262,821 results match your criteria Indian Journal for the Practising Doctor [Journal]


Optimization of operating conditions of miniaturize single chambered microbial fuel cell using NiWO/graphene oxide modified anode for performance improvement and microbial communities dynamics.

Bioresour Technol 2019 Apr 11;285:121337. Epub 2019 Apr 11.

School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, U.P. 221005, India. Electronic address:

NiWO and graphene oxide (NWG) modified anodic carbon cloth (CC) is used to improve the performance of single chambered microbial fuel cell (SMFC) by statistical optimization of operational parameters. The properties of synthesized NWG nanocomposite on the surface of modified anode are characterized by FTIR, XRD, EDX, TEM and SEM analysis. The optimum level of operational parameters maximize the power density (PD) 1458 mW/m of SMFC having NWG modified anode and observed 8. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121337DOI Listing

A review on biochar modulated soil condition improvements and nutrient dynamics concerning crop yields: Pathways to climate change mitigation and global food security.

Chemosphere 2019 Mar 29;227:345-365. Epub 2019 Mar 29.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

The beneficial role of biochar on improvement of soil quality, C sequestration, and enhancing crop yield is widely reported. As such there is not much consolidated information available linking biochar modulated soil condition improvement and soil nutrient availability on crop yields. The present review paper addresses the above issues by compilation of world literature on biochar and a new dimension is introduced in this review by performing a meta-analysis of published data by using multivariate statistical analysis. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.03.170DOI Listing

Phylogenomics clarifies biogeographic and evolutionary history, and conservation status of West Indian tremblers and thrashers (Aves: Mimidae).

Mol Phylogenet Evol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biology, Boston University, Boston, MA, USA.

The West Indian avifauna has provided fundamental insights into island biogeography, taxon cycles, and the evolution of avian behavior. Our interpretations, however, should rely on robust hypotheses of evolutionary relationships and consistent conclusions about taxonomic status in groups with many endemic island populations. Here we present a phylogenetic study of the West Indian thrashers, tremblers, and allies, an assemblage of at least 5 species found on 29 islands, including what is considered the Lesser Antilles' only avian radiation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10557903193003
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http://dx.doi.org/10.1016/j.ympev.2019.04.016DOI Listing
April 2019
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Dermatological Implications of Galectin-3 in Circulation: An Evaluation From the Perspective of Patients With Differential Manifestations of Post-Kala-Azar Dermal Leishmaniasis.

Am J Dermatopathol 2019 Apr 10. Epub 2019 Apr 10.

Departments of Laboratory Medicine, and.

Galectin-3, a β-galactoside-binding lectin, has been implicated in vast repertoire of inflammatory and immunomodulatory processes including skin diseases. However, galectin-3 has not been comprehensively studied in infectious diseases. This study emphasizes on fascinating aspects of galectin-3 expression in dermal infection by studying post-kala-azar dermal leishmaniasis (PKDL), an intracellular infection caused by Leishmania donovani. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001412DOI Listing

Rhodium(III)-Catalyzed Directed C-H Dienylation of Anilides with Allenes Leads to Highly Conjugated Systems.

Org Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of Chemistry , Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road , Bhauri, Bhopal 462066 , Madhya Pradesh , India.

Allenes are unique coupling partners in transition-metal-catalyzed C-H functionalization leading to a variety of products via alkenylation, allenylation, allylation, and annulation reactions. The outcome is governed by both the reactivity of the allene and the formation and stability of the organometallic intermediate. An efficient Rh(III)-catalyzed, weakly coordinating group-directed dienylation of electronically unbiased allenes is developed using an N-acyl amino acid as a ligand. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00958DOI Listing

Visible-Light-Mediated β-C(sp)-H Amination of Glycosylimidates: En Route to Oxazoline-Fused/Spiro Nonclassical Bicyclic Sugars.

Org Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of Chemistry , Indian Institute of Technology Patna , Bihta 801106 , Bihar , India.

A straightforward route has been developed for the diastereoselective synthesis of nonclassical conformationally constrained oxazoline-fused and spiro bicyclic sugars bearing a quaternary center via selective β-C-H amination of appropriately positioned glycosylimidates. The desired transformation proceeds via the generation of imidate N-radicals under visible-light conditions followed regioselective intramolecular N-C bond formation. The reactions tolerate broad functional groups under the optimized conditions. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00763DOI Listing

Enantioselective [4 + 2]-Annulation of Azlactones with Copper-Allenylidenes under Cooperative Catalysis: Synthesis of α-Quaternary α-Acylaminoamides.

