694,322 results match your criteria In Vivo International Journal of Experimental and Clinical Pathophysiology and Drug Research[Journal]


Corneal Endothelial Decompensation after Ocular Chemical Burn: Description of a New Finding.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):371-376. Epub 2019 Apr 18.

Augenklinik, Universitatsspital Basel, Basel, Switzerland.

Background: Ocular chemical burn is an ophthalmological emergency. Therefore, chemical injuries should be promptly addressed in order to initiate the appropriate treatment as soon as possible and optimize the visual prognosis. We present a retrospective study of ten cases with ocular chemical burn including one with superglue and one with a liquid plaster material injury and describe their clinical course. Read More

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http://dx.doi.org/10.1055/a-0857-6538DOI Listing

'When the dog bites': What can we learn about health geography from newspaper coverage in a 'model city' for dog-bite prevention?

Health Place 2019 Apr 15;57:70-73. Epub 2019 Apr 15.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Faculty of Social Work, University of Calgary, Canada.

Despite calls for the adoption of 'One-Health' approaches, dog-bite injuries remain neglected in healthcare and public health, and our study may help to understand why. Media coverage can influence policy directions, including policies that address dogs. We collected articles (n = 65) published in two local newspapers, 2012-2017, then carried out an ethnographically-informed discourse analysis of the dog-bite reports. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.03.001DOI Listing

Tibial tubercle avulsion fractures in school sports injury: A case report.

Int J Surg Case Rep 2019 Mar 28;58:30-32. Epub 2019 Mar 28.

Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat 10000, Morocco.

Introduction: Most injuries in adolescent occur during school sports like volleyball, football or basketball. Tibial tubercle avulsion fractures (TTAF) are an unusual condition, resulting from a forced extension of the knee opposed to fixed leg.

Presentation Of The Case: A 16 years old male was hurt during school basketball, X-rays displayed avulsion fracture of tibial tuberosity of left knee, the treatment was operative using two cancellous screws, results were good including complete knee mobility and early coming back to school sport at 6 months. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193013
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http://dx.doi.org/10.1016/j.ijscr.2019.03.017DOI Listing
March 2019
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The use of Episcissors-60 to reduce the rate of Obstetric Anal Sphincter Injuries: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 6;237:23-27. Epub 2019 Apr 6.

University Hospital Coventry, Clifford Bridge Road, Coventry, UK.

Objectives: The aim of this systematic review is to evaluate the effect of Episcissors-60, which were designed to improve the accuracy of episiotomies, on the rate of Obstetric Anal Sphincter Injuries.

Study Design: This review is registered with the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42018094935). A literature search of the PubMed, Embase and Cochrane databases was performed from inception to May 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.004DOI Listing

Naproxen impairs load-induced bone formation, reduces bone toughness, and diminishes woven bone formation following stress fracture in mice.

Bone 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

Debilitating stress fractures are surprisingly common in physically active individuals, including athletes, military recruits, and dancers. These individuals are overrepresented in the 30 million daily users of non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesized that regular use of NSAIDs would predispose habitually loaded bones to stress fracture and delay the repair of these injuries. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.009DOI Listing

Glyphaea brevis - In vitro antioxidant and in silico biological activity of major constituents and molecular docking analyses.

Toxicol In Vitro 2019 Apr 15. Epub 2019 Apr 15.

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, PMB 704, The Federal University of Technology, Akure, Nigeria.

Previous studies have revealed that leaf extracts of Glyphaea brevis possess antioxidant activity but the bioactivity and mechanisms of action of its major constituents remain unknown. This study evaluated in vitro antioxidant and free radical scavenging activities of Glyphaea brevis twigs and leaves, and probable toxicity profile, pharmacological activities and mechanisms of action of major phytoconstituents in silico. Phytochemical screening detected saponins, tannins, steroids, anthraquinones, flavonoids, terpenoids and phenolics in the extracts. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.013DOI Listing

Nurse-performed focused ultrasound in the emergency department: A systematic review.

Australas Emerg Care 2018 Nov 15;21(4):121-130. Epub 2018 Oct 15.

Prince of Wales Hospital Emergency Department, Barker Street, Sydney, Australia.

