211 results match your criteria Indoor Aeroallergens


An Overview of Rising CO₂ and Climatic Change on Aeroallergens and Allergic Diseases.

Authors:
Lewis H Ziska

Allergy Asthma Immunol Res 2020 Sep;12(5):771-782

Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

There are a number of implications of climate change in regard to human health. Among these, the role of rising carbon dioxide (CO₂) and temperature in aeroallergen exposure and associated changes in the start, duration and intensity of the pollen season, and associated consequences in aeroallergens and allergic disease are a primary concern. This review is intended to provide a synopsis of CO₂ and climate factors associated with likely changes in aeroallergen biology (indoor and outdoor), including changes in the demography of flowering plants, pollen seasonality, aeroallergen production, and potential biotic and abiotic interactions. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.771DOI Listing
September 2020

The Indoor Environment and Childhood Asthma.

Curr Allergy Asthma Rep 2020 Jun 16;20(9):43. Epub 2020 Jun 16.

Boston Children's Hospital, Division of Immunology, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Purpose Of Review: Sensitization and exposure to triggers in the indoor environment, including aeroallergens, indoor air pollution, and environmental tobacco smoke, have a significant role in asthma development and morbidity. This review discusses indoor environmental exposures and their effect on children with asthma as well as environmental interventions and their role in improving asthma morbidity.

Recent Findings: Recent research has emphasized the role of aeroallergen sensitization and exposure in asthma morbidity and the importance of the school indoor environment. Read More

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http://dx.doi.org/10.1007/s11882-020-00941-5DOI Listing

Airborne food and aeroallergens levels in healthcare settings. An unaccounted but potentially relevant source of exposure?

J Investig Allergol Clin Immunol 2020 Jun 5. Epub 2020 Jun 5.

Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Background And Objective: Exposure to airborne allergens of biological origin associates with the development and exacerbation of allergic asthma and rhinitis. Assessment of allergens exposure in healthcare facilities may contribute to monitor hygiene and survey specific allergens which may cause symptoms in sensitized subjects. Objective: To assess concentration of indoor and airborne food allergens across different healthcare settings. Read More

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http://dx.doi.org/10.18176/jiaci.0623DOI Listing

Identification of the major allergenic proteins from silkworm moth (Bombyx mori) involved in respiratory allergic diseases.

Allergol Immunopathol (Madr) 2020 Apr 10. Epub 2020 Apr 10.

Programa de Pós-graduação em Saúde da Criança e do Adolescente, Universidade Federal do Paraná, Brazil.

Introduction And Objectives: Moths are a significant source of indoor and outdoor aeroallergens. High prevalence of IgE-mediated sensitization was demonstrated in a group of patients with allergic respiratory diseases. There are no studies on adult stage of these moth species allergens involved in allergic respiratory reactions - the aim of this study. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.003DOI Listing

Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study.

Environ Sci Pollut Res Int 2020 Feb 19;27(5):5597-5605. Epub 2019 Dec 19.

Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.

Atopic asthma is characterized by the presence of sensitization to common aeroallergens, which tends to have a worse prognosis than non-atopic asthma. The objectives were to determine the prevalence of aeroallergens sensitization in the Lebanese pediatric asthmatic population and determine the relationship between allergens sensitization (indoor and outdoor) and age, area of residence and altitude. A sample, consisting of 919 asthmatic children (aged 1 to 18 years, from 2010 until 2017), underwent skin prick testing (SPT) with 21 common allergens: 5 grasses (cocksfoot, sweet vernal-grass, rye-grass, meadow grass, timothy), Parietaria, olive, Dermatophagoides pteronyssinus and Dermatophagoides farina (DP-DF), dog and cat dander, Alternaria longipens, Aspergillus fumigatus and nidulans, Cupressaceae, pine, German cockroach, and 4 cereals (oat, wheat, barley, maize). Read More

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http://dx.doi.org/10.1007/s11356-019-07234-zDOI Listing
February 2020

Effects of indoor particulate matter exposure on daily asthma control.

Ann Allergy Asthma Immunol 2019 10 26;123(4):375-380.e3. Epub 2019 Jul 26.

