684,088 results match your criteria In Vivo International Journal of Experimental and Clinical Pathophysiology and Drug Research[Journal]


A clinical multi-center registry study on digital nerve repair using a biodegradable nerve conduit of PGA with external and internal collagen scaffolding.

Microsurgery 2018 Dec 18. Epub 2018 Dec 18.

Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Kindai University, Osakasayama, Japan.

Background: In this study, we evaluated the clinical efficacy of a biodegradable nerve conduit constructed of polyglycolic acid (PGA) tube with external and internal collagen scaffolding for digital nerve repair.

Patients And Methods: A multi-center registry study was conducted in 11 locations between July 2013 and May 2016. Multiple mechanisms of injury included clean-cut (12 patients), crush (5 patients), and avulsion (3 patients) types of injuries. Read More

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http://dx.doi.org/10.1002/micr.30417DOI Listing
December 2018

[Physicians of Gladiators in the Ancient Rome].

Dtsch Med Wochenschr 2018 Dec 18;143(25):1842-1846. Epub 2018 Dec 18.

Gladiators in ancient Rome were an integral part of the Roman world and were a unique phenomenon. Their bloody fight presumably originated from the cult of the dead. Later it was a feature of the self-portrayal of many Roman noblemen, especially during the election campaigns. Read More

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http://dx.doi.org/10.1055/a-0601-0440DOI Listing
December 2018

[Immunometabolism and systemic lupus erythematosus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1120-1124

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease, characterized by production of pathogenic autoantibodies and wide involvement of multiple systems. Damageofimmune tolerance and imbalance of immune homeostasis lead to the production of autoantibodies and the injuries of multiple organs and systems. In recent years, plenty of studies have identified that immunometabolism affects survival status of certain cells, also cell activation, differentiation and effector functions. Read More

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December 2018

Avulsion fracture of anterior talofibular ligament from talus: A case report.

Foot (Edinb) 2018 Dec 5;38:24-29. Epub 2018 Dec 5.

Antalya Education and Research Hospital, Department of Orthopaedics and Traumatology, Antalya, Turkey. Electronic address:

Anterior talofibular ligament (ATFL) injuries can occur in three different distinct patterns; rupture of the ligament as a pure soft tissue injury, an avulsion fracture at the ATFL's attachment to the either fibula or talus. Although fibular avulsion fractures are common, avulsion fracture of ATFL from talus is extremely rare with a single previously reported case in current literature. A 34-year-old female with ATFL talar avulsion fracture associated with medial malleolar fracture was presented to ED. Read More

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http://dx.doi.org/10.1016/j.foot.2018.12.002DOI Listing
December 2018

Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses.

Regul Toxicol Pharmacol 2018 Dec 15. Epub 2018 Dec 15.

Leadscope, Inc., 1393 Dublin Rd, Columbus, OH, 43215, USA. Electronic address:

The International Council for Harmonization (ICH) M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product. In the absence of adequate experimental bacterial mutagenicity data, (Q)SAR analysis may be used as a test to predict impurities' DNA reactive (mutagenic) potential. However, in certain situations, (Q)SAR software is unable to generate a positive or negative prediction either because of conflicting information or because the impurity is outside the applicability domain of the model. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.12.007DOI Listing
December 2018

Outcomes after Single-Look Trauma Laparotomy: A Large Population-Based Study.

J Trauma Acute Care Surg 2018 Dec 18. Epub 2018 Dec 18.

Trauma Service, Scripps Mercy Hospital, San Diego, California.

Background: Outcomes following damage control laparotomy for trauma have been studied in detail. However, outcomes following a single operation, or "single-look trauma laparotomy" (SLTL), have not. We evaluated the association between SLTL and both short-term and long-term outcomes in a large, population-based dataset. Read More

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http://dx.doi.org/10.1097/TA.0000000000002167DOI Listing
December 2018

Effectiveness of the Taut-Line Hitch Knot in Reducing and Splinting Lower Extremity Fractures.

J Orthop Trauma 2019 Jan;33(1):e31-e35

Department of Orthopaedics, University of Cincinnati, Cincinnati, OH.

