Search Our Scientific Publications & Authors

J Autism Dev Disord 2018 Dec 15. Epub 2018 Dec 15.

Department of Studies in Food Science and Nutrition, University of Mysore, Mysuru, India.

Research literature on dietary patterns & eating habits of children with Autism Spectrum Disorder (ASD) in India is limited. To explore this, a pilot study (n = 53) which included 45 boys and 8 girls (age group of 2-13 years) was conducted. Three day food records, Food Frequency Questionnaire and Children Eating Behavior Inventory were used to assess the dietary intakes and mealtime behavior problems respectively. Read More

Tob Control 2018 Dec 15. Epub 2018 Dec 15.

Health Promotion Division, Public Health Foundation of India, Gurugram, India.

Background: Despite the importance of decreasing tobacco use to achieve mortality reduction targets of the Sustainable Development Goals in low-income and middle-income countries (LMICs), evaluations of tobacco control programmes in these settings are scarce. We assessed the impacts of India's National Tobacco Control Programme (NTCP), as implemented in 42 districts during 2007-2009, on household-reported consumption of bidis and cigarettes.

Methods: Secondary analysis of cross-sectional data from nationally representative Household Consumer Expenditure Surveys (1999-2000; 2004-2005 and 2011-2012). Read More

Biosens Bioelectron 2018 Dec 8;126:758-766. Epub 2018 Dec 8.

Department of Chemistry and Institute of BioPhysio Sensor Technology (IBST), Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes. The linear calibration curves were obtained in the concentration range of 0. Read More

Acta Trop 2018 Dec 13. Epub 2018 Dec 13.

Indian Institute of Public Administration, Delhi, India.

Climate change is considered as a distal determinant of public health which is increasing in importance. India, as an example, has a national action plan for climate change and human health. Sub-national (State) plans for climate change also exist, taking into account the health sector. Read More

Carbohydr Polym 2019 Feb 14;206:854-862. Epub 2018 Nov 14.

Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:

Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. Read More

Carbohydr Polym 2019 Feb 31;206:132-140. Epub 2018 Oct 31.

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address:

Hyaluronic acid from metabolically engineered Lactococcus lactis (HA) was characterized for its biocompatibility and immobilized on the polyethylene terephthalate (PET) surface. HA was chemically crosslinked on hydrolyzed PET (hPET) surface to form HA-coated PET (hPET-HA). The unmodified and modified PET were characterized by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), contact angle measurement, thermogravimetric analysis (TGA), universal testing machine (UTM) and assessed for their biocompatibility. Read More

Chemosphere 2018 Dec 4;219:504-509. Epub 2018 Dec 4.

School of Engineering, Indian Institute of Technology, Mandi, 175005, Himachal Pradesh, India. Electronic address:

A zeolite-reduced graphene oxide (ZrGO) based composite was synthesized to remove arsenic from water. To make a low-cost adsorbent, zeolite was synthesized using an inexpensive waste material; fly ash, which was further used to produce the ZrGO composite. Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Raman spectra were used to characterize the morphology and surface composition of the synthesized materials. Read More

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

Plant Physiol Biochem 2018 Dec 10;135:160-166. Epub 2018 Dec 10.

Department of Horticultural Sciences and Center for Coffee Research & Education, Texas A&M University, TAMU 2133, College Station, TX, 77843, USA.

A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO ‧ HO) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days. Read More

J Colloid Interface Sci 2018 Dec 4;538:587-596. Epub 2018 Dec 4.

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 426066, Madhya Pradesh, India. Electronic address:

The binding interaction of a prospective anti-cancer photosensitizer, norharmane (NHM, 9H-pyrido[3,4-b]indole) with double stranded RNA reveals a primarily intercalative mode of binding. Steady-state and time-resolved fluorescence spectroscopic results demonstrate the occurrence of drug-RNA binding interaction as manifested through environment-sensitive prototropic equilibrium of NHM. However, the key finding of the present study lies in unraveling the complexities in the NHM-RNA binding thermodynamics. Read More

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Department of Kriyasharir Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Reinwardtia indica (Lineceae) is a medicinal plant cultivated in the Himalayan region. It is effectively used in folk medicines for the treatment of various health complications. In the present study, the shade dried leaves and stem were extracted in three different solvents such as ethyl acetate, ethanol, and hydro-alcoholic. Read More

Behav Processes 2018 Dec 12. Epub 2018 Dec 12.

