689,269 results match your criteria In Vivo International Journal of Experimental and Clinical Pathophysiology and Drug Research[Journal]


A simplified fabrication technique for cellularized high-collagen dermal equivalents.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Product Development Group Zurich, Eidgenossische Technische Hochschule Zurich Departement Maschinenbau und Verfahrenstechnik, Zurich, ZH, SWITZERLAND.

Human autologous bioengineered skin has been successfully developed and used to treat skin injuries in a growing number of cases. In current clinical studies, the biomaterial used is fabricated via plastic compression of collagen hydrogel to increase the density and stability of the tissue. To further facilitate clinical adoption of bioengineered skin, the fabrication technique needs to be improved in terms of standardization and automation. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c5DOI Listing
February 2019

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Clinical Pharmacology.

The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients. Testing methods for variants in ABCB1, CBR3, COMT, CYP3A7, C8ORF34, FCGR2A, FCGR3A, HAS3, NT5C2, NUDT15, SBF2, SEMA3C, SLC16A5, SLC28A3, SOD2, TLR4, and TPMT were validated in a CLIA-accredited laboratory. As no known reference materials were available, DNA samples that were from Coriell Cell Repositories (Camden, NJ) were used for the analytical validation studies. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.009DOI Listing
February 2019

Autologous Transplantation for Male Germ Cell Tumors: Improved Outcomes over 3 decades.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Medical College of Wisconsin, Milwaukee, WI.

Purpose: The curative potential of autologous hematopoietic cell transplantation (autoHCT) for male germ cell tumors (GCT) is well established. Optimal timing and number (single, ST vs. tandem, TT vs. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.015DOI Listing
February 2019

Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro.

J Ethnopharmacol 2019 Feb 19. Epub 2019 Feb 19.

Centre for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Straße 115 B, 79106 Freiburg, Germany. Electronic address:

Ethnopharmacological Relevance: The improvement of wound healing has always been an important issue for both ethnopharmacological and modern medical research. In this study, we used state-of-the-art methods to investigate extracts of plants used traditionally in Nepal for more than 1,000 years to treat inflammatory skin injuries.

Aim Of The Study: We focused on the potential of the plant extracts to ameliorate wound healing and to influence immune modulatory properties. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.034DOI Listing
February 2019

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Toxicol Appl Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ, USA. Electronic address:

Introduction: Nonalcoholic steatohepatitis (NASH) afflicts 20-36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages express folate receptor beta (FR-β) which may be an indicator of progression from steatosis to NASH. Read More

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http://dx.doi.org/10.1016/j.taap.2019.02.009DOI Listing
February 2019

BioNetApp: An interactive visual data analysis platform for molecular expressions.

PLoS One 2019 22;14(2):e0211277. Epub 2019 Feb 22.

Department of Chemistry, University of Louisville, Louisville, KY, United States of America.

Motivation: Systems biology faces two key challenges when dealing with large amounts of disparate data produced by different experiments: the integration of results across different experiments, and the extraction of meaningful information from the data produced by these experiments. An ongoing challenge is to provide better tools that can mine data patterns that could not have been discovered through simple visualization. Such mining capabilities also need to be coupled with intuitive visualization to portray those findings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211277PLOS
February 2019

Blunt cardiac injury: emergency department diagnosis and management.

Emerg Med Pract 2019 Mar 1;21(3):1-20. Epub 2019 Mar 1.

Associate Professor, Residency Program Director, SUNY Upstate Medical University, Syracuse, NY.

Blunt cardiac injury describes a range of cardiac injury patterns resulting from blunt force trauma to the chest. Due to the multitude of potential anatomical injuries blunt force trauma can cause, the clinical manifestations may range from simple ectopic beats to fulminant cardiac failure and death. Because there is no definitive, gold-standard diagnostic test for cardiac injury, the emergency clinician must utilize an enhanced index of suspicion in the clinical setting combined with an evidence-based diagnostic testing approach in order to arrive at the diagnosis. Read More

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System Setup to Deliver Air Impact Forces to a Sheep Limb: Preparation for Model Development of Blast-Related Heterotopic Ossification.

JMIR Res Protoc 2019 Feb 22;8(2):e12107. Epub 2019 Feb 22.

