257,246 results match your criteria Indian Journal for the Practising Doctor [Journal]


Testing the gene expression classification of the EMT spectrum.

Phys Biol 2018 Dec 17. Epub 2018 Dec 17.

Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX 77251-1892, USA, Houston, Texas, UNITED STATES.

The epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis and drug resistance - two persistent clinical challenges. Epithelial cells can undergo a partial or full EMT, attaining either a hybrid epithelial/mesenchymal (E/M) or mesenchymal phenotype, respectively. Recent studies have emphasized that hybrid E/M cells may be more aggressive than their mesenchymal counterparts. Read More

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http://dx.doi.org/10.1088/1478-3975/aaf8d4DOI Listing
December 2018

A smart nanosensor for the detection of human immunodeficiency virus and associated cardiovascular and arthritis diseases using functionalized graphene-based transistors.

Biosens Bioelectron 2018 Dec 7;126:792-799. Epub 2018 Dec 7.

DBT-National Institute of Animal Biotechnology (DBT-NIAB), Hyderabad 500032, Telangana, India. Electronic address:

Human immunodeficiency virus (HIV), which isa worldwide public health issue, is commonly associated with cardiovascular disorders (CVDs) and rheumatoid arthritis (RA). A smart nanosensor was developed for the detection of HIV and its related diseases (CVDs and RA) using graphene-based field-effect transistors (FETs). In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers. Read More

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http://dx.doi.org/10.1016/j.bios.2018.11.041DOI Listing
December 2018

Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.

Environ Pollut 2018 Dec 5;246:311-318. Epub 2018 Dec 5.

Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain.

Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793).

Methods: Urine metal concentrations were measured using ICP-MS. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.010DOI Listing
December 2018

Genome-wide association mapping of spot blotch resistance in wheat association mapping initiative (WAMI) panel of spring wheat (Triticum aestivum L.).

PLoS One 2018 17;13(12):e0208196. Epub 2018 Dec 17.

International Maize and Wheat Improvement Center (CIMMYT), DPS Marg, New Delhi, India.

Spot blotch (SB) caused by Bipolaris sorokiniana, is one of the most important diseases of wheat in the eastern part of south Asia causing considerable yield loss to the wheat crop. There is an urgent need to identify genetic loci closely associated with resistance to this pathogen for developing resistant cultivars. Hence, genomic regions responsible for SB resistance were searched using a wheat association mapping initiative (WAMI) panel involving 287 spring wheat genotypes of different origin. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208196PLOS
December 2018
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Microbial community composition and diversity in the Indian Ocean deep sea REY-rich muds.

PLoS One 2018 17;13(12):e0208230. Epub 2018 Dec 17.

Key Lab of Marine Bioactive Substances of SOA, The First Institute of Oceanography, Qingdao, China.

Studies about the composition and diversity of microbial community in the Rare Earth Elements-rich muds are limited. In this research, we conducted a characterization for the composition and diversity of bacterial and archaeal communities from rare earth elements-rich gravity core sediment at approximately 4800 meters deep in the Indian Ocean by Illumina high-throughput sequencing targeting 16S rRNA genes. The results showed that the most abundant bacteria were Proteobacteria, followed by Firmicutes and Actinobacteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208230PLOS
December 2018

Correlation of Cell-Surface CD8 Levels with Function, Phenotype and Transcriptome of Naive CD8 T Cells.

Immunology 2018 Dec 17. Epub 2018 Dec 17.

National Institute of Immunology, New Delhi, India.

We have previously demonstrated co-receptor level-associated functional heterogeneity in apparently homogenous naive peripheral CD4 T cells, dependent on MHC-mediated tonic signals. Since maturation pathways can differ between naive CD4 and naive CD8 cells, we tested whether the latter showed similar co-receptor level-associated functional heterogeneity. We report that, when either polyclonal and TCR-transgenic monoclonal peripheral naive CD8 T cells from young mice were separated into CD8hi and CD8lo subsets, CD8lo cells responded poorly, but CD8hi and CD8lo subsets of CD8 single-positive (SP) thymocytes responded similarly. Read More

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http://doi.wiley.com/10.1111/imm.13036
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http://dx.doi.org/10.1111/imm.13036DOI Listing
December 2018
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Proteomic analysis and antivenomics study of Western India Naja naja venom: Correlation between venom composition and clinical manifestations of cobra bite in this region.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology , Tezpur University , Tezpur 784028 , Assam , India.