National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Medicine, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom. Electronic address:

Background: Household dust often contains aeroallergens, such as the house dust mite antigen Der p 1. It has been proposed that overnight exposure to particulate matter from bedding and other sources may be an important driver of atopic asthma. Whether variability in overnight particulate matter exposure is a significant determinant of asthma control is unknown. Read More

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http://dx.doi.org/10.1016/j.anai.2019.07.020DOI Listing
October 2019
2 Reads

Human glutathione-S-transferase pi potentiates the cysteine-protease activity of the Der p 1 allergen from house dust mite through a cysteine redox mechanism.

Redox Biol 2019 09 11;26:101256. Epub 2019 Jun 11.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. Electronic address:

Environmental proteases have been widely associated to the pathogenesis of allergic disorders. Der p 1, a cysteine-protease from house dust mite (HDM) Dermatophagoides pteronyssinus, constitutes one of the most clinically relevant indoor aeroallergens worldwide. Der p 1 protease activity depends on the redox status of its catalytic cysteine residue, which has to be in the reduced state to be active. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597738PMC
September 2019
12 Reads

Impact of weather and climate change with indoor and outdoor air quality in asthma: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee.

J Allergy Clin Immunol 2019 05 28;143(5):1702-1710. Epub 2019 Feb 28.

University of California Los Angeles, David Geffen School of Medicine and California NanoSystems Institute, Los Angeles, Calif.

Weather and climate change are constant and ever-changing processes that affect allergy and asthma. The purpose of this report is to provide information since the last climate change review with a focus on asthmatic disease. PubMed and Internet searches for topics included climate and weather change, air pollution, particulates, greenhouse gasses, traffic, insect habitat, and mitigation in addition to references contributed by the individual authors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193028
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http://dx.doi.org/10.1016/j.jaci.2019.02.018DOI Listing
May 2019
35 Reads

Perceived Versus Actual Aeroallergen Sensitization in Urban Children.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1591-1598.e4. Epub 2019 Jan 14.

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Background: Individuals often report allergy to specific aeroallergens, but allergy testing can reveal disparate sensitization.

Objective: To characterize the agreement between perceived and actual sensitization to individual aeroallergens in an urban pediatric population.

Methods: A total of 253 children were enrolled from pediatric clinics in New York, NY. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511290PMC
January 2019
9 Reads

Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran.

Iran J Immunol 2018 Dec;15(4):294-301

Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz.

Background: The frequency of sensitization to respiratory allergens is different in various geographical regions.

Objective: To determine the level of specific IgE to respiratory allergens in patients with atopy in Ahvaz, Iran.

Methods: In this retrospective cross-sectional study, the total and specific IgE data were recorded for 408 patients with allergic rhinitis and asthma referred to allergy diagnostic laboratory in Ahvaz from 2014 to 2017. Read More

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http://iji.sums.ac.ir/article_40593.html
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http://dx.doi.org/10.22034/IJI.2018.39398DOI Listing
December 2018
41 Reads
0.707 Impact Factor

Aeroallergen Exposure and Spread in the Modern Era.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1835-1842

Division of Allergy & Immunology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio. Electronic address:

Since the initial discovery of aeroallergens in the 20th century, our understanding of their properties including sources and factors influencing their spread continues to expand. Both habits of daily living and the presence of environmental factors such as exposure to animals or pollution can influence susceptibility to atopic disease. Because relevant allergens may vary in individuals and communities, it is necessary to understand the physical properties of environmental aeroallergens that are associated with clinical disease to explain symptoms and to implement successful integrated interventions. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.08.014DOI Listing
November 2019

Aeroallergens Exacerbate Infection.

J Immunol 2018 12 22;201(11):3352-3361. Epub 2018 Oct 22.

Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267; and

Allergens such as house dust mites (HDM) and papain induce strong Th2 responses, including elevated IL-4, IL-5, and IL-13 and marked eosinophilia in the airways. is a dimorphic fungal pathogen that induces a strong Th1 response marked by IFN-γ and TNF-α production, leading to rapid clearance in nonimmunocompromised hosts. Th1 responses are generally dominant and overwhelm the Th2 response when stimuli for both are present, although there are instances when Th2 stimuli downregulate a Th1 response. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1800644
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1800644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246782PMC
December 2018
23 Reads

Skin Prick Test Reactivity to Common Aeroallergens among Allergic Rhinitis Patients.

J Coll Physicians Surg Pak 2018 Oct;28(10):766-771

Department of Computer Science, College of Computer Science and Information Technology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objective: To identify the common aeroallergens causing allergy symptoms among the allergic rhinitis patients.

Study Design: Cross-sectional study.

