262,951 results match your criteria Indian Journal of Science and Technology [Journal]


Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.

Cytokine 2019 Apr 16;120:28-40. Epub 2019 Apr 16.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Viperin is an interferon-inducible protein that helps in protecting mammals against various virus infections. Viperin is a highly conserved member of the interferon-stimulated genes (ISG) family in many species. Viperin has been shown to play a pivotal role in the innate immunity of chicken; however, its role has not been explored in its antiviral potential. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.007DOI Listing

Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters.

Comput Biol Med 2019 Mar 12;108:31-41. Epub 2019 Mar 12.

Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India. Electronic address:

Patients having a medical history of oral cancer, infectious diseases or trauma are often advised surgical intervention with customized complete mandibular constructs (CMC) made of Titanium (Ti) scaffolds. A numerical framework based on a homogenization technique was developed to investigate the influence of pore architecture parameters on homogenized orthotropic material properties of the scaffolds. A comparative 3D Finite Element (FE) analysis of six CMC models, having homogenized orthotropic material properties, under a mastication cycle, was undertaken to pre-clinically determine the optimal CMC for a patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193007
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.004DOI Listing
March 2019
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Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
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Effect of selective serotonin reuptake inhibitors on markers of bone loss.

Psychiatry Res 2019 Apr 3;276:39-44. Epub 2019 Apr 3.

Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Several preclinical and clinical studies show that selective serotonin reuptake inhibitors (SSRI's) are associated with bone loss and an increase in fracture risk, not many reports on their effect on bone turnover markers. This cross-sectional study evaluated the effect of SSRIs treatment on bone turnover markers in Indian population for the first time. Inclusion criteria were subjects of either sex and age 18-45 years undergoing treatment with an SSRI for at least 3 months, regardless of the indication. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.04.006DOI Listing

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 16. Epub 2019 Apr 16.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically over the last few decades. Recent reports from the World Health Organization advocate that overall global cancer burden and deaths due to cancer are expected to double by the next decade. Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019
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Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: Phylogenetic characteristics of circulating Indian dengue viruses (DENV) were analysed using partial pre-membrane (PrM) and envelope (E) sequences. An immunodominant region was analysed for mutations and alignment with common DENV PCR primers and probes was determined.

Methods: Published Indian PrM and E DENV sequences were analysed with hitherto unpublished PrM sequences from this study site. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.010DOI Listing

Comparative study of keratin extraction from human hair.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India. Electronic address:

Keratin has been attracting interest due to its stability against enzymatic degradation thereby allowing more predictable degradation profile for tissue regeneration. While the efficacy of keratin has been demonstrated in different tissue models, there has been no systematic study to investigate and compare the different routes of keratin extraction from human hair. Here, we compared the four commonly used extraction methods and highlight the both physical and chemical differences in the extracted keratin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183122
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.098DOI Listing
April 2019
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Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India. Electronic address:

Chitosan, a natural biopolymer with osteoconductive properties is widely investigated to generate scaffolds for bone tissue engineering applications. However, chitosan based scaffolds lacks in mechanical strength and structural stability in hydrated condition and thereby limits its application for bone tissue regeneration. Thus in the present study, to overcome the limitations associated with chitosan based scaffolds, we fabricated polyelectrolyte complexation mediated composite scaffold of chitosan and chondroitin sulfate incorporated with nano-sized bioglass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183730
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.107DOI Listing
April 2019
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Presence of actin binding motif in VgrG-1 toxin of Vibrio cholerae reveals the molecular mechanism of actin cross-linking.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, Nadia, West Bengal, India. Electronic address:

Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 bacteriophage. VgrG-1 of V. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.026DOI Listing

Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.

Biochim Biophys Acta Biomembr 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

Lipid structure critically dictates the molecular interactions of drugs with membranes influencing passive diffusion, drug partitioning and accumulation, thereby underpinning a lipid-composition specific interplay. Spurring selective passive drug diffusion and uptake through membranes is an obvious solution to combat growing antibiotic resistance with minimized toxicities. However, the spectrum of complex mycobacterial lipids and lack thereof of suitable membrane platforms limits the understanding of mechanisms underlying drug-membrane interactions in tuberculosis. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.04.004DOI Listing

Activated red mud as a permeable reactive barrier material for fluoride removal from groundwater: Parameter optimization and physico-chemical characterization.

