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AME Case Rep 2021 25;5:20. Epub 2021 Apr 25.

Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Infantile digital fibromatosis is a rare, benign fibrous tumor among infants usually limited to fingers and toes. Most cases present themselves with round eosinophilic inclusion bodies of different sizes, similar to erythrocyte in the parakarytoplasm. Although infantile digital fibromatosis had been observed with a tendency of spontaneous regression after a rapid phase of growth in some reports, the recurrence rate of early surgical intervention remains high. Read More

Dermatol Ther 2020 Sep 25:e14335. Epub 2020 Sep 25.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

J Dermatol 2020 Dec 18;47(12):e439-e440. Epub 2020 Sep 18.

Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Dermatol Ther 2020 11 6;33(6):e14012. Epub 2020 Aug 6.

Department of Orthopedics and Traumatology, Istanbul Medeniyet University, School of Medicine, Göztepe Education and Research Hospital, Istanbul, Turkey.

Cytopathology 2020 03 7;31(2):115-121. Epub 2020 Feb 7.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

Introduction: Fibroblastic/myofibroblastic tumors constitute 12% of all pediatric soft tissue tumors with the majority of them belonging to the benign and intermediate prognostic categories. They are often misdiagnosed owing to their variable clinical presentation and unusual microscopic features. The diagnosis, specially cytological diagnosis of benign and intermediate categories is difficult due to paucity of cellular component and increased amount of extracellular matrix as compared to malignant ones. Read More

Cytopathology 2019 09 1;30(5):565-566. Epub 2019 Jul 1.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

J Dtsch Dermatol Ges 2019 Apr 13;17(4):393-397. Epub 2019 Mar 13.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Fibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well-differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses. Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. Read More

Pediatr Dermatol 2018 Nov 31;35(6):e353-e356. Epub 2018 Aug 31.

Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

Terminal osseous dysplasia is a rare, X-linked syndrome, presumptively embryonic lethal in males, which has recently been described with highly characteristic skin findings. The presence of intracytoplasmic inclusion bodies in fibroblasts has been considered an exclusive finding of infantile digital fibromatosis. This is the first report documenting digital fibromas with intracytoplasmic inclusion bodies in a classic case of terminal osseous dysplasia. Read More

Eplasty 2018 7;18:e19. Epub 2018 May 7.

Division of Plastic Surgery.

Infantile digital fibromatosis is a rare benign childhood tumor, infrequently cited in the literature. Hallmarks include nodular growths exclusive to fingers and toes and the presence of eosinophilic cytoplasmic inclusions on histology. This article aims to exemplify diagnoses of infantile digital fibromatosis and possible treatment options. Read More

J Hand Surg Asian Pac Vol 2018 Jun;23(2):278-281

* Department of Plastic Surgery, Carmel Lady Davis Medical Center, Israel.

Infantile Digital Fibromatosis (IDF) is a rare benign lesion that can affect the fingers, often appearing at birth or early on in life. Treatment is controversial due to a high recurrence rate following surgical excision, and the tendency of the lesions to regress or resolve completely after the age of one year. Functional loss has rarely been described. Read More

G Ital Dermatol Venereol 2018 02;153(1):116-118

Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

J Dermatol 2017 May 14;44(5):549-551. Epub 2016 Nov 14.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Arch Pathol Lab Med 2016 Oct;140(10):1153-6

From the Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.

Infantile digital fibroma is a rare benign lesion that usually occurs during the first 2 years of life. It can be multiple, but it is usually a single lesion. If it grows large enough it can cause joint deformities or interfere with everyday activities. Read More

Pediatr Dermatol 2016 Jul 16;33(4):e252-3. Epub 2016 May 16.

Department of Dermatology, Acıbadem Hospital, Istanbul, Turkey.

Herein we present the case of a 16-month boy, clinically diagnosed with infantile digital fibromatosis, but 9 months after continued growth, the mass was excised and the histopathologic diagnosis was that of a benign nerve sheath myxoma. We present this case to emphasize that nerve sheath myxomas (also known as myxoid neurothekeoma) should be included in the differential diagnosis of dermal nodules in infants. Read More

Indian J Dermatol 2016 Mar-Apr;61(2):222-4

Department of Paediatrics, R.C.S.M. Government Medical College, Kolhapur, Maharashtra, India.

Int J Dermatol 2015 Nov 30;54(11):1214-25. Epub 2015 Jul 30.

Veterans Affairs Hospital & SUNY Downstate, Brooklyn, NY, USA.