Techniques for single-provider reductions are valuable methods for provisional stabilization of fractures. In the setting of a lower extremity fracture, these techniques often use stockinette or kerlex to suspend an extremity while a reduction maneuver is performed, cast padding is applied, and a plaster splint is placed with subsequent molding to maintain reduction. Obtaining and maintaining a suitable amount of tension to the soft material while securing the limb to the stretcher or hospital bed continues to make these reduction maneuvers difficult to perform. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001315DOI Listing
January 2019

Surgical Management of Multiple Rib Fractures Reduces the Hospital Length of Stay and the Mortality Rate in Major Trauma Patients: A Comparative Study in a UK Major Trauma Center.

J Orthop Trauma 2019 Jan;33(1):9-14

Department of Trauma and Orthopaedics, Aintree University Hospital, Liverpool, United Kingdom.

Objectives: To investigate and assess the effectiveness of surgical fixation of rib fractures in complex traumatic chest injuries compared with traditional nonoperative management.

Design: Retrospective observational comparative study.

Setting: Level 1 Major Trauma Centre in North West England. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001264DOI Listing
January 2019

Penile cancer epidemiology and risk factors: a contemporary review.

Curr Opin Urol 2018 Dec 17. Epub 2018 Dec 17.

Department of Urology, Indiana University Medical Center, Indianapolis, IN, USA.

Purpose Of Review: Our objective is to present an overview of epidemiologic, clinical, and molecular risk factors with a focus on contemporary literature.

Recent Findings: Penile cancer is a rare and aggressive neoplasm that accounts for less than 1% of male malignancies in the United States. Geographical disparities in incidence of disease are evident with high rates concentrated in the developing world (2. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000581DOI Listing
December 2018

Randomized Controlled Trial Evaluating Aerobic Training and Common Sport-Related Concussion Outcomes in Healthy Participants.

J Athl Train 2018 Dec 18. Epub 2018 Dec 18.

Department of Exercise and Sport Science, University of North Carolina at Chapel Hill.

Context: Aerobic exercise interventions are increasingly being prescribed for concussion rehabilitation, but whether aerobic training protocols influence clinical concussion diagnosis and management assessments is unknown.

Objectives: To investigate the effects of a brief aerobic exercise intervention on clinical concussion outcomes in healthy, active participants.

Design: Randomized controlled clinical trial. Read More

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http://natajournals.org/doi/10.4085/1062-6050-7-18
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http://dx.doi.org/10.4085/1062-6050-7-18DOI Listing
December 2018
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Assessing the Efficacy of Bacillus thuringiensis (Bt) Pyramided Proteins Cry1F, Cry1A.105, Cry2Ab2, and Vip3Aa20 Expressed in Bt Maize Against Lepidopteran Pests in Brazil.

J Econ Entomol 2018 Dec 17. Epub 2018 Dec 17.

Dow AgroSciences LLC, Indianapolis, IN.

Field studies across four states in maize-producing areas of Brazil were conducted to characterize the efficacy of a new pyramided Bacillus thuringiensis (Bt) Berliner technology in maize, Zea mays L., and compare it to existing single and pyramided commercial Bt technologies, to control Helicoverpa zea Boddie (Lepidoptera: Noctuidae), Elasmopalpus lignosellus Zeller (Lepidoptera: Pyralidae), Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae), and Diatraea saccharalis F. (Lepidoptera: Crambidae). Read More

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http://dx.doi.org/10.1093/jee/toy380DOI Listing
December 2018

Evaluation of the French reactive mortality surveillance system supporting decision making.

Eur J Public Health 2018 Dec 17. Epub 2018 Dec 17.

Santé Publique France, Division for Data Science, Saint-Maurice, France.

Background: In France, a mortality syndromic surveillance system was set up with objectives of early detection and reactive evaluation of the impact of expected and unexpected events to support decision makers. This study aims to describe the characteristics of the system and its usefulness for decision makers.

Methods: Anonymized data from the administrative part of death certificates were daily collected from 3062 computerized city halls and were transmitted to Santé publique France in routine. Read More

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http://dx.doi.org/10.1093/eurpub/cky251DOI Listing
December 2018

lordFAST: sensitive and Fast Alignment Search Tool for LOng noisy Read sequencing Data.

Bioinformatics 2019 Jan;35(1):20-27

Vancouver Prostate Centre, Vancouver, BC, Canada.