Environ Technol 2019 Apr 19:1-39. Epub 2019 Apr 19.

a Department of Chemical Engineering , GMR Institute of Technology , Rajam 532 127 , Srikakulam , India.

The main aim of this work is to test the performance of red mud as a permeable reactive barrier (PRB) material for fluoride removal from water. Batch experiments were carried out to optimize the fluoride removal efficiency (RE) of activated red mud (ARM) based on four selected parameters, namely, the initial fluoride concentration (3-40 mg/L), adsorbent dose (0.5-5 g/L), pH (3. Read More

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http://dx.doi.org/10.1080/09593330.2019.1609591DOI Listing

Synthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2-Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids.

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Natural Product Chemistry Division , Indian Institute of Integrative Medicine (IIIM) , Jammu 180001 , India.

Pd-catalyzed carbonylative cross-coupling reactions of 2-iodoglycals have been developed for the synthesis of sugar-based arylones and ynones using formic acid as the carbonyl source. Whereas acetyl-protected arylones lead to the formation of highly substituted furan derivatives in the presence of Lewis acid, benzyl-protected arylones furnished the 3-deoxy sugar derivative. In the presence of nucleophiles, an attack took place on the C-1 or C-3 carbon regio- and stereoselectively depending on the nature of the nucleophiles. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00680DOI Listing

Similarities in mRNA expression of peripheral blood drug metabolizing enzymes and cancer marker genes with biopsy samples of head and neck cancer patients.

Biomarkers 2019 Apr 19:1-30. Epub 2019 Apr 19.

a Developmental Toxicology Laboratory, System Toxicology & Health Risk Assessment Group , CSIR-Indian Institute of Toxicology Research (CSIR-IITR) , Vishvigyan Bhawan, 31, Mahatma Gandhi Marg , Lucknow - 226001 , U.P , India.

Purpose: To develop peripheral blood mRNA expression profiles of drug metabolizing enzymes (DMEs) as a surrogate to monitor tobacco induced head & neck squamous cell carcinoma (HNSCC), attempts were made to investigate i) similarities in alterations with the cancer marker genes in biopsy samples, and ii) if alterations similar to that seen in biopsy samples are reflected in peripheral blood.

Methods: Total RNA from eight soft gingival tissues and eight biopsy samples of HNSCC patients and total DNA and RNA from blood of healthy controls (n = 150) and HNSCC patients (n = 150) was processed for expression and genotyping studies. Blood from patients receiving chemo-radiotherapy was processed for follow-up study Results: qRT-PCR revealed significant increase in mRNA expression of DMEs in biopsy and blood samples of HNSCC patients when compared to controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1
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http://dx.doi.org/10.1080/1354750X.2019.1609090DOI Listing
April 2019
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Oceanographic barriers, divergence, and admixture: Phylogeography and taxonomy of two putative subspecies of short-finned pilot whale.

Mol Ecol 2019 Apr 19. Epub 2019 Apr 19.

Southwest Fisheries Science Center, National Marine Fisheries Service, NOAA, 8901 La Jolla Shores Drive, La Jolla, CA, 92037.

Genomic phylogeography plays an important role in describing evolutionary processes and their geographic, ecological, or cultural drivers. These drivers are often poorly understood in marine environments, which have fewer obvious barriers to mixing than terrestrial environments. Taxonomic uncertainty of some taxa (e. Read More

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http://dx.doi.org/10.1111/mec.15107DOI Listing

Mixed Mycobacterium tuberculosis Lineage Infection in 2 Elephants, Nepal.

Emerg Infect Dis 2019 May;25(5):1031-1032

Tuberculosis in elephants is primarily caused by Mycobacterium tuberculosis. We identified mixed M. tuberculosis lineage infection in 2 captive elephants in Nepal by using spoligotyping and large sequence polymorphism. Read More

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http://dx.doi.org/10.3201/eid2505.181898DOI Listing

Metal-Free Directed Diastereoselective C2,C3-Cyclopropanation of Substituted Indoles with Diazoesters.

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Department of Chemistry , Indian Institute of Technology Madras , Chennai 600036 , India.

