263,166 results match your criteria Indian journal of critical care medicine : peer-reviewed official publication of Indian Society of Critical Care Medicine[Journal]


Cultural Immersion Isn't About Diabetes: Understanding the Lakota Sioux Culture on the Pine Ridge Indian Reservation.

Authors:
Ali Haines

S D Med 2019 Mar;72(3):131-132

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

This article discusses the historical trauma and modern struggles of Oglala Lakota Sioux tribal members on the Pine Ridge Indian Reservation in southwestern South Dakota. In order for healthcare providers to understand why patients from this region have soaring rates of diabetes, teen pregnancies and premature death, it is important to have exposure to their culture and daily life. As part of their medical school curriculum, students at the Sanford School of Medicine take part in cultural immersion trips in order to better understand and relate to the people on the Pine Ridge Reservation. Read More

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American Indian Ethics of Health Care When Serving American Indian Patients in South Dakota.

S D Med 2019 Mar;72(3):123-126

Department of Neurosciences, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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The Patient As Team: American Indian Healthcare and the Transorganization - A Shout for Leadership.

S D Med 2019 Mar;72(3):114-118

Sanford Clinic - Infectious Disease, Sioux Falls, South Dakota.

American Indian health care in the state of South Dakota meets the definition of a humanitarian crisis and as such is being called a third-world country within its own borders. This dizzying challenge will require an out-ofthe-box but previously successful Transorganization, to address a problem which will never be solved by separate organizations operating in silos. It will also require visionary leadership to shine a permanent light on this conundrum, inviting all physicians and healthcare systems to join together as a team of teams, until this situation is transformed. Read More

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Comparative evaluation of cerebral gliomas using rCBV measurements during sequential acquisition of T1-perfusion and T2*-perfusion MRI.

PLoS One 2019 24;14(4):e0215400. Epub 2019 Apr 24.

Philips Health Tech Asia Pacific, Minato-ku Tokyo, Japan.

Objective: To assess the inter-technique agreement of relative cerebral blood volume (rCBV) measurements obtained using T1- and T2*-perfusion MRI on 3T scanner in glioma patients.

Methods: A total of 49 adult patients with gliomas underwent both on T1- and T2*-perfusion in the same scanning session, and rCBV maps were estimated using both methods. For the quantitative analysis; Two independent observers recorded the rCBV values from the tumor as well as contralateral brain tissue from both T1- and T2*-perfusion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215400PLOS

How conspicuous are peacock eyespots and other colorful feathers in the eyes of mammalian predators?

PLoS One 2019 24;14(4):e0210924. Epub 2019 Apr 24.

Migratory Bird Center, Smithsonian Conservation Biology Institute, National Zoological Park, Washington DC, United States of America.

Colorful feathers have long been assumed to be conspicuous to predators, and hence likely to incur costs due to enhanced predation risk. However, many mammals that prey on birds have dichromatic visual systems with only two types of color-sensitive visual receptors, rather than the three and four photoreceptors characteristic of humans and most birds, respectively. Here, we use a combination of multispectral imaging, reflectance spectroscopy, color vision modelling and visual texture analysis to compare the visual signals available to conspecifics and to mammalian predators from multicolored feathers from the Indian peacock (Pavo cristatus), as well as red and yellow parrot feathers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210924PLOS
April 2019
1 Read

Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin.

J Nat Prod 2019 Apr 24. Epub 2019 Apr 24.

Centre for Cellular and Molecular Biology , Hyderabad 500007 , India.

Two new resin glycosides, ipomeolides A (1) and B (2), both with an unusual nonlinear heteropentasaccharide core, along with five known compounds were isolated from the n-hexane/CHCl (1:1) extract of the aerial parts of Ipomoea pes-caprae. Ipomeolides A (1) and B (2) are macrolactone analogues of the rare (11 R)-jalapinolic acid, and macrolactonization occurred at C-2 of the second saccharide moiety. Compounds 1 and 2 show structural variation even in the pentasaccharide core. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01100DOI Listing

Room temperature phosphorescent triarylborane functionalized iridium complexes.

Dalton Trans 2019 Apr 24. Epub 2019 Apr 24.

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India.

