1,068 results match your criteria Indian journal of pharmaceutical sciences[Journal]


Phytochemical Analysis and In vitro Antioxidant Studies of Plumeria obtusa L. Leaves.

Authors:
Nittya K Dogra

Indian J Pharm Sci 2016 Jan-Feb;78(1):169-71

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, India.

Plumeria (Apocynaceae) is a genus comprising mostly of lactiferous trees and deciduous shrubs. Plumeria obtusa L. is a widely available but pharmacologically lesser explored species of this genus. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852569PMC
May 2016
17 Reads

Estimation Based on Emission Wavelength of Dabigatran Etexilate Mesylate in Bulk and Capsule Dosage Form.

Indian J Pharm Sci 2016 Jan-Feb;78(1):166-9

Gokaraju Rangaraju College of Pharmacy, Osmania University, Hyderabad-500 090, India.

A simple, rapid, specific and highly sensitive spectrofluorimetric method has been developed for the quantification of dabigatran etexilate mesylate in bulk and capsule dosage form. A linear relationship was found between fluorescence intensity and concentration in the range of 0.01-1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852568PMC
May 2016
5 Reads

Evaluation of Immunomodulatory Activity of the Alkaloid Fraction of Trichopus zeylanicus Gaertn on Experimental Animals.

Indian J Pharm Sci 2016 Jan-Feb;78(1):161-6

Department of Pharmaceutics, J. K. K. Nattaraja College of Pharmacy, Namakkal District, Komarapalyam-638 183, India.

Trichopus zeylanicus Gaertn, (Trichopodaceae) is also known as "Arogyappacha" meaning the greener of health by tribal inhabitants (Kani tribes). This plant used as health tonic and rejuvenator. The whole plant material of Trichopus zeylanicus is defatted and successively extracted with methanol. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852567PMC
May 2016
15 Reads

Can Analgesic-abuse Nephropathy is a Fertile Groundfor for Rare Collecting Duct (Bellini Duct) Renal Cell Carcinoma or Merely a Coincidence?

Indian J Pharm Sci 2016 Jan-Feb;78(1):159-61

Department of Nephrology, SMS Medical College and Hospital, J. L. N. Marg, Jaipur-302 004, India.

Nonsteroid antiinflammatory drugs have been implicated as nephrotoxic drugs, causing both acute and chronic adverse effects that range from reversible ischemia to chronic kidney disease and urothelial tumors to renal cell carcinoma specially papillary subtype. We report one case of collecting duct (Bellini duct) renal cell carcinoma in patient with analgesic-abuse nephropathy. This young individual was suffering from ankylosing spondylitis since the age of 16 years and was consuming diclofenac and paracetamol (acetaminophen) combination for >15 years. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852566PMC
May 2016
11 Reads

Sensitivity of Interfibrillar and Subsarcolemmal Mitochondria to Cobalt Chloride-induced Oxidative Stress and Hydrogen Sulfide Treatment.

Indian J Pharm Sci 2016 Jan-Feb;78(1):151-8

School of Chemical and Biotechnology, SASTRA University, Thanjavur-613 401, India.

Oxidative stress plays a significant role not only in cardiovascular disease but also in non-communicable diseases, where it plays a significant role the mortality rate. Hydrogen sulfide, the biological gaseous signaling molecule that preserves mitochondria in its mode of action, is an effective cardioprotective drug. However, cardiac mitochondria comprise of two distinct populations, namely interfibrillar and subsarcolemmal mitochondria, which respond distinctly in cardiovascular disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852565PMC
May 2016
11 Reads

A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis.

Authors:
L J Liu J N Liu

Indian J Pharm Sci 2016 Jan-Feb;78(1):143-50

Department of Pharmaceutical Engineering, Heilongjiang University, Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Heilongjiang Province, Harbin, 150080, China.

The rhizome of Menispermum dauricum DC known as a traditional Chinese medicine, with high content of alkaloids, has been found to possess antitumor activity. In this research, an attempt to correlate fingerprinting with bioactivity was made for quality control of M. dauricum. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852564PMC
May 2016
33 Reads

Development of an Inhaled Sustained Release Dry Powder Formulation of Salbutamol Sulphate, an Antiasthmatic Drug.