Motivation: Recent advances in genomics and precision medicine have been made possible through the application of high throughput sequencing (HTS) to large collections of human genomes. Although HTS technologies have proven their use in cataloging human genome variation, computational analysis of the data they generate is still far from being perfect. The main limitation of Illumina and other popular sequencing technologies is their short read length relative to the lengths of (common) genomic repeats. Read More

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http://dx.doi.org/10.1093/bioinformatics/bty544DOI Listing
January 2019

Inotersen (transthyretin-specific antisense oligonucleotide) for treatment of transthyretin amyloidosis.

Neurodegener Dis Manag 2018 Dec 18. Epub 2018 Dec 18.

Ionis Pharmaceuticals, Carlsbad, CA, USA.

Hereditary  transthyretin amyloidosis (ATTR) is a fatal systemic disease that results from deposition of the misfolded protein transthyretin (TTR) in tissues. Common clinical manifestations of ATTR include peripheral neuropathy, cardiomyopathy, autonomic dysfunction, diarrhea and constipation. Historically there have not been effective therapies for this devastating disease. Read More

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http://dx.doi.org/10.2217/nmt-2018-0037DOI Listing
December 2018

Finding causation in occupational fatalities: A latent class analysis.

Am J Ind Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Epidemiology-ASL TO3, Grugliasco, Torino, Italy.

Background: The method "Learning by mistakes" was developed in Italy to conduct occupational injury investigations and to collect information on the genesis of injuries. The aim is to analyze data classified with this method in order to identify patterns among the factors contributing to injury dynamics.

Methods: Data regarding 673 factors, corresponding to 354 occupational fatalities that occurred in the Piedmont region (north-west of Italy) during 2005-2014 were considered. Read More

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http://dx.doi.org/10.1002/ajim.22936DOI Listing
December 2018

Modified single pedicle reverse adipofascial flap for fingertip reconstruction.

Microsurgery 2018 Dec 17. Epub 2018 Dec 17.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Background: Homodigital adipofascial flap is a well-established method for treating a distal fingertip defect; nonetheless, its use has some limitations. Reconstruction of fingertip injuries, with radial or ulnar tissue loss, may lead to some difficulties in providing an adequate bone coverage. The standard bipedicled technique did not allow the flap to cover the bone exposure without excessive tension. Read More

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http://dx.doi.org/10.1002/micr.30404DOI Listing
December 2018

Using multiple coding schemes for classification and coding of agricultural injury.

Am J Ind Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Biosystems and Agricultural Engineering, University of Kentucky, Lexington, Kentucky.

Background: Agricultural safety and health researchers have used a variety of classification and coding schemes to identify and categorize injury, illness, and disease associated with agricultural hazards. This paper demonstrates how the Farm and Agricultural Injury Classification (FAIC) and Occupational Injury and Illness Classification System (OIICS) coding schemes can be used in tandem for all agricultural injuries.

Methods: Specific cases from the AgInjuryNews. Read More

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http://dx.doi.org/10.1002/ajim.22932DOI Listing
December 2018

Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer.

Laryngoscope 2018 Dec 18. Epub 2018 Dec 18.

Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.

Objective: The purpose of this study was to analyze the outcomes of surgically salvaged early glottic cancer (EGC) recurrences after initial radiotherapy (RT) or transoral laser microsurgery (TLM).

Methods: A matched pair analysis by recurrent tumor-node-metastasis stage (rTNM) considering 27 patients who had TLM as initial treatment and 54 patients who failed after primary RT was performed. Post-recurrence overall and disease-specific survival (DSS) were evaluated. Read More

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http://dx.doi.org/10.1002/lary.27702DOI Listing
December 2018

Targeting the Mycobacterium ulcerans cytochrome bc:aa for the treatment of Buruli ulcer.

Nat Commun 2018 Dec 18;9(1):5370. Epub 2018 Dec 18.

Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Singapore, 636921, Singapore.

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M. Read More

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http://dx.doi.org/10.1038/s41467-018-07804-8DOI Listing
December 2018

[Predicting and preventing the development of post-traumatic gonarthrosis with intra-articular bone fractures of the knee joint].

Khirurgiia (Mosk) 2018 (12):106-110

Department of Traumatology and Orthopedics Kursk State Medical University, Kursk, Russia.