We report a series of room temperature phosphorescent compounds 1-6 composed of triarylborane (TAB) and cyclometallated iridium complexes. The optical characteristics such as energy of transition and luminescence quantum yield of these compounds can be conveniently fine-tuned by judiciously varying the cyclometallating ligand and the spacer between boron and iridium centers. Compounds 1-6 exhibit bright phosphorescence with the emission color ranging from green to red under a N2 atmosphere. Read More

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http://dx.doi.org/10.1039/c9dt00590kDOI Listing

Implication of the whitefly, , collagen protein in begomoviruses acquisition and transmission.

Phytopathology 2019 Apr 24. Epub 2019 Apr 24.

University of Delhi, 28742, Gut Biology Laboratory, Room No. 117, Department of Zoology, Delhi, Delhi, India ;

Begomoviruses are the largest group of plant viruses, transmitted exclusively by the whitefly, (Gennadius) in a persistent, circulative and non-propagative manner. Begomoviruses, in association with cause enormous loss to world agricultural crops. Transmission, retention and circulation of begomovirus in are facilitated by its interaction with several proteins of the insect and its endosymbionts. Read More

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http://dx.doi.org/10.1094/PHYTO-03-18-0082-RDOI Listing

Spatial distribution of major bacterial species and different volatile fatty acids in a two-phase anaerobic biofilm reactor with PVA gel beads as bio-carrier.

Prep Biochem Biotechnol 2019 Apr 24:1-14. Epub 2019 Apr 24.

b Department of Civil Engineering , Indian Institute of Technology , Roorkee , India.

Conventional completely mixed anaerobic treatment systems limit the chances of the different species of bacteria to spatially group together according to their mutual cooperation and as a result, show a lower efficiency and vulnerability towards shock situations. It is interesting to know about the stratification of the different bacterial species participating in the degradation process and the intermediates that they produce. In this study, we established and optimized a two-phase anaerobic packed bed biofilm reactor system (AnPBR) with porous PVA gel beads used as bio-carriers and ran the reactor system in a steady state to observe the VFAs produced along with the microbial diversity of the predominant species at different stages of the reactor system. Read More

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http://dx.doi.org/10.1080/10826068.2019.1605525DOI Listing

Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds.

DNA Cell Biol 2019 Apr 24. Epub 2019 Apr 24.

1 Division of Biochemistry, ICAR-Indian Agricultural Research Institute, New Delhi, India.

Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we performed cytosine methylation analysis in the coding region of two isoforms and gene, in two contrasting soybean genotypes differing in total isoflavone content (NRC37: high isoflavone; and NRC7: low isoflavone). Read More

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http://dx.doi.org/10.1089/dna.2018.4584DOI Listing

Molecular dynamics investigation of a redox switch in the anti-HIV protein SAMHD1.

Proteins 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India, 400076.

HIV-1 is restricted in macrophages and certain quiescent myeloid cells due to a "Scorched Earth" dNTP starvation strategy attributed to the Sterile Alpha Motif and HD domain protein - SAMHD1. Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K of ~ 10 uM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells. Given the substantial disparity between the dNTP concentrations required to activate SAMHD1 tetramers (~10 uM) and the dNTP concentrations in noncycling cells (~10 nM), the possibility of alternate enzymatically active forms of SAMHD1, including monomers remains open. Read More

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http://dx.doi.org/10.1002/prot.25701DOI Listing

Ligand assisted electrocatalytic water oxidation by a copper(ii) complex in neutral phosphate buffer.

Chem Commun (Camb) 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry, B. Borooah College, Guwahati 781007, Assam, India.

The electrocatalytic water oxidation activity of a copper(ii) complex, 1, [Cu(L1H)(L1)(OH2)](ClO4), with a redox active aryl oxime ligand, L1H [L1H = 1-(pyridin-2-yl) ethanone oxime] has been investigated. Complex 1 shows a remarkably high turnover frequency of ∼100 s-1 in neutral phosphate buffer at about 675 mV overpotential with ∼94% faradaic efficiency. Electrochemical analysis suggests the involvement of a ligand moiety in a proton-coupled-electron-transfer (PCET) step during the catalytic cycle of complex 1, which in turn provides a route for accumulation of high oxidizing equivalents at the reaction center. Read More

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http://dx.doi.org/10.1039/c9cc00971jDOI Listing

Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations.

J Biomol Struct Dyn 2019 Apr 24:1-16. Epub 2019 Apr 24.

a Discipline of Biosciences and Biomedical Engineering , Indian Institute of Technology Indore , Indore , Madhya Pradesh , India.