A metal-free directed C2,C3-cyclopropanation of suitably substituted indoles with α-diazo esters has been accomplished for the diastereoselective synthesis of cyclopropane-fused indolines in good yield. This method works well with a wide range of differently substituted α-diazo esters as well as indole derivatives and shown excellent compatibility for diverse directing group like pyridyl, pyrimidyl, acyl, and urea derivatives. Furthermore, the preliminary mechanistic investigation revealed the importance of directing group for the developed transformation. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01197DOI Listing

Mercury detoxification by absorption, mercuric ion reductase, and exopolysaccharides: a comprehensive study.

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Applied Microbiology, Department of Environmental Science & Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, 826 004, India.

Mercury (Hg), the environmental toxicant, is present in the soil, water, and air as it is substantially distributed throughout the environment. Being extremely toxic even at low concentration, its remediation is utterly important. Therefore, it is necessary to detoxify the contaminant within the acceptable limits before threatening the environment. Read More

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http://dx.doi.org/10.1007/s11356-019-04974-wDOI Listing

Mimivirus encodes a multifunctional primase with DNA/RNA polymerase, terminal transferase and translesion synthesis activities.

Nucleic Acids Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra 400076, India.

Acanthamoeba polyphaga mimivirus is an amoeba-infecting giant virus with over 1000 genes including several involved in DNA replication and repair. Here, we report the biochemical characterization of gene product 577 (gp577), a hypothetical protein (product of L537 gene) encoded by mimivirus. Sequence analysis and phylogeny suggested gp577 to be a primase-polymerase (PrimPol)-the first PrimPol to be identified in a nucleocytoplasmic large DNA virus (NCLDV). Read More

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http://dx.doi.org/10.1093/nar/gkz236DOI Listing

Synthesis of a 3,4-Disubstituted 1,8-Naphthalimide-Based DNA Intercalator for Direct Imaging of .

ACS Omega 2019 Mar 26;4(3):5829-5838. Epub 2019 Mar 26.

Laboratory for Quantum Semiconductors and Photon-Based BioNanotechnology, Interdisciplinary Institute for Technological Innovation (3IT), CNRS UMI-3463, Department of Electrical and Computer Engineering, Université de Sherbrooke, Sherbrooke, Québec J1K 0A5, Canada.

The development of organic molecules to target nucleic acid is an active area of research at the interface of chemistry and biochemistry, which involves DNA binding, nuclear imaging, and antitumor studies. These molecules bind with DNA through covalent interactions, electrostatic interactions, or intercalation. However, they are less permeable to membrane, and they have a significant cytotoxicity, which limits their application under in vivo conditions. Read More

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http://dx.doi.org/10.1021/acsomega.8b03638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463538PMC

NF-κB Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation.

Front Immunol 2019 2;10:667. Epub 2019 Apr 2.

Center of Excellence in Epigenetics, Indian Institute of Science Education and Research, Pune, India.

SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4 T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of T cells. Although SATB1 function has been subjected to intense investigation, regulation of gene expression remains poorly understood. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454056PMC

Appraisal of Core Therapy, Supportive Therapy, and Alternative Therapy in a Tertiary Care Rural Hospital of Vidarbha Region in Correlation to Plethora of Menopausal Problems.

J Midlife Health 2019 Jan-Mar;10(1):14-21

OBGY, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.

Context: Menopause is a crucial phase of the women fraternity which marks the end of reproductive age. Mostly it is physiological; however, certain conditions may lead to premature menopause. Menopause has an extensive spectrum of symptoms which are extremely bothersome. Read More

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http://dx.doi.org/10.4103/jmh.JMH_131_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459068PMC

Presidential speech: President, Indian Menopause Society 2019.

Authors:
Neelam Aggarwal

J Midlife Health 2019 Jan-Mar;10(1):1-2

Professor, Department of Obs Gynae, PGIMER, Chandigarh, Punjab, India. E-mail:

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http://www.jmidlifehealth.org/text.asp?2019/10/1/1/255294
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http://dx.doi.org/10.4103/0976-7800.255294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459063PMC
April 2019
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Symptomatic Extracranial Carotid Artery Thrombus: An Indian Experience.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):312-315

Division of Stroke and Interventional Neurology and Department of Neurology, NH Institute of Neurosciences, Narayana Health City, Bengaluru, Karnataka, India.