Background: Snakebite is a severe problem in the tropical countries including Indian subcontinent. Premier cases of cobra bites are being reported from western India (WI).

Research Design And Methods: The proteome of WI N. Read More

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http://dx.doi.org/10.1080/14789450.2019.1559735DOI Listing
December 2018

Metal-Helix Frameworks from Short Hybrid Peptide Foldamers.

Angew Chem Int Ed Engl 2018 Dec 17. Epub 2018 Dec 17.

Indian Institute of Science Education and Research, Department of Chemistry, Dr. Homi Bhabha Road, 411008, Pune, INDIA.

The potential of structured peptides has not been explored much in the design of metal-organic-frameworks (MOFs). This is partly due to the difficulties in obtaining stable secondary structures from the short α-peptide sequences. Here we report the design, crystal conformations, coordination site dependent different silver coordinated frameworks of short α,γ-hybrid peptide 12-helices consisting of terminal pyridyl moieties and the utility of metal-helix frameworks in the adsorption of CO2. Read More

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http://dx.doi.org/10.1002/anie.201810849DOI Listing
December 2018

Gold-catalysed regioselective cascade cycloisomerisation reactions of aza-enediynes for the synthesis of substituted benzoisoquinoline derivatives.

Org Biomol Chem 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Central University of Haryana, Mahendergarh, Haryana 123 031, India.

Aza-enediynes underwent a facile, regioselective gold-catalysed cascade cycloisomerisation to furnish dihydrobenzo[f]isoquinoline derivatives in excellent yields. The aza-enediynes were conveniently prepared via a formal vinylic displacement reaction of allyl bromosulfones. The latter functioned as a stable and easily accessible synthetic equivalent of allenyl sulfone. Read More

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http://dx.doi.org/10.1039/c8ob02544dDOI Listing
December 2018

A new DNA sensor system for specific and quantitative detection of mycobacteria.

Nanoscale 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.

In the current study, we describe a novel DNA sensor system for specific and quantitative detection of mycobacteria, which is the causative agent of tuberculosis. Detection is achieved by using the enzymatic activity of the mycobacterial encoded enzyme topoisomerase IA (TOP1A) as a biomarker. The presented work is the first to describe how the catalytic activities of a member of the type IA family of topoisomerases can be exploited for specific detection of bacteria. Read More

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http://xlink.rsc.org/?DOI=C8NR07850E
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http://dx.doi.org/10.1039/c8nr07850eDOI Listing
December 2018
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Moving Toward Openness: Blackfeet Indians' Perception Changes Regarding Talking About End of Life.

Am J Hosp Palliat Care 2018 Dec 16:1049909118818255. Epub 2018 Dec 16.

2 Eagle Shield Center, Blackfeet Nation, Browning, MT, USA.

This study was conducted to examine cultural appropriateness and readiness for the Blackfeet people in the United States talking about end of life. In the past, a taboo perception of Blackfeet traditional belief in end-of-life discussion was identified as a core barrier for hospice use. However, a recent anecdotal increase in hospice interest triggered the research team to investigate community-wide interest as well as traditional appropriateness of hospice introduction. Read More

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http://dx.doi.org/10.1177/1049909118818255DOI Listing
December 2018
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Influence of glycerol on the cooling effect of pair hydrophobicity in water: relevance to proteins' stabilization at low temperature.

Phys Chem Chem Phys 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Indian Institute of Technology Patna, Bihar 801106, India.

Glycerol, as a cosolvent of water, stabilizes proteins under extreme conditions (both at high and low temperatures). However, the mechanism of stabilization of proteins by glycerol at low temperature is still elusive. Because the decrease of hydrophobic interactions at a lower temperature is one of the crucial factors for the cold denaturation, we ask here whether glycerol protects the hydrophobic interactions upon cooling and thereby acts against cold denaturation. Read More

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http://dx.doi.org/10.1039/c8cp06513fDOI Listing
December 2018

Spectroscopic and magnetic investigations of a spin-frustrated Mn-doped CoAlO spinel.