The With-No-Lysine (WNK) kinase family plays a significant role in regulating cation-chloride cotransporters, blood pressure and body fluid homeostasis. Mutations in the gene of WNK family, especially in WNK1 and WNK4 are responsible for pseudohypoaldosteronism type II (PHAII), characterized by hypertension. The selective inhibition of WNK1 over other isoforms has created an immense challenge in the design of an ATP competitive inhibitor due to their high conservatism. Read More

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http://dx.doi.org/10.1080/07391102.2019.1602079DOI Listing

Differential expression of Ets-1 in breast cancer among North Indian population.

J Cell Biochem 2019 Apr 23. Epub 2019 Apr 23.

Division of Molecular Oncology and Head, Cellular & Molecular Diagnostics, National Institute of Cancer Prevention & Research, Indian Council of Medical Research, Noida, India.

Breast cancer is a highly aggressive disease contributing to high mortality rate among females across the globe owing to wide geographical variations, change in lifestyle along with rapid tumor growth, drug resistance, and high metastasis rate. To understand the molecular and genetic basis of breast cancer progression; we studied the role of E26 transformation-specific-1 (Ets-1) transcription factor which is implicated to have a role in carcinogenesis like invasion, metastasis, angiogenesis, etc. Our findings revealed an overexpression of Ets-1 gene in 75 breast cancer tumors as compared with their normal adjacent tissues. Read More

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http://dx.doi.org/10.1002/jcb.28716DOI Listing

Synthesis of Nucleobase-Functionalized Morpholino Monomers.

Methods Mol Biol 2019 ;1973:107-130

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India.

Morpholino antisense oligonucleotides are used as routine tools in developmental biology to investigate gene function during early embryogenesis. These chemically modified oligos contain morpholine ring connected with phosphorodiamidate linkages as backbone but carry unmodified nucleobases. In this chapter, we describe the methods to further modify the nucleobases using palladium-catalyzed cross-coupling reactions. Read More

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http://dx.doi.org/10.1007/978-1-4939-9216-4_7DOI Listing
January 2019

Lentiviral-mediated delivery of classical swine fever virus Erns gene into porcine kidney-15 cells for production of recombinant ELISA diagnostic antigen.

Mol Biol Rep 2019 Apr 23. Epub 2019 Apr 23.

Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India.

Classical swine fever virus (CSFV), a member of the Pestivirus genus within the Flaviviridae family causes contagious fatal disease in swine. Antibodies against E2, Erns and NS3 proteins of virus can be detected in infected animals. Development of an ELISA coating antigen to improve the sensitivity of detecting Erns-specific antibodies in pig sera is always desirable for diagnosis as well as for differentiation of infected from vaccinated animals. Read More

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http://dx.doi.org/10.1007/s11033-019-04829-0DOI Listing

Enhanced high rate capability of Li intercalation in planar and edge defect-rich MoS nanosheets.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Multifunctional Materials Laboratory, Department of Physics, Indian Institute of Technology Madras, Chennai 600036, India.

(i) Edge and planar defect-rich and (ii) defect-suppressed MoS2 nanosheets are fabricated by controlled annealing of wet-chemically processed precursors. Wrinkles, folds, bends, and tears lead to the introduction of severe defects in MoS2 nanosheets. These defects are suppressed and highly crystalline MoS2 nanosheets are obtained upon high-temperature annealing. Read More

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http://dx.doi.org/10.1039/c9nr02043hDOI Listing

Reporting cell planning-based cellular mobility management using a Binary Artificial Bat algorithm.

Heliyon 2019 Mar 7;5(3):e01276. Epub 2019 Mar 7.

Indian Institute of Technology, Kharagpur, India.

This paper attempts to present a novel application of Binary Artificial Bat algorithm for more effective location management in cellular networks. The location management is a mobility management task, which involves tracking of the mobile stations to locate their exact positions so that an incoming call or data can be routed to the intended mobile user. The location management cost comprises of the costs incurred by two processes, namely location registration and location search. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183601
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http://dx.doi.org/10.1016/j.heliyon.2019.e01276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475638PMC
March 2019
1 Read

Could the Glycemic Gap Fill the Unfilled Gaps?