Place And Duration Of Study: Department of Immunology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January to July 2016. Read More

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http://dx.doi.org/3018DOI Listing
October 2018
35 Reads

Aeroallergen sensitization and associated comorbid diseases of an adult Filipino population with allergic rhinitis.

Asia Pac Allergy 2018 Jul 17;8(3):e25. Epub 2018 Jul 17.

Department of Otolaryngology-Head & Neck Surgery, St. Luke's Medical Center-Quezon City, Quezon City 1112, the Philippines.

Background: There is a large global variation in sensitization patterns to aeroallergens due to differences in climate, urbanization, and lifestyle. Knowledge of the most common inhalant allergens is important for appropriate prevention and management of allergic rhinitis (AR).

Objective: This study aims to provide data on aeroallergen sensitization patterns and associated comorbid diseases of adult Filipinos with AR. Read More

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http://dx.doi.org/10.5415/apallergy.2018.8.e25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073179PMC
July 2018
13 Reads

High burden of atopy in immigrant families in substandard apartments in Sweden - on the contribution of bad housing to poor health in vulnerable populations.

World Allergy Organ J 2018 15;11(1). Epub 2018 May 15.

1Division of Occupational and Environmental Medicine, Medical Faculty, Lund University, 22185 Lund, Sweden.

Background: Atopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowding etc. Read More

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http://dx.doi.org/10.1186/s40413-018-0188-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952630PMC
May 2018
18 Reads

Airborne protein concentration: a key metric for type 1 allergy risk assessment-in home measurement challenges and considerations.

Clin Transl Allergy 2018 26;8:10. Epub 2018 Mar 26.

SEAC Unilever Colworth, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ UK.

Background: Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the likelihood that sensitisation will be induced. The main objective of this study was to determine whether airborne concentrations of selected common aeroallergens could be quantified in the air of homes using easily deployable, commercially available equipment and analytical methods, at low levels relevant to risk assessment of the potential to develop respiratory allergies. Additionally, air and dust sampling were compared and the influence of factors such as different filter types on allergen quantification explored. Read More

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http://dx.doi.org/10.1186/s13601-018-0196-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868064PMC
March 2018
11 Reads

External exposome and allergic respiratory and skin diseases.

J Allergy Clin Immunol 2018 03;141(3):846-857

Sorbonne Université, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Saint-Antoine Medical School, Paris, France. Electronic address:

Allergies are complex diseases that result from interactions between multiple genetic and environmental factors. However, the increase in allergies observed in the past decades is explained exclusively by environmental changes occurring in the same period. Presently, the exposome, the totality of specific and nonspecific external environmental exposures (external exposome) to which a subject is exposed from preconception onward and their consequences at the organ and cell levels (internal exposome), is being considered to explain the inception, development, and exacerbations of allergic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183014
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http://dx.doi.org/10.1016/j.jaci.2018.01.016DOI Listing
March 2018
20 Reads

Respiratory comorbidity in South African children with atopic dermatitis.

S Afr Med J 2017 Sep 22;107(10):904-909. Epub 2017 Sep 22.

Division of Allergology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens.

Objectives: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD.

Methods: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA. Read More

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http://dx.doi.org/10.7196/SAMJ.2017.v107i10.12418DOI Listing
September 2017
60 Reads

Allergy and immunology in Africa: Challenges and unmet needs.

J Allergy Clin Immunol 2017 Nov 27;140(5):1240-1243. Epub 2017 Sep 27.

Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.

The tremendous increase in allergy in the African continent cannot simply be explained by the change in public hygiene. There are many "prehygiene" communities with sewage-contaminated water supplies, helminth infestations, bare footedness, and poor housing, and still there is a high prevalence of allergic disease. Africans can be exposed to many risk factors facilitating severe asthma and wheezing, including airborne viruses, smoke, indoor dampness, cockroaches, and poor access to health care. Read More

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http://dx.doi.org/10.1016/j.jaci.2017.09.004DOI Listing
November 2017
25 Reads

Determination of the Most Common Indoor and Outdoor Allergens in 602 Patients with Allergic Symptoms Using Specific IgE Local Panel.

Iran J Allergy Asthma Immunol 2017 Aug;16(4):298-306

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Aeroallergens play an important role in developing allergic diseases. The aim of this study was to determine the outdoor and indoor sensitization using a specific regional panel of aeroallergens in allergic patients. All patients with allergic symptoms referred to Immunology, Asthma and Allergy Research Institute (IAARI) in Tehran, Iran from December 2010 to July 2013 entered this cross sectional study. Read More

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August 2017
18 Reads

Indoor visible mold and mold odor are associated with new-onset childhood wheeze in a dose-dependent manner.