Indian J Pharm Sci 2016 Jan-Feb;78(1):136-42

Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Kancheepuram-603 110, India.

The present research was aimed to develop and characterize a sustained release dry powder inhalable formulation of salbutamol sulphate. The salbutamol sulphate microparticles were prepared by solvent evaporation method using biodegradable polymer poly (D,L-lactic-co-glycolic acid) to produce salbutamol sulphate microparticle mixed with carrier respirable grade lactose for oral inhalation of dry powder. The drug content were estimated to produce 1 mg sustained release salbutamol sulphate per dose. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852563PMC
May 2016
13 Reads

Determination of Quality Standards for Draksharishta, a Polyherbal Ayurvedic Formulation.

Indian J Pharm Sci 2016 Jan-Feb;78(1):129-35

Sunandan Divatia School of Science, SVKM's NMIMS University, Vile Parle (W), Mumbai-400 056, India.

Draksharishta is an ayurvedic polyherbal formulation is prescribed for digestive impairment, respiratory disorders and weakness. Though the formula composition and therapeutic claims of draksharishta are part of the Ayurvedic Formulary of India, the scientific methods for its quality and safety evaluation are yet to be documented. The current work is an attempt to evaluate the quality parameters of draksharishta which has been checked vis a vis herbs used in the formulation by modern scientific control procedures like macroscopic and microscopic study, physico-chemical analysis, preliminary phytochemical analysis, thin layer chromatography and high performance thin layer chromatography to fix the quality standard of this formulation with reference to two marketed formulations i. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852562PMC
May 2016
4 Reads

Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines.

Indian J Pharm Sci 2016 Jan-Feb;78(1):120-8

Department of Clinical Analysis, Federal University of Santa Catarina, Campus Trinity, CEP: 88040-900, Florianópolis-SC, Brazil.

Recent studies have shown that gallic acid and its alkylesters induce apoptosis in different cell lines. Since new compounds with biological activity and less cytotoxicity to normal cells are necessary for cancer therapy, the aim of this study was to evaluate the cytotoxic effect of 1-(3,4,5-trihydroxyphenyl)-dodecylbenzoate on human acute myeloid leukemia K562 cells and on human acute lymphoblastic leukemia Jurkat cells. The cell viability was determined by MTT method. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852561PMC
May 2016
12 Reads

Lead, Cadmium and Nickel Contents of Some Medicinal Agents.

Indian J Pharm Sci 2016 Jan-Feb;78(1):111-9

Department of Pharmaceutical Chemistry and Natural Products, Dubai Pharmacy College, Dubai, United Arab Emirates.

Thirty nine brands of pharmaceutical dosage forms (28 tablets, 4 syrups, 6 suspensions and one chewing gum) that are available in United Arab Emirates pharmaceutical markets were investigated for the presence of three heavy metals; lead, cadmium and nickel. Amongst the samples, 13 products were manufactured locally in United Arab Emirates and 26 products were imported from around the world. The samples were prepared by acid digestion procedure and the resultant solutions were analyzed for heavy metals by using a validated graphite furnace atomic absorption spectrometric method. Read More

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http://dx.doi.org/10.4103/0250-474X.180260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852560PMC
May 2016
8 Reads

Evaluation of Mosquito Repellent Activity of Isolated Oleic Acid, Eicosyl Ester from Thalictrum javanicum.

Indian J Pharm Sci 2016 Jan-Feb;78(1):103-10

Department of Botany, Kongunadu Arts and Science College, Coimbatore-641 029, India.

To evaluate the traditional use, the mosquito repellent property of Thalictrum javanicum and to confirm the predicted larvicidal activity of the isolated compound, oleic acid, eicosyl ester from its aerial parts by PASS software, the present study was carried out using 4th instar stage larvae of the mosquitoes, Aedes aegypti (dengue vector) and Culex quinquefasciatus (filarial vector). Insecticidal susceptibility tests were conducted and the mortality rate was observed after 24 h exposure. The chitinase activity of isolated compound was assessed by using purified β-N-acetyl glucosaminidase (chitinase). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852559PMC
May 2016
32 Reads

Evaluation of Parmotrema reticulatum Taylor for Antibacterial and Antiinflammatory Activities.

