260,178 results match your criteria Indian Journal for the Practising Doctor [Journal]


Genetic association of DNMT variants can play a critical role in defining the methylation patterns in autism.

IUBMB Life 2019 Feb 20. Epub 2019 Feb 20.

Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediated by methylation patterns which are established and maintained by DNA methyltransferases. Read More

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http://dx.doi.org/10.1002/iub.2021DOI Listing
February 2019

Growth, Challenges and Opportunities in Indian Nursing.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

College of Nursing, Bharati Vidyapeeth Deemed University, Pune, India.

In India, nurses and midwives make up more than 30% of the national healthcare workforce (World Health Organisation, 2016). The country has also witnessed a phenomenal growth in the uptake of nursing education with an increase during the last eight years of Graduate nursing schools; 285 to 3215, BSc colleges; 30 to 1936, and MSc nursing colleges; 10 to 643 (Indian Nursing Council, 2019). Many of the BSc and MSc colleges are now moving to health universities and deemed institutes. Read More

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http://dx.doi.org/10.1111/jan.13978DOI Listing
February 2019

Resolution of grammatical tense into actual time, and its application in Time Perspective study in the tweet space.

PLoS One 2019 20;14(2):e0211872. Epub 2019 Feb 20.

Department of Computer Science and Engineering, Indian Institute of Technology Patna, Bihar, India.

Time Perspective (TP) is an important area of research within the 'psychological time' paradigm. TP, or the manner in which individuals conduct themselves as a reflection of their cogitation of the past, the present, and the future, is considered as a basic facet of human functioning. These perceptions of time have an influence on our actions, perceptions, and emotions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211872PLOS
February 2019

Brain stem death - an overview.

Med Leg J 2019 Feb 20:25817218822008. Epub 2019 Feb 20.

2 Department of Forensic Medicine, Kasturba Medical College (affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India), Mangalore, India.

The concept of brain death has been a very intriguing topic and has taken many forms over the years. Brain stem death is a complex state of inactivity defined by the loss of reflexes of the pathways that pass through the brain stem, the 'shaft' of the brain which links the spinal cord to the cerebral cortex and the cerebellum where there is apnoea, loss of eye movement and pain sensation. There are many criteria, based on which a person can be said to be brain dead. Read More

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http://dx.doi.org/10.1177/0025817218822008DOI Listing
February 2019

A multifunctional catenated host for the efficient binding of Eu and Gd.

Chem Commun (Camb) 2019 Feb 20. Epub 2019 Feb 20.

School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Kolkata 700032, India.

A new multifunctional [2]catenane is synthesized by using a phenanthroline-based heteroditopic wheel and Axle, which acts as a receptor for the efficient binding of lanthanide ions such as Eu3+ and Gd3+. Read More

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http://dx.doi.org/10.1039/c9cc00090aDOI Listing
February 2019

The State of the Evidence for Whole-System, Multi-Modality Naturopathic Medicine: A Systematic Scoping Review.

J Altern Complement Med 2019 Feb;25(2):141-168

1 National Centre for Naturopathic Medicine, Southern Cross University, Lismore, Australia.

Objective: To summarize the current state of the research evidence for whole-system, multi-modality naturopathic medicine.

Design: A systematic search for research articles from around the world was undertaken using MEDLINE, Embase, CINAHL, AMED, and WHO regional indexes. Naturopathic journals and gray literature were hand searched. Read More

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http://dx.doi.org/10.1089/acm.2018.0340DOI Listing
February 2019

Cryo-Electron Microscopy Uncovers Key Residues within the Core of Alpha-Synuclein Fibrils.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Protein Folding and Dynamics Laboratory, Structural Biology and Bioinformatics Division , CSIR-Indian Institute of Chemical Biology , 4, Raja Subodh Chandra Mullick Road , Kolkata 700032 , India.

Recent expeditious advances in the determination of the 3-D structure of fibrils of alpha-synuclein, the intrinsically disordered protein associated with the neurodegenerative Parkinson's disease (PD), have identified amino acid contacts that form the fibril's inter-protofilament interface. The residues that constitute this "steric zipper" interface determine the morphology of the fibrils as well as toxicity of the oligomeric building units or "kernels" which lead to the formation of the protofilaments. The zipper interface houses key amino acid residues involved in familial PD that can be targeted by drug design. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00090DOI Listing
February 2019

Correction: A smart molecular probe for selective recognition of nitric oxide in 100% aqueous solution with cell imaging application and DFT studies.