Aim: The objective of this systematic review was to examine the characteristics and diagnostic accuracy of focused ultrasonography performed by emergency nurses.

Background: Focused ultrasonography is a limited, real-time, goal-directed examination performed to answer specific clinical questions. Its use within the ED setting has increased rapidly over the past two decades. Read More

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http://dx.doi.org/10.1016/j.auec.2018.09.003DOI Listing
November 2018

The impact of unintentional alcohol-related falls on emergency departments.

Australas Emerg Care 2019 Mar 24;22(1):22-27. Epub 2018 Nov 24.

School of Health, University of New England, Armidale, NSW 2351, Australia.

Background: Alcohol is the cause of many injury presentations to the emergency department. There has been little research on alcohol-related falls in the broader adult population, which represent a substantial proportion of the total alcohol-related injury presentations to emergency departments.

Methods: A population-based retrospective analysis of public hospital emergency department presentations for Victoria for 2003-2015 was undertaken. Read More

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http://dx.doi.org/10.1016/j.auec.2018.11.001DOI Listing

Outcomes of single versus double fascicular nerve transfers for restoration of elbow flexion in patients with brachial plexus injuries: a systematic review and meta-analysis.

Plast Reconstr Surg 2019 Apr 11. Epub 2019 Apr 11.

Background: Elbow flexion after upper brachial plexus injury may be restored by a nerve transfer from the ulnar nerve to the biceps motor branch with an optional nerve transfer from the median nerve to the brachialis motor branch (single and double fascicular nerve transfer). This meta-analysis assesses the effectiveness of both techniques and the added value of additional reinnervation of the brachialis muscle.

Methods: Comprehensive searches were performed identifying studies concerning restoration of elbow flexion through single and double fascicular nerve transfers. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005720DOI Listing

Trochanteric Fractures in Young Children.

Pediatr Emerg Care 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Trauma and Orthopaediatrics, University Hospital of Wales, Cardiff, United Kingdom.

Background: Isolated avulsion fractures of the greater and lesser trochanter are usually seen in adolescents prior to the fusion of the apophysis. Greater trochanter fractures in adults have a high incidence of intertrochanteric extension and lesser trochanter fractures are regarded as a pathognomonic sign of metastatic disease. These fractures are very rare among children. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001825DOI Listing

Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Activation of the complement system and complement deposition on red blood cells (RBCs) contribute to organ damage in trauma. We conducted a prospective study in subjects with traumatic injuries to determine the pattern of complement deposition on RBC and whether they are associated with clinical outcomes.

Method: A total of 124 trauma patients and 42 healthy controls were enrolled in this prospective study. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001348DOI Listing

Erratum to: What Factors Are Associated With Disability After Upper Extremity Injuries? A Systematic Review.

Clin Orthop Relat Res 2019 May;477(5):1256

P. Jayakumar, S. Lamb, S. Gwilym, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Medicine, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK C. L. Overbeek, Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands M. Williams, Department of Sport and Health Sciences, Oxford Brookes University, Oxford, UK C. J. Funes, Department of Psychiatry (Behavioral Medicine Service), Boston, MA, USA D. Ring, The University of Texas at Austin, Department of Surgery and Perioperative Care, Dell Medical School, Austin, TX, USA A.-M. Vranceanu, Massachusetts General Hospital and Harvard Medical School, Behavioral Medicine Program, Department of Psychiatry, Boston, MA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000730DOI Listing

What Is the Association Between Articular Cartilage Damage and Subsequent THA 20 Years After Hip Arthroscopy for Labral Tears?

Clin Orthop Relat Res 2019 May;477(5):1211-1220

M. K. Dwyer, C. Tumpowsky, J. Lee, J. C. McCarthy, Kaplan Joint Center, Newton Wellesley Hospital, Newton, MA, USA M. K. Dwyer, J. C. McCarthy, Department of Orthopaedics, Massachusetts General Hospital, Boston, MA, USA A. Boone, Tufts University School of Medicine, Boston, MA, USA.

Background: Few studies have examined long-term outcomes for patients after arthroscopic treatment for intraarticular hip conditions, and none have done so beyond 10 years postarthroscopy. Examining outcomes beyond 10 years is necessary to determine factors that contribute to conversion to THA in patients undergoing hip arthroscopy for labrochondral damage.

