioma.
    BMJ Case Rep 2017 May 16;2017. Epub 2017 May 16.
    Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    We present a female infant with a right-sided facial and neck haemangioma, from a remote, resource-poor community in rural Guatemala. She received first-line treatment, propranolol, with marked reduction in tumour size and erythema. Treatment was stopped after 35 weeks due to recurrent diarrhoea and sustained weight loss. Read More

    Propranolol therapy for infantile hemangioma: our experience.
    Drug Des Devel Ther 2017 8;11:1401-1408. Epub 2017 May 8.
    Department of Oral-Maxillary Head and Neck, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai.
    Objective: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas. Read More

    Cardiac hemangioma caused ventricular arrhythmia: A rare case and literature review.
    J Electrocardiol 2017 May 3. Epub 2017 May 3.
    Department of Cardiovascular Ultrasound, First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:
    Cardiac hemangioma is a rare primary cardiac tumor. We reported the case of patient with left ventricular hemangioma who was referred to our hospital complaining of palpitation for one week. 24 h Holter revealed high episode of ventricular arrhythmia. Read More

    Modern Management of Nasal Hemangiomas.
    JAMA Facial Plast Surg 2017 May 11. Epub 2017 May 11.
    Hemangioma and Malformation Treatment Center, Charleston, South Carolina.
    Importance: Current treatment approaches for infantile hemangiomas of the nose include observation, pharmacologic agents, surgery, and/or laser therapy. Because of the known functional, social, and cosmetic effect of nasal deformities, obtaining the best possible result is critical. Optimal timing, type, duration, and extent of therapy remain unclear. Read More

    Scalp Infantile Hemangioma Complicated by Life-Threatening Bleeding.
    Pediatr Dermatol 2017 May 10. Epub 2017 May 10.
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    We report on an 8-month-old girl with an ulcerated occipital infantile hemangioma resulting in significant hemorrhage. The hemangioma responded rapidly to systemic propranolol and prednisolone, and we believe that describing her atypical clinical course would be helpful for others managing complicated scalp hemangiomas. Read More

    [Diagnosis and treatment of the tumors of the parotid region in Pediatrics: cohort].
    Cir Pediatr 2016 Oct 10;29(4):135-141. Epub 2016 Oct 10.
    Servicio de Cirugía Pediátrica. Hospital Italiano de Buenos Aires. Buenos Aires, Argentina.
    Introduction: Parotid tumors are rare in children and usually have multiple differential diagnoses that require different diagnostic and treatment methods.

    Material And Methods: Retrospective cohort study of all consecutive pediatric patients with parotid tumors that were treated in Pediatric Surgery Service of Hospital Italiano de Buenos Aires.

    Results: Twenty-two patients with parotid tumors were included and 72% (n=16) were female patients. Read More

    Temperature Instability in an Infant Treated with Propranolol for Infantile Hemangioma.
    J Pediatr Pharmacol Ther 2017 Mar-Apr;22(2):124-127
    Infantile hemangiomas are prevalent in the first few months of life and can be associated with risks of scarring, blindness, ulcerations, and airway obstruction depending on the location of lesions. Options for therapy include surgery, laser therapy, or medications. Propranolol is the only US Food and Drug Administration-approved medication option. Read More

    Capillary Hemangioma of the Tympanic Membrane and External Auditory Canal.
    J Craniofac Surg 2017 May;28(3):e231-e232
    Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
    Hemangiomas are very common tumors characterized by large numbers of vessels filled with blood. Capillary hemangioma is the most common type of hemangioma, whereas capillary hemangiomas of the tympanic membrane and external auditory canal are extremely rare vascular tumors. The authors present capillary hemangioma of the tympanic membrane and external auditory canal in a 54-year-old woman with right-sided aural fullness for 3 months. Read More

    Successful Treatment of Infantile Hemangiomas With Propranolol in Low-Birth-Weight Infants.
    J Craniofac Surg 2017 May;28(3):789-793
    *Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo †Department of Plastic and Reconstructive Surgery, Juntendo University Urayasu Hospital, Chiba ‡Department of Plastic and Reconstructive Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
    Background: Infantile hemangioma (IH) is a benign neoplasm that causes scarring and cosmetic problems after spontaneous regression. Therefore, aggressive treatments such as laser irradiation and corticosteroid have been used; however, recently, the effect of propranolol has been widely noticed. In this study, the authors applied propranolol to low-birth-weight infants with IHs and evaluated its effect. Read More

    Vascular Anomalies: A Pediatric Surgeon's Perspective.
    Indian J Pediatr 2017 May 3. Epub 2017 May 3.
    Department of Pediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
    Anomalies affecting the capillary and venous channels form the bulk of the spectrum of vascular anomalies. As per International Society for the Study of Vascular Anomalies (ISSVA) classification, these are referred to as hemangiomas and venous malformations respectively. The present article is a descriptive note of their management and outcomes. Read More