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):171

Department of Translational Medicine, Pneumology Unit U, Università del Piemonte Orientale, PO Sant'Andrea, Vercelli, Italy.

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http://dx.doi.org/10.4103/ijem.IJEM_617_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446665PMC

Low Bone Mass and Klinefelter Syndrome.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):167-168

Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijem.IJEM_486_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446686PMC

Juvenile Autoimmune Hypothyroidism and Gender Dysphoria: A Causal Relationship or A Casual Coincidence?

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):166-167

Department of Endocrinology, Dr. M. Manoj Endocrinology Clinic, Warangal, Telangana, India.

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http://dx.doi.org/10.4103/ijem.IJEM_656_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446668PMC

Fournier's Gangrene and Sodium-glucose Co-transporter 2(SGLT2) Inhibitors: Our Experience.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):165-166

Department of Endocrinology and Diabetes, Manipal Hospital, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/ijem.IJEM_614_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446678PMC

Endocrine Manifestations of Von Hippel-Landau Disease.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):159-164

Department of Endocrinology, SGPGIMS, Lucknow, Uttar Pradesh, India.

Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder characterized by various endocrine, nonendocrine, benign, and malignant tumors in various organs. VHL tumor suppressor gene, located on short arm of chromosome 3 is responsible for this. Pheochromocytoma (PCC) is one of the important endocrine manifestations that needs to be ruled out in case of VHL suspicion. Read More

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http://www.ijem.in/text.asp?2019/23/1/159/254446
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http://dx.doi.org/10.4103/ijem.IJEM_252_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446673PMC
April 2019
1 Read

Cardiovascular Effects of Sodium Glucose Co-transporter-2 Inhibitors in Patients with Type 2 Diabetes Mellitus.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):150-158

Department Endocrinology, NRS Medical College, Kolkata, West Bengal, India.

Type 2 diabetes mellitus (T2DM), the leading type of diabetes, has a typical association with coronary heart disease. In India, patients with diabetes are at an increased risk of developing coronary disease as compared to people without diabetes and this suggests the requirement of intensive treatment of cardiovascular (CV) risk factors. Consequently, there is a need for an intervention that could target CV risk factors in multiple paths beyond hyperglycemic control alone. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_161_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446691PMC

Sodium Glucose Co-transporter-2 Inhibitor: Benefits beyond Glycemic Control.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):140-149

Department of Medical Affairs, AstraZeneca Pharma India Limited, Bengaluru, Karnataka, India.

Type 2 diabetes mellitus (T2DM) is a family of metabolic disorders characterized by hyperglycemia as a consequence of abnormalities in insulin secretion and insulin sensitivity. It affects hundreds of millions of people worldwide and leads to increased morbidity, compromised quality of life, higher mortality sodium glucose co-transporter 2 (SGLT2) inhibitors, a new class of oral antidiabetic drugs, have garnered considerable attention in the recent past and are considered potential first-line candidates for the management of T2DM. This review outlines the evidence-based therapeutic efficacy, safety, limitations, and advantages of SGLT2 inhibitors in the management of T2DM. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_160_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446679PMC

Uric Acid and Its Correlation with Various Metabolic Parameters: A Population-Based Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):134-139

Department of Endocrinology, IPGME and R, Kolkata, West Bengal, India.

Introduction: Uric acid, apparently an inert waste product, was found to have association with various metabolic disorders. The data regarding prevalence of serum uric acid (SUA) abnormalities and its correlation with other anthropo-metabolic parameters, however, are scanty.

Materials And Methods: In all, 405 participants from a rural area were investigated for various metabolic parameters including uric acid. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_18_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446663PMC

Heart Failure Hospitalization with DPP-4 Inhibitors: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):128-133

Department of Gynecology and Obstetrics, G.D Hospital and Diabetes Institute, Kolkata, West Bengal, India.

