18 results match your criteria Indian Journal of Pathology & Microbiology [Journal]

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Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours.

J Pathol 2017 11 28;243(3):331-341. Epub 2017 Sep 28.

Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.

Biallelic mismatch repair deficiency (bMMRD) in tumours is frequently associated with somatic mutations in the exonuclease domains of DNA polymerases POLE or POLD1, and results in a characteristic mutational profile. In this article, we describe the genetic basis of ultramutated high-grade brain tumours in the context of bMMRD. We performed exome sequencing of two second-cousin patients from a large consanguineous family of Indian origin with early onset of high-grade glioblastoma and astrocytoma. Read More

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http://dx.doi.org/10.1002/path.4957DOI Listing
November 2017
36 Reads

The revised guidelines of the Medical Council of India for academic promotions: Need for a rethink.

J Family Med Prim Care 2015 Oct-Dec;4(4):483-6

Editor, The National Medical Journal of India, New Delhi, India.

Note: This editorial is being published simultaneously in the Indian Heart Journal, Indian Journal of Anaesthesia, Indian Journal of Gastroenterology, Indian Journal of Medical Ethics, Indian Journal of Medical Microbiology, Indian Journal of Occupational and Environmental Medicine, Indian Journal of Pathology and Microbiology, Indian Journal of Pharmacology, Indian Journal of Physiology and Pharmacology, Indian Journal of Urology, Indian Pediatrics, International Journal of Health Research & Medicolegal Practice, Journal of Anaesthesiology Clinical Pharmacology, Journal of Ayurveda and Integrative Medicine, Journal of Clinical and Scientific Research, Journal of Conservative Dentistry, Journal of Family Medicine and Primary Care, Journal of Indian Academy of Forensic Medicine, Journal of Mahatma Gandhi Institute of Medical Sciences, Journal of Postgraduate Medicine, National Journal of Integrated Research in Medicine, and The National Medical Journal of India. It may also be published in forthcoming issues of other journals. This editorial is not endorsed by all members of the Indian Association of Medical Journal Editors (IAMJE). Read More

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http://dx.doi.org/10.4103/2249-4863.174332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776596PMC
March 2016
7 Reads

Indian Journal of Pathology and Microbiology. From the Editor's desk.

Authors:
Vatsala Misra

Indian J Pathol Microbiol 2014 Apr-Jun;57(2):177

Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0377-4929.134657DOI Listing
April 2015
1 Read

References in the Indian Journal of Pathology and Microbiology: are they accurate?

Indian J Pathol Microbiol 2012 Jan-Mar;55(1):135-7

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http://dx.doi.org/10.4103/0377-4929.94903DOI Listing
August 2012
1 Read

Increased production of sonic hedgehog by ballooned hepatocytes.

J Pathol 2011 Jul 5;224(3):401-10. Epub 2011 May 5.

Division of Cellular Therapy, Hematology and Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Ballooned hepatocytes distinguish non-alcoholic steatohepatitis (NASH) from steatosis. Such cells contain dilated endoplasmic reticulum and ubiquitin aggregates, characteristics of endoplasmic reticulum stress. Hepatocyte ballooning increases the risk for fibrosis in NASH, suggesting that ballooned hepatocytes release pro-fibrogenic factors. Read More

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http://dx.doi.org/10.1002/path.2888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628812PMC
July 2011
1 Read

Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression.

J Pathol 2008 Dec;216(4):460-70

INSERM, Unité 841, Créteil F-94000, France.

Recent studies have revealed the potential involvement of Hedgehog (Hh) signalling in proliferation and invasive behaviour of prostate carcinoma (PCa). The aim of this study was to specify the role of Sonic Hh (Shh), Desert Hh (Dhh) and Indian Hh (Ihh) in the natural history of PCa. Hh ligands expression was compared in primary hormone-naive PCa (HNPC), hormone-treated PCa (HTPC) and hormone-refractory PCa (HRPC), using immunohistochemistry. Read More

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http://dx.doi.org/10.1002/path.2427DOI Listing
December 2008
2 Reads

Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.

J Pathol 2007 Oct;213(2):131-9

First Department of Internal Medicine, Sapporo Medical University, Sapporo 060-8543, Japan.

Hedgehog-interacting protein (HHIP) was identified as a putative antagonist of the Hh pathway and as a target of Hh signalling. Our aim was to clarify the expression profiles and epigenetic alterations of the HHIP gene in gastrointestinal cancer. The expression and promoter epigenetic status of HHIP in cancer cell lines and freshly resected gastrointestinal cancer tissues were examined using RT-PCR, tissue microarray analysis, methylation-specific PCR, and chromatin immunoprecipitation assay. Read More

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http://dx.doi.org/10.1002/path.2216DOI Listing
October 2007
2 Reads

Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.

J Pathol 2006 Aug;209(4):501-11

Department of Pathology, Leiden University Medical Centre, The Netherlands.