Introduction: Symptomatic intraluminal carotid artery thrombus (ICT) is an uncommon finding, whose incidence increases with the percentage of stenosis. The optimal treatment modality to address carotid artery thrombus is not well established. We present our data of medical management of carotid artery thrombus with antiplatelet and anticoagulation. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/312/254
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http://dx.doi.org/10.4103/jnrp.jnrp_225_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454977PMC
April 2019
1 Read

Study of Frontal Alpha Asymmetry in Mild Depression: A Potential Biomarker or Not?

J Neurosci Rural Pract 2019 Apr-Jun;10(2):250-255

Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.

Background: Depression, despite being the most common of mental illness lacks any quantifiable and absolute biomarker. Frontal alpha asymmetry (FAA) is proposed as biomarker of depression both in resting and activated state. Yet, the location of extraction of alpha, clinical utility as well as validity of FAA is uncertain. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/250/254
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http://dx.doi.org/10.4103/jnrp.jnrp_293_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454961PMC
April 2019
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Pattern of Emergent Head Computed Tomography Findings in a Tertiary Care Hospital during off Working Hours: Retrospective Analysis.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):207-211

Department of Radiodiagnosis, Indian Naval Hospital Ship Asvini, Mumbai, Maharashtra, India.

Introduction: Emergency head computed tomography (CT) is rising exponentially during off working hours due to evidence-based medicine, patient's expectation and desires, easy availability and apprehension of medico-legal cases, thereby raising health-care cost. There is huge gap in demand and supply of radiologist, especially during off working hours. There is need to know the pattern of emergency head findings. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/207/254
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http://dx.doi.org/10.4103/jnrp.jnrp_362_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454959PMC
April 2019
1 Read

Lumbar rocking test: A new clinical test for predicting lumbar instability.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):33-38

Department of Orthopaedics, LTMMC and Sion Hospital, Mumbai, Maharashtra, India.

Purpose: Significant number of low back pain is caused by spinal instability. Clinical and radiological tests are used to diagnose lumbar instability, but the practical utility of clinical tests has not been studied extensively. Hence, it was decided to study lumbar rocking test and passive lumbar extension (PLE) clinical tests to identify their accuracy for lumbar instability, in comparison to the radiological assessment. Read More

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http://www.jcvjs.com/text.asp?2019/10/1/33/255730
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http://dx.doi.org/10.4103/jcvjs.JCVJS_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469328PMC
April 2019
1 Read

Volumetric and Morphometric Analysis of Pineal and Pituitary Glands of an Indian Inedial Subject.

Ann Neurosci 2018 Dec 14;25(4):279-288. Epub 2019 Jan 14.

Biomedical Engineering Group, Department of Applied Mechanics, IIT Madras, Chennai, India.

Background: Inedia (Latin for "fasting") is the ability of a person to live without consuming food and water and to sustain solely by prana, the vital life force in Hinduism. According to Ayurveda, sunlight is one of the main sources of prana, and some practitioners believe that it is possible for a person to survive on sunlight alone.

Purpose: In this study, we report the unusual sizes and volumes of both the pineal and pituitary glands in a subject with inedia state for nearly 70 years. Read More

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http://dx.doi.org/10.1159/000487067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470330PMC
December 2018

Changes in MIDAS, Perceived Stress, Frontalis Muscle Activity and Non-Steroidal Anti-Inflammatory Drugs Usage in Patients with Migraine Headache without Aura following Ayurveda and Yoga Compared to Controls: An Open Labeled Non-Randomized Study.

Ann Neurosci 2018 Dec 11;25(4):250-260. Epub 2018 Sep 11.

Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA) A Deemed to be University, Bengaluru, India.

Background: There has been a significant increase in the use of complementary and integrative medicine to provide long-term healing solutions in migraine headache patients. Knowing the limitations of conventional medical approach, the present study evaluated the influence of two Indian traditional systems of medicine on migraine-related disability, autonomic variables, perceived stress, and muscle activity in patients with migraine headache without aura.

Methods: Thirty subjects recruited to the Ayurveda and Yoga (AY) group underwent traditional (Bio-purification) using therapeutic Purgation followed by yoga therapy, while 30 subjects of control (CT) group continued on symptomatic treatment (non-steroidal anti-inflammatory drugs [NSAID's]) for 90 days. Read More

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http://dx.doi.org/10.1159/000492269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470355PMC
December 2018

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study.