    Infantile hemangioma: Predicting proliferation by infrared thermography.
    Medicina (Kaunas) 2017 Apr 20. Epub 2017 Apr 20.
    Centre of Abdominal Surgery, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
    Background And Objective: Infantile hemangiomas (IHs) are benign lesions found in infants. Predicting the cosmetic outcome of these lesions is very difficult. Therefore, in this prospective study, we assessed whether using an infrared thermometer (IRT) to measure the surface temperature of IHs would help to predict their proliferative potential. Read More

    Effect of laser therapy on plasma expression of VEGF and bFGF in infants with cutaneous hemangioma.
    Oncol Lett 2017 Mar 25;13(3):1861-1865. Epub 2017 Jan 25.
    Department of Aesthetic Plastic and Burn Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
    The present study aimed to investigate the effect of laser therapy on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the plasma of infants diagnosed with cutaneous hemangioma, in order to identify biomarkers for assessing the clinical efficacy of laser therapy. In total, 109 infants with superficial abdominal hemangioma received laser treatment, of which 74 were diagnosed in the proliferation phase, 20 in the regression phase and 15 in the involution phase. In addition, 10 infants without cutaneous hemangioma were recruited as normal controls. Read More

    Efficacy and safety of oral propranolol for infantile hemangioma in Japan.
    Pediatr Int 2017 Apr 28. Epub 2017 Apr 28.
    Maruho Co., Ltd., Kyoto, Japan.
    Background: There have been few reports on the efficacy and safety of oral administration of propranolol at 3 mg/kg/day in Japanese infantile hemangioma (IH) patients.

    Methods: A multicenter, open-label phase III study was conducted to evaluate the efficacy and safety of oral propranolol solution in Japanese infants aged 35 to 150 days with proliferating IH. Thirty-two patients were enrolled in the study, received propranolol solution for 24 weeks at 3 mg/kg/day, and completed the study. Read More

    Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.
    J Histochem Cytochem 2017 May 1;65(5):285-294. Epub 2017 Feb 1.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education (H-FX, J-YZ, J-NW, J-GR, YC, F-QW, WZ, GC, Y-FZ, J-HZ), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
    Accumulating studies have revealed the hypoxic condition and its crucial role in the distinctive progression of infantile hemangioma (IH), the most common benign tumor in infancy. Activating transcription factor 4 (ATF4), an important gene mediating cellular adaptation to various stress signals, could confer a survival advantage for tumor cells under hypoxia and regulate tumor progression. However, the potential role of ATF4 in IH was still unknown. Read More

    Comparison of Renal Anastomosing Hemangiomas in End-Stage and Non-End-Stage Kidneys: A Meta-Analysis With a Report of 2 Cases.
    Int J Surg Pathol 2017 Apr 1:1066896917706025. Epub 2017 Apr 1.
    1 Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Background: Renal anastomosing hemangioma (RAH) is a very rare distinct entity composed of anastomosing sinusoidal (spleen-like) capillary-sized vessels lined by flat or hobnail endothelial cells. Most of the published cases of RAH occurred in the setting of end-stage renal disease (ESRD).

    Methods: We present 2 cases of RAH in ESRD along with a literature review. Read More

    Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial.
    JAMA Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea.
    Importance: There are limited data from randomized clinical trials comparing propranolol and steroid medication for treatment of infantile hemangioma (IH).

    Objective: To determine the efficacy and safety of propranolol compared with steroid as a first-line treatment for IH.

    Design, Setting, And Participants: This randomized clinical noninferiority trial tested the efficacy and safety of propranolol vs steroid treatment for IH at a single academic hospital. Read More

    The Role of Topical Timolol in the Treatment of Infantile Hemangiomas: A Systematic Review and Meta-analysis.
    Acta Derm Venereol 2017 Apr 19. Epub 2017 Apr 19.
    St. John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust,, Westminster Bridge Road, London SE1 7EH, United Kingdom.
    To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not be reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. Read More

    One-Stage Supramaximal Full-Thickness Wedge Resection of Vascular Lip Anomalies.
    J Oral Maxillofac Surg 2017 Mar 22. Epub 2017 Mar 22.
    Staff, Vascular Birthmark Institute of New York, Department of Otolaryngology, Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, New York, NY; Assistant Clinical Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. Read More

    Successful Treatment of a Residual, Thick, Infantile Hemangioma in a Darker Phototype Pediatric Patient Using the 755 nm Long-Pulsed Alexandrite Laser.
    Dermatol Surg 2017 Apr 11. Epub 2017 Apr 11.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York New York Laser & Skin Care, New York, New York.