Background: Heart failure hospitalization (hHF) with dipeptyl-dipeptidase-4 inhibitors (DPP-4Is) remains at the center stage since the publication of Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus - Thrombolysis in Myocardial Infarction (SAVOR-TIMI) in 2013 showing significant increase with saxagliptin, compared to placebo. This outcome led to additional label of hHF to both saxagliptin and alogliptin in April 2016 and eventual labelling of hHF to all the four approved DPP-4Is in United States in August 2017, by US Food Drug Administration. To note, neither Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), nor Cardiovascular and Renal Microvascular Outcome Study with Linagliptin (CARMELINA), showed any signals of hHF with these two agents. Read More

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http://www.ijem.in/text.asp?2019/23/1/128/254459
Publisher Site
http://dx.doi.org/10.4103/ijem.IJEM_613_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446681PMC
April 2019
3 Reads

Role of Procalcitonin as a Predictor of Clinical Outcome in Acute Diabetic Foot Infections: A Prospective Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):122-127

Department of Endocrinology and Podiatry, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Background: Prediction of outcome in diabetic foot infection (DFI) remains difficult due to lack of active signs of infection, and apparently normal white blood cell (WBC) count. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been studied previously in this regard and were not useful. Hence, we evaluated procalcitonin (PCT) as a prognostic marker in this study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_525_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446684PMC

Response to Zoledronic Acid in Patients with Active Paget's Disease of Bone: A Retrospective Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):117-121

Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Gorimedu, Puducherry, India.

Background: Traditionally, bisphosphonates are used to treat active Paget's disease of bone (PDB). Intravenous zoledronic acid (ZA) is the most effective treatment option leading to sustained remission.

Objective: The primary objective of this study was to analyze the effect of intravenous ZA in patients with active PDB in a tertiary care center of India. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_327_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446674PMC
April 2019
1 Read

Polymorphic Analysis of Leptin Promoter in Obese/diabetic Subjects in Kashmiri Population.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):111-116

Department of Biotechnology, University of Kashmir, Hazratbal Srinagar, Srinagar, Jammu and Kashmir, India.

Background: The role of common variants in leptin promoter has already been established to play a major role in obesity and diabetes in humans. The study was accordingly focused on leptin promoter variants and their potential association with diabetes and obesity in ethnic population from Kashmir, India.

Methods: Allele frequencies of 620 Kashmiri subjects with diabetes (200), obese subjects (200), and ethnically matched healthy controls (200) were tested for the Hardy-Weinberg disequilibrium. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_164_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446689PMC

Development and Validation of a Questionnaire Assessing Knowledge, Attitude, and Practices about Obesity among Obese Individuals.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):102-110

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Aim: The objective of this study was to develop and validate a knowledge, attitude, and practice (KAP) questionnaire about obesity among obese individuals.

Materials And Methods: The questionnaire was developed following a standardized protocol that consisted of literature review, focused group discussions, and expert opinion. A cross-sectional survey on 100 obese individuals was carried out to validate the tool. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_487_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446687PMC

Utility of a Commercially Available Blood Steroid Profile in Endocrine Practice.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):97-101

Department of Endocrinology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.

Background: A blood steroid profile has recently become available on commercial basis in India. In this study, we report our initial experience with the use of steroid profile in the evaluation of disorders of sex development (DSD) and suspected cases of congenital adrenal hyperplasia (CAH) and discuss the potential scenarios in endocrine practice that may benefit from this steroid profile.

Materials And Methods: The study included six subjects. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_531_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446682PMC

Impact of Anemia and Red Cell Indices on the Diagnosis of Pre-Diabetes and Diabetes in Indian Adult Population: Is there a Cut-off Guide for Clinicians?

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):91-96

Department of Endocrinology, Diabetes and Metabolism, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, Karnataka, India.

Background: It is well known that anemia and red cell turn over affects the HbA1c value. Iron deficiency anemia increases the HbA1c and haemolytic anemia lowers it. However, the cut-off of haemoglobin (Hb) or red-cell indices when the HbA1c value becomes unreliable is not known. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_190_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446692PMC

Risk Assessment of Diabetes Using the Indian Diabetes Risk Score: A Study on Young Medical Students from Northern India.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):86-90

Department of Community Medicine, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.

Context: Identification of risk factors of diabetes is required among youth as diabetes in young persons is now spreading in epidemic proportions. Indian Diabetes Risk Score (IDRS) is a validated and cost- effective tool to identify risk of diabetes among population.

Aims: Present study was conducted among young medical students to assess risk of type 2 diabetes mellitus (T2DM) using the IDRS and to study association of risk of diabetes with other factors. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_623_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446666PMC

Vitamin D Status of School Children in and around Guwahati.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):81-85

Department of Endocrinology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

Context: Peripubertal and adolescent children are vulnerable to vitamin D deficiency as this is the period of rapid skeletal growth.