Objective: To develop a program for the prediction and prevention of post-traumatic osteoarthritis of the knee joints.

Material And Methods: For the period 2012-2017. 155 patients were examined in the traumatology departments of the Municipal Hospital No. Read More

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http://dx.doi.org/10.17116/hirurgia2018121106DOI Listing
January 2018

Midfacial fractures: A retrospective etiological study over a 10-year period in Western Romanian population.

Niger J Clin Pract 2018 Dec;21(12):1570-1575

Department of Oral and Maxillofacial Surgery, University of Oradea, Oradea, Romania.

Introduction: Midfacial fractures are extremely important oral and maxillofacial problems because they take varied forms and are frequently accompanied by major long-term esthetic or functional complications. Their etiology and epidemiology vary significantly in the literature, and the main causes are varied by population. The aim of this study is to identify the main traumatic etiology of midfacial fractures, along with the main categories of affected patients in our geographical area, in order to establish the need for measures that can prevent fractures in the future. Read More

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http://dx.doi.org/10.4103/njcp.njcp_256_18DOI Listing
December 2018

Operative Management of Perinatal Lumbar Disc Herniation and Cauda Equina Syndrome: A Case Series

Ir Med J 2018 Dec 6;111(10):843. Epub 2018 Dec 6.

National Spinal Injuries Units, Department of Trauma & Orthopaedic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.

Introduction Perinatal lumbar discectomy for lumbar disc herniation or cauda equina syndrome is a rare clinical scenario. This case series outlines the surgical management of this clinical scenario at a national tertiary referral centre over a 10-year period Methods A retrospective review of all females who underwent discectomy / decompression for lumbar disc herniation or cauda equina syndrome in the perinatal period at a national tertiary referral centre for spine surgery over a 10-year period between January 2008 to December 2017. Results 6 cases required surgical intervention. Read More

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December 2018

Evolution of Veterans Affairs Transcatheter Aortic Valve Replacement Program: The First 100 Patients.

J Heart Valve Dis 2018 Jan;27(1):24-31

Division of Cardiothoracic Surgery, Department of Surgery, University of California San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.

Background: Transcatheter aortic valve replacement (TAVR) is a widely established alternative to surgery in intermediate- and high-risk patients. TAVR program development within the Veterans Affairs (VA) system has been previously described. However, national TAVR registries do not capture VA outcomes data, and few data have been reported regarding TAVR outcomes at lower-volume federal institutions. Read More

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January 2018

Evaluation of a fluidised positioner to reduce occipital pressure injuries in intensive care patients: A pilot study.

Int Wound J 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Health, School of Nursing, Queensland University of Technology and Intensive Care Services, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.

This pilot study aimed to evaluate the clinical efficacy and feasibility of a fluidised positioning device to reduce occipital pressure injuries (PIs). A post-test design with a historical control group was used in a 54-bed intensive care unit between September 2017 and August 2018. Patients who were receiving either extracorporeal membrane oxygenation, were mechanically ventilated, or had raised intracranial pressure (≥20) were recruited. Read More

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http://dx.doi.org/10.1111/iwj.13051DOI Listing
December 2018

Management of non-missile penetrating spinal injury.

Neurosurg Rev 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

Review of the literature with case illustration. Non-missile penetrating spinal injury (NPSI) represents a small subset of spinal cord injuries at tertiary trauma centers and is comprised mostly of knife violence. Strict guidelines for the management of penetrating spinal cord injury remain elusive given the variability of mechanisms, rarity of clinical experience, and paucity of prospective studies. Read More

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http://dx.doi.org/10.1007/s10143-018-01057-1DOI Listing
December 2018

Forensic 3D documentation of skin injuries using photogrammetry: photographs vs video and manual vs automatic measurements.

Int J Legal Med 2018 Dec 17. Epub 2018 Dec 17.

Section of Forensic Pathology, Department of Forensic Medicine, University of Copenhagen, Frederik d. 5.´s Vej 11, 2100, Copenhagen, Denmark.

Accurate and precise documentation of lesions is an important aspect of the forensic pathologists' work. Photogrammetry provides a useful tool to take precise measurements from photographs. These photographs are normally acquired with single camera photographs, but the procedure is quite time-consuming. Read More

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http://dx.doi.org/10.1007/s00414-018-1982-6DOI Listing
December 2018

Mechanisms and Management of Chimeric Antigen Receptor T-Cell Therapy-Related Toxicities.