Questions/purposes: (1) What is hip survivorship free from THA in patients who underwent arthroscopic labral débridement, with or without chondroplasty at least 15 years before? (2) What factors are associated with conversion to THA after arthroscopic labral débridement, with or without chondroplasty? (3) Can these data be used to estimate the risk of conversion to THA based on patient- and hip-related factors?

Methods: Between 1989 and 2000, one surgeon performed 552 arthroscopic hip procedures for symptomatic labral tears, with or without associated articular cartilage damage. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000717DOI Listing

Complications Following Orthognathic Surgery for Patients With Cleft Lip/Palate.

J Craniofac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan, South Korea.

Introduction: Cleft lip/palate is a facial anomaly caused by an abnormal developmental process. It is also the most common congenital anomaly. Orthognathic surgery is required in 25% of patients with cleft lip and palate for the correction of dentofacial deformity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005536DOI Listing

Management of Pediatric Tibial Shaft Fractures.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the University of Texas Health Science Center at San Antonio, San Anotonio, TX.

Diaphyseal tibia fractures in the pediatric population have dynamic treatment strategies that depend on injury pattern, mechanism, patient skeletal maturity and size. Treatment strategies include closed reduction and cast immobilization, flexible nails, uniplanar or multiplanar external fixation or plate osteosynthesis. Accepted parameters for sagittal and coronal alignment vary based on age and potential for remodeling, although all fractures should have minimal rotational malalignment and less than 1 cm of shortening. Read More

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http://dx.doi.org/10.5435/JAAOS-D-17-00819DOI Listing

A Patient-Specific Single Sensor IoT-Based Wearable Fall Prediction and Detection System.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 16. Epub 2019 Apr 16.

Falls in! older adults are a major cause of morbidity and mortality and are a key class of preventable injuries. This paper presents a patient-specific (PS) fall prediction and detection prototype system that utilizes a single tri-axial accelerometer attached to the patient's thigh to distinguish between activities of daily living (ADL) and fall events. The proposed system consists of two modes of operation: 1) fast mode for fall predication (FMFP) predicting a fall event (300msec-700msec) before occurring, 2) slow mode for fall detection (SMFD) with a 1-sec latency for detecting a fall event. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2911602DOI Listing

Do Outcomes or Subsequent Injuries Differ After Ulnar Collateral Ligament Reconstruction With Palmaris Versus Hamstring Autograft?

Am J Sports Med 2019 Apr 18:363546519836086. Epub 2019 Apr 18.

Rothman Orthopaedic Institute, New York, New York, USA.

Background: Ulnar collateral ligament reconstruction (UCLR) is a successful procedure in professional baseball players. It is unclear whether graft choice affects results.

Purpose: Determine performance and rate of return to sport (RTS) in professional baseball players after UCLR and compare performance and RTS rate, as well as injury rates, between players who underwent UCLR with hamstring versus palmaris autograft. Read More

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http://dx.doi.org/10.1177/0363546519836086DOI Listing
April 2019
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Cognitive workload measurement and modeling under divided attention.

J Exp Psychol Hum Percept Perform 2019 Apr 18. Epub 2019 Apr 18.

Division of Psychology, University of Tasmania.

Motorists often engage in secondary tasks unrelated to driving that increase cognitive workload, resulting in fatal crashes and injuries. An International Standards Organization method for measuring a driver's cognitive workload, the detection response task (DRT), correlates well with driving outcomes, but investigation of its putative theoretical basis in terms of finite attention capacity remains limited. We address this knowledge gap using evidence-accumulation modeling of simple and choice versions of the DRT in a driving scenario. Read More

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http://dx.doi.org/10.1037/xhp0000638DOI Listing

Health Education Training Embedded in a Microfinance Platform Associated with Safer Sexual Behavior in Haitian Women.

AIDS Behav 2019 Apr 17. Epub 2019 Apr 17.

Fonkoze Foundation, Port-au-Prince, Haiti.