Aims: This study was done to assess the vitamin D status in school children between the age of 8-14 years attending the government schools in rural and urban areas of Assam in Northeast India.

Settings And Design: This was a cross-sectional observational study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_552_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446688PMC

Safety and Efficacy of Bipolar Radiofrequency Ablation Device in Hemostasis during Thyroidectomy in Comparison with Ultrasonic Scalpel: A Comparative Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):76-80

The Specialized Endocrine and Diabetes Center, Al-Mawani Teaching Hospital, Basra, Iraq.

Aim: Ultrasonic scalpel is one of the recent advances in surgical technology. The main limitation of their use is the cost. However, radiofrequency ablation device is a refined type of electrosurgical cautery that can be used with conventional reusable bipolar cautery forceps. Read More

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http://www.ijem.in/text.asp?2019/23/1/76/254452
Publisher Site
http://dx.doi.org/10.4103/ijem.IJEM_519_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446675PMC
April 2019
1 Read

The Effect of a High-intensity Interval Training on Plasma Vitamin D Level in Obese Male Adolescents.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):72-75

Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The worldwide increasing vitamin D deficiency in adolescents is alarming. The effect of high-intensity trainings on adolescent health is not clear.

Object: This study aimed to examine the effect of a high-intensity interval training (HIIT) on plasma level of vitamin D in overweight male adolescents. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_267_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446690PMC

Focused Parathyroidectomy Under Local Anesthesia - A Feasibility Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):67-71

Department of Endocrine Surgery, CMC Hospital, Vellore, Tamil Nadu, India.

Purpose: We conducted this study to evaluate the feasibility, patient satisfaction, and cost of performing focused parathyroidectomy under local anesthesia (LA) and mild sedation, administered and monitored by a surgeon.

Materials And Methods: This was a prospective observational study of 30 patients with primary hyperparathyroidism (PHPT) undergoing a focused parathyroidectomy under LA and mild sedation at a single institution. The clinical features, gland weight, operating time, procedure time, postoperative pain scores, overall patient satisfaction, postoperative nausea and vomiting, analgesic requirements, complications, cost, and cure rates were documented. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_590_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446694PMC

Sex Hormone Levels - Estradiol, Testosterone, and Sex Hormone Binding Globulin as a Risk Marker for Atherosclerotic Coronary Artery Disease in Post-menopausal Women.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):60-66

Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India.

Context: Sex hormones levels determine the risk of occurrence of coronary artery disease (CAD) in post-menopausal (PM) women.

Aims: To investigate the relationship between sex hormones (estradiol and testosterone)/sex hormone binding globulin (SHBG) and cardiovascular risk factors in PM women. In addition, we learned the association between these sex hormones/SHBG and the occurrence of atherosclerotic CAD event in PM women. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_505_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446685PMC

Prolactin-adjusted ACTH Ratio in Predicting Lateralization of ACTH Source During Simultaneous Bilateral Inferior Petrosal Sinus Sampling in Patients with Cushing's Disease.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):56-59

Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Prolactin-adjusted adrenocorticotropic hormone (ACTH) ratio is used to improve the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) for lateralization of pituitary adenoma.

Objective: To study the use of prolactin for successful catheterization during BIPSS, the role of prolactin-normalized ACTH ratio for confirmation of Cushing's disease (CD) and prolactin-adjusted ACTH ratio in predicting the lateralization.

Patients And Methods: BIPSS was done in patients with CD; prolactin-adjusted ACTH ratio was compared with intersinus ACTH ratio, magnetic resonance imaging, and intraoperative findings for localization of pituitary adenoma. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_486_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446680PMC
April 2019
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Adverse Effect Profile and Effectiveness of Sodium Glucose Co-transporter 2 Inhibitors (SGLT2i) - A Prospective Real-world Setting Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):50-55

Division of Endocrinology and Diabetes, Medanta The Medicity, Gurugram, Haryana, India.

Background: Clinical trials have shown promising results in terms of glycemic control and weight reduction with the use of sodium glucose co-transporter 2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2DM). However, real-world evidence from standard clinical practice especially from Asia is still limited. The aim of this study was to evaluate the safety and effectiveness of SGLT2i in patients with T2DM in real-world setting. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_566_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446693PMC

A Comparison between Silent and Symptomatic Renal Stones in Primary Hyperparathyroidism.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):46-49

Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.