Phys Chem Chem Phys 2018 Dec 17. Epub 2018 Dec 17.

School of Materials Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

Single-phase polycrystalline spin-frustrated spinel oxides Co1-xMnxAl2O4 (0 ≤ x ≤ 0.3) have been prepared to investigate the optical and magnetic properties. Linear variation of the lattice parameter along with the characteristic hyperfine electron paramagnetic resonance (EPR) signal establish the fact that the Mn2+ ions are incorporated at Co2+ sites of the CoAl2O4 lattice. Read More

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http://dx.doi.org/10.1039/c8cp07140cDOI Listing
December 2018

Synthesis of Triazole-Substituted Quinazoline Hybrids for Anticancer Activity and a Lead Compound as the EGFR Blocker and ROS Inducer Agent.

ACS Omega 2018 Nov 28;3(11):16134-16142. Epub 2018 Nov 28.

Organic & Medicinal Chemistry Division, Academy of Scientific and Innovative Research (AcSIR), and Cancer Biology & Inflammatory Disorder, Indian Institute of Chemical Biology (CSIR-IICB), 4 Raja S. C. Mullick Road, Kolkata 700032, India.

A series of triazole-substituted quinazoline hybrid compounds were designed and synthesized for anticancer activity targeting epidermal growth factor receptor (EGFR) tyrosine kinase. Most of the compounds showed moderate to good antiproliferative activity against four cancer cell lines (HepG2, HCT116, MCF-7, and PC-3). Compound showed good antiproliferative activity (IC = 20. Read More

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http://dx.doi.org/10.1021/acsomega.8b01960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288807PMC
November 2018

Clickable PNA Probes for Imaging Human Telomeres and Poly(A) RNAs.

ACS Omega 2018 Nov 12;3(11):15343-15352. Epub 2018 Nov 12.

Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Doctor Homi Bhabha Road, Pune 411008, India.

The ability to bind strongly to complementary nucleic acid sequences, invade complex nucleic acid structures, and resist degradation by cellular enzymes has made peptide nucleic acid (PNA) oligomers as very useful hybridization probes in molecular diagnosis. For such applications, the PNA oligomers have to be labeled with appropriate reporters as they lack intrinsic labels that can be used in biophysical assays. Although solid-phase synthesis is commonly used to attach reporters onto PNA, development of milder and modular labeling methods will provide access to PNA oligomers labeled with a wider range of biophysical tags. Read More

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http://dx.doi.org/10.1021/acsomega.8b02550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289544PMC
November 2018

Can microRNA profiles predict corticosteroid responsiveness in childhood nephrotic syndrome? A study protocol.

BMJ Paediatr Open 2018 17;2(1):e000319. Epub 2018 Nov 17.

Department of Pediatric Nephrology, Armed Forces Medical College, Pune, Maharashtra, India.

Introduction: In last few years, several studies have revealed the remarkable stability of extracellular microRNAs (miRNAs) circulating in the blood or excreted in the urine and underscored their key importance as biomarkers of certain diseases. Since miRNA in urinary sediment is relatively stable and easily quantified, it has the potential to be developed as a biomarker for disease diagnosis and monitoring. Identification of serum and urinary levels of certain miRNAs may assist in the diagnosis and assessment of disease activity in patients with nephrotic syndrome (NS). Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267312PMC
November 2018

Secular decrease of wind power potential in India associated with warming in the Indian Ocean.

Sci Adv 2018 Dec 5;4(12):eaat5256. Epub 2018 Dec 5.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

The Indian government has set an ambitious target for future renewable power generation, including 60 GW of cumulative wind power capacity by 2022. However, the benefits of these substantial investments are vulnerable to the changing climate. On the basis of hourly wind data from an assimilated meteorology reanalysis dataset covering the 1980-2016 period, we show that wind power potential may have declined secularly over this interval, particularly in western India. Read More

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http://dx.doi.org/10.1126/sciadv.aat5256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292784PMC
December 2018

Biochemical Characterization of Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer.