Org Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of Organic Chemistry , Indian Institute of Science , Bangalore - 560012 , India.

The first enantioselective decarboxylative [4 + 2]-annulation of ethynyl benzoxazinanones with azlactones has been developed under cooperative copper and bifunctional tertiary aminourea catalysis. This direct and modular approach combines dipolar copper-allenylidene intermediates with azlactone enolates and allows for the synthesis of α-quaternary α-acylaminoamides as a single diastereomer generally in high yields with good to excellent enantioselectivities (up to 99:1 er). Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01103DOI Listing

A large nodule on the scalp of an Indian female.

Eur J Dermatol 2019 Feb;29(1):110

Department of Dermatology, Royal London Hospital, Whitechapel, London, UK.

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http://dx.doi.org/10.1684/ejd.2019.3513DOI Listing
February 2019

Expanding Environmental Health Literacy-A Focus on Water Quality and Tribal Lands.

J Health Commun 2019 Apr 18:1-8. Epub 2019 Apr 18.

c Department of Social and Behavioral Science , Harvard T.H. Chan School of Public Health , Boston , MA , USA.

Environmental health literacy (EHL), an evolving concept, has potential for significant public health impact. However, complex skills are needed to access and use information, to study and document hazards, to link findings to health outcomes, and to understand the complexities of regulations and laws needed to take efficacious action. Because water issues are creating headlines world-wide, we draw from several water-related cases on American Indian tribal lands to examine some of the complexities associated with building needed skills, obtaining accessible information, and navigating the layers of laws and regulations that enable or inhibit efficacious action. Read More

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https://www.tandfonline.com/doi/full/10.1080/10810730.2019.1
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http://dx.doi.org/10.1080/10810730.2019.1597948DOI Listing
April 2019
1 Read

Modelling the Inhibition of Selenoproteins by Small Molecules using Cysteine and Selenocysteine Derivatives.

Chemistry 2019 Apr 18. Epub 2019 Apr 18.

Indian Institute of Science, Inorganic & Physical Chemistry, Indian Institute of Science, 560 012, Bangalore, INDIA.

Small molecule-based electrophilic compounds such as 1-chloro-2,4-dinitrobenzene (CDNB), 1-chloro-4-nitrobenzene (CNB) are being used as inhibitors of cysteine- and selenocysteine-containing proteins. CDNB has been used extensively to determine the activity of glutathione S-transferase and to deplete glutathione (GSH) in mammalian cells. Also, CDNB has been shown to irreversibly inhibit the thioredoxin reductase (TrxR), a selenoenzyme that catalyzes the reduction of thioredoxin (Trx). Read More

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http://dx.doi.org/10.1002/chem.201901363DOI Listing

Synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E from a common synthetic intermediate.

Org Biomol Chem 2019 Apr 18. Epub 2019 Apr 18.

Department of Organic Synthesis & Process Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India.

The stereoselective synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E, from a common synthetic intermediate, is disclosed. The propargylic sulfide stereocenter is created stereoselectively via carbon-carbon bond formation in the reaction of α-chloro sulfides with alkynylzinc reagents via 1,2-asymmetric induction by a β-siloxy group. The characteristic 1,4-diol motif of the natural products is introduced by a [2,3] sigmatropic rearrangement of an allylic sulfoxide or by the Mislow-Evans-Braverman rearrangement of a propargylic sulfoxide followed by stereoselective reduction of the ensuing α,β-unsaturated ketone. Read More

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http://dx.doi.org/10.1039/c9ob00623kDOI Listing

Genetic diversity and structural analysis of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) from .

J Vector Borne Dis 2018 Oct-Dec;55(4):271-281

Protein Biochemistry and Structural Biology Laboratory, ICMR-National Institute of Malaria Research, New Delhi, India.

Background & Objectives: Plasmodium parasite harbours unique methylerythritol phosphate (MEP) pathway which is obligatory for the biosynthesis of isoprenoids. In malaria parasites, the isoprenoids are indispensable during hepatic, erythrocytic and gametocytic stages. Owing to the criticality of MEP pathway and the potential of its enzymes to act as antimalarial drug target, this study comprehensively investigated the genetic diversity and structural composition of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE), fourth enzyme of MEP pathway in Indian Plasmodium falciparum (PfIspE). Read More

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http://dx.doi.org/10.4103/0972-9062.256562DOI Listing
April 2019
1 Read

Three Co(II) Metal-Organic Frameworks with Diverse Architectures for Selective Gas Sorption and Magnetic Studies.