BioDrugs 2018 Dec 17. Epub 2018 Dec 17.

Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, 12902 Magnolia Drive, FOB-3, Tampa, FL, 33612, USA.

Chimeric antigen receptor T-cell (CAR-T) therapy has proven to be a very effective cancer immunotherapy. Axicabtagene ciloleucel and tisagenlecleucel are the first-in-class anti-CD19 CAR-T currently available for relapsed/refractory adult large B-cell lymphoma. Tisagenlecleucel is also available for pediatric and young adult (up to age 25 years) patients with relapsed/refractory B-acute lymphoblastic leukemia. Read More

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http://dx.doi.org/10.1007/s40259-018-0324-zDOI Listing
December 2018

Risk of extrapelvine vascular injuries in osteosynthesis with gliding hip screws.

Arch Orthop Trauma Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Traumatology and Sports Injuries, Paracelsus Medical University Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Austria.

Background: Dynamic hip screw (DHS) osteosynthesis represents one of the most frequently performed fixation methods in orthopedic practice. The purpose of this study was to determine the potential risk of vascular damage by DHS side-plate screws (PS) and plunging instruments for individual femoral vessels and screw positions.

Methods: In ten hemipelvic/leg specimens mounted with a large femur distractor, a DHS system with a four-hole side-plate was inserted. Read More

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http://link.springer.com/10.1007/s00402-018-3077-8
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http://dx.doi.org/10.1007/s00402-018-3077-8DOI Listing
December 2018
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NMJ maintenance and repair in aging.

Curr Opin Physiol 2018 Aug 11;4:57-64. Epub 2018 Jun 11.

Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA.

As the final output of the somatic nervous system, the neuromuscular junction (NMJ) is essential for all voluntary movements. The NMJ is also necessary for connected cells to function and survive. Because of this central role, much effort has been devoted to understanding the effects of aging, diseases, and injuries on the NMJ. Read More

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http://dx.doi.org/10.1016/j.cophys.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294463PMC

Timed Up and Go test is predictive of Patient-Reported Outcomes Measurement Information System physical function in patients awaiting total knee arthroplasty.

Arthroplast Today 2018 Dec 1;4(4):505-509. Epub 2018 Sep 1.

Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: The Patient Reported Outcomes Measurement Information System (PROMIS) Computerized Adaptive Test (CAT) physical function rapidly assesses self-reported function capability. The Timed Up and Go (TUG) test is often used in clinical practice, but administration may be impeded by space and patient limitations. PROMIS CAT can potentially address these limitations, but we lack evidence if TUG and health indicators are predictors of PROMIS CAT. Read More

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http://dx.doi.org/10.1016/j.artd.2018.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287225PMC
December 2018

Relationship Between Time to ACL Reconstruction and Presence of Adverse Changes in the Knee at the Time of Reconstruction.

Orthop J Sports Med 2018 Dec 11;6(12):2325967118813917. Epub 2018 Dec 11.

Glen Sather Sports Medicine Clinic, University of Alberta, Edmonton, Alberta, Canada.

Background: Treatment of patients with anterior cruciate ligament (ACL) injuries is often complicated by secondary damage to the meniscus and cartilage.

Purpose: To assess the association between time from ACL tear to ACL reconstruction (ACLR) and the presence of intra-articular injuries at the time of ACLR, including meniscal tears, irreparable meniscal tears, chondral damage, and knee compartment degenerative changes.

Study Design: Cross-sectional study; Level of evidence, 3. Read More

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http://dx.doi.org/10.1177/2325967118813917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293370PMC
December 2018

Athletes With Musculoskeletal Injuries Identified at the NFL Scouting Combine and Prediction of Outcomes in the NFL: A Systematic Review.

Orthop J Sports Med 2018 Dec 12;6(12):2325967118813083. Epub 2018 Dec 12.

Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, New York, USA.

Background: Prior to the annual National Football League (NFL) Draft, the top college football prospects are evaluated by medical personnel from each team at the NFL Scouting Combine. On the basis of these evaluations, each athlete is assigned an orthopaedic grade from the medical staff of each club, which aims to predict the impact of an athlete's injury history on his ability to participate in the NFL.