Indian J Pharm Sci 2016 Jan-Feb;78(1):94-102

Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Kukrikheda, Barela, Jabalpur-483 001, India.

Lichens produce variety of secondary metabolites including depsides, depsidones and dibenzofurans having multifunctional activity in response to external environmental condition. Present study provides evidence for in vitro antibacterial and in vivo antiinflammatory activity of acetone and ethanol extracts of Parmotrema reticulatum. In vitro antibacterial activity was investigated against gram positive and gram negative bacteria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852582PMC
May 2016
16 Reads

Molecular and Computational Studies on Apoptotic Pathway Regulator, Bcl-2 Gene from Breast Cancer Cell Line MCF-7.

Indian J Pharm Sci 2016 Jan-Feb;78(1):87-93

Department of Biochemistry, Aligarh Muslim University, Aligarh-202 002, India.

Cancer is a dreadful disease constituting abnormal growth and proliferation of malignant cells in the body. Next to lung cancer, breast cancer is the most common form of cancer affecting women. The apoptotic pathway regulators, B cell lymphoma family of protein, play a key role in various malignancies defining cancer and their constitutive expression plays an integral role in breast cancer chemotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852581PMC
May 2016
20 Reads

Evaluation of In Vitro Antioxidant Potential of Cordia retusa.

Indian J Pharm Sci 2016 Jan-Feb;78(1):80-6

Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, India.

The present study was carried out to investigate the antioxidant potential, total flavonoid and phenolic content in extracts of aerial parts of Cordia retua (Vahl.) Masam. The samples such as ethyl acetate and ethanol extracts were tested using six in vitro models such as 2,2-diphenyl-1-picrylhydrazyl, nitric oxide radical, iron chelating, hydroxyl radical, superoxide radical scavenging activity and total antioxidant activity to evaluate the in vitro antioxidant potential of C. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852580PMC
May 2016
4 Reads

Stereoselective Reduction of Prochiral Ketones by Plant and Microbial Biocatalysts.

Indian J Pharm Sci 2016 Jan-Feb;78(1):73-9

Department of Mycology and Parasitology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Chiral alcohols are the key chiral building blocks to many enantiomerically pure pharmaceuticals. The biocatalytic approach in asymmetric reduction of corresponding prochiral ketones to the preparation of these optically pure substances is one of the most promising routes. The stereoselective reduction of different kinds of prochiral ketones catalyzed by various plants and microorganisms was studied in this work. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852578PMC
May 2016
82 Reads

Preparation and Characterization of PEG-albumin-curcumin Nanoparticles Intended to Treat Breast Cancer.

Indian J Pharm Sci 2016 Jan-Feb;78(1):65-72

Department of Pharmaceutics, Mother Teresa College of Pharmacy, Osmania University, Hyderabad, India.

The aim of present research was to prepare novel serum stable long circulating polymeric nanoparticles for curcumin with a modification to the well known and novel nanoparticle albumin bound technology. polyethylene glycol-albumin-curcumin nanoparticles were prepared using serum albumin and poly ethylene glycol using desolvation technique. Nanoparticles were characterized for encapsulation efficiency, particle size and surface morphology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852577PMC
May 2016
15 Reads

CoMFA, CoMSIA, HQSAR and Molecular Docking Analysis of Ionone-based Chalcone Derivatives as Antiprostate Cancer Activity.

Indian J Pharm Sci 2016 Jan-Feb;78(1):54-64

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Indore-452 001, India.

Androgen receptor has been proved to be effective site for treatment of prostate cancer. Molecular modeling methods performed on forty-three ionone based chalcones derivatives as anti-prostate cancer activity. The designed comparative molecular field analysis, comparative similarity indices analysis and hologram quantitative structure activity relationship models produced statistically significant results with the cross-validated correlation coefficients (q(2)) of 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852576PMC
May 2016
8 Reads

Antitarget Interaction, Acute Toxicity and Protein Binding Studies of Quinazolinedione Sulphonamides as GABA1 Antagonists.