Hedgehog (HH) signalling is important for specific developmental processes, and aberrant, increased activity has been described in various tumours. Disturbed HH signalling has also been implicated in the hereditary syndrome, Multiple Osteochondromas. Indian Hedgehog (IHH), together with parathyroid hormone-like hormone (PTHLH), participates in the organization of growth plates in long bones. Read More

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http://dx.doi.org/10.1002/path.2008DOI Listing

EXT-related pathways are not involved in the pathogenesis of dysplasia epiphysealis hemimelica and metachondromatosis.

J Pathol 2006 Jul;209(3):411-9

Department of Pathology, Leiden University Medical Centre, The Netherlands.

Dysplasia epiphysealis hemimelica (DEH) and metachondromatosis (MC) are considered in the differential diagnosis of solitary and hereditary osteochondromas. Both are rare disorders with DEH demonstrating cartilaginous overgrowth of an epiphysis and MC exhibiting synchronous enchondromas and osteochondromas. Ten cases of DEH and two of MC were compared with osteochondromas at the histological and molecular level. Read More

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http://dx.doi.org/10.1002/path.1985DOI Listing

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation.

J Pathol 2005 Dec;207(4):453-61

Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.

Indian hedgehog (Ihh) is actively involved in endochondral bone formation. Although expression of Ihh is mostly restricted to pre-hypertrophic chondrocytes, the role of chondrocyte-derived Ihh in endochondral bone formation is not completely understood. To address such unresolved issues, we used the Cre/loxP approach to generate mice (Col2alpha1Cre; Ihhd/Ihhd) in which the Ihh gene was selectively ablated from collagen type II expressing cells. Read More

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http://dx.doi.org/10.1002/path.1870DOI Listing
December 2005
3 Reads

Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.

J Pathol 2005 Mar;205(4):476-82

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Enchondromas and conventional central chondrosarcomas are, respectively, benign and malignant hyaline cartilage-forming tumours that originate in the medulla of bone. In order to gain a better understanding of the molecular process underlying malignant transformation of enchondroma, and to investigate whether there is a biological difference between conventional central cartilaginous tumours and those of enchondromatosis or with phalangeal localization, a series of 64 enchondromas (phalanx, n = 21; enchondromatosis, n = 15) and 89 chondrosarcomas (phalanx, n = 17; enchondromatosis, n = 13) was collected. Indian Hedgehog (IHH)/parathyroid hormone related peptide (PTHrP) signalling, an important pathway in chondrocyte proliferation and differentiation within the normal growth plate, was studied by immunohistochemical analysis of the expression of PTHrP, PTHR1, Bcl-2, p21, cyclin D1, and cyclin E. Read More

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http://dx.doi.org/10.1002/path.1723DOI Listing
March 2005
2 Reads

Copper-associated liver disease in North Ronaldsay sheep: a possible animal model for non-Wilsonian hepatic copper toxicosis of infancy and childhood.

J Pathol 2001 Sep;195(2):264-9

Department of Veterinary Pathology, University of Liverpool, UK.

Indian childhood cirrhosis (ICC), endemic Tyrolean infantile cirrhosis (ETIC) and idiopathic copper toxicosis (ICT), are clinically and pathologically indistinguishable liver disorders of infants and young children linked with exogenous copper and with increasing evidence for a genetic predisposition. North Ronaldsay sheep are a primitive breed which have adapted to a copper impoverished environment (<5 ppm) and display an abnormal sensitivity to copper poisoning when transferred to a copper replete (11 ppm) habitat. The aetiological parallels prompted a study of copper-associated liver disease in North Ronaldsay sheep (RCT) to see if the pathology could contribute to the understanding of the childhood disorder. Read More

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http://dx.doi.org/10.1002/path.930DOI Listing
September 2001

An animal model for copper-associated cirrhosis in infancy.

J Pathol 1998 Oct;186(2):215-21

Division of Paediatrics, University of Sheffield, Children's Hospital, U.K.

In Indian childhood cirrhosis (ICC) and related disorders of infancy, hepatic copper overload is associated with cirrhosis. Since copper administration alone has not been shown to induce cirrhosis in animals, synergy between copper and a second hepatotoxin has been suggested. This study investigates the ability of long-term exposure to copper and a pyrrolizidine alkaloid, retrorsine, to produce a model of copper-associated cirrhosis in rats. Read More

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http://dx.doi.org/10.1002/(SICI)1096-9896(1998100)186:2<215::AID-PATH145>3.0.CO;2-CDOI Listing
October 1998

Morphological patterns of articular cartilage fibrillation.

J Pathol 1975 Apr;115(4):231-40

The morphology of articular cartilage fibrillation is usually studied in sections cut vertical to the surface. The present study instead concerns the appearances seen when the surface is viewed en face. The study has been made on indian ink preparations of unfixed, hydrated tissue mounted in physiological saline and examined by stereomicroscopy at times 10 while in situ on the bone, and by transmitted light microscopy of tangential surface slices at magnifications up to times 150. Read More

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http://dx.doi.org/10.1002/path.1711150408DOI Listing

Lymphoid leucosis in an indian python (Python molurus).

Authors:
E P Finnie

J Pathol 1972 Aug;107(4):295-7

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http://dx.doi.org/10.1002/path.1711070409DOI Listing
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