Purpose: (1) To identify clinical predictors of signs, symptoms, and subsequent professional participation associated with football-related injuries identified at the NFL Combine and (2) to assess the methodological quality of the evidence currently published. Read More

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http://dx.doi.org/10.1177/2325967118813083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293380PMC
December 2018

Injury Risk and Injury Burden Are Related to Age Group and Peak Height Velocity Among Talented Male Youth Soccer Players.

Orthop J Sports Med 2018 Dec 11;6(12):2325967118811042. Epub 2018 Dec 11.

Physiotherapy Utrecht Oost, Utrecht, the Netherlands.

Background: The relationship between injury risk (IR) in age groups and periods around peak height velocity (PHV) remains unclear. PHV is defined as the moment of the largest increase in body height.

Purpose: To investigate injury risk and injury burden as functions of growth velocity (periods around PHV) and chronological age groupings (under 12 years [U12] to U19) in talented youth male soccer players. Read More

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http://dx.doi.org/10.1177/2325967118811042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293374PMC
December 2018

Effect of Playing and Training at Altitude on Concussion Incidence in Professional Football.

Orthop J Sports Med 2018 Dec 7;6(12):2325967118794928. Epub 2018 Dec 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Despite the increased attention to sports-related concussion, the literature lacks information about the environmental factors that contribute to concussion incidence. Previous investigators have noted a decreased rate of concussion in football games played at higher altitude.

Purpose/hypothesis: The purpose of this study was to investigate whether the protective effects of altitude on concussion rate, as described by previous investigators, were due to acute effects of altitude exposure or chronic adaptations to training at altitude. Read More

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http://dx.doi.org/10.1177/2325967118794928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293377PMC
December 2018

Degloving Injuries of Upper Extremity: A Strategy with Full Thickness Skin Mesh.

World J Plast Surg 2018 Sep;7(3):372-376

Clinic for Plastic and Aesthetic Surgery, Hand Surgery, Helios Clinics Gifhorn, University of Magdeburg, Germany.

Degloving injuries of the upper extremity during work are rare nowadays, because of effective worker protection devices. However, these devastating injuries still occur today during motor vehicle car accidents and surgeons have to be aware of the possibilities of wound coverage for these large, contaminated wounds. We present two cases of degloving injuries of the hand and entire forearm using degloved skin as meshed full thickness skin graft to cover the entire wound. Read More

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http://dx.doi.org/10.29252/wjps.7.3.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290308PMC
September 2018

Effect of Resin Oil on Anti-Oxidant, Hydroxyprolin and VEGF Changes in Experimentally-Induced Skin Burn in Rat.

World J Plast Surg 2018 Sep;7(3):357-363

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Background: Severe burn damage and its consequences are life threatening which can complicate patients' health. Medicinal and traditional plants are considered as safe, natural and inexpensive source of treatment for wide variety of diseases. This study assessed beneficial effect of oil on rats burn wound healing and its potential effects on malondialdehyde (MDA), vasculoendothelial growth factor (VEGF), hydroxyprolin and antioxidant status in wound area. Read More

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http://dx.doi.org/10.29252/wjps.7.3.357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290311PMC
September 2018

Age and Number of Surgeries Increase Risk for Complications in Polytrauma Patients with Operative Maxillofacial Fractures.

World J Plast Surg 2018 Sep;7(3):307-313

Department of Plastic Surgery, University of California, Irvine; Orange, CA, USA.

Background: Poly-trauma patients often sustain complex head/neck injuries requiring prolonged hospitalizations and multiple operations. Few studies have evaluated the associated injury patterns and risk factors for poor clinical outcomes.

Methods: Consecutive poly-trauma patients with operative maxillofacial fractures treated at a level 1 trauma medical center between 1995 and 2013 were evaluated. Read More

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http://dx.doi.org/10.29252/wjps.7.3.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290318PMC
September 2018

Interruptions, Unreasonable Tasks, and Quality-Threatening Time Pressure in Home Care: Linked to Attention Deficits and Slips, Trips, and Falls.

Saf Health Work 2018 Dec 11;9(4):434-440. Epub 2018 Feb 11.

University of Bern, Switzerland.