Department of Orthopaedics, University of Utah, Salt Lake City, UT, United States.

Background: Heterotopic ossification (HO) is a significant complication for wounded warriors with traumatic limb loss. Although this pathologic condition negatively impacts the general population, ectopic bone has been observed with higher frequency for service members injured in Iraq and Afghanistan due to blast injuries. Several factors, including a traumatic insult, bioburden, tourniquet and wound vacuum usage, and bone fractures or fragments have been associated with increased HO for service members. Read More

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http://dx.doi.org/10.2196/12107DOI Listing
February 2019

Can AI Help Reduce Disparities in General Medical and Mental Health Care?

AMA J Ethics 2019 Feb 1;21(2):E167-179. Epub 2019 Feb 1.

An assistant professor of computer science and medicine at the University of Toronto and a faculty member at the Vector Institute, both in in Ontario, Canada; and previously served as a visiting researcher at Alphabet Inc. within its life sciences research organization, Verily, and as a postdoctoral fellow at the Massachusetts Institute of Technology.

Background: As machine learning becomes increasingly common in health care applications, concerns have been raised about bias in these systems' data, algorithms, and recommendations. Simply put, as health care improves for some, it might not improve for all.

Methods: Two case studies are examined using a machine learning algorithm on unstructured clinical and psychiatric notes to predict intensive care unit (ICU) mortality and 30-day psychiatric readmission with respect to race, gender, and insurance payer type as a proxy for socioeconomic status. Read More

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http://dx.doi.org/10.1001/amajethics.2019.167DOI Listing
February 2019

LINGO-1 shRNA loaded by Pluronic F-127 promotes functional recovery after ventral root avulsion.

Tissue Eng Part A 2019 Feb 22. Epub 2019 Feb 22.

Dongguan, China ;

Spinal root avulsion typically leads to massive motoneuron death and severe functional deficits of the target muscles. Multiple pathological factors such as severe neuron loss, induction of inhibitory molecules, and insufficient regeneration are responsible for the poor functional recovery. LINGO-1, a CNS-specific transmembrane protein that is selectively expressed on neurons and oligodendrocytes, serves as a potent negative mediator of axonal regeneration and myelination in CNS injuries and diseases. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0282DOI Listing
February 2019

Epidemiology of Hyphema-Related Emergency Department Visits in The United States Between 2006 and 2015.

Ophthalmic Epidemiol 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Wilmer Eye Institute , Johns Hopkins Hospital , Baltimore , USA.

Purpose: To describe epidemiological trends, risk factors, and hospital-associated charges for patients presenting with hyphema to emergency departments (EDs) throughout the United States (U.S.). Read More

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http://dx.doi.org/10.1080/09286586.2019.1579917DOI Listing
February 2019

Stable isotopes of H, C and N in mice bone collagen as a reflection of isotopically controlled food and water intake.

Isotopes Environ Health Stud 2019 Feb 22:1-21. Epub 2019 Feb 22.

c School of Optometry , Indiana University , Bloomington , IN , USA.

H/H ratios in animal biomass reflect isotopic input from food and water. A 10-week controlled laboratory study raised 48 mice divided in two generations (8 mothers Mus musculus and their offspring). The mice were divided into four groups based on the combination of H, C, N-enriched and non-enriched food and water. Read More

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http://dx.doi.org/10.1080/10256016.2019.1580279DOI Listing
February 2019

[Update about management of knee tendinopathies].

Rev Med Liege 2019 Feb;74(2):63-67

Service de Médecine physique, CHU Liège, Belgique.

Knee tendinopathies account for a large number of sports dropping, especially in sports requesting jumps and running. There is actually no consensus about the management of those injuries. Nevertheless, new therapies may offer possibilities to the non-responding ones. Read More

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February 2019

Wuzhi capsule regulates chloroacetaldehyde pharmacokinetics behavior and alleviates high-dose cyclophosphamide-induced nephrotoxicity and neurotoxicity in rats.

Basic Clin Pharmacol Toxicol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, P. R. China.