Indian J Pharm Sci 2016 Jan-Feb;78(1):48-53

Department of Pharmaceutical Chemistry and Drug Design, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar-251 001, India.

Diseases characterized by recurrent seizures are known as epilepsy. One of the most important mechanisms for handling it is GABA1 receptor mediated inhibition. In the same context while studying the treatment of epilepsy we observed significant effects by derivatives of sulfonamides, which prompted us to design novel derivatives by means of in silico resources with antiepileptic effects. Read More

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http://www.ijpsonline.com/articles/antitarget-interaction-ac
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852575PMC
May 2016
10 Reads

Vitamin D Supplements in the Indian Market.

Indian J Pharm Sci 2016 Jan-Feb;78(1):41-7

Department of Pharmacology, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi-110 029, India.

It is now known that vitamin D deficiency is a worldwide health problem. In our country, as food fortification is lacking, supplementation with pharmaceutical preparations is the only means of treatment of vitamin D deficiency. We aimed to study the composition and availability of various vitamin D preparations in the Indian market, data about which was collected from annual drug compendium. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852574PMC
May 2016
9 Reads

Phytochemical, Antioxidant and Anticancer Activities of Extracts of Seven Fruits Found in the Southern Brazilian Flora.

Indian J Pharm Sci 2016 Jan-Feb;78(1):34-40

Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.

Methanol extracts of seven edible fruits found in southern Brazil: Garcinia achachairu, Rubus imperialis, Rubus rosaefolius, Solanum quitoense, Solanum sessiliflorun, Diospyros inconstans and Plinia glomerata, were evaluated for their total phenol content and antioxidant activity in different in vitro free radical scavenging models. In addition, studies were performed on cell viability of extracts of the seeds of G. achachairu against murine melanoma cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852573PMC
May 2016
13 Reads

Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract.

Indian J Pharm Sci 2016 Jan-Feb;78(1):27-33

Department of Cosmetic Chemistry, Faculty of Cosmetology, Academy of Cosmetics and Health Care, 00-252 Warsaw, Poland.

Centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. Thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epidermal barrier function. The aim of the present study was to evaluate the in vivo moisturizing and antiinflammatory properties of cosmetic formulations (oil-in-water emulsion cream and hydrogel) containing different concentrations of Centella asiatica extract. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852572PMC
May 2016
194 Reads

Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan.

Indian J Pharm Sci 2016 Jan-Feb;78(1):17-26

Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, University Road, Karachi 75270, Pakistan.

Cefuroxime is a second generation cephalosporin antibiotic with a broad spectrum activity against Gram positive and Gram negative bacteria. The purpose of this research work was to evaluate the pharmaceutical quality standards of four different brands of cefuroxime axetil 125 mg tablets with different price ranges purchased from retail pharmacies of Pakistan. The brands were tested for physicochemical evaluation and in vitro dissolution studies in different medium like 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852570PMC
May 2016
2 Reads

Combating Tuberculosis Infection: A Forbidding Challenge.

Indian J Pharm Sci 2016 Jan-Feb;78(1):8-16

Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad-382 481, India.

After 50 years drought, several drugs are looming from the pipeline to combat tuberculosis. They will serve as a boon to the field that has been burdened with primitive, inadequate treatments and drug-resistant bacterial strains. From the decades, due to lack of interest and resources, the field has suffered a lot. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852579PMC
May 2016
20 Reads

Oral Dispersible System: A New Approach in Drug Delivery System.

Indian J Pharm Sci 2016 Jan-Feb;78(1):2-7

Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa 25000, Pakistan.

Dosage form is a mean used for the delivery of drug to a living body. In order to get the desired effect the drug should be delivered to its site of action at such rate and concentration to achieve the maximum therapeutic effect and minimum adverse effect. Since oral route is still widely accepted route but having a common drawback of difficulty in swallowing of tablets and capsules. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852571PMC
May 2016
6 Reads

Editor's Note.

Authors:
Divakar Goli

Indian J Pharm Sci 2016 Jan-Feb;78(1)

Editor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852558PMC
May 2016
5 Reads

Forced Degradation Studies of Aloe Emodin and Emodin by HPTLC.