Background: In industrial countries, home care of community dwelling elderly people is rapidly growing. Frequent injuries in home caregivers result from slips, trips, and falls (STFs). The current study tests attentional cognitive failure to mediate the association between work stressors and STFs. Read More

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http://dx.doi.org/10.1016/j.shaw.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284161PMC
December 2018

The Relationship Between Frequency of Injuries and Workplace Environment in Korea: Focus on Shift Work and Workplace Environmental Factors.

Authors:
Jongwoo Kim

Saf Health Work 2018 Dec 21;9(4):421-426. Epub 2018 Feb 21.

Department of Sociology, Yonsei University, Seoul, Republic of Korea.

Background: The purpose of this study was to investigate the effect of shift work on occupational safety in various industrial sectors. The study analyzes the effects of shift work on the health of workers by considering factors such as the workplace environment and welfare.

Methods: Focusing on the 4 Korean Working Conditions Survey, this study used an ordinary least-square multiple regression analysis. Read More

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http://dx.doi.org/10.1016/j.shaw.2018.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284151PMC
December 2018

Nursing Home Employee and Resident Satisfaction and Resident Care Outcomes.

Saf Health Work 2018 Dec 8;9(4):408-415. Epub 2018 Jan 8.

Department of Work Environment & Center for the Promotion of Health in the New England Workplace (CPHNEW), University of Massachusetts Lowell, Lowell, MA, USA.

Background: Nursing home resident care is an ongoing topic of public discussion, and there is great interest in improving the quality of resident care. This study investigated the association between nursing home employees' job satisfaction and residents' satisfaction with care and medical outcomes.

Methods: Employee and resident satisfaction were measured by questionnaire in 175 skilled nursing facilities in the eastern United States from 2005 to 2009. Read More

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http://dx.doi.org/10.1016/j.shaw.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284169PMC
December 2018

S100B Serum Level as a Mortality Predictor for Traumatic Brain Injury: A Meta-Analysis.

Open Access Maced J Med Sci 2018 Nov 15;6(11):2239-2244. Epub 2018 Nov 15.

Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia.

Background: The pathogenesis of inflammatory neuronal cell damage will continue after traumatic brain injury in which contributed to subsequent mortality. Serum S100B levels were shown to be an early predictor of mortality due to traumatic brain injury.

Aim: This Meta-Analysis will analyse the mean and diagnostic strength of serum S100B levels between survived and died subjects with head injuries based on the various follow-up times of nine studies. Read More

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http://dx.doi.org/10.3889/oamjms.2018.432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290435PMC
November 2018

The Relationship between Nurse's Job Stress and Patient Safety.

Open Access Maced J Med Sci 2018 Nov 23;6(11):2228-2232. Epub 2018 Nov 23.

Department of Health in Disasters and Emergencies, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Patient safety is a key element of the quality of health services. Nurses are the largest group that care for patients, observing safe in nursing care would reduce injuries, disability, morbidity and mortality. However, high stress can lead to a decline in the quality of nursing care. Read More

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http://dx.doi.org/10.3889/oamjms.2018.351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290432PMC
November 2018

The Relationship between Clinical Findings of Shoulder Joint with Bone Damage of Shoulder Joint in Patients with Isolated Shoulder Blunt Trauma.

Open Access Maced J Med Sci 2018 Nov 20;6(11):2101-2106. Epub 2018 Nov 20.

Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Due to the prevalence of shoulder injuries among athletes and other people and the prevalence of radiography for these injuries, there are still no valid criteria for indication of doing shoulder radiography.

Aim: This study aimed to examine the relationship between some signs and clinical examinations of the shoulder with shoulder bone injuries and the need for radiography.

Methods: This is a cross-sectional study. Read More

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http://dx.doi.org/10.3889/oamjms.2018.478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290453PMC
November 2018

The Effects of Filgrastim on Complications of Patients with Cerebral Hemorrhage Due To Head Trauma.

Open Access Maced J Med Sci 2018 Nov 8;6(11):2030-2034. Epub 2018 Nov 8.

Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: Filgrastim, a neopogen brand, is a blood-forming agent and a natural protein in the body that plays a role in stimulating the growth of white blood cells and protecting them against infectious agents. To the best of knowledge, human and animal specimens have shown the effect of Filgrastim on treating brain injuries regarding bone marrow transfusion into the blood, neuroprotection, stimulation of neurons for forming new neural networks and reducing the risk of bacterial infections.