High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Capsule (WZC) on the pharmacokinetics of CTX and its metabolites in rats, and the attenuation of CAA induced kidney and brain injuries, which was produced at equimolar with 2-dechloroethylcyclophosphamide. Read More

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http://dx.doi.org/10.1111/bcpt.13211DOI Listing
February 2019

Patient-reported scar quality of adults after burn injuries: a five-year multicenter follow-up study.

Wound Repair Regen 2019 Jan 11. Epub 2019 Jan 11.

Association of Dutch Burn Centres, Maasstad Hospital, Rotterdam, the Netherlands.

Scar formation is an important adverse consequence of burns. How patients appraise their scar quality is often studied shortly after sustaining the injury, but information in the long-term is scarce. Our aim was therefore to evaluate long-term patient-reported quality of burn scars. Read More

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http://dx.doi.org/10.1111/wrr.12709DOI Listing
January 2019

Delivery mode, levator avulsion and obstetric anal sphincter injury: A cross-sectional study 20 years after childbirth.

Aust N Z J Obstet Gynaecol 2019 Feb 21. Epub 2019 Feb 21.

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Background: Levator ani muscle (LAM) and anal sphincter injuries are common after vaginal birth and are associated with pelvic organ prolapse and anal incontinence.

Aims: Our objective was to investigate long-term association between delivery mode, LAM avulsion and obstetric anal sphincter injuries (OASIS) in women at least 20 years after their first birth.

Methods: All women recruited at 'index birth' of the Dunedin (New Zealand) arm of ProLong (PROlapse and incontinence LONG-term research) Study, were invited to have translabial and transperineal ultrasound assessment of LAM and anal sphincters. Read More

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http://dx.doi.org/10.1111/ajo.12948DOI Listing
February 2019

A Descriptive Analysis of Causalities Undergoing CASEVAC from the Point-of-Injury in the Department of Defense Trauma Registry.

Mil Med 2019 Feb 22. Epub 2019 Feb 22.

Brooke Army Medical Center, JBSA Fort Sam Houston, TX.

Introduction: The recent conflicts in Iraq and Afghanistan entail an asymmetric battlefield without clearly defined forward lines of troops as seen in previous wars. Accordingly, the United States military medical services have increasingly adopted casualty evacuation (CASEVAC) platforms. We describe CASEVAC events reported within the Department of Defense Trauma Registry (DODTR). Read More

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http://dx.doi.org/10.1093/milmed/usz015DOI Listing
February 2019

Centralized and distributed cognitive task processing in the human connectome.

Netw Neurosci 2019 1;3(2):455-474. Epub 2019 Feb 1.

School of Industrial Engineering, Purdue University, West-Lafayette, IN, USA.

A key question in modern neuroscience is how cognitive changes in a human brain can be quantified and captured by functional connectivity (FC). A systematic approach to measure pairwise functional distance at different brain states is lacking. This would provide a straightforward way to quantify differences in cognitive processing across tasks; also, it would help in relating these differences in task-based FCs to the underlying structural network. Read More

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http://dx.doi.org/10.1162/netn_a_00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370483PMC
February 2019

Computation is concentrated in rich clubs of local cortical networks.

Netw Neurosci 2019 1;3(2):384-404. Epub 2019 Feb 1.

Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.

To understand how neural circuits process information, it is essential to identify the relationship between computation and circuit organization. Rich clubs, highly interconnected sets of neurons, are known to propagate a disproportionate amount of information within cortical circuits. Here, we test the hypothesis that rich clubs also perform a disproportionate amount of computation. Read More

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http://dx.doi.org/10.1162/netn_a_00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370472PMC
February 2019

High-accuracy individual identification using a "thin slice" of the functional connectome.

Netw Neurosci 2019 1;3(2):363-383. Epub 2019 Feb 1.

Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.

Connectome fingerprinting-a method that uses many thousands of functional connections in aggregate to identify individuals-holds promise for individualized neuroimaging. A better characterization of the features underlying successful fingerprinting performance-how many and which functional connections are necessary and/or sufficient for high accuracy-will further inform our understanding of uniqueness in brain functioning. Thus, here we examine the limits of high-accuracy individual identification from functional connectomes. Read More

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http://dx.doi.org/10.1162/netn_a_00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370471PMC
February 2019

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents.

Commun Biol 2019 20;2:71. Epub 2019 Feb 20.

3Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.

The cornea plays an important role in transmitting light and providing protection to the eye, but is susceptible to injury and infection. Standard treatments for corneal wounds include topical lubricants, antibiotics, bandage contact lens, and surgery. However, these measures are often ineffective. Read More

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http://dx.doi.org/10.1038/s42003-019-0316-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382791PMC
February 2019

Effect of prehospital tourniquets on resuscitation in extremity arterial trauma.

Trauma Surg Acute Care Open 2019 24;4(1):e000267. Epub 2019 Jan 24.

Department of Surgery, UNLV School of Medicine, Las Vegas, Nevada, USA.

Background: Timely tourniquet placement may limit ongoing hemorrhage and reduce the need for blood products. This study evaluates if prehospital tourniquet application altered the initial transfusion needs in arterial injuries when compared with a non-tourniquet control group.

Methods: Extremity arterial injuries were queried from our level I trauma center registry from 2013 to 2017. Read More

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http://dx.doi.org/10.1136/tsaco-2018-000267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350723PMC
January 2019

Experience of thyroid surgery at tertiary referral centers in Jazan Hospitals, Saudi Arabia.

Interv Med Appl Sci 2018 Dec;10(4):198-201

Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Prince Mohammed bin Nasser Hospital, Jazan, Saudi Arabia.

Background: Benign multinodular goiter (BMNG) is a common disease of the thyroid gland with palpable thyroid nodules that may be detected in 0.8%-1.5% of men and 5. Read More

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http://dx.doi.org/10.1556/1646.10.2018.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376351PMC
December 2018

Managing the health of the eSport athlete: an integrated health management model.

BMJ Open Sport Exerc Med 2019 10;5(1):e000467. Epub 2019 Jan 10.

Center for Sports Medicine NYIT-COM, New York City, New York, USA.

Objectives: eSport is a form of electronic gaming, also known as professional or competitive video gaming, and is growing at a rapid pace worldwide. Over 50 US colleges have established varsity gaming teams over the past three years; some colleges offer eSport scholarships as they do for traditional sports. There is little objective research on the health habits of these players who are often placed under the direction of the athletics department on college campuses, and there is currently no health management model on how to treat these new athletes. Read More

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http://dx.doi.org/10.1136/bmjsem-2018-000467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350739PMC
January 2019

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future.

Front Pharmacol 2019 7;10:95. Epub 2019 Feb 7.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.

Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies. Therefore, understanding the mediators involved in their pathophysiology is necessary for the development of therapeutic strategies. Read More

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http://dx.doi.org/10.3389/fphar.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374558PMC
February 2019

Tooth 'aches': Injuries related to toothbrush use.

Paediatr Child Health 2019 Feb 31;24(1):e40-e44. Epub 2018 May 31.

Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, Ontario.

Objectives: A toothbrush is a medical device that is widely used for oral hygiene practices at almost all ages. Descriptive studies of toothbrush-related injuries (TRI) are fairly limited, with existing studies mainly focusing on case reports. The present study sought to describe TRIs in Canada, including the contexts within which they occur. Read More

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http://dx.doi.org/10.1093/pch/pxy073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376299PMC
February 2019

The ups and downs of trampolines: Injuries associated with backyard trampolines and trampoline parks.

Paediatr Child Health 2019 Feb 17;24(1):e19-e25. Epub 2018 May 17.

Surveillance and Epidemiology Division, Public Health Agency of Canada, Ottawa, Ontario.

Objective: To compare characteristics associated with backyard trampoline injuries (BTI) and trampoline park injuries (TPI) using records from the electronic Canadian Hospitals Injury Reporting and Prevention Program (eCHIRPP).

Methods: eCHIRPP records for trampoline injuries (2012 to 2016) were extracted using variable codes and narratives, and injuries were examined among individuals 17 years and younger. Descriptive estimates for BTI and TPI, as well as age and sex adjusted odds ratios (OR) for the mechanism, source, body part and type of injury associated with TPIs relative to BTIs, are presented. Read More

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http://dx.doi.org/10.1093/pch/pxy066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376289PMC
February 2019

All-terrain vehicle serious injuries and death in children and youth: A national survey of Canadian paediatricians.