Org Biomol Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, Jadavpur University, Kolkata 700 032, India. and Vice-Chancellor, Aliah University, ll-A/27, Action Area II, Newtown, Kolkata, West Bengal 700160, India.

Correction for 'A smart molecular probe for selective recognition of nitric oxide in 100% aqueous solution with cell imaging application and DFT studies' by Ananya Dutta et al., Org. Biomol. Read More

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http://dx.doi.org/10.1039/c9ob90033kDOI Listing
February 2019

The aryne Sommelet-Hauser rearrangement.

Chem Commun (Camb) 2019 Feb 20. Epub 2019 Feb 20.

Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, India.

An aryne induced transition-metal-free and mild Sommelet-Hauser rearrangement of tertiary benzylamines for the synthesis of α-aryl amino acid derivatives in moderate to good yields is presented. Unlike the conventional Sommelet-Hauser rearrangement of ammonium salts, the methodology developed herein requires neither harsh conditions nor strong bases. Moreover, a temperature dependent switchable selectivity for the Sommelet-Hauser and Stevens [1,2] rearrangements has been observed. Read More

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http://dx.doi.org/10.1039/c9cc00629jDOI Listing
February 2019

V-shaped active plasmonic meta-polymers.

Nanoscale 2019 Feb 20. Epub 2019 Feb 20.

Department of Physics, Indian Institute of Science Education and Research Pune, Pune 411008, India.

We report the design and fabrication of V-shaped plasmonic meta-polymers on a glass substrate or silicon wafer using a surface functionalization approach. The efficacy of the assembly method is examined by analyzing the surface enhanced Raman scattering by an individual V-shaped antenna experimentally and using computational simulations to determine the polarization dependence of local electromagnetic field enhancement. Read More

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http://dx.doi.org/10.1039/c8nr10034aDOI Listing
February 2019

Melanocyte spheroids are formed by repetitive long-term trypsinization.

Indian J Dermatol Venereol Leprol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.

Background: Autologous melanocyte transplantation plays an important role in the treatment of vitiligo.

Objective: Previous studies have indicated that, compared with melanocytes growing in monolayers, melanocyte spheroids have a better survival in growth factor- and serum-deprived conditions.

Methods: Melanocyte spheroids were obtained from human epidermis by repetitive long-term trypsinization and maintained an aggregated morphology for a short period in certain conditions. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_275_17DOI Listing
February 2019

Lichenoid skin lesions: A rare manifestation in secondary syphilis.

Indian J Dermatol Venereol Leprol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Chile Clinical Hospital, Santiago, Chile.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_200_18DOI Listing
February 2019

Chitosan-based biocompatible dressing for treatment of recalcitrant lesions of cutaneous leishmaniasis: A pilot clinical study.

Indian J Dermatol Venereol Leprol 2019 Feb 19. Epub 2019 Feb 19.

Department of Polymer Engineering, Amirkabir University of Technology, Tehran, Iran.

Background: Chitosan has a biocompatible, biodegradable and nontoxic nature. The effectiveness of nano-chitosan films in the treatment of cutaneous leishmaniasis has been confirmed previously in susceptible laboratory animals.

Aims: The aim of this study is to evaluate the safety and efficacy of a chitosan-based biocompatible dressing in patients with cutaneous leishmaniasis who were either nonresponsive to or had medical contraindications for conventional treatments. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_189_18DOI Listing
February 2019

Pseudoxanthomatous or xanthelasmoid mastocytosis: Reporting a rare entity.

Indian J Dermatol Venereol Leprol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Mastocytosis is a disease characterized by abnormal and pathologic increase in mast cells in the cutaneous tissue and extracutaneous organs such as the bone marrow, liver, spleen, lymph node and gastrointestinal tract. Cutaneous mastocytosis comprises of four major clinical variants: solitary and multiple mastocytomas, urticaria pigmentosa, diffuse cutaneous mastocytosis and telangiectasia macularis eruptiva perstans. Cutaneous mastocytosis of the xanthelasmoid type is a rare variant of diffuse mastocytosis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_633_17DOI Listing
February 2019

Novel nanocomposite derived from ZnO/CdS QDs embedded crosslinked chitosan: An efficient photocatalyst and effective antibacterial agent.

J Hazard Mater 2019 Feb 10;369:398-407. Epub 2019 Feb 10.

Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad, 826004, India. Electronic address:

A novel nanocomposite (cl-Ch-pMAc@ZnO/CdSQDs) has been developed under microwave irradiation via fabrication of ZnO/CdS quantum dots on anionically functionalized chitosan [i.e. poly (methacrylic acid) crosslinked chitosan (cl-Ch-pMAc) in the presence of diethylene glycol dimethacrylate (DEGDMA) crosslinker]. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.022DOI Listing
February 2019

Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.

Eur J Med Chem 2019 Feb 14;167:510-524. Epub 2019 Feb 14.

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. Electronic address:

The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and β-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. Among the tested inhibitors, 25, 26, 40, and 41 presented the most significant and balanced inhibition against both the targets. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.030DOI Listing
February 2019

Pollution assessment and spatial distribution of roadside agricultural soils: a case study from India.

Int J Environ Health Res 2019 Feb 20:1-14. Epub 2019 Feb 20.

a Department of Botany , DAV University , Jalandhar , India.

The present work studied the pH, organic carbon, phosphorus (P), calcium (Ca), magnesium (Mg), and heavy metals Cu, Cr, Co and Pb in roadside agricultural soils of Jalandhar environs of Punjab, India. A total of 120 samples in triplicates were collected from different sites for assessment of heavy metal pollution. The mean values of Cu, Cr, Co and Pb were found below the permissible limits of Indian and Swedish soil limits. Read More

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http://dx.doi.org/10.1080/09603123.2019.1578865DOI Listing
February 2019

Topotactic Ion Exchange in a Three-Dimensional Close-Packed Trirutile Structure with an Octahedral Network.

Inorg Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry , Indian Institute of Technology (IIT) Roorkee , Roorkee 247 667 , India.

Topotactic ion exchange in open-framework solids and oxides with layered and tunnel structures has resulted in the formation of a variety of metastable functional materials that are inaccessible otherwise. These ion exchanges are primarily limited to the above structure types because of the presence of labile ions as loosely held charge-compensating cations/anions as in the framework or tunnel structures or the lability of the ions/charged motifs in interlayer galleries of layered oxides. While such topotactic exchanges are common in the above structure types, they are rare in the three-dimensional (3D) close-packed structures based solely on corner- and/or edge-connected polyhedral networks. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03491DOI Listing
February 2019

The mechanism of phosphatidylcholine-induced interference of PAP (248-286) aggregation.

J Pept Sci 2019 Feb 19:e3152. Epub 2019 Feb 19.

Department of Biotechnology, Central University of Rajasthan, Ajmer, India.

Seminal amyloids are well known for their role in enhancing HIV infection. Among all the amyloidogenic peptides identified in human semen, PAP was found to be the most active and was termed as semen-derived enhancer of viral infection (SEVI). Although amyloidogenic nature of the peptide is mainly linked with enhancement of the viral infection, the most active physiological conformation of the aggregated peptide remains inconclusive. Read More

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http://dx.doi.org/10.1002/psc.3152DOI Listing
February 2019

Evidence for dynamic resource partitioning between two sympatric reef shark species within the British Indian Ocean Territory.

J Fish Biol 2019 Feb 19. Epub 2019 Feb 19.

Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Canada.

Stable-isotope analyses (δ C, δ N and δ S) of multiple tissues (fin, muscle, red blood cells and plasma), revealed ontogenetic shifts in resource use by grey reef sharks Carcharhinus amblyrhynchos and resource partitioning with silvertip sharks Carcharhinus albimarginatus within the British Indian Ocean Territory marine protected area (MPA). Resource partitioning varied temporally, with C. albimarginatus feeding on more pelagic prey during October to January, potentially attributable to an influx of pelagic prey from outside the MPA at that time. Read More

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http://dx.doi.org/10.1111/jfb.13938DOI Listing
February 2019

Cost of Treatment of Valvular Heart Disease at a Tertiary Hospital in North India: Policy Implications.

Pharmacoecon Open 2019 Feb 19. Epub 2019 Feb 19.

School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Lack of data on the cost of cardiac care is an impediment to evidence-based planning, especially for determining provider payment rates under publically financed health insurance schemes.

Objective: This study estimates the unit costs of outpatient consultation, hospitalization, intensive care, selected surgical procedures and diagnostics for providing cardiac care for valvular heart disease at a tertiary hospital in India.

Methods: We undertook an economic costing of cardiac care using both patient and health system perspectives. Read More

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http://dx.doi.org/10.1007/s41669-019-0123-6DOI Listing
February 2019

Achalasia cardia: A diagnosis often delayed!

Authors:
Mayank Jain

Indian J Gastroenterol 2019 Feb 19. Epub 2019 Feb 19.

