5,074 results match your criteria Infantile Hemangioma
Pediatr Blood Cancer 2018 Jun 22:e27280. Epub 2018 Jun 22.
Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Background: There has been a paradigm shift from steroids to propranolol for the pharmacologic treatment of infantile hemangiomas (IH); however, the outcomes for ulcerated IH are not well studied. The purpose of this study was to compare the efficacy of steroids and propranolol specifically for ulcerated IH.
Methods: A retrospective review was conducted on patients with ulcerated IH treated with propranolol or steroids at a single tertiary care institution between 2007 and 2014. Read More
Oman J Ophthalmol 2018 May-Aug;11(2):166-168
Department of Ophthalmology, Dr. RML Hospital, New Delhi, India.
Von Hipple-Lindua (VHL) syndrome is an autosomal dominant neoplastic disorder in which multiple benign or malignant tumours and cysts develop in central nervous system and visceral organs. Retinal capillary hemangioma is the most frequent and often the earliest manifestation of VHL syndrome. We report a case with multisystemic involvement diagnosed as a case of multiple endocrine neoplasia (MEN) syndrome but the presence of multiple, unilateral peripheral and juxtapapillary retinal capillary hemangioma was able to clinche the definative diagnosis of VHL and thus helped in appropriate management of the patient. Read More
Plast Reconstr Surg 2018 Jun 12. Epub 2018 Jun 12.
Department of Pediatric Surgery in the Second Hospital of Hebei Medical University.
Background: Propranolol (PRO) is the first-line drug for infantile hemangioma treatment. However, its mechanism of action remains unclear. Nuclear factor-kappa B (NF-κB) is highly expressed in tumors, directly or indirectly promoting angiogenesis. Read More
An Bras Dermatol 2018 Jun;93(3):405-411
Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Infantile hemangioma can be linked to other organ malformations. In 1996, PHACE syndrome was first defined as the association of large and segmental infantile hemangioma, usually on the face, head, or cervical region, with malformations of the posterior fossa of the brain, arterial anomalies of the central nervous system, coarctation of the aorta, cardiac defects, and ocular abnormalities. Over 300 cases of PHACE syndrome have been reported, and it is cconsidered one of the most common neurocutaneous vascular disorders in childhood. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;32(11):875-877
Urology 2018 Jun 14. Epub 2018 Jun 14.
Department of Urology, Department of Urology, Graduate School of Medical and Dental, Kagoshima University, Kagoshima, Japan.
Infantile hemangiomas (IH) are the most common in the head and neck region. They can occur anywhere in the skin, however, urethral hemangiomas are very rare. We describe a case report of a three years old boy with extensive lesions of IH in the anterior urethra. Read More
Int J Womens Dermatol 2018 Mar 12;4(1):27-31. Epub 2017 Dec 12.
Ann & Robert H. Lurie Children's Hospital, Chicago, IL.
Background: Pediatric skin disorders can affect children's self-esteem, relationships with caregivers and peers, and performance in school and activities.
Objective: This review describes common pediatric congenital and acquired dermatologic disorders and the impact that these disorders can have on children's self-esteem.
Methods: A review of current, English-language literature was conducted with use of the PubMed database. Read More
BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.
Pediatrics, University of Massachusetts Medical School - Baystate, Springfield, MA, USA.
Rapidly involuting congenital haemangiomas (RICHs) are rare benign vascular tumours of infancy. They are generally asymptomatic, but can present with thrombocytopaenia and coagulopathy. Significant complications including life-threatening bleeding, high-output heart failure and liver failure, though rare, can occur. Read More
Retina 2018 07;38(7):e50-e52
Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Case Rep Otolaryngol 2018 8;2018:5973619. Epub 2018 May 8.
Division of Pathology, Children's Health, Dallas, TX, USA.