Sexual health education interventions have generally yielded modest impact, but may be more successful when integrated into programs designed to alleviate poverty and empower women. Between December 2017 and February 2018, we interviewed 304 Haitian female microfinance clients, 75 of whom had received health education training delivered within their regular meetings. Participants reported six key sexual health outcomes. Read More

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http://dx.doi.org/10.1007/s10461-019-02511-xDOI Listing

Metabolic Labeling of Live Stem Cell for In Vitro Imaging and In Vivo Tracking.

Methods Mol Biol 2019 Apr 18. Epub 2019 Apr 18.

Research Group for Biomimetic Advanced Technology, Korea Institute of Toxicology, Daejeon, Korea.

Stem cell therapy offers promising solutions to diseases and injuries that traditional medicines and therapies can't effectively cure. To get and explain their full therapeutic potentials, the survival, viability, integration, homing, and differentiation of stem cells after transplant must be clearly understood. To meet these urgent needs, noninvasive stem cell imaging and tracking technologies have been developed. Read More

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http://dx.doi.org/10.1007/7651_2019_224DOI Listing

Recovery of shoulder abduction in traumatic brachial plexus palsy: a systematic review and meta-analysis of nerve transfer versus nerve graft.

Neurosurg Rev 2019 Apr 17. Epub 2019 Apr 17.

Emory University School of Medicine, 1365-B Clifton Rd NE, Suite B6200, Atlanta, GA, 30322, USA.

Brachial plexus palsy is a surgically manageable condition. Re-animating the shoulder is a high priority for restoring upper extremity function. Methods for reinnervating injured nerves include the transfer of a healthy nerve or fascicle distal to the site of injury, or grafting a healthy sensory nerve to restore motor function. Read More

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http://link.springer.com/10.1007/s10143-019-01100-9
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http://dx.doi.org/10.1007/s10143-019-01100-9DOI Listing
April 2019
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Development of a quality of life questionnaire for nursing home residents in mainland China.

Qual Life Res 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, Shandong University, No. 44, Wenhua Xi Road, Jinan, 250012, Shandong, China.

Objective: To develop and validate a quality of life (QOL) questionnaire for nursing home (NH) residents in mainland China.

Methods: A cross-sectional study including a development sample (n = 176) and validation sample (n = 371) of NH residents aged 60 and older was conducted between 2015 and 2016 in Jinan, Shandong Province, China. Resident interviews, literature reviews, expert panels, and pilot studies were used to identify QOL domains and items pertinent to NH life. Read More

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http://dx.doi.org/10.1007/s11136-019-02180-2DOI Listing

Randomised study of the effects of fluoride and time on in situ remineralisation of acid-softened enamel.

Clin Oral Investig 2019 Apr 17. Epub 2019 Apr 17.

Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.

Objectives: This single-centre, randomised, crossover study used a short-term in situ dental erosion remineralisation model to explore the remineralisation of acid-softened enamel in the 4-h period immediately following brushing with an anti-erosion, dentin hypersensitivity test dentifrice containing 1150 ppm fluoride (as sodium fluoride [NaF]) or a placebo dentifrice with no fluoride.

Materials And Methods: Fifty participants wearing a palatal appliance holding surface-softened bovine enamel specimens brushed their natural teeth with their assigned dentifrice. Specimens were removed at 5-, 10-, 15-, 30-, 60-, 120- and 240-min post brushing. Read More

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http://link.springer.com/10.1007/s00784-019-02900-5
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http://dx.doi.org/10.1007/s00784-019-02900-5DOI Listing
April 2019
1 Read

Anatomic medial complex reconstruction in serious medial knee instability results in excellent mid-term outcomes.

Knee Surg Sports Traumatol Arthrosc 2019 Apr 17. Epub 2019 Apr 17.

Department of Orthopaedic Surgery, KonKuk University Medical Center, 120-1, Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea.

Purpose: To evaluate the mid-term outcomes of anatomic medial complex reconstruction in cases of serious medial knee instability.

Methods: Between 2010 and 2013, 23 patients who underwent anatomic medial complex reconstruction with a minimum 5-year follow-up were included. The Lysholm score, International Knee Documentation Committee subjective knee form (IKDC SKF), and Tegner activity scale scores were evaluated. Read More

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http://dx.doi.org/10.1007/s00167-019-05367-9DOI Listing

A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.