Department of Gastroenterology, Gleneagles Global Health City, Chennai 600 101, India.

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http://dx.doi.org/10.1007/s12664-019-00942-xDOI Listing
February 2019

IFN-g:IL-10 Ratio: a Putative Predictive Biomarker to Discriminate HLH From Severe Viral Infections.

J Clin Immunol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), 13th floor, Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai, 400012, India.

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http://dx.doi.org/10.1007/s10875-019-00601-yDOI Listing
February 2019

Protein signatures linking history of miscarriages and metabolic syndrome: a proteomic study among North Indian women.

PeerJ 2019 14;7:e6321. Epub 2019 Feb 14.

Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi, India.

Background: Metabolic syndrome (MeS), a constellation of metabolic adversities, and history of miscarriage make women at a higher risk for cardiovascular diseases (CVDs). However, molecular evidence indicating a link between the two phenotypes (history of miscarriage and MeS) among women would offer an opportunity to predict the risk factor for CVDs at an early stage. Thus, the present retrospective study attempts to identify the proteins signatures (if any) to understand the connection between the history of miscarriage and MeS. Read More

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http://dx.doi.org/10.7717/peerj.6321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378092PMC
February 2019

Dacar Cas/Somali Red Aloe: a new species of (Asphodelaceae) from Somaliland.

PhytoKeys 2019 8(117):85-97. Epub 2019 Feb 8.

Biodiversity Museum, University of Hargeisa, Hargeisa, Somaliland.

A new species of Aloe (Asphodelaceae) is described from Somaliland. It differs from other species in forming large clumps and in having sap that is initially yellow but quickly turns bright red and then dark red or reddish-brown, paniculate red-flowered inflorescences and uniformly coloured leaves with red teeth. Its recognition raises the number of species known from the combined area of Somaliland and Somalia s. Read More

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http://dx.doi.org/10.3897/phytokeys.117.28226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377413PMC
February 2019

(Zingiberaceae), a new species of ginger lily from Northeast India.

PhytoKeys 2019 6(117):73-84. Epub 2019 Feb 6.

Tropical Ecology and Evolution (TrEE) Lab, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, 462066, India Indian Institute of Science Education and Research Bhopal India.

We describe from Northeast India (NE India) which was discovered during one of our recent botanical explorations in Arunachal Pradesh. We provide detailed morphological comparison of this species with four other species ( R.M. Read More

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http://dx.doi.org/10.3897/phytokeys.117.24951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374353PMC
February 2019

Digital gangrene induced by inadvertent intra-arterial cocktail injection of anesthetic agents such as pentazocine, promethazine, and atropine: A serious adverse drug experience.

Indian J Pharmacol 2018 Nov-Dec;50(6):354-357

Department of CTVS, Superspecialty Hospital, GMC, Jammu, Jammu and Kashmir, India.

Gangrenous changes in skin due to accidental intra-arterial injection of promethazine and pentazocine have been reported. Accidental intra-arterial injection is most commonly encountered in the antecubital fossa. However, recent reports in the radial and ulnar arteries have also been encountered. Read More

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http://dx.doi.org/10.4103/ijp.IJP_131_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364335PMC
February 2019

A case of capecitabine-induced dermatomyositis.

Indian J Pharmacol 2018 Nov-Dec;50(6):350-353

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Dermatomyositis (DM) is an idiopathic, inflammatory connective tissue disorder characterized by symmetrical proximal myopathy and characteristic skin involvement. The pathogenesis of DM is widely debated; however, it is postulated to be an end result of immune-mediated cascade, triggered by multiple environmental factors in a genetically predisposed individual. In addition to underlying malignancies, many drugs have been reported to be associated with DM. Read More

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http://dx.doi.org/10.4103/ijp.IJP_356_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364339PMC
February 2019

A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis.

Indian J Pharmacol 2018 Nov-Dec;50(6):344-349

Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion-associated phlebitis.

Materials And Methods: Patients aged 18-65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6-8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Read More

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http://dx.doi.org/10.4103/ijp.IJP_201_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364337PMC
February 2019

Sulfated polysaccharides of seagrass suppresses tumor necrosis factor-α-induced chemokine interleukin-8 secretion in HT-29 cell line.

Indian J Pharmacol 2018 Nov-Dec;50(6):336-343

Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry, India.

Objectives: The present study aims to investigate the anti-oxidant and anti-inflammatory properties of seagrass sulfated polysaccharide on HT-29 cell line.