Indoor Air 2018 Jan 11;28(1):6-15. Epub 2017 Sep 11.

He Kainga Oranga/Housing and Health Research Group, Department of Public Health, University of Otago, Wellington, New Zealand.

Evidence is accumulating that indoor dampness and mold are associated with the development of asthma. The underlying mechanisms remain unknown. New Zealand has high rates of both asthma and indoor mold and is ideally placed to investigate this. Read More

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http://dx.doi.org/10.1111/ina.12413DOI Listing
January 2018
54 Reads

Sensitization to Common Aeroallergens in Asthmatic Children in the Eastern Region of Saudi Arabia.

Authors:
Suzan A AlKhater

Saudi J Med Med Sci 2017 May-Aug;5(2):136-141. Epub 2017 Apr 20.

Department of Pediatrics, College of Medicine, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia.

Background: Allergic disorders, particularly bronchial asthma, are one of the most common chronic childhood diseases. Bronchial asthma is more prevalent among children of the Eastern Province of Saudi Arabia compared with the other provinces. Environmental factors play major roles in the disease pathogenesis in genetically predisposed hosts. Read More

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http://dx.doi.org/10.4103/1658-631X.204876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298380PMC
April 2017
6 Reads

Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.

Clin Mol Allergy 2017 3;15. Epub 2017 Mar 3.

Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.

Background: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.

Methods: Three-hundred and four children (median age 13. Read More

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http://dx.doi.org/10.1186/s12948-017-0061-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335719PMC
March 2017
22 Reads

Prevalence of allergen sensitization in 1000 adults in Saskatchewan.

Allergy Asthma Clin Immunol 2017 8;13. Epub 2017 Feb 8.

Department of Internal Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.

Background: The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More importantly we aimed to obtain a regional statistic of sensitization to common allergens given Saskatchewan's dry climate. Read More

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http://aacijournal.biomedcentral.com/articles/10.1186/s13223
Publisher Site
http://dx.doi.org/10.1186/s13223-017-0181-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299636PMC
February 2017
15 Reads

Association Between Allergen Exposure in Inner-City Schools and Asthma Morbidity Among Students.

JAMA Pediatr 2017 01;171(1):31-38

Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts.

Importance: Home aeroallergen exposure is associated with increased asthma morbidity in children, yet little is known about the contribution of school aeroallergen exposures to such morbidity.

Objective: To evaluate the effect of school-specific aeroallergen exposures on asthma morbidity among students, adjusting for home exposures.

Design, Setting, And Participants: The School Inner-City Asthma Study was a prospective cohort study evaluating 284 students aged 4 to 13 years with asthma who were enrolled from 37 inner-city elementary schools in the northeastern United States between March 1, 2008, and August 31, 2013. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2016.2543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349325PMC
January 2017
37 Reads

Does Spore Count Matter in Fungal Allergy?: The Role of Allergenic Fungal Species.

Allergy Asthma Immunol Res 2016 Sep;8(5):404-11

Department of Life Science, Tunghai University, Taichung, Taiwan.

Purpose: Fungi have been known to be important aeroallergens for hundreds of years. Most studies have focused on total fungal concentration; however, the concentration of specific allergenic fungi may be more important on an individual basis.

Methods: Ten fungal allergic patients and 2 non-fungal allergic patients were enrolled. Read More

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http://dx.doi.org/10.4168/aair.2016.8.5.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921694PMC
September 2016
47 Reads
3 Citations
3.084 Impact Factor

Sensitisation to mites and other animal-derived home aeroallergens in children and its concordance as a measure of covariation of sensitisation.

Authors:
L Moral T Toral

Allergol Immunopathol (Madr) 2016 Sep-Oct;44(5):427-32. Epub 2016 May 27.

Pediatric Allergy and Respiratory Unit, Hospital General Universitario de Alicante, Alicante, Spain.

Background: Sensitisation to home aeroallergens (mites, furry animals and cockroaches) is predominant in patients in our and other areas. Covariation of sensitisation (CS) to these allergens could be due to cross-reactivity or parallel sensitisation.