Indian J Pharm Sci 2015 Nov-Dec;77(6):795-8

Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, CBD Belapur, Navi Mumbai-400 614, India.

Anthraquinones are natural phenolic compounds, which are reported to act as anti-aging, anti-inflammatory, antioxidant, anti-cancer, laxative and antitumor agents. They are abudant in plants like candle bush, aloes, cascara bark and rhubarb. The present work was to observe the effect of different forced degradation conditions by high-performance thin layer chromatography on potential markers i. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778244PMC
March 2016
2 Reads

In vitro Cytotoxicity of Methanol Extract from Aerial Parts of Aralia cachemirica and Purified Continentalic Acid.

Indian J Pharm Sci 2015 Nov-Dec;77(6):792-5

Indian Institute of Integrative Medicine, Jammu Tawi-180 001, India.

The present study was designed to evaluate the in vitro cytotoxic effect of methanol extract of aerial parts including stems, leaves and twigs of Aralia cachemirica and purified continentalic acid isolated from this extract against a panel of human cancer cell lines of varied tissues. Percentage of growth inhibition was evaluated by sulphorhodamine B assay. Purified continentalic acid showed moderate cytotoxicity against all the cell lines used. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778243PMC
March 2016
11 Reads

In vitro Antibacterial Activity of Aqueous and Ethanol Extracts of Aristolochia indica and Toddalia asiatica Against Multidrug-Resistant Bacteria.

Indian J Pharm Sci 2015 Nov-Dec;77(6):788-91

Department of Plant Biology and Biotechnology, Loyola College (Autonomous), Chennai-600 034, India.

Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffective against multidrug-resistant bacteria. Read More

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http://dx.doi.org/10.4103/0250-474X.174991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778242PMC
March 2016
28 Reads

Simultaneous Estimation of Aloe Emodin and Emodin from Rheum emodi, Cassia alata and Aloes by HPTLC.

Indian J Pharm Sci 2015 Nov-Dec;77(6):783-7

Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, C.B.D. Belapur, Navi Mumbai-400 614, India.

A simple, precise, specific, accurate high performance thin layer chromatography method was developed for simultaneous estimation of aloe emodin and emodin from medicinal plants like Rheum emodi (Rhubarb), Barbados aloes (dried juice of Aloe barbadensis leaf) and Cassia alata (Candle bush). Thin layer chromatographic aluminum plates pre-coated with silica gel 60 F254 was used as the stationary phase for chromatographic separation of the drugs. Toluene:ethyl acetate:formic acid (10:2:1 v/v/v) was selected as mobile phase and analysis was carried out in absorbance mode at iso-absorptive wavelength of 263 nm. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778241PMC
March 2016
5 Reads

Antioxidant Studies on Ethanol Extracts from Two Selected Genera of Indian Lamiaceae.

Authors:
G Ramu S P Dhanabal

Indian J Pharm Sci 2015 Nov-Dec;77(6):780-2

Department of Pharmacognosy, J. S. S. College of Pharmacy, Udhagamandalam-643 001, India.

The present work is targeted to evaluate antioxidant activity of ethanol extracts from the leaves of Plectranthus mollis and Salvia officinalis belonging to family Lamiaceae using nitric oxide scavenging, hydrogen peroxide scavenging, ferric reducing antioxidant power assay and lipid peroxidation methods. The results of the study indicate that the leaf extracts of both the plants possess in vitro antioxidant activity. The higher amount of flavanoids and phenolic compounds may correspond to their greater antioxidant activity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778240PMC
March 2016
16 Reads

Antipsychotic Trials in Schizophrenia from India: A Systematic Review and Meta-analysis.

Authors:
S Grover S Sarkar

Indian J Pharm Sci 2015 Nov-Dec;77(6):771-9

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry-605 006, India.

Ethnic and regional variations have been found in the pharmacological treatment response. Though many efficacy studies have been conducted in India for antipsychotic treatment modalities of schizophrenia, there is a lack meta-analytic data of the existing literature from India. This study aimed to conduct a systematic review and meta-analysis of the antipsychotic treatment trials of schizophrenia in the Indian context. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778239PMC
March 2016
6 Reads

Formulation of Thermosensitive in situ Otic Gel for Topical Management of Otitis Media.