Lobular capillary hemangioma is a benign lesion of the skin and mucous membranes. Subcutaneous lobular capillary hemangioma presents as a deeper nodule. Lack of the characteristic surface changes of this subtype of lobular capillary hemangioma makes the clinical diagnosis challenging. Read More
Curr Opin Pediatr 2018 May 24. Epub 2018 May 24.
Section of Dermatology, Department of Medicine, West Virginia University, Morgantown, West Virginia, USA.
Purpose Of Review: Infantile hemangiomas are the most common vascular tumor of infancy. Treatment of infantile hemangiomas was revolutionized when propranolol, a nonselective β-blocker, was reported to be effective therapy. In this review, we highlight the lessons learned using propranolol to treat infantile hemangiomas. Read More
Pediatrics 2018 Jun;141(6)
University of Rennes, Rennes, France.
Objectives: The safety of oral propranolol for infantile hemangioma has not yet been studied at population level since the pediatric use marketing authorization was obtained in Europe.
Methods: A survey of a nationwide, claim-based observational cohort of children <3 years old, with at least 1 delivery of oral propranolol between July 2014 and June 2016, was performed by using the database of the French National Health Insurance system. Standardized morbidity ratios (SMRs) were calculated by using, from the same database, a representative random sample of nonexposed subjects. Read More
Exp Ther Med 2018 Jun 4;15(6):4677-4682. Epub 2018 Apr 4.
Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
The object of this study was to analyze the curative effect and safety of propranolol combined with prednisone in the treatment of infantile hemangiomas (IHs). Forty-four children with IHs on the head and face at the proliferative phase admitted to Jinan Center Hospital Affiliated to Shandong University were randomly divided into two groups. Children in group A took orally propranolol 2 mg/kg/day in three divided doses combined with prednisone 2 mg/kg/day in two divided doses in the first two weeks; children in group B took orally propranolol alone, and the dose was the same as that in group A. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Oct;31(20):1570-1574
Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
To study the clinical features and nasal image of children with nasal tumors.The samples of 40 cases of pediatric nasal tumors, which were diagnosed based on pathology, were collected. Clinical features, pathological histology and imaging characteristics were also summarized. Read More
World J Pediatr 2018 06 23;14(3):254-258. Epub 2018 May 23.
Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Background: The indication and extent of cardiac screening before oral propranolol therapy (OPT) in patients with infantile hemangioma (IH) has been challenged. In this study, we evaluated pre-OPT cardiac diagnostics in a pediatric IH cohort in our department.
Methods: Retrospective chart review of infants ≤ 12 months old with IH undergoing OPT. Read More
Laser Ther 2018 Mar;27(1):61-64
Department of pediatric surgery, Dokkyo Medical University Koshigaya Hospital.
Background And Aims: It is generally thought that bleeding from a hemangioma is difficult to stop. With development of the long pulse dye laser (LPDL), it has become possible to treat hemangioma with a large blood vessel diameter. Thus, it is effective in treating infantile hemangioma and pyogenic granuloma. Read More
Medicine (Baltimore) 2018 May;97(21):e10882
Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Background: Circular RNAs (circRNAs) have emerged as a novel class of widespread non-coding RNAs, and they play crucial roles in various biological processes. However, the characterization and function of circRNAs in infantile hemangioma (IH) remain elusive.
Methods: In this study, we used RNA-Seq and circRNA prediction to study and characterize the circRNAs in IH tissue and a matched normal skin control. Read More
Adv Clin Exp Med 2018 May 16. Epub 2018 May 16.
Department of Pediatric Surgery and Urology, Wroclaw Medical University, Poland.
Background: Propranolol has become the treatment of choice for infantile hemangiomas (IH). Neither the pathogenesis of IH nor the mechanism of action of propranolol on them are well understood. Possible explanations include the inhibition of angiogenesis by decreasing vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), induction of vascular endothelial cell apoptosis and vasoconstriction. Read More
Pediatr Dermatol 2018 May 23. Epub 2018 May 23.
Department of General Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC, Canada.