Front Bioeng Biotechnol 2018 29;6:180. Epub 2018 Nov 29.

Microbial Type Culture Collection and Gene Bank, CSIR-Institute of Microbial Technology, Chandigarh, India.

Excess amounts of uric acid in humans leads to hyperuricemia, which is a biochemical precursor of gout and is also associated with various other disorders. Gout is termed as crystallization of uric acid, predominantly within joints. The burden of hyperuricemia and gout has increased worldwide due to lifestyle changes, obesity, and consumption of purine-rich foods, fructose-containing drinks, and alcoholic beverages. Read More

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http://dx.doi.org/10.3389/fbioe.2018.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281700PMC
November 2018

Molecular analysis of mutant () gene in diverse waxy maize inbreds.

3 Biotech 2019 Jan 11;9(1). Epub 2018 Dec 11.

1ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, 110012 India.

Waxy corn is popular beacuse of its high amylopectin due to mutation in or () gene. Here, we characterized the allele among 24 diverse waxy inbreds using gene-based markers. A total of 29 alleles with average of 1. Read More

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http://link.springer.com/10.1007/s13205-018-1530-6
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http://dx.doi.org/10.1007/s13205-018-1530-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289911PMC
January 2019
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Alarming levels of antimicrobial resistance among sepsis patients admitted to ICU in a tertiary care hospital in India - a case control retrospective study.

Antimicrob Resist Infect Control 2018 7;7:150. Epub 2018 Dec 7.

1Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi, 110007 India.

Background: Hospital acquired infections (HAI) are principal threats to the patients of intensive care units. An increase in the antimicrobial resistance (AMR) observed in gram negative bacteria is a great challenge to deal with. HAI and AMR lead to prolonged hospitalization and additional doses of anti-microbial treatment affecting patient's fitness and finances. Read More

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http://dx.doi.org/10.1186/s13756-018-0444-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286518PMC
December 2018

Germline and deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India.

Cancer Manag Res 2018 30;10:6505-6516. Epub 2018 Nov 30.

Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110085, India.

Background: The spectrum of BRCA mutations that predispose to development of breast/ovarian cancer in Indian population remains unexplored. We report incidence and various types of pathogenic, likely pathogenic and variants of unknown significance (VUS) mutations in and genes observed at a tertiary cancer center in North India.

Materials And Methods: A total of 206 unrelated breast and/or ovarian cancer patients, who met the National Comprehensive Cancer Network (NCCN) guidelines for genetic testing, were screened for germline / mutations on high-throughput sequencing platform; large genomic rearrangements were assessed by multiple ligation probe assay. Read More

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http://dx.doi.org/10.2147/CMAR.S186563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280886PMC
November 2018

Genetics of ulcerative colitis: putting into perspective the incremental gains from Indian studies.

J Genet 2018 Dec;97(5):1493-1507

School of Biotechnology, Jawaharlal Nehru University, New Delhi 110 067, India.

Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies have revealed shared as well as unique disease susceptibly signaturesbetween them, pointing to population specific differences at genomic and environmental levels. A systematic recount of the four major eras in UC genetics spanning earliest linkage analysis, cherry picked candidate gene association studies, unbiased genomewide association studies, their logical extension in trans-ethnic setting (Immunochip study), lastly whole exome sequencing efforts forrare variant burden; and lessons learnt thereof in context of genetically distinct Indian population was attempted in this review. Read More

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December 2018
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Noninvasive DNA-based species and sex identification of Asiatic wild dog ().

J Genet 2018 Dec;97(5):1457-1461

Wildlife Institute of India, Chandrabani, Dehradun 248 001, India.

Asiatic wild dog () or dhole is an endangered canid with fragmented distribution in South, East and Southeast Asia. The remaining populations of this species face severe conservation challenges from anthropogenic interventions, but only limited information is available at population and demography levels. Here, we describe the novel molecular approaches for unambiguous species and sex identification from noninvasively collected dhole samples. Read More

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December 2018

A novel study to examine the association of rs505151 polymorphism and coronary artery disease in north Indian population.

