Trends Mol Med 2017 Nov 8. Epub 2017 Nov 8.
Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany. Electronic address:
The nuclear factor (NF)-κB essential modulator (NEMO) is a key regulator in NF-κB-mediated signaling. By transmitting extracellular or intracellular signals, NEMO can control NF-κB-regulated genes. NEMO dysfunction is associated with inherited diseases such as incontinentia pigmenti (IP), ectodermal dysplasia, anhidrotic, with immunodeficiency (EDA-ID), and some cancers. Read More