Subjects And Methods: Monosaccharides composition was identified using liquid chromatography-mass spectrometry (LC-MS) and the functional groups were analyzed using Fourier transform-infrared (FT-IR) spectroscopy. The antioxidant and anti-inflammatory potential of crude extract and purified fractions was investigated . Read More

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http://dx.doi.org/10.4103/ijp.IJP_202_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364340PMC
February 2019

Efficacy ratio: A tool to enhance optimal antimicrobial use for intra-abdominal infections.

Indian J Pharmacol 2018 Nov-Dec;50(6):332-335

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Antimicrobial resistance and inappropriate antibiotic regimen hamper a favorable outcome in intra-abdominal infections. Clinicians rely on the minimum inhibitory concentration (MIC) value to choose from the susceptible antimicrobials. However, the MIC values cannot be directly compared between the different antibiotics because their breakpoints are different. Read More

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http://dx.doi.org/10.4103/ijp.IJP_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364343PMC
February 2019

Evaluation of (indigenous drug) as oxidative stress down-regulator using serum-free explant culture system.

Indian J Pharmacol 2018 Nov-Dec;50(6):326-331

Food and Drug Toxicology Research Centre, ICMR National Institute of Nutrition, Hyderabad, Telangana, India.

Context: The importance of phytochemicals/natural products as potential therapeutic agents in the present context is gaining a lot of importance. India with a rich heritage of such preparations needs evaluation as potent drugs. Explant culture system is a method, which is sensitive, reliable, reproducible and is capable of mimicking the conditions maintaining the tissue in sufficiently high level of integration. Read More

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http://dx.doi.org/10.4103/ijp.IJP_480_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364338PMC
February 2019

Analysis of glycemic status in diabetes-naïve patients on statins: A hospital-based cross-sectional study.

Indian J Pharmacol 2018 Nov-Dec;50(6):320-325

Department of Cardiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Introduction: Randomized controlled trials, observational studies, and meta-analysis suggest risk of hyperglycemia in patients on statins, and this association is being viewed with renewed interest globally. The present study has tried to explore the possible diabetogenic effect of statins, the mechanism of this effect, and various comorbidities associated with this causation.

Materials And Methods: This cross-sectional study was carried out at the Department of Cardiology from October 2015 to March 2017. Read More

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http://dx.doi.org/10.4103/ijp.IJP_132_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364334PMC
February 2019

Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction.

Indian J Pharmacol 2018 Nov-Dec;50(6):309-319

Department of Pharmaceutical Sciences, PDM University, Bahadurgarh, Haryana, India.

Objective: The aim of the present study was to evaluate the solanesol (SNL)-mediated coenzyme-Q10 restoration to ameliorate 3-nitropropionic (3-NP)-induced behavioral, biochemical, and histological changes which resemble Huntington's disease (HD)-like symptoms in men.

Materials And Methods: Various behavioral and biochemical parameters were carried out to evaluate the activity of SNL on 3-NP-treated rats. To determine the therapeutic significance of SNL on HD, different behavioral tests such as memory task, locomotor activity, grip strength, and beam cross and some biochemical test along with histopathological findings were done. Read More

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http://dx.doi.org/10.4103/ijp.IJP_11_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364342PMC
February 2019

Management of myasthenia gravis during pregnancy.

Indian J Pharmacol 2018 Nov-Dec;50(6):302-308

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The management of myasthenia gravis (MG) during pregnancy requires special skills as both diseases as well as its treatment can have deleterious effects on mother and fetus. MG often affects women in second and third decades of life during the childbearing age. Exacerbations of MG are likely to occur during the first trimester and postpartum period. Read More

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http://dx.doi.org/10.4103/ijp.IJP_452_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364336PMC
February 2019

Connectomics: A pharmacologic viewpoint.

Indian J Pharmacol 2018 Nov-Dec;50(6):299-301

Department of Pharmacology, PGIMER, Chandigarh, India.

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http://dx.doi.org/10.4103/ijp.IJP_2_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364341PMC
February 2019

Multiple Testing and Protection Against a Type 1 (False Positive) Error Using the Bonferroni and Hochberg Corrections.

Indian J Psychol Med 2019 Jan-Feb;41(1):99-100

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

In a given study, if many related outcomes are tested for statistical significance, one or more outcomes may emerge significant at the < 0.05 level not because they are truly significant in the population but because of chance. The larger the number of statistical tests performed, the greater the risk that some of the significant findings are significant because of chance. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_499_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337927PMC
February 2019

"I Stopped Hearing Voices, Started to Stutter" - A Case of Clozapine-Induced Stuttering.