J Genet 2018 Dec;97(5):1371-1378

Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.

There is a drastic increase in the number of people suffering from coronary artery disease (CAD) worldwide with Indians being no exception. Being a developing country and experiencing a dramatic shift in lifestyle and eating habits, urbanization and industrialization, all these factors have collectively predisposed the Indian population towards CAD and the prevalence data arequite alarming. Genetic studies have disclosed the role of genes in CAD susceptibility and severity. Read More

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December 2018

Establishment of base population for selective breeding of catla () depending on phenotypic and microsatellite marker information.

J Genet 2018 Dec;97(5):1327-1337

Fish Genetics and Biotechnology Division, ICAR-Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751 002, India.

The phenotypic and microsatellite marker information of nine strains of catla () for growth trait was used to infer relationship within and between strains. This information helped in optimizing the proportion of individuals to be used from each strain while creating a base population for selective breeding. For this purpose, nine strains were collected from different sources and places of India namely West Bengal, Bihar, Odisha, Andhra Pradesh and Uttar Pradesh. Read More

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December 2018

Complex effects of Ayurvedic formulation: and on different components of life history may elude the elixir effect.

J Genet 2018 Dec;97(5):1253-1261

Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India.

Formulations from the traditional Indian medicine, Ayurveda, have long been considered to have potent life-style enhancing effects, possibly by their effect(s) on key life-history attributes. Although several studies have reported beneficial effects of these formulations on different components of life history, few have investigated their concurrent influence on various life-history traits. Here, we report the results of an investigation showing the effect of two well-known Ayurvedic formulations, and , on fecundity and longevity of . Read More

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December 2018

Phylogenetic analysis and evolution of morphological characters in the genus L. (Oleaceae) in India.

J Genet 2018 Dec;97(5):1225-1239

Department of Botany, Fatima Mata National College (Autonomous), Kollam 691 001, India.

L. (Oleaceae) consists of ∼200 species that are distributed in tropical, subtropical and temperate regions of the world. In India, this genus is represented by ca 47 species of which 16 are endemic. Read More

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December 2018

Ultrasound-assisted biodiesel production using heterogeneous base catalyst and mixed non-edible oils.

Ultrason Sonochem 2018 Dec 4. Epub 2018 Dec 4.

Center for Energy, Indian Institute of Technology Guwahati, Assam 781 039, India; Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam 781 039, India. Electronic address:

In the present study, the ultrasound-assisted biodiesel production from mixed feedstock of non-edible oils in presence of KI impregnated ZnO as a catalyst in batch reactor was investigated. The production was optimized by using two approaches (1) feedstock optimization and (2) process parameters optimization. Various non-edible oils at optimum volumetric ratio were blended and used as feedstock for transesterification reaction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13504177183113
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http://dx.doi.org/10.1016/j.ultsonch.2018.11.021DOI Listing
December 2018
1 Read

'Recognized journals' in guidelines from Central Council of Indian Medicine on research publications needs specification.

J Ayurveda Integr Med 2018 Dec 13. Epub 2018 Dec 13.

ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.jaim.2018.10.001DOI Listing
December 2018

Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells.

Stem Cell Reports 2018 Dec 10. Epub 2018 Dec 10.

National Centre for Cell Science, SP Pune University, Ganeshkhind, Pune 411007, India. Electronic address:

Endocytosis is implicated in the maintenance of embryonic stem cell (ESC) pluripotency, although its exact role and the identity of molecular players remain poorly understood. Here, we show that the clathrin heavy chain (CLTC), involved in clathrin-mediated endocytosis (CME), is vital for maintaining mouse ESC (mESC) pluripotency. Knockdown of Cltc resulted in a loss of pluripotency accompanied by reduced E-cadherin (E-CAD) levels and increased levels of transforming growth factor β (TGF-β) and extracellular signal-regulated kinase (ERK) signaling. Read More

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http://dx.doi.org/10.1016/j.stemcr.2018.11.018DOI Listing
December 2018

Hypophosphataemia in severe acute malnutrition: a prospective observational study.