    Debulking surgery for venous hemangioma arising from the epicardium: report of a case.
    World J Surg Oncol 2017 Apr 12;15(1):81. Epub 2017 Apr 12.
    Department of General Thoracic Surgery, Yamanashi Central Hospital, Yamanashi, Japan.
    Background: Cardiac hemangiomas are rare benign vascular tumors that can occur in any cardiac layer: endocardium, myocardium, or epicardium. Histologically, cardiac hemangiomas may be classified as capillary, cavernous, or arteriovenous; venous hemangiomas are extremely rare.

    Case Presentation: A 46-year-old man reported experiencing precordial discomfort. Read More

    Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment.
    Birth Defects Res 2017 Apr 12. Epub 2017 Apr 12.
    Department of Pediatrics, University of California San Diego, San Diego, California.
    Infantile hemangiomas (IHs) are the most common vascular tumors in infants, appearing in early infancy and ultimately regressing with time. Clinical presentation may vary, with a minority of lesions causing impairment of vital function (e.g. Read More

    Recent Advances in Orbital Tumors--A Review of Publications from 2014-2016.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):153-158
    Departments of Ophthalmic and Facial Plastic Surgery and Ocular Oncology, HORUS Specialty Eye Care, Bangalore, India.
    The aim of this review article is to provide an update of the current literature on orbital tumors. The authors conducted a PubMed literature search of English language articles published between January 2014 and December 2016 using the following search items: orbit, tumors, lacrimal gland, lymphoma, hemangioma, lymphangioma. The authors included reviews, original articles, case series, and case reports with relevant new information. Read More

    Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling.
    Int J Oncol 2017 May 3;50(5):1821-1831. Epub 2017 Apr 3.
    Department of Aesthetic, Plastic and Burn Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shangdong 250021, P.R. China.
    Hemangiomas are the most common vascular tumors that occur frequently in prematures and females. microRNA (miR)-130a is associated with the growth and invasion in many tumors, and its role in hemangiomas has not been addressed so far. The present study revealed that miR‑130a was overexpressed in infantile hemangioma tissues compared with matched tumor-adjacent tissues. Read More

    Features of sinonasal hemangioma: A retrospective study of 31 cases.
    Auris Nasus Larynx 2017 Apr 4. Epub 2017 Apr 4.
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.
    Objective: Although hemangiomas are common lesions of the head and neck, sinonasal hemangiomas are rare. The purpose of this study was to analyze the clinical features (sex, age, symptoms, and size and anatomical location of the lesion) and the histological findings of sinonasal hemangioma cases, to assess preoperative transarterial embolization, and to evaluate the outcome (recurrence or no recurrence) of endoscopic sinus surgery.

    Methods: Clinical records of 31 patients who underwent endoscopic sinus surgery for resection of sinonasal hemangioma between January 2010 and June 2015 were retrospectively reviewed. Read More

    Angiogenesis characteristics of infantile hemangioma and feasibility observation of transplantation model of human hemangioma on mice.
    Eur Rev Med Pharmacol Sci 2017 Mar;21(6):1276-1280
    Department of Burns and Plastic Surgery, Binzhou Medical University Hospital, Binzhou, China.
    Objective: To study pathogenic features of pediatric hemangiomas, we successfully established a model in mice, by transplanting human hemangioma tissues.

    Materials And Methods: The hemangioma from the leg of a two-month-old infant was dissected and sliced into several pieces. During a careful surgical procedure, the hemangioma tissues were individually transplanted into skin incisions in anesthetized mice. Read More

    Burden of Infantile Hemangioma on Family: An International Observational Cross-Sectional Study.
    Pediatr Dermatol 2017 May 6;34(3):295-302. Epub 2017 Apr 6.
    Pierre Fabre Dermatologie, Lavaur, France.
    Background/objectives: Infantile hemangioma (IH) is the most frequent benign tumor of infancy resulting from vascular proliferation. Data regarding the burden on families of children with IHs are limited. This study aimed to characterize IHs and provide a comprehensive evaluation of the burden of IHs on parents of children requiring systemic treatment in the United States and Europe. Read More

    The expression of renin-angiotensin-aldosterone axis components in infantile hemangioma tissue and the impact of propranolol treatment.
    Pediatr Res 2017 May 3. Epub 2017 May 3.
    Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
    BackgroundPropranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this nonselective beta antagonist downregulates renin-angiotensin-aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH.MethodsIH tissue and serum were collected from children with propranolol-treated or -untreated IH during surgery. Read More