Am J Clin Nutr 2019 Apr 17. Epub 2019 Apr 17.

Departments of Nutrition Science, Purdue University, West Lafayette, IN.

Background: Low-calorie sweeteners (LCSs) provide sweetness with little or no energy. However, each LCS's unique chemical structure has potential to elicit different sensory, physiological, and behavioral responses that affect body weight.

Objective: The purpose of this trial was to compare the effects of consumption of 4 LCSs and sucrose on body weight, ingestive behaviors, and glucose tolerance over a 12-wk intervention in adults (18-60 y old) with overweight or obesity (body mass index 25-40 kg/m2). Read More

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http://dx.doi.org/10.1093/ajcn/nqy381DOI Listing

Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Hum Mol Genet 2019 Apr 1. Epub 2019 Apr 1.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are two pathologically distinct chronic lung diseases that are associated with cigarette smoking. Genetic studies have identified shared loci for COPD and IPF, including several loci with opposite directions of effect. The existence of additional shared genetic loci, as well as potential shared pathobiological mechanisms between the two diseases at the molecular level, remains to be explored. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz069DOI Listing
April 2019
1 Read

Reducing hospital-acquired pressure injuries.

BMJ Open Qual 2019 13;8(1):e000464. Epub 2019 Feb 13.

General Department of Medical Services, Quality & Patient Safety, Riyadh, Saudi Arabia.

Hospital-acquired pressure injury is a common preventable condition. Our hospital is a 144-bed governmental hospital in the Kingdom of Saudi Arabia that was found to have a 7.5% prevalence of hospital-acquired pressure injury in 2016. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440606PMC
February 2019

Effects of Light Touch on Balance in Patients with Stroke.

Open Med (Wars) 2019 9;14:259-263. Epub 2019 Apr 9.

Department of Physical Therapy, College of Health Science, Gachon University, Incheon, Republic of Korea, 191 Hambangmoe-ro, Yeonsu-gu, Inchon, 406-799, Republic of Korea.

Light touch is the combination of cutaneous and kinesthetic inputs. The literature suggests that light touch compensates for a reduced amount of center of pressure information in older peoples, blind subjects and patients with neurological disorder. This study investigated the effects of light touch applied to an external bar, on the postural sway in individuals with hemiparetic stroke. Read More

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http://dx.doi.org/10.1515/med-2019-0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463820PMC

Clinical Conundrums in the Management of Diabetic Ketoacidosis in the Elderly.

J Transl Int Med 2019 Mar 29;7(1):10-14. Epub 2019 Mar 29.

St. Vincent Hospital Indianapolis, IN, Indianapolis, USA.

One of the dreaded life-threatening complications of diabetes mellitus (DM) is diabetic ketoacidosis (DKA). American Diabetic Association (ADA) came out with 2018 guidelines on the management of DM and its complications, but these are woefully silent on the clinical conundrums that accompany DKA in elderly patients. In elderly patients, DKA is often complicated by sepsis, atrial fibrillation, polypharmacy, nonketotic hyperosmolar states, atypical clinical presentations, acute kidney injury (AKI), dementia, and noncompliance with medications. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p1
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http://dx.doi.org/10.2478/jtim-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463825PMC
March 2019
1 Read

INJURY INCIDENCE IN COMPETITIVE CROSS-COUNTRY SKIERS: A PROSPECTIVE COHORT STUDY.

Int J Sports Phys Ther 2019 Apr;14(2):237-252

Professor Emerita, Department of Rehabilitation Sciences, University of Vermont, Burlington, VT, USA.

Background/purpose: Endurance sports, including cross-country skiing, require long hours of repetitive training potentially increasing the chance of injury, yet injury incidence and risk factors for adult cross-country skiers remain relatively unexplored. Data for elite adult north American competitive cross-country skiers is unexplored. A 12 month prospective surveillance study was undertaken to calculate the injury incidence and exposure of cross-country skiers. Read More

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EFFICACY OF PERTURBATION-ENHANCED NEUROMUSCULAR TRAINING ON HAMSTRING AND QUADRICEPS ONSET TIME, ACTIVATION AND KNEE FLEXION DURING A TUCK-JUMP TASK.