Br J Nutr 2018 Dec 17:1-6. Epub 2018 Dec 17.

1Department of Paediatrics,King George's Medical University,Lucknow,Uttar Pradesh,226003,India.

Severe acute malnutrition (SAM) is a major cause of child mortality and morbidity. Children treated for SAM are at risk of refeeding hypophosphataemia (HP). The study was done to find out the incidence and various predictors of moderate/severe HP in SAM among North Indian children. Read More

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http://dx.doi.org/10.1017/S0007114518003197DOI Listing
December 2018

Dietary Patterns and Anthropometric Measures of Indian Children with Autism Spectrum Disorder.

J Autism Dev Disord 2018 Dec 15. Epub 2018 Dec 15.

Department of Studies in Food Science and Nutrition, University of Mysore, Mysuru, India.

Research literature on dietary patterns & eating habits of children with Autism Spectrum Disorder (ASD) in India is limited. To explore this, a pilot study (n = 53) which included 45 boys and 8 girls (age group of 2-13 years) was conducted. Three day food records, Food Frequency Questionnaire and Children Eating Behavior Inventory were used to assess the dietary intakes and mealtime behavior problems respectively. Read More

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http://dx.doi.org/10.1007/s10803-018-3850-0DOI Listing
December 2018

Impact of India's National Tobacco Control Programme on bidi and cigarette consumption: a difference-in-differences analysis.

Tob Control 2018 Dec 15. Epub 2018 Dec 15.

Health Promotion Division, Public Health Foundation of India, Gurugram, India.

Background: Despite the importance of decreasing tobacco use to achieve mortality reduction targets of the Sustainable Development Goals in low-income and middle-income countries (LMICs), evaluations of tobacco control programmes in these settings are scarce. We assessed the impacts of India's National Tobacco Control Programme (NTCP), as implemented in 42 districts during 2007-2009, on household-reported consumption of bidis and cigarettes.

Methods: Secondary analysis of cross-sectional data from nationally representative Household Consumer Expenditure Surveys (1999-2000; 2004-2005 and 2011-2012). Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054621DOI Listing
December 2018
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Simultaneous detection of ATP metabolites in human plasma and urine based on palladium nanoparticle and poly(bromocresol green) composite sensor.

Biosens Bioelectron 2018 Dec 8;126:758-766. Epub 2018 Dec 8.

Department of Chemistry and Institute of BioPhysio Sensor Technology (IBST), Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes. The linear calibration curves were obtained in the concentration range of 0. Read More

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http://dx.doi.org/10.1016/j.bios.2018.11.056DOI Listing
December 2018
1 Read

ng inputs that may arise from the field Decision tool for climate disasters and infectious disease at sub-national level in India: Ensuring a paradigm shift in health planning from prevalence to vulnerability.

Acta Trop 2018 Dec 13. Epub 2018 Dec 13.

Indian Institute of Public Administration, Delhi, India.

Climate change is considered as a distal determinant of public health which is increasing in importance. India, as an example, has a national action plan for climate change and human health. Sub-national (State) plans for climate change also exist, taking into account the health sector. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.006DOI Listing
December 2018
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Microwave assisted κ-carrageenan capped silver nanocomposites for eradication of bacterial biofilms.

Carbohydr Polym 2019 Feb 14;206:854-862. Epub 2018 Nov 14.

Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:

Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183136
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http://dx.doi.org/10.1016/j.carbpol.2018.11.033DOI Listing
February 2019
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Immobilization of hyaluronic acid from Lactococcus lactis on polyethylene terephthalate for improved biocompatibility and drug release.

Carbohydr Polym 2019 Feb 31;206:132-140. Epub 2018 Oct 31.

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address:

Hyaluronic acid from metabolically engineered Lactococcus lactis (HA) was characterized for its biocompatibility and immobilized on the polyethylene terephthalate (PET) surface. HA was chemically crosslinked on hydrolyzed PET (hPET) surface to form HA-coated PET (hPET-HA). The unmodified and modified PET were characterized by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), contact angle measurement, thermogravimetric analysis (TGA), universal testing machine (UTM) and assessed for their biocompatibility. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.10.099DOI Listing
February 2019

Synthesis of fly ash based zeolite-reduced graphene oxide composite and its evaluation as an adsorbent for arsenic removal.