Paediatr Child Health 2019 Feb 18;24(1):e13-e18. Epub 2018 Jun 18.

Department of Paediatrics, University of Toronto, Toronto, Ontario.

Background: All-Terrain Vehicles (ATVs) are a leading cause of serious injury in children and youth. Certain Canadian regions have implemented legislation to promote safety, including age restrictions, mandatory training and helmet use. Jurisdictions with more stringent ATV safety legislation have been shown to have reduced injury rates in the short term. Read More

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http://dx.doi.org/10.1093/pch/pxy059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376310PMC
February 2019

Demonstrating the financial impact of mining injuries with the "Safety Pays in Mining" web application.

Authors:
J R Heberger

Min Eng 2018 Dec;70(12):37-43

epidemiologist at CDC NIOSH, Pittsbrgh, PA, USA.

The "Safety Pays in Mining" web application, developed by the U.S. National Institute for Occupational Safety and Health Mining Program, helps mines determine the potential costs associated with mining injuries. Read More

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http://dx.doi.org/10.19150/me.8643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379894PMC
December 2018

Publisher Correction: Human cognition involves the dynamic integration of neural activity and neuromodulatory systems.

Nat Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Department of Psychology, Stanford University, Stanford, CA, USA.

In the version of this article initially published, Kaylena A. Ehgoetz Martens' name was misspelled as Kayla. The error has been corrected in the HTML and PDF versions of the article. Read More

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http://dx.doi.org/10.1038/s41593-019-0347-xDOI Listing
February 2019
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Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.

Cell Death Dis 2019 Feb 21;10(3):180. Epub 2019 Feb 21.

Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.

Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential parameter of cancer metastasis. However, the role of K channels in cancer metastasis has been poorly studied. Read More

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http://dx.doi.org/10.1038/s41419-019-1429-0DOI Listing
February 2019

The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Background: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever burden from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, and the approach taken to produce them.

Methods: For this systematic analysis we broke down the relative contributions of typhoid and paratyphoid fevers by country, year, and age, and analysed trends in incidence and mortality. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30685-6DOI Listing
February 2019

Calculation of flexor pollicis longus moment arm for wrist motion in a cadaver model validates the tenodesis effect for therapy.

J Hand Ther 2019 Feb 18. Epub 2019 Feb 18.

Tendon and Soft Tissue Biology Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address:

Introduction: Synergies of fingers and wrist motion have been incorporated into therapies for finger flexor tendon injuries to improve repair outcomes. Similar synergistic therapy strategies have not been well documented for the thumb.

Purpose Of The Study: The purpose of this study was to investigate the extent to which wrist motion enables a synergistic effect at the thumb in a cadaveric model by measuring flexor pollicis longus excursion and calculating the moment arm of this tendon at the wrist joint. Read More

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http://dx.doi.org/10.1016/j.jht.2019.01.005DOI Listing
February 2019

Identification of key events in baseball hitting using inertial measurement units.

J Biomech 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Miyazaki, Japan.

Quantification of baseball hitting mechanics under game conditions help players to become successful batters and prevent injuries. Inertial measurement units (IMUs) can measure motion without any spatial restriction and are thus becoming a popular tool to investigate sports biomechanics. Biomechanical analysis of hitting requires the accurate detection of key events including "foot-off" while leaning back (F), "foot-on" during forward swing (F), and ball impact. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2019.02.001DOI Listing
February 2019

Soft Tissue and Bony Injuries Attributed to the Practice of Yoga: A Biomechanical Analysis and Implications for Management.

Mayo Clin Proc 2019 Feb 6. Epub 2019 Feb 6.

Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.

Objective: To analyze injuries that were directly associated with yoga practice and identify specific poses that should be avoided in patients with osteopenia or osteoporosis.

Patients And Methods: We retrospectively reviewed the medical records of patients with injuries that were primarily caused by yoga. Patients were seen from January 1, 2006, through December 31, 2018. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.09.024DOI Listing
February 2019

Follow-up imaging of traumatic vertebral artery dissections is unnecessary in asymptomatic patients.

J Vasc Surg 2019 Feb 18. Epub 2019 Feb 18.