Indian J Pharm Sci 2015 Nov-Dec;77(6):764-70

Department of Pharmaceutics, Kamla Nehru College of Pharmacy, Butibori, Nagpur-441 108, India.

Antibiotics and antiinflammatory agents are the primary and main therapeutic categories in the treatment of otitis media. One of the simpler and feasible approaches of minimizing the problem of repeated use and subsequent resistance is development of sustained release formulation. Therefore, the present investigation aimed to develop a sustained release in situ gel formulation containing combination of broad spectrum antibiotic and antiinflammatory agents for the management of otits media. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778238PMC
March 2016
4 Reads

Screening and Toxicity Analysis of Catechin Isomers Against FemA Protein.

Indian J Pharm Sci 2015 Nov-Dec;77(6):758-63

Department of Biotechnology, Thapar University, Patiala-147 004, India.

Fem proteins are the essential structural proteins of various gram-positive bacteria. These are of three different types namely FemX (FmhB), FemA and FemB. Only two Fem protein crystallographic structures are available till date, one for FemA in Staphylococcus aureus and another for FemX in Weissella viridescensis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778237PMC
March 2016
11 Reads

Analytical Quality by Design Approach in RP-HPLC Method Development for the Assay of Etofenamate in Dosage Forms.

Indian J Pharm Sci 2015 Nov-Dec;77(6):751-7

Analytical Research Laboratory, Raghavendra Institute of Pharmaceutical Education and Research, Anantapur-515 721, India.

By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of etofenamate in dosage form has been optimized using analytical quality by design approach. Unlike routine approach, the present study was initiated with understanding of quality target product profile, analytical target profile and risk assessment for method variables that affect the method response. A liquid chromatography system equipped with a C18 column (250×4. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778236PMC
March 2016
12 Reads

Development of Validated Bioanalytical HPLC-UV Method for Simultaneous Estimation of Amlodipine and Atorvastatin in Rat Plasma.

Indian J Pharm Sci 2015 Nov-Dec;77(6):742-50

Department of Pharmaceutical Chemistry, SNJB's SSDJ College of Pharmacy, Chandwad-423 101, India.

A simple, economical and robust analytical high-performance liquid chromatography-ultraviolet method was developed and validated for simultaneous chromatographic elution of two cardiovascular drugs viz. amlodipine and atorvastatin in biological fluid for the first time. Only two liquid chromatography-mass spectrometry/mass spectrometry methods are available in literature for quantitation of selected pair of analytes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778235PMC
March 2016
6 Reads

Effect of Structural Changes in Proteins Derived from GATA4 Nonsynonymous Single Nucleotide Polymorphisms in Congenital Heart Disease.

Indian J Pharm Sci 2015 Nov-Dec;77(6):735-41

Department of Studies in Zoology, Genomics Laboratory, University of Mysore, Manasagangotri, Mysore-570 006, India.

Congenital heart disease is the most common type of birth defect. The single nucleotide polymorphism in GATA4 is associated with various congenital heart disease phenotypes. In the present study, we analysed the nonsynonymous single nucleotide polymorphism of GATA4, which are involved in congenital heart disease by predicting the changes in protein structures. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778234PMC
March 2016
4 Reads

Physicochemical and Antioxidant Assays of Methanol and Hydromethanol Extract of Ariel Parts of Indigofera tinctoria Linn.

Indian J Pharm Sci 2015 Nov-Dec;77(6):729-34

Department of Bioscience and Biotechnology, Banasthali University, Jaipur-304 022, India.

Free radicals or reactive oxygen indices give rise to oxidative injury, which is a fundamental mechanism underlying a number of disease like diabetes, cancer, neurodegenerative disorders. Deleterious effects of reactive oxygen species can be nullified by using different natural antioxidants derived from plants Indigofera tinctoria is such plant. This study was planned in order to trace and determine the antioxidant capability of Indigofera tinctoria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778233PMC
March 2016
7 Reads

Quality by Design Approach for Simultaneous Estimation of Doxycycline Hyclate and Curcumin by RP-HPLC Method.