Inorg Chem 2019 Apr 18. Epub 2019 Apr 18.

Department of Chemistry , Indian Institute of Technology , Kharagpur , Kharagpur-721302 WB , India.

Three Co(II) metal-organic frameworks, namely, {[Co(L)(OBA)(HO)]· xG} (1), {[Co(L)(OBA)]· xG} (2), and {[Co(L)(OBA)(HO)]·DMA· xG} (3) [where L = 2,5-bis(3-pyridyl)-3,4-diaza-2,4-hexadiene, HOBA = 4,4'-oxybisbenzoic acid, DMF = dimethylformamide, DMA = dimethylacetamide, and G denotes disordered guest molecules], have been synthesized under diverse reaction conditions through self-assembly of a bent dicarboxylate and a linear spacer with a Co(II) ion. While 1 is crystallized at room temperature in DMF to form a 2D layer structure, 2 is formed by the assembly of similar components under solvothermal conditions with a 3D network structure. On the other hand, changing the solvent to DMA, 3 could be crystallized at room temperature with a 3D architecture. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00471DOI Listing

Pediatric Radiology: Why the Pediatricians Need it?

Indian J Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Imaging, Hospital for Sick Children/Medical Imaging, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s12098-019-02940-5DOI Listing

Barriers and opportunities for improving childhood immunization coverage in slums: A qualitative study.

Prev Med Rep 2019 Jun 28;14:100858. Epub 2019 Mar 28.

National Polio Surveillance Project, Mumbai, Maharashtra, India.

There is substantial variability in immunization coverage trends across the globe which can be attributed to a number of factors such as demographic profile, socioeconomic characteristics and political environment. Vaccine preventable diseases contribute to severe disease burden when coverage is low, particularly, in slums. Present qualitative study explored barriers, opportunities, and key facilitators of childhood immunization. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.100858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453822PMC

Development and utilization of A and B gene-based diagnostics for the phytoplasma classified under 16Sr I group in plants and insects.

3 Biotech 2019 May 13;9(5):177. Epub 2019 Apr 13.

2Amity Institute of Biotechnology, Amity University, Manesar, Haryana 122413 India.

In the present study, a new set of primers of A and B genes of the phytoplasma genome were designed and validated for the successful detection and taxonomic classification of the previously identified phytoplasma strains of ' P. asteris' (16SrI-B subgroup) associated with Catharanthus leaf yellows, sesame phyllody and the leafhopper (). Our results suggested the ability and sensitivity of and genes as an alternative molecular marker to identify the . Read More

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http://link.springer.com/10.1007/s13205-019-1706-8
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http://dx.doi.org/10.1007/s13205-019-1706-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462283PMC
May 2019
1 Read

Assessing oil accumulation in the oleaginous yeast JRC1 using dairy waste cheese whey as a substrate.

3 Biotech 2019 May 10;9(5):173. Epub 2019 Apr 10.

Environmental Biotechnology Laboratory, Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur (IIT J), Jodhpur, Rajasthan 342037 India.

This study assesses the potential for the lipid production by the oleaginous yeast JRC1 using dairy industry waste cheese whey as a substrate. Cheese whey was used either untreated (UCW) or deproteinized (DCW) at different concentrations (25-100%) to serve as the carbon and energy source. Both UCW and DCW supported high biomass and lipid productivities. Read More

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http://dx.doi.org/10.1007/s13205-019-1701-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458212PMC

Taxonomic characterization and antimicrobial compound production from BDK01 isolated from marine sediment.

3 Biotech 2019 May 4;9(5):167. Epub 2019 Apr 4.

4Department of Biotechnology, Bharathiar University, Coimbatore, 641 046 India.

sp. isolated from marine sediment collected from Palk Strait, Bay of Bengal was investigated for its antagonistic potential. The isolate exhibited antimicrobial activity against selected bacterial strains of clinical importance such as MTCC 3160, NCIM 2327, (methicillin resistant), MTCC 1698, (ESBL), MTCC 1457, and Phenotypic and molecular characterization ascertained the isolate BDK01 as . Read More

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http://dx.doi.org/10.1007/s13205-019-1687-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449414PMC

Targeted therapy in cervical cancer.

ESMO Open 2018 7;3(Suppl 1):e000462. Epub 2019 Feb 7.

Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Cervical cancer continues to be a common cancer in women worldwide, especially in less developed regions where advanced stage presentations are common. Addition of bevacizumab to cytotoxic chemotherapy has been the only notable recent advance in the treatment of recurrent and metastatic cervical cancer. Outcomes in patients with locally advanced disease have also plateaued after meaningful gains were achieved with concomitant chemoradiation treatment. Read More

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http://dx.doi.org/10.1136/esmoopen-2018-000462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438352PMC
February 2019

Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition.

Medchemcomm 2019 Mar 23;10(3):421-430. Epub 2019 Jan 23.

Department of Pharmaceutical Chemistry , ISF College of Pharmacy , Moga-142001 , Punjab , India . Email: ; ; Tel: +91 1636 324200.

In the present work, coumarin based pyrazolines () have been synthesized and investigated for their and anti-inflammatory potential. Amongst the synthesized compounds, compounds , and exhibited significant anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, investigations were carried out carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound was found to possess appreciable anti-inflammatory and analgesic potential. Read More

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http://xlink.rsc.org/?DOI=C8MD00457A
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http://dx.doi.org/10.1039/c8md00457aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430084PMC
March 2019
1 Read

In silico optimization of enzyme mediated debittering of Assam lemon: biochemical and sensory evaluation studies.

J Food Sci Technol 2019 Apr 21;56(4):2233-2243. Epub 2019 Mar 21.

2Department of Agricultural and Food Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721302 India.

Commercialization of citrus fruit juice is always hindered by the bitterness development in juice when stored for a significant period of time. In order to debitter citrus juice, an attempt has been taken up by treating the juice with tannase. Central Composite Design (CCD) based Response Surface Methodology (RSM) has been implemented to evaluate and optimize the effect of underlying process parameters viz. Read More

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http://link.springer.com/10.1007/s13197-019-03710-z
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http://dx.doi.org/10.1007/s13197-019-03710-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443759PMC
April 2019
1 Read

Evaluation of physicochemical characteristics of microwave vacuum dried mackerel and inhibition of oxidation by essential oils.

J Food Sci Technol 2019 Apr 19;56(4):1890-1898. Epub 2019 Feb 19.

2Central Institute of Fisheries Technology, Kochi, Kerala 629503 India.

In the present study, Indian mackerel was dried by microwave vacuum drying (MVD) method and compared its physico chemical quality to mackerel dried by hot air drying (HAD) method. Antioxidant effects of thyme oil (TMO) and clove leaf oils (CLO) during storage were also evaluated. Brine salted mackerel was dried in hot air oven (50-55 °C) and microwave vacuum dryer (600 W and 600 Hg mm). Read More

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http://link.springer.com/10.1007/s13197-019-03651-7
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http://dx.doi.org/10.1007/s13197-019-03651-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443817PMC
April 2019
1 Read

Development of electrochemical biosensor based on CNT-FeO nanocomposite to determine formaldehyde adulteration in orange juice.

J Food Sci Technol 2019 Apr 18;56(4):1829-1840. Epub 2019 Feb 18.

2CSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi, 110012 India.

An electrochemical biosensor was developed to determine formaldehyde (HCHO) adulteration commonly found in food. The current responses of various electrodes based on multiwalled carbon nanotubes (CNTs) and synthesized nanocomposite (CNT-FeO) were measured using cyclic voltammetry. The nanocomposite based biosensor shows comparatively high sensitivity (527 µA mg/L cm), low detection limit (0. Read More

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http://dx.doi.org/10.1007/s13197-019-03635-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443716PMC

Onion ( L.) is potentially a good source of important antioxidants.

J Food Sci Technol 2019 Apr 13;56(4):1811-1819. Epub 2019 Feb 13.

3Kuwait Institute for Scientific Research, P.O. Box 24884, 13109 Safat, Kuwait.

Six different cultivars of onions available in the Kuwaiti market were analyzed for various physic-chemical properties, such as, moisture content, sugar composition, TBARS as malondialdehyde, total phenolic content, as well as trolox equivalent antioxidant capacity, these cultivars comprised of US onions white, US onions yellow, Indian onions red, Egyptian onions red, New Zealand onions golden and Saudi onions white. Layers from each onion bulb were manually cut and separated into three nearly equal portions, i.e. Read More

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http://dx.doi.org/10.1007/s13197-019-03625-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443770PMC

Effect of γ-irradiation on physico-chemical and antioxidant properties of galactan exopolysaccharide from KR780676.