Methods: Skin prick tests were performed to common and second-line home aeroallergens, shrimp and tropomyosin in 253 paediatric patients seen in our Unit due to chronic respiratory symptoms. Read More

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http://dx.doi.org/10.1016/j.aller.2016.02.004DOI Listing
January 2017
11 Reads

Increase in pollen sensitization in Swedish adults and protective effect of keeping animals in childhood.

Clin Exp Allergy 2016 10 6;46(10):1328-36. Epub 2016 Jun 6.

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Gothenburg University, Göteborg, Sweden.

Background: To date, most studies of the 'allergy epidemic' have been based on self-reported data. There is still limited knowledge on time trends in allergic sensitization, especially among adults.

Objective: To study allergic sensitization, its risk factors and time trends in prevalence. Read More

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http://dx.doi.org/10.1111/cea.12757DOI Listing
October 2016
9 Reads

Asthma in Urban Children: Epidemiology, Environmental Risk Factors, and the Public Health Domain.

Curr Allergy Asthma Rep 2016 Apr;16(4):33

Division of Allergy and Immunology, Children's National Health System, George Washington University School of Medicine and Health Sciences, 111 Michigan Avenue, NW, Washington, DC, 20010, USA.

Asthma is the most commonly reported chronic condition of childhood in developed countries, with 6.5 million children affected in the USA. A disparate burden of childhood asthma is seen among socioeconomically disadvantaged youth, often concentrated in urban areas with high poverty rates. Read More

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http://dx.doi.org/10.1007/s11882-016-0609-6DOI Listing
April 2016
17 Reads

A review on emerging frontiers of house dust mite and cockroach allergy research.

Authors:
S Patel B R Meher

Allergol Immunopathol (Madr) 2016 Nov - Dec;44(6):580-593. Epub 2016 Mar 16.

Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.

Currently, mankind is afflicted with diversified health issues, allergies being a common, yet little understood malady. Allergies, the outcome of a baffled immune system encompasses myriad allergens and causes an array of health consequences, ranging from transient to recurrent and mild to fatal. Indoor allergy is a serious hypersensitivity in genetically-predisposed people, triggered by ingestion, inhalation or mere contact of allergens, of which mite and cockroaches are one of the most-represented constituents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010546160000
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http://dx.doi.org/10.1016/j.aller.2015.11.001DOI Listing
January 2017
11 Reads

The importance of mold sensitivity in nonallergic rhinitis patients.

Int Forum Allergy Rhinol 2016 07 16;6(7):716-21. Epub 2016 Feb 16.

Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Allergy, Istanbul University, Istanbul, Turkey.

Background: In recent studies, local specific immunoglobulin E (sIgE) production against allergens in nasal mucosa and a positive response to a nasal allergen provocation test (NAPT) have been demonstrated in some patients initially diagnosed as nonallergic rhinitis (NAR) or idiopathic rhinitis (IR). The aim of this study was to evaluate the presence of local allergic rhinitis (LAR) in patients who experience rhinitis symptoms in indoor and outdoor moldy conditions and to investigate the role of the NAPT in diagnosis.

Methods: A total of 40 NAR patients with a history of persistent rhinitis and who had negative skin-prick tests (SPTs) and serum sIgE levels to common aeroallergens, as well as 20 healthy subjects were included in the study. Read More

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http://dx.doi.org/10.1002/alr.21731DOI Listing
July 2016
16 Reads

Alternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy.

Environ Int 2016 Apr-May;89-90:71-80. Epub 2016 Jan 28.

Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy and Laboratory of Parasitology and Allergy, Lascaray Research Centre, University of the Basque Country, Vitoria, Spain. Electronic address:

Alternaria alternata spores are considered a well-known biological contaminant and a very common potent aeroallergen source that is found in environmental samples. The most intense exposure to A. alternata allergens is likely to occur outdoors; however, Alternaria and other allergenic fungi can colonize in indoor environments and thereby increase the fungal aeroallergen exposure levels. Read More

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http://dx.doi.org/10.1016/j.envint.2016.01.003DOI Listing
November 2016
15 Reads

Aeroallergens, atopy and allergic rhinitis in the Middle East.