Division of Vascular Surgery, University of Minnesota Medical Center, Minneapolis, Minn. Electronic address:

Objective: Routine computed tomography (CT) imaging in trauma patients has led to increased recognition of blunt vertebral artery injuries (BVIs). We sought to determine the prevalence of strokes, injury progression, and need for intervention in patients with BVI.

Methods: Consecutive patients presenting with BVI during 2 years were identified from the institutional trauma registry. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.09.051DOI Listing
February 2019

dStruct: identifying differentially reactive regions from RNA structurome profiling data.

Genome Biol 2019 Feb 21;20(1):40. Epub 2019 Feb 21.

Department of Biomedical Engineering and Genome Center, University of California, Davis, One Shields Avenue, Davis, 95616, CA, USA.

RNA biology is revolutionized by recent developments of diverse high-throughput technologies for transcriptome-wide profiling of molecular RNA structures. RNA structurome profiling data can be used to identify differentially structured regions between groups of samples. Existing methods are limited in scope to specific technologies and/or do not account for biological variation. Read More

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http://dx.doi.org/10.1186/s13059-019-1641-3DOI Listing
February 2019

Targeting Water in Brain: Role of Aquaporin-4 in Ischemic Brain Edema.

Curr Drug Targets 2019 Feb 13. Epub 2019 Feb 13.

Neuroscience and Neuroengineering Research Center, Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200000. China.

Brain edema primarily occurs as a consequence of various cerebral injuries including ischemia-induced brain damage. Excessive accumulation of brain water content causes a gradual expansion of brain parenchyma, decreased blood flow and increased intracranial pressure and, ultimately, cerebral herniation and death. Current clinical treatments for ischemic edema are very limited, therefore, it is urgent to develop a novel treatment strategy. Read More

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http://dx.doi.org/10.2174/1389450120666190214115309DOI Listing
February 2019

Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism.

Free Radic Biol Med 2019 Feb 18. Epub 2019 Feb 18.

Indiana University School of Medicine - South Bend Center, South Bend, IN, 46617, USA.

Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities. ROS are chemically and functionally similar to reactive sulfide species (RSS) and both ROS and RSS have been shown to be metabolized by the antioxidant enzymes, superoxide dismutase and catalase. Here we use fluorophores to examine the effects of a variety of inhibitors of antioxidant pathways on metabolism of two important RSS, hydrogen sulfide (HS with AzMC) and polysulfides (HS, where n = 2-7, with SSP4) in HEK293 cells. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.011DOI Listing
February 2019

Coordinating what we've learned about memory consolidation: Revisiting a unified theory.

Neurosci Biobehav Rev 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas Health Science Center, Houston, TX, 77030, USA.

According to traditional systems consolidation theories neocortical long-term plasticity (i.e., cellular consolidation) lags behind, and is dependent upon, hippocampal long-term plasticity. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.02.010DOI Listing
February 2019

Doping of carbon nanodots for saving cells from silver nanotoxicity: A study on recovering osteogenic differentiation potential.

Toxicol In Vitro 2019 Feb 18. Epub 2019 Feb 18.

School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India. Electronic address:

Silver nanoparticles are explored for many advanced biological applications including the development of antimicrobial surfaces on implants, SERS imaging, nanotherapeutics, biosensing and much more. However, recent research findings suggest silver nanoparticles provide blockade of differentiation of mesenchymal stem cells (MSCs), especially into osteogenic developmental pathway via generation of reactive oxygen species. These studies suggest that the application of silver nanoparticles in medical implants should be prohibited. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.015DOI Listing
February 2019

Substance-P Prevents Cardiac Ischemia-Reperfusion Injury by Modulating Stem Cell Mobilization and Causing Early Suppression of Injury-Mediated Inflammation.

Cell Physiol Biochem 2019 18;52(1):40-56. Epub 2019 Feb 18.

Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Hoegi-Dong, Republic of Korea.