Aim: This study aimed to investigate the effect of Filgrastim on the prognosis of a cerebral haemorrhage in patients with traumatic brain injury. Read More

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http://dx.doi.org/10.3889/oamjms.2018.412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290401PMC
November 2018

Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats.

J Otol 2018 Jun 9;13(2):44-53. Epub 2018 Mar 9.

Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.

Blast overpressure has become an increasing cause of brain injuries in both military and civilian populations. Though blast's direct effects on the cochlea and vestibular organs are active areas of study, little attention has been given to the ear's contribution to the overall spectrum of blast injury. Acute autonomic responses to blast exposure, including bradycardia and hypotension, can cause hypoxia and contribute to blast-induced neurotrauma. Read More

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http://dx.doi.org/10.1016/j.joto.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291641PMC

Hidden cochlear impairments.

Authors:
Guang-Di Chen

J Otol 2018 Jun 18;13(2):37-43. Epub 2018 May 18.

Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.

Pure tone audiometry is a routine clinical examination used to identify hearing loss. A normal pure tone audiogram is usually taken as evidence of normal hearing. Auditory deficits detected in subjects with normal audiograms, such as poor sound discrimination and auditory perceptual disorders, are generally attributed to central problems. Read More

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http://dx.doi.org/10.1016/j.joto.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291639PMC

Concussion Subtype Identification With the Rivermead Post-concussion Symptoms Questionnaire.

Front Neurol 2018 3;9:1034. Epub 2018 Dec 3.

Brain Trauma Foundation, New York, NY, United States.

Classifying concussion in key subtypes according to presenting symptomatology at an early post-injury stage is an emerging approach that may allow prediction of clinical trajectories and delivery of targeted treatments. The Rivermead Post-concussion Symptoms Questionnaire (RPQ) is a simple, freely available, and widely used tool for assessment of the presence and severity of various post-concussion symptoms. We aimed to probe the prevalence among athletes of symptom classes associated with identified concussion phenotypes using the RPQ at baseline and acutely after a concussion. Read More

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http://dx.doi.org/10.3389/fneur.2018.01034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287109PMC
December 2018

Frequency and Stratification of Epileptogenic Lesions in Elderly With New Onset Seizures.

Front Neurol 2018 30;9:995. Epub 2018 Nov 30.

American University of Beirut Medical Center, Beirut, Lebanon.

To evaluate prospectively the frequency of epileptogenic lesions in a consecutive cohort of elderly patients presenting with new onset unprovoked seizures, and who underwent a complete evaluation including dedicated epilepsy protocol MRI. We included all consecutive patients 60 years or older who participated in a prospective study on new onset epilepsy. The work-up included the acquisition of a dedicated epilepsy protocol MRI and a 3 h video/EEG recording. Read More

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http://dx.doi.org/10.3389/fneur.2018.00995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284348PMC
November 2018

Lightning injuries in Northern Ireland.

Ulster Med J 2018 Oct 1;87(3):168-172. Epub 2018 Oct 1.

Burns Unit, Royal Victoria Hospital, Belfast.

Introduction: Lightning injuries are uncommon in Northern Ireland (NI) with scarce reports detailing incidence and local experience. We present a case study of 3 patients involved in a single lightning strike with a review of the incidence of similar injuries in the province.

Methods: Data from TORRO's National Lightning Incidents Database between 1987 and 2016 (30 years) were searched to identify victims of lightning injuries in NI. Read More

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October 2018

Time and Other Considerations in Mediation Design.

Educ Psychol Meas 2018 Dec 18;78(6):952-972. Epub 2017 Dec 18.

University of Notre Dame, Notre Dame, IN, USA.

This article serves as a practical guide to mediation design and analysis by evaluating the ability of mediation models to detect a significant mediation effect using limited data. The cross-sectional mediation model, which has been shown to be biased when the mediation is happening over time, is compared with longitudinal mediation models: sequential, dynamic, and cross-lagged panel. These longitudinal mediation models take time into account but bring many problems of their own, such as choosing measurement intervals and number of measurement occasions. Read More

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http://dx.doi.org/10.1177/0013164417743003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293418PMC
December 2018
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