Authors:
L Goronfolah

Eur Ann Allergy Clin Immunol 2016 Jan;48(1):5-21

Department of Pediatrics - Allergy & Immunology, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia. E-mail:

The literature on the nature and prevalence of indoor and/or outdoor aeroallergens, atopy and symptoms of rhinitis and asthma in the Middle East region (defined here as Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Qatar, Kingdom of Saudi Arabia - KSA, Syria, United Arab Emirates and Yemen) was reviewed. Although documentation was poor in all countries other than Iran and the KSA, a wide range of "global" and "local" aeroallergens (grass, weed and tree pollens, fungal spores, insect allergens, dander, and house dust mites) has been observed across the region. The prevalence of current self-reported or parent-reported symptoms of rhinitis ranged from 9% to 38%. Read More

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January 2016
12 Reads

Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial.

Trials 2016 Jan 8;17:15. Epub 2016 Jan 8.

Portsmouth Hospitals NHS Trust, Portsmouth, UK.

Background: Asthma affects more than 5 million patients in the United Kingdom. Nearly 500,000 of these patients have severe asthma with severe symptoms and frequent exacerbations that are inadequately controlled with available treatments. The burden of severe asthma on the NHS is enormous, accounting for 80 % of the total asthma cost (£1 billion), with frequent exacerbations and expensive medications generating much of this cost. Read More

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https://www.researchgate.net/profile/Anoop_Chauhan2/publicat
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http://trialsjournal.biomedcentral.com/articles/10.1186/s130
Publisher Site
http://dx.doi.org/10.1186/s13063-015-1134-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705626PMC
January 2016
53 Reads

The TLR4-associated phospholipase D1 activation is crucial for Der f 2-induced IL-13 production.

Allergy 2015 Dec 28;70(12):1569-79. Epub 2015 Sep 28.

Biomedical Research Institute and Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea.

Background: House dust mites (HDMs) are the most important source of indoor aeroallergens that contribute to the rising incidence of allergic diseases such as allergic asthma. The major HDM, Der f 2, induces inflammatory cytokine expression. Little is known about the signaling pathway involved. Read More

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http://doi.wiley.com/10.1111/all.12764
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http://dx.doi.org/10.1111/all.12764DOI Listing
December 2015
9 Reads

Environmental aeroallergens and allergic rhino-conjunctivitis.

Curr Opin Allergy Clin Immunol 2015 Oct;15(5):476-81

School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia.

Purpose Of Review: The rising prevalence of allergy and of allergic rhino-conjunctivitis is associated with changes in modern lifestyle. The current period of rapid development and consequent urbanization and migration, coupled with changes in climate, is facilitating a growth in rates of allergy.

Recent Findings: Alterations to indoor and outdoor environments resulting from urbanization, industrialization, and climate change have significant implications for the prevalence and management of allergic rhino-conjunctivitis. Read More

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http://pdfs.journals.lww.com/co-allergy/9000/00000/Environme
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http://dx.doi.org/10.1097/ACI.0000000000000205DOI Listing
October 2015
8 Reads

Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States.

Am J Respir Crit Care Med 2015 Dec;192(11):1287-97

2 Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; and.

Rationale: Inhaled endotoxin induces airway inflammation and is an established risk factor for asthma. The 2005-2006 National Health and Nutrition Examination Survey included measures of endotoxin and allergens in homes as well as specific IgE to inhalant allergens.

Objectives: To understand the relationships between endotoxin exposure, asthma outcomes, and sensitization status for 15 aeroallergens in a nationally representative sample. Read More

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http://dx.doi.org/10.1164/rccm.201502-0251OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731700PMC
December 2015
28 Reads

Skin Prick Test Reactivity to Aeroallergens among Egyptian Patients with Isolated Allergic Conjunctival Disease.

Egypt J Immunol 2015 Jun;22(2):41-47

Department of Community Environmental & Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Allergic conjunctival disease (ACD) is a type of ocular allergy, which includes seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), and vernal keratoconjunctivitis (VKC). Little is known about the pattern of sensitization or prevalent aeroallergens among patients with isolated ACD in Egypt We aimed to evaluate the prevalence of skin prick test positivity to common aeroallergens among Egyptian patients with isolated allergic conjunctival disease. The study included 75 patients with isolated ACD recruited from a tertiary Egyptian outpatient clinic. Read More

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June 2015
14 Reads

Ionizer assisted air filtration for collection of submicron and ultrafine particles-evaluation of long-term performance and influencing factors.

Environ Sci Technol 2015 Jun 15;49(11):6891-8. Epub 2015 May 15.

†Department of Energy and Environment, Chalmers University of Technology, Göteborg, Sweden.