Ann Neurosci 2018 Dec 25;25(4):219-222. Epub 2018 Jul 25.

Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Background: Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading to economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 populations. Read More

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http://dx.doi.org/10.1159/000487066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470354PMC
December 2018

Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence.

Ann Neurosci 2018 Dec 5;25(4):201-209. Epub 2018 Jul 5.

DBT-AIST International laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.

Background: Natural extracts and compounds used in traditional home medicine are known for their safety and a variety of health promoting and therapeutic potentials. In contrast to the single molecule mediated targets, the combinational therapies are preferred for their multi-functional and limited toxic regimens and may be useful for disease therapeutics as well as to increase the quality of life during a variety of environmental stresses.

Purpose: We aimed to combine the active ingredients of Chinese () and Indian () ginsengs to develop a natural, efficient, and welfare combinatorial mixture with high anti-stress and glial differentiation potentials. Read More

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https://www.karger.com/Article/FullText/490693
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http://dx.doi.org/10.1159/000490693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470339PMC
December 2018
1 Read

Comment on: Subspecialization in radiology - Is it time to hatch out of the cocoon?

Indian J Radiol Imaging 2019 Jan-Mar;29(1):106-107

Body Imaging, Department of Radiology, USF Health, Tampa, Florida, USA.

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http://dx.doi.org/10.4103/ijri.IJRI_511_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467044PMC

Explanation of radiological signs and fracture indices in a unicameral bone cyst.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):104-106

Department of Radiology, Holy Family Hospital, Thodupuzha, Kerala, India. E-mail:

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http://dx.doi.org/10.4103/ijri.IJRI_443_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467030PMC

Congenital biotinidase deficiency - MRI findings in two cases.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):99-103

Consultant Radiologist, Vikas Diagnostics, Kanpur, Uttar Pradesh, India.

Congenital biotinidase deficiency is a rare inborn error of metabolism that most commonly presents in infantile age group. Diffusion changes on magnetic resonance imaging (MRI) are sparsely described in the literature. We are presenting diffusion-weighted MRI findings in two confirmed cases of congenital biotinidase deficiency in infantile age group with review of literature. Read More

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http://www.ijri.org/text.asp?2019/29/1/99/255223
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http://dx.doi.org/10.4103/ijri.IJRI_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467045PMC
April 2019
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Commentary: Noncardiac uses of chest ultrasonography other than pleural effusion.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):98

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.4103/ijri.IJRI_102_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467039PMC

Ultrasonography and X-Ray guided drain placement to evacuate a pneumopericardium/pneumomediastinum in a 1-day-old infant.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):94-97

Children's Hospital Cardiology Center, Women's and Children's Hospital, University of Missouri Health Care, Columbia, USA.

Ultrasonographic (US) guided procedures have wide range of application in the abdomen and pelvis, however their role is somewhat limited in the chest due to complete reflection of the ultrasound beam by the air in the lungs, preventing the direct imaging of the tissues deep to the air-sound interface. Most of the chest procedures, other than the exception of thoracentesis, rely on the use of CT (computed tomography) scan. The disadvantages of using CT scan is the cost, lack of portability, and most importantly the radiation involved, particularly in case of infants and children, whose tissues are more radiosensitive than the adults. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_447_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467035PMC

A rare case of neonatal mastauxe: Case report.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):89-93

Department of Radiodiagnosis, Baroda Medical College, Maharaja Sayajirao University, Vadodara, India.

Neonatal breast enlargements have varying number of presentations on imaging and these have been underreported in the literature. Our case report profiles a 2-week-old female who presented with a history of bilateral breast enlargement with redness and clear, non-bloody, milk-like discharge, who was clinically diagnosed and managed for neonatal mastitis, which was actually a neonatal breast enlargement only. Awareness on neonatal breast enlargement that can be just physiological without any associated mastitis or inflammatory/infective changes can prevent unnecessary hospitalization and treatment with parenteral antibiotics. Read More

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http://www.ijri.org/text.asp?2019/29/1/89/255225
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http://dx.doi.org/10.4103/ijri.IJRI_317_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467042PMC
April 2019
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Multimodality imaging features of primary breast lymphoma - A rare entity.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):85-88

Department of Pathology, Command Hospital, Kolkata, West Bengal, India.