J Food Sci Technol 2019 Apr 5;56(4):1766-1774. Epub 2019 Mar 5.

Department of Food Science and Technology, Pondicherry University, Pondicherry, 605014 India.

Exopolysaccharide (EPS) produced by KR780676 from an Indian fermented food () has been characterized as galactan in earlier report. In this study, the galactan EPS was irradiated at different doses (0, 4, 8, and 16 kGy) using Co as γ-source and effect of γ-irradiation on physico-chemical and antioxidant potential of galactan EPS was studied. Color and flow properties showed moderate change after the γ-irradiation treatment. Read More

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http://dx.doi.org/10.1007/s13197-019-03608-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443816PMC

Process optimization and characterization of 'sev' (traditional Indian extruded snack) with the incorporation of mushroom powder.

J Food Sci Technol 2019 Apr 4;56(4):1723-1731. Epub 2019 Feb 4.

Department of Food Science and Technology, G.B. Pant University of Agriculture and Technology, Pantnagar, India.

Mushroom is a nutritious and palatable food with various health attributes. The mushroom powder is a rich source of vegetable protein. In the present study, efforts were made to optimize the process for making , a traditional Indian extruded snack, with the incorporation of mushroom powder () to the Bengal gram ( L. Read More

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http://dx.doi.org/10.1007/s13197-019-03599-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443744PMC

Rheological evaluations and molecular marker analysis of cultivated bread wheat varieties of India.

J Food Sci Technol 2019 Apr 31;56(4):1696-1707. Epub 2019 Jan 31.

2Division of Genetics, ICAR-Indian Agricultural Research Institute, New Delhi, 110012 India.

The aim of this study was to screen Indian cultivated wheat varieties and list out the parameters/genes required to be improved for an end-product. Therefore, 30 Indian wheat varieties under cultivation by farmers were screened for 14 physico-chemical and rheological parameters, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) for high molecular weight glutenin subunits (HMW-GS), DNA based molecular markers for low molecular weight glutenin subunits (LMW-GS) and puroindolines () genes. Based on grain texture, sedimentation value, farinographic, alveographic, HMW-GS and LMW-GS and biscuit making parameters, HS490 was found to be a highly suited for biscuit and soft wheat products. Read More

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http://dx.doi.org/10.1007/s13197-019-03593-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443729PMC

Impact of conservation tillage in rice-based cropping systems on soil aggregation, carbon pools and nutrients.

Geoderma 2019 Apr;340:104-114

International Maize and Wheat Improvement Center (CIMMYT), South Asia Regional Office, Kathmandu, Nepal.

Tillage intensive cropping practices have deteriorated soil physical quality and decreased soil organic carbon (SOC) levels in rice-growing areas of South Asia. Consequently, crop productivity has declined over the years demonstrating the need for sustainable alternatives. Given that, a field experiment was conducted for six years to assess the impact of four tillage based crop establishment treatments [puddled transplant rice followed by conventional tillage in wheat/maize (CTTPR-CT), non-puddled transplant rice followed by zero-tillage in wheat/maize (NPTPR-ZT), zero-till transplant rice followed by zero-tillage in wheat/maize (ZTTPR-ZT), zero-tillage direct seeded rice followed by zero-tillage in wheat/maize (ZTDSR-ZT)], two residue management treatments [residue removal, residue retention (~33%)], and two cropping systems [rice-wheat, rice-maize] on soil aggregation, carbon pools, nutrient availability, and crop productivity. Read More

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http://dx.doi.org/10.1016/j.geoderma.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358044PMC

Phenazine-1-carboxamide functionalized mesoporous silica nanoparticles as antimicrobial coatings on silicone urethral catheters.

Sci Rep 2019 Apr 17;9(1):6198. Epub 2019 Apr 17.

Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India.

Microbial infections due to biofilms on medical implants can be prevented by antimicrobial coatings on biomaterial surfaces. Mesoporous silica nanoparticles (MSNPs) were synthesized via base-catalyzed sol-gel process at room temperature, functionalized with phenazine-1-carboxamide (PCN) and characterized by UV-visible, FT-IR, DLS, XRD spectroscopic techniques, SEM, TEM, TGA and BET analysis. Native MSNPs, PCN and PCN-MSNPs were evaluated for anti-Candida minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), Candida albicans (C. Read More

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http://dx.doi.org/10.1038/s41598-019-42722-9DOI Listing

Hospital-derived antibody profiles of malaria patients in Southwest India.