Previous research has demonstrated that unipolar ionization can enhance the filter performance to collect airborne particles, aeroallergens, and airborne microorganisms, without affecting the filter pressure drop. However, there is a lack of research on the long-term system performance as well as the influence of environmental and operational parameters. In this paper, both field and laboratory tests were carried out to evaluate the long-term particle collection efficiency of a synthetic filter of class M6 with and without ionization. Read More

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http://dx.doi.org/10.1021/acs.est.5b00974DOI Listing
June 2015
13 Reads

House dust mite-specific immunoglobulin E and longitudinal exhaled nitric oxide measurements in children with atopic asthma.

Korean J Pediatr 2015 Mar 20;58(3):89-95. Epub 2015 Mar 20.

Department of Pediatrics, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea.

Purpose: House dust mite (HDM) has been suggested to be the most important aeroallergen responsible for atopic asthma in Korea. We aimed to investigate that specific IgE antibodies to HDM and other common indoor aeroallergens contribute differently to total serum IgE and show different relationships with longitudinal fractional exhaled nitric oxide (FeNO) measurements in Korean atopic asthmatic patients.

Methods: A total of 193 children aged 8 to 16 years with intermittent or mild persistent atopic asthma were recruited. Read More

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http://dx.doi.org/10.3345/kjp.2015.58.3.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388976PMC
March 2015
10 Reads

Common aeroallergens in patients with asthma and allergic rhinitis living in southwestern part of Iran: based on skin prick test reactivity.

Iran J Allergy Asthma Immunol 2015 Apr;14(2):133-8

The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

Aeroallergens continue to have a key role in the pathogenesis of asthma and allergic diseases and have recently received increased attention in medical research throughout the world. The prevalence of aeroallergens vary in different regions, depending on the type of climate. The aim of the present study was to determine prevalence of the sensitivity to aeroallergens among patients with asthma and allergic rhinitis (AR), based on skin prick test (SPT) reactivity in the province of Bushehr, Iran. Read More

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http://www.sid.ir/en/VEWSSID/J_pdf/94320150204.pdf
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April 2015
26 Reads

Bedroom air quality and vacuuming frequency are associated with repeat child asthma hospital admissions.

J Asthma 2015 Sep 27;52(7):727-31. Epub 2015 Feb 27.

a School of Public Health, La Trobe University , Bundoora , Australia .

Objective: Indoor environment factors have been associated with risk of asthma exacerbations in children but little is known about their role on asthma hospital readmissions. As children in Western societies continually spend more time indoors, understanding the influence of these factors on asthma exacerbation is important. We examined the role of indoor environmental and lifestyle characteristics on child asthma readmissions. Read More

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http://dx.doi.org/10.3109/02770903.2014.1001904DOI Listing
September 2015
21 Reads

Measurement of aeroallergens from furnace filters.

Ann Allergy Asthma Immunol 2015 Mar 18;114(3):221-5. Epub 2014 Nov 18.

The Children's Mercy Hospital, Kansas City, Missouri.

Background: Exposure assessment is an important component of allergic disease diagnosis and management. Analysis for allergen content in vacuumed dust has been used traditionally.

Objective: To study allergen levels of dust taken from high-efficiency furnace filters in Midwestern homes. Read More

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http://dx.doi.org/10.1016/j.anai.2014.10.015DOI Listing
March 2015
38 Reads

Allergic fungal airway disease: pathophysiologic and diagnostic considerations.

Curr Opin Pulm Med 2015 Jan;21(1):39-47

aInstitute for Lung Health, Department of Infection Immunity and Inflammation, University of Leicester bDepartment of Allergy and Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.

Purpose Of Review: Fungal spores are ubiquitously present in indoor and outdoor air. A number can act as aeroallergens in Immunoglobulin E (IgE)-sensitized individuals and some thermotolerant fungi germinate in the lung where they can cause a combined allergic and infective stimulus leading to a number of clinical presentations characterized by evidence of lung damage. We discuss which biomarkers are useful in helping to guide diagnosis, prognosis and treatment of allergic fungal airway disease (AFAD). Read More

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http://pdfs.journals.lww.com/co-pulmonarymedicine/2015/01000
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http://dx.doi.org/10.1097/MCP.0000000000000129DOI Listing
January 2015
46 Reads

Identification of aero-allergen sensitization in children seeking treatment for bronchial asthma at a tertiary care hospital for children in Sri Lanka.

Ceylon Med J 2014 Sep;59(3):89-93

Department of Paediatrics, Faculty of Medicine, University of Colombo, Sri Lanka.