Indian J Pharm Sci 2015 Nov-Dec;77(6):723-8

Analytical Research and Development Division, Indian Pharmacopoeia Laboratory, Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Government of India, Ghaziabad-201 002, India.

A simple, rapid, reliable, robust and optimized reversed phase high performance liquid chromatographic method for simultaneous estimation of doxycycline hyclate and curcumin was successfully developed and validated as per International Conference on Harmonization guidelines. The objective was achieved in terms of well separated peaks within 10 min on a Waters Sunfire C8 column with dimensions of 250×4.6 mm, particle size 5. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778232PMC
March 2016
11 Reads

Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis.

Indian J Pharm Sci 2015 Nov-Dec;77(6):715-22

The State Key Lab of Pharmaceutical Biotechnology, College of life Sciences, Nanjing University, Nanjing 210093, P. R. China.

Psoralea Fructus, the dried and ripe fruit of Psoralea corylifolia L., have been used as traditional medicine. There is substantial evidence that multiple constituents are responsible for the beneficial effects of this medicine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778231PMC
March 2016
9 Reads

Effect of Different Polymer Concentration on Drug Release Rate and Physicochemical Properties of Mucoadhesive Gastroretentive Tablets.

Indian J Pharm Sci 2015 Nov-Dec;77(6):705-14

Department of Pharmaceutical Sciences, Faculty of Technology and Engineering, Kalabhavan, M. S. University of Baroda, Vadodara-390 001, India.

Mucoadhesive tablets have emerged as potential candidates for gastroretentive drug delivery providing controlled release along with prolonged gastric residence time. Gastroretentive mucoadhesive tablets could result in increased bioavailability due to prolonged gastric residence time. A hydrophilic matrix system was developed as mucoadhesion is achievable on appropriate wetting and swelling of the polymers used. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778230PMC
March 2016
11 Reads

Comparison of Calcium Phosphate and Zinc Oxide Nanoparticles as Dermal Penetration Enhancers for Albumin.

Indian J Pharm Sci 2015 Nov-Dec;77(6):694-704

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Dermal drug delivery is highly preferred by patients due to its several advantages. Protein therapeutics have attracted huge attention recently. Since dermal delivery of proteins encounter problems, in this investigation, zinc oxide nanoparticles and calcium phosphate nanoparticles were compared as enhancers for dermal permeation of albumin. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778229PMC
March 2016
9 Reads

Prospective Observational Study of Adverse Drug Reactions of Anticancer Drugs Used in Cancer Treatment in a Tertiary Care Hospital.

Indian J Pharm Sci 2015 Nov-Dec;77(6):687-93

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh-160 012, India.

Adverse drug reactions associated with the use of anticancer drugs are a worldwide problem and cannot be ignored. Adverse drug reactions can range from nausea, vomiting or any other mild reaction to severe myelosuppression. The study was planned to observe the suspected adverse drug reactions of cancer chemotherapy in patients aged >18 years having cancer attending Postgraduate Institute of Medical Education and Research, Chandigarh. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778228PMC
March 2016
11 Reads

Prenatal Exposure to Silver Nanoparticles Causes Depression Like Responses in Mice.

Indian J Pharm Sci 2015 Nov-Dec;77(6):681-6

Physiology Research Center and Department of Physiology, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Despite increasing studies on silver nanoparticles, their mechanism of action is not so clear, especially their probable toxicity on reproduction procedure, developmental process and offspring behavior. Therefore in the present study the effect of silver nanoparticles exposure during gestational period on offspring's depression behavior was assessed. Thirty virgin female mice were divided into three groups (n=10 for each group) including: one control and two experimental groups, which received an equal volume (0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778227PMC
March 2016
3 Reads

Fabrication and Characterization of Sertaconazole Nitrate Microsponge as a Topical Drug Delivery System.

Indian J Pharm Sci 2015 Nov-Dec;77(6):675-80

Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Ahmednagar-423 603, India.