School of Life Sciences, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address:

Understanding the effects of anthropogenic disturbance on species' behaviour is crucial for conservation planning, considering the extent of habitat loss. We investigated the influence of anthropogenic disturbances including agriculture, urbanisation, protected areas, and the presence of novel predators, on the temporal and spatial behaviour of sympatric forest antelope (Tragelaphus scriptus, Philantomba monticola, Sylvicapra grimmia, and Cephalophus natalensis) in an anthropogenic matrix containing forest fragments in the Indian Ocean Coastal Belt of South Africa. We integrated land-use types with camera-trap data and compared activity patterns using circular statistics and occupancy modelling. Read More

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007. India.

Despite the availability of drugs to treat Leishmaniasis, various other factors including drug resistance and adverse side effects encourage the researchers to search for new strategies and alternatives for treating Leishmaniasis. Repurposing and devising combination therapy with the existing small molecules would serve as an alternative strategy to address the issue, especially the drug resistance. Hence, here we report LeishInDB, a web-accessible resource of small molecule inhibitors having a varying degree of activity towards Leishmania sp. Read More

Chemphyschem 2018 Dec 15. Epub 2018 Dec 15.

Department of Materials Science, Indian Association for the Cultivation of Science,Jadavpur, Kolkata-700032,India., INDIA.

We have envisaged the hydrogen evolution and oxygen evolution reaction (HER and OER) on two-dimensional (2D) noble metal free titanium disulfide TiS2 monolayer, which belongs to the exciting family of transition metal dichalcogenides (TMDCs). Our theoretical investigation to probe HER and OER on both H- and T- phase of 2D TiS2 is based on the electronic structure calculations witihin the framework of Density Functional Theory (DFT). Since TiS2 is the lightest element among the group IV transition metal dichalocogenides, it is worth exploring the catalytic activity of TiS2 monolayer through the functionalization at the anion (S) site substituting with P, N and C dopants as well as by incorporating single sulfur vacancy defect. Read More

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.

Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

MACS Agharkar Research Institute, G.G. Agarkar Road, Pune, 411004, Maharashtra, India.

Candidatus Methylocucumis (Mcu.) oryzae, strain Sn10-6, a Gram-negative, pale pink pigmented, motile, large Type I methanotroph (3-6 µm × 1.5-2 µm) was recently isolated from an Indian rice field. Read More

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Malaria Research, Dwarka Sector 8, New Delhi, 110077, India.

Author Atul Yadav would like to present his name as Atul only to be the same with his previous publications. The original article has been corrected. Read More

Sci Rep 2018 Dec 14;8(1):17844. Epub 2018 Dec 14.

Plant Molecular Biology Group, Biotechnology Department, Indian Institute of Technology Roorkee, Roorkee, 247667, India.

Apple scab disease caused by the fungus Venturia inaequalis is a devastating disease that seriously affects quality and yield of apples. In order to understand the mechanisms involved in scab resistance, we performed gas chromatography-mass spectrometry based metabolomics analysis of the cell culture of scab resistant cultivar 'Florina' and scab susceptible cultivar 'Vista Bella' both prior -to and -following treatment with V. inaequalis elicitor (VIE). Read More

BMJ Open 2018 Dec 14;8(12):e020854. Epub 2018 Dec 14.

Addictions Research Group, Sangath, Porvorim, Goa, India.

Introduction: The aim of this review is to provide the first consolidation of the policy environment surrounding alcohol-related societal harm in India giving researchers and policy-makers a clearer base for future reforms. This review is also an important adaptation on the scoping review method for policy reviews in low-resource settings that may serve as an example for other policy reviews in similar settings.

Methods And Analysis: We will undertake a scoping review with policy relevant adaptations in order to map the alcohol-related policy environment in India. Read More

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Chemical Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand 247 667, India.