Malar J 2019 Apr 17;18(1):138. Epub 2019 Apr 17.

Department of Chemistry and Department of Global Health, University of Washington, Seattle, WA, 98195, USA.

Background: Naturally acquired immunity to malaria across the globe varies in intensity and protective powers. Many of the studies on immunity are from hyperendemic regions of Africa. In Asia, particularly in India, there are unique opportunities for exploring and understanding malaria immunity relative to host age, co-occurrence of Plasmodium falciparum and Plasmodium vivax infections, varying travel history, and varying disease severity. Read More

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http://dx.doi.org/10.1186/s12936-019-2771-5DOI Listing

The Welfare of Cows in Indian Shelters.

Animals (Basel) 2019 Apr 16;9(4). Epub 2019 Apr 16.

Centre for Animal Welfare and Ethics, School of Veterinary Science, The University of Queensland, Gatton Campus, Australia 4343, Australia.

Cow shelters (gaushalas) are unique traditional institutions in India, where aged, infertile, diseased, rescued, and abandoned cows are sheltered for the rest of their life, until they die of natural causes. These institutions owe their existence to the reverence for the cow as a holy mother goddess for Hindus, the majority religion in India. There is a religious and legal prohibition on cow slaughter in most Indian states. Read More

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https://www.mdpi.com/2076-2615/9/4/172
Publisher Site
http://dx.doi.org/10.3390/ani9040172DOI Listing
April 2019
1 Read

Dietary Change Scenarios and Implications for Environmental, Nutrition, Human Health and Economic Dimensions of Food Sustainability.

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Laboratory of Sustainable Food Processing, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland.

Demand side interventions, such as dietary change, can significantly contribute towards the achievement of 2030 national sustainable development goals. However, most previous studies analysing the consequences of dietary change focus on a single dimension of sustainability (e.g. Read More

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http://dx.doi.org/10.3390/nu11040856DOI Listing

Effect of fluorine substitution on sintering behaviour, mechanical and bioactivity of hydroxyapatite.

J Mech Behav Biomed Mater 2019 Apr 9;95:136-142. Epub 2019 Apr 9.

Bioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, 196 Raja S.C. Mullick Road, Kolkata 700032, India. Electronic address:

Fluorine substituted hydroxyapatite (FAp) with different degree of fluorine (F) substitution, has been synthesized using hydrothermal synthesis method. In the present work, as synthesized powders were consolidated by sintering at 1200 °C in air for 1 h. The sintered specimens were characterized using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) for phase analysis. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.03.032DOI Listing

Response of grassland ecosystem to monsoonal precipitation variability during the Mid-Late Holocene: Inferences based on molecular isotopic records from Banni grassland, western India.

PLoS One 2019 17;14(4):e0212743. Epub 2019 Apr 17.

Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.

Banni, located in the arid western India, is one of the largest tropical grasslands of the Asian continent. The net primary production in this grassland ecosystem is currently mediated by precipitation during the Indian summer monsoon (ISM). However, timing of the grassland expansion and its link to the intensity of monsoonal precipitation remains enigmatic due to the paucity of datasets. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212743PLOS

Changing paradigm of antibiotic resistance amongst Escherichia coli isolates in Indian pediatric population.

PLoS One 2019 17;14(4):e0213850. Epub 2019 Apr 17.

Department of Microbiology, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

Antimicrobial resistance happens when microorganisms mutates in manners that render the drugs like antibacterial, antiviral, antiparasitic and antifungal, ineffective. The normal mutation process is encouraged by the improper use of antibiotics. Mutations leading to quinolone resistance occur in a highly conserved region of the quinolone resistance-determining region (QRDR) of DNA gyrAse and topoisomerase IV gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213850PLOS

Non-muscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.

Mol Biol Cell 2019 Apr 17:mbcE18120790. Epub 2019 Apr 17.

School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

Though many cancers are known to show upregulation of Nonmuscle myosin (NM) IIA and -IIB, the mechanism by which NMIIs aid in cancer development remains unexplored. Here we demonstrate that tumor-generating, fibroblast-like cells isolated from 3-methylcholanthrene (3MC)-induced murine tumor exhibit distinct phospho-dependent localization of NMIIA and NMIIB at the perinuclear area and tip of the filopodia and affect cell migration differentially. While NMIIA-KD affects protrusion dynamics and increases cell directionality, NMIIB-KD lowers migration speed and increases filopodial branching. Read More

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http://dx.doi.org/10.1091/mbc.E18-12-0790DOI Listing

Google classroom as a learning management system to teach biochemistry in a medical school.