    Transcriptional activation of hedgehog pathway components in aggressive hemangioma.
    Exp Dermatol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Pediatric Surgery, Dr. von Hauner Childrens' Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
    Infantile hemangioma is a vascular neoplasm and is one of the most common tumors diagnosed in young children. Although most hemangiomas are harmless and involute spontaneously, some show severe progression, leading to serious complications, such as high output cardiac failure, ulcerations, compression of the trachea or deprivation amblyopia, depending on their size and localization. However, the pathogenesis and cause of hemangioma are largely unknown to date. Read More

    Spectral Doppler Ultrasound for Predicting Long-Term Response to Topical Timolol in Children with Infantile Hemangioma.
    J Clin Ultrasound 2017 Mar 31. Epub 2017 Mar 31.
    Children's Hospital of Fudan University, Shanghai, 201102, China.
    Background: To assess the utility of color and spectral Doppler ultrasound at predicting infantile hemangioma (IH) response to timolol.

    Methods: Eighty-three children (0-6 months old) with IH were treated with topical 0.5% timolol maleate twice daily for 6 months. Read More

    Infantile hemangiopericytoma of the tongue-Efficacy of ex utero intrapartum treatment procedure and combined-modality therapy.
    Auris Nasus Larynx 2017 Mar 29. Epub 2017 Mar 29.
    Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
    Here we present an extremely rare case of giant infantile hemangiopericytoma (HPC) of the tongue diagnosed prenatally by fetal ultrasonography and MR imaging. Due to airway stenosis, the patient was delivered by the ex utero intrapartum treatment (EXIT) procedure at 36 weeks of pregnancy. Initial diagnosis was infantile hemangioma based on physical examination, diagnostic imaging and the high incidence of hemangioma. Read More

    SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA.
    Retin Cases Brief Rep 2017 Mar 29. Epub 2017 Mar 29.
    Retina and Vitreous Department, Clinica Privada de Ojos, Mar del Plata, Buenos Aires, Argentina.
    Purpose: To report a case showing a very rare association of chorioretinal coloboma and retinal capillary hemangioma in a previously healthy patient.

    Methods: Observational case report.

    Results: A 21-year-old woman presented at our clinic for vision screening. Read More

    Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway.
    Int J Mol Med 2017 Jan 20. Epub 2017 Jan 20.
    Department of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.
    Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. Read More

    Lymphocyte-rich capillary-cavernous hemangioma of the mitral valve: a case report and review of the literature.
    Cardiovasc Pathol 2017 May - Jun;28:59-63. Epub 2017 Mar 10.
    Cardiovascular Surgey Service, Marqués de Valdecilla University Hospital, Medical faculty, University of Cantabria and IDIVAL, Santander, Spain.
    Valvular hemangioma incidence is extremely low. In this report, we describe a 62-year-old man who presented with mild edema of the lower limbs. An echocardiogram revealed an incidental 1. Read More

    Nasal Lobular Capillary Hemangioma as a Complication after an Endoscopic Transsphenoidal Gonadotrophin-Producing Pituitary Adenoma Resection.
    J Neurol Surg Rep 2017 Jan;78(1):e59-e61
    Department of Neurosurgery, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.
    Background Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our institution. Read More

    Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review.
    Diagn Pathol 2017 Mar 20;12(1):28. Epub 2017 Mar 20.
    Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China.
    Background: Imaging and histology of clear-cell ependymoma and cerebellum-based hemangioblastoma are similar; distinguishing between them is a diagnostic challenge.

    Case Presentation: A 62-year-old Chinese woman presented with an intermittent headache of 8 years' duration. Computed tomography and magnetic resonance imaging revealed a mass in the cerebellum. Read More

    Infant skin maturation: Preliminary outcomes for color and biomechanical properties.
    Skin Res Technol 2017 Mar 16. Epub 2017 Mar 16.
    James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.
    Background: Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress. Read More

    Psoriasiform Diaper Rash Possibly Induced by Oral Propranolol in an 18-Month-Old Girl with Infantile Hemangioma.
    Case Rep Dermatol 2016 Sep-Dec;8(3):369-373. Epub 2016 Dec 22.
    Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
    Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. Read More

    A New Perspective for Infantile Hepatic Hemangioma in the Age of Propranolol: Experience at Baskent University.
    Exp Clin Transplant 2017 Mar;15(Suppl 2):74-78
    Department of Pediatric Oncology-Hematology, Baskent University Faculty of Medicine, Ankara, Turkey.
    Propranolol was first used in 2008 to treat hemangioma; its efficacy and safety have since changed the classical treatment indications. Infantile hepatic hemangioma presents as a spectrum of clinical conditions varying from simple asymptomatic lesions to lethal complications. Tufted hemangioma and Kaposiform hemangioendothelioma are congenital vascular tumors that lead to Kasabach-Merritt syndrome. Read More

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