Indian J Psychol Med 2019 Jan-Feb;41(1):97-98

InSTAR Program, Schizophrenia and Metabolic Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_157_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337922PMC
February 2019

Comments on "Leisure Time Physical Activity and Risk of Developing Depression among the Youth of Kangra District, Himachal Pradesh, India".

Indian J Psychol Med 2019 Jan-Feb;41(1):93-94

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_444_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337924PMC
February 2019

Early Diagnosis and Intervention for Autism Spectrum Disorder: Need for Pediatrician-Child Psychiatrist Liaison.

Indian J Psychol Med 2019 Jan-Feb;41(1):87-90

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Early interventions in children with autism spectrum disorder (ASD) reduce progressive symptom development. Delay in diagnosis and initiation of ASD-specific interventions is observed across settings. This study aimed to assess the trends in time to diagnosis and treatment initiation in a tertiary care pediatric setting. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_154_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337936PMC
February 2019

Sexual Dysfunction among Men in Rural Tamil Nadu: Nature, Prevalence, Clinical Features, and Explanatory Models.

Indian J Psychol Med 2019 Jan-Feb;41(1):81-86

Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India.

Background And Aim: There is a dearth of community data on nature, prevalence, clinical features, and explanatory models related to sexual dysfunction among men, particularly from rural India. This study attempted to examine different aspects of male sexual dysfunction and misconceptions in the community.

Materials And Methods: Villages in Kaniyambadi Block, Vellore district were stratified, and four were randomly selected. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_153_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337923PMC
February 2019

Illness Perception of Anxiety Patients in Primary Care in Singapore.

Indian J Psychol Med 2019 Jan-Feb;41(1):75-80

James Cook University, Singapore.

Background: The majority of people with anxiety tend to seek help in primary care. Patients' illness perception regarding their own anxiety can influence the assessment, treatment processes, and outcomes. This cross-sectional study explored possible relationships between patients' illness perception of their anxiety and the severity of their anxiety. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_101_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337938PMC
February 2019

Pathways to Care for Patients with Bipolar-I Disorder: An Exploratory Study from a Tertiary Care Centre of North India.

Indian J Psychol Med 2019 Jan-Feb;41(1):68-74

Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Understanding the pathways to psychiatric care is important from a public health perspective. Only a few Indian studies have focused on this, particularly for severe mental disorders. The present study was planned to assess it in patients with Bipolar-I disorder (BD-I). Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_201_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337925PMC
February 2019

Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India.

Indian J Psychol Med 2019 Jan-Feb;41(1):61-67

Department of Psychiatry, MOSC Medical College, Kolenchery, Kerala, India.

Background: Bipolar affective disorder (BAD) is a severe mental illness which results in serious lifelong struggles and challenges. The full impact of stressful life events (SLEs) on the course of BAD is poorly understood.

Materials And Methods: A cross-sectional study was conducted on 128 consecutive patients with BAD currently admitted with a relapse. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_113_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337920PMC
February 2019

Magnitude of Mental Morbidity and Its Correlates with Special Reference to Household Food Insecurity among Adult Slum Dwellers of Bankura, India: A Cross-Sectional Survey.

Indian J Psychol Med 2019 Jan-Feb;41(1):54-60

Department of Community Medicine, Principal, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Mental disorders cause considerable morbidity and disability, and there is ample evidence that mental disorders are positively associated with household food insecurity.

Methods: A cross-sectional survey was conducted for a period of 2 months at Bakultala slum of Bankura town involving 152 people of ≥18 and ≤60 years of age selected using simple random sampling technique to estimate the prevalence of mental disorders and to find out its correlates. Information pertaining to socio-demographics and household food security (HHFS) and " potential psychiatric case" were collected through a house to house interview of the head of the household, using predesigned questionnaire, Bengali version of self-reporting questionnaire, and 6-item household food security scale (HFSS). Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_129_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337931PMC
February 2019

Factors Associated with Depression among School-going Adolescent Girls in a District of Northern India: A Cross-sectional Study.

Indian J Psychol Med 2019 Jan-Feb;41(1):46-53

MBA Department, Institute of Engineering and Technology, Lucknow, Uttar Pradesh, India.

Context: Depression among adolescents, especially among girls, is a rising public health problem worldwide. It has been associated with a profound negative impact on their physical, social, and mental well-being.

Aim Of The Study: To ascertain the factors associated with depression among school-going adolescent girls in district Barabanki of Uttar Pradesh. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_211_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337940PMC
February 2019