Primary lymphoma of breast is very rare which has no tell-tale imaging characteristics. Multimodality imaging helps not only in suggesting the possibility of lymphoma but also in its management. We present here one such case which was extensively worked up with various imaging modalities and was histologically proven as primary breast lymphoma. Read More

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http://www.ijri.org/text.asp?2019/29/1/85/255227
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http://dx.doi.org/10.4103/ijri.IJRI_344_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467037PMC
April 2019
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Coronary artery air embolism complicating a CT-guided percutaneous lung biopsy.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):81-84

Department of Medical Oncology and Stem Cell Transplantation, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

Coronary arterial air embolism is an extremely rare but readily recognizable condition on computed tomography (CT) that may complicate a lung biopsy. We present an incidence of symptomatic air embolism into the right coronary artery during a percutaneous CT-guided lung biopsy that was successfully recognized during the procedure and managed accordingly. An active search for this complication should be made when the patient deteriorates on table and the usual complications (pneumothorax, vasovagal shock, etc. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_347_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467034PMC

Subcutaneous emphysema, pneumothorax and pneumomediastinum as a complication of an asthma attack.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):77-80

Internal Medicine Department, Hospital Universitario de Torrejón, Calle Mateo Inurria s/n, Torrejón de Ardoz, Spain.

Introduction: Simultaneous subcutaneous emphysema, spontaneous pneumothorax, and pneumomediastinum are complications rarely observed synchronously during an acute exacerbation of bronchial asthma. Although spontaneous pneumothorax has already been reported in asthma patients in the literature, its concurrence with subcutaneous emphysema and pneumomediastinum is extremely rare except for iatrogenic conditions.

Case Study: We describe a patient who presented to the emergency room with progressive dyspnea and chest pain. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_340_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467038PMC

Primary intracranial leiomyoma - A case report and literature review.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):72-76

Department of Radiology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.

Primary intracranial leiomyoma is a rare tumour of mesenchymal origin, with less than 30 cases reported in literature including two cases from the Indian subcontinent. In this article, we describe a case of primary intracranial leiomyoma in an immunocompromised patient with a brief review of literature. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_250_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467049PMC

Upper limb peripheral neuropathy in sickle cell anemia: MR neurography appearances.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):67-71

Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

Sickle cell anemia is an inherited disorder with many systemic complications. Peripheral neuropathy related to this disorder has been sparsely reported. We report an interesting case of upper limb peripheral neuropathy from sickle cell disease with emphasis on MR neurography appearances and electrophysiology correlation. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_364_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467032PMC

Non-radiation occupational hazards and health issues faced by radiologists - A cross-sectional study of Indian radiologists.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):61-66

Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Context: Radiologists as a group face unique occupational health hazards among which musculoskeletal injuries, chronic eye strain, and others are yet to receive adequate attention. Constant mental strain due to demanding turnaround times and work pressures may lead to burnout and depression. These combine to decrease overall work satisfaction and productivity. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_403_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467047PMC

The investigation of dose and image quality of chest computed tomography using different combinations of noise index and adaptive statistic iterative reconstruction level.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):53-60

Department of Radiological Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.

Background: Computed tomography (CT) automatic tube current modulation (ATCM) systems and iterative reconstruction (IR) play an important role in CT radiation dose optimization. How the two can best be used together is one of the challenges faced by radiology professionals.

Aim: To determine optimum settings of ATCM noise index (NI) together with adaptive statistic iterative reconstruction (ASIR) for a general electric (GE) scanner that aims to achieve similar image quality to the standard protocol used in the hospital (Smart mA technique with NI of 11. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467048PMC

Early experience of combination therapy of transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma measuring 3-7 cm.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):47-52

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background Of The Article: Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide. Radiofrequency ablation (RFA) is considered curative option in selected patients; efficacy is severely limited by lesion size and lesions bordering a large vessel. On the other hand, transarterial chemoembolization (TACE) is not limited by lesion size and arterial occlusion of the tumor feeding vessels leads to increase the volume of the ablative zone. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_352_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467046PMC

Safety and outcomes of pre-operative portal vein embolization using N-butyl cyanoacrylate (Glue) in hepatobiliary malignancies: A single center retrospective analysis.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):40-46

Department of Liver Transplantation and Hepato Pancreatico Biliary Surgery, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India.