Authors:
Sambit Dash

Biochem Mol Biol Educ 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education (MAHE), Karnataka, India.

Medical education has adopted various e-learning technologies to its aid. Addition of Google Classroom, introduced in 2014, as a Learning Management System (LMS) has provided a basic, easy to use platform. This study tested its efficacy in teaching a biochemistry module to first year MBBS students in an Indian medical school. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bmb.21246
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http://dx.doi.org/10.1002/bmb.21246DOI Listing
April 2019
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Identification of natural compound inhibitors against PfDXR: A hybrid structure-based molecular modeling approach and molecular dynamics simulation studies.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, Gujarat, India.

In the present contribution, multicomplex-based pharmacophore studies were carried out on the structural proteome of Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Among the constructed models, a representative model with complementary features, accountable for the inhibition was used as a primary filter for the screening of database molecules. Auxiliary evaluations of the screened molecules were performed via drug-likeness and molecular docking studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28714
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http://dx.doi.org/10.1002/jcb.28714DOI Listing
April 2019
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A Single Atom Change Facilitates the Membrane Transport of Green Fluorescent Proteins in Mammalian Cells.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

Indian Institute of Science, Bangalore, 560012, Bangalore, INDIA.

Direct delivery of proteins into mammalian cells is a challenging problem in biological and biomedical applications. The most common strategies for the delivery of proteins into the cells include the use of cell-penetrating peptides or supercharged proteins. Herein, we show for the first time that a single atom change, hydrogen to halogen, at one of the tyrosine residues can increase the cellular entry of 28 kDa green fluorescent protein (GFP) in mammalian cells. Read More

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http://dx.doi.org/10.1002/anie.201902347DOI Listing

Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells.

Org Biomol Chem 2019 Apr 17. Epub 2019 Apr 17.

Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, 411008, India.

Toxoplasma gondii is a ubiquitous eukaryotic pathogen responsible for toxoplasmosis in humans and animals. This parasite is an obligate intracellular pathogen and actively invades susceptible host cells, a process which is mediated by specific receptor-ligand interactions. Here, we have identified an unnatural 2,4-disulfated d-glucuronic acid (Di-S-GlcA), a hexuronic acid composed of heparin/heparan sulfate, as a potential carbohydrate ligand that can selectively bind to T. Read More

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http://dx.doi.org/10.1039/c9ob00744jDOI Listing

A N,N-dimethylformamide protected rhodium nanocluster with engrossing optical properties and its application.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram, Kerala-695551, India.

Here, we present the synthesis and characterization of a new N,N-dimethylformamide (DMF) protected rhodium nanocluster (Rh NC) and its interesting optical properties. These small clusters are emissive and exhibit inhomogeneous broadening. The origin of the inhomogeneous broadening and emission behavior were investigated through detailed photo-physical studies. Read More

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http://dx.doi.org/10.1039/c9dt01036jDOI Listing

Equatorial ligand plane perturbations lead to a spin-state change in an iron(iii) porphyrin dimer.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India.

A complete reversal of the spin state of iron(iii) is observed upon a small change to the diporphyrin bridge from ethane to ethene by keeping all other factors intact. Combined analysis using single crystal X-ray structure determination, Mössbauer, variable-temperature magnetic, 1H NMR and EPR studies has confirmed the spin states of iron(iii) complexes both in solid and solution phases. Read More

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http://xlink.rsc.org/?DOI=C9DT01182J
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http://dx.doi.org/10.1039/c9dt01182jDOI Listing
April 2019
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Mercapto-benzothiazolyl based ruthenium(ii) borate complexes: synthesis and reactivity towards various phosphines.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.