Background: Nephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and in a subgroup of patients stones are clinically silent. Patients with silent and symptomatic stones may differ biochemically. There is a scarcity of data available comparing patients with silent and symptomatic renal stones in PHPT. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_558_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446667PMC

Drug Prescription Patterns and Cost Analysis of Diabetes Therapy in India: Audit of an Endocrine Practice.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):40-45

Department of Endocrinology, BRIDE, Karnal, Haryana, India.

Aims: The aim of this study was to analyze the current trend in the use of antidiabetes as well as other drugs for comorbidities along the duration of diabetes. The study also aimed to analyze the direct drug cost to patients.

Settings And Design: Retrospective cross-sectional study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_646_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446683PMC

Evaluation of Vitamin D Status and its Impact on Thyroid Related Parameters in New Onset Graves' Disease- A Cross-sectional Observational Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):35-39

Department of Endocrinology, S.C.B Medical College, Cuttack, Odisha, India.

Aims And Objective: We aimed to compare serum vitamin D level in new onset Graves' disease versus age and sex matched controls. Furthermore, we assessed the correlation of vitamin D with hormonal parameters and antibody titers in Graves' disease.

Materials And Methods: In total, 84 patients of new onset Graves' disease and 42 age and sex matched healthy individuals were recruited. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_183_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446662PMC

Effect of Vitamin D Supplementation on Bone Turnover Markers in Children and Adolescents from North India.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):27-34

Department of Medicine, Dr. B R Sur Homeopathic Medical College, New Delhi, India.

Objectives: Vitamin D is known to play an important role in bone mineral metabolism. Its deficiency may affect growth and status of bone markers in children. Hence, we undertook to study the status of bone markers in children with vitamin D deficiency (VDD) and impact of vitamin D3 supplementation on them. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_149_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446672PMC

Coexistence of Autoimmune Disorders and Type 1 Diabetes Mellitus in Children: An Observation from Western Part of India.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):22-26

Department of Endocrinology, SMS Medical College and Hospitals, JLN Road, Jaipur, Rajasthan, India.

Introduction: Type 1 diabetes mellitus (T1DM) is associated with various autoimmune disorders like celiac disease, thyroid disorder, adrenal failure, etc. However, how common is this association in Indian children is not clearly known.

Objective: To assess the prevalence of other coexisting autoimmune disorders in children with T1DM. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_103_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446677PMC

Evaluation of Changes in Insulin Sensitivity in Prepubertal Small for Gestational Age Children Treated with Growth Hormone.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):14-21

Department of Pediatric Endocrinology, Dr. von Haunersches Children's Hospital, Ludwig-Maximilian-University of Munich, Lindwurmstr, Munich, Germany.

Background: Although growth hormone (GH) therapy for children born small for gestational age (SGA) has been approved for many years, there are still concerns about increasing their risk for insulin resistance and diabetes mellitus type 2. Monitoring of glucose homeostasis is therefore generally recommended, but there is no consensus on either the methods or consequences.

Methods And Aims: The aim of our study was to analyze the oral Glucose Tolerance Tests (oGTTs) which were performed yearly from baseline to 4 years of GH therapy in a collective of 93 SGA children, who were prepubertal during the whole follow-up. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_91_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446669PMC

High Prevalence of Genital Mycotic Infections with Sodium-glucose Co-transporter 2 Inhibitors among Indian Patients with Type 2 Diabetes.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):9-13

Department of Endocrinology, Dr. Khanna's Endocrinology Clinic, Amritsar, Punjab, India.

Introduction: Genital mycotic infections are common among patients with poorly controlled diabetes. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) induced pharmacological glycosuria increases the risk of these infections (2-3 fold) among patients with type 2 diabetes (T2D). The data about incidence of these infections in Indian setting is unclear. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_244_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446664PMC

Stretched Penile Length and Testicular Size from Birth to 18 Years in Boys from Western Maharashtra.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):3-8

Department of Growth and Pediatric Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.

Background: Genital stage and testicular volume examination and assessment are essential for assessment of growth puberty in boys. There is paucity of Indian data for penile and testicular parameters particularly in pubertal years.

Aim: The aim of this study is to present normative data for penile length, testicular volume, and testicular length from birth to 18 years in boys from western Maharashtra and to correlate these parameters with sexual maturity staging (SMR) (Tanner staging). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_242_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446671PMC