Chemosphere 2018 Dec 4;219:504-509. Epub 2018 Dec 4.

School of Engineering, Indian Institute of Technology, Mandi, 175005, Himachal Pradesh, India. Electronic address:

A zeolite-reduced graphene oxide (ZrGO) based composite was synthesized to remove arsenic from water. To make a low-cost adsorbent, zeolite was synthesized using an inexpensive waste material; fly ash, which was further used to produce the ZrGO composite. Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Raman spectra were used to characterize the morphology and surface composition of the synthesized materials. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.203DOI Listing
December 2018
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Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.12.010DOI Listing
December 2018

Effects of foliar application of zinc sulfate and zinc nanoparticles in coffee (Coffea arabica L.) plants.

Plant Physiol Biochem 2018 Dec 10;135:160-166. Epub 2018 Dec 10.

Department of Horticultural Sciences and Center for Coffee Research & Education, Texas A&M University, TAMU 2133, College Station, TX, 77843, USA.

A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO ‧ HO) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428183054
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http://dx.doi.org/10.1016/j.plaphy.2018.12.005DOI Listing
December 2018
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Binding of norharmane with RNA reveals two thermodynamically different binding modes with opposing heat capacity changes.

J Colloid Interface Sci 2018 Dec 4;538:587-596. Epub 2018 Dec 4.

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 426066, Madhya Pradesh, India. Electronic address:

The binding interaction of a prospective anti-cancer photosensitizer, norharmane (NHM, 9H-pyrido[3,4-b]indole) with double stranded RNA reveals a primarily intercalative mode of binding. Steady-state and time-resolved fluorescence spectroscopic results demonstrate the occurrence of drug-RNA binding interaction as manifested through environment-sensitive prototropic equilibrium of NHM. However, the key finding of the present study lies in unraveling the complexities in the NHM-RNA binding thermodynamics. Read More

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http://dx.doi.org/10.1016/j.jcis.2018.12.011DOI Listing
December 2018
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Evaluation of antioxidant and antimicrobial potential of a novel Himalayan plant Reinwardtia indica dumort: Scientifically unexplored.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Department of Kriyasharir Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Reinwardtia indica (Lineceae) is a medicinal plant cultivated in the Himalayan region. It is effectively used in folk medicines for the treatment of various health complications. In the present study, the shade dried leaves and stem were extracted in three different solvents such as ethyl acetate, ethanol, and hydro-alcoholic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183006
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http://dx.doi.org/10.1016/j.micpath.2018.12.024DOI Listing
December 2018
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Novel predators and anthropogenic disturbance influence spatio-temporal distribution of forest antelope species.

Behav Processes 2018 Dec 12. Epub 2018 Dec 12.

School of Life Sciences, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address:

Understanding the effects of anthropogenic disturbance on species' behaviour is crucial for conservation planning, considering the extent of habitat loss. We investigated the influence of anthropogenic disturbances including agriculture, urbanisation, protected areas, and the presence of novel predators, on the temporal and spatial behaviour of sympatric forest antelope (Tragelaphus scriptus, Philantomba monticola, Sylvicapra grimmia, and Cephalophus natalensis) in an anthropogenic matrix containing forest fragments in the Indian Ocean Coastal Belt of South Africa. We integrated land-use types with camera-trap data and compared activity patterns using circular statistics and occupancy modelling. Read More

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http://dx.doi.org/10.1016/j.beproc.2018.12.005DOI Listing
December 2018

LeishInDB: a web-accessible resource for small molecule inhibitors against Leishmania sp.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007. India.

Despite the availability of drugs to treat Leishmaniasis, various other factors including drug resistance and adverse side effects encourage the researchers to search for new strategies and alternatives for treating Leishmaniasis. Repurposing and devising combination therapy with the existing small molecules would serve as an alternative strategy to address the issue, especially the drug resistance. Hence, here we report LeishInDB, a web-accessible resource of small molecule inhibitors having a varying degree of activity towards Leishmania sp. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183140
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http://dx.doi.org/10.1016/j.actatropica.2018.12.022DOI Listing
December 2018
1 Read
2.270 Impact Factor

TiS2 Monolayer Emerging as Ultrathin Bifunctional Catalyst: Influence of Defect and Functionalization.