Inappropriate and disproportionate use of antibiotics is contributing immensely to the development of antibiotic resistance in bacterial species associated with food contamination. Use of natural products in combination can be a potent alternative hurdle strategy to inactivate foodborne pathogens. Here, we explored pro-oxidant properties of essential oil inalool and itamin C in combination with opper (LVC) in combating foodborne pathogens and a subsp. Read More

Bioorg Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Bioorganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road Jammu, 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IIIM Campus, Jammu 180001, India. Electronic address:

Inhibitors for NorA efflux pump of Staphylococcus aureus have attracted the attention of many researchers towards the discovery and development of novel efflux pump inhibitors (EPIs). In an attempt to find specific potent inhibitors of NorA efflux pump of S. aureus, a total of 15 amino acid conjugates of 3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid (4-18) were synthesized using a simple convenient synthetic approach and bioevaluated against NorA efflux pump. Read More

Int J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Early detection of Atrial Fibrillation (AF) is a public health priority across the globe because AF-related strokes are preventable. Despite an ongoing stroke epidemic in India, a public health strategy for AF screening and treatment is missing because the epidemiology of AF in India remains poorly defined.

Methods: This population-based study used mobile technology to derive age and sex-stratified AF prevalence by screening 7 participants in each of six age and sex strata (age 40-55, 56-65, 65+, and male and female) from 50 villages (2100 participants). Read More

Biomed Pharmacother 2019 Jan 20;109:1698-1708. Epub 2018 Nov 20.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400 056, India.

Depression is a heterogeneous disorder and has been regarded as an inflammatory disease. The aerial parts of the Convolvulus pluricaulis are used in Indian traditional medicines for the management of nervous disorders. However, the influence of methanolic extract of aerial parts of Convolvulus pluricaulis (CPE) on a chronic animal model of depression has not been investigated yet, and associated biochemical changes are still unclear. Read More

Colloids Surf B Biointerfaces 2018 Dec 4;175:281-290. Epub 2018 Dec 4.

Department of Materials Science and Engineering, Indian Institute of Technology, Delhi, 110016, India. Electronic address:

Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. Read More

Pharmacol Rep 2018 Oct 25;71(1):167-174. Epub 2018 Oct 25.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India. Electronic address:

Background: PGs are involved in cellular communication and cancer biology. The role of CS in melanoma and fibrosarcoma cell lines was explored by using chondroitin AC lyase (PsPL8A).

Methods: The proliferation of mouse fibroblast L929, human melanoma (SK-Mel 28) and fibrosarcoma (HT-1080) cell lines after treatment with chondroitin AC lyase (PsPL8A) was studied by MTT assay. Read More

J Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India. Electronic address:

Recombinant protein production by various host organisms is strictly regulated, which is determined mainly by host cell genetics and maintenance of process variables within desirable limits in a reactor. Since the process dynamics typically exhibit nonlinear interactions amongst the critical process variables, the commonly employed controllers are suboptimal for control of most bioprocesses. In this article, we present the implementation of an augmented controller for improving the production of recombinant human serum albumin using Pichia pastoris. Read More

Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

Glob Chang Biol 2019 Jan 22;25(1):155-173. Epub 2018 Nov 22.

Institute of Crop Science and Resource Conservation INRES, University of Bonn, Bonn, Germany.

Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Read More

Head Neck 2018 Dec 13. Epub 2018 Dec 13.

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

Background: Cancer of oral cavity is a seriously growing problem in many parts of the world. In Indian subcontinent, most of these cases have been attributed to the use of tobacco-related products. This study is focused on the identification of distinguishing metabolites of oral cancer in comparison with tobacco snuff dippers and healthy controls. Read More

Ecol Lett 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology, Université de Moncton, Moncton, New Brunswick, E1A 3E9, Canada.

Material and energy flows among ecosystems can directly and indirectly drive ecosystem functions. Yet, how populations of consumers respond to allochthonous inputs at a macroecological scale is still unclear. Using a meta-analysis spanning several biomes, we show that the abundance of recipient populations is 36-57% larger with increased allochthonous inputs. Read More

Parasite Immunol 2018 Dec 12:e12611. Epub 2018 Dec 12.

Division of Biochemistry, ICAR-Indian Veterinary Research Institute, Izatnagar, India, 243122.

Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of the innate immunity, by binding to complement C3. Read More

Chemphyschem 2018 Dec 12. Epub 2018 Dec 12.

Indian Institute of Science, Department of Organic Chemistry, Tala Marg, 560012, Bangalore, INDIA.

Excited-state proton transfer efficiency of a tetraarylpyrene derivative, 1,3,6,8-tetrakis(4-hydroxy-2,6-dimethylphenyl)pyrene (TDMPP) was investigated thoroughly in the presence of various surfactant assemblies, such as micelles, vesicles, etc. The confined microheterogeneous environments can significantly retard the extent of excited-state proton transfer process, resulting in a distinguishable optical signal compared to that in the bulk medium. Physical characteristics of the surfactant assemblies such as order, interfacial hydration and surface charge influence the proton transfer process, and allow multiparametric sensing. Read More

Org Lett 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry , Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal - 462 066 , India.

A gold-catalyzed 1,2-oxyalkynylation of N-allenamides with ethylnylbenziodoxolones (EBXs) has been achieved for the first time. The reaction, which follows a redox-neutral Au(I)/Au(III) catalytic pathway, was enabled in an attempt to exhaust the EBX reagents atom-economically by putting the nucleophilic carboxylate part of EBXs to appropriate use. This constitutes the first example for gold-catalyzed β-alkynylation of N-allenamides to construct highly valuable 1,3-enynes. Read More

Org Biomol Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India.

A simple and efficient method for regioselective synthesis of 3-arylquinolines is described from α-aminoacetophenones and trans-β-nitrostyrenes using 20 mol% iodine monobromide as a catalyst in acetonitrile solvent at 80 °C. The present method involves tandem reaction of α-aminoacetophenones and trans-β-nitrostyrenes, formation of two new C-C bonds and cleavage of one C-C bond in a single step. The salient features of the protocol are metal- and oxidant-free reaction conditions, broad substrate scope, and good yields. Read More

Retrovirology 2018 Dec 14;15(1):77. Epub 2018 Dec 14.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Background: HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease (CVD). We investigated these changes in the first 96 weeks of treatment with low-dose stavudine or tenofovir regimens.

Methods: This is a secondary analysis of a double blind, randomised controlled trial performed in South-Africa, Uganda and India comparing low-dose stavudine (20 mg twice daily) with tenofovir in combination with efavirenz and lamivudine in antiretroviral-naïve adults (n = 1067) (Clinicaltrials. Read More

Qual Health Res 2018 Dec 14:1049732318817047. Epub 2018 Dec 14.

5 Centre for Chronic Disease Control & Public Health Foundation of India, Gurgaon, Haryana, India.

Tobacco cessation is an important intervention to reduce mortality from ischemic heart disease, the leading cause of death in India. In this study, we explored facilitators, barriers, and cultural context to tobacco cessation among acute coronary syndrome (ACS, or heart attack) patients and providers in a tertiary care institution in the south Indian state of Kerala, with a focus on patient trajectories. Patients who quit tobacco after ACS expressed greater understanding about the link between tobacco and ACS, exerted more willpower at the time of discharge, and held less fatalistic beliefs about their health compared to those who continued tobacco use. Read More

Phys Rev Lett 2018 Nov;121(22):226401

Department of Physics, Northeastern University, Boston, Massachusetts 02115, USA.

Materials with tunable charge and lattice degrees of freedom provide excellent platforms for investigating multiple phases that can be controlled via external stimuli. We show how the charge-ordered ferroelectric oxide Ag_{2}BiO_{3}, which has been realized experimentally, presents a unique exemplar of a metal-insulator transition under an external electric field. Our first-principles calculations, combined with a symmetry analysis, reveal the presence of a nearly ideal hourglass-Dirac-semimetal state in the nonpolar structure of Ag_{2}BiO_{3}. Read More

Phys Rev Lett 2018 Nov;121(22):221802

University of Wisconsin, Madison, Wisconsin, USA.

The first evidence of events consistent with the production of a single top quark in association with a photon is reported. The analysis is based on proton-proton collisions at sqrt[s]=13  TeV and recorded by the CMS experiment in 2016, corresponding to an integrated luminosity of 35.9  fb^{-1}. Read More

Methods Mol Biol 2019 ;1903:45-59

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India.

Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of small molecules offers opportunities to explore the repurpose-able potential of existing pharmacopoeia. This method gains further importance, especially, in the context of development of drugs against infectious diseases, some of which pose serious complications due to emergence of drug-resistant pathogens. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.

Objective: To study the incidence, clinical risk factors and outcome of thrombotic events in pediatric age group of 1 mo-12 y.

Methods: This prospective observational study was conducted in a tertiary care institute from September 2015 through October 2017. Forty nine children with thrombosis from 1 mo-12 y were enrolled. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Tata Motors Hospital, Jamshedpur, Jharkhand, India.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Division of Neonatology, Department of Pediatrics, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.

Objective: To evaluate the feeding performance of infants with bronchopulmonary dysplasia (BPD) on paladai.

Methods: This cross-sectional study was performed in a level III neonatal unit in North India from March through August 2012. Nineteen infants (27-32 wk of gestation) were enrolled; 9 in BPD group (oxygen requirement for at least 28 d) and 10 in 'No BPD' group. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Asha Kirana Hospital, Hebbal Industrial Housing Area, Ring Road, Hebbal, Mysore 570016, Karnataka, India.

Objectives: In India, access to free anti-retroviral therapy has improved the survival of perinatally human immunodeficiency virus (HIV) infected children resulting in the transition of many such children to adulthood. This study aims to understand the social-outcomes and quality of life (QOL) among these adults.

Methods: This cross-sectional study was conducted in two tertiary HIV care centers in south India. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of ENT, Affiliated Renhe Hospital of China, Three Gorges University, Second Clinical Medical College of China, No. 410 Yiling Road, Yi Chang, Hubei, China.

Objective: Day surgery for tonsillectomy has become more and more popular in China. However, many parents face difficulties to cope up with the pain and side effects after surgery. The present study was aimed to examine the efficacy of telephone follow-up on children's post-discharge recovery after tonsillectomy. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Nalanda Medical College, Patna, 800013, India.

Sci Adv 2018 Dec 12;4(12):eaat9658. Epub 2018 Dec 12.

National Center for Atmospheric Research, Climate and Global Dynamics Laboratory, 1850 Table Mesa Drive, Boulder, CO 80305, USA.

The mechanisms driving glacial-interglacial changes in the climate of the Indo-Pacific warm pool are poorly understood. Here, we address this question by combining paleoclimate proxies with model simulations of the Last Glacial Maximum climate. We find evidence of two mechanisms explaining key patterns of ocean cooling and rainfall change interpreted from proxy data. Read More

J Glob Health 2019 Jun;9(1):010408

Department of Clinical Sciences, Liverpool School of Tropical Medicine (LSTM), Liverpool, UK.

Background: Lack of menstrual knowledge, poor access to sanitary products and a non-facilitating school environment can make it difficult for girls to attend school. In India, interventions have been developed to reduce the burden of menstruation for school girls by government and non-governmental organizations (NGOs). We sought to identify challenges related to menstruation, and facilitators of menstrual management in schools in three states in India. Read More

Front Immunol 2018 28;9:2798. Epub 2018 Nov 28.

Department of Tumor Immunology, Oncode Institute, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Biomaterial-based scaffolds are promising tools for controlled immunomodulation. They can be applied as three dimensional (3D) culture systems , whereas they may be used to dictate cellular localization and exert spatiotemporal control over cues presented to the immune system. As such, scaffolds can be exploited to enhance the efficacy of cancer immunotherapies such as adoptive T cell transfer, in which localization and persistence of tumor-specific T cells dictates treatment outcome. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):225-228

Department of Prosthodontics, Christian Dental College, Ludhiana, Punjab, India.

Squamous cell carcinoma (SCC) of the oral cavity is relatively common in the Indian subcontinent with surgical resection and adjuvant radiotherapy/chemotherapy being the treatment modality of choice. Prosthetic rehabilitation with an obturator following resection is more economical and yields satisfactory results. Better patient acceptance and comfort necessitates hollowing the prosthesis to a great extent. Read More