Int J Sports Phys Ther 2019 Apr;14(2):214-227

Department of Physical Education and Sports Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran.

Background: Deficits in dynamic neuromuscular control of the knee may contribute to the higher incidence of the anterior cruciate ligament (ACL), specifically in female athletes. Little is known about the effects of preventive training programs on muscle onset time and activation during functional tasks.

Purpose: The purpose of this study was to evaluate the efficacy of perturbation-enhanced neuromuscular training on hamstring and quadriceps onset time and activation, and knee flexion angle in female athletes with quadriceps dominance (QD) deficit during a tuck-jump (TJ) task. Read More

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THE MODIFIED STAR EXCURSION BALANCE AND Y-BALANCE TEST RESULTS DIFFER WHEN ASSESSING PHYSICALLY ACTIVE HEALTHY ADOLESCENT FEMALES.

Int J Sports Phys Ther 2019 Apr;14(2):192-203

Background: The modified Star Excursion Balance Test (mSEBT) and Y-Balance Test (YBT) are two common methods for clinical assessment of dynamic balance. Clinicians often use only one of these test methods and one outcome factor when screening for lower extremity injury risk. Dynamic balance scores are known to vary by age, sex and sport. Read More

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DEFINING LOWER EXTREMITY DOMINANCE: THE RELATIONSHIP BETWEEN PREFERRED LOWER EXTREMITY AND TWO FUNCTIONAL TASKS.

Int J Sports Phys Ther 2019 Apr;14(2):188-191

Pivot Physical Therapy in Mechanicsburg, PA, USA.

Background: A commonly utilized operational definition of lower extremity (LE) dominance assumes the LE with which a participant prefers to kick a ball with is the same preferred LE a participant would choose for a unilateral landing task.

Hypothesis/purpose: The purpose of this study was to determine the relationship between the preferred lower extremity (LE) when performing a unilateral landing and kicking task. The authors hypothesized a strong correlation between the LE the participant chose for the landing task and the LE the participant chose for the kicking task would be evident. Read More

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USE OF 2-DIMENSIONAL SAGITTAL KINEMATIC VARIABLES TO ESTIMATE GROUND REACTION FORCE DURING RUNNING.

Int J Sports Phys Ther 2019 Apr;14(2):174-179

Rueckert-Hartman College of Health Professions, School of Physical Therapy, Regis University, Denver, CO.

Background: Variations in vertical loading rates have been associated with overuse injuries of the lower extremity; however, they are typically collected using 3-dimensional motion capture systems and in-ground force plates not available to most clinicians because of cost and space constraints.

Purpose: The purpose of this study was to determine if kinetic measures commonly used to describe lower extremity loading characteristics could be estimated from step rate and specific sagittal plane kinematic variables captured using 2-dimensional motion analysis during treadmill running.

Study Design: Observational Study. Read More

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Systematic review of evidence on public health in the Democratic People's Republic of Korea.

BMJ Glob Health 2019 9;4(2):e001133. Epub 2019 Mar 9.

Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Background: Engaging in public health activities in the Democratic People's Republic of Korea (DPRK, also known as North Korea) offers a means to improve population health for its citizens and the wider region. Such an engagement requires an understanding of current and future needs.

Methods: We conducted a systematic search of five English and eight Korean language databases to identify available literature published between 1988 and 2017. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441257PMC

Global, regional and national burden of emergency medical diseases using specific emergency disease indicators: analysis of the 2015 Global Burden of Disease Study.

BMJ Glob Health 2019 30;4(2):e000733. Epub 2019 Mar 30.

The Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: There are currently no metrics for measuring population-level burden of emergency medical diseases (EMDs). This study presents an analysis of the burden of EMDs using two metrics: the emergency disease mortality rate (EDMR) and the emergency disease burden (EDB) per 1000 population at the national, regional and global levels.

Methods: We used the 1990 and 2015 Global Burden of Disease Study for morbidity and mortality data on 249 medical conditions in 195 countries. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-000733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441258PMC

Pacing therapy in the management of unexplained syncope: a tertiary care centre prospective study.

Open Heart 2019 25;6(1):e001015. Epub 2019 Mar 25.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.