Chemphyschem 2018 Dec 15. Epub 2018 Dec 15.

Department of Materials Science, Indian Association for the Cultivation of Science,Jadavpur, Kolkata-700032,India., INDIA.

We have envisaged the hydrogen evolution and oxygen evolution reaction (HER and OER) on two-dimensional (2D) noble metal free titanium disulfide TiS2 monolayer, which belongs to the exciting family of transition metal dichalcogenides (TMDCs). Our theoretical investigation to probe HER and OER on both H- and T- phase of 2D TiS2 is based on the electronic structure calculations witihin the framework of Density Functional Theory (DFT). Since TiS2 is the lightest element among the group IV transition metal dichalocogenides, it is worth exploring the catalytic activity of TiS2 monolayer through the functionalization at the anion (S) site substituting with P, N and C dopants as well as by incorporating single sulfur vacancy defect. Read More

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http://dx.doi.org/10.1002/cphc.201801031DOI Listing
December 2018

Process Analytical Technology Implementation for Protein Refolding: GCSF as a Case Study.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.

Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.26900
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http://dx.doi.org/10.1002/bit.26900DOI Listing
December 2018
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Renaming of 'Candidatus Methylocucumis oryzae' as Methylocucumis oryzae gen. nov., sp. nov., a novel Type I methanotroph isolated from India.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

MACS Agharkar Research Institute, G.G. Agarkar Road, Pune, 411004, Maharashtra, India.

Candidatus Methylocucumis (Mcu.) oryzae, strain Sn10-6, a Gram-negative, pale pink pigmented, motile, large Type I methanotroph (3-6 µm × 1.5-2 µm) was recently isolated from an Indian rice field. Read More

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http://dx.doi.org/10.1007/s10482-018-01218-8DOI Listing
December 2018

Correction to: Current scenario and future strategies to fight artemisinin resistance.

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Malaria Research, Dwarka Sector 8, New Delhi, 110077, India.

Author Atul Yadav would like to present his name as Atul only to be the same with his previous publications. The original article has been corrected. Read More

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http://dx.doi.org/10.1007/s00436-018-6175-1DOI Listing
December 2018

Comparative metabolomics of scab-resistant and susceptible apple cell cultures in response to scab fungus elicitor treatment.

Sci Rep 2018 Dec 14;8(1):17844. Epub 2018 Dec 14.

Plant Molecular Biology Group, Biotechnology Department, Indian Institute of Technology Roorkee, Roorkee, 247667, India.

Apple scab disease caused by the fungus Venturia inaequalis is a devastating disease that seriously affects quality and yield of apples. In order to understand the mechanisms involved in scab resistance, we performed gas chromatography-mass spectrometry based metabolomics analysis of the cell culture of scab resistant cultivar 'Florina' and scab susceptible cultivar 'Vista Bella' both prior -to and -following treatment with V. inaequalis elicitor (VIE). Read More

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http://www.nature.com/articles/s41598-018-36237-y
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http://dx.doi.org/10.1038/s41598-018-36237-yDOI Listing
December 2018
2 Reads

Policy environment impacting the societal harm caused by alcohol in India: protocol for a scoping review.

BMJ Open 2018 Dec 14;8(12):e020854. Epub 2018 Dec 14.

Addictions Research Group, Sangath, Porvorim, Goa, India.

Introduction: The aim of this review is to provide the first consolidation of the policy environment surrounding alcohol-related societal harm in India giving researchers and policy-makers a clearer base for future reforms. This review is also an important adaptation on the scoping review method for policy reviews in low-resource settings that may serve as an example for other policy reviews in similar settings.

Methods And Analysis: We will undertake a scoping review with policy relevant adaptations in order to map the alcohol-related policy environment in India. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-020854DOI Listing
December 2018