The synthesis and reactivity of ruthenium complexes containing an anionic boron based ligand, supported by mercapto-benzothiazolyl heterocycles are presented. Specifically, the reaction of [(η6-p-cymene)Ru{P(OMe)2OR}Cl2], (1a: R = Me; 1b: R = H) with [H2B(mbz)2]- (mbz = 2-mercaptobenzothiazolyl) at room temperature afforded a series of borate complexes, namely [(L)Ru{κ3-H,S,S'-H2B(L)2}P(O)(OMe)(HL)], 2, [Ru{κ3-H,S,S'-H2B(L)2}2], 3 and [(κ2-N,S-L)P(OMe)3Ru{κ3-H,S,S'-H2B(L)2}], 4a; (L = C7H4NS2). The pivotal feature of 2 is the coordination of the Ru centre with a phosphorus atom of secondary phosphine oxide and mercapto-benzothiazolyl ligands. Read More

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http://dx.doi.org/10.1039/c9dt00498jDOI Listing

Acceptorless dehydrogenative construction of C[double bond, length as m-dash]N and C[double bond, length as m-dash]C bonds through catalytic aza-Wittig and Wittig reactions in the presence of an air-stable ruthenium pincer complex.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781039, India.

The construction of C[double bond, length as m-dash]N bonds was achieved by the dehydrogenative coupling of alcohol and azide via aza-Wittig type reaction. The reaction is catalyzed by an acridine-derived ruthenium pincer complex and does not use any oxidant. The present protocol offers a wide substrate scope, including aliphatic, aryl or heteroaryl alcohol/azides. Read More

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http://dx.doi.org/10.1039/c8dt04725aDOI Listing

A Comparative Study of Single-Trait and Multi-Trait Genomic Selection.

J Comput Biol 2019 Apr 17. Epub 2019 Apr 17.

ICAR-Indian Agricultural Statistics Research Institute, Pusa, New Delhi, India.

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https://www.liebertpub.com/doi/10.1089/cmb.2019.0032
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http://dx.doi.org/10.1089/cmb.2019.0032DOI Listing
April 2019
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Feasibility of measuring sodium, potassium and creatinine from urine sample on dried filter paper.

Bioanalysis 2019 Apr 17. Epub 2019 Apr 17.

Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

To develop a bioassay for estimation of sodium, potassium and creatinine in dried urine strips and comparing with their respective concentration in liquid urine samples. Urine was collected on filter paper strips, dried at room temperature and, eluted for estimation of sodium, potassium by indirect ion selective electrode method and creatinine by Jaffé method. This bioassay was validated based on the US FDA guidelines for bioanalytical method validation and was linear, sensitive, accurate and precise with acceptable recovery and matrix effects. Read More

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https://www.future-science.com/doi/10.4155/bio-2018-0295
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http://dx.doi.org/10.4155/bio-2018-0295DOI Listing
April 2019
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3.003 Impact Factor

Facile measurement of protein stability and folding kinetics using a nano differential scanning fluorimeter.

Protein Sci 2019 Apr 16. Epub 2019 Apr 16.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India.

With advancements in high-throughput generation of phenotypic data on mutant proteins, it has become important to individually characterise different proteins or their variants rapidly and with minimal sample consumption. We have made use of a nano Differential Scanning Fluorimetric device, from NanoTemper technologies, to rapidly carry out isothermal chemical denaturation and measure folding/unfolding kinetics of proteins and compared these to corresponding data obtained from conventional spectrofluorimetry. We show that using sample volumes ten-fifty fold lower than with conventional fluorimetric techniques, one can rapidly and accurately measure thermodynamic and kinetic stability, as well as folding/unfolding kinetics. Read More

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http://dx.doi.org/10.1002/pro.3622DOI Listing

Familial Macro-Aspartate Transaminase - An Unsolved Puzzle?

Indian J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Topiwala National Medical College and BYL Ch Hospital, Dr. A.L Nair Road, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1007/s12098-019-02951-2DOI Listing

Genetic Consultations in the Newborn: Robin D. Clark and Cynthia J. Curry (eds) : Published by Oxford University Press, UK; First Edition: 2019; DOI: 10.1093/med/9780199990993.001.0001; ISBN: 9780199990993.

Authors:
Neerja Gupta

Indian J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Division of Genetics, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

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http://dx.doi.org/10.1007/s12098-019-02947-yDOI Listing

Significance of MMP-9 and VEGF-C expression in North Indian women with breast cancer diagnosis.

Mol Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi, 110095, India.

Metastasis accounts for the majority of cancer-associated mortality and renders the targeted therapy fruitless in the patients of breast cancer. Matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF-C) are thought to be involved in tumor progression and metastasis. The aim of this study was to investigate the expression of MMP-9 and VEGF-C at both mRNA and protein levels in breast cancer and to correlate with lymph node metastasis and other clinicopathological characteristics. Read More

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http://link.springer.com/10.1007/s11010-019-03515-w
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http://dx.doi.org/10.1007/s11010-019-03515-wDOI Listing
April 2019
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