Objectives: Despite a significant rise in asthma globally as well as in Sri Lanka, data regarding allergen sensitization patterns and other risk factors for asthma are not available. Therefore, we set out to determine the allergen sensitization patterns in children with asthma in Sri Lanka.

Methods: Skin prick testing for common indoor aeroallergens (cockroach, cat, dog, house dust mite, moulds) were carried out in 156 children with bronchial asthma at Lady Ridgeway Hospital for Children. Read More

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http://dx.doi.org/10.4038/cmj.v59i3.7469DOI Listing
September 2014
8 Reads

Aeroallergen sensitivity in Hawai'i: association with asthma and increased prevalence of sensitivity to indoor allergens since 1966.

Hawaii J Med Public Health 2014 Sep;73(9 Suppl 1):9-12

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI.

Asthma and allergic diseases have increased globally. Earlier studies suggest a history of excess asthma morbidity and mortality in Hawai'i, with high prevalence of sensitization to outdoor aeroallergens among atopic children. This study was undertaken to test the hypotheses that specific allergens are more associated with asthma, and that sensitivity to common aeroallergens has increased in Hawai'i since 1966. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175945PMC
September 2014
23 Reads

Monitoring of occupational and environmental aeroallergens-- EAACI Position Paper. Concerted action of the EAACI IG Occupational Allergy and Aerobiology & Air Pollution.

Allergy 2014 Oct 4;69(10):1280-99. Epub 2014 Aug 4.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-Universität Bochum (IPA), Bochum, Germany.

Exposure to high molecular weight sensitizers of biological origin is an important risk factor for the development of asthma and rhinitis. Most of the causal allergens have been defined based on their reactivity with IgE antibodies, and in many cases, the molecular structure and function of the allergens have been established. Significant information on allergen levels that cause sensitization and allergic symptoms for several major environmental and occupational allergens has been reported. Read More

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http://doi.wiley.com/10.1111/all.12456
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http://dx.doi.org/10.1111/all.12456DOI Listing
October 2014
14 Reads

[The correlation between the seasonal variation of house dust mite allergens exposure level in household and the level of asthma control in asthmatic children].

Zhonghua Er Ke Za Zhi 2014 Mar;52(3):177-83

National Key Discipline of Pediatrics, Ministry of Education, Allergy Department, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

Objective: The prevalence of allergic asthma has been rising continually which is correlated with the increasingly closed living environment. House dust mites are the major sources of indoor aeroallergens which induce asthma in sensitized people. To monitor the seasonal variation of house dust mite (HDM)-allergens exposure level in the asthmatic children, which was evaluated to show its correlation with the level of asthma control, HDM allergic sensitization and fraction of exhaled nitric oxide, and to provide basic data for HDM environmental control. Read More

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March 2014
44 Reads

Allergens on desktop surfaces in preschools and elementary schools of urban children with asthma.

Allergy 2014 Jul 18;69(7):960-963. Epub 2014 Apr 18.

Boston Children's Hospital, Boston, MA.

Desktop dust has been studied as a source of food allergen, but not as a source of potential aeroallergen exposure. Thirty-six wiped samples from desktop surfaces were collected from preschools and schools. Samples were analyzed for detectable levels of common aeroallergens including Alternaria, cockroach, dog, dust mite, cat, mouse, and rat allergens by immunoassay. Read More

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http://dx.doi.org/10.1111/all.12384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047193PMC
July 2014
43 Reads

Occupational Lung Diseases among Soldiers Deployed to Iraq and Afghanistan.

Authors:
Anthony M Szema

Occup Med Health Aff 2013 ;1

New York State Center for Biotechnology Stony Brook University School of Medicine, Stony Brook, NY 11794, USA ; Chief, Allergy Section, Veterans Affairs Medical Center, Northport, NY, 11768, USA.

Military personnel deployed to Iraq and Afghanistan, from 2004 to the present, has served in a setting of unique environmental conditions. Among these are exposures to burning trash in open air "burn pits" lit on fire with jet fuel JP-8. Depending on trash burned--water bottles, styrofoam trays, medical waste, unexploded munitions, and computers--toxins may be released such as dioxins and n-hexane and benzene. Read More

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http://www.esciencecentral.org/journals/occupational-lung-di
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http://dx.doi.org/10.4172/2329-6879.1000117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891866PMC
January 2013
15 Reads