Aims And Objectives: To evaluate the outcome of preoperative portal vein embolization (PVE) using N-butyl cyanoacrylate (NBCA) for change in future liver remnant (FLR) volume, biochemical changes, and procedure-related complications. The factors affecting FLR hypertrophy and the rate of resection was also evaluated for this cohort.

Materials And Methods: From 2012 to 2017, PVE utilizing NBCA mixed with lipiodol (1:4) was performed using percutaneous approach in 28 patients with hepatobiliary malignancies with low FLR. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_454_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467029PMC

Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):33-39

Department of Radiodiagnosis, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: Cardiac iron deposition in transfusion-dependent thalassemia patients is patchy in distribution.

Purpose: The purpose of this study is to assess the correlation between T2* matrices of membranous interventricular septum (MIVS) and T2* values of muscular interventricular septum (IVS) on magnetic resonance imaging (MRI) and to evaluate the relationship of myocardial T2* at these two locations with MRI-estimated liver iron concentrations (LIC) and electrocardiographic (ECG) parameters.

Material And Methods: MRI of heart and liver was performed in 16 consecutive pediatric patients of transfusion-dependent thalassemia major to calculate liver iron concentration and T2* time of membranous and muscular IVS. Read More

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http://www.ijri.org/text.asp?2019/29/1/33/255233
Publisher Site
http://dx.doi.org/10.4103/ijri.IJRI_395_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467041PMC
April 2019
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Role of apparent diffusion coefficient as a biomarker in the evaluation of cervical cancer.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):25-32

Department of Radiation Oncology, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India.

Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) has evolved as a major diagnostic and prognostic tool in cervical cancer. The aim of our study was to compare the change in mean apparent diffusion coefficient (ADC) value before and after concurrent chemoradiation therapy (CCRT) in carcinoma cervix thereby establishing its role as a cancer biomarker.

Materials And Methods: A hospital-based prospective study was conducted in 35 patients diagnosed with cervical cancer. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_441_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467043PMC

Adhesive capsulitis: MRI correlation with clinical stages and proposal of MRI staging.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):19-24

Department of Radio Diagnosis, Govt Stanley Medical College, Affiliated to The Tamilnadu Dr. MGR Medical University, No 69, Anna Salai, Guindy, Chennai, India.

Objective: The purpose of this study was to correlate the magnetic resonance imaging (MRI) findings of adhesive capsulitis with clinical stages and thereby propose a MR staging system.

Materials And Methods: This study consisted of 74 patients with clinically diagnosed adhesive capsulitis. The edema of the inferior glenohumeral ligament (IGHL), pericapsular edema, thickness of anterior band of IGHL, axillary pouch, thickness of coracohumeral ligament, and obliteration of fat in the subcoracoid triangle were evaluated by MRI. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467040PMC

"Honeycomb" pattern of gallbladder wall thickening - A forward step in early diagnosis of "Severe Dengue Fever".

Indian J Radiol Imaging 2019 Jan-Mar;29(1):14-18

Department of Radiology, Apollo Hospitals International Limited, Gandhinagar, India.

Aims And Objectives: To study "Honeycomb" pattern of gallbladder wall thickening (GBWT) in dengue fever (DF) and to assess its clinical significance in early diagnosis of severe DF.

Materials And Methods: A total 244 patients of DF were studied, 84 patients were classified as severe DF, 61 patients as DF with warning signs, and 99 patients as DF without warning signs. Abdominal ultrasound was performed for assessment of GBWT patterns, hepatomegaly, splenomegaly, pancreatic enlargement, ascites, pleural effusion, and other additional findings were recorded in severe DF cases. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_363_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467033PMC

Corrosive injuries of the upper gastrointestinal tract: A pictorial review of the imaging features.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):6-13

Department of Gastroenterology, Postgraduate Institute of Medical Imaging and Research (PGIMER), Chandigarh, India.

Corrosive ingestion is a common form of poisoning. Corrosive agents cause severe damage to the gastrointestinal (GI) tract. The most severe forms of injury can lead to mortality; however, the major concern with this type of injury is life-long morbidity. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_349_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467036PMC