Background/objectives: Efficacy of topical sirolimus has recently been described in lymphatic anomalies but not in other types of vascular anomalies. To our knowledge, systemic absorption of topical sirolimus in these lesions has not yet been reported. The objective was to evaluate the efficacy, tolerance, and absorption of topical sirolimus 0. Read More
J Fr Ophtalmol 2018 May 17;41(5):e219-e224. Epub 2018 May 17.
National Institute of Ophthalmology, Tunisia University of Tunis El Manar, Faculty of Medicine of Tunis (FMT), 1053 Tunis, Tunisia.
Mol Med Rep 2018 May 14. Epub 2018 May 14.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University Xi'an, Shaanxi 710004, P.R. China.
The use of propranolol for the treatment of infantile hemangioma (IH) has been widely investigated in recent years. However, the underlying therapeutic mechanism of propranolol for the treatment of IH remains poorly understood. The aim of the present study was to investigate the expression of proteins regulated by cellular tumor antigen p53 (p53) in associated apoptosis pathways in IH endothelial cells (HemECs) treated with propranolol. Read More
Pediatr Dermatol 2018 May 15. Epub 2018 May 15.
Division of Dermatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Background/objectives: Infantile hemangiomas are the most common benign tumors of childhood. Although some children with periocular infantile hemangiomas do not require treatment, these lesions may result in amblyopia and visual impairment if not properly treated. We have attempted to characterize clinical features of periocular infantile hemangiomas that predict negative ocular outcomes and thus require prompt referral to an ophthalmologist and initiation of therapy. Read More
J Cutan Pathol 2018 May 15. Epub 2018 May 15.
Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
Background: We investigated 2 cases of deceptively bland cutaneous angiosarcoma (AS), which showed a uniform clinical presentation with a rapidly growing tumor on the nose. It remains unclear whether this was a primary cutaneous manifestation or a metastasis. Both tumors initially presented a high histologic overlap with a benign vascular tumor. Read More
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 May 16. Epub 2018 May 16.
Department of Ophthalmology for Children and Adults, Second Faculty of Medicine, Charles University, Prague and University Hospital Motol, Prague, Czech Republic.
Aim: Presentation of the efficacy of infrared laser for the treatment of retinal capillary hemangioma (RCH).
Methods: The treatment and follow-up of nine eyes (fourteen tumors of different sizes and localizations) in seven patients (five children) with RCH. Infrared diode laser (810 nm) was used for modified transpupillary thermotherapy (TTT) in long exposition mode and power between 200 and 1200 mW with a beam diameter of 2 mm (indirect ophthalmoscope, +28 D or +40 D lens) or 0. Read More
J Clin Pediatr Dent 2018 May 15. Epub 2018 May 15.
Pyogenic granuloma, also called lobular capillary hemangioma, is a benign vascular lesion of the skin and mucous membranes. While the majority of pyogenic granulomas in the oral cavity involve the gingiva, they also infrequently present at other sites including lips, oral mucosa, palate, and tongue. We report a case of a pyogenic granuloma of the tongue in a five-year old female patient. Read More
J Clin Pharmacol 2018 May 10. Epub 2018 May 10.
Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
This study aimed to characterize the population pharmacokinetics and exposure-response relationship of propranolol (Hemangiol Syrup for Pediatric) in infants with infantile hemangioma. Using nonlinear mixed-effects modeling with 63 pooled sets of plasma concentration-time data from 32 Japanese patients aged 35-150 days, we described the disposition of propranolol adequately by a 1-compartment model with first-order absorption. The estimated population mean apparent clearance and apparent central volume of distribution were 9. Read More
Clin Nucl Med 2018 Jul;43(7):499-501
Department of Radiology and Nuclear Medicine, University of Jordan, Amman, Jordan.
Abstracts: A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. Read More
Int J Surg Pathol 2018 May 1:1066896918773476. Epub 2018 May 1.
1 Department of Pathology and Laboratories, Fundación Santa Fe de Bogotá, Bogotá DC, Colombia.
Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. Read More
J Neurosurg Spine 2018 May 4:1-6. Epub 2018 May 4.