Methods: Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2019-001
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http://dx.doi.org/10.1136/openhrt-2019-001015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443123PMC
March 2019
1 Read

Are optical trocars free of complications?

Clin Case Rep 2019 Apr 9;7(4):851. Epub 2019 Mar 9.

Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery University of Illinois at Chicago Chicago Illinois.

Optical view trocars provide an acceptable level of safety for port entry during minimally invasive surgery. Nevertheless, this technique is not exempt from potential complications. These can range from a minor subcutaneous insufflation that will not require any further treatment to abdominal aorta injuries. Read More

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http://dx.doi.org/10.1002/ccr3.2091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452478PMC

ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.

Clin Case Rep 2019 Apr 17;7(4):619-625. Epub 2019 Feb 17.

OTR3 (Organe, Tissue, Régénération, Réparation, Remplacement) Paris France.

CACIPLIQ20 significantly improved the outcomes of severe burn injuries of the hand. Healing was accelerated, with little or no scarring, allowing for greater mobility over the joints and maintained suppleness. Functional recovery was achieved in all cases. Read More

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http://dx.doi.org/10.1002/ccr3.2054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452499PMC

Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.

Chem Sci 2019 Mar 28;10(11):3271-3280. Epub 2019 Jan 28.

MOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email:

Targeted antibody blocking enables characterization of binding sites on immunoglobulin G (IgG), and can efficiently eliminate harmful antibodies from organisms. In this report, we present a novel peptide-denoted as a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF)-for targeted blocking of antibodies. Synthesis of DCAF was achieved by native chemical ligation, and the molecule consists of three functional parts: a specific antigenic peptide, a linker and the Fc-III mimetic peptide, which has a high affinity toward the Fc region of IgG molecules. Read More

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http://xlink.rsc.org/?DOI=C8SC05273E
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http://dx.doi.org/10.1039/c8sc05273eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429600PMC
March 2019
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Analysis of pre-residency research productivity, dual degree status, and gender distribution of underrepresented minorities among a current United States radiation oncology junior resident class.

Rep Pract Oncol Radiother 2019 May-Jun;24(3):284-287. Epub 2019 Apr 5.

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.

Background: Among the most competitive medical subspecialties, representation of underrepresented minorities (African-American race and/or Hispanic ethnicity) among resident trainees has historically been low compared to their United States Census general population representation. Research productivity and dual degree status may impact residency applicant competitiveness. To date, such an analysis has yet to be performed in Radiation Oncology. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451161PMC

Nerve Injury After Surgical Excision of Mandibular Third Molars Under Local Anesthesia: An Audit.

J Maxillofac Oral Surg 2019 Jun 19;18(2):307-313. Epub 2018 Sep 19.

4Duke-NUS Singapore, Singapore, Singapore.

Background: Injury of the inferior alveolar nerve (IAN) sustained during surgical removal of an impacted lower third molar may cause paresthesia of the lower lip, chin, lower gingivae and anterior teeth. Lingual nerve (LN) injuries may result in ipsilateral paresthesia of the anterior two thirds of the tongue, mucosa of floor of mouth and lingual gingivae. A close anatomic relationship between the roots of the third molar and mandibular canal places the IAN at risk of damage. Read More

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http://dx.doi.org/10.1007/s12663-018-1151-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441419PMC

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Sci Rep 2019 Apr 17;9(1):6210. Epub 2019 Apr 17.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b and Scn1a mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA-evoked currents compared to wildtype in the third postnatal week. Read More

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http://dx.doi.org/10.1038/s41598-019-42191-0DOI Listing

Injury registration for primary prevention in a provincial Russian region: setting up a new trauma registry.

Scand J Trauma Resusc Emerg Med 2019 Apr 17;27(1):47. Epub 2019 Apr 17.

Department of Community Medicine, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway.

Background: The Shenkursk Injury Registry (SHIR) was established in the Shenkursk District, Northwestern Russia in 2015 for the purposes of primary prevention. The SHIR covers all injuries (ICD-10 diagnoses from S00 to T78) for which medical aid is given at the Shenkursk central district hospital and includes data about injury circumstances. We used the SHIR data to assess the quality of the SHIR as an evidence basis and for the local preventive applications. Read More

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http://dx.doi.org/10.1186/s13049-019-0627-1DOI Listing

Caustic Agents Ingestion in Children: A 51-Year Retrospective Cohort Study.