Background/aims: Therapies using stem/progenitor cells have been experimentally and clinically investigated to regenerate damaged hearts. Substance-P (SP) induces bone marrow (BM) stem cell mobilization and suppresses inflammation in ischemic injuries. This study investigated the role of SP in BM stem cell mobilization and immune responses for tissue repair after ischemic-reperfusion injury (IRI), in comparison with that of granulocyte colony-stimulating factor (GCSF). Read More

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http://dx.doi.org/10.33594/000000004DOI Listing
February 2019

[The Organization of Functioning of Traumatological Station of Municipal Clinical Hospital: the Structure of Resort of Patients on the Occasion of Traumas].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2019 Jan;27(1):54-58

The Federal State Budget Educational Institution of Higher Education "The Bashkir State Medical University", 450008, Ufa, Russia.

The analysis of the structure of treatment of patients with injuries in traumatological station of municipal clinical hospital established that the percentage of females was slightly higher than that one of males, 50.9% and 49.1% respectively. Read More

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http://dx.doi.org/10.32687/0869-866X-2019-27-1-54-58DOI Listing
January 2019

Ocular injury during spine surgery.

Can J Anaesth 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose: Ocular injury and vision loss are rare complications of surgery. Spine surgery has been identified as particularly high risk for postoperative vision loss; nevertheless, ocular injuries have not been comprehensively assessed in this patient population.

Methods: This historical cohort study assessed incidence, cause, and risk factors of perioperative ocular injury after spine surgery at a tertiary care medical centre from January 1, 2006 through January 31, 2018. Read More

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http://dx.doi.org/10.1007/s12630-019-01323-wDOI Listing
February 2019

Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.

J Autism Dev Disord 2019 Feb 21. Epub 2019 Feb 21.

Department of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, USA.

Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. Read More

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http://dx.doi.org/10.1007/s10803-019-03921-5DOI Listing
February 2019

Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells.

In Vitro Cell Dev Biol Anim 2019 Feb 21. Epub 2019 Feb 21.

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

The mechanism whereby 17β-estradiol (E2) mediates insulin gene transcription has not been fully elucidated. In this study, exposure of hamster insulinoma (HIT-T15) cells to 5 × 10 to 1 × 10 M E2 led to a concentration-dependent decrease of insulin mRNA levels. Transient expression of the estrogen receptor (ER) in HIT-T15 cells revealed that estrogen receptor α (ERα) repressed transcription of the rat insulin II promoter in both ligand-dependent and ligand-independent manners. Read More

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http://dx.doi.org/10.1007/s11626-019-00328-5DOI Listing
February 2019

Characterization of all-terrain vehicle-related chest injury patterns in children.

Emerg Radiol 2019 Feb 21. Epub 2019 Feb 21.

McGovern Medical School, Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, 6431 Fannin Street, 2.130B, Houston, TX, 77030, USA.

Purpose: To evaluate chest injury patterns in pediatric patients involved in all-terrain vehicle (ATV) accidents.

Methods: Retrospective review of patients 0-18 years old admitted to a level I trauma institute following an ATV-related incident from 2004 to 2013 was performed. Chest injury type, accident mechanism, driver/passenger status, and demographic and clinical data were compared between patients with and without chest injury. Read More

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http://dx.doi.org/10.1007/s10140-019-01679-yDOI Listing
February 2019

Trauma registry data as a tool for comparison of practice patterns and outcomes between low- and middle-income and high-income healthcare settings.

Pediatr Surg Int 2019 Feb 21. Epub 2019 Feb 21.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Purpose: There is a lack of data-driven, risk-adjusted mortality estimates for injured children outside of high-income countries (HIC). To inform injury prevention and quality improvement efforts, an upper middle-income country (UMIC) pediatric trauma registry was compared to that of a HIC.

Methods: Clinical data, injury details, and mortality of injured children (< 18 years) hospitalized in two centers (USA and South African (SA)) from 2013 to 2017 were abstracted. Read More

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http://dx.doi.org/10.1007/s00383-019-04453-wDOI Listing
February 2019

Dog-bite injuries in Korea and risk factors for significant dog-bite injuries: A 6-year cross-sectional study.

PLoS One 2019 21;14(2):e0210541. Epub 2019 Feb 21.

Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.

Introduction: An accurate understanding of the current status of dog-bite injuries in Korea is essential for establishing preventive strategies. There have been no national reports about dog-bite injuries in Korea. This study investigated dog-bite injuries in Korea that were registered in the nationwide injury surveillance database and analysed the risk factors for significant dog-bite injury. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210541PLOS
February 2019
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