Departments of 1 Neurological Surgery and.
There is limited evidence to suggest that anterior approaches for the resection of ventral intramedullary lesions of the cervical spinal cord may result in superior neurological outcomes compared with those following more traditional posterior approaches. To the authors' knowledge, no report of an anterior approach to resect a ventral intramedullary capillary hemangioma exists in the literature. In the following paper, the case of a 75-year-old male who presented with progressive neck and left shoulder pain, weakness of the left hand, myelopathy, and gait imbalance is reported. Read More
Front Surg 2018 19;5:31. Epub 2018 Apr 19.
Gillies McIndoe Research Institute, Wellington, New Zealand.
We have recently demonstrated the expression of embryonic stem cell markers on the endothelium of infantile hemangioma, a functional hemogenic endothelium with the capacity for primitive erythropoiesis . Despite recent work characterizing stem cells within proliferating infantile hemangioma, the expression of STAT proteins, well documented for their roles in stem cell signaling, has not been investigated. 3,3-Diaminobenzidine and immunofluorescence immunohistochemical staining revealed expression of pSTAT1, pSTAT3 and pSTAT5 in proliferating infantile hemangioma samples with the strongest expression of pSTAT3. Read More
Arterioscler Thromb Vasc Biol 2018 Jun 3;38(6):1321-1332. Epub 2018 May 3.
From the Department of Molecular Pharmacology and Physiology (E.F.M., J.C., J.L., J.V., A.M., H.T.-J.)
Objective: Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth phase followed by a spontaneous involution, or triggered by propranolol treatment by poorly understood mechanisms. LIN28/let-7 axis plays a central role in the regulation of stem cell self-renewal and tumorigenesis. However, the role of LIN28B/let-7 signaling in IH pathogenesis has not yet been elucidated. Read More
Clin Imaging 2018 Jul - Aug;50:246-249. Epub 2018 Apr 13.
Stanford University School of Medicine, 300 Pasteur Drive, Room S-047, Stanford, CA 94305, United States.
Lobular capillary hemangiomas are acquired benign vascular neoplasms which typically affect the skin and mucous membranes. While these lesions commonly involve the head and neck, particularly the oral cavity, there are no reports in the literature of lobular capillary hemangioma arising from the mandible. The diagnosis of such a rare entity can therefore be challenging, especially as it may mimic more aggressive lesions, including malignancy. Read More
Plast Reconstr Surg 2018 May;141(5):709e-717e
Boston, Mass. From the Department of Plastic and Oral Surgery, Children's Hospital Boston, Harvard Medical School.
Background: Vascular anomalies currently are classified according to their clinical and histological characteristics. Recent advances in molecular genetics have enabled the identification of somatic mutations in most types of vascular anomalies. The purpose of this study was to collate information regarding the genetic basis of vascular anomalies. Read More
Biomed Res Int 2018 25;2018:5821369. Epub 2018 Feb 25.
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Background: The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs).
Methods: Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Read More
Quant Imaging Med Surg 2018 Mar;8(2):252-256
Radiology Department, Santobono Hospital, Napoli, Italy.
A very rare localization of infantile hemangioma (IH) is mesentery. It may manifest with intra-luminal or intra-peritoneal bleeding. Here there is the case of a 45-day-old infant, presenting with anemia and poor growth, subsequently referred to an uncommon hemangioma of the mesentery. Read More
J Cutan Med Surg 2018 Apr 1:1203475418770570. Epub 2018 Apr 1.
5 Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Read More
Cochrane Database Syst Rev 2018 04 18;4:CD006545. Epub 2018 Apr 18.
Paediatric Dermatology Department, Hospital San Jose-Fundacion Universitaria de Ciencias de la Salud, Carrera 19, No. 8A-32, Bogota, Colombia.
Background: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. Read More
Cancer Sci 2018 Jun 23;109(6):1981-1994. Epub 2018 May 23.
Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating activation of the vascular endothelial growth factor (VEGF) pathway, which is hyperactivated in IH. However, this treatment is reportedly ineffective for 10% of tumors, and 19% of patients relapse after propranolol treatment. Read More
Int J Mol Sci 2018 Apr 13;19(4). Epub 2018 Apr 13.
Department of Physiology, Faculty of Health Sciences, University of Pretoria, 9 Botshelo Road, Pretoria 0007, South Africa.
Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. Excessive neovessel formation is associated with various neoplasms such as infantile hemangiomas (IH). Read More
J Pediatr Gastroenterol Nutr 2018 Apr 12. Epub 2018 Apr 12.
Digestive Diseases & Nutrition Center, Women & Children's Hospital of Buffalo, Buffalo, NY.
Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Hemangiomas are benign vascular neoplasms which arise in early adulthood. Herein we present a 79-year-old woman with a hemangioma of the lower flank masquerading as a cutaneous manifestation of a systemic fungal infection upon initial histological analysis. Decreased elastin and collagen within the lesion likely accounted for the clumping and splaying of the capillaries into "hyphae-like" structures. Read More
Can J Ophthalmol 2018 Apr 22;53(2):e58-e60. Epub 2017 Sep 22.
Tulane University Department of Ophthalmology, New Orleans, LA. Electronic address:
J Craniofac Surg 2018 Apr 4. Epub 2018 Apr 4.
Institute of Plastic and Craniofacial Surgery, SOBRAPAR Hospital, Campinas, Brazil.
Background: Infantile hemangiomas (IH) are the most common benign vascular tumors in childhood. Approximately 10% to 15% of these tumors require drug or surgical intervention. There are many options for IH treatment, of which propranolol is currently considered the gold standard. Read More
Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207
3 Department of Pathology, University of Virginia, Charlottesville, Virginia.
This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors. Read More
Ann Plast Surg 2018 Apr;80(4 Suppl 4):S211-S213
From the Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Introduction: The life cycle of infantile hemangioma (IH) and secretion of follicle-stimulating hormone (FSH) are identical. We previously have shown that IH contains the FSH receptor (FSHR). The purpose of this study was to identify which cell type(s) in IH expresses FSHR. Read More
Rev Med Suisse 2018 Mar;14(600):670-675
Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.
Betablockers are used for decades in the treatment of cardiovascular diseases. Recently, the repurposing of the wide spectrum betablocker propranolol revolutionized the infantile hemangioma management. Besides, betablockers have been shown to significantly improve the prognosis of melanoma patients. Read More
World Neurosurg 2018 Jun 23;114:187-193. Epub 2018 Mar 23.
Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan.
Background: Hemangioblastomas usually occur in the cerebellum and are often a component of von Hippel-Lindau disease. Edema-like changes along the optic tract are commonly observed in association with tumors in the sellar and suprasellar regions, such as craniopharyngiomas and pituitary adenomas. Here, we describe a case of sporadic suprasellar hemangioblastoma with edema-like changes along the optic tract that completely resolved after surgery. Read More
Curr Probl Diagn Radiol 2018 Feb 14. Epub 2018 Feb 14.
Department of Radiology University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:
Hepatic small vessel hemangioma represents a distinct yet very rare pathologic entity of the liver. The entity has also been in the past referred to as adult capillary hemangioma of the liver and congenital noninvoluting hemangioma. Imaging findings are not definitive and biopsy or resection is ultimately necessary. Read More
Pediatr Radiol 2018 Mar 24. Epub 2018 Mar 24.
Department of Medical Imaging, Phoenix Children's Hospital, Phoenix, AZ, USA.
Infantile metastatic choriocarcinoma is a rare tumor of placental origin that can be observed with or without maternal metastases. A single cutaneous mass may be the only clinically observed sign. Reports of imaging findings are scarce given the extreme rarity of the tumor, and the disease can be rapidly fatal in the absence of prompt diagnosis. Read More