Ear Nose Throat J 2019 Apr 17:145561319843109. Epub 2019 Apr 17.

3 Clinic of Pediatric Otolaryngology, Phoniatrics and Audiology, Medical University of Lublin, Lublin, Poland.

Objectives: Children experience serious gastrointestinal tract injuries due to consumption of caustic agents more often than adults. The aim of the study was to analyze diagnostic methods and treatment of children with esophageal burns according to the degree of the injury.

Methods: Our one-center population-based retrospective cohort study included 150 children admitted between 1967 and 2018 to Clinic of Pediatric Otolaryngology, Phoniatrics and Audiology of University Children's Hospital in Lublin, Poland, due to the chemical burn of the mouth, throat, larynx, and esophagus. Read More

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http://dx.doi.org/10.1177/0145561319843109DOI Listing

Melittin Exerts Beneficial Effects on Paraquat-Induced Lung Injuries In Mice by Modifying Oxidative Stress and Apoptosis.

Molecules 2019 Apr 16;24(8). Epub 2019 Apr 16.

Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom 32512, Egypt.

Melittin (MEL) is a 26-amino acid peptide with numerous biological activities. Paraquat (PQ) is one of the most widely used herbicides, although it is extremely toxic to humans. To date, PQ poisoning has no effective treatment, and therefore the current study aimed to assess for the first time the possible effects of MEL on PQ-induced lung injuries in mice. Read More

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http://dx.doi.org/10.3390/molecules24081498DOI Listing

Effects of Intraoperative Nefopam on Catheter-Related Bladder Discomfort in Patients Undergoing Robotic Nephrectomy: A Randomized Double-Blind Study.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Gyeonggi-do 15355, Korea.

Catheter-related bladder discomfort (CRBD) is one of the most difficult symptoms during the postoperative period. Nefopam is a non-narcotic analgesic agent, which also has anticholinergic action. This study was performed to evaluate the effects of nefopam on CRBD in male patients undergoing robotic nephrectomy. Read More

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http://dx.doi.org/10.3390/jcm8040519DOI Listing

Laparoscopy First Approach in Acute Care Surgery.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Introduction: The use of laparoscopic management as a first choice for the treatment of duodenal perforation is gaining ground but is not routine in many centers. In this report we aim to report our experience with laparoscopy as the first approach for the repair of duodenal perforation.

Materials And Methods: This is a retrospective review of patients during our initial experience with the use of laparoscopy for the treatment of duodenal perforation between 2009 and 2013. Read More

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http://dx.doi.org/10.1159/000500107DOI Listing
April 2019
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Motorcycle helmet visor-related facial injury and its potential mechanism of injury: Evidence-based case study.

Traffic Inj Prev 2019 Apr 17:1-4. Epub 2019 Apr 17.

b Monash University Accident Research Centre (MUARC), Monash University , Victoria , Australia.

Objectives: We encountered an unusual facial laceration wound in relation to motorcycle helmet visor use during our clinical practice. We aimed to assess the prevalence of this unusual facial injury among motorcyclists who sustained facial injuries in selected hospitals and to determine the possible mechanism involved.

Methods: We used our prospective cross-sectional substudy involving injured motorcyclists presenting at major trauma hospitals in Southern Klang Valley, Malaysia, between March 2010 and March 2011. Read More

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http://dx.doi.org/10.1080/15389588.2018.1557640DOI Listing

A Warm-Up Program to Reduce Injuries in Youth Field Hockey Players: A Quasi-Experiment.

J Athl Train 2019 Apr 17. Epub 2019 Apr 17.

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, VU University Medical Center, the Netherlands.

Context: Field hockey is popular worldwide; however, it entails a risk of injury. Injuries hamper players' participation in the sport and impose a burden on public health.

Objective: To investigate the effectiveness of a structured exercise program among youth field hockey players on the injury rate, severity, and burden. Read More

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http://natajournals.org/doi/10.4085/1062-6050-79-18
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http://dx.doi.org/10.4085/1062-6050-79-18DOI Listing
April 2019
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