There is little discussion of tumors arising in the digits in the dermatology literature. The patient with an undifferentiated mass of the finger is frequently encountered in the clinic, and variances in presentation of common and uncommon entities pose a challenge that may prompt further investigation for proper diagnosis and treatment. In this review, the authors illustrate the approach and work-up of an unknown digit mass of a 45-year-old female patient. Read More

J Dtsch Dermatol Ges 2014 Dec;12(12):1141-2

Department of Dermatology, University Medical Center Düsseldorf, Germany.

Ann Dermatol Venereol 2014 Mar 12;141(3):244-6. Epub 2013 Dec 12.

Service de dermatologie, faculté de médecine de Tunis, université de Tunis El-Manar, hôpital Habib-Thameur, 8, rue Ali Ben Ayed-Montfleury, 1008 Tunis, Tunisie.

Dermatol Online J 2014 Feb 18;20(2). Epub 2014 Feb 18.

Hospital Universitario Doctor Peset de Valencia.

Infantile digital fibromatosis is a rare benign fibro/myofibroblastic proliferation that almost only occurs on the fingers and toes. It is characterized by bright, round, intracytoplasmic, eosinophilic inclusions. We present a case of infantile digital fibromatosis in a 6-years-old child. Read More

Hand (N Y) 2013 Dec;8(4):473-8

Department of Dermatology, University Sant Joan de Déu Children's Hospital, Barcelona, Spain.

Histopathology 2014 Apr 12;64(5):752-5. Epub 2013 Dec 12.

Department of Pathology, Edinburgh Royal Infirmary, Edinburgh, UK.

Indian J Dermatol 2013 Mar;58(2):160

Department of Pediatrics, Yüzüncü Yil University, Van, Turkey.

A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. Read More

J Hand Surg Eur Vol 2014 Oct 11;39(8):888-9. Epub 2013 Apr 11.

Westmead Children's Hospital, NSW, Australia.

Int J Dermatol 2014 Jan 20;53(1):e16-8. Epub 2013 Jan 20.

Department of Pediatric Surgery, Sichuan University, West China Hospital, Chengdu, Sichuan Province, China E-mail:

Arch Dis Child 2013 Apr 15;98(4):308. Epub 2012 Dec 15.

Department of Pediatrics, Institute for Maternal and Child Health - IRCCS - Burlo Garofolo, Via dell'Istria 65, Trieste 34100, Italy.

Australas J Dermatol 2012 Nov 13;53(4):285-7. Epub 2011 Jun 13.

Department of Anaesthesia, Intensive Care and Dermatological Sciences, University of Milan, Foundation of IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Pace 9, Milan, Italy.

Infantile digital fibromatosis (IDF) is a rare tumour of infancy with a typical clinical presentation and characteristic histopathological findings. Despite an alarming appearance, IDF does not cause deep infiltration or metastasis. The traditional approach of surgical resection was recently challenged by increasing evidence of self regression in months or years. Read More

An Bras Dermatol 2012 May-Jun;87(3):493-4

Federal University of Sao Paulo, Brazil.

Infantile digital fibromatosis or Reye's tumor is a benign fibroproliferative tumor, the etiopathogenesis of which has yet to be fully clarified. It typically presents at birth or in the first year of life and is characterized by a firm, flesh colored or erythematous nodule or nodules located on the digits. These lesions tend to regress spontaneously. Read More

Arch Pediatr 2012 Mar 27;19(3):285-7. Epub 2012 Jan 27.

Service de pathologie, groupe hospitalier Pellegrin, CHU Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Infantile digital fibromatosis or inclusion body fibromatosis is a rare, benign fibroproliferative lesion with recurrent potential that occurs on the digits of infants. A highly characteristic morphologic finding is the presence of paranuclear inclusion within the tumoral cells. We report here a case occurring in an 8-month-old infant with 2 asynchronous lesions of the toes. Read More

Acta Cytol 2011 8;55(5):481-4. Epub 2011 Oct 8.

Department of Cytopathology, King Edward Memorial Hospital, Mumbai, India.

Background: Infantile digital fibromatosis (IDF) or inclusion body fibromatosis is a benign proliferation of fibroblastic and myofibroblastic cells. Its most common site is the digits of young children and it is named for the intracytoplasmic inclusions that are detected in lesional cells.

Case: A two and a half-year-old male child presented with a single flesh-colored nodule on the dorsal aspect of his right little toe since the sixth month of life. Read More

Chir Main 2011 Feb 12;30(1):62-5. Epub 2011 Jan 12.

Centro Regionale di Chirurgia della Mano, Ospedale San Paolo, Via Genova, Savona, Italy.

Infantile fibromatosis is an uncommon benign proliferation of myofibroblasts in the dermal tissue on the digits and toes with a marked tendency for recurrence. Inclusion bodies in the cytoplasm of neoplastic fibroblasts are a characteristic histologic feature of this condition. The tumor may often resolve spontaneously. Read More