Present study was taken up to develop a topical formulation that releases the drug in controlled manner, reduce the side effects associated with topical drug delivery and improve product efficacy with aid of microsponges. Microsponges loaded with sertaconazole nitrate were prepared by using quasi emulsion solvent diffusion with five different proportions of the polymer (Eudragit RS 100). The developed microsponges were analyzed for particle size, production yield, entrapment efficiency and drug content. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778226PMC
March 2016
12 Reads

In vitro Screening for Antioxidant, Antimicrobial, and Antidiabetic Properties of Some Korean Native Plants on Mt. Halla, Jeju Island.

Indian J Pharm Sci 2015 Nov-Dec;77(6):668-74

College of Applied Life Sciences, The Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University, Jeju 690-756, Republic of Korea.

In this study, Prunus padus, Lonicera caerulea, Berberis amurensis, and Ribes maximowiczianum, which are mainly distributed on Mt. Halla, Jeju Island, have been investigated for their antioxidant, antimicrobial, and antidiabetic activities. The methanol extracts of R. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778225PMC
March 2016
3 Reads

Flavonoids, Antioxidant Activity and Aroma Compounds Analysis from Different Kinds of Tartary Buckwheat Tea.

Indian J Pharm Sci 2015 Nov-Dec;77(6):661-7

National Research and Development Center for Coarse Cereal Processing, Chengdu University, Chengdu 610 106, People's Republic of China.

The rutin, quercetin concentrations, antioxidant activity, and aroma compounds in different commercial tartary buckwheat tea were analyzed in our study. Results revealed that the materials and the processing protocol affected the chemical composition and activity of tartary buckwheat tea. Rutin and quercetin concentrations, antioxidant activity were significantly different in various kinds of tartary buckwheat tea, where the whole bran tea and the whole plant tea had the lower rutin, but higher quercetin concentrations and higher antioxidant activity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778224PMC
March 2016
16 Reads

Cytotoxic and Antitumour Studies of Acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its Transition Metal Complexes.

Indian J Pharm Sci 2015 Nov-Dec;77(6):655-60

Department of Chemistry, University of Calicut, Malappuram-673 635, India.

Cytotoxic activities of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone (L2H) and its seven different metal complexes were studied. Of these, IC50 value of the copper complex was found to be 46 μg/ml. Antitumour studies of this copper complex was carried out using Daltons Lymphoma Ascites cell-induced solid tumour model and Ehrlich's Ascites Carcinoma cell-induced ascites tumour model. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778223PMC
March 2016
6 Reads

Comparative Evaluation of Specific Phytochemical Indicatives in Cirivilvādi Kaṣāya Prepared Freshly and at Commercial Scale.

Indian J Pharm Sci 2015 Sep-Oct;77(5):650-4

T. Stanes and Company Limited, 8/23-24, Race Course Road, Coimbatore-641 018, India.

Kaṣāya or decoction is an Ayurvedic dosage form, prescribed based on the stage of the disease according to the principles of Ayurveda. This dosage form is traditionally prepared fresh and consumed on the same day but for the sake of convenience; the process of preparation has been modified so that it can be stored with longer shelf life, easy availability and produced in large quantities. There is a need to understand the implications of this modification in terms of chemical changes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700724PMC
January 2016
17 Reads

A Study of Agastachis Herba on Ovalbumin-induced Asthma in the Mouse.

Indian J Pharm Sci 2015 Sep-Oct;77(5):645-50

School of Korean Medicine, Pusan National University, Yangsan, Korea.

Agastachis Herba is one of the well-known medicinal herbs in Korean traditional medicine. This study was taken up to examine the beneficial effects of Agastachis Herba on a mice model of asthma. BALB/c mice were sensitized and challenged with ovalbumin to produce a murine model of asthma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700723PMC
January 2016
8 Reads

Phytochemical Screening, Proximate Analysis and Antioxidant Activity of Dracaena reflexa Lam. Leaves.

Indian J Pharm Sci 2015 Sep-Oct;77(5):640-4

Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar-249 404, India.

In the present study, the antioxidant activity of successive leaf extracts of Dracaena reflexa was investigated using the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl and reducing power by ferric reducing antioxidant power assay. Methanol extract was found potent in both the assays. IC50 values of 1,1-diphenyl-2-picrylhydrazyl assay for methanol extract was 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700